SLC45A4 Gene
protein-coding GIFtS : 39
GCID: GC08 M142218
solute carrier family 45, member 4
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Aliasesfor SLC45A4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Solute Carrier Family 45, Member 4 1 2 KIAA11261 3 Solute Carrier Family 45 Member 42
Export aliases for SLC45A4 gene to outside databases Previous GC identifers: GC08M142287 GC08M137532
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Summariesfor SLC45A4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor SLC45A4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000008.10 NC_018919.1 NT_008046.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SLC45A4 gene promoter: Max1 Egr-1 SREBP-1c RREB-1 HNF-4alpha1 SREBP-1b SREBP-1a Nkx6-1 Zic3 c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for SLC45A4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC45A4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3 SLC45A4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08M142218: view genomic region
(about GC identifiers )
Start:
142,217,265 bp from pter
End:
142,318,404 bp from pter
Size:
101,140 bases
Orientation:
minus strand
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Proteinsfor SLC45A4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: S45A4_HUMAN, Q5BKX6 (See
protein sequence )Recommended Name: Solute carrier family 45 member 4 Size : 768 amino acids; 83878 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Sequence caution : Sequence=AAH90891.1; Type=Erroneous initiation;
Secondary accessions : Q6ZRI2 Q9ULU3Alternative splicing : 3 isoforms : Q5BKX6-1 Q5BKX6-2 Q5BKX6-3 (No experimental confirmation available. Ref.1 (BAC87328) sequence is in conflict in position: 787:E->K)Explore the universe of human proteins at neXtProt for SLC45A4: NX_Q5BKX6 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5BKX6 SLC45A4 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_001073900.1 ENSEMBL proteins: ENSP00000429059 ENSP00000428137 ENSP00000024061 ENSP00000429033 ENSP00000429974 ENSP00000400799 Human Recombinant Protein Products for SLC45A4: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
SLC45A4 for ontologies About GeneDecksing SLC45A4 Antibody Products: Assay Products for SLC45A4:
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Protein
Domains / Familiesfor SLC45A4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SLC45A4 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q5BKX6 ProtoNet protein and cluster: Q5BKX6
UniProtKB/Swiss-Prot: S45A4_HUMAN, Q5BKX6 Similarity : Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family
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Functionfor SLC45A4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC45A4 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC45A4 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SLC45A4 (NM_001080431 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC45A4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC45A4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A4
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Pathways & Interactionsfor SLC45A4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC45A4 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for SLC45A4 (ENSP00000024061 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006810 transport
IEA --
SLC45A4 for ontologies About GeneDecksing
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Drugs & Compoundsfor SLC45A4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SLC45A4 Search CenterWatch for drugs/clinical trials and news about SLC45A4 / S45A4
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Transcriptsfor SLC45A4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SLC45A4 gene: NM_001080431.1 Unigene Cluster for SLC45A4:
Solute carrier family 45, member 4 Hs.372492 [show with all ESTs ] Unigene Representative Sequence: AB032952 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000519067 (uc003ywc.1 ) ENST00000517878 ENST00000024061 (uc003ywd.1 )ENST00000520137 ENST00000519986 ENST00000521804 ENST00000433583 (uc010meq.1 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC45A4 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC45A4 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SLC45A4 (NM_001080431 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC45A4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC45A4
Additional cDNA sequence: AB032952.1 AK128212.1 AL137490.1 AL713711.1 BC007262.1 BC033223.1 BC090891.1 BC157840.1 BC171836.1
4 DOTS entries : DT.110688 DT.121480243
DT.97775638 DT.95150713 24/124 AceView cDNA sequences (see all 124 ):
AL137490 AW449659 BQ637812 BC007262 AL713711 BU845873 BU557336 BU556545 AI472138 BU540798 AI469356 CB270759 BC033223 AA757302 BX281730 BF510325 AK128212 C01438 CN479264 BF094072 AI339074 AB032952 AI346128 BF970110 GeneLoc Exon Structure
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Expression for SLC45A4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SLC45A4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: -- About this image See SLC45A4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SLC45A4 SOURCE GeneReport for Unigene cluster: Hs.372492 SABiosciences Custom PCR Arrays for SLC45A4
Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SLC45A4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SLC45A4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SLC45A4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SLC45A4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A4
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Orthologsfor SLC45A4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC45A4 gene from 6/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for SLC45A4 (if available)TreeFam Gene Tree for SLC45A4 (if available)
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Paralogsfor SLC45A4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SLC45A4 gene SLC45A1 2 SLC45A3 2 SLC45A2 2 2 SIMAP similar genes for SLC45A4 using alignment to 7 protein entries: S45A4_HUMAN (see all proteins ):SLC45A2 SLC45A1
SLC45A4 for paralogs About GeneDecksing
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Genomic Variantsfor SLC45A4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 8 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SLC45A4 (142217265 - 142318404 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for SLC45A4 2 CNVs : 30287 30286
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SLC45A4
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Disorders
/ Diseasesfor SLC45A4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor SLC45A4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SLC45A4 gene integrated from 9 sources : (articles sorted by number of sources associating them with SLC45A4) Utopia : connect your pdf to the dynamic world of online information
Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461) 1 , 2 Hirosawa M.... Ohara O. (1999) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) DNA sequence and analysis of human chromosome 8. (PubMed id 16421571) 2 Nusbaum C....Lander E.S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SLC45A4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SLC45A4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SLC45A4 gene
(According to HUGE )
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Specialized Databases showing SLC45A4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SLC45A4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SLC45A4 gene: Search GeneIP for patents involving SLC45A4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SLC45A4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SLC45A4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SLC45A4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SLC45A4 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SLC45A4 OriGene 3'-UTR Clone for SLC45A4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC45A4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC45A4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SLC45A4 OriGene Custom Protein Services for SLC45A4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC45A4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SLC45A4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC45A4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SLC45A4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SLC45A4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SLC45A4
Search Tocris compounds for SLC45A4
SLC45A4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A4
Search ThermoFisher Antibodies for SLC45A4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC45A4
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Aliases for SLC45A4
Databases for SLC45A4
Disorders / Diseases for SLC45A4
Domains / Families for SLC45A4
Drugs / Compounds for SLC45A4
Expression for SLC45A4
Function for SLC45A4
Genomic Views for SLC45A4
Intellectual Property for SLC45A4
Orthologs for SLC45A4
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Pathways / Interactions for SLC45A4
Products for SLC45A4
Proteins for SLC45A4
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Transcripts for SLC45A4
Variants for SLC45A4
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