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SLC44A2 Gene

protein-coding   GIFtS: 58
GCID: GC19P010713

Solute Carrier Family 44 (Choline Transporter), Member 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 44 (Choline Transporter), Member 21 2
CTL22 3 5
PP12922
Choline Transporter-Like Protein 22
Solute Carrier Family 44, Member 22
Solute Carrier Family 44 Member 23

External Ids:    HGNC: 172921   Entrez Gene: 571532   Ensembl: ENSG000001293537   OMIM: 6061065   UniProtKB: Q8IWA53   

Export aliases for SLC44A2 gene to outside databases

Previous GC identifers: GC19P010575 GC19P010290


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC44A2 Gene:
SLC44A2 (solute carrier family 44 (choline transporter), member 2) is a protein-coding gene. GO annotations related to this gene include choline transmembrane transporter activity and signal transducer activity. An important paralog of this gene is SLC44A1.

UniProtKB/Swiss-Prot: CTL2_HUMAN, Q8IWA5
Function: Isoform 1, but not isoform 3, exhibits some choline transporter activity

Gene Wiki entry for SLC44A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC44A2 gene promoter:
         USF1   Sp1   NF-YA   Ik-2   CBF-A   CBF-B   USF-1   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC44A2 promoter sequence
   Search Chromatin IP Primers for SLC44A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC44A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.1

SLC44A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC44A2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010713:  view genomic region     (about GC identifiers)

Start:
10,713,121 bp from pter      End:
10,755,235 bp from pter
Size:
42,115 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CTL2_HUMAN, Q8IWA5 (See protein sequence)
Recommended Name: Choline transporter-like protein 2  
Size: 706 amino acids; 80124 Da
Subunit: Interacts with COCH
Sequence caution: Sequence=BAC11662.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RBB1 B3KNH3 B4DFJ0 F2Q9D7 Q658V1 Q658Z2 Q6PJV7 Q8N2F0 Q9NY68
Alternative promoter usage, Alternative splicing: 3 isoforms:  Q8IWA5-1   Q8IWA5-2   Q8IWA5-3   (Produced by alternative promoter usage)

Explore the universe of human proteins at neXtProt for SLC44A2: NX_Q8IWA5

Explore proteomics data for SLC44A2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn187, Asn200, Asn417
  • Modification sites at PhosphoSitePlus

  • See SLC44A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138528.1  NP_065161.3  

    ENSEMBL proteins: 
     ENSP00000468691   ENSP00000385135   ENSP00000336888   ENSP00000465547   ENSP00000467552  
     ENSP00000466664   ENSP00000466612   ENSP00000468070   ENSP00000466575   ENSP00000468812  
    Reactome Protein details: Q8IWA5

    SLC44A2 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for SLC44A2 (3 products) 

     
    antibodies-online peptides for SLC44A2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Choline transporter-like 2
    SLC44 family of choline transporters

    1 InterPro protein domain:
     IPR007603 Choline_transptr-like

    Graphical View of Domain Structure for InterPro Entry Q8IWA5

    ProtoNet protein and cluster: Q8IWA5

    UniProtKB/Swiss-Prot: CTL2_HUMAN, Q8IWA5
    Similarity: Belongs to the CTL (choline transporter-like) family


    Find genes that share domains with SLC44A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTL2_HUMAN, Q8IWA5
    Function: Isoform 1, but not isoform 3, exhibits some choline transporter activity

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0015220choline transmembrane transporter activity TAS10677542
         
    Find genes that share ontologies with SLC44A2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC44A2

    miRNA
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    miRTarBase miRNAs that target SLC44A2:
    hsa-mir-124-3p (MIRT023182)

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    hsa-miR-140-5p hsa-miR-3673 hsa-miR-642a hsa-miR-4311 hsa-miR-520d-5p hsa-miR-1271 hsa-miR-449a hsa-miR-124
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTL2_HUMAN, Q8IWA5: Membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane TAS10677542
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SLC44A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC44A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Synthesis of PC0.00
    Phospholipid metabolism0.64
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37


    Find genes that share SuperPaths with SLC44A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for SLC44A2
        Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Synthesis of PC


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC44A2
    Interactions:

        Search GeneGlobe Interaction Network for SLC44A2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for SLC44A2 (Q8IWA53 ENSP000003368884) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBL1P287493I2D: score=1 
    ACHEENSP000003032114STRING: ENSP00000303211
    CHATENSP000003371034STRING: ENSP00000337103
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006656phosphatidylcholine biosynthetic process TAS--
    GO:0007165signal transduction IMP12761501
    GO:0015871choline transport TAS10677542
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IMP12761501

