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Aliases for SLC45A4 Gene

Aliases for SLC45A4 Gene

  • Solute Carrier Family 45 Member 4 2 3 5
  • Solute Carrier Family 45, Member 4 2
  • KIAA1126 4

External Ids for SLC45A4 Gene

Previous GeneCards Identifiers for SLC45A4 Gene

  • GC08M142287
  • GC08M137532
  • GC08M142218

Summaries for SLC45A4 Gene

GeneCards Summary for SLC45A4 Gene

SLC45A4 (Solute Carrier Family 45 Member 4) is a Protein Coding gene. An important paralog of this gene is SLC45A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC45A4 Gene

Genomics for SLC45A4 Gene

Regulatory Elements for SLC45A4 Gene

Enhancers for SLC45A4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F141225 1.8 FANTOM5 Ensembl ENCODE 56.6 +80.8 80819 3.4 PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SLC45A4 DENND3 ENSG00000253307 LOC105375787 LINC01300 GPR20 PTP4A3 ENSG00000280035
GH08F141237 1.6 FANTOM5 Ensembl ENCODE 58.1 +68.7 68710 4.8 HDGF TBP WRNIP1 SIN3A BRCA1 RAD21 RFX5 RCOR1 FOS SMARCC1 SLC45A4 DENND3 ENSG00000253307 PTP4A3 ENSG00000280035
GH08F141205 1.5 FANTOM5 Ensembl ENCODE 46.1 +100.7 100710 4.8 PKNOX1 KLF17 SIN3A RAD21 ZSCAN9 ZNF143 ETV6 FOS MIER1 JUNB SLC45A4 DENND3 ENSG00000259891 ENSG00000253307 PIR43322 LOC105375785
GH08F141233 1.5 FANTOM5 Ensembl ENCODE 45.8 +73.2 73167 2.8 PKNOX1 ARID4B DMAP1 ZNF48 ELK1 FOS DEK MXD4 MIER3 SMARCA4 SLC45A4 DENND3 ENSG00000253307 PTP4A3 ENSG00000280035
GH08F141398 1.7 FANTOM5 Ensembl ENCODE 33.4 -94.6 -94586 8.9 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B YBX1 DMAP1 SLC30A9 ZNF143 SLC45A4 DENND3 LINC01300 ENSG00000244998 TRAPPC9 PTP4A3 PIR43419
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC45A4 on UCSC Golden Path with GeneCards custom track

Promoters for SLC45A4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001403595 610 3001 TBP ATF1 TBL1XR1 ZNF76 SIN3A GLIS2 ELK1 SCRT2 CREM EGR2

Genomic Location for SLC45A4 Gene

Chromosome:
8
Start:
141,207,166 bp from pter
End:
141,308,310 bp from pter
Size:
101,145 bases
Orientation:
Minus strand

Genomic View for SLC45A4 Gene

Genes around SLC45A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC45A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC45A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC45A4 Gene

Proteins for SLC45A4 Gene

  • Protein details for SLC45A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BKX6-S45A4_HUMAN
    Recommended name:
    Solute carrier family 45 member 4
    Protein Accession:
    Q5BKX6
    Secondary Accessions:
    • Q6ZRI2
    • Q9ULU3

    Protein attributes for SLC45A4 Gene

    Size:
    768 amino acids
    Molecular mass:
    83878 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH90891.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC45A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC45A4 Gene

Post-translational modifications for SLC45A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC45A4 Gene

Domains & Families for SLC45A4 Gene

Gene Families for SLC45A4 Gene

Protein Domains for SLC45A4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC45A4 Gene

Graphical View of Domain Structure for InterPro Entry

Q5BKX6

UniProtKB/Swiss-Prot:

S45A4_HUMAN :
  • Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
Family:
  • Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
genes like me logo Genes that share domains with SLC45A4: view

Function for SLC45A4 Gene

Gene Ontology (GO) - Molecular Function for SLC45A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008506 sucrose:proton symporter activity ISS --
genes like me logo Genes that share ontologies with SLC45A4: view

Phenotypes for SLC45A4 Gene

GenomeRNAi human phenotypes for SLC45A4:
genes like me logo Genes that share phenotypes with SLC45A4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC45A4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC45A4 Gene

Localization for SLC45A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC45A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC45A4 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC45A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC45A4: view

Pathways & Interactions for SLC45A4 Gene

SuperPathways for SLC45A4 Gene

No Data Available

Interacting Proteins for SLC45A4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000024061%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000160827%0d%0a
Selected Interacting proteins: ENSP00000024061 Q5BKX6-S45A4_HUMAN for SLC45A4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC45A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015770 sucrose transport ISS --
genes like me logo Genes that share ontologies with SLC45A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC45A4 Gene

Transcripts for SLC45A4 Gene

Unigene Clusters for SLC45A4 Gene

Solute carrier family 45, member 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC45A4 Gene

No ASD Table

Relevant External Links for SLC45A4 Gene

GeneLoc Exon Structure for
SLC45A4
ECgene alternative splicing isoforms for
SLC45A4

Expression for SLC45A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC45A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC45A4 Gene

This gene is overexpressed in Whole Blood (x7.9).

