Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC45A3 Gene

protein-coding   GIFtS: 57
GCID: GC01M205626

Solute Carrier Family 45, Member 3

(Previous names: prostate cancer associated protein 6, prostate cancer associated...)
(Previous symbols: PCANAP6, PCANAP2, PCANAP8)
  See SLC45A3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 45, Member 31 2     IPCA-22
PCANAP61 2 3 5     IPCA-62
PRST2 3 5     IPCA-82
PCANAP21 2     Prostate Cancer-Associated Gene 22
PCANAP81 2     Prostate Cancer-Associated Gene 62
Prostate Cancer Associated Protein 21 2     Prostate Cancer-Associated Gene 82
Prostate Cancer Associated Protein 61 2     prostein2
Prostate Cancer Associated Protein 81 2     Solute Carrier Family 45 Member 32
Prostate Cancer-Associated Protein 62 3     Prostein3
IPCA62 5     

External Ids:    HGNC: 86421   Entrez Gene: 854142   Ensembl: ENSG000001587157   OMIM: 6050975   UniProtKB: Q96JT23   

Export aliases for SLC45A3 gene to outside databases

Previous GC identifers: GC01M202360 GC01M203893 GC01M176791


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SLC45A3 Gene:
SLC45A3 (solute carrier family 45, member 3) is a protein-coding gene. Diseases associated with SLC45A3 include bladder adenocarcinoma, and ovarian mucinous adenocarcinoma. An important paralog of this gene is SLC45A4.

Gene Wiki entry for SLC45A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC45A3 gene promoter:
         GATA-3   Tal-1beta   POU3F2   NF-kappaB   NF-AT   GATA-2   GATA-1   NF-kappaB1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC45A3 promoter sequence
   Search Chromatin IP Primers for SLC45A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC45A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

SLC45A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC45A3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M205626:  view genomic region     (about GC identifiers)

Start:
205,626,979 bp from pter      End:
205,649,630 bp from pter
Size:
22,652 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: S45A3_HUMAN, Q96JT2 (See protein sequence)
Recommended Name: Solute carrier family 45 member 3  
Size: 553 amino acids; 59323 Da
Miscellaneous: Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for
prostate carcinomas-directed cytotoxic T-cell lymphocytes

Explore the universe of human proteins at neXtProt for SLC45A3: NX_Q96JT2

Explore proteomics data for SLC45A3 at MOPED


See SLC45A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_149093.1  
ENSEMBL proteins: 
 ENSP00000356113  

SLC45A3 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for SLC45A3
OriGene Custom MassSpec
OriGene Custom Protein Services for SLC45A3
GenScript Custom Purified and Recombinant Proteins Services for SLC45A3
Novus Biologicals SLC45A3 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for SLC45A3

 
Search eBioscience for Proteins for SLC45A3 

SLC45A3 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for SLC45A3
OriGene Custom Antibody Services for SLC45A3
Novus Biologicals SLC45A3 Antibodies
Abcam antibodies for SLC45A3
Cloud-Clone Corp. Antibodies for SLC45A3
ThermoFisher Antibodies for SLC45A3
LSBio Antibodies in human, mouse, rat for SLC45A3

SLC45A3 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for SLC45A3
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for SLC45A3
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for SLC45A3
Cloud-Clone Corp. CLIAs for SLC45A3
Search eBioscience for ELISAs for SLC45A3 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: SLC45A3
SLC45 orphans

2 InterPro protein domains:
 IPR011701 MFS
 IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry Q96JT2

ProtoNet protein and cluster: Q96JT2

UniProtKB/Swiss-Prot: S45A3_HUMAN, Q96JT2
Similarity: Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family


Find genes that share domains with SLC45A3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: S45A3_HUMAN, Q96JT2
Induction: Up-regulated by androgens

Phenotypes:
     2 GenomeRNAi human phenotypes for SLC45A3:

 Decreased number of cells in m  Decreased viability of wild-ty 

     1 MGI phenotypic allele for Slc45a3 (no phenotypes)

Find genes that share phenotypes with SLC45A3           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC45A3
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC45A3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC45A3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC45A3

miRNA
Products:
    
miRTarBase miRNAs that target SLC45A3:
hsa-mir-138-5p (MIRT000797), hsa-mir-126-5p (MIRT001820), hsa-mir-126-3p (MIRT000798), hsa-mir-32-5p (MIRT006716)

