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Aliases for SLC44A5 Gene

Aliases for SLC44A5 Gene

  • Solute Carrier Family 44, Member 5 2 3
  • CTL5 3 4
  • Choline Transporter-Like Protein 5 3
  • Solute Carrier Family 44 Member 5 4

External Ids for SLC44A5 Gene

Previous GeneCards Identifiers for SLC44A5 Gene

  • GC01M075385
  • GC01M075667
  • GC01M073802

Summaries for SLC44A5 Gene

GeneCards Summary for SLC44A5 Gene

SLC44A5 (Solute Carrier Family 44, Member 5) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. An important paralog of this gene is SLC44A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC44A5 Gene

Genomics for SLC44A5 Gene

Regulatory Elements for SLC44A5 Gene

Genomic Location for SLC44A5 Gene

75,202,131 bp from pter
75,611,116 bp from pter
408,986 bases
Minus strand

Genomic View for SLC44A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC44A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC44A5 Gene

Proteins for SLC44A5 Gene

  • Protein details for SLC44A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Choline transporter-like protein 5
    Protein Accession:
    Secondary Accessions:
    • B5MCU3
    • Q4G0K0
    • Q8NA44
    • Q8NB86

    Protein attributes for SLC44A5 Gene

    719 amino acids
    Molecular mass:
    81674 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC03655.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC44A5 Gene


neXtProt entry for SLC44A5 Gene

Proteomics data for SLC44A5 Gene at MOPED

Post-translational modifications for SLC44A5 Gene

  • Glycosylation at Asn88, Asn190, and Asn314
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC44A5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC44A5 Gene

Domains for SLC44A5 Gene

Gene Families for SLC44A5 Gene

Protein Domains for SLC44A5 Gene


Suggested Antigen Peptide Sequences for SLC44A5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8NCS7
  • Belongs to the CTL (choline transporter-like) family.
genes like me logo Genes that share domains with SLC44A5: view

Function for SLC44A5 Gene

Phenotypes for SLC44A5 Gene

genes like me logo Genes that share phenotypes with SLC44A5: view

Animal Model Products

CRISPR Products

miRNA for SLC44A5 Gene

miRTarBase miRNAs that target SLC44A5

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC44A5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC44A5 Gene

Localization for SLC44A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC44A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC44A5 Gene COMPARTMENTS Subcellular localization image for SLC44A5 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC44A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC44A5: view

Pathways for SLC44A5 Gene

genes like me logo Genes that share pathways with SLC44A5: view

Interacting Proteins for SLC44A5 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000359892 for SLC44A5 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC44A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046474 glycerophospholipid biosynthetic process TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC44A5: view

Transcripts for SLC44A5 Gene

Unigene Clusters for SLC44A5 Gene

Solute carrier family 44, member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC44A5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC44A5 Gene

No ASD Table

Relevant External Links for SLC44A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC44A5 Gene

mRNA expression in normal human tissues for SLC44A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC44A5 Gene

This gene is overexpressed in Esophagus - Mucosa (4.6) and Skin - Sun Exposed (Lower leg) (4.5).

SOURCE GeneReport for Unigene cluster for SLC44A5 Gene Hs.654821

genes like me logo Genes that share expressions with SLC44A5: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for SLC44A5 Gene

Orthologs for SLC44A5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC44A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC44A5 35
  • 83.85 (n)
  • 74.3 (a)
SLC44A5 36
  • 76 (a)
(Canis familiaris)
Mammalia SLC44A5 35
  • 85.03 (n)
  • 75.73 (a)
SLC44A5 36
  • 80 (a)
(Mus musculus)
Mammalia Slc44a5 35
  • 77.18 (n)
  • 70 (a)
Slc44a5 16
Slc44a5 36
  • 70 (a)
(Pan troglodytes)
Mammalia SLC44A5 35
  • 97.29 (n)
  • 96.71 (a)
SLC44A5 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Slc44a5 35
  • 76.01 (n)
  • 70.15 (a)
(Monodelphis domestica)
Mammalia SLC44A5 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
-- 36
  • 66 (a)
(Gallus gallus)
Aves SLC44A5 35
  • 71.52 (n)
  • 66.71 (a)
SLC44A5 36
  • 66 (a)
(Anolis carolinensis)
Reptilia SLC44A5 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc44a5 35
  • 68.18 (n)
  • 66.01 (a)
(Danio rerio)
Actinopterygii slc44a5b 35
  • 65.15 (n)
  • 62.78 (a)
slc44a5a 36
  • 61 (a)
slc44a5b 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11880 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea chtl-1 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PNS1 36
  • 20 (a)
PNS1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for SLC44A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC44A5 Gene

Gene Tree for SLC44A5 (if available)
Gene Tree for SLC44A5 (if available)

Paralogs for SLC44A5 Gene

Paralogs for SLC44A5 Gene

Selected SIMAP similar genes for SLC44A5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC44A5: view

Variants for SLC44A5 Gene

Sequence variations from dbSNP and Humsavar for SLC44A5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs106252 -- 75,523,602(-) gctca(C/T)gcctg intron-variant
rs169830 -- 75,606,984(+) gagtc(A/T)tccag intron-variant
rs169831 -- 75,538,239(+) CATTT(A/G)TTACA intron-variant
rs169832 -- 75,575,263(+) TATTT(C/G)TAAGT intron-variant
rs172449 -- 75,554,894(+) acacc(A/C)aaaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC44A5 Gene

Variant ID Type Subtype PubMed ID
nsv871743 CNV Gain 21882294
esv1169956 CNV Insertion 17803354
esv1320217 CNV Insertion 17803354
esv2749974 CNV Deletion 23290073
nsv1455 CNV Loss 18451855
nsv519329 CNV Gain 19592680
nsv508304 CNV Loss 20534489
nsv435643 CNV Deletion 17901297
esv1008813 CNV Deletion 20482838
nsv498673 CNV Loss 21111241
esv1527298 CNV Deletion 17803354
dgv60e1 CNV Complex 17122850
nsv830270 CNV Loss 17160897
esv2613586 CNV Deletion 19546169
esv1954052 CNV Deletion 18987734
esv4835 CNV Deletion 18987735
esv2749985 CNV Deletion 23290073
esv1010081 CNV Deletion 20482838
nsv159607 CNV Loss 16902084
esv7181 CNV Loss 19470904
esv1700928 CNV Deletion 17803354
esv994396 CNV Deletion 20482838
esv269022 CNV Insertion 20981092

Relevant External Links for SLC44A5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC44A5 Gene

Disorders for SLC44A5 Gene

Relevant External Links for SLC44A5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SLC44A5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SLC44A5 Gene

Publications for SLC44A5 Gene

  1. Molecular characterization of the family of choline transporter-like proteins and their splice variants. (PMID: 15715662) Traiffort E. … Meunier F.-M. (J. Neurochem. 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3 48

Products for SLC44A5 Gene

Sources for SLC44A5 Gene

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