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Aliases for SLC43A2 Gene

Aliases for SLC43A2 Gene

  • Solute Carrier Family 43 Member 2 2 3 4
  • Solute Carrier Family 43 (Amino Acid System L Transporter), Member 2 2 3 5
  • L-Type Amino Acid Transporter 4 3 4
  • LAT4 3 4

External Ids for SLC43A2 Gene

Previous GeneCards Identifiers for SLC43A2 Gene

  • GC17M001426
  • GC17M001477
  • GC17M001472

Summaries for SLC43A2 Gene

Entrez Gene Summary for SLC43A2 Gene

  • This gene encodes a member of the L-amino acid transporter-3 or SLC43 family of transporters. The encoded protein mediates sodium-, chloride-, and pH-independent transport of L-isomers of neutral amino acids, including leucine, phenylalanine, valine and methionine. This protein may contribute to the transfer of amino acids across the placental membrane to the fetus. [provided by RefSeq, Mar 2016]

GeneCards Summary for SLC43A2 Gene

SLC43A2 (Solute Carrier Family 43 Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include L-amino acid transmembrane transporter activity. An important paralog of this gene is ENSG00000254979.

UniProtKB/Swiss-Prot for SLC43A2 Gene

  • Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC43A2 Gene

Genomics for SLC43A2 Gene

Regulatory Elements for SLC43A2 Gene

Enhancers for SLC43A2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC43A2 on UCSC Golden Path with GeneCards custom track

Promoters for SLC43A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC43A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC43A2 Gene

1,569,254 bp from pter
1,630,018 bp from pter
60,765 bases
Minus strand

Genomic View for SLC43A2 Gene

Genes around SLC43A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC43A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC43A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC43A2 Gene

Proteins for SLC43A2 Gene

  • Protein details for SLC43A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Large neutral amino acids transporter small subunit 4
    Protein Accession:
    Secondary Accessions:
    • B7Z6X9
    • C9JNU8
    • D3DTH9
    • Q5CD75
    • Q6IPM1
    • Q8NBX1
    • Q8NC21
    • Q8WZ00

    Protein attributes for SLC43A2 Gene

    569 amino acids
    Molecular mass:
    62747 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11383.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11450.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC43A2 Gene


neXtProt entry for SLC43A2 Gene

Proteomics data for SLC43A2 Gene at MOPED

Post-translational modifications for SLC43A2 Gene

No data available for DME Specific Peptides for SLC43A2 Gene

Domains & Families for SLC43A2 Gene

Gene Families for SLC43A2 Gene

Protein Domains for SLC43A2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLC43A transporter (TC 2.A.1.44) family.
  • Belongs to the SLC43A transporter (TC 2.A.1.44) family.
genes like me logo Genes that share domains with SLC43A2: view

Function for SLC43A2 Gene

Molecular function for SLC43A2 Gene

UniProtKB/Swiss-Prot Function:
Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids.

Gene Ontology (GO) - Molecular Function for SLC43A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015175 neutral amino acid transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC43A2: view
genes like me logo Genes that share phenotypes with SLC43A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC43A2

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC43A2 Gene

Localization for SLC43A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC43A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC43A2 Gene COMPARTMENTS Subcellular localization image for SLC43A2 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for SLC43A2 Gene

Pathways & Interactions for SLC43A2 Gene

genes like me logo Genes that share pathways with SLC43A2: view

Interacting Proteins for SLC43A2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000301335 for SLC43A2 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC43A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0015807 L-amino acid transport IEA --
GO:0055085 transmembrane transport TAS --
GO:1902475 L-alpha-amino acid transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC43A2: view

No data available for SIGNOR curated interactions for SLC43A2 Gene

Drugs & Compounds for SLC43A2 Gene

(2) Additional Compounds for SLC43A2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC43A2: view

Transcripts for SLC43A2 Gene

mRNA/cDNA for SLC43A2 Gene

(9) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC43A2 Gene

Solute carrier family 43, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC43A2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14a ·
SP1: - - - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - -
SP8: - - - - -
SP11: - - - - -
SP12: -

ExUns: 14b · 14c ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20
SP7: -
SP9: - -
SP10: -

Relevant External Links for SLC43A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC43A2 Gene

mRNA expression in normal human tissues for SLC43A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC43A2 Gene

This gene is overexpressed in Whole Blood (x12.7) and Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for SLC43A2 Gene

This gene is overexpressed in Liver (42.4) and Placenta (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC43A2 Gene

SOURCE GeneReport for Unigene cluster for SLC43A2 Gene Hs.160550

mRNA Expression by UniProt/SwissProt for SLC43A2 Gene

Tissue specificity: Detected in several tissues with higher expression in placenta, kidney and peripheral blood leukocytes. In the kidney, is detected in epithelial cells of the distal tubule and collecting duct. In the intestine, is expressed mainly in crypt cells of the intestinal microvilli and epithelial cells in the base of the villus.
genes like me logo Genes that share expression patterns with SLC43A2: view

Primer Products

No data available for Protein tissue co-expression partners for SLC43A2 Gene

Orthologs for SLC43A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC43A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC43A2 35
  • 91.43 (n)
  • 94.72 (a)
SLC43A2 36
  • 95 (a)
(Canis familiaris)
Mammalia SLC43A2 35
  • 89.5 (n)
  • 94.54 (a)
SLC43A2 36
  • 95 (a)
(Mus musculus)
Mammalia Slc43a2 35
  • 87.79 (n)
  • 91.55 (a)
Slc43a2 16
Slc43a2 36
  • 92 (a)
(Pan troglodytes)
Mammalia SLC43A2 35
  • 97.73 (n)
  • 97.86 (a)
SLC43A2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc43a2 35
  • 88.38 (n)
  • 93.66 (a)
(Monodelphis domestica)
Mammalia SLC43A2 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia SLC43A2 36
  • 84 (a)
(Gallus gallus)
Aves SLC43A2 35
  • 77.22 (n)
  • 85.59 (a)
SLC43A2 36
  • 85 (a)
(Anolis carolinensis)
Reptilia SLC43A2 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc43a2 35
  • 72.54 (n)
  • 83.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5041 35
(Danio rerio)
Actinopterygii slc43a2b 35
  • 72.23 (n)
  • 76.91 (a)
slc43a2a 36
  • 77 (a)
slc43a2b 36
  • 73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11109 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for SLC43A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC43A2 Gene

Gene Tree for SLC43A2 (if available)
Gene Tree for SLC43A2 (if available)

Paralogs for SLC43A2 Gene

Paralogs for SLC43A2 Gene

(2) SIMAP similar genes for SLC43A2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC43A2: view

Variants for SLC43A2 Gene

Sequence variations from dbSNP and Humsavar for SLC43A2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs939564 -- 1,628,304(+) GGCAG(C/G)GGCAG intron-variant, utr-variant-5-prime
rs1051820 -- 1,574,767(-) CGAGG(G/T)GTGTG utr-variant-3-prime
rs1051844 -- 1,574,496(-) GCTTA(A/G)AGGGG utr-variant-3-prime
rs1057123 -- 1,575,203(-) CAGCC(A/G)TACCT downstream-variant-500B, utr-variant-3-prime
rs1107765 -- 1,592,646(-) TCTCC(C/T)ACCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC43A2 Gene

Variant ID Type Subtype PubMed ID
nsv833334 CNV Loss 17160897
nsv907502 CNV Loss 21882294
nsv907506 CNV Loss 21882294
nsv457635 CNV Gain 19166990
