Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC45A3 Gene

protein-coding   GIFtS: 59
GCID: GC01M205626

Solute Carrier Family 45, Member 3

(Previous names: prostate cancer associated protein 6, prostate cancer associated...)
(Previous symbols: PCANAP6, PCANAP2, PCANAP8)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 45, Member 31 2     IPCA-22
PCANAP61 2 3 5     IPCA-62
PRST2 3 5     IPCA-82
PCANAP21 2     Prostate Cancer-Associated Gene 22
PCANAP81 2     Prostate Cancer-Associated Gene 62
Prostate Cancer Associated Protein 21 2     Prostate Cancer-Associated Gene 82
Prostate Cancer Associated Protein 61 2     prostein2
Prostate Cancer Associated Protein 81 2     Solute Carrier Family 45 Member 32
Prostate Cancer-Associated Protein 62 3     Prostein3
IPCA62 5     

External Ids:    HGNC: 86421   Entrez Gene: 854142   Ensembl: ENSG000001587157   OMIM: 6050975   UniProtKB: Q96JT23   

Export aliases for SLC45A3 gene to outside databases

Previous GC identifers: GC01M202360 GC01M203893 GC01M176791


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC45A3 Gene: 
SLC45A3 (solute carrier family 45, member 3) is a protein-coding gene. Diseases associated with SLC45A3 include bladder adenocarcinoma, and ovarian mucinous adenocarcinoma. An important paralog of this gene is SLC45A1.

Gene Wiki entry for SLC45A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC45A3 gene promoter:
         GATA-3   Tal-1beta   POU3F2   NF-kappaB   NF-AT   GATA-2   GATA-1   NF-kappaB1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC45A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC45A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC45A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

SLC45A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC45A3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M205626:  view genomic region     (about GC identifiers)

Start:
205,626,979 bp from pter      End:
205,649,630 bp from pter
Size:
22,652 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S45A3_HUMAN, Q96JT2 (See protein sequence)
Recommended Name: Solute carrier family 45 member 3  
Size: 553 amino acids; 59323 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Miscellaneous: Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for
prostate carcinomas-directed cytotoxic T-cell lymphocytes

Explore the universe of human proteins at neXtProt for SLC45A3: NX_Q96JT2

Explore proteomics data for SLC45A3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96JT2

  • SLC45A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC45A3 Protein Expression
    REFSEQ proteins: NP_149093.1  
    ENSEMBL proteins: 
     ENSP00000356113  

    Human Recombinant Protein Products for SLC45A3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC45A3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SLC45A3
    GenScript Custom Purified and Recombinant Proteins Services for SLC45A3
    Novus Biologicals SLC45A3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC45A3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    SLC45A3 for ontologies           About GeneDecksing



    SLC45A3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SLC45A3
    OriGene Custom Antibody Services for SLC45A3
    GenScript Custom Superior Antibodies Services for SLC45A3
    Novus Biologicals SLC45A3 Antibodies
    Abcam antibodies for SLC45A3
    Cloud-Clone Corp. Antibodies for SLC45A3 
    ThermoFisher Antibodies for SLC45A3
    LSBio Antibodies in human, mouse, rat for SLC45A3 

    Assay Products for SLC45A3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC45A3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC45A3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLC45A3 
    Cloud-Clone Corp. CLIAs for SLC45A3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SLC45A3 
    SLC45 orphans

    2 InterPro protein domains:
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q96JT2

    ProtoNet protein and cluster: Q96JT2

    UniProtKB/Swiss-Prot: S45A3_HUMAN, Q96JT2
    Similarity: Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family


    SLC45A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S45A3_HUMAN, Q96JT2
    Induction: Up-regulated by androgens

    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC45A3:

     Decreased number of cells in m  Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC45A3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC45A3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC45A3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC45A3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC45A3:
    hsa-mir-138 (MIRT000797), hsa-mir-126 (MIRT001820), hsa-mir-126 (MIRT000798)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC45A3
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC45A3 (see all 36):
    hsa-miR-3664-5p hsa-miR-25 hsa-miR-218 hsa-miR-3667-5p hsa-miR-29a* hsa-miR-92b hsa-miR-3163 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidSLC45A3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC45A3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC45A3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC45A3
    Sirion Biotech Customized adenovirus for overexpression of SLC45A3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SLC45A3 (see all 8)
    OriGene ORF clones in mouse, rat for SLC45A3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC45A3 (NM_033102)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC45A3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC45A3
    Sirion Biotech Customized lentivirus for stable overexpression of SLC45A3 
                         Customized lentivirus expression plasmids for stable overexpression of SLC45A3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC45A3
    Search LifeMap BioReagents cell lines for SLC45A3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC45A3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    2MicroRNAs in cancer
    MicroRNAs in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for SLC45A3):
        Transcriptional misregulation in cancer
    MicroRNAs in cancer


    SLC45A3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC45A3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC45A3 (Q96JT23 ENSP000003561134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055085transmembrane transport IEA--

    SLC45A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC45A3 (S45A3)

    Search CenterWatch for drugs/clinical trials and news about SLC45A3 / S45A3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC45A3 gene: 
    NM_033102.2  

