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Aliases for SLC45A3 Gene

Aliases for SLC45A3 Gene

  • Solute Carrier Family 45 Member 3 2 3 5
  • Prostate Cancer Associated Protein 6 2 3
  • Prostate Cancer Associated Protein 2 2 3
  • Prostate Cancer Associated Protein 8 2 3
  • Prostein 3 4
  • PCANAP6 3 4
  • PRST 3 4
  • Prostate Cancer-Associated Protein 6 4
  • Solute Carrier Family 45, Member 3 2
  • Prostate Cancer-Associated Gene 2 3
  • Prostate Cancer-Associated Gene 6 3
  • Prostate Cancer-Associated Gene 8 3
  • PCANAP2 3
  • PCANAP8 3
  • IPCA-2 3
  • IPCA-6 3
  • IPCA-8 3
  • IPCA6 3

External Ids for SLC45A3 Gene

Previous HGNC Symbols for SLC45A3 Gene

  • PCANAP6
  • PCANAP2
  • PCANAP8

Previous GeneCards Identifiers for SLC45A3 Gene

  • GC01M202360
  • GC01M203893
  • GC01M176791

Summaries for SLC45A3 Gene

GeneCards Summary for SLC45A3 Gene

SLC45A3 (Solute Carrier Family 45 Member 3) is a Protein Coding gene. Diseases associated with SLC45A3 include Prostate Cancer and Suppression Of Tumorigenicity 12. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. An important paralog of this gene is SLC45A1.

Gene Wiki entry for SLC45A3 Gene

Additional gene information for SLC45A3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC45A3 Gene

Genomics for SLC45A3 Gene

GeneHancer (GH) Regulatory Elements for SLC45A3 Gene

Promoters and enhancers for SLC45A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I205674 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 552.2 +2.6 2637 6.3 HDGF PKNOX1 SMAD1 FOXA2 ARNT SIN3A ZNF2 ZNF766 FOS SP3 SLC45A3 PM20D1 RAB29 TMCC2 CDK18 MFSD4A DSTYK LOC105371701 ELK4
GH01I205667 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 38 +10.2 10153 4.8 HDGF CLOCK FOXA2 ARID4B SIN3A IRF4 ETS1 ZNF143 ATF7 RUNX3 SLC45A3 RAB29 RNU6-418P NUCKS1 ELK4 LOC100420878 MFSD4A CDK18 PM20D1 LOC105371701
GH01I205710 Enhancer 1.1 Ensembl ENCODE 13 -30.8 -30775 1 FOXA2 YY1 GATA2 ARID2 ZNF143 FOS ATF7 RXRA NCOA1 REST PM20D1 RAB29 SLC45A3 NUCKS1 RNU6-418P MFSD4A RNU2-19P ELK4 LOC100420878 ENSG00000201944
GH01I205700 Enhancer 0.8 Ensembl ENCODE 14.1 -20.8 -20798 0.9 MAZ ZNF680 HLF ZNF398 ZIC2 NFIC POLR2A ZBTB48 GLIS1 PATZ1 RAB29 SLC45A3 RNU6-418P NUCKS1 MFSD4A ELK4 LOC100420878 ENSG00000201944
GH01I205706 Enhancer 0.8 ENCODE 13 -26.4 -26416 0.8 HDAC1 TCF12 ZNF766 ATF7 CEBPB ZEB2 NR2F2 NFIC MTA1 SMARCA4 PM20D1 SLC45A3 RNU6-418P MFSD4A ELK4 LOC100420878 RAB29 NUCKS1 ENSG00000201944
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC45A3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC45A3 gene promoter:

Genomic Locations for SLC45A3 Gene

Genomic Locations for SLC45A3 Gene
chr1:205,657,851-205,680,502
(GRCh38/hg38)
Size:
22,652 bases
Orientation:
Minus strand
chr1:205,626,979-205,649,630
(GRCh37/hg19)

Genomic View for SLC45A3 Gene

Genes around SLC45A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC45A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC45A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC45A3 Gene

Proteins for SLC45A3 Gene

  • Protein details for SLC45A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JT2-S45A3_HUMAN
    Recommended name:
    Solute carrier family 45 member 3
    Protein Accession:
    Q96JT2
    Secondary Accessions:
    • A8K2U9

    Protein attributes for SLC45A3 Gene

    Size:
    553 amino acids
    Molecular mass:
    59323 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for prostate carcinomas-directed cytotoxic T-cell lymphocytes.

neXtProt entry for SLC45A3 Gene

Post-translational modifications for SLC45A3 Gene

No Post-translational modifications

Other Protein References for SLC45A3 Gene

No data available for DME Specific Peptides for SLC45A3 Gene

Domains & Families for SLC45A3 Gene

Gene Families for SLC45A3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC45A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC45A3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96JT2

UniProtKB/Swiss-Prot:

S45A3_HUMAN :
  • Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
Family:
  • Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
genes like me logo Genes that share domains with SLC45A3: view

Function for SLC45A3 Gene

Molecular function for SLC45A3 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by androgens.

