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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC43A3 Gene

protein-coding GIFtS: 47
GCID: GC11M057174

Solute Carrier Family 43, Member 3

1 related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Solute Carrier Family 43, Member 3¹ ²		PRO1659²
Likely Ortholog Of Mouse Embryonic Epithelial Gene 1¹ ²		SEEEG-1²
EEG1²		Solute Carrier Family 43 Member 3²
FOAP-13²		Protein FOAP-13³

External Ids:	HGNC: 17466¹	Entrez Gene: 29015²	Ensembl: ENSG00000134802⁷	UniProtKB: Q8NBI5³

Export aliases for SLC43A3 gene to outside databases

Previous GC identifers: GC11M056950 GC11M056931 GC11M053523

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC43A3 Gene:

SLC43A3 (solute carrier family 43, member 3) is a protein-coding gene. Diseases associated with SLC43A3 include crohn's disease. An important paralog of this gene is SLC43A2.

UniProtKB/Swiss-Prot: S43A3_HUMAN, Q8NBI5

Function: Putative transporter (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NT_167190.1 NC_018922.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC43A3 gene promoter:
HFH-3 FOXI1 NRF-2 FOXL1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SLC43A3 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC43A3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC43A3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q11

SLC43A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC43A3 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M057174: view genomic region (about GC identifiers)

Start:	57,174,427 bp from pter	End:	57,195,053 bp from pter
Size:	20,627 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S43A3_HUMAN, Q8NBI5 (See protein sequence)

Recommended Name: Solute carrier family 43 member 3

Size: 491 amino acids; 54529 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q9NSS4

Explore the universe of human proteins at neXtProt for SLC43A3: NX_Q8NBI5

Explore proteomics data for SLC43A3 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8NBI5

SLC43A3 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (5 alternative transcripts):

NP_001265130.1 NP_001265135.1 NP_054815.2 NP_060081.1 NP_955361.1

ENSEMBL proteins:

ENSP00000378555 ENSP00000378556 ENSP00000337561 ENSP00000436254 ENSP00000433078

ENSP00000434515 ENSP00000435893 ENSP00000434293 ENSP00000436055 ENSP00000434913

ENSP00000435273 ENSP00000433974 ENSP00000431762 ENSP00000435156 ENSP00000434569

ENSP00000435109 ENSP00000435490 ENSP00000431367 ENSP00000434710 ENSP00000431765

ENSP00000433393 ENSP00000434371

Human Recombinant Protein Products for SLC43A3:

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	Novus Biologicals SLC43A3 Protein Novus Biologicals SLC43A3 Lysates
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	Cloud-Clone Corp. Proteins for SLC43A3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

SLC43A3 for ontologies About GeneDecksing

SLC43A3 Antibody Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: EEG1

SLC43 family of large neutral amino acid transporters

4 InterPro protein domains:

IPR027197 SLC43A3

IPR011701 MFS

IPR016196 MFS_dom_general_subst_transpt

IPR027192 SLC43

Graphical View of Domain Structure for InterPro Entry Q8NBI5

ProtoNet protein and cluster: Q8NBI5

UniProtKB/Swiss-Prot: S43A3_HUMAN, Q8NBI5

Similarity: Belongs to the SLC43A transporter (TC 2.A.1.44) family

SLC43A3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: S43A3_HUMAN, Q8NBI5

Function: Putative transporter (By similarity)

Phenotypes:
2 GenomeRNAi human phenotypes for SLC43A3:

Decreased viability with cispl

Synthetic lethal with c-Myc af

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC43A3

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC43A3

miRNA Products:
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		hsa-miR-3163
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		OriGene clones in human, mouse for SLC43A3 (see all 20) OriGene ORF clones in mouse, rat for SLC43A3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC43A3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC43A3

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SLC43A3 (ENSP00000337561⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
LAMC3	ENSP00000354360⁴	STRING: ENSP00000354360

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0055085	transmembrane transport	IEA	--

SLC43A3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC43A3 (S43A3)

Search CenterWatch for drugs/clinical trials and news about SLC43A3 / S43A3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC43A3 gene (5 alternative transcripts):

NM_001278201.1 NM_001278206.1 NM_014096.3 NM_017611.2 NM_199329.2

Unigene Cluster for SLC43A3:

Solute carrier family 43, member 3

Hs.99962 [show with all ESTs]

Unigene Representative Sequence: NM_014096

18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):

ENST00000395123(uc001nkg.3) ENST00000395124(uc001nkh.3 uc010rjr.2 uc009yme.3)

ENST00000352187(uc001nki.3) ENST00000529554 ENST00000525205 ENST00000533524(uc009ymg.1)

ENST00000530005(uc009ymf.1) ENST00000528098(uc010rjs.1) ENST00000529113

ENST00000525474 ENST00000529112 ENST00000526125 ENST00000530232 ENST00000528187

ENST00000529494 ENST00000533245 ENST00000533235 ENST00000524863

miRNA Products:
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		hsa-miR-3163
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Clone Products:		OriGene clones in human, mouse for SLC43A3 (see all 20) OriGene ORF clones in mouse, rat for SLC43A3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Additional mRNA sequence:

