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Aliases for SLC45A3 Gene

Aliases for SLC45A3 Gene

  • Solute Carrier Family 45, Member 3 2 3
  • PCANAP6 3 4 6
  • PRST 3 4 6
  • Prostate Cancer Associated Protein 6 2 3
  • Prostate Cancer Associated Protein 2 2 3
  • Prostate Cancer Associated Protein 8 2 3
  • Prostate Cancer-Associated Protein 6 3 4
  • Prostein 3 4
  • IPCA6 3 6
  • Prostate Cancer-Associated Gene 2 3
  • Prostate Cancer-Associated Gene 6 3
  • Prostate Cancer-Associated Gene 8 3
  • Solute Carrier Family 45 Member 3 3
  • PCANAP2 3
  • PCANAP8 3
  • IPCA-2 3
  • IPCA-6 3
  • IPCA-8 3

External Ids for SLC45A3 Gene

Previous Symbols for SLC45A3 Gene

  • PCANAP6
  • PCANAP2
  • PCANAP8

Summaries for SLC45A3 Gene

GeneCards Summary for SLC45A3 Gene

SLC45A3 (Solute Carrier Family 45, Member 3) is a Protein Coding gene. Diseases associated with SLC45A3 include prostate cancer and ovarian mucinous adenocarcinoma. Among its related pathways are MicroRNAs in cancer and Transcriptional misregulation in cancer. An important paralog of this gene is SLC45A1.

Gene Wiki entry for SLC45A3 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC45A3 Gene

Genomics for SLC45A3 Gene

Genomic Location for SLC45A3 Gene

Start:
205,657,851 bp from pter
End:
205,680,502 bp from pter
Size:
22,652 bases
Orientation:
Minus strand

Genomic View for SLC45A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC45A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC45A3 Gene

Regulatory Elements for SLC45A3 Gene

Proteins for SLC45A3 Gene

  • Protein details for SLC45A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JT2-S45A3_HUMAN
    Recommended name:
    Solute carrier family 45 member 3
    Protein Accession:
    Q96JT2
    Secondary Accessions:
    • A8K2U9

    Protein attributes for SLC45A3 Gene

    Size:
    553 amino acids
    Molecular mass:
    59323 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for prostate carcinomas-directed cytotoxic T-cell lymphocytes

neXtProt entry for SLC45A3 Gene

Proteomics data for SLC45A3 Gene at MOPED

Post-translational modifications for SLC45A3 Gene

No Post-translational modifications

Other Protein References for SLC45A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC45A3 Gene

Domains for SLC45A3 Gene

Gene Families for SLC45A3 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC45A3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

S45A3_HUMAN
Family:
  • Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.:
    • Q96JT2
genes like me logo Genes that share domains with SLC45A3: view

Function for SLC45A3 Gene

Molecular function for SLC45A3 Gene

UniProtKB/Swiss-Prot Induction: Up-regulated by androgens.
genes like me logo Genes that share phenotypes with SLC45A3: view

miRNA for SLC45A3 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC45A3 Gene

Localization for SLC45A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC45A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC45A3 Gene COMPARTMENTS Subcellular localization image for SLC45A3 gene
Compartment Confidence
plasma membrane 3
nucleus 2

Gene Ontology (GO) - Cellular Components for SLC45A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC45A3: view

Pathways for SLC45A3 Gene

genes like me logo Genes that share pathways with SLC45A3: view

Pathways by source for SLC45A3 Gene

Interacting Proteins for SLC45A3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356113%0d%0a9606.ENSP00000363822%0d%0a
Selected Interacting proteins: ENSP00000356113 Q96JT2-S45A3_HUMAN for SLC45A3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC45A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC45A3: view

Transcripts for SLC45A3 Gene

Unigene Clusters for SLC45A3 Gene

Solute carrier family 45, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC45A3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2: -

Relevant External Links for SLC45A3 Gene

GeneLoc Exon Structure for
SLC45A3
ECgene alternative splicing isoforms for
SLC45A3

Expression for SLC45A3 Gene

mRNA expression in normal human tissues for SLC45A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC45A3 Gene

This gene is overexpressed in Prostate (21.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC45A3 Gene