    Find genes that share ontologies with SLC44A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC44A2 (CTL2)

    1 HMDB Compound for SLC44A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Choline(2-Hydroxyethyl)trimethyl ammonium (see all 19)62-49-7--

    1 DrugBank Compound for SLC44A2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CholineBilineurine (see all 7)62-49-7transportersubstrate17139284 17016423

    1 Novoseek inferred chemical compound relationship for SLC44A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choline 67.2 18 20410607 (4), 20040764 (3), 14973250 (2), 19319905 (1) (see all 7)



    Find genes that share compounds with SLC44A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC44A2 gene (2 alternative transcripts): 
    NM_001145056.1  NM_020428.3  

    Unigene Cluster for SLC44A2:

    Solute carrier family 44, member 2
    Hs.534560  [show with all ESTs]
    Unigene Representative Sequence: NM_020428
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000590382 ENST00000588465 ENST00000407327(uc002mpe.4 uc002mpg.1 uc002mph.3 uc002mpi.3)
    ENST00000335757(uc002mpf.3) ENST00000590857 ENST00000588688 ENST00000586078
    ENST00000592293 ENST00000588409 ENST00000588393 ENST00000589561 ENST00000588214
    ENST00000591194 ENST00000586549 ENST00000590475
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    hsa-miR-140-5p hsa-miR-3673 hsa-miR-642a hsa-miR-4311 hsa-miR-520d-5p hsa-miR-1271 hsa-miR-449a hsa-miR-124
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      QuantiFast Probe-based Assays in human, mouse, rat SLC44A2

    Additional mRNA sequence: 

    AF070636.1 AF258549.1 AK027519.1 AK075512.1 AK126550.1 AK294118.1 AK309801.1 AK314582.1 
    AL832517.1 AL832978.1 BC010617.2 BC020511.1 BC040556.1 BC042692.1 FN668568.1 

    Selected DOTS entries (see all 30):

    DT.102833692  DT.95355206  DT.95355268  DT.441730  DT.92459939  DT.100799933  DT.100833552  DT.100821485 
    DT.100821488  DT.101985238  DT.75125134  DT.97768532  DT.121484197  DT.95355285  DT.100821481  DT.121484204 
    DT.91718975  DT.121484147  DT.121484169  DT.121484144  DT.97817352  DT.100821482  DT.121484209  DT.121484217 

    Selected AceView cDNA sequences (see all 656):

    CF454292 BE280532 BG291478 BX089770 CF265145 BM463400 AL555711 BE269190 
    Z40821 BM718029 BE294075 CA396907 BM763670 AF070636 BU186009 BM706925 
    AI140661 AA368328 BQ717663 BG741388 BF325888 AW408627 AA455518 R84842 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC44A2 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b · 16c ·
    SP1:                                                                                                                          -     -           -               
    SP2:        -     -                                                                                                           -     -           -               
    SP3:                                                                                                                          -     -           -               
    SP4:                                                                                                                          -     -           -               
    SP5:                                                                                                                                                            

    ExUns: 16d · 16e ^ 17a · 17b · 17c ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b
    SP1:                                                                          -     -               
    SP2:                                                                          -     -               
    SP3:        -     -                                                           -     -               
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for SLC44A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC44A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTAAAGGG
    SLC44A2 Expression
    About this image


    SLC44A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mandibular Condyle
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Thyroid (Endocrine System)
    SLC44A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC44A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534560

    UniProtKB/Swiss-Prot: CTL2_HUMAN, Q8IWA5
    Tissue specificity: Present in supporting cells of the inner ear (at protein level). Only isoform 3 is expressed
    in inner ear vestibular tissue

