Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC46A2 Gene

Aliases for SLC46A2 Gene

  • Solute Carrier Family 46, Member 2 2 3
  • TSCOT 3 4 6
  • Thymic Stromal Co-Transporter 2 3
  • Thymic Stromal Cotransporter Homolog 3
  • Solute Carrier Family 46 Member 2 4
  • Ly110 3

External Ids for SLC46A2 Gene

Previous Symbols for SLC46A2 Gene

  • TSCOT

Summaries for SLC46A2 Gene

GeneCards Summary for SLC46A2 Gene

SLC46A2 (Solute Carrier Family 46, Member 2) is a Protein Coding gene. GO annotations related to this gene include symporter activity. An important paralog of this gene is SLC46A3.

UniProtKB/Swiss-Prot for SLC46A2 Gene

  • May act as a transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC46A2 Gene

Genomics for SLC46A2 Gene

Genomic Location for SLC46A2 Gene

Start:
112,878,920 bp from pter
End:
112,890,913 bp from pter
Size:
11,994 bases
Orientation:
Minus strand

Genomic View for SLC46A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC46A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC46A2 Gene

Regulatory Elements for SLC46A2 Gene

Proteins for SLC46A2 Gene

  • Protein details for SLC46A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY10-TSCOT_HUMAN
    Recommended name:
    Thymic stromal cotransporter homolog
    Protein Accession:
    Q9BY10
    Secondary Accessions:
    • B1ALK1
    • Q86VT0
    • Q96NE2

    Protein attributes for SLC46A2 Gene

    Size:
    475 amino acids
    Molecular mass:
    51067 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC46A2 Gene

Proteomics data for SLC46A2 Gene at MOPED

Post-translational modifications for SLC46A2 Gene

Other Protein References for SLC46A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC46A2 Gene

Domains for SLC46A2 Gene

Gene Families for SLC46A2 Gene

Protein Domains for SLC46A2 Gene

UniProtKB/Swiss-Prot:

TSCOT_HUMAN
Family:
  • Belongs to the major facilitator superfamily. SLC46A family.:
    • Q9BY10
genes like me logo Genes that share domains with SLC46A2: view

Function for SLC46A2 Gene

Molecular function for SLC46A2 Gene

UniProtKB/Swiss-Prot Function: May act as a transporter.

Gene Ontology (GO) - Molecular Function for SLC46A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015293 symporter activity NAS 10978518
genes like me logo Genes that share ontologies with SLC46A2: view

Phenotypes for SLC46A2 Gene

genes like me logo Genes that share phenotypes with SLC46A2: view

miRNA for SLC46A2 Gene

miRTarBase miRNAs that target SLC46A2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC46A2 Gene

Localization for SLC46A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC46A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC46A2 Gene COMPARTMENTS Subcellular localization image for SLC46A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC46A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane NAS 10978518
genes like me logo Genes that share ontologies with SLC46A2: view

Pathways for SLC46A2 Gene

SuperPathways for SLC46A2 Gene

No Data Available

Interacting Proteins for SLC46A2 Gene

Gene Ontology (GO) - Biological Process for SLC46A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043029 T cell homeostasis IEA --
GO:0045580 regulation of T cell differentiation IEA --
GO:0048538 thymus development IEA --
GO:0055085 transmembrane transport IEA --
GO:0070233 negative regulation of T cell apoptotic process IEA --
genes like me logo Genes that share ontologies with SLC46A2: view

No data available for Pathways by source for SLC46A2 Gene

Transcripts for SLC46A2 Gene

mRNA/cDNA for SLC46A2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC46A2 Gene

Solute carrier family 46, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC46A2 Gene

No ASD Table

Relevant External Links for SLC46A2 Gene

GeneLoc Exon Structure for
SLC46A2
ECgene alternative splicing isoforms for
SLC46A2

Expression for SLC46A2 Gene

mRNA expression in normal human tissues for SLC46A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC46A2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (16.7), Skin - Not Sun Exposed (Suprapubic) (12.3), Whole Blood (6.2), Lung (4.4), and Bladder (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC46A2 Gene