Phenotypes From GWAS Catalog for SLC45A3 Gene

Gene Ontology (GO) - Molecular Function for SLC45A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008506 sucrose:proton symporter activity ISS,IEA --
GO:0051119 sugar transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC45A3: view
genes like me logo Genes that share phenotypes with SLC45A3: view

Animal Model Products

miRNA for SLC45A3 Gene

Clone Products

  • R&D Systems cDNA Clones for SLC45A3 (SLC45A3/Prostein)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC45A3 Gene

Localization for SLC45A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC45A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC45A3 gene
Compartment Confidence
plasma membrane 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC45A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC45A3: view

Pathways & Interactions for SLC45A3 Gene

genes like me logo Genes that share pathways with SLC45A3: view

Pathways by source for SLC45A3 Gene

Interacting Proteins for SLC45A3 Gene

Gene Ontology (GO) - Biological Process for SLC45A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008645 hexose transport TAS --
GO:0010907 positive regulation of glucose metabolic process IEA,ISS --
GO:0015770 sucrose transport ISS,IEA --
GO:0034219 carbohydrate transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC45A3: view

No data available for SIGNOR curated interactions for SLC45A3 Gene

Drugs & Compounds for SLC45A3 Gene

No Compound Related Data Available

Transcripts for SLC45A3 Gene

Unigene Clusters for SLC45A3 Gene

Solute carrier family 45, member 3:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for SLC45A3 (SLC45A3/Prostein)

Alternative Splicing Database (ASD) splice patterns (SP) for SLC45A3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2: -

Relevant External Links for SLC45A3 Gene

GeneLoc Exon Structure for
SLC45A3
ECgene alternative splicing isoforms for
SLC45A3

Expression for SLC45A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC45A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC45A3 Gene

This gene is overexpressed in Prostate (x21.8).

Protein differential expression in normal tissues from HIPED for SLC45A3 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC45A3 Gene



Protein tissue co-expression partners for SLC45A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC45A3 Gene:

SLC45A3

SOURCE GeneReport for Unigene cluster for SLC45A3 Gene:

Hs.278695

mRNA Expression by UniProt/SwissProt for SLC45A3 Gene:

Q96JT2-S45A3_HUMAN
Tissue specificity: Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and cancerous prostates.

Evidence on tissue expression from TISSUES for SLC45A3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SLC45A3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC45A3 Gene

Orthologs for SLC45A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC45A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC45A3 33 34
  • 99.4 (n)
dog
(Canis familiaris)
Mammalia SLC45A3 33 34
  • 89.53 (n)
mouse
(Mus musculus)
Mammalia Slc45a3 33 16 34
  • 87.44 (n)
rat
(Rattus norvegicus)
Mammalia Slc45a3 33
  • 87.38 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC45A3 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC45A3 33 34
  • 86.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC45A3 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC45A3 33 34
  • 70.12 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 67 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc45a3 33
  • 59.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68967 33
zebrafish
(Danio rerio)
Actinopterygii slc45a3 33 34
  • 57.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG40467 34
  • 25 (a)
OneToMany
CG41343 34
  • 23 (a)
OneToMany
Slc45-1 34
  • 23 (a)
OneToMany
Species where no ortholog for SLC45A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC45A3 Gene

ENSEMBL:
Gene Tree for SLC45A3 (if available)
TreeFam:
Gene Tree for SLC45A3 (if available)

Paralogs for SLC45A3 Gene

Paralogs for SLC45A3 Gene

(1) SIMAP similar genes for SLC45A3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC45A3: view

Variants for SLC45A3 Gene

Sequence variations from dbSNP and Humsavar for SLC45A3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000303709 -- 205,675,187(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000346554 -- 205,662,919(-) A/T coding_sequence_variant, missense_variant
rs1000465648 -- 205,678,564(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000557988 -- 205,680,470(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000575142 -- 205,673,702(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC45A3 Gene

Variant ID Type Subtype PubMed ID
esv2721929 CNV deletion 23290073
esv2721940 CNV deletion 23290073
nsv1126227 CNV deletion 24896259
nsv4188 CNV insertion 18451855

Variation tolerance for SLC45A3 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC45A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC45A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC45A3 Gene

Disorders for SLC45A3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC45A3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, susceptibility to
suppression of tumorigenicity 12
  • st12
male reproductive organ cancer
  • male genital cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC45A3

genes like me logo Genes that share disorders with SLC45A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC45A3 Gene

Publications for SLC45A3 Gene

  1. Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein. (PMID: 14997204) Kiessling A … Schmitz M (British journal of cancer 2004) 3 4 22 58
  2. Identification and characterization of prostein, a novel prostate-specific protein. (PMID: 11245466) Xu J … Reed SG (Cancer research 2001) 2 3 4 58
  3. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PMID: 21738478) Okada Y … Kamatani N (PLoS genetics 2011) 3 44 58
  4. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. (PMID: 19915576) Satake W … Toda T (Nature genetics 2009) 3 44 58
  5. Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells. (PMID: 18193184) Musiyenko A … Barik S (Journal of molecular medicine (Berlin, Germany) 2008) 3 22 58

Products for SLC45A3 Gene

Sources for SLC45A3 Gene

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