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Aliases for SLC44A1 Gene

Aliases for SLC44A1 Gene

  • Solute Carrier Family 44 (Choline Transporter), Member 1 2 3
  • CDW92 3 4 6
  • CTL1 3 4 6
  • CDW92 Antigen 2 3
  • CD92 3 4
  • Choline Transporter-Like Protein 1 3
  • Solute Carrier Family 44, Member 1 3
  • Solute Carrier Family 44 Member 1 4
  • CD92 Antigen 4
  • CHTL1 3

External Ids for SLC44A1 Gene

Previous HGNC Symbols for SLC44A1 Gene

  • CDW92

Previous GeneCards Identifiers for SLC44A1 Gene

  • GC09P105087
  • GC09P107046
  • GC09P108006
  • GC09P077662

Summaries for SLC44A1 Gene

GeneCards Summary for SLC44A1 Gene

SLC44A1 (Solute Carrier Family 44 (Choline Transporter), Member 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include choline transmembrane transporter activity. An important paralog of this gene is SLC44A3.

UniProtKB/Swiss-Prot for SLC44A1 Gene

  • Choline transporter. May be involved in membrane synthesis and myelin production.

Gene Wiki entry for SLC44A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC44A1 Gene

Genomics for SLC44A1 Gene

Regulatory Elements for SLC44A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC44A1 Gene

105,244,613 bp from pter
105,439,171 bp from pter
194,559 bases
Plus strand

Genomic View for SLC44A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC44A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC44A1 Gene

Proteins for SLC44A1 Gene

  • Protein details for SLC44A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Choline transporter-like protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NLZ9
    • Q5VUB3
    • Q8WVB0
    • Q96KU3
    • Q9NY69

    Protein attributes for SLC44A1 Gene

    657 amino acids
    Molecular mass:
    73302 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC44A1 Gene


neXtProt entry for SLC44A1 Gene

Proteomics data for SLC44A1 Gene at MOPED

Post-translational modifications for SLC44A1 Gene

  • Ubiquitination at Lys648
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC44A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC44A1 Gene

Domains for SLC44A1 Gene

Gene Families for SLC44A1 Gene

  • CD :CD molecules
  • SLC :Solute carriers

Protein Domains for SLC44A1 Gene


Suggested Antigen Peptide Sequences for SLC44A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8WWI5
  • Belongs to the CTL (choline transporter-like) family.
genes like me logo Genes that share domains with SLC44A1: view

Function for SLC44A1 Gene

Molecular function for SLC44A1 Gene

UniProtKB/Swiss-Prot Function: Choline transporter. May be involved in membrane synthesis and myelin production.

Gene Ontology (GO) - Molecular Function for SLC44A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015220 choline transmembrane transporter activity TAS 10677542
genes like me logo Genes that share ontologies with SLC44A1: view

Animal Model Products

CRISPR Products

miRNA for SLC44A1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC44A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC44A1 Gene

Localization for SLC44A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC44A1 Gene

Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC44A1 Gene COMPARTMENTS Subcellular localization image for SLC44A1 gene
Compartment Confidence
mitochondrion 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC44A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane TAS 10677542
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC44A1: view

Pathways for SLC44A1 Gene

genes like me logo Genes that share pathways with SLC44A1: view

Gene Ontology (GO) - Biological Process for SLC44A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0015871 choline transport TAS 10677542
GO:0044281 small molecule metabolic process TAS --
GO:0046474 glycerophospholipid biosynthetic process TAS --
genes like me logo Genes that share ontologies with SLC44A1: view

Compounds for SLC44A1 Gene

(1) HMDB Compounds for SLC44A1 Gene

Compound Synonyms Cas Number PubMed IDs
  • (2-Hydroxyethyl)trimethyl ammonium

(1) Drugbank Compounds for SLC44A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • Bilineurine
62-49-7 transporter substrate

(1) IUPHAR Ligand for SLC44A1 Gene

Ligand Type Action Affinity Pubmed IDs
hemicholinium-3 Inhibitor Inhibition 4.5

(1) Novoseek inferred chemical compound relationships for SLC44A1 Gene

Compound -log(P) Hits PubMed IDs
choline 79.2 27
genes like me logo Genes that share compounds with SLC44A1: view

Transcripts for SLC44A1 Gene

Unigene Clusters for SLC44A1 Gene

Solute carrier family 44, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC44A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC44A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20
SP1: - - -
SP2: - - - - -
SP3: - - - - - -