Protein differential expression in normal tissues from HIPED for SLC45A4 Gene

This gene is overexpressed in Pancreatic juice (52.0) and Placenta (17.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC45A4 Gene



Protein tissue co-expression partners for SLC45A4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC45A4 Gene:

SLC45A4

SOURCE GeneReport for Unigene cluster for SLC45A4 Gene:

Hs.372492
genes like me logo Genes that share expression patterns with SLC45A4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC45A4 Gene

Orthologs for SLC45A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC45A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC45A4 34 35
  • 98.86 (n)
dog
(Canis familiaris)
Mammalia SLC45A4 34 35
  • 87.81 (n)
mouse
(Mus musculus)
Mammalia Slc45a4 34 16 35
  • 84.62 (n)
rat
(Rattus norvegicus)
Mammalia Slc45a4 34
  • 84.49 (n)
cow
(Bos Taurus)
Mammalia SLC45A4 34 35
  • 84.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC45A4 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC45A4 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC45A4 34 35
  • 74.4 (n)
lizard
(Anolis carolinensis)
Reptilia SLC45A4 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc45a4 34
  • 73.67 (n)
zebrafish
(Danio rerio)
Actinopterygii slc45a4 34 35
  • 62.27 (n)
SLC45A4 (1 of 2) 35
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Slc45-1 34
  • 50 (n)
CG41087 35
  • 33 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010854 34
  • 49.4 (n)
Species where no ortholog for SLC45A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC45A4 Gene

ENSEMBL:
Gene Tree for SLC45A4 (if available)
TreeFam:
Gene Tree for SLC45A4 (if available)

Paralogs for SLC45A4 Gene

Paralogs for SLC45A4 Gene

(2) SIMAP similar genes for SLC45A4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC45A4: view

Variants for SLC45A4 Gene

Sequence variations from dbSNP and Humsavar for SLC45A4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10086136 -- 141,298,877(+) CTCCA(C/G)GCAGA intron-variant
rs10086563 -- 141,284,325(+) GGCAG(C/T)GTGCA intron-variant
rs10087637 -- 141,229,219(+) GTAAC(A/C)CACCC intron-variant, upstream-variant-2KB
rs10088627 -- 141,247,601(+) gaaac(A/G)aggtc intron-variant
rs10088801 -- 141,265,702(+) TGCTG(C/T)CGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC45A4 Gene

Variant ID Type Subtype PubMed ID
dgv1226e201 CNV deletion 23290073
esv1010766 CNV deletion 20482838
esv1087958 CNV insertion 17803354
esv1993873 CNV deletion 18987734
esv2737756 CNV deletion 23290073
esv2737763 CNV deletion 23290073
esv2737764 CNV deletion 23290073
esv2737766 CNV deletion 23290073
esv2737768 CNV deletion 23290073
esv2737769 CNV deletion 23290073
esv27607 CNV gain 19812545
esv3619058 CNV loss 21293372
esv3619059 CNV loss 21293372
esv6131 CNV gain 19470904
nsv1019363 CNV gain 25217958
nsv1125270 CNV insertion 24896259
nsv1125958 CNV tandem duplication 24896259
nsv1126125 CNV deletion 24896259
nsv465955 CNV loss 19166990
nsv470239 CNV loss 18288195
nsv473556 CNV novel sequence insertion 20440878
nsv478744 CNV novel sequence insertion 20440878
nsv512970 CNV insertion 21212237
nsv516666 CNV loss 19592680
nsv516911 CNV gain+loss 19592680
nsv522318 CNV loss 19592680
nsv612568 CNV gain 21841781
nsv612572 CNV loss 21841781
nsv612573 CNV gain 21841781
nsv612574 CNV loss 21841781
nsv6428 CNV insertion 18451855
nsv831483 CNV gain 17160897
nsv949995 CNV deletion 24416366

Variation tolerance for SLC45A4 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC45A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC45A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC45A4 Gene

Disorders for SLC45A4 Gene

Relevant External Links for SLC45A4

Genetic Association Database (GAD)
SLC45A4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC45A4

No disorders were found for SLC45A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC45A4 Gene

Publications for SLC45A4 Gene

  1. Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae. (PMID: 25164149) BartAPlke R. … Vitavska O. (Biochem. J. 2014) 2 3 64
  2. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3 46 64
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 46 64

Products for SLC45A4 Gene

Sources for SLC45A4 Gene

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