SLC45A1 Gene
protein-coding GIFtS: 43
GCID: GC01P008377
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solute carrier family 45, member 1(Previous name: deleted in neuroblastoma 5 )
(Previous symbol: DNB5)
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Aliases
for SLC45A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 45, Member 11 2 | | PAST-A2 3 | | DNB51 2 3 5 | | Deleted In Neuroblastoma 51 | | Deleted In Neuroblastoma 5 Protein2 3 | | Proton-Associated Sugar Transporter A2 | | DNb-52 3 | | Solute Carrier Family 45 Member 13 |
Export aliases for SLC45A1 gene to outside databasesPrevious GC identifers: GC01P008313 GC01P008300 GC01P007532 |
Summaries
for SLC45A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: S45A1_HUMAN, Q9Y2W3Function: Mediates glucose uptake along the pH gradient (By similarity)
|
Genomic Views
for SLC45A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC45A1 gene promoter:
USF1 Sp1 AML1a Pax-2 Pax-2a GATA-2 NRF-2 USF-1 SEF-1 (1) c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC45A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC45A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.23 Ensembl cytogenetic band: 1p36.23 HGNC cytogenetic band: 1p36.23SLC45A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P008377: view genomic region
(about GC identifiers)
Start:
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8,377,886 bp from pter |
End:
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8,404,227 bp from pter |
Size:
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26,342 bases |
Orientation:
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plus strand |
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Proteins
for SLC45A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S45A1_HUMAN, Q9Y2W3 (See
protein sequence)Recommended Name: Proton-associated sugar transporter A Size: 748 amino acids; 80843 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAD27583.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;Sequence=CAH70515.2; Type=Erroneous gene model prediction;
Secondary accessions: Q5VY46 Q5VY49Explore the universe of human proteins at neXtProt for SLC45A1: NX_Q9Y2W3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2W3
SLC45A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073866.1
ENSEMBL proteins: ENSP00000418096 ENSP00000366699 ENSP00000289877
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC45A1 for ontologies About GeneDecksing
SLC45A1 Antibody Products:
Assay Products for SLC45A1: |
Protein
Domains /
Families
for SLC45A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC45A1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2W3ProtoNet protein and cluster: Q9Y2W3 UniProtKB/Swiss-Prot: S45A1_HUMAN, Q9Y2W3Similarity: Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family |
Function
for SLC45A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S45A1_HUMAN, Q9Y2W3Function: Mediates glucose uptake along the pH gradient (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC45A1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC45A1
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005355 | glucose transmembrane transporter activity |
-- | -- | | GO:0015293 | symporter activity |
IEA | -- |
SLC45A1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SLC45A1:
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Pathways & Interactions
for SLC45A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC45A1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SLC45A1 (ENSP000002898774) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008643 | carbohydrate transport |
IEA | -- | | GO:0015758 | glucose transport |
-- | -- |
SLC45A1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC45A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC45A1
Search CenterWatch for drugs/clinical trials and news about SLC45A1 / S45A1
|
Transcripts
for SLC45A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC45A1 gene: NM_001080397.1 Unigene Cluster for SLC45A1: Solute carrier family 45, member 1 Hs.463036 [show with all ESTs]Unigene Representative Sequence: NM_0010803975 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000471889 ENST00000497660(uc001apc.3) ENST00000481265 ENST00000377479
ENST00000289877(uc001apb.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC45A1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC45A1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC45A1 (NM_001080397) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC45A1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC45A1 |
Additional cDNA sequence: AF118274.1 2 DOTS entries: DT.40214842 DT.208435 24/32 AceView cDNA sequences (see all 32): AI567491 BM700954 CD513284 BU527858 AW294950 BX951580 BM693417 AI198006 BM543646 AW071730 BF062396 CD671127 BG201041 BQ187552 AI341392 AI479747 AI928533 BM668694 BF364660 AA974225 BG207837 AI627430 AI983304 BE703512
GeneLoc Exon Structure
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Expression
for SLC45A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC45A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SLC45A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC45A1
SOURCE GeneReport for Unigene cluster: Hs.463036
UniProtKB/Swiss-Prot: S45A1_HUMAN, Q9Y2W3Tissue specificity: Expressed in adult heart, brain, muscle and kidney, with very strong expression in brain. Alsoexpressed in fetal brain, kidney and lung
SABiosciences Custom PCR Arrays for SLC45A1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC45A1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC45A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC45A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC45A1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A1 |
Orthologs
for SLC45A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC45A1 gene from 7/24 species (see all 24) About this table
ENSEMBL Gene Tree for SLC45A1 (if available)
TreeFam Gene Tree for SLC45A1 (if available) |
Paralogs
for SLC45A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC45A1 gene
- SLC45A42 SLC45A32 SLC45A22
1 SIMAP similar gene for SLC45A1 using alignment to 1 protein entry: S45A1_HUMAN:SLC45A4
SLC45A1 for paralogs About GeneDecksing
|
Genomic Variants
for SLC45A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC45A1 (8377886 - 8404227 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SLC45A1
3 CNVs: 48369 48368 48370 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC45A1 |
|
Disorders
/ Diseases
for SLC45A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC45A1 for disorders About GeneDecksing
OMIM gene information: 605763
OMIM disorders: --
3  diseases for SLC45A1: About MalaCardsneuroblastoma neuroblastoma 5 neuronitis
Export disorders for SLC45A1 gene to outside databases
|
Publications
for SLC45A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC45A1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC45A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP. (PubMed id 10729226)1, 2, 3 Amler L.C....Hampton G.M. (2000)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
- Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain. (PubMed id 12417639)9 Shimokawa N....Miura M. (2002)
- Molecular responses to acidosis of central chemosensitive neurons in brain. (PubMed id 15763422)9 Shimokawa N....Koibuchi N. (2005)
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External Searches for SLC45A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SLC45A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC45A1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC45A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SLC45A1 gene:
Search GeneIP for patents involving SLC45A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC45A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | SLC45A1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC45A1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC45A1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC45A1 |
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