SOURCE GeneReport for Unigene cluster for SLC45A3 Gene Hs.278695

mRNA Expression by UniProt/SwissProt for SLC45A3 Gene

Q96JT2-S45A3_HUMAN
Tissue specificity: Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and cancerous prostates.
genes like me logo Genes that share expressions with SLC45A3: view

Orthologs for SLC45A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC45A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC45A3 36
  • 99.4 (n)
  • 99.46 (a)
SLC45A3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC45A3 36
  • 86.1 (n)
  • 89.44 (a)
SLC45A3 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC45A3 36
  • 89.53 (n)
  • 93.1 (a)
SLC45A3 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc45a3 36
  • 87.44 (n)
  • 90.94 (a)
Slc45a3 16
Slc45a3 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC45A3 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC45A3 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc45a3 36
  • 87.38 (n)
  • 91.85 (a)
chicken
(Gallus gallus)
Aves SLC45A3 36
  • 70.12 (n)
  • 73.2 (a)
SLC45A3 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 60 (a)
OneToMany
-- 37
  • 67 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC68967 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc45a3 36
  • 59.27 (n)
  • 58.51 (a)
zebrafish
(Danio rerio)
Actinopterygii slc45a3 36
  • 57.7 (n)
  • 52.29 (a)
slc45a3 37
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG40467 37
  • 25 (a)
OneToMany
CG41343 37
  • 23 (a)
OneToMany
Slc45-1 37
  • 23 (a)
OneToMany
Species with no ortholog for SLC45A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC45A3 Gene

ENSEMBL:
Gene Tree for SLC45A3 (if available)
TreeFam:
Gene Tree for SLC45A3 (if available)

Paralogs for SLC45A3 Gene

Paralogs for SLC45A3 Gene

Selected SIMAP similar genes for SLC45A3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC45A3: view

Variants for SLC45A3 Gene

Sequence variations from dbSNP and Humsavar for SLC45A3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs868844 -- 205,677,518(+) TCCTC(A/G)TTTTA intron-variant
rs1418549 -- 205,675,720(+) TCCAA(C/G)GTGGT intron-variant
rs1772134 -- 205,682,385(-) GGCAC(C/G)ATCTC upstream-variant-2KB
rs1772135 -- 205,682,355(-) ctccc(A/G)ggttc upstream-variant-2KB
rs1772137 -- 205,680,199(-) GCCGG(A/G)GCGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC45A3 Gene

Variant ID Type Subtype PubMed ID
nsv4188 CNV Insertion 18451855
dgv518n71 CNV Loss 21882294
esv2721929 CNV Deletion 23290073
esv2721940 CNV Deletion 23290073

Relevant External Links for SLC45A3 Gene

HapMap Linkage Disequilibrium report
SLC45A3

Disorders for SLC45A3 Gene

(3) University of Copenhagen DISEASES for SLC45A3 Gene

(2) Novoseek inferred disease relationships for SLC45A3 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 66.2 6
tumors 24.9 5

Relevant External Links for SLC45A3

Genetic Association Database (GAD)
SLC45A3
genes like me logo Genes that share disorders with SLC45A3: view

No data available for UniProtKB/Swiss-Prot for SLC45A3 Gene

Publications for SLC45A3 Gene

  1. Identification of an HLA-A(*)0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein. (PMID: 14997204) Kiessling A. … Schmitz M. (Br. J. Cancer 2004) 3 4 23
  2. Identification and characterization of prostein, a novel prostate- specific protein. (PMID: 11245466) Xu J. … Reed S.G. (Cancer Res. 2001) 2 3 4
  3. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. (PMID: 19915576) Satake W. … Toda T. (Nat. Genet. 2009) 3 49
  4. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PMID: 21738478) Okada Y. … Kamatani N. (PLoS Genet. 2011) 3 49
  5. Identification of naturally processed CD8 T cell epitopes from prostein, a prostate tissue-specific vaccine candidate. (PMID: 15048720) Friedman R.S. … Kalos M. (Eur. J. Immunol. 2004) 3 23

Products for SLC45A3 Gene

  • antibodies-online peptides for SLC45A3
  • antibodies-online antibodies for SLC45A3
  • antibodies-online kits for SLC45A3

Sources for SLC45A3 Gene

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