Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC45A1 Gene

Aliases for SLC45A1 Gene

  • Solute Carrier Family 45, Member 1 2 3
  • DNB5 3 4 6
  • Deleted In Neuroblastoma 5 Protein 3 4
  • H+/Sugar Symporter 2 3
  • PAST-A 3 4
  • Proton-Associated Sugar Transporter A 3
  • Solute Carrier Family 45 Member 1 4
  • Deleted In Neuroblastoma 5 2
  • DNb-5 4

External Ids for SLC45A1 Gene

Previous HGNC Symbols for SLC45A1 Gene

  • DNB5

Previous GeneCards Identifiers for SLC45A1 Gene

  • GC01P008313
  • GC01P008300
  • GC01P007532
  • GC01P008377

Summaries for SLC45A1 Gene

Entrez Gene Summary for SLC45A1 Gene

  • This gene was isolated initially from a region on chromosome 1p that is frequently deleted in human neuroblastoma, although no causal relationship has since been demonstrated. The encoded protein belongs to the glycoside-pentoside-hexuronide cation symporter transporter family and may play a role in glucose uptake. [provided by RefSeq, Mar 2014]

GeneCards Summary for SLC45A1 Gene

SLC45A1 (Solute Carrier Family 45, Member 1) is a Protein Coding gene. Diseases associated with SLC45A1 include neuroblastoma. GO annotations related to this gene include symporter activity. An important paralog of this gene is SLC45A3.

UniProtKB/Swiss-Prot for SLC45A1 Gene

  • Mediates glucose uptake along the pH gradient.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC45A1 Gene

Genomics for SLC45A1 Gene

Regulatory Elements for SLC45A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC45A1 Gene

8,317,826 bp from pter
8,344,167 bp from pter
26,342 bases
Plus strand

Genomic View for SLC45A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC45A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC45A1 Gene

Proteins for SLC45A1 Gene

  • Protein details for SLC45A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proton-associated sugar transporter A
    Protein Accession:
    Secondary Accessions:
    • Q5VY46
    • Q5VY49

    Protein attributes for SLC45A1 Gene

    748 amino acids
    Molecular mass:
    80843 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD27583.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAH70515.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SLC45A1 Gene

Proteomics data for SLC45A1 Gene at MOPED

Post-translational modifications for SLC45A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC45A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC45A1 Gene

Domains for SLC45A1 Gene

Gene Families for SLC45A1 Gene

  • SLC :Solute carriers

Protein Domains for SLC45A1 Gene


Suggested Antigen Peptide Sequences for SLC45A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y2W3
  • Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
genes like me logo Genes that share domains with SLC45A1: view

Function for SLC45A1 Gene

Molecular function for SLC45A1 Gene

UniProtKB/Swiss-Prot Function:
Mediates glucose uptake along the pH gradient.

Gene Ontology (GO) - Molecular Function for SLC45A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC45A1: view

Phenotypes for SLC45A1 Gene

GenomeRNAi human phenotypes for SLC45A1:
genes like me logo Genes that share phenotypes with SLC45A1: view

Animal Model Products

CRISPR Products

miRNA for SLC45A1 Gene

miRTarBase miRNAs that target SLC45A1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC45A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC45A1 Gene

Localization for SLC45A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC45A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC45A1 Gene COMPARTMENTS Subcellular localization image for SLC45A1 gene
Compartment Confidence
plasma membrane 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC45A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC45A1: view

Pathways for SLC45A1 Gene

SuperPathways for SLC45A1 Gene

No Data Available

Interacting Proteins for SLC45A1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000289877 for SLC45A1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SLC45A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC45A1: view

No data available for Pathways by source for SLC45A1 Gene

Transcripts for SLC45A1 Gene

mRNA/cDNA for SLC45A1 Gene

Unigene Clusters for SLC45A1 Gene

Solute carrier family 45, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC45A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC45A1 Gene

No ASD Table

Relevant External Links for SLC45A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC45A1 Gene

mRNA expression in normal human tissues for SLC45A1 Gene

SOURCE GeneReport for Unigene cluster for SLC45A1 Gene Hs.463036

mRNA Expression by UniProt/SwissProt for SLC45A1 Gene

Tissue specificity: Expressed in adult heart, brain, muscle and kidney, with very strong expression in brain. Also expressed in fetal brain, kidney and lung
genes like me logo Genes that share expressions with SLC45A1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for SLC45A1 Gene

Orthologs for SLC45A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC45A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC45A1 35
  • 87.39 (n)
  • 90.11 (a)
SLC45A1 36
  • 89 (a)
(Canis familiaris)
Mammalia SLC45A1 35
  • 87.91 (n)
  • 89.99 (a)
SLC45A1 36
  • 88 (a)
(Mus musculus)
Mammalia Slc45a1 35
  • 85.45 (n)
  • 91.03 (a)
Slc45a1 16
Slc45a1 36
  • 91 (a)
(Pan troglodytes)
Mammalia SLC45A1 35
  • 99.24 (n)
  • 99.87 (a)
SLC45A1 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Slc45a1 35
  • 85.77 (n)
  • 90.76 (a)
(Monodelphis domestica)
Mammalia SLC45A1 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia SLC45A1 36
  • 78 (a)
(Gallus gallus)
Aves SLC45A1 35
  • 72.56 (n)
  • 80.03 (a)
-- 36
  • 78 (a)
-- 36
  • 79 (a)
(Anolis carolinensis)
Reptilia SLC45A1 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc45a1 35
  • 67.89 (n)
  • 76.96 (a)
Str.15583 35
(Danio rerio)
Actinopterygii slc45a1 36
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000137 35
  • 54.75 (n)
  • 41.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG41087 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for SLC45A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC45A1 Gene

Gene Tree for SLC45A1 (if available)
Gene Tree for SLC45A1 (if available)

Paralogs for SLC45A1 Gene

Paralogs for SLC45A1 Gene

Selected SIMAP similar genes for SLC45A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC45A1: view

Variants for SLC45A1 Gene

Sequence variations from dbSNP and Humsavar for SLC45A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs186175 -- 8,335,681(+) CCCTT(C/T)CCAGA intron-variant
rs503079 -- 8,330,601(-) GGCCG(C/T)GCCAA reference, missense
rs516345 -- 8,344,174(+) GGTTT(C/T)TAGGC downstream-variant-500B
rs573729 -- 8,343,015(+) TGGGC(C/G)TGATT intron-variant
rs668886 -- 8,330,543(-) ATGAA(A/G)CTGCC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SLC45A1 Gene

Variant ID Type Subtype PubMed ID
nsv871164 CNV Loss 21882294
nsv1743 CNV Insertion 18451855
nsv516827 CNV Loss 19592680
esv1250756 CNV Insertion 17803354

Relevant External Links for SLC45A1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC45A1 Gene

Disorders for SLC45A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC45A1 Gene in MalaCards »

(1) Diseases for SLC45A1 Gene including...

genes like me logo Genes that share disorders with SLC45A1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SLC45A1 Gene

Publications for SLC45A1 Gene

  1. Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP. (PMID: 10729226) Amler L.C. … Hampton G.M. (Genomics 2000) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Protein phosphatase 1I+ interacting proteins in the human brain. (PMID: 22321011) Esteves S.L. … da Cruz e Silva E.F. (OMICS 2012) 3
  4. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PMID: 23453885) (Lancet 2013) 3
  5. Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. (PMID: 24823311) Guan W. … Steffen L.M. (Circ Cardiovasc Genet 2014) 3

Products for SLC45A1 Gene

Sources for SLC45A1 Gene

Back to Top