    Unigene Cluster for SLC45A3:

    Solute carrier family 45, member 3
    Hs.278695  [show with all ESTs]
    Unigene Representative Sequence: AY033593
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460934(uc010prn.1) ENST00000367145(uc010pro.1 uc010prp.1 uc001hda.1)


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC45A3
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC45A3 (see all 36):
    hsa-miR-3664-5p hsa-miR-25 hsa-miR-218 hsa-miR-3667-5p hsa-miR-29a* hsa-miR-92b hsa-miR-3163 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidSLC45A3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC45A3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC45A3
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC45A3 (see all 8)
    OriGene ORF clones in mouse, rat for SLC45A3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC45A3 (NM_033102)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC45A3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC45A3
    Sirion Biotech Customized lentivirus for stable overexpression of SLC45A3 
                         Customized lentivirus expression plasmids for stable overexpression of SLC45A3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC45A3
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC45A3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC45A3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC45A3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC45A3

    Additional mRNA sequence: 

    AK290364.1 AK313479.1 AL832933.1 AY033593.1 BC050416.2 EF632109.1 FJ805258.1 FJ805259.1 
    FJ805260.1 FJ805261.1 FJ805262.1 

    9 DOTS entries:

    DT.412459  DT.91953186  DT.121413002  DT.431616  DT.121412993  DT.102830791  DT.121412990  DT.91966403 
    DT.95176229 

    24/81 AceView cDNA sequences (see all 81):

    BQ950912 AA631024 CA489628 BU689021 AY033593 CD634715 CD634711 AI984307 
    NM_033102 CD634719 AI472447 AW135465 AL832933 BC050416 AA652651 AA112574 
    AA640153 BF222329 BF972601 CD634728 BQ082152 BG469889 BG469586 CD634729 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC45A3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:                                          
    SP2:                    -                     


    ECgene alternative splicing isoforms for SLC45A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC45A3 expression in normal human tissues (normalized intensities)      SLC45A3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATTTGAAC
    SLC45A3 Expression
    About this image


    SLC45A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
     
     Prostate (Endocrine System)    fully expand to see all 2 entries
             prostate ; glandular cells   
             prostate gland   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             spinal/ganglion/dorsal root ganglion   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See SLC45A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC45A3

    SOURCE GeneReport for Unigene cluster: Hs.278695

    UniProtKB/Swiss-Prot: S45A3_HUMAN, Q96JT2
    Tissue specificity: Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and
    cancerous prostates

        SABiosciences Custom PCR Arrays for SLC45A3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC45A3
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC45A3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC45A3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC45A3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC45A3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC45A3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc45a31 , 5 solute carrier family 45, member 31, 5 87.44(n)1
    90.94(a)1
      1 (57.24 cM)5
    2129801  NM_001177628.11  NP_001171099.11 
     1319629675 
    chicken
    (Gallus gallus)
    Aves SLC45A31 solute carrier family 45, member 3 69.99(n)
    72.83(a)
      771751  XM_001234995.1  XP_001234996.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC45A36
    --
    Uncharacterized protein
    68(a)
    58(a)
    1 ↔ many
    1 ↔ many
    GL343228.1(478273-525423)
    GL343228.1(467040-476175)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689672 hypothetical protein MGC68967 73.76(n)    BC059306.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:771581 zgc:77158 60.68(n)
    55.6(a)
      402971  NM_205672.1  NP_991235.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG413436
    CG404676
    (see all 3)
    --
    23(a)
    23(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    3LHet(911483-1053679)
    3LHet(722418-789756)


    ENSEMBL Gene Tree for SLC45A3 (if available)
    TreeFam Gene Tree for SLC45A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC45A3 gene
    SLC45A12  SLC45A42  SLC45A22  
    1 SIMAP similar gene for SLC45A3 using alignment to 2 protein entries:     S45A3_HUMAN (see all proteins):
    DKFZp666D0110

    SLC45A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/507 SNPs in SLC45A3 are shown (see all 507)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1510453051,2
    C--205626548(+) AGGCAC/TGCACC 1 -- int10--------
    rs1409303391,2
    --205626733(+) AAATGC/TCACCA 1 -- int10--------
    rs1849449791,2
    --205626816(+) AACCCC/TCCACA 1 -- int10--------
    rs1894037071,2
    --205626861(+) CTCCAC/TCTGCT 1 -- int10--------
    rs741431491,2
    C,F--205626886(+) AGTGAA/CGCTGT 1 -- int13Minor allele frequency- C:0.06WA CSA 122
    rs355041761,2
    C,F--205626904(+) CAAAGG/AGCTCC 1 -- int18Minor allele frequency- A:0.15NA WA EA 368
    rs342445651,2
    C,F--205626995(+) GAAAGC/GCTTTA 1 -- ut318Minor allele frequency- G:0.15NA CSA WA EA 368
    rs1140274881,2
    C,F--205627030(+) TCTGAT/CTGCTC 1 -- ut311Minor allele frequency- C:0.03WA 118
    rs1502834841,2
    --205627092(+) CAAACA/GGCACT 1 -- ut310--------
    rs343995971,2
    C,F--205627102(+) TTAAAC/-CCCCC 1 -- ut312Minor allele frequency- -:0.50NA CSA 4