AB028927.1 AF118070.1 AK075552.1 AK290391.1 AK298028.1 AK300977.1 AK311394.1 AK311401.1

AK315839.1 AL157431.1 BC003163.1 CR457391.1

21 DOTS entries:

DT.97767574 DT.75134243 DT.100654796 DT.99948191 DT.100654800 DT.95194818 DT.95194802 DT.95194809

DT.100654797 DT.100697572 DT.92394980 DT.95194816 DT.100660307 DT.91771616 DT.100042068 DT.100803256

DT.120728564 DT.95188227 DT.95194804 DT.97862181 DT.121441976

24/873 AceView cDNA sequences (see all 873):

C17720 CR606261 CR618388 BU624342 CR618883 CR599398 AW779414 AA286984

CR603683 CR590778 CR622244 CA310160 CR600307 BU628614 CR597111 AA284125

CR603205 NM_017611 CR624403 BM455796 BQ446791 CR593939 CR615951 AI074500

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for SLC43A3 (see all 18) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	^
SP1:			-		-		-		-		-		-				-														-
SP2:									-		-		-				-														-
SP3:									-		-		-				-						-		-						-
SP4:																															-
SP5:

ExUns:	14a	·	14b	·	14c	·	14d	^	15	^	16	^	17	^	18	^	19
SP1:	-
SP2:	-
SP3:
SP4:
SP5:													-

ECgene alternative splicing isoforms for SLC43A3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC43A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGAGCCAGCT

About this image

See SLC43A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC43A3

SOURCE GeneReport for Unigene cluster: Hs.99962

UniProtKB/Swiss-Prot: S43A3_HUMAN, Q8NBI5

Tissue specificity: Highly expressed in macrophages

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC43A3 gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Slc43a3^{1 , 5}	solute carrier family 43, member 3^{1, 5}	79.49(n)¹ 76.54(a)¹		2 (49.45 cM)⁵ 58207¹ NM_021398.3¹ NP_067373.2¹ 84936579⁵
chicken (Gallus gallus)	Aves	SLC43A3¹	solute carrier family 43, member 3	65.46(n) 57.87(a)		423133 XM_003641377.1 XP_003641425.1
lizard (Anolis carolinensis)	Reptilia	SLC43A3⁶	solute carrier family 43, member 3	50(a)	1 ↔ 1	1(92028910-92066967)
zebrafish (Danio rerio)	Actinopterygii	Dr.26648²	Danio rerio cDNA clone IMAGE3820673, partial cds	73.83(n)		BC054919.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	(YMR221C)⁴ YMR221C¹	Putative protein of unknown function; the authentic, more⁴ hypothetical protein¹	38.54(n)¹ 24.94(a)¹		13(715445-713931)⁴ 855261^{1, 4} NP_013948.1^{1, 4}

ENSEMBL Gene Tree for SLC43A3 (if available)
TreeFam Gene Tree for SLC43A3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC43A3 gene

SLC43A2² SLC43A1²

2 SIMAP similar genes for SLC43A3 using alignment to 18 protein entries: S43A3_HUMAN (see all proteins):

SLC43A1 SLC43A2

SLC43A3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187274214^1,2		--	57173958(+)	`GCAGTG/TGCAAT`	5	--	ds500¹ int¹		0	--	--	--	--
rs138059169^1,2		--	57174004(+)	`AATGAC/TTAACT`	5	--	ds500¹ int¹		0	--	--	--	--
rs149508256^1,2	C	--	57174011(+)	`AACTGC/TACTTT`	5	--	ds500¹ int¹		0	--	--	--	--
rs74457171^1,2	C,F	--	57174264(+)	`GGGTTC/ACTGCC`	5	--	ds500¹ int¹		2		CSA WA	119
rs144181508^1,2		--	57174280(+)	`TCTGGA/GTCCAG`	5	--	ds500¹ int¹		0	--	--	--	--
rs150911190^1,2	C	--	57174320(+)	`TACCC-/TCTTCTCA`	5	--	cds¹		0	--	--	--	--
rs149030413^1,2	C	--	57174368(+)	`CACAA-/ACACACA`	5	--	ds500¹ int¹		0	--	--	--	--
rs112820568^1,2	C,F	--	57174395(+)	`AGCCCC/AGGCCC`	5	--	ds500¹ int¹		2		CSA WA	119
rs192732815^1,2		--	57174396(+)	`GCCCCA/GGCCCA`	5	--	ds500¹ int¹		0	--	--	--	--
rs184707900^1,2		--	57174475(+)	`CGAGAC/GAAATT`	5	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC43A3 (57174427 - 57195053 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for SLC43A3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC43A3

DNA2.0 Custom Variant and Variant Library Synthesis for SLC43A3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC43A3 for disorders About GeneDecksing

2 diseases for SLC43A3: About MalaCards

crohn's disease

Genetic Association Database (GAD): SLC43A3

Export disorders for SLC43A3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC43A3 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with SLC43A3)

Utopia: connect your pdf to the dynamic
world of online information

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)^{1, 4} Kenny E.E....Peter I. (2012)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis. (PubMed id 11704567)^{1, 3} Stuart R.O....Nigam S.K. (2001)
Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. (PubMed id 7531438)^{1, 3} Li M.S.... Spry C.J. (1995)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (2012)
Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)¹ Wang J....Yang X. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 29015	HGNC: 17466	AceView: PRG2andSLC43A3	Ensembl:ENSG00000134802	euGenes: HUgn29015
ECgene: SLC43A3	H-InvDB: SLC43A3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC43A3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC43A3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC43A3 gene:
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SLC43A3 Gene

Solute Carrier Family 43, Member 3

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SLC43A3 Gene

Solute Carrier Family 43, Member 3

Aliasesfor SLC43A3 gene

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