Relevant External Links for SLC44A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC44A1 Gene

mRNA expression in normal human tissues for SLC44A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC44A1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC44A1 Gene

SOURCE GeneReport for Unigene cluster for SLC44A1 Gene Hs.573495

mRNA Expression by UniProt/SwissProt for SLC44A1 Gene

Tissue specificity: Expressed in various cells of the hematopoietic system.
genes like me logo Genes that share expressions with SLC44A1: view

In Situ Assay Products

Orthologs for SLC44A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC44A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC44A1 35
  • 99.78 (n)
  • 99.84 (a)
SLC44A1 36
  • 100 (a)
(Bos Taurus)
Mammalia SLC44A1 35
  • 93.99 (n)
  • 96.08 (a)
SLC44A1 36
  • 64 (a)
(Canis familiaris)
Mammalia SLC44A1 35
  • 94.26 (n)
  • 97.1 (a)
SLC44A1 36
  • 98 (a)
(Mus musculus)
Mammalia Slc44a1 35
  • 90.65 (n)
  • 95.69 (a)
Slc44a1 16
Slc44a1 36
  • 96 (a)
(Monodelphis domestica)
Mammalia SLC44A1 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia SLC44A1 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Slc44a1 35
  • 90.5 (n)
  • 96.04 (a)
(Gallus gallus)
Aves SLC44A1 35
  • 82.35 (n)
  • 87.46 (a)
SLC44A1 36
  • 88 (a)
(Anolis carolinensis)
Reptilia SLC44A1 36
  • 88 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16481 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc44a1 35
  • 77.79 (n)
  • 85.23 (a)
Str.10457 35
(Danio rerio)
Actinopterygii SLC44A1 (2 of 3) 36
  • 66 (a)
slc44a1a 35
  • 66.31 (n)
  • 72.49 (a)
slc44a1a 36
  • 72 (a)
slc44a1b 36
  • 80 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta CTLH1_ANOGA 35
  • 47.37 (n)
  • 40.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1311 35
  • 50.26 (n)
  • 39.13 (a)
CG1311 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PNS1 36
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1906 36
  • 44 (a)
Species with no ortholog for SLC44A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC44A1 Gene

Gene Tree for SLC44A1 (if available)
Gene Tree for SLC44A1 (if available)

Paralogs for SLC44A1 Gene

Paralogs for SLC44A1 Gene

Selected SIMAP similar genes for SLC44A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC44A1: view

Variants for SLC44A1 Gene

Sequence variations from dbSNP and Humsavar for SLC44A1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs11096 -- 105,397,007(+) ACTTT(A/G)CAGAT utr-variant-3-prime, intron-variant
rs170582 -- 105,248,163(-) AGTTG(C/T)TGAAG intron-variant
rs179177 -- 105,280,984(-) ATCTT(A/G)AGAGG intron-variant
rs182756 -- 105,261,588(-) CCAGC(C/T)TGGGA intron-variant
rs186617 -- 105,289,108(+) ATGTA(A/G)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC44A1 Gene

Variant ID Type Subtype PubMed ID
nsv831678 CNV Gain+Loss 17160897
nsv893685 CNV Loss 21882294
dgv8271n71 CNV Loss 21882294
nsv893689 CNV Loss 21882294
nsv893691 CNV Loss 21882294
esv2738882 CNV Deletion 23290073
esv2657248 CNV Deletion 23128226

Relevant External Links for SLC44A1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC44A1 Gene

Disorders for SLC44A1 Gene

Relevant External Links for SLC44A1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with SLC44A1: view

No data available for UniProtKB/Swiss-Prot for SLC44A1 Gene

Publications for SLC44A1 Gene

  1. Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells. (PMID: 11698453) Wille S. … Stockinger H. (J. Immunol. 2001) 2 3 4 23
  2. An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins. (PMID: 10677542) O'Regan S. … Meunier F.-M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4
  3. Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 monocyte-derived macrophages. (PMID: 16319125) Fullerton M.D. … Bakovic M. (Am. J. Physiol., Cell Physiol. 2006) 3 23 25
  4. Detection of choline transporter-like 1 protein CTL1 in neuroblastoma x glioma cells and in the CNS, and its role in choline uptake. (PMID: 19519661) MachovA! E. … Dolezal V. (J. Neurochem. 2009) 3 23
  5. Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake. (PMID: 20410607) Nakamura T. … Tamai I. (Biol. Pharm. Bull. 2010) 3 23

Products for SLC44A1 Gene

Sources for SLC44A1 Gene

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