Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC43A3 Gene

Aliases for SLC43A3 Gene

  • Solute Carrier Family 43 Member 3 2 3 5
  • Likely Ortholog Of Mouse Embryonic Epithelial Gene 1 2 3
  • Solute Carrier Family 43, Member 3 2 3
  • Protein FOAP-13 4
  • FOAP-13 3
  • PRO1659 3
  • SEEEG-1 3
  • EEG1 3

External Ids for SLC43A3 Gene

Previous GeneCards Identifiers for SLC43A3 Gene

  • GC11M056950
  • GC11M056931
  • GC11M057174
  • GC11M053523

Summaries for SLC43A3 Gene

GeneCards Summary for SLC43A3 Gene

SLC43A3 (Solute Carrier Family 43 Member 3) is a Protein Coding gene. An important paralog of this gene is ENSG00000254979.

UniProtKB/Swiss-Prot for SLC43A3 Gene

  • Putative transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC43A3 Gene

Genomics for SLC43A3 Gene

Regulatory Elements for SLC43A3 Gene

Enhancers for SLC43A3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC43A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC43A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC43A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC43A3 Gene

Chromosome:
11
Start:
57,406,954 bp from pter
End:
57,427,580 bp from pter
Size:
20,627 bases
Orientation:
Minus strand

Genomic View for SLC43A3 Gene

Genes around SLC43A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC43A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC43A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC43A3 Gene

Proteins for SLC43A3 Gene

  • Protein details for SLC43A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBI5-S43A3_HUMAN
    Recommended name:
    Solute carrier family 43 member 3
    Protein Accession:
    Q8NBI5
    Secondary Accessions:
    • B4DNR8
    • E7EQD2
    • Q9NSS4

    Protein attributes for SLC43A3 Gene

    Size:
    491 amino acids
    Molecular mass:
    54529 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC43A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC43A3 Gene

Proteomics data for SLC43A3 Gene at MOPED

Post-translational modifications for SLC43A3 Gene

  • Ubiquitination at Lys 249 and Lys 255
  • Glycosylation at Asn 56, Asn 220, and Asn 229
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SLC43A3 Gene

Domains & Families for SLC43A3 Gene

Gene Families for SLC43A3 Gene

HGNC:
IUPHAR :

Protein Domains for SLC43A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC43A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBI5

UniProtKB/Swiss-Prot:

S43A3_HUMAN :
  • Belongs to the SLC43A transporter (TC 2.A.1.44) family.
Family:
  • Belongs to the SLC43A transporter (TC 2.A.1.44) family.
genes like me logo Genes that share domains with SLC43A3: view

Function for SLC43A3 Gene

Molecular function for SLC43A3 Gene

UniProtKB/Swiss-Prot Function:
Putative transporter.
genes like me logo Genes that share phenotypes with SLC43A3: view

Animal Model Products

CRISPR Products

miRNA for SLC43A3 Gene

miRTarBase miRNAs that target SLC43A3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC43A3 Gene

Localization for SLC43A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC43A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC43A3 Gene COMPARTMENTS Subcellular localization image for SLC43A3 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for SLC43A3 Gene

Pathways & Interactions for SLC43A3 Gene

SuperPathways for SLC43A3 Gene

No Data Available

Interacting Proteins for SLC43A3 Gene

Gene Ontology (GO) - Biological Process for SLC43A3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC43A3 Gene

Drugs & Compounds for SLC43A3 Gene

No Compound Related Data Available

Transcripts for SLC43A3 Gene

Unigene Clusters for SLC43A3 Gene

Solute carrier family 43, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC43A3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: -
SP5:
SP6: - - - -
SP7: - - - - - -
SP8: -
SP9: - - -
SP10: - - - - - - -
SP11: - - - -
SP12: - - - - - - - -
SP13: - - - - -
SP14: - - - - - -
SP15: - - - - -
SP16: - - - - - -
SP17: - - -
SP18: - - - - - -

ExUns: 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for SLC43A3 Gene

GeneLoc Exon Structure for
SLC43A3
ECgene alternative splicing isoforms for
SLC43A3

Expression for SLC43A3 Gene

mRNA expression in normal human tissues for SLC43A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC43A3 Gene

This gene is overexpressed in Liver (x5.4).