    HapMap Linkage Disequilibrium report for SLC45A3 (205626979 - 205649630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC45A3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2721929CNV Deletion23290073
    esv2721940CNV Deletion23290073
    nsv4188CNV Insertion18451855
    dgv518n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC45A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC45A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605097    OMIM disorders: --

    11 diseases for SLC45A3:    About MalaCards
    bladder adenocarcinoma    ovarian mucinous adenocarcinoma    mucinous adenocarcinoma    prostate cancer
    prostatitis    small cell carcinoma    prostate adenocarcinoma    adenocarcinoma
    parkinson's disease    adenoma    endotheliitis

    3 diseases from the University of Copenhagen DISEASES database for SLC45A3:
    Prostate cancer     Ovarian mucinous adenocarcinoma     Bladder adenocarcinoma

    SLC45A3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for SLC45A3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 66.2 6 15048720 (3), 18193184 (2), 14997204 (1)
    tumors 24.9 5 16921506 (2), 18542058 (1), 17667550 (1), 18996329 (1)

    Genetic Association Database (GAD): SLC45A3

    Export disorders for SLC45A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC45A3 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with SLC45A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of prostein, a novel prostate-specific protein. (PubMed id 11245466)1, 2, 3 Xu J....Reed S.G. (2001)
    2. Identification of an HLA-A(*)0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein. (PubMed id 14997204)1, 2, 9 Kiessling A.... Schmitz M. (2004)
    3. Identification of nine novel loci associated with whi te blood cell subtypes in a Japanese population. (PubMed id 21738478)1, 4 Okada Y....Kamatani N. (2011)
    4. Genome-wide association study identifies common varia nts at four loci as genetic risk factors for Parkinson's disease. (PubMed id 19915576)1, 4 Satake W....Toda T. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Identification of naturally processed CD8 T cell epitopes from prostein, a prostate tissue-specific vaccine candidate. (PubMed id 15048720)1, 9 Friedman R.S....Kalos M. (2004)
    7. Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells. (PubMed id 18193184)1, 9 Musiyenko A....Barik S. (2008)
    8. Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population. (PubMed id 23269536)1 Sun J....Mo Z. (2013)
    9. Loss of SLC45A3 protein (prostein) expression in prost ate cancer is associated with SLC45A3-ERG gene rearrangement and an unfavorable clinical course. (PubMed id 22821757)1 Perner S....Kristiansen G. (2013)
    10. Chimeric transcript generated by cis-splicing of adjac ent genes regulates prostate cancer cell proliferation. (PubMed id 22719019)1 Zhang Y....Li H. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85414 HGNC: 8642 AceView: Prostein Ensembl:ENSG00000158715 euGenes: HUgn85414
    ECgene: SLC45A3 Kegg: 85414 H-InvDB: SLC45A3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC45A3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC45A3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC45A3 gene:
    Search GeneIP for patents involving SLC45A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SLC45A3   OriGene RNAi products in human, mouse, rat for SLC45A3  
     OriGene qPCR primer pairs and template standards for SLC45A3   OriGene Protein Over-expression Lysate for SLC45A3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC45A3  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC45A3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC45A3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC45A3   OriGene Custom Protein Services for SLC45A3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC45A3
     QIAGEN SeqTarget long-range PCR primers for resequencing SLC45A3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC45A3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC45A3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC45A3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC45A3
     GenScript Custom Purified and Recombinant Proteins Services for SLC45A3 GenScript cDNA clones with any tag delivered in your preferred vector for SLC45A3
     GenScript Custom Assay Services for SLC45A3 GenScript Custom Superior Antibodies Services for SLC45A3
     GenScript Custom overexpressing Cell Line Services for SLC45A3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC45A3 promoter
     Search Chromatin IP Primers for SLC45A3
     RT2 qPCR Primer Assay in human, mouse, rat SLC45A3
     Search GNC Networks for SLC45A3
     SABiosciences Custom PCR Arrays for SLC45A3
     Search Tocris compounds for SLC45A3 (S45A3)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC45A3 antibodies
     SLC45A3 lysates
     Antibodies for SLC45A3
     See all of Abcam's Antibodies, Kits and Proteins for SLC45A3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SLC45A3
     Antibodies for SLC45A3
     ELISAs for SLC45A3
     CLIAs for SLC45A3
     Search LifeMap BioReagents cell lines for SLC45A3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A3
     SwitchGear 3'UTR luciferase reporter plasmids for SLC45A3
     SwitchGear Promoter luciferase reporter plasmids for SLC45A3
     ThermoFisher Antibodies for SLC45A3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC45A3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC45A3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC45A3
    Customized:
     lentivirus for stable overexpression of SLC45A3
     lentivirus expression plasmids for stable overexpression of SLC45A3
     adenovirus for overexpression of SLC45A3
     LSBio Antibodies in human, mouse, rat for SLC45A3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC45A3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4