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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC43A3 Gene

protein-coding   GIFtS: 47
GCID: GC11M057174

Solute Carrier Family 43, Member 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 43, Member 31 2     PRO16592
Likely Ortholog Of Mouse Embryonic Epithelial Gene 11 2     SEEEG-12
EEG12     Solute Carrier Family 43 Member 32
FOAP-132     Protein FOAP-133

External Ids:    HGNC: 174661   Entrez Gene: 290152   Ensembl: ENSG000001348027   UniProtKB: Q8NBI53   

Export aliases for SLC43A3 gene to outside databases

Previous GC identifers: GC11M056950 GC11M056931 GC11M053523


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC43A3 Gene: 
SLC43A3 (solute carrier family 43, member 3) is a protein-coding gene. Diseases associated with SLC43A3 include crohn's disease. An important paralog of this gene is SLC43A2.

UniProtKB/Swiss-Prot: S43A3_HUMAN, Q8NBI5
Function: Putative transporter (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC43A3 gene promoter:
         HFH-3   FOXI1   NRF-2   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SLC43A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC43A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC43A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q11

SLC43A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC43A3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057174:  view genomic region     (about GC identifiers)

Start:
57,174,427 bp from pter      End:
57,195,053 bp from pter
Size:
20,627 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S43A3_HUMAN, Q8NBI5 (See protein sequence)
Recommended Name: Solute carrier family 43 member 3  
Size: 491 amino acids; 54529 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q9NSS4

Explore the universe of human proteins at neXtProt for SLC43A3: NX_Q8NBI5

Explore proteomics data for SLC43A3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NBI5

  • SLC43A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC43A3 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001265130.1  NP_001265135.1  NP_054815.2  NP_060081.1  NP_955361.1  

    ENSEMBL proteins: 
     ENSP00000378555   ENSP00000378556   ENSP00000337561   ENSP00000436254   ENSP00000433078  
     ENSP00000434515   ENSP00000435893   ENSP00000434293   ENSP00000436055   ENSP00000434913  
     ENSP00000435273   ENSP00000433974   ENSP00000431762   ENSP00000435156   ENSP00000434569  
     ENSP00000435109   ENSP00000435490   ENSP00000431367   ENSP00000434710   ENSP00000431765  
     ENSP00000433393   ENSP00000434371  

    Human Recombinant Protein Products for SLC43A3: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC43A3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    SLC43A3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: EEG1 
    SLC43 family of large neutral amino acid transporters

    4 InterPro protein domains:
     IPR027197 SLC43A3
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt
     IPR027192 SLC43

    Graphical View of Domain Structure for InterPro Entry Q8NBI5

    ProtoNet protein and cluster: Q8NBI5

    UniProtKB/Swiss-Prot: S43A3_HUMAN, Q8NBI5
    Similarity: Belongs to the SLC43A transporter (TC 2.A.1.44) family


    SLC43A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S43A3_HUMAN, Q8NBI5
    Function: Putative transporter (By similarity)

    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC43A3:

     Decreased viability with cispl  Synthetic lethal with c-Myc af 

    Animal Models:
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    hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidSLC43A3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC43A3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC43A3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SLC43A3 (ENSP000003375614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    LAMC3ENSP000003543604STRING: ENSP00000354360
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055085transmembrane transport IEA--

    SLC43A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC43A3 (S43A3)

    Search CenterWatch for drugs/clinical trials and news about SLC43A3 / S43A3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC43A3 gene (5 alternative transcripts): 
    NM_001278201.1  NM_001278206.1  NM_014096.3  NM_017611.2  NM_199329.2  

    Unigene Cluster for SLC43A3:

    Solute carrier family 43, member 3
    Hs.99962  [show with all ESTs]
    Unigene Representative Sequence: NM_014096
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000395123(uc001nkg.3) ENST00000395124(uc001nkh.3 uc010rjr.2 uc009yme.3)
    ENST00000352187(uc001nki.3) ENST00000529554 ENST00000525205 ENST00000533524(uc009ymg.1)
    ENST00000530005(uc009ymf.1) ENST00000528098(uc010rjs.1) ENST00000529113
    ENST00000525474 ENST00000529112 ENST00000526125 ENST00000530232 ENST00000528187
    ENST00000529494 ENST00000533245 ENST00000533235 ENST00000524863
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SLC43A3:
    hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidSLC43A3 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC43A3
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    Additional mRNA sequence: 

    AB028927.1 AF118070.1 AK075552.1 AK290391.1 AK298028.1 AK300977.1 AK311394.1 AK311401.1 
    AK315839.1 AL157431.1 BC003163.1 CR457391.1 

