Set Analyses:
GeneALaCart
GeneDecks
VarElect
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 


SLC43A3 Gene

protein-coding   GIFtS: 49
GCID: GC11M057174

Solute Carrier Family 43, Member 3
  See related disease
at
MalaCards
 

Aliases
for SLC43A3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus
Aliases
Solute Carrier Family 43, Member 31 2     PRO16592
Likely Ortholog Of Mouse Embryonic Epithelial Gene 11 2     SEEEG-12
EEG12     Solute Carrier Family 43 Member 32
FOAP-132     Protein FOAP-133

External Ids:    HGNC: 174661   Entrez Gene: 290152   Ensembl: ENSG000001348027   UniProtKB: Q8NBI53   

Export aliases for SLC43A3 gene to outside databases

Previous GC identifers: GC11M056950 GC11M056931 GC11M053523


Summaries
for SLC43A3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus
GeneCards Summary for SLC43A3 Gene:
SLC43A3 (solute carrier family 43, member 3) is a protein-coding gene. Diseases associated with SLC43A3 include crohn's disease. An important paralog of this gene is SLC43A2.

UniProtKB/Swiss-Prot: S43A3_HUMAN, Q8NBI5
Function: Putative transporter (By similarity)




Genomic Views
for SLC43A3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC43A3 gene promoter:
         HFH-3   FOXI1   NRF-2   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SLC43A3 promoter sequence
   Search Chromatin IP Primers for SLC43A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC43A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q11

SLC43A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC43A3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057174:  view genomic region     (about GC identifiers)

Start:
 57,174,427 bp from pter      End:
 57,195,053 bp from pter
Size:
 20,627 bases      Orientation:
 minus strand

Proteins
for SLC43A3 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus
UniProtKB/Swiss-Prot: S43A3_HUMAN, Q8NBI5 (See protein sequence)
Recommended Name: Solute carrier family 43 member 3  
Size: 491 amino acids; 54529 Da
Secondary accessions: Q9NSS4

Explore the universe of human proteins at neXtProt for SLC43A3: NX_Q8NBI5

Explore proteomics data for SLC43A3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys249, Lys255, Lys264
  • Glycosylation2 at Asn56, Asn220, Asn229
  • Modification sites at PhosphoSitePlus

    • See SLC43A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001265130.1  NP_001265135.1  NP_054815.2  NP_060081.1  NP_955361.1  

    ENSEMBL proteins: 
     ENSP00000378555   ENSP00000378556   ENSP00000337561   ENSP00000436254   ENSP00000433078  
     ENSP00000434515   ENSP00000435893   ENSP00000434293   ENSP00000436055   ENSP00000434913  
     ENSP00000435273   ENSP00000433974   ENSP00000431762   ENSP00000435156   ENSP00000434569  
     ENSP00000435109   ENSP00000435490   ENSP00000431367   ENSP00000434710   ENSP00000431765  
     ENSP00000433393   ENSP00000434371  

    SLC43A3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC43A3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC43A3
    GenScript Custom Purified and Recombinant Proteins Services for SLC43A3
    Novus Biologicals SLC43A3 Protein
    Novus Biologicals SLC43A3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC43A3

    SLC43A3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC43A3
    Novus Biologicals SLC43A3 Antibodies
    Abcam antibodies for SLC43A3
    Cloud-Clone Corp. Antibodies for SLC43A3
    Search ThermoFisher Antibodies for SLC43A3
    LSBio Antibodies in human, mouse, rat for SLC43A3

    SLC43A3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC43A3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC43A3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLC43A3
    Cloud-Clone Corp. CLIAs for SLC43A3

    Domains /
    Families
    for SLC43A3 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: EEG1
    SLC43 family of large neutral amino acid transporters

    4 InterPro protein domains:
     IPR011701 MFS
     IPR027197 SLC43A3
     IPR016196 MFS_dom_general_subst_transpt
     IPR027192 SLC43_2/3

    Graphical View of Domain Structure for InterPro Entry Q8NBI5

    ProtoNet protein and cluster: Q8NBI5

    UniProtKB/Swiss-Prot: S43A3_HUMAN, Q8NBI5
    Similarity: Belongs to the SLC43A transporter (TC 2.A.1.44) family


    SLC43A3 for domains           About GeneDecksing


    Function
    for SLC43A3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S43A3_HUMAN, Q8NBI5
    Function: Putative transporter (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    SLC43A3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC43A3:
     Decreased viability with cispl  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC43A3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC43A3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC43A3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC43A3

    miRNA
    Products:            		miRTarBase miRNAs that target SLC43A3:
    hsa-mir-124-3p (MIRT022191)

    Block miRNA regulation of human, mouse, rat SLC43A3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SLC43A3:
    hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmid: SLC43A3 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for SLC43A3
    Predesigned siRNA for gene silencing in human, mouse, rat SLC43A3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SLC43A3

    Clone
    Products:             		 OriGene clones in human, mouse for SLC43A3 (see all 18)
    OriGene ORF clones in mouse, rat for SLC43A3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SLC43A3 (NM_014096)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC43A3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC43A3

