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Aliases for SLC43A2 Gene

Aliases for SLC43A2 Gene

  • Solute Carrier Family 43 (Amino Acid System L Transporter), Member 2 2 3
  • LAT4 3 4 6
  • L-Type Amino Acid Transporter 4 3 4
  • Large Neutral Amino Acids Transporter Small Subunit 4 3
  • Solute Carrier Family 43, Member 2 3
  • Solute Carrier Family 43 Member 2 4
  • Amino Acid Transporter 3

External Ids for SLC43A2 Gene

Summaries for SLC43A2 Gene

Entrez Gene Summary for SLC43A2 Gene

  • System L amino acid transporters, such as SLC43A2, mediate sodium-independent transport of bulky neutral amino acids across cell membranes (Bodoy et al., 2005 [PubMed 15659399]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC43A2 Gene

SLC43A2 (Solute Carrier Family 43 (Amino Acid System L Transporter), Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include L-amino acid transmembrane transporter activity. An important paralog of this gene is SLC43A1.

UniProtKB/Swiss-Prot for SLC43A2 Gene

  • Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC43A2 Gene

Genomics for SLC43A2 Gene

Genomic Location for SLC43A2 Gene

Start:
1,569,254 bp from pter
End:
1,629,985 bp from pter
Size:
60,732 bases
Orientation:
Minus strand

Genomic View for SLC43A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC43A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC43A2 Gene

Regulatory Elements for SLC43A2 Gene

Proteins for SLC43A2 Gene

  • Protein details for SLC43A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N370-LAT4_HUMAN
    Recommended name:
    Large neutral amino acids transporter small subunit 4
    Protein Accession:
    Q8N370
    Secondary Accessions:
    • B7Z6X9
    • C9JNU8
    • D3DTH9
    • Q5CD75
    • Q6IPM1
    • Q8NBX1
    • Q8NC21
    • Q8WZ00

    Protein attributes for SLC43A2 Gene

    Size:
    569 amino acids
    Molecular mass:
    62747 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11383.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11450.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC43A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC43A2 Gene

Proteomics data for SLC43A2 Gene at MOPED

Post-translational modifications for SLC43A2 Gene

Other Protein References for SLC43A2 Gene

No data available for DME Specific Peptides for SLC43A2 Gene

Domains for SLC43A2 Gene

Gene Families for SLC43A2 Gene

Protein Domains for SLC43A2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

LAT4_HUMAN
Family:
  • Belongs to the SLC43A transporter (TC 2.A.1.44) family.:
    • Q8N370
genes like me logo Genes that share domains with SLC43A2: view

Function for SLC43A2 Gene

Molecular function for SLC43A2 Gene

UniProtKB/Swiss-Prot Function: Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids.

Gene Ontology (GO) - Molecular Function for SLC43A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015179 L-amino acid transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC43A2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC43A2 Gene

Localization for SLC43A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC43A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC43A2 Gene COMPARTMENTS Subcellular localization image for SLC43A2 gene
Compartment Confidence
plasma membrane 4
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC43A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC43A2: view

Pathways for SLC43A2 Gene

genes like me logo Genes that share pathways with SLC43A2: view

Interacting Proteins for SLC43A2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000301335%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000375478%0d%0a
Selected Interacting proteins: ENSP00000301335 for SLC43A2 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC43A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006865 amino acid transport TAS --
GO:0015807 L-amino acid transport --
GO:0055085 transmembrane transport TAS --
GO:1902475 L-alpha-amino acid transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC43A2: view

Compounds for SLC43A2 Gene

(2) HMDB Compounds for SLC43A2 Gene

Compound Synonyms Cas Number PubMed IDs
Chlorine
  • Cl2
16887-00-6
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with SLC43A2: view

Transcripts for SLC43A2 Gene

mRNA/cDNA for SLC43A2 Gene

(7) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC43A2 Gene

Solute carrier family 43, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC43A2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14a ·
SP1: - - - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6:
SP7:
SP8: - - - - -
SP9:
SP10:
SP11: - - - - -
SP12: -
SP13:
SP14:

ExUns: 14b · 14c ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9: - -
SP10: -
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SLC43A2 Gene

GeneLoc Exon Structure for
SLC43A2
ECgene alternative splicing isoforms for
SLC43A2

Expression for SLC43A2 Gene

mRNA expression in normal human tissues for SLC43A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC43A2 Gene

This gene is overexpressed in Whole Blood (12.7) and Muscle - Skeletal (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC43A2 Gene

