Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC44A1 Gene

Aliases for SLC44A1 Gene

  • Solute Carrier Family 44 Member 1 2 3 4
  • Solute Carrier Family 44 (Choline Transporter), Member 1 2 3 5
  • CDW92 Antigen 2 3
  • CDW92 3 4
  • CD92 3 4
  • CTL1 3 4
  • Solute Carrier Family 44, Member 1 3
  • CD92 Antigen 4
  • CHTL1 3

External Ids for SLC44A1 Gene

Previous HGNC Symbols for SLC44A1 Gene

  • CDW92

Previous GeneCards Identifiers for SLC44A1 Gene

  • GC09P105087
  • GC09P107046
  • GC09P108006
  • GC09P077662

Summaries for SLC44A1 Gene

GeneCards Summary for SLC44A1 Gene

SLC44A1 (Solute Carrier Family 44 Member 1) is a Protein Coding gene. Diseases associated with SLC44A1 include Postural Orthostatic Tachycardia Syndrome. Among its related pathways are Glycerophospholipid biosynthesis and Metabolism. GO annotations related to this gene include choline transmembrane transporter activity. An important paralog of this gene is SLC44A3.

UniProtKB/Swiss-Prot for SLC44A1 Gene

  • Choline transporter. May be involved in membrane synthesis and myelin production.

Gene Wiki entry for SLC44A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC44A1 Gene

Genomics for SLC44A1 Gene

Regulatory Elements for SLC44A1 Gene

Enhancers for SLC44A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC44A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLC44A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC44A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC44A1 Gene

Chromosome:
9
Start:
105,244,608 bp from pter
End:
105,439,171 bp from pter
Size:
194,564 bases
Orientation:
Plus strand

Genomic View for SLC44A1 Gene

Genes around SLC44A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC44A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC44A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC44A1 Gene

Proteins for SLC44A1 Gene

  • Protein details for SLC44A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWI5-CTL1_HUMAN
    Recommended name:
    Choline transporter-like protein 1
    Protein Accession:
    Q8WWI5
    Secondary Accessions:
    • A6NLZ9
    • Q5VUB3
    • Q8WVB0
    • Q96KU3
    • Q9NY69

    Protein attributes for SLC44A1 Gene

    Size:
    657 amino acids
    Molecular mass:
    73302 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC44A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC44A1 Gene

Proteomics data for SLC44A1 Gene at MOPED

Post-translational modifications for SLC44A1 Gene

  • Ubiquitination at Lys 648
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC44A1 Gene

No data available for DME Specific Peptides for SLC44A1 Gene

Domains & Families for SLC44A1 Gene

Gene Families for SLC44A1 Gene

Protein Domains for SLC44A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC44A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWI5

UniProtKB/Swiss-Prot:

CTL1_HUMAN :
  • Belongs to the CTL (choline transporter-like) family.
Family:
  • Belongs to the CTL (choline transporter-like) family.
genes like me logo Genes that share domains with SLC44A1: view

Function for SLC44A1 Gene

Molecular function for SLC44A1 Gene

UniProtKB/Swiss-Prot Function:
Choline transporter. May be involved in membrane synthesis and myelin production.
genes like me logo Genes that share phenotypes with SLC44A1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC44A1 Gene

Localization for SLC44A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC44A1 Gene

Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC44A1 Gene COMPARTMENTS Subcellular localization image for SLC44A1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
plasma membrane 5
nucleus 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC44A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane IEA,TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC44A1: view

Pathways & Interactions for SLC44A1 Gene

genes like me logo Genes that share pathways with SLC44A1: view

Pathways by source for SLC44A1 Gene

Gene Ontology (GO) - Biological Process for SLC44A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0015871 choline transport TAS 10677542
GO:0042426 choline catabolic process TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC44A1: view

No data available for SIGNOR curated interactions for SLC44A1 Gene

Drugs & Compounds for SLC44A1 Gene

(2) Drugs for SLC44A1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Choline Approved Nutra Transporter, substrate 139
hemicholinium-3 Pharma Inhibition, Inhibitor 0
genes like me logo Genes that share compounds with SLC44A1: view

Transcripts for SLC44A1 Gene

Unigene Clusters for SLC44A1 Gene

Solute carrier family 44, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC44A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20
SP1: - - -
SP2: - - - - -
SP3: - - - - - -
SP4:
SP5:

Relevant External Links for SLC44A1 Gene

GeneLoc Exon Structure for
SLC44A1
ECgene alternative splicing isoforms for
SLC44A1

Expression for SLC44A1 Gene

mRNA expression in normal human tissues for SLC44A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC44A1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.9).

