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Aliases for SLC45A4 Gene

Aliases for SLC45A4 Gene

  • Solute Carrier Family 45 Member 4 2 3 5
  • Solute Carrier Family 45, Member 4 2
  • KIAA1126 4

External Ids for SLC45A4 Gene

Previous GeneCards Identifiers for SLC45A4 Gene

  • GC08M142287
  • GC08M137532
  • GC08M142218

Summaries for SLC45A4 Gene

GeneCards Summary for SLC45A4 Gene

SLC45A4 (Solute Carrier Family 45 Member 4) is a Protein Coding gene. An important paralog of this gene is SLC45A1.

Additional gene information for SLC45A4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC45A4 Gene

Genomics for SLC45A4 Gene

GeneHancer (GH) Regulatory Elements for SLC45A4 Gene

Promoters and enhancers for SLC45A4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I141225 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 606.6 +80.8 80819 3.4 PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 SLC45A4 ENSG00000280035 DENND3 ENSG00000253307 LOC105375787 LINC01300 GPR20 PTP4A3
GH08I141307 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 550.8 -0.1 -64 1.7 HDAC1 ATF1 RB1 ZNF76 SIN3A ZBTB40 ZBTB7B ZNF335 GLIS2 SCRT2 SLC45A4 LINC01300 ENSG00000254291
GH08I141310 Enhancer 0.9 ENCODE dbSUPER 550.8 +1.0 953 0.2 HDAC1 CTCF ZNF76 ZBTB7B ZNF335 GLIS2 POLR2A ZBTB48 ZNF600 EGR2 SLC45A4 ENSG00000254197
GH08I141308 Enhancer 0.8 ENCODE dbSUPER 550.8 +1.2 1183 0.2 HDAC1 SP3 SP2 ZNF335 GLIS2 NFIC SMARCA4 POLR2A IKZF1 ZNF600 SLC45A4 ENSG00000254197
GH08I141309 Enhancer 0.5 ENCODE 550.8 -1.0 -1038 0.1 CBX5 SCRT2 ZFP36 ZNF7 TRIM28 SETDB1 SLC45A4 ENSG00000254291
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC45A4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC45A4 gene promoter:

Genomic Locations for SLC45A4 Gene

Genomic Locations for SLC45A4 Gene
101,145 bases
Minus strand

Genomic View for SLC45A4 Gene

Genes around SLC45A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC45A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC45A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC45A4 Gene

Proteins for SLC45A4 Gene

  • Protein details for SLC45A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 45 member 4
    Protein Accession:
    Secondary Accessions:
    • Q6ZRI2
    • Q9ULU3

    Protein attributes for SLC45A4 Gene

    768 amino acids
    Molecular mass:
    83878 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH90891.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC45A4 Gene


neXtProt entry for SLC45A4 Gene

Post-translational modifications for SLC45A4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC45A4 Gene

Domains & Families for SLC45A4 Gene

Gene Families for SLC45A4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC45A4 Gene


Suggested Antigen Peptide Sequences for SLC45A4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
  • Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
genes like me logo Genes that share domains with SLC45A4: view

Function for SLC45A4 Gene

Phenotypes From GWAS Catalog for SLC45A4 Gene

Gene Ontology (GO) - Molecular Function for SLC45A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008506 sucrose:proton symporter activity ISS --
genes like me logo Genes that share ontologies with SLC45A4: view

Phenotypes for SLC45A4 Gene

GenomeRNAi human phenotypes for SLC45A4:
genes like me logo Genes that share phenotypes with SLC45A4: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC45A4 Gene

Localization for SLC45A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC45A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC45A4 gene
Compartment Confidence
plasma membrane 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC45A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC45A4: view

Pathways & Interactions for SLC45A4 Gene

SuperPathways for SLC45A4 Gene

No Data Available

Interacting Proteins for SLC45A4 Gene

Gene Ontology (GO) - Biological Process for SLC45A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015770 sucrose transport ISS --
genes like me logo Genes that share ontologies with SLC45A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC45A4 Gene

Drugs & Compounds for SLC45A4 Gene

No Compound Related Data Available

Transcripts for SLC45A4 Gene

Unigene Clusters for SLC45A4 Gene

Solute carrier family 45, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC45A4 Gene

No ASD Table

Relevant External Links for SLC45A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC45A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC45A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC45A4 Gene

This gene is overexpressed in Whole Blood (x7.9).

