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Aliases for SLC44A3 Gene

Aliases for SLC44A3 Gene

  • Solute Carrier Family 44 Member 3 2 3 4 5
  • CTL3 3 4
  • Solute Carrier Family 44, Member 3 2
  • Choline Transporter-Like Protein 3 3
  • Solute Carrier Family, Member 3 2

External Ids for SLC44A3 Gene

Previous GeneCards Identifiers for SLC44A3 Gene

  • GC01P094998
  • GC01P095286
  • GC01P093407

Summaries for SLC44A3 Gene

GeneCards Summary for SLC44A3 Gene

SLC44A3 (Solute Carrier Family 44 Member 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Synthesis of PC. An important paralog of this gene is SLC44A1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC44A3 Gene

Genomics for SLC44A3 Gene

Regulatory Elements for SLC44A3 Gene

Enhancers for SLC44A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G094792 1.5 FANTOM5 Ensembl ENCODE 29.5 -27.3 -27287 2.1 FOXA2 ATF1 TCF12 FOS RELB ETV6 IKZF2 CEBPB ZEB2 TBX21 SLC44A3 F3 SLC44A3-AS1 GC01M094794 MIR378G
GH01G094753 1.7 FANTOM5 Ensembl ENCODE dbSUPER 24.2 -65.4 -65360 3.7 ATF1 SIN3A ZNF48 TCF12 FOS REST MEF2D MIER3 MAFF NR2C1 SLC44A3 F3 SLC44A3-AS1 MIR378G GC01M094794
GH01G094782 1.1 Ensembl ENCODE 27.6 -36.7 -36655 2.3 PKNOX1 ZNF76 KLF17 FEZF1 RFX5 TCF12 TSHZ1 ZEB2 ZFP69B GLIS1 SLC44A3 SLC44A3-AS1 F3 GC01M094794 MIR378G
GH01G094805 1.2 Ensembl ENCODE 23.1 -12.6 -12631 3.8 FOXA2 ATF1 WRNIP1 ARID4B FEZF1 ZNF2 TCF12 GATA2 ZNF143 FOS SLC44A3 F3 ABCD3 GC01M094811 GC01M094794
GH01G094738 1.1 Ensembl ENCODE dbSUPER 22.6 -80.7 -80656 1.6 BHLHE40 ELF1 NR3C1 ZNF664 JUND GATA2 FOS NR2C2 NFE2L2 SLC44A3 F3 SLC44A3-AS1 GC01M094659 GC01P094696
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC44A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC44A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000010197 158 1401 ELF3 FOXA2 ARID4B KLF17 DMAP1 RAD21 ZNF48 ZEB1 RARA GLIS2

Genomic Location for SLC44A3 Gene

Chromosome:
1
Start:
94,820,342 bp from pter
End:
94,895,247 bp from pter
Size:
74,906 bases
Orientation:
Plus strand

Genomic View for SLC44A3 Gene

Genes around SLC44A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC44A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC44A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC44A3 Gene

Proteins for SLC44A3 Gene

  • Protein details for SLC44A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4M1-CTL3_HUMAN
    Recommended name:
    Choline transporter-like protein 3
    Protein Accession:
    Q8N4M1
    Secondary Accessions:
    • B4DVY4
    • B4E1M4
    • B7ZA08
    • E9PJH2
    • E9PJY8
    • Q6UWT1
    • Q7Z6C5
    • Q9BWY7

    Protein attributes for SLC44A3 Gene

    Size:
    653 amino acids
    Molecular mass:
    73783 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH33858.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ89022.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC44A3 Gene

neXtProt entry for SLC44A3 Gene

Post-translational modifications for SLC44A3 Gene

  • Glycosylation at isoforms=2, 3136, Asn151, Asn412, Asn503, and Asn521
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC44A3 Gene

Domains & Families for SLC44A3 Gene

Gene Families for SLC44A3 Gene

Protein Domains for SLC44A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC44A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4M1

UniProtKB/Swiss-Prot:

CTL3_HUMAN :
  • Belongs to the CTL (choline transporter-like) family.
Family:
  • Belongs to the CTL (choline transporter-like) family.
genes like me logo Genes that share domains with SLC44A3: view

Function for SLC44A3 Gene

Gene Ontology (GO) - Molecular Function for SLC44A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0015220 choline transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC44A3: view

