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Aliases for SLC44A3 Gene

Aliases for SLC44A3 Gene

  • Solute Carrier Family 44 Member 3 2 3 4 5
  • Solute Carrier Family 44, Member 3 2 3
  • CTL3 3 4
  • Solute Carrier Family, Member 3 2

External Ids for SLC44A3 Gene

Previous GeneCards Identifiers for SLC44A3 Gene

  • GC01P094998
  • GC01P095286
  • GC01P093407

Summaries for SLC44A3 Gene

GeneCards Summary for SLC44A3 Gene

SLC44A3 (Solute Carrier Family 44 Member 3) is a Protein Coding gene. Among its related pathways are Glycerophospholipid biosynthesis and Metabolism. An important paralog of this gene is SLC44A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC44A3 Gene

Genomics for SLC44A3 Gene

Regulatory Elements for SLC44A3 Gene

Enhancers for SLC44A3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC44A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC44A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC44A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC44A3 Gene

94,820,342 bp from pter
94,895,247 bp from pter
74,906 bases
Plus strand

Genomic View for SLC44A3 Gene

Genes around SLC44A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC44A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC44A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC44A3 Gene

Proteins for SLC44A3 Gene

  • Protein details for SLC44A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Choline transporter-like protein 3
    Protein Accession:
    Secondary Accessions:
    • B4DVY4
    • B4E1M4
    • B7ZA08
    • E9PJH2
    • E9PJY8
    • Q6UWT1
    • Q7Z6C5
    • Q9BWY7

    Protein attributes for SLC44A3 Gene

    653 amino acids
    Molecular mass:
    73783 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH33858.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ89022.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC44A3 Gene

neXtProt entry for SLC44A3 Gene

Proteomics data for SLC44A3 Gene at MOPED

Post-translational modifications for SLC44A3 Gene

  • Glycosylation at Asn 136, Asn 151, Asn 412, Asn 503, and Asn 521
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC44A3 Gene

Domains & Families for SLC44A3 Gene

Gene Families for SLC44A3 Gene

Protein Domains for SLC44A3 Gene


Suggested Antigen Peptide Sequences for SLC44A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CTL (choline transporter-like) family.
  • Belongs to the CTL (choline transporter-like) family.
genes like me logo Genes that share domains with SLC44A3: view

Function for SLC44A3 Gene

Phenotypes for SLC44A3 Gene

genes like me logo Genes that share phenotypes with SLC44A3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC44A3

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC44A3 Gene

Localization for SLC44A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC44A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC44A3 Gene COMPARTMENTS Subcellular localization image for SLC44A3 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for SLC44A3 Gene

Pathways & Interactions for SLC44A3 Gene

genes like me logo Genes that share pathways with SLC44A3: view

Pathways by source for SLC44A3 Gene

Gene Ontology (GO) - Biological Process for SLC44A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0015871 choline transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC44A3: view

No data available for SIGNOR curated interactions for SLC44A3 Gene

Drugs & Compounds for SLC44A3 Gene

(1) Drugs for SLC44A3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Choline Approved Nutra Transporter, substrate 139
genes like me logo Genes that share compounds with SLC44A3: view

Transcripts for SLC44A3 Gene

Unigene Clusters for SLC44A3 Gene

Solute carrier family 44, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC44A3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
SP1: - -
SP2: - -

Relevant External Links for SLC44A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC44A3 Gene

mRNA expression in normal human tissues for SLC44A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC44A3 Gene

This gene is overexpressed in Colon - Transverse (x4.7) and Pancreas (x4.0).

Protein differential expression in normal tissues from HIPED for SLC44A3 Gene

This gene is overexpressed in Retina (42.5) and Pancreas (26.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC44A3 Gene

SOURCE GeneReport for Unigene cluster for SLC44A3 Gene Hs.483423

genes like me logo Genes that share expression patterns with SLC44A3: view

Protein tissue co-expression partners for SLC44A3 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC44A3 Gene

Orthologs for SLC44A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC44A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC44A3 35
  • 88.08 (n)
  • 87.21 (a)
SLC44A3 36
  • 87 (a)
(Canis familiaris)
Mammalia SLC44A3 35
  • 86.64 (n)
  • 83.56 (a)
SLC44A3 36
  • 67 (a)
(Mus musculus)
Mammalia Slc44a3 35
  • 82.39 (n)
  • 81.26 (a)
Slc44a3 16
Slc44a3 36
  • 81 (a)
(Pan troglodytes)
Mammalia SLC44A3 35
  • 99.74 (n)
  • 99.69 (a)
SLC44A3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Slc44a3 35
  • 81.57 (n)
  • 80.46 (a)
(Monodelphis domestica)
Mammalia SLC44A3 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
-- 36
  • 74 (a)
(Gallus gallus)
Aves SLC44A3 35
  • 69.61 (n)
  • 65.74 (a)
SLC44A3 36
  • 64 (a)
(Anolis carolinensis)
Reptilia SLC44A3 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1311 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PNS1 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1906 36
  • 39 (a)
Species with no ortholog for SLC44A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC44A3 Gene

Gene Tree for SLC44A3 (if available)
Gene Tree for SLC44A3 (if available)

Paralogs for SLC44A3 Gene

Paralogs for SLC44A3 Gene

(3) SIMAP similar genes for SLC44A3 Gene using alignment to 5 proteins: Pseudogenes for SLC44A3 Gene

genes like me logo Genes that share paralogs with SLC44A3: view

Variants for SLC44A3 Gene

Sequence variations from dbSNP and Humsavar for SLC44A3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs859098 - 94,864,816(+) GAACC(A/G)TTGTG nc-transcript-variant, reference, missense
VAR_064752 -
rs696620 -- 94,851,908(-) GATTG(C/T)TATAG intron-variant
rs696621 -- 94,848,996(-) CTGAC(C/T)TCACT intron-variant
rs698953 -- 94,877,496(-) TCTCC(A/G)CCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC44A3 Gene

Variant ID Type Subtype PubMed ID
nsv506949 CNV Insertion 20534489
esv267890 CNV Insertion 20981092
esv272153 CNV Insertion 20981092

Variation tolerance for SLC44A3 Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC44A3 Gene

Disorders for SLC44A3 Gene

Relevant External Links for SLC44A3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC44A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC44A3 Gene

Publications for SLC44A3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Molecular characterization of the family of choline transporter-like proteins and their splice variants. (PMID: 15715662) Traiffort E. … Meunier F.-M. (J. Neurochem. 2005) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PMID: 23934736) Yu B. … Boerwinkle E. (Genet. Epidemiol. 2013) 3
  5. A genome-wide association search for type 2 diabetes genes in African Americans. (PMID: 22238593) Palmer N.D. … Sladek R. (PLoS ONE 2012) 3

Products for SLC44A3 Gene

Sources for SLC44A3 Gene