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Aliases for SLC44A3 Gene

Aliases for SLC44A3 Gene

  • Solute Carrier Family 44, Member 3 2 3
  • CTL3 3 4
  • Choline Transporter-Like Protein 3 3
  • Solute Carrier Family 44 Member 3 4
  • Solute Carrier Family, Member 3 2

External Ids for SLC44A3 Gene

Previous GeneCards Identifiers for SLC44A3 Gene

  • GC01P094998
  • GC01P095286
  • GC01P093407

Summaries for SLC44A3 Gene

GeneCards Summary for SLC44A3 Gene

SLC44A3 (Solute Carrier Family 44, Member 3) is a Protein Coding gene. Diseases associated with SLC44A3 include cystinuria. Among its related pathways are Metabolism and Metabolism. An important paralog of this gene is SLC44A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC44A3 Gene

Genomics for SLC44A3 Gene

Regulatory Elements for SLC44A3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC44A3 Gene

94,820,342 bp from pter
94,895,247 bp from pter
74,906 bases
Plus strand

Genomic View for SLC44A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC44A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC44A3 Gene

Proteins for SLC44A3 Gene

  • Protein details for SLC44A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Choline transporter-like protein 3
    Protein Accession:
    Secondary Accessions:
    • B4DVY4
    • B4E1M4
    • B7ZA08
    • E9PJH2
    • E9PJY8
    • Q6UWT1
    • Q7Z6C5
    • Q9BWY7

    Protein attributes for SLC44A3 Gene

    653 amino acids
    Molecular mass:
    73783 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH33858.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ89022.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC44A3 Gene

neXtProt entry for SLC44A3 Gene

Proteomics data for SLC44A3 Gene at MOPED

Post-translational modifications for SLC44A3 Gene

  • Glycosylation at Asn136, Asn151, Asn412, Asn503, and Asn521
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC44A3 Gene

Domains for SLC44A3 Gene

Gene Families for SLC44A3 Gene

Protein Domains for SLC44A3 Gene


Suggested Antigen Peptide Sequences for SLC44A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8N4M1
  • Belongs to the CTL (choline transporter-like) family.
genes like me logo Genes that share domains with SLC44A3: view

Function for SLC44A3 Gene

Gene Ontology (GO) - Molecular Function for SLC44A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SLC44A3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC44A3 Gene

Localization for SLC44A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC44A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC44A3 Gene COMPARTMENTS Subcellular localization image for SLC44A3 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC44A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC44A3: view

Pathways for SLC44A3 Gene

genes like me logo Genes that share pathways with SLC44A3: view

Gene Ontology (GO) - Biological Process for SLC44A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046474 glycerophospholipid biosynthetic process TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC44A3: view

Compounds for SLC44A3 Gene

(1) HMDB Compounds for SLC44A3 Gene

Compound Synonyms Cas Number PubMed IDs
  • (2-Hydroxyethyl)trimethyl ammonium

(1) Drugbank Compounds for SLC44A3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • Bilineurine
62-49-7 transporter substrate
genes like me logo Genes that share compounds with SLC44A3: view

Transcripts for SLC44A3 Gene

Unigene Clusters for SLC44A3 Gene

Solute carrier family 44, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC44A3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC44A3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC44A3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
SP1: - -
SP2: - -

Relevant External Links for SLC44A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC44A3 Gene

mRNA expression in normal human tissues for SLC44A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC44A3 Gene

This gene is overexpressed in Colon - Transverse (4.7) and Pancreas (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC44A3 Gene

SOURCE GeneReport for Unigene cluster for SLC44A3 Gene Hs.483423

genes like me logo Genes that share expressions with SLC44A3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC44A3 Gene

Orthologs for SLC44A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC44A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC44A3 35
  • 99.74 (n)
  • 99.69 (a)
SLC44A3 36
  • 100 (a)
(Bos Taurus)
Mammalia SLC44A3 35
  • 88.08 (n)
  • 87.21 (a)
SLC44A3 36
  • 87 (a)
(Canis familiaris)
Mammalia SLC44A3 35
  • 86.64 (n)
  • 83.56 (a)
SLC44A3 36
  • 67 (a)
(Mus musculus)
Mammalia Slc44a3 35
  • 82.39 (n)
  • 81.26 (a)
Slc44a3 16
Slc44a3 36
  • 81 (a)
(Monodelphis domestica)
Mammalia SLC44A3 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
-- 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Slc44a3 35
  • 81.57 (n)
  • 80.46 (a)
(Gallus gallus)
Aves SLC44A3 35
  • 69.61 (n)
  • 65.74 (a)
SLC44A3 36
  • 64 (a)
(Anolis carolinensis)
Reptilia SLC44A3 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1311 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PNS1 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1906 36
  • 39 (a)
Species with no ortholog for SLC44A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC44A3 Gene

Gene Tree for SLC44A3 (if available)
Gene Tree for SLC44A3 (if available)

Paralogs for SLC44A3 Gene

Paralogs for SLC44A3 Gene

Selected SIMAP similar genes for SLC44A3 Gene using alignment to 5 proteins: Pseudogenes for SLC44A3 Gene

genes like me logo Genes that share paralogs with SLC44A3: view

Variants for SLC44A3 Gene

Sequence variations from dbSNP and Humsavar for SLC44A3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs696620 -- 94,851,908(-) GATTG(C/T)TATAG intron-variant
rs696621 -- 94,848,996(-) CTGAC(C/T)TCACT intron-variant
rs698953 -- 94,877,496(-) TCTCC(A/G)CCTTG intron-variant
rs698954 -- 94,876,816(-) ATTAA(A/G)TTTTC intron-variant
rs698955 -- 94,871,391(-) AGAAT(A/G)GCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC44A3 Gene

Variant ID Type Subtype PubMed ID
nsv506949 CNV Insertion 20534489
esv267890 CNV Insertion 20981092
esv272153 CNV Insertion 20981092

Relevant External Links for SLC44A3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC44A3 Gene

Disorders for SLC44A3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC44A3 Gene including...

Search for SLC44A3 Gene in MalaCards »

Relevant External Links for SLC44A3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC44A3: view

No data available for UniProtKB/Swiss-Prot for SLC44A3 Gene

Publications for SLC44A3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Molecular characterization of the family of choline transporter-like proteins and their splice variants. (PMID: 15715662) Traiffort E. … Meunier F.-M. (J. Neurochem. 2005) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins. (PMID: 10677542) O'Regan S. … Meunier F.-M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4

Products for SLC44A3 Gene

Sources for SLC44A3 Gene

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