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SLC43A3
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC43A3 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC43A3


    Localization
    for SLC43A3 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Subcellular locations from UniProtKB/Swiss-Prot
    S43A3_HUMAN, Q8NBI5: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral component of membrane IEA--

    SLC43A3 for ontologies           About GeneDecksing


    Pathways & Interactions
    for SLC43A3 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC43A3
    Interactions:

        Search GeneGlobe Interaction Network for SLC43A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SLC43A3 (ENSP000003375614) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP6V1HENSP000003525224STRING: ENSP00000352522
    UBCENSP000003448184STRING: ENSP00000344818
    LAMC3ENSP000003543604STRING: ENSP00000354360
    SH3YL1ENSP000004041434STRING: ENSP00000404143
    SLC30A1ENSP000003559684STRING: ENSP00000355968
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0055085transmembrane transport IEA--

    SLC43A3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC43A3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC43A3 (S43A3)



    Transcripts
    for SLC43A3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus
    REFSEQ mRNAs for SLC43A3 gene (5 alternative transcripts): 
    NM_001278201.1  NM_001278206.1  NM_014096.3  NM_017611.2  NM_199329.2  

    Unigene Cluster for SLC43A3:

    Solute carrier family 43, member 3
    Hs.99962  [show with all ESTs]
    Unigene Representative Sequence: NM_014096
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000395123(uc001nkg.3) ENST00000395124(uc001nkh.3 uc010rjr.2 uc009yme.3)
    ENST00000352187(uc001nki.3) ENST00000529554 ENST00000525205 ENST00000533524(uc009ymg.1)
    ENST00000530005(uc009ymf.1) ENST00000528098(uc010rjs.1) ENST00000529113
    ENST00000525474 ENST00000529112 ENST00000526125 ENST00000530232 ENST00000528187
    ENST00000529494 ENST00000533245 ENST00000533235 ENST00000524863
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat SLC43A3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SLC43A3:
    hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmid: SLC43A3 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for SLC43A3
    Predesigned siRNA for gene silencing in human, mouse, rat SLC43A3
    Clone
    Products:             		 OriGene clones in human, mouse for SLC43A3 (see all 18)
    OriGene ORF clones in mouse, rat for SLC43A3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SLC43A3 (NM_014096)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC43A3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC43A3
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for SLC43A3
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC43A3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC43A3
      QuantiTect SYBR Green Assays in human, mouse, rat SLC43A3
      QuantiFast Probe-based Assays in human, mouse, rat SLC43A3

    Additional mRNA sequence: 

    AB028927.1 AF118070.1 AK075552.1 AK290391.1 AK298028.1 AK300977.1 AK311394.1 AK311401.1 
    AK315839.1 AL157431.1 BC003163.1 CR457391.1 

    21 DOTS entries:

    DT.97767574  DT.75134243  DT.100654796  DT.99948191  DT.100654800  DT.95194818  DT.95194802  DT.95194809 
    DT.100654797  DT.100697572  DT.92394980  DT.95194816  DT.100660307  DT.91771616  DT.100042068  DT.100803256 
    DT.120728564  DT.95188227  DT.95194804  DT.97862181  DT.121441976 

    Selected AceView cDNA sequences (see all 873):

    AA344226 CR591196 CR590243 CR610568 CR619867 CR624849 CB120199 NM_014096 
    CR617394 BM988367 CA419841 AA196603 CR611197 CR615431 CR602195 CR601470 
    CR614707 CF127273 BF058520 CR605831 BU624342 CR591375 CR617406 NM_199329 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC43A3 (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^
    SP1:        -     -     -     -     -     -           -                                         -                                                               
    SP2:                          -     -     -           -                                         -                                                               
    SP3:                          -     -     -           -                 -     -                 -                                                               
    SP4:                                                                                            -                                                               
    SP5:                                                                                                                                                            

    ExUns: 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:  -                                                   
    SP2:  -                                                   
    SP3:                                                      
    SP4:                                                      
    SP5:                                      -               


    ECgene alternative splicing isoforms for SLC43A3

    Expression
    for SLC43A3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC43A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCCAGCT
    SLC43A3 Expression
    About this image

    SLC43A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    SLC43A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.99962

    UniProtKB/Swiss-Prot: S43A3_HUMAN, Q8NBI5
    Tissue specificity: Highly expressed in macrophages

        Custom PCR Arrays for SLC43A3
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for SLC43A3
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC43A3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC43A3
    QuantiTect SYBR Green Assays in human, mouse, rat SLC43A3
    QuantiFast Probe-based Assays in human, mouse, rat SLC43A3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC43A3

    Orthologs
    for SLC43A3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC43A3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Slc43a31 , 5 solute carrier family 43, member 31, 5 79.49(n)1
    76.54(a)1    		   2 (49.45 cM)5
    582071  NM_021398.31  NP_067373.21 
     849365795 
    chicken
    (Gallus gallus)    		 Aves SLC43A31 solute carrier family 43, member 3 65.96(n)
    58.3(a)    		   423133  XM_003641377.2  XP_003641425.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC43A36
    		 solute carrier family 43, member 3
    		 52(a)
    		 1 ↔ 1
    		 1(92028910-92066967)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.266482 Danio rerio cDNA clone IMAGE3820673, partial cds 73.83(n)    BC054919.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes (YMR221C)4
    YMR221C1    		 Putative protein of unknown function; the authentic, more4
    YMR221C1    		 44.85(n)1
    35.15(a)1    		   13(715445-713931)4
    8552611, 4  NP_013948.11, 4 


