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Aliases for SLC43A3 Gene

Aliases for SLC43A3 Gene

  • Solute Carrier Family 43, Member 3 2 3
  • Likely Ortholog Of Mouse Embryonic Epithelial Gene 1 2 3
  • Solute Carrier Family 43 Member 3 3
  • Protein FOAP-13 4
  • FOAP-13 3
  • PRO1659 3
  • SEEEG-1 3
  • EEG1 3

External Ids for SLC43A3 Gene

Previous GeneCards Identifiers for SLC43A3 Gene

  • GC11M056950
  • GC11M056931
  • GC11M057174
  • GC11M053523

Summaries for SLC43A3 Gene

GeneCards Summary for SLC43A3 Gene

SLC43A3 (Solute Carrier Family 43, Member 3) is a Protein Coding gene. An important paralog of this gene is SLC43A1.

UniProtKB/Swiss-Prot for SLC43A3 Gene

  • Putative transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC43A3 Gene

Genomics for SLC43A3 Gene

Regulatory Elements for SLC43A3 Gene

Genomic Location for SLC43A3 Gene

Start:
57,406,954 bp from pter
End:
57,427,580 bp from pter
Size:
20,627 bases
Orientation:
Minus strand

Genomic View for SLC43A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC43A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC43A3 Gene

Proteins for SLC43A3 Gene

  • Protein details for SLC43A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBI5-S43A3_HUMAN
    Recommended name:
    Solute carrier family 43 member 3
    Protein Accession:
    Q8NBI5
    Secondary Accessions:
    • B4DNR8
    • E7EQD2
    • Q9NSS4

    Protein attributes for SLC43A3 Gene

    Size:
    491 amino acids
    Molecular mass:
    54529 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC43A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC43A3 Gene

Proteomics data for SLC43A3 Gene at MOPED

Post-translational modifications for SLC43A3 Gene

  • Ubiquitination at Lys249, Lys255, and Lys264
  • Glycosylation at Asn56, Asn220, and Asn229
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC43A3 Gene

Domains for SLC43A3 Gene

Gene Families for SLC43A3 Gene

Protein Domains for SLC43A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC43A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBI5

UniProtKB/Swiss-Prot:

S43A3_HUMAN :
  • Q8NBI5
Family:
  • Belongs to the SLC43A transporter (TC 2.A.1.44) family.
genes like me logo Genes that share domains with SLC43A3: view

Function for SLC43A3 Gene

Molecular function for SLC43A3 Gene

UniProtKB/Swiss-Prot Function: Putative transporter.

Gene Ontology (GO) - Molecular Function for SLC43A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SLC43A3: view

Phenotypes for SLC43A3 Gene

genes like me logo Genes that share phenotypes with SLC43A3: view

Animal Model Products

CRISPR Products

miRNA for SLC43A3 Gene

miRTarBase miRNAs that target SLC43A3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC43A3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC43A3 Gene

Localization for SLC43A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC43A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC43A3 Gene COMPARTMENTS Subcellular localization image for SLC43A3 gene
Compartment Confidence
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SLC43A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC43A3: view

Pathways for SLC43A3 Gene

SuperPathways for SLC43A3 Gene

No Data Available

Interacting Proteins for SLC43A3 Gene

Gene Ontology (GO) - Biological Process for SLC43A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC43A3: view

No data available for Pathways by source for SLC43A3 Gene

Transcripts for SLC43A3 Gene

Unigene Clusters for SLC43A3 Gene

Solute carrier family 43, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC43A3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC43A3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: -
SP5:
SP6: - - - -
SP7: - - - - - -
SP8: -
SP9: - - -
SP10: - - - - - - -
SP11: - - - -
SP12: - - - - - - - -
SP13: - - - - -
SP14: - - - - - -
SP15: - - - - -
SP16: - - - - - -
SP17: - - -
SP18: - - - - - -

ExUns: 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for SLC43A3 Gene

GeneLoc Exon Structure for
SLC43A3
ECgene alternative splicing isoforms for
SLC43A3

Expression for SLC43A3 Gene

mRNA expression in normal human tissues for SLC43A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC43A3 Gene

This gene is overexpressed in Liver (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC43A3 Gene

SOURCE GeneReport for Unigene cluster for SLC43A3 Gene Hs.99962

mRNA Expression by UniProt/SwissProt for SLC43A3 Gene

Q8NBI5-S43A3_HUMAN
Tissue specificity: Highly expressed in macrophages.
genes like me logo Genes that share expressions with SLC43A3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC43A3 Gene

Orthologs for SLC43A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC43A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC43A3 35
  • 95.93 (n)
  • 94.7 (a)
SLC43A3 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC43A3 35
  • 82.17 (n)
  • 77.66 (a)
SLC43A3 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC43A3 35
  • 84.01 (n)
  • 82.86 (a)
SLC43A3 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc43a3 35
  • 79.49 (n)
  • 76.54 (a)
Slc43a3 16
Slc43a3 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC43A3 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC43A3 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc43a3 35
  • 79.18 (n)
  • 76.91 (a)
chicken
(Gallus gallus)
Aves SLC43A3 35
  • 65.96 (n)
  • 58.3 (a)
SLC43A3 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC43A3 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.26648 35
slc43a3a 36
  • 52 (a)
OneToMany
slc43a3b 35
  • 61.12 (n)
  • 59.61 (a)
slc43a3b 36
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 19 (a)
OneToMany
-- 38
YMR221C 35
  • 44.85 (n)
  • 35.15 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07040g 35
  • 40.14 (n)
  • 26.13 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10987 35
  • 44.44 (n)
  • 27.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 27 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
Species with no ortholog for SLC43A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC43A3 Gene

ENSEMBL:
Gene Tree for SLC43A3 (if available)
TreeFam:
Gene Tree for SLC43A3 (if available)

Paralogs for SLC43A3 Gene

Paralogs for SLC43A3 Gene

genes like me logo Genes that share paralogs with SLC43A3: view

Variants for SLC43A3 Gene

Sequence variations from dbSNP and Humsavar for SLC43A3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7124 -- 57,407,086(-) TTGAC(C/T)GAAGG utr-variant-3-prime
rs1049272 -- 57,407,157(-) TGTCC(G/T)AGAAG utr-variant-3-prime
rs1049273 -- 57,407,111(-) GGGCC(A/G)TGGGA utr-variant-3-prime
rs1151049 -- 57,429,534(+) CCTAT(G/T)GATTT upstream-variant-2KB
rs2241899 -- 57,409,155(-) GATGG(A/G)GATCC intron-variant

Relevant External Links for SLC43A3 Gene

HapMap Linkage Disequilibrium report
SLC43A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC43A3 Gene

Disorders for SLC43A3 Gene

Relevant External Links for SLC43A3

Genetic Association Database (GAD)
SLC43A3
genes like me logo Genes that share disorders with SLC43A3: view

No data available for UniProtKB/Swiss-Prot for SLC43A3 Gene

Publications for SLC43A3 Gene

  1. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 3 48
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  3. Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. (PMID: 7531438) Li M.S. … Spry C.J. (Biochem. J. 1995) 2 3
  4. EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis. (PMID: 11704567) Stuart R.O. … Nigam S.K. (Am. J. Physiol. Renal Physiol. 2001) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC43A3 Gene

Sources for SLC43A3 Gene

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