Protein differential expression in normal tissues from HIPED for SLC44A1 Gene

This gene is overexpressed in Nasal epithelium (45.0) and Spinal cord (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC44A1 Gene



SOURCE GeneReport for Unigene cluster for SLC44A1 Gene Hs.573495

mRNA Expression by UniProt/SwissProt for SLC44A1 Gene

Q8WWI5-CTL1_HUMAN
Tissue specificity: Expressed in various cells of the hematopoietic system.
genes like me logo Genes that share expression patterns with SLC44A1: view

Protein tissue co-expression partners for SLC44A1 Gene

Primer Products

Orthologs for SLC44A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC44A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC44A1 35
  • 93.99 (n)
  • 96.08 (a)
SLC44A1 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC44A1 35
  • 94.26 (n)
  • 97.1 (a)
SLC44A1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc44a1 35
  • 90.65 (n)
  • 95.69 (a)
Slc44a1 16
Slc44a1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC44A1 35
  • 99.78 (n)
  • 99.84 (a)
SLC44A1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc44a1 35
  • 90.5 (n)
  • 96.04 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC44A1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC44A1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC44A1 35
  • 82.35 (n)
  • 87.46 (a)
SLC44A1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC44A1 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc44a1 35
  • 77.79 (n)
  • 85.23 (a)
Str.10457 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16481 35
zebrafish
(Danio rerio)
Actinopterygii slc44a1a 35
  • 66.31 (n)
  • 72.49 (a)
SLC44A1 (2 of 3) 36
  • 66 (a)
OneToMany
slc44a1a 36
  • 72 (a)
OneToMany
slc44a1b 36
  • 80 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta CTLH1_ANOGA 35
  • 47.37 (n)
  • 40.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1311 35
  • 50.26 (n)
  • 39.13 (a)
CG1311 36
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PNS1 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1906 36
  • 44 (a)
OneToMany
Species with no ortholog for SLC44A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC44A1 Gene

ENSEMBL:
Gene Tree for SLC44A1 (if available)
TreeFam:
Gene Tree for SLC44A1 (if available)

Paralogs for SLC44A1 Gene

Paralogs for SLC44A1 Gene

(3) SIMAP similar genes for SLC44A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC44A1: view

Variants for SLC44A1 Gene

Sequence variations from dbSNP and Humsavar for SLC44A1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3199966 - 105,385,482(+) CTGAT(G/T)CCAGA reference, missense
rs724068 -- 105,403,797(-) CATTT(C/T)TTCAC intron-variant
rs724069 -- 105,403,632(-) AATCA(C/T)CTGCT intron-variant
rs907230 -- 105,338,171(-) TTTTA(C/T)AGCTT intron-variant
rs932005 -- 105,327,730(+) CACTG(A/G)TTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC44A1 Gene

Variant ID Type Subtype PubMed ID
nsv831678 CNV Gain+Loss 17160897
nsv893685 CNV Loss 21882294
dgv8271n71 CNV Loss 21882294
nsv893689 CNV Loss 21882294
nsv893691 CNV Loss 21882294
esv2738882 CNV Deletion 23290073
esv2657248 CNV Deletion 23128226

Variation tolerance for SLC44A1 Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.40; 81.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC44A1 Gene

Disorders for SLC44A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC44A1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
postural orthostatic tachycardia syndrome
  • chronic othostatic intolerance
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC44A1

Genetic Association Database (GAD)
SLC44A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC44A1
genes like me logo Genes that share disorders with SLC44A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC44A1 Gene

Publications for SLC44A1 Gene

  1. Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells. (PMID: 11698453) Wille S. … Stockinger H. (J. Immunol. 2001) 2 3 4 23 67
  2. Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 monocyte-derived macrophages. (PMID: 16319125) Fullerton M.D. … Bakovic M. (Am. J. Physiol., Cell Physiol. 2006) 3 23 25
  3. Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake. (PMID: 20410607) Nakamura T. … Tamai I. (Biol. Pharm. Bull. 2010) 3 23
  4. Detection of choline transporter-like 1 protein CTL1 in neuroblastoma x glioma cells and in the CNS, and its role in choline uptake. (PMID: 19519661) MachovA! E. … Dolezal V. (J. Neurochem. 2009) 3 23
  5. Decreased biosynthesis of lung surfactant constituent phosphatidylcholine due to inhibition of choline transporter by gefitinib in lung alveolar cells. (PMID: 17624579) Ishiguro N. … Tamai I. (Pharm. Res. 2008) 23 25

Products for SLC44A1 Gene

Sources for SLC44A1 Gene

Content