Protein differential expression in normal tissues from HIPED for SLC45A4 Gene

This gene is overexpressed in Pancreatic juice (52.0) and Placenta (17.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC45A4 Gene

Protein tissue co-expression partners for SLC45A4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC45A4 Gene:


SOURCE GeneReport for Unigene cluster for SLC45A4 Gene:


Evidence on tissue expression from TISSUES for SLC45A4 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SLC45A4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC45A4 Gene

Orthologs for SLC45A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC45A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC45A4 33 34
  • 98.86 (n)
(Canis familiaris)
Mammalia SLC45A4 33 34
  • 87.81 (n)
(Mus musculus)
Mammalia Slc45a4 33 16 34
  • 84.62 (n)
(Rattus norvegicus)
Mammalia Slc45a4 33
  • 84.49 (n)
(Bos Taurus)
Mammalia SLC45A4 33 34
  • 84.09 (n)
(Ornithorhynchus anatinus)
Mammalia SLC45A4 34
  • 79 (a)
(Monodelphis domestica)
Mammalia SLC45A4 34
  • 72 (a)
(Gallus gallus)
Aves SLC45A4 33 34
  • 74.4 (n)
(Anolis carolinensis)
Reptilia SLC45A4 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc45a4 33
  • 73.67 (n)
(Danio rerio)
Actinopterygii slc45a4 33 34
  • 62.27 (n)
SLC45A4 (1 of 2) 34
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Slc45-1 33
  • 50 (n)
CG41087 34
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010854 33
  • 49.4 (n)
Species where no ortholog for SLC45A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC45A4 Gene

Gene Tree for SLC45A4 (if available)
Gene Tree for SLC45A4 (if available)

Paralogs for SLC45A4 Gene

Paralogs for SLC45A4 Gene

(2) SIMAP similar genes for SLC45A4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC45A4: view

Variants for SLC45A4 Gene

Sequence variations from dbSNP and Humsavar for SLC45A4 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000015547 -- 141,273,689(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000038814 -- 141,288,821(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000053235 -- 141,209,196(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000104119 -- 141,214,522(-) A/G intron_variant
rs1000107027 -- 141,244,792(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC45A4 Gene

Variant ID Type Subtype PubMed ID
dgv1226e201 CNV deletion 23290073
esv1010766 CNV deletion 20482838
esv1087958 CNV insertion 17803354
esv1993873 CNV deletion 18987734
esv2737756 CNV deletion 23290073
esv2737763 CNV deletion 23290073
esv2737764 CNV deletion 23290073
esv2737766 CNV deletion 23290073
esv2737768 CNV deletion 23290073
esv2737769 CNV deletion 23290073
esv27607 CNV gain 19812545
esv3619058 CNV loss 21293372
esv3619059 CNV loss 21293372
esv6131 CNV gain 19470904
nsv1019363 CNV gain 25217958
nsv1125270 CNV insertion 24896259
nsv1125958 CNV tandem duplication 24896259
nsv1126125 CNV deletion 24896259
nsv465955 CNV loss 19166990
nsv470239 CNV loss 18288195
nsv473556 CNV novel sequence insertion 20440878
nsv478744 CNV novel sequence insertion 20440878
nsv512970 CNV insertion 21212237
nsv516666 CNV loss 19592680
nsv516911 CNV gain+loss 19592680
nsv522318 CNV loss 19592680
nsv612568 CNV gain 21841781
nsv612572 CNV loss 21841781
nsv612573 CNV gain 21841781
nsv612574 CNV loss 21841781
nsv6428 CNV insertion 18451855
nsv831483 CNV gain 17160897
nsv949995 CNV deletion 24416366

Variation tolerance for SLC45A4 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC45A4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC45A4 Gene

Disorders for SLC45A4 Gene

Additional Disease Information for SLC45A4

No disorders were found for SLC45A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC45A4 Gene

Publications for SLC45A4 Gene

  1. Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae. (PMID: 25164149) Bartölke R … Vitavska O (The Biochemical journal 2014) 2 3 58
  2. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 44 58
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for SLC45A4 Gene

Sources for SLC45A4 Gene

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