SLC45A3 Gene
protein-coding GIFtS : 54
GCID: GC01 M205626
solute carrier family 45, member 3 (Previous names: prostate cancer associated protein 6, prostate cancer associated... ) (Previous symbols: PCANAP6, PCANAP2, PCANAP8 )
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Aliasesfor SLC45A3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Solute Carrier Family 45, Member 3 1 2 Prostate Cancer Associated Protein 81 2 PCANAP61 2 3 5 Prostein3 PRST2 3 5 Prostate Cancer-Associated Protein 62 3 IPCA-21 2 IPCA62 5 IPCA-61 2 Prostate Cancer-Associated Gene 22 IPCA-81 2 Prostate Cancer-Associated Gene 62 PCANAP21 2 Prostate Cancer-Associated Gene 82 PCANAP81 2 Solute Carrier Family 45 Member 32 Prostate Cancer Associated Protein 21 2 Prostein3 Prostate Cancer Associated Protein 61 2
Export aliases for SLC45A3 gene to outside databases Previous GC identifers: GC01M202360 GC01M203893 GC01M176791
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Summariesfor SLC45A3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for SLC45A3
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Genomic Viewsfor SLC45A3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004487.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SLC45A3 gene promoter: GATA-3 Tal-1beta POU3F2 NF-kappaB NF-AT GATA-2 GATA-1 NF-kappaB1 ITF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for SLC45A3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SLC45A3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1 SLC45A3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M205626: view genomic region
(about GC identifiers )
Start:
205,626,979 bp from pter
End:
205,649,630 bp from pter
Size:
22,652 bases
Orientation:
minus strand
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Proteinsfor SLC45A3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: S45A3_HUMAN, Q96JT2 (See
protein sequence )Recommended Name: Solute carrier family 45 member 3 Size : 553 amino acids; 59323 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Miscellaneous : Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for prostatecarcinomas-directed cytotoxic T-cell lymphocytes Explore the universe of human proteins at neXtProt for SLC45A3: NX_Q96JT2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96JT2 SLC45A3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_149093.1 ENSEMBL proteins: ENSP00000356113 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
SLC45A3 for ontologies About GeneDecksing SLC45A3 Antibody Products: Assay Products for SLC45A3:
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Protein
Domains / Familiesfor SLC45A3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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SLC45A3 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96JT2 ProtoNet protein and cluster: Q96JT2
UniProtKB/Swiss-Prot: S45A3_HUMAN, Q96JT2 Similarity : Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family
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Functionfor SLC45A3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: S45A3_HUMAN, Q96JT2 Induction : Up-regulated by androgens
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC45A3 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC45A3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SLC45A3 (NM_033102 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC45A3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC45A3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A3
2 GenomeRNAi human phenotypes for SLC45A3 :
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Pathways & Interactionsfor SLC45A3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC45A3 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for SLC45A3 (Q96JT2 3 ENSP00000356113 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0055085 transmembrane transport
IEA --
SLC45A3 for ontologies About GeneDecksing
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Drugs & Compoundsfor SLC45A3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SLC45A3 Search CenterWatch for drugs/clinical trials and news about SLC45A3 / S45A3
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Transcriptsfor SLC45A3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SLC45A3 gene: NM_033102.2 Unigene Cluster for SLC45A3:
Solute carrier family 45, member 3 Hs.278695 [show with all ESTs ] Unigene Representative Sequence: AY033593 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000460934 (uc010prn.1 ) ENST00000367145 (uc010pro.1 uc010prp.1 uc001hda.1 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC45A3 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC45A3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SLC45A3 (NM_033102 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC45A3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC45A3
Additional cDNA sequence: AK290364.1 AK313479.1 AL832933.1 AY033593.1 BC050416.2 EF632109.1 FJ805258.1 FJ805259.1 FJ805260.1 FJ805261.1 FJ805262.1
9 DOTS entries : DT.412459 DT.91953186
DT.121413002 DT.431616 DT.121412993 DT.102830791 DT.121412990 DT.91966403 DT.95176229 24/81 AceView cDNA sequences (see all 81 ):
CA489628 NM_033102 AY033593 CD634711 AI984307 CD634715 BQ950912 AW135465 CD634719 AA112574 AA652651 AA631024 BU689021 BC050416 AL832933 AI472447 AA984323 CD634724 BF972601 BG469889 AI969820 BE674096 CD634726 CD634717 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC45A3 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 SP1 :               SP2 :       -        
ECgene alternative splicing isoforms for SLC45A3
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Expression for SLC45A3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SLC45A3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGATTTGAAC
