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Aliases for SLC45A3 Gene

Aliases for SLC45A3 Gene

  • Solute Carrier Family 45, Member 3 2 3
  • Prostate Cancer Associated Protein 6 2 3
  • Prostate Cancer Associated Protein 2 2 3
  • Prostate Cancer Associated Protein 8 2 3
  • Prostate Cancer-Associated Protein 6 3 4
  • Prostein 3 4
  • PCANAP6 3 4
  • PRST 3 4
  • Prostate Cancer-Associated Gene 2 3
  • Prostate Cancer-Associated Gene 6 3
  • Prostate Cancer-Associated Gene 8 3
  • PCANAP2 3
  • PCANAP8 3
  • IPCA-2 3
  • IPCA-6 3
  • IPCA-8 3
  • IPCA6 3

External Ids for SLC45A3 Gene

Previous HGNC Symbols for SLC45A3 Gene

  • PCANAP6
  • PCANAP2
  • PCANAP8

Previous GeneCards Identifiers for SLC45A3 Gene

  • GC01M202360
  • GC01M203893
  • GC01M176791

Summaries for SLC45A3 Gene

GeneCards Summary for SLC45A3 Gene

SLC45A3 (Solute Carrier Family 45, Member 3) is a Protein Coding gene. Diseases associated with SLC45A3 include prostate cancer. Among its related pathways are MicroRNAs in cancer and Transcriptional misregulation in cancer. An important paralog of this gene is SLC45A1.

Gene Wiki entry for SLC45A3 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC45A3 Gene

Genomics for SLC45A3 Gene

Regulatory Elements for SLC45A3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC45A3 Gene

Chromosome:
1
Start:
205,657,851 bp from pter
End:
205,680,502 bp from pter
Size:
22,652 bases
Orientation:
Minus strand

Genomic View for SLC45A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC45A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC45A3 Gene

Proteins for SLC45A3 Gene

  • Protein details for SLC45A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JT2-S45A3_HUMAN
    Recommended name:
    Solute carrier family 45 member 3
    Protein Accession:
    Q96JT2
    Secondary Accessions:
    • A8K2U9

    Protein attributes for SLC45A3 Gene

    Size:
    553 amino acids
    Molecular mass:
    59323 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for prostate carcinomas-directed cytotoxic T-cell lymphocytes

neXtProt entry for SLC45A3 Gene

Proteomics data for SLC45A3 Gene at MOPED

Post-translational modifications for SLC45A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC45A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC45A3 Gene

Domains & Families for SLC45A3 Gene

Gene Families for SLC45A3 Gene

Protein Domains for SLC45A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC45A3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96JT2

UniProtKB/Swiss-Prot:

S45A3_HUMAN :
  • Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
Family:
  • Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
genes like me logo Genes that share domains with SLC45A3: view

Function for SLC45A3 Gene

Molecular function for SLC45A3 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by androgens.
genes like me logo Genes that share phenotypes with SLC45A3: view

Animal Model Products

miRNA for SLC45A3 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC45A3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC45A3 Gene

Localization for SLC45A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC45A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC45A3 Gene COMPARTMENTS Subcellular localization image for SLC45A3 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for SLC45A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC45A3: view

Pathways & Interactions for SLC45A3 Gene

genes like me logo Genes that share pathways with SLC45A3: view

Pathways by source for SLC45A3 Gene

Interacting Proteins for SLC45A3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356113%0d%0a9606.ENSP00000363822%0d%0a
Selected Interacting proteins: ENSP00000356113 Q96JT2-S45A3_HUMAN for SLC45A3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC45A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC45A3: view

No data available for SIGNOR curated interactions for SLC45A3 Gene

Drugs & Compounds for SLC45A3 Gene

No Compound Related Data Available

Transcripts for SLC45A3 Gene

Unigene Clusters for SLC45A3 Gene

Solute carrier family 45, member 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC45A3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC45A3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2: -

Relevant External Links for SLC45A3 Gene

GeneLoc Exon Structure for
SLC45A3
ECgene alternative splicing isoforms for
SLC45A3

Expression for SLC45A3 Gene

mRNA expression in normal human tissues for SLC45A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC45A3 Gene

This gene is overexpressed in Prostate (x21.8).

