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Aliases for SLC43A3 Gene

Aliases for SLC43A3 Gene

  • Solute Carrier Family 43 Member 3 2 3 5
  • Likely Ortholog Of Mouse Embryonic Epithelial Gene 1 2 3
  • Solute Carrier Family 43, Member 3 2
  • Protein FOAP-13 4
  • FOAP-13 3
  • PRO1659 3
  • SEEEG-1 3
  • EEG1 3

External Ids for SLC43A3 Gene

Previous GeneCards Identifiers for SLC43A3 Gene

  • GC11M056950
  • GC11M056931
  • GC11M057174
  • GC11M053523

Summaries for SLC43A3 Gene

GeneCards Summary for SLC43A3 Gene

SLC43A3 (Solute Carrier Family 43 Member 3) is a Protein Coding gene. An important paralog of this gene is SLC43A2.

UniProtKB/Swiss-Prot for SLC43A3 Gene

  • Putative transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC43A3 Gene

Genomics for SLC43A3 Gene

Regulatory Elements for SLC43A3 Gene

Enhancers for SLC43A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F057405 1.5 FANTOM5 Ensembl ENCODE 23.7 +20.9 20902 2.6 PKNOX1 ESRRA MXI1 JUN MAX EBF1 RELA POLR2A ADNP EED SLC43A3 P2RX3 RN7SKP259 RTN4RL2 SSRP1 PRG2 TIMM10 UBE2L6 ZDHHC5 GC11M057408
GH11F057557 0.5 FANTOM5 12.5 -129.6 -129591 0.2 ZFHX2 POLR2A ZBTB11 GLIS1 KLF9 KLF4 KDM1A ZBTB7A EGR2 SERPING1 SLC43A3 TIMM10 MIR130A SLC43A1 ENSG00000254979 UBE2L6 SMTNL1
GH11F057353 0.9 Ensembl ENCODE 11.7 +73.1 73080 1.4 HDAC1 PKNOX1 ESRRA NR2F1 ZBTB11 DPF2 GABPA SMARCA4 ZNF512 NR2F6 ENSG00000254979 SLC43A3 PRG2 ENSG00000254662 TNKS1BP1 BTBD18 CTNND1 P2RX3 PRG3
GH11F057356 0.9 Ensembl 11.7 +71.2 71180 0.4 PKNOX1 ATF3 YY1 ENSG00000254979 SLC43A3 PRG2 ENSG00000254662 TNKS1BP1 BTBD18 CTNND1 P2RX3 PRG3
GH11F057354 0.2 ENCODE 11.7 +74.0 73952 0.1 ZBTB11 NR2C2 ENSG00000254979 SLC43A3 PRG2 ENSG00000254662 TNKS1BP1 BTBD18 CTNND1 P2RX3 PRG3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC43A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC43A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001570388 680 1001 HDGF TBP CREB3L1 WRNIP1 NFRKB RAD21 ZBTB40 YY1 EGR1 ETV6

Genomic Location for SLC43A3 Gene

Chromosome:
11
Start:
57,406,954 bp from pter
End:
57,427,580 bp from pter
Size:
20,627 bases
Orientation:
Minus strand

Genomic View for SLC43A3 Gene

Genes around SLC43A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC43A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC43A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC43A3 Gene

Proteins for SLC43A3 Gene

  • Protein details for SLC43A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBI5-S43A3_HUMAN
    Recommended name:
    Solute carrier family 43 member 3
    Protein Accession:
    Q8NBI5
    Secondary Accessions:
    • B4DNR8
    • E7EQD2
    • Q9NSS4

    Protein attributes for SLC43A3 Gene

    Size:
    491 amino acids
    Molecular mass:
    54529 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC43A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC43A3 Gene

Post-translational modifications for SLC43A3 Gene

  • Ubiquitination at Lys 249 and Lys 255
  • Glycosylation at Asn 56, Asn 220, and Asn 229
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for SLC43A3
  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC43A3

No data available for DME Specific Peptides for SLC43A3 Gene

Domains & Families for SLC43A3 Gene

Gene Families for SLC43A3 Gene

HGNC:
IUPHAR :

Protein Domains for SLC43A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC43A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBI5

UniProtKB/Swiss-Prot:

S43A3_HUMAN :
  • Belongs to the SLC43A transporter (TC 2.A.1.44) family.
Family:
  • Belongs to the SLC43A transporter (TC 2.A.1.44) family.
genes like me logo Genes that share domains with SLC43A3: view

Function for SLC43A3 Gene

Molecular function for SLC43A3 Gene

UniProtKB/Swiss-Prot Function:
Putative transporter.