SOURCE GeneReport for Unigene cluster for SLC43A2 Gene Hs.160550

mRNA Expression by UniProt/SwissProt for SLC43A2 Gene

Q8N370-LAT4_HUMAN
Tissue specificity: Detected in several tissues with higher expression in placenta, kidney and peripheral blood leukocytes. In the kidney, is detected in epithelial cells of the distal tubule and collecting duct. In the intestine, is expressed mainly in crypt cells of the intestinal microvilli and epithelial cells in the base of the villus.
genes like me logo Genes that share expressions with SLC43A2: view

Orthologs for SLC43A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC43A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC43A2 36
  • 97.73 (n)
  • 97.86 (a)
SLC43A2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC43A2 36
  • 91.43 (n)
  • 94.72 (a)
SLC43A2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC43A2 36
  • 89.5 (n)
  • 94.54 (a)
SLC43A2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc43a2 36
  • 87.79 (n)
  • 91.55 (a)
Slc43a2 16
Slc43a2 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC43A2 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC43A2 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc43a2 36
  • 88.38 (n)
  • 93.66 (a)
chicken
(Gallus gallus)
Aves SLC43A2 36
  • 77.22 (n)
  • 85.59 (a)
SLC43A2 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC43A2 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5041 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc43a2 36
  • 72.54 (n)
  • 83.63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11109 36
zebrafish
(Danio rerio)
Actinopterygii slc43a2a 37
  • 77 (a)
OneToMany
slc43a2b 36
  • 72.23 (n)
  • 76.91 (a)
slc43a2b 37
  • 73 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
OneToMany
Species with no ortholog for SLC43A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC43A2 Gene

ENSEMBL:
Gene Tree for SLC43A2 (if available)
TreeFam:
Gene Tree for SLC43A2 (if available)

Paralogs for SLC43A2 Gene

Paralogs for SLC43A2 Gene

Selected SIMAP similar genes for SLC43A2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC43A2: view

Variants for SLC43A2 Gene

Sequence variations from dbSNP and Humsavar for SLC43A2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs876789 -- 1,592,451(-) GAAAG(A/T)TCTTC intron-variant
rs939564 -- 1,628,304(+) GGCAG(C/G)GGCAG utr-variant-5-prime, intron-variant
rs1051820 -- 1,574,767(-) CGAGG(G/T)GTGTG utr-variant-3-prime
rs1051844 -- 1,574,496(-) GCTTA(A/G)AGGGG utr-variant-3-prime
rs1054538 -- 1,626,257(-) TCTCC(C/T)CCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC43A2 Gene

Variant ID Type Subtype PubMed ID
nsv833334 CNV Loss 17160897
nsv907502 CNV Loss 21882294
nsv907506 CNV Loss 21882294
nsv457635 CNV Gain 19166990
dgv3030n71 CNV Loss 21882294
nsv1945 CNV Insertion 18451855
esv1004030 CNV Deletion 20482838
esv2670177 CNV Deletion 23128226
esv2715472 CNV Deletion 23290073
nsv907509 CNV Loss 21882294
nsv907510 CNV Loss 21882294
nsv907511 CNV Loss 21882294
dgv3031n71 CNV Loss 21882294
nsv907513 CNV Loss 21882294
esv2660696 CNV Deletion 23128226
esv2715475 CNV Deletion 23290073
esv2715476 CNV Deletion 23290073
esv2715477 CNV Deletion 23290073
nsv527897 CNV Loss 19592680
nsv907515 CNV Loss 21882294
dgv3032n71 CNV Loss 21882294
nsv516055 CNV Gain+Loss 19592680
nsv907517 CNV Loss 21882294

Relevant External Links for SLC43A2 Gene

HapMap Linkage Disequilibrium report
SLC43A2

Disorders for SLC43A2 Gene

Relevant External Links for SLC43A2

Genetic Association Database (GAD)
SLC43A2
Human Genome Epidemiology (HuGE) Navigator
SLC43A2
genes like me logo Genes that share disorders with SLC43A2: view

No data available for UniProtKB/Swiss-Prot for SLC43A2 Gene

Publications for SLC43A2 Gene

  1. Identification of LAT4, a novel amino acid transporter with system L activity. (PMID: 15659399) Bodoy S. … Bertran J. (J. Biol. Chem. 2005) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  4. The small SLC43 family: facilitator system l amino acid transporters and the orphan EEG1. (PMID: 23268354) Bodoy S. … PalacA-n M. (Mol. Aspects Med. 2013) 2 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SLC43A2 Gene

Sources for SLC43A2 Gene

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