    ENSEMBL Gene Tree for SLC43A3 (if available)
    TreeFam Gene Tree for SLC43A3 (if available)

    Paralogs
    for SLC43A3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC43A3 gene
    SLC43A22  SLC43A12  
    2 SIMAP similar genes for SLC43A3 using alignment to 18 protein entries:     S43A3_HUMAN (see all proteins):
    SLC43A1    SLC43A2

    SLC43A3 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC43A3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Selected SNPs for SLC43A3 (see all 563)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1872742141,2
    		--57173958(+) GCAGTG/TGCAAT 5 -- ds5001 int10--------
    rs1380591691,2
    		--57174004(+) AATGAC/TTAACT 5 -- ds5001 int10--------
    rs1495082561,2
    		C--57174011(+) AACTGC/TACTTT 5 -- ds5001 int10--------
    rs744571711,2
    		C,F--57174264(+) GGGTTC/ACTGCC 5 -- ds5001 int12Minor allele frequency- A:0.10CSA WA 119
    rs1441815081,2
    		--57174280(+) TCTGGA/GTCCAG 5 -- ds5001 int10--------
    rs1509111901,2
    		C--57174320(+) TACCC-/TCTTCTCA 5 -- cds10--------
    rs1490304131,2
    		C--57174368(+) CACAA-/ACACACA 5 -- ds5001 int10--------
    rs1128205681,2
    		C,F--57174395(+) AGCCCC/AGGCCC 5 -- ds5001 int12Minor allele frequency- A:0.15CSA WA 119
    rs1927328151,2
    		--57174396(+) GCCCCA/GGCCCA 5 -- ds5001 int10--------
    rs1847079001,2
    		--57174475(+) CGAGAC/GAAATT 5 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC43A3 (57174427 - 57195053 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC43A3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC43A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC43A3

    Disorders / Diseases
    for SLC43A3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 1 disease for SLC43A3:    About MalaCards
    crohn's disease


    SLC43A3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC43A3

    Export disorders for SLC43A3 gene to outside databases

    Publications
    for SLC43A3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus
    PubMed articles for SLC43A3 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with SLC43A3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1, 4 Kenny E.E....Peter I. (PLoS Genet. 2012)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis. (PubMed id 11704567)1, 3 Stuart R.O....Nigam S.K. (Am. J. Physiol. Renal Physiol. 2001)
    4. Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. (PubMed id 7531438)1, 3 Li M.S.... Spry C.J. (Biochem. J. 1995)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)

    External Searches for SLC43A3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC43A3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29015 HGNC: 17466 AceView: PRG2andSLC43A3 Ensembl:ENSG00000134802 euGenes: HUgn29015
    ECgene: SLC43A3 H-InvDB: SLC43A3

    Other Databases showing SLC43A3 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing SLC43A3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC43A3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC43A3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for SLC43A3 gene:
    Search GeneIP for patents involving SLC43A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SLC43A3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC43A3  
     OriGene qPCR primer pairs and template standards for SLC43A3   OriGene Protein Over-expression Lysate for SLC43A3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC43A3  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC43A3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC43A3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC43A3   OriGene Custom Protein Services for SLC43A3  

         		 
     Block miRNA regulation of human, mouse, rat SLC43A3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC43A3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC43A3 Predesigned siRNA for gene silencing in human, mouse, rat SLC43A3
     QuantiFast Probe-based Assays in human, mouse, rat SLC43A3 QuantiTect SYBR Green Assays in human, mouse, rat SLC43A3
     Custom PCR Arrays for SLC43A3 Search Chromatin IP Primers for SLC43A3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC43A3  Search GeneGlobe Interaction Network for SLC43A3
     Regulatory tfbs in SLC43A3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC43A3 GenScript cDNA clones with any tag delivered in your preferred vector for SLC43A3
     GenScript Custom Assay Services for SLC43A3 GenScript Custom overexpressing Cell Line Services for SLC43A3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC43A3 (S43A3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC43A3 antibodies
     SLC43A3 proteins
     SLC43A3 lysates
     Antibodies for SLC43A3
     See all of Abcam's Antibodies, Kits and Proteins for SLC43A3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SLC43A3
     Antibodies for SLC43A3
     ELISAs for SLC43A3
     CLIAs for SLC43A3



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC43A3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC43A3
     SwitchGear 3'UTR luciferase reporter plasmids for SLC43A3
     SwitchGear Promoter luciferase reporter plasmids for SLC43A3
     Search ThermoFisher Antibodies for SLC43A3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC43A3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC43A3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC43A3
     LSBio Antibodies in human, mouse, rat for SLC43A3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SLC43A3 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4