Protein differential expression in normal tissues from HIPED for SLC43A3 Gene

This gene is overexpressed in Urine (31.6) and Breast (23.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC43A3 Gene



SOURCE GeneReport for Unigene cluster for SLC43A3 Gene Hs.99962

mRNA Expression by UniProt/SwissProt for SLC43A3 Gene

Q8NBI5-S43A3_HUMAN
Tissue specificity: Highly expressed in macrophages.
genes like me logo Genes that share expression patterns with SLC43A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for SLC43A3 Gene

Orthologs for SLC43A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC43A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC43A3 35
  • 82.17 (n)
  • 77.66 (a)
SLC43A3 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC43A3 35
  • 84.01 (n)
  • 82.86 (a)
SLC43A3 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc43a3 35
  • 79.49 (n)
  • 76.54 (a)
Slc43a3 16
Slc43a3 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC43A3 35
  • 95.93 (n)
  • 94.7 (a)
SLC43A3 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc43a3 35
  • 79.18 (n)
  • 76.91 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC43A3 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC43A3 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC43A3 35
  • 65.96 (n)
  • 58.3 (a)
SLC43A3 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC43A3 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.26648 35
slc43a3b 35
  • 61.12 (n)
  • 59.61 (a)
slc43a3a 36
  • 52 (a)
OneToMany
slc43a3b 36
  • 56 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07040g 35
  • 40.14 (n)
  • 26.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMR221C 35
  • 44.85 (n)
  • 35.15 (a)
-- 36
  • 19 (a)
OneToMany
-- 38
bread mold
(Neurospora crassa)
Ascomycetes NCU10987 35
  • 44.44 (n)
  • 27.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 27 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
Species with no ortholog for SLC43A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC43A3 Gene

ENSEMBL:
Gene Tree for SLC43A3 (if available)
TreeFam:
Gene Tree for SLC43A3 (if available)

Paralogs for SLC43A3 Gene

Paralogs for SLC43A3 Gene

genes like me logo Genes that share paralogs with SLC43A3: view

Variants for SLC43A3 Gene

Sequence variations from dbSNP and Humsavar for SLC43A3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs34799622 - 57,426,015(+) CAATC(A/C/G)GCCCA reference, missense
rs1049272 -- 57,407,157(-) TGTCC(G/T)AGAAG utr-variant-3-prime
rs1049273 -- 57,407,111(-) GGGCC(A/G)TGGGA utr-variant-3-prime
rs1151049 -- 57,429,534(+) CCTAT(G/T)GATTT upstream-variant-2KB
rs2241899 -- 57,409,155(-) GATGG(A/G)GATCC intron-variant

Variation tolerance for SLC43A3 Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for SLC43A3 Gene

Disorders for SLC43A3 Gene

Relevant External Links for SLC43A3

Genetic Association Database (GAD)
SLC43A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC43A3

No disorders were found for SLC43A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC43A3 Gene

Publications for SLC43A3 Gene

  1. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 3 48 67
  2. EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis. (PMID: 11704567) Stuart R.O. … Nigam S.K. (Am. J. Physiol. Renal Physiol. 2001) 2 3
  3. Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. (PMID: 7531438) Li M.S. … Spry C.J. (Biochem. J. 1995) 2 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. NUP160-SLC43A3 Is a Novel Recurrent Fusion Oncogene in Angiosarcoma. (PMID: 26527604) Shimozono N. … Ihn H. (Cancer Res. 2015) 3

Products for SLC43A3 Gene

Sources for SLC43A3 Gene

Content