Block miRNA regulation of human, mouse, rat SLC45A3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SLC45A3 (see all 36):
hsa-miR-3664-5p hsa-miR-25 hsa-miR-218 hsa-miR-3667-5p hsa-miR-29a* hsa-miR-92b hsa-miR-3163 hsa-miR-4324
SwitchGear 3'UTR luciferase reporter plasmidSLC45A3 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for SLC45A3
Predesigned siRNA for gene silencing in human, mouse, rat SLC45A3

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for SLC45A3

Clone
Products:
     
OriGene clones in human, mouse for SLC45A3 (see all 7)
OriGene ORF clones in mouse, rat for SLC45A3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SLC45A3 (NM_033102)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC45A3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC45A3

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for SLC45A3
Browse ESI BIO Cell Lines and PureStem Progenitors for SLC45A3 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
S45A3_HUMAN, Q96JT2: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3
nucleus2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with SLC45A3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for SLC45A3 About    
See pathways by source

SuperPathContained pathways About
1Transcriptional misregulation in cancer
Transcriptional misregulation in cancer
2MicroRNAs in cancer
MicroRNAs in cancer


Find genes that share SuperPaths with SLC45A3           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



2 Kegg Pathways  (Kegg details for SLC45A3):
    Transcriptional misregulation in cancer
MicroRNAs in cancer

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC45A3
Interactions:

    Search GeneGlobe Interaction Network for SLC45A3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SLC45A3 (Q96JT23 ENSP000003561134) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0055085transmembrane transport IEA--

Find genes that share ontologies with SLC45A3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SLC45A3 (S45A3)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for SLC45A3 gene: 
NM_033102.2  

Unigene Cluster for SLC45A3:

Solute carrier family 45, member 3
Hs.278695  [show with all ESTs]
Unigene Representative Sequence: AY033593
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000460934(uc010prn.1) ENST00000367145(uc010pro.1 uc010prp.1 uc001hda.1)

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat SLC45A3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SLC45A3 (see all 36):
hsa-miR-3664-5p hsa-miR-25 hsa-miR-218 hsa-miR-3667-5p hsa-miR-29a* hsa-miR-92b hsa-miR-3163 hsa-miR-4324
SwitchGear 3'UTR luciferase reporter plasmidSLC45A3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for SLC45A3
Predesigned siRNA for gene silencing in human, mouse, rat SLC45A3
Clone
Products:
     
OriGene clones in human, mouse for SLC45A3 (see all 7)
OriGene ORF clones in mouse, rat for SLC45A3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SLC45A3 (NM_033102)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC45A3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC45A3
Primer
Products:
    
OriGene qPCR primer pairs and template standards for SLC45A3
OriGene qSTAR qPCR primer pairs in human, mouse for SLC45A3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC45A3
  QuantiTect SYBR Green Assays in human, mouse, rat SLC45A3
  QuantiFast Probe-based Assays in human, mouse, rat SLC45A3

Additional mRNA sequence: 

AK290364.1 AK313479.1 AL832933.1 AY033593.1 BC050416.2 EF632109.1 FJ805258.1 FJ805259.1 
FJ805260.1 FJ805261.1 FJ805262.1 

9 DOTS entries:

DT.412459  DT.91953186  DT.121413002  DT.431616  DT.121412993  DT.102830791  DT.121412990  DT.91966403 
DT.95176229 

Selected AceView cDNA sequences (see all 81):

BC050416 AA112574 AA631024 BU689021 CD634719 CD634711 CD634715 AL832933 
AI984307 AI472447 AY033593 BQ950912 CA489628 NM_033102 AW135465 AA652651 
CD634726 BF446419 CD634729 BF972601 AI703348 BQ948390 AA640153 BE867241 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC45A3    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:                                          
SP2:                    -                     


ECgene alternative splicing isoforms for SLC45A3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

SLC45A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGATTTGAAC
SLC45A3 Expression
About this image


SLC45A3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Neural Tube (Nervous System)    fully expand to see all 4 entries
         Mesencephalic Ventricular Zone
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Myelinating Oligodendrocyte Cells Forebrain White Matter
         Cerebral Cortex
 
 Thymus (Hematopoietic System)
         Thymus
 
 Ovary (Reproductive System)
         Secondary follicles
 
 Testis (Reproductive System)
SLC45A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLC45A3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.278695