SOURCE GeneReport for Unigene cluster for SLC46A2 Gene Hs.512668

mRNA Expression by UniProt/SwissProt for SLC46A2 Gene

Q9BY10-TSCOT_HUMAN
Tissue specificity: Strongly expressed in the adult thymus. Expressed in spleen, lymph nodes, thymus, PBL, bone marrow and fetal liver.
genes like me logo Genes that share expressions with SLC46A2: view

Orthologs for SLC46A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC46A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC46A2 36
  • 99.51 (n)
  • 99.79 (a)
SLC46A2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC46A2 36
  • 85.55 (n)
  • 82.4 (a)
TSCOT 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC46A2 36
  • 85.55 (n)
  • 83.72 (a)
SLC46A2 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc46a2 36
  • 80.69 (n)
  • 78.01 (a)
Slc46a2 16
Slc46a2 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC46A2 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC46A2 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc46a2 36
  • 80.1 (n)
  • 76.37 (a)
chicken
(Gallus gallus)
Aves SLC46A2 36
  • 63.55 (n)
  • 60.75 (a)
SLC46A2 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC46A2 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487203 36
  • 54.91 (n)
  • 50.81 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100002406 36
  • 55.13 (n)
  • 47.36 (a)
SLC46A2 37
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15553 37
  • 15 (a)
ManyToMany
CG15890 37
  • 14 (a)
ManyToMany
CG30344 37
  • 17 (a)
ManyToMany
CG30345 37
  • 16 (a)
ManyToMany
CG31321 37
  • 13 (a)
ManyToMany
CG42514 37
  • 17 (a)
ManyToMany
CG8008 37
  • 15 (a)
ManyToMany
CG8046 37
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y43F8A.5 37
  • 14 (a)
ManyToMany
Y4C6B.5 37
  • 21 (a)
ManyToMany
Species with no ortholog for SLC46A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC46A2 Gene

ENSEMBL:
Gene Tree for SLC46A2 (if available)
TreeFam:
Gene Tree for SLC46A2 (if available)

Paralogs for SLC46A2 Gene

Paralogs for SLC46A2 Gene

genes like me logo Genes that share paralogs with SLC46A2: view

Variants for SLC46A2 Gene

Sequence variations from dbSNP and Humsavar for SLC46A2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2236600 -- 112,879,483(+) AGCCT(C/G)CCTGT utr-variant-3-prime
rs3802490 -- 112,890,647(-) GGGCC(A/C)CCTGC reference, missense
rs3802491 -- 112,890,601(-) GTGGC(A/C)TCGTC synonymous-codon, reference
rs3802492 -- 112,890,556(-) CTCCT(C/T)GTGGT reference, synonymous-codon
rs3802493 -- 112,887,240(-) CACTT(A/G)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC46A2 Gene

Variant ID Type Subtype PubMed ID
dgv2411e1 CNV Complex 17122850
dgv2412e1 CNV Complex 17122850
nsv893733 CNV Gain 21882294
esv2422302 CNV Deletion 17116639
dgv2414e1 CNV Complex 17122850
nsv529036 CNV Loss 19592680

Relevant External Links for SLC46A2 Gene

HapMap Linkage Disequilibrium report
SLC46A2

Disorders for SLC46A2 Gene

Relevant External Links for SLC46A2

Genetic Association Database (GAD)
SLC46A2
genes like me logo Genes that share disorders with SLC46A2: view

No data available for UniProtKB/Swiss-Prot for SLC46A2 Gene

Publications for SLC46A2 Gene

  1. Characterization of the mouse gene, human promoter and human cDNA of TSCOT reveals strong interspecies homology. (PMID: 10978518) Chen C. … Flomerfelt F.A. (Biochim. Biophys. Acta 2000) 2 3 4 23
  2. A putative 12-transmembrane domain cotransporter associated with apical membranes of the epididymal duct. (PMID: 12826694) Obermann H. … Kirchhoff C. (J. Androl. 2003) 2 3 23
  3. Polymorphisms in 9q32 and TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis. (PMID: 18392855) Engelmark M.T. … Gyllensten U.B. (Hum. Genet. 2008) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SLC46A2 Gene

  • antibodies-online proteins for SLC46A2
  • antibodies-online antibodies for SLC46A2
  • antibodies-online kits for SLC46A2

Sources for SLC46A2 Gene

Back to Top

Content