About this image SLC45A3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SLC45A3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SLC45A3 SOURCE GeneReport for Unigene cluster: Hs.278695 UniProtKB/Swiss-Prot: S45A3_HUMAN, Q96JT2 Tissue specificity : Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal andcancerous prostates SABiosciences Custom PCR Arrays for SLC45A3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SLC45A3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SLC45A3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SLC45A3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SLC45A3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A3
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Orthologsfor SLC45A3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC45A3 gene from 6/19 species (see all 19 ) About this table
ENSEMBL Gene Tree for SLC45A3 (if available)TreeFam Gene Tree for SLC45A3 (if available)
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Paralogsfor SLC45A3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SLC45A3 gene SLC45A1 2 SLC45A4 2 SLC45A2 2 1 SIMAP similar gene for SLC45A3 using alignment to 2 protein entries: S45A3_HUMAN (see all proteins ):DKFZp666D0110
SLC45A3 for paralogs About GeneDecksing
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Genomic Variantsfor SLC45A3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SLC45A3 (205626979 - 205649630 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SLC45A3: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SLC45A3
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Disorders
/ Diseasesfor SLC45A3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SLC45A3 for disorders About GeneDecksing
OMIM gene information: 605097
OMIM disorders : --12 diseases for SLC45A3 : About MalaCards prostate cancer prostatitis ovarian mucinous adenocarcinoma mucinous adenocarcinoma small cell carcinoma bladder adenocarcinoma adenocarcinoma parkinson's disease prostate adenocarcinoma prostate carcinoma adenoma carcinoma 3 diseases from the University of Copenhagen DISEASES database for SLC45A3 :Ovarian mucinous adenocarcinoma Prostate cancer Bladder adenocarcinoma 2 Novoseek disease relationships for SLC45A3 gene About this table
Export disorders for SLC45A3 gene to outside databases
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Publicationsfor SLC45A3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SLC45A3 gene, integrated from 9 sources (see all 34 ): (articles sorted by number of sources associating them with SLC45A3) Utopia : connect your pdf to the dynamic world of online information
Identification and characterization of prostein, a novel prostate-specific protein. (PubMed id 11245466) 1 , 2 , 3 Xu J....Reed S.G. (2001) Identification of an HLA-A(*)0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein. (PubMed id 14997204) 1 , 2 , 9 Kiessling A.... Schmitz M. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Identification of naturally processed CD8 T cell epitopes from prostein, a prostate tissue-specific vaccine candidate. (PubMed id 15048720) 1 , 9 Friedman R.S....Kalos M. (2004) Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells. (PubMed id 18193184) 1 , 9 Musiyenko A....Barik S. (2008) Loss of SLC45A3 protein (prostein) expression in prost ate cancer is associated with SLC45A3-ERG gene rearrangement and an unfavorable clinical course. (PubMed id 22821757) 1 Perner S....Kristiansen G. (2013) Chimeric transcript generated by cis-splicing of adjac ent genes regulates prostate cancer cell proliferation. (PubMed id 22719019) 1 Zhang Y....Li H. (2012) Diagnostic utility of p63/P501S double sequential imm unohistochemical staining in differentiating urothelial carcinoma from prostate carcinoma. (PubMed id 21777423) 1 Srinivasan M. and Parwani A.V. (2011) Identification of nine novel loci associated with whi te blood cell subtypes in a Japanese population. (PubMed id 21738478) 1 Okada Y....Kamatani N. (2011) Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusion s in a large prostatectomy cohort. (PubMed id 20118910) 1 Esgueva R....Rubin M.A. (2010)
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External Searches for SLC45A3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SLC45A3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SLC45A3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SLC45A3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for SLC45A3 gene: Search GeneIP for patents involving SLC45A3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SLC45A3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for SLC45A3 OriGene shRNA RFP for SLC45A3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SLC45A3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SLC45A3 OriGene Protein Over-expression Lysate for SLC45A3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SLC45A3 OriGene 3'-UTR Clone for SLC45A3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC45A3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC45A3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SLC45A3 OriGene Custom Protein Services for SLC45A3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC45A3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SLC45A3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SLC45A3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SLC45A3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SLC45A3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SLC45A3
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SLC45A3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A3
ThermoFisher Antibodies for SLC45A3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC45A3
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Aliases for SLC45A3
Databases for SLC45A3
Disorders / Diseases for SLC45A3
Domains / Families for SLC45A3
Drugs / Compounds for SLC45A3
Expression for SLC45A3
Function for SLC45A3
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Intellectual Property for SLC45A3
Orthologs for SLC45A3
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Proteins for SLC45A3
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