Protein differential expression in normal tissues from HIPED for SLC45A3 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC45A3 Gene



SOURCE GeneReport for Unigene cluster for SLC45A3 Gene Hs.278695

mRNA Expression by UniProt/SwissProt for SLC45A3 Gene

Q96JT2-S45A3_HUMAN
Tissue specificity: Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and cancerous prostates.
genes like me logo Genes that share expression patterns with SLC45A3: view

Protein tissue co-expression partners for SLC45A3 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC45A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC45A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC45A3 35
  • 86.1 (n)
  • 89.44 (a)
SLC45A3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC45A3 35
  • 89.53 (n)
  • 93.1 (a)
SLC45A3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc45a3 35
  • 87.44 (n)
  • 90.94 (a)
Slc45a3 16
Slc45a3 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC45A3 35
  • 99.4 (n)
  • 99.46 (a)
SLC45A3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc45a3 35
  • 87.38 (n)
  • 91.85 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC45A3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC45A3 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC45A3 35
  • 70.12 (n)
  • 73.2 (a)
SLC45A3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc45a3 35
  • 59.27 (n)
  • 58.51 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68967 35
zebrafish
(Danio rerio)
Actinopterygii slc45a3 35
  • 57.7 (n)
  • 52.29 (a)
slc45a3 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG40467 36
  • 25 (a)
OneToMany
CG41343 36
  • 23 (a)
OneToMany
Slc45-1 36
  • 23 (a)
OneToMany
Species with no ortholog for SLC45A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC45A3 Gene

ENSEMBL:
Gene Tree for SLC45A3 (if available)
TreeFam:
Gene Tree for SLC45A3 (if available)

Paralogs for SLC45A3 Gene

Paralogs for SLC45A3 Gene

(1) SIMAP similar genes for SLC45A3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC45A3: view

Variants for SLC45A3 Gene

Sequence variations from dbSNP and Humsavar for SLC45A3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs868844 -- 205,677,518(+) TCCTC(A/G)TTTTA intron-variant
rs871454 -- 205,666,820(+) ACAGT(A/G)CCCCC intron-variant
rs1123879 -- 205,665,187(+) GGAGC(A/G)GGAGG intron-variant
rs1418549 -- 205,675,720(+) TCCAA(C/G)GTGGT intron-variant
rs1418652 -- 205,677,330(-) GGCCC(A/G)TAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC45A3 Gene

Variant ID Type Subtype PubMed ID
nsv4188 CNV Insertion 18451855
dgv518n71 CNV Loss 21882294
esv2721929 CNV Deletion 23290073
esv2721940 CNV Deletion 23290073

Variation tolerance for SLC45A3 Gene

Residual Variation Intolerance Score: 23.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC45A3 Gene

HapMap Linkage Disequilibrium report
SLC45A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC45A3 Gene

Disorders for SLC45A3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC45A3 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association

Relevant External Links for SLC45A3

Genetic Association Database (GAD)
SLC45A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC45A3
genes like me logo Genes that share disorders with SLC45A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC45A3 Gene

Publications for SLC45A3 Gene

  1. Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells. (PMID: 18193184) Musiyenko A. … Barik S. (J. Mol. Med. 2008) 23 67
  2. TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation. (PMID: 18542058) Sun C. … Srivastava S. (Oncogene 2008) 23 67
  3. [Molecular genetic markers for prostate cancer. Evidence in fine needle biopsies for improved confirmation of the diagnosis]. (PMID: 18679647) Schneider S. … Wirth M. (Urologe A 2008) 23 67
  4. Immunohistochemical detection of carcinoma in radical prostatectomy specimens following hormone therapy. (PMID: 18844933) Kusumi T. … Kijima H. (Pathol. Int. 2008) 23 67
  5. Prostatic adenocarcinoma in colorectal biopsy: clinical and pathologic features. (PMID: 18234278) Lane Z. … Netto G.J. (Hum. Pathol. 2008) 23 67

Products for SLC45A3 Gene

Sources for SLC45A3 Gene

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