    21 DOTS entries:

    DT.97767574  DT.75134243  DT.100654796  DT.99948191  DT.100654800  DT.95194818  DT.95194802  DT.95194809 
    DT.100654797  DT.100697572  DT.92394980  DT.95194816  DT.100660307  DT.91771616  DT.100042068  DT.100803256 
    DT.120728564  DT.95188227  DT.95194804  DT.97862181  DT.121441976 

    24/873 AceView cDNA sequences (see all 873):

    C17720 CR606261 CR618388 BU624342 CR618883 CR599398 AW779414 AA286984 
    CR603683 CR590778 CR622244 CA310160 CR600307 BU628614 CR597111 AA284125 
    CR603205 NM_017611 CR624403 BM455796 BQ446791 CR593939 CR615951 AI074500 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for SLC43A3 (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^
    SP1:        -     -     -     -     -     -           -                                         -                                                               
    SP2:                          -     -     -           -                                         -                                                               
    SP3:                          -     -     -           -                 -     -                 -                                                               
    SP4:                                                                                            -                                                               
    SP5:                                                                                                                                                            

    ExUns: 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:  -                                                   
    SP2:  -                                                   
    SP3:                                                      
    SP4:                                                      
    SP5:                                      -               


    ECgene alternative splicing isoforms for SLC43A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC43A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCCAGCT
    SLC43A3 Expression
    About this image


    See SLC43A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC43A3

    SOURCE GeneReport for Unigene cluster: Hs.99962

    UniProtKB/Swiss-Prot: S43A3_HUMAN, Q8NBI5
    Tissue specificity: Highly expressed in macrophages

        SABiosciences Custom PCR Arrays for SLC43A3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC43A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC43A3 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc43a31 , 5 solute carrier family 43, member 31, 5 79.49(n)1
    76.54(a)1
      2 (49.45 cM)5
    582071  NM_021398.31  NP_067373.21 
     849365795 
    chicken
    (Gallus gallus)
    Aves SLC43A31 solute carrier family 43, member 3 65.46(n)
    57.87(a)
      423133  XM_003641377.1  XP_003641425.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC43A36
    solute carrier family 43, member 3
    50(a)
    1 ↔ 1
    1(92028910-92066967)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.266482 Danio rerio cDNA clone IMAGE3820673, partial cds 73.83(n)    BC054919.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YMR221C)4
    YMR221C1
    Putative protein of unknown function; the authentic, more4
    hypothetical protein1
    38.54(n)1
    24.94(a)1
      13(715445-713931)4
    8552611, 4  NP_013948.11, 4 


    ENSEMBL Gene Tree for SLC43A3 (if available)
    TreeFam Gene Tree for SLC43A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC43A3 gene
    SLC43A22  SLC43A12  
    2 SIMAP similar genes for SLC43A3 using alignment to 18 protein entries:     S43A3_HUMAN (see all proteins):
    SLC43A1    SLC43A2

    SLC43A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/563 SNPs in SLC43A3 are shown (see all 563)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872742141,2
    --57173958(+) GCAGTG/TGCAAT 5 -- ds5001 int10--------
    rs1380591691,2
    --57174004(+) AATGAC/TTAACT 5 -- ds5001 int10--------
    rs1495082561,2
    C--57174011(+) AACTGC/TACTTT 5 -- ds5001 int10--------
    rs744571711,2
    C,F--57174264(+) GGGTTC/ACTGCC 5 -- ds5001 int12Minor allele frequency- A:0.10CSA WA 119
    rs1441815081,2
    --57174280(+) TCTGGA/GTCCAG 5 -- ds5001 int10--------
    rs1509111901,2
    C--57174320(+) TACCC-/TCTTCTCA 5 -- cds10--------
    rs1490304131,2
    C--57174368(+) CACAA-/ACACACA 5 -- ds5001 int10--------
    rs1128205681,2
    C,F--57174395(+) AGCCCC/AGGCCC 5 -- ds5001 int12Minor allele frequency- A:0.15CSA WA 119
    rs1927328151,2
    --57174396(+) GCCCCA/GGCCCA 5 -- ds5001 int10--------
    rs1847079001,2
    --57174475(+) CGAGAC/GAAATT 5 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC43A3 (57174427 - 57195053 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC43A3: --
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SLC43A3:    About MalaCards
    crohn's disease    


    SLC43A3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC43A3

    Export disorders for SLC43A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC43A3 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SLC43A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1, 4 Kenny E.E....Peter I. (2012)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    3. EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis. (PubMed id 11704567)1, 3 Stuart R.O....Nigam S.K. (2001)
    4. Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. (PubMed id 7531438)1, 3 Li M.S.... Spry C.J. (1995)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29015 HGNC: 17466 AceView: PRG2andSLC43A3 Ensembl:ENSG00000134802 euGenes: HUgn29015
    ECgene: SLC43A3 H-InvDB: SLC43A3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC43A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC43A3 gene:
    Search GeneIP for patents involving SLC43A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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