Gene Ontology (GO) - Molecular Function for SLC43A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SLC43A3: view
genes like me logo Genes that share phenotypes with SLC43A3: view

Animal Model Products

miRNA for SLC43A3 Gene

miRTarBase miRNAs that target SLC43A3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC43A3 Gene

Localization for SLC43A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC43A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC43A3 Gene COMPARTMENTS Subcellular localization image for SLC43A3 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC43A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC43A3: view

Pathways & Interactions for SLC43A3 Gene

SuperPathways for SLC43A3 Gene

No Data Available

Interacting Proteins for SLC43A3 Gene

Gene Ontology (GO) - Biological Process for SLC43A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC43A3: view

No data available for Pathways by source and SIGNOR curated interactions for SLC43A3 Gene

Transcripts for SLC43A3 Gene

Unigene Clusters for SLC43A3 Gene

Solute carrier family 43, member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC43A3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: -
SP5:
SP6: - - - -
SP7: - - - - - -
SP8: -
SP9: - - -
SP10: - - - - - - -
SP11: - - - -
SP12: - - - - - - - -
SP13: - - - - -
SP14: - - - - - -
SP15: - - - - -
SP16: - - - - - -
SP17: - - -
SP18: - - - - - -

ExUns: 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for SLC43A3 Gene

GeneLoc Exon Structure for
SLC43A3
ECgene alternative splicing isoforms for
SLC43A3

Expression for SLC43A3 Gene

mRNA expression in normal human tissues for SLC43A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC43A3 Gene

This gene is overexpressed in Liver (x5.4).

Protein differential expression in normal tissues from HIPED for SLC43A3 Gene

This gene is overexpressed in Urine (31.6) and Breast (23.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC43A3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC43A3 Gene:

SLC43A3

SOURCE GeneReport for Unigene cluster for SLC43A3 Gene:

Hs.99962

mRNA Expression by UniProt/SwissProt for SLC43A3 Gene:

Q8NBI5-S43A3_HUMAN
Tissue specificity: Highly expressed in macrophages.
genes like me logo Genes that share expression patterns with SLC43A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for SLC43A3 Gene

Orthologs for SLC43A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC43A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC43A3 34 35
  • 95.93 (n)
dog
(Canis familiaris)
Mammalia SLC43A3 34 35
  • 84.01 (n)
cow
(Bos Taurus)
Mammalia SLC43A3 34 35
  • 82.17 (n)
mouse
(Mus musculus)
Mammalia Slc43a3 34 16 35
  • 79.49 (n)
rat
(Rattus norvegicus)
Mammalia Slc43a3 34
  • 79.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC43A3 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC43A3 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC43A3 34 35
  • 65.96 (n)
lizard
(Anolis carolinensis)
Reptilia SLC43A3 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc43a3b 34 35
  • 61.12 (n)
slc43a3a 35
  • 52 (a)
OneToMany
Dr.26648 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMR221C 34
  • 44.85 (n)
-- 35
  • 19 (a)
OneToMany
FMP42 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07040g 34
  • 40.14 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10987 34
  • 44.44 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
-- 35
  • 30 (a)
OneToMany
-- 35
  • 29 (a)
OneToMany
-- 35
  • 27 (a)
OneToMany
Species where no ortholog for SLC43A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC43A3 Gene

ENSEMBL:
Gene Tree for SLC43A3 (if available)
TreeFam:
Gene Tree for SLC43A3 (if available)

Paralogs for SLC43A3 Gene

Variants for SLC43A3 Gene

Sequence variations from dbSNP and Humsavar for SLC43A3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1049272 -- 57,407,157(-) TGTCC(G/T)AGAAG utr-variant-3-prime
rs1049273 -- 57,407,111(-) GGGCC(A/G)TGGGA utr-variant-3-prime
rs10750861 -- 57,413,934(+) ccatt(C/T)cctcc intron-variant
rs10750862 -- 57,414,190(+) tgaat(G/T)aatGA intron-variant
rs111254674 -- 57,416,077(+) TTTTG(-/T)CCTTC intron-variant

Variation tolerance for SLC43A3 Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC43A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC43A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC43A3 Gene

Disorders for SLC43A3 Gene

Relevant External Links for SLC43A3

Genetic Association Database (GAD)
SLC43A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC43A3

No disorders were found for SLC43A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC43A3 Gene

Publications for SLC43A3 Gene

  1. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 3 46 64
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  3. EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis. (PMID: 11704567) Stuart R.O. … Nigam S.K. (Am. J. Physiol. Renal Physiol. 2001) 2 3 64
  4. Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. (PMID: 7531438) Li M.S. … Spry C.J. (Biochem. J. 1995) 2 3 64
  5. Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals. (PMID: 26455426) Furukawa J. … Yuasa H. (Sci Rep 2015) 3 64

Products for SLC43A3 Gene

Sources for SLC43A3 Gene

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