UniProtKB/Swiss-Prot: S45A3_HUMAN, Q96JT2
Tissue specificity: Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and
cancerous prostates

    Custom PCR Arrays for SLC45A3
Primer
Products:
OriGene qPCR primer pairs and template standards for SLC45A3
OriGene qSTAR qPCR primer pairs in human, mouse for SLC45A3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC45A3
QuantiTect SYBR Green Assays in human, mouse, rat SLC45A3
QuantiFast Probe-based Assays in human, mouse, rat SLC45A3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for SLC45A3 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc45a31 , 5 solute carrier family 45, member 31, 5 87.44(n)1
90.94(a)1
  1 (57.24 cM)5
2129801  NM_001177628.21  NP_001171099.11 
 1319629675 
chicken
(Gallus gallus)
Aves SLC45A31 solute carrier family 45, member 3 70.12(n)
73.2(a)
  771751  XM_004934942.1  XP_004934999.1 
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
67(a)
60(a)
1 ↔ many
1 ↔ many
GL343228.1(478273-525423)
GL343228.1(467040-476175)
African clawed frog
(Xenopus laevis)
Amphibia MGC689672 hypothetical protein MGC68967 73.76(n)    BC059306.1 
zebrafish
(Danio rerio)
Actinopterygii slc45a31 solute carrier family 45, member 3 57.7(n)
52.29(a)
  100049157  NM_001098195.1  NP_001091665.1 
fruit fly
(Drosophila melanogaster)
Insecta CG404676
Slc45-16
(see all 3)
Slc45 ortholog 1
(see all 3)
25(a)
23(a)
(see all 3)
1 ↔ many
1 ↔ many
(see all 3)
3LHet(722418-789756)
3L(9196165-9201953)


ENSEMBL Gene Tree for SLC45A3 (if available)
TreeFam Gene Tree for SLC45A3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for SLC45A3 gene
SLC45A42  SLC45A12  SLC45A22  
1 SIMAP similar gene for SLC45A3 using alignment to 2 protein entries:     S45A3_HUMAN (see all proteins):
DKFZp666D0110

Find genes that share paralogs with SLC45A3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for SLC45A3 (see all 507)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1510453051,2
C--205626548(+) AGGCAC/TGCACC 1 -- int10--------
rs1409303391,2
--205626733(+) AAATGC/TCACCA 1 -- int10--------
rs1849449791,2
--205626816(+) AACCCC/TCCACA 1 -- int10--------
rs1894037071,2
--205626861(+) CTCCAC/TCTGCT 1 -- int10--------
rs741431491,2
C,F--205626886(+) AGTGAA/CGCTGT 1 -- int13Minor allele frequency- C:0.06WA CSA 122
rs355041761,2
C,F--205626904(+) CAAAGG/AGCTCC 1 -- int18Minor allele frequency- A:0.15NA WA EA 368
rs342445651,2
C,F--205626995(+) GAAAGC/GCTTTA 1 -- ut318Minor allele frequency- G:0.15NA CSA WA EA 368
rs1140274881,2
C,F--205627030(+) TCTGAT/CTGCTC 1 -- ut311Minor allele frequency- C:0.03WA 118
rs1502834841,2
--205627092(+) CAAACA/GGCACT 1 -- ut310--------
rs343995971,2
C,F--205627102(+) TTAAAC/-CCCCC 1 -- ut312Minor allele frequency- -:0.50NA CSA 4

HapMap Linkage Disequilibrium report for SLC45A3 (205626979 - 205649630 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for SLC45A3:    About this table    
Variant IDTypeSubtypePubMed ID
esv2721929CNV Deletion23290073
esv2721940CNV Deletion23290073
nsv4188CNV Insertion18451855
dgv518n71CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SLC45A3
DNA2.0 Custom Variant and Variant Library Synthesis for SLC45A3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 605097    OMIM disorders: --

4 diseases for SLC45A3:    
About MalaCards
bladder adenocarcinoma    ovarian mucinous adenocarcinoma    villous adenoma    prostate cancer

3 diseases from the University of Copenhagen DISEASES database for SLC45A3:
Prostate cancer     Ovarian mucinous adenocarcinoma     Bladder adenocarcinoma