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC44A2 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc44a21 , 5 solute carrier family 44, member 21, 5 84.78(n)1
    90.47(a)1
      9 (7.77 cM)5
    686821  NM_152808.31  NP_690021.11 
     213378285 
    chicken
    (Gallus gallus)
    Aves SLC44A26
    solute carrier family 44 (choline transporter), me...
    72(a)
    1 ↔ 1
    AADN03023623.1(21-5060)
    lizard
    (Anolis carolinensis)
    Reptilia SLC44A26
    solute carrier family 44 (choline transporter), me...
    80(a)
    1 ↔ 1
    2(80492630-80563954)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ042568.12   -- 78.79(n)    BJ042568.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb392 sbcb39 75.6(n)   321056  BC054915.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG118806
    --
    31(a)
    1 → many
    3R(24949104-24953972)
    worm
    (Caenorhabditis elegans)
    Secernentea chtl-16
    Protein CHTL-1, isoform a (chtl-1) mRNA, complete ...
    35(a)
    1 → many
    X(5355634-5364322) WBGene00018037
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PNS16
    Protein of unknown function; has similarity to Tor...
    19(a)
    1 → many
    XV(636939-638558) YOR161C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G153801 AT3G15380 42.49(n)
    27(a)
      820777  NM_112406.4  NP_566511.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g06816001 Os04g0681600 43.59(n)
    28.83(a)
      4337433  NM_001060826.1  NP_001054291.1 


    ENSEMBL Gene Tree for SLC44A2 (if available)
    TreeFam Gene Tree for SLC44A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC44A2 gene
    SLC44A12  SLC44A52  SLC44A32  SLC44A42  
    4 SIMAP similar genes for SLC44A2 using alignment to 8 protein entries:     CTL2_HUMAN (see all proteins):
    SLC44A5    SLC44A3    SLC44A4    SLC44A1

    Find genes that share paralogs with SLC44A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC44A2 (see all 1037)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs556520291,2
    C--10296215(+) TTATT-/A/AT  
            
    TTTTT
    1 -- int11NA 2
    rs1388752411,2
    --10711164(+) CACCAA/GTGATC 1 -- us2k10--------
    rs1494092211,2
    C--10711393(+) CACCAA/GCAGTG 1 -- us2k10--------
    rs1871377031,2
    --10711436(+) CAACAC/TTTGGT 1 -- us2k10--------
    rs757760961,2
    F--10711473(+) TTCAGG/CTGGGT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs2006156031,2
    --10711542(+) TCTTT-/TTTC  
            
    TTTCT
    1 -- us2k10--------
    rs559011281,2
    C--10711559(+) TTTTT-/T/TT  
            
    GAGAC
    1 -- us2k10--------
    rs1511346951,2
    C--10711559(+) TTTTT-/TTGAGAC 1 -- us2k10--------
    rs2016578211,2
    --10711561(+) TCTTT-/CTTTTT 1 -- us2k10--------
    rs343182611,2
    C--10711733(+) GCAACT/CTCCAC 1 -- us2k11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for SLC44A2 (10713121 - 10755235 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLC44A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833744CNV Loss17160897
    nsv911047CNV Loss21882294
    nsv911046CNV Loss21882294
    nsv911042CNV Loss21882294
    nsv911048CNV Loss21882294
    nsv833745CNV Loss17160897

    Human Gene Mutation Database (HGMD): SLC44A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC44A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC44A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606106    OMIM disorders: --


    Find genes that share disorders with SLC44A2           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SLC44A2 (1 document)

    Export disorders for SLC44A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC44A2 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with SLC44A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins. (PubMed id 10677542)1, 2, 3 O'Regan S.... Meunier F.-M. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    2. Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss. (PubMed id 14973250)1, 2, 9 Nair T.S.... Carey T.E. (J. Neurosci. 2004)
    3. Cochlin isoforms and their interaction with CTL2 (SLC44A2) in the inner ear. (PubMed id 17926100)1, 2, 9 Kommareddi P.K.... Carey T.E. (J. Assoc. Res. Otolaryngol. 2007)
    4. Isoforms, expression, glycosylation, and tissue distribution of CTL2/SLC44A2. (PubMed id 20665236)1, 2 Kommareddi P.K.... Carey T.E. (Protein J. 2010)
    5. Molecular characterization of the family of choline transporter-like proteins and their splice variants. (PubMed id 15715662)1, 3 Traiffort E.... Meunier F.-M. (J. Neurochem. 2005)
    6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake. (PubMed id 20410607)1, 9 Nakamura T....Tamai I. (amp 2010)
    10. The neutrophil alloantigen HNA-3a (5b) is located on choline transporter-like protein 2 and appears to be encoded by an R&gt;Q154 amino acid substitution. (PubMed id 20040764)1, 9 Curtis B.R....Aster R.H. (Blood 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57153 HGNC: 17292 AceView: CTL2 Ensembl:ENSG00000129353 euGenes: HUgn57153
    ECgene: SLC44A2 H-InvDB: SLC44A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC44A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC44A2 gene:
    Search GeneIP for patents involving SLC44A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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