Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC45A4 Gene

Aliases for SLC45A4 Gene

  • Solute Carrier Family 45, Member 4 2 3
  • KIAA1126 4

External Ids for SLC45A4 Gene

Previous GeneCards Identifiers for SLC45A4 Gene

  • GC08M142287
  • GC08M137532
  • GC08M142218

Summaries for SLC45A4 Gene

GeneCards Summary for SLC45A4 Gene

SLC45A4 (Solute Carrier Family 45, Member 4) is a Protein Coding gene. An important paralog of this gene is SLC45A3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC45A4 Gene

Genomics for SLC45A4 Gene

Regulatory Elements for SLC45A4 Gene

Genomic Location for SLC45A4 Gene

141,207,166 bp from pter
141,308,305 bp from pter
101,140 bases
Minus strand

Genomic View for SLC45A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC45A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC45A4 Gene

Proteins for SLC45A4 Gene

  • Protein details for SLC45A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 45 member 4
    Protein Accession:
    Secondary Accessions:
    • Q6ZRI2
    • Q9ULU3

    Protein attributes for SLC45A4 Gene

    768 amino acids
    Molecular mass:
    83878 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH90891.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC45A4 Gene


neXtProt entry for SLC45A4 Gene

Proteomics data for SLC45A4 Gene at MOPED

Post-translational modifications for SLC45A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC45A4 Gene

No data available for DME Specific Peptides for SLC45A4 Gene

Domains for SLC45A4 Gene

Gene Families for SLC45A4 Gene

Protein Domains for SLC45A4 Gene


Suggested Antigen Peptide Sequences for SLC45A4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
  • Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
genes like me logo Genes that share domains with SLC45A4: view

Function for SLC45A4 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC45A4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC45A4 Gene

Localization for SLC45A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC45A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC45A4 Gene COMPARTMENTS Subcellular localization image for SLC45A4 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC45A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC45A4: view

Pathways for SLC45A4 Gene

SuperPathways for SLC45A4 Gene

No Data Available

Interacting Proteins for SLC45A4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000024061 for SLC45A4 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC45A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SLC45A4: view

No data available for Pathways by source for SLC45A4 Gene

Transcripts for SLC45A4 Gene

Unigene Clusters for SLC45A4 Gene

Solute carrier family 45, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC45A4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC45A4 Gene

No ASD Table

Relevant External Links for SLC45A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC45A4 Gene

mRNA expression in normal human tissues for SLC45A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC45A4 Gene

This gene is overexpressed in Whole Blood (7.9).

Protein differential expression in normal tissues for SLC45A4 Gene

This gene is overexpressed in Pancreatic juice (52.0) and Placenta (17.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC45A4 Gene

SOURCE GeneReport for Unigene cluster for SLC45A4 Gene Hs.372492

genes like me logo Genes that share expressions with SLC45A4: view

Expression partners for SLC45A4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC45A4 Gene

Orthologs for SLC45A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC45A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC45A4 35
  • 84.09 (n)
  • 84.38 (a)
SLC45A4 36
  • 75 (a)
(Canis familiaris)
Mammalia SLC45A4 35
  • 87.81 (n)
  • 89.61 (a)
SLC45A4 36
  • 80 (a)
(Mus musculus)
Mammalia Slc45a4 35
  • 84.62 (n)
  • 86.41 (a)
Slc45a4 16
Slc45a4 36
  • 77 (a)
(Pan troglodytes)
Mammalia SLC45A4 35
  • 98.86 (n)
  • 99.21 (a)
SLC45A4 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Slc45a4 35
  • 84.49 (n)
  • 85.88 (a)
(Monodelphis domestica)
Mammalia SLC45A4 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia SLC45A4 36
  • 79 (a)
(Gallus gallus)
Aves SLC45A4 35
  • 74.4 (n)
  • 80.45 (a)
SLC45A4 36
  • 72 (a)
(Anolis carolinensis)
Reptilia SLC45A4 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc45a4 35
  • 73.67 (n)
  • 79.52 (a)
(Danio rerio)
Actinopterygii slc45a4 35
  • 62.27 (n)
  • 61.5 (a)
slc45a4 36
  • 52 (a)
SLC45A4 (1 of 2) 36
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010854 35
  • 49.4 (n)
  • 38.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta Slc45-1 35
  • 50 (n)
  • 37.62 (a)
CG41087 36
  • 33 (a)
Species with no ortholog for SLC45A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC45A4 Gene

Gene Tree for SLC45A4 (if available)
Gene Tree for SLC45A4 (if available)

Paralogs for SLC45A4 Gene

Paralogs for SLC45A4 Gene

(2) SIMAP similar genes for SLC45A4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC45A4: view

Variants for SLC45A4 Gene

Sequence variations from dbSNP and Humsavar for SLC45A4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2474 -- 141,207,296(+) GGGCG(C/T)GGACA utr-variant-3-prime
rs13724 -- 141,210,933(-) TCAAC(A/G)AATAA utr-variant-3-prime
rs753778 - 141,218,810(-) CGAGC(C/T)GCACG reference, missense
rs753779 -- 141,218,710(-) TCGGC(A/G)TTGCA reference, synonymous-codon
rs892361 -- 141,258,033(+) TGTTG(C/T)ACATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC45A4 Gene

Variant ID Type Subtype PubMed ID
esv2737756 CNV Deletion 23290073
nsv831483 CNV Gain 17160897
dgv7890n71 CNV Loss 21882294
nsv891540 CNV Loss 21882294
nsv470239 CNV Loss 18288195
dgv7891n71 CNV Loss 21882294
dgv7892n71 CNV Loss 21882294
nsv516666 CNV Loss 19592680
nsv891549 CNV Loss 21882294
nsv6428 CNV Insertion 18451855
dgv7893n71 CNV Loss 21882294
nsv465955 CNV Loss 19166990

Relevant External Links for SLC45A4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC45A4 Gene

Disorders for SLC45A4 Gene

Relevant External Links for SLC45A4

Genetic Association Database (GAD)

No disorders were found for SLC45A4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SLC45A4 Gene

Publications for SLC45A4 Gene

  1. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3 48
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 48

Products for SLC45A4 Gene

Sources for SLC45A4 Gene

Back to Top