Find genes that share disorders with SLC45A3           About GenesLikeMe

2 Novoseek inferred disease relationships for SLC45A3 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer 66.2 6 15048720 (3), 18193184 (2), 14997204 (1)
tumors 24.9 5 16921506 (2), 18542058 (1), 17667550 (1), 18996329 (1)

Genetic Association Database (GAD): SLC45A3

Export disorders for SLC45A3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for SLC45A3 gene, integrated from 10 sources (see all 36):
(articles sorted by number of sources associating them with SLC45A3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of prostein, a novel prostate- specific protein. (PubMed id 11245466)1, 2, 3 Xu J.... Reed S.G. (Cancer Res. 2001)
  2. Identification of an HLA-A(*)0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein. (PubMed id 14997204)1, 2, 9 Kiessling A.... Schmitz M. (Br. J. Cancer 2004)
  3. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PubMed id 21738478)1, 4 Okada Y....Kamatani N. (PLoS Genet. 2011)
  4. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. (PubMed id 19915576)1, 4 Satake W....Toda T. (Nat. Genet. 2009)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Identification of naturally processed CD8 T cell epitopes from prostein, a prostate tissue-specific vaccine candidate. (PubMed id 15048720)1, 9 Friedman R.S....Kalos M. (Eur. J. Immunol. 2004)
  7. Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells. (PubMed id 18193184)1, 9 Musiyenko A....Barik S. (J. Mol. Med. 2008)
  8. Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population. (PubMed id 23269536)1 Sun J....Mo Z. (Hum. Genet. 2013)
  9. Loss of SLC45A3 protein (prostein) expression in prostate cancer is associated with SLC45A3-ERG gene rearrangement and an unfavorable clinical course. (PubMed id 22821757)1 Perner S....Kristiansen G. (Int. J. Cancer 2013)
  10. Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation. (PubMed id 22719019)1 Zhang Y....Li H. (Cancer Discov 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 85414 HGNC: 8642 AceView: Prostein Ensembl:ENSG00000158715 euGenes: HUgn85414
ECgene: SLC45A3 Kegg: 85414 H-InvDB: SLC45A3

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for SLC45A3 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SLC45A3 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for SLC45A3 gene:
Search GeneIP for patents involving SLC45A3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for SLC45A3   OriGene RNAi products in human, mouse, rat for SLC45A3  
 OriGene qPCR primer pairs and template standards for SLC45A3   OriGene Protein Over-expression Lysate for SLC45A3  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC45A3  
 OriGene qSTAR qPCR primer pairs in human, mouse for SLC45A3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for SLC45A3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for SLC45A3   OriGene Custom Protein Services for SLC45A3  

 
 
 Block miRNA regulation of human, mouse, rat SLC45A3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC45A3
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC45A3 Predesigned siRNA for gene silencing in human, mouse, rat SLC45A3
 QuantiFast Probe-based Assays in human, mouse, rat SLC45A3 QuantiTect SYBR Green Assays in human, mouse, rat SLC45A3
 Custom PCR Arrays for SLC45A3 Search Chromatin IP Primers for SLC45A3
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC45A3  Search GeneGlobe Interaction Network for SLC45A3
 Regulatory tfbs in SLC45A3 promoter
 GenScript Custom Purified and Recombinant Proteins Services for SLC45A3 GenScript cDNA clones with any tag delivered in your preferred vector for SLC45A3
 GenScript Custom Assay Services for SLC45A3 GenScript Custom overexpressing Cell Line Services for SLC45A3
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for SLC45A3 (S45A3)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 SLC45A3 antibodies
 SLC45A3 lysates
 Antibodies for SLC45A3
 See all of Abcam's Antibodies, Kits and Proteins for SLC45A3
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for SLC45A3
 Antibodies for SLC45A3
 ELISAs for SLC45A3
 CLIAs for SLC45A3



 Browse ESI BIO Cell Lines and PureStem Progenitors for SLC45A3
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A3
 SwitchGear 3'UTR luciferase reporter plasmids for SLC45A3
 SwitchGear Promoter luciferase reporter plasmids for SLC45A3
 ThermoFisher Antibodies for SLC45A3
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC45A3
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC45A3
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC45A3
 LSBio Antibodies in human, mouse, rat for SLC45A3
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for SLC45A3
  Search eBioscience for proteins for SLC45A3
  Search eBioscience for elisas for SLC45A3
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      SLC45A3 gene at Home site.
Version: 3.12.212 17 Sep 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4