Phenotypes for SLC44A3 Gene

genes like me logo Genes that share phenotypes with SLC44A3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC44A3

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC44A3 Gene

Localization for SLC44A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC44A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC44A3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC44A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC44A3: view

Pathways & Interactions for SLC44A3 Gene

genes like me logo Genes that share pathways with SLC44A3: view

Pathways by source for SLC44A3 Gene

Interacting Proteins for SLC44A3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000271227%0d%0a9606.ENSP00000355173%0d%0a
Selected Interacting proteins: ENSP00000271227 Q8N4M1-CTL3_HUMAN for SLC44A3 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for SLC44A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0015871 choline transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC44A3: view

No data available for SIGNOR curated interactions for SLC44A3 Gene

Drugs & Compounds for SLC44A3 Gene

(1) Drugs for SLC44A3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Choline Approved Nutra Transporter, substrate 154
genes like me logo Genes that share compounds with SLC44A3: view

Transcripts for SLC44A3 Gene

Unigene Clusters for SLC44A3 Gene

Solute carrier family 44, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC44A3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for SLC44A3 Gene

GeneLoc Exon Structure for
SLC44A3
ECgene alternative splicing isoforms for
SLC44A3

Expression for SLC44A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC44A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC44A3 Gene

This gene is overexpressed in Colon - Transverse (x4.7) and Pancreas (x4.0).

Protein differential expression in normal tissues from HIPED for SLC44A3 Gene

This gene is overexpressed in Retina (42.5) and Pancreas (26.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC44A3 Gene



Protein tissue co-expression partners for SLC44A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC44A3 Gene:

SLC44A3

SOURCE GeneReport for Unigene cluster for SLC44A3 Gene:

Hs.483423

Evidence on tissue expression from TISSUES for SLC44A3 Gene

  • Intestine(4.5)
  • Stomach(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SLC44A3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC44A3 Gene

Orthologs for SLC44A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC44A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC44A3 34 35
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia SLC44A3 34 35
  • 88.08 (n)
dog
(Canis familiaris)
Mammalia SLC44A3 34 35
  • 86.64 (n)
mouse
(Mus musculus)
Mammalia Slc44a3 34 16 35
  • 82.39 (n)
rat
(Rattus norvegicus)
Mammalia Slc44a3 34
  • 81.57 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC44A3 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC44A3 34 35
  • 69.61 (n)
lizard
(Anolis carolinensis)
Reptilia SLC44A3 35
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1311 35
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PNS1 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1906 35
  • 39 (a)
OneToMany
Species where no ortholog for SLC44A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC44A3 Gene

ENSEMBL:
Gene Tree for SLC44A3 (if available)
TreeFam:
Gene Tree for SLC44A3 (if available)

Paralogs for SLC44A3 Gene

Paralogs for SLC44A3 Gene

(3) SIMAP similar genes for SLC44A3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SLC44A3 Gene

genes like me logo Genes that share paralogs with SLC44A3: view

Variants for SLC44A3 Gene

Sequence variations from dbSNP and Humsavar for SLC44A3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000000264 -- 94,873,859(+) GATGT(A/T)AAGTT intron-variant
rs1000039889 -- 94,849,135(+) GGAGG(C/T)TATTC intron-variant
rs1000091701 -- 94,833,923(+) ATAAG(A/G)AGCTG intron-variant
rs1000128873 -- 94,886,085(+) CCTAG(A/C)CCCTG intron-variant
rs1000145508 -- 94,888,286(+) GAATT(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC44A3 Gene

Variant ID Type Subtype PubMed ID
esv3307879 CNV mobile element insertion 20981092
esv3341362 CNV insertion 20981092
esv3357039 CNV insertion 20981092
esv3382096 CNV insertion 20981092
nsv506949 OTHER sequence alteration 20534489

Variation tolerance for SLC44A3 Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC44A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC44A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC44A3 Gene

Disorders for SLC44A3 Gene

Relevant External Links for SLC44A3

Genetic Association Database (GAD)
SLC44A3
Human Genome Epidemiology (HuGE) Navigator
SLC44A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC44A3

No disorders were found for SLC44A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC44A3 Gene

Publications for SLC44A3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Molecular characterization of the family of choline transporter-like proteins and their splice variants. (PMID: 15715662) Traiffort E. … Meunier F.-M. (J. Neurochem. 2005) 2 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SLC44A3 Gene

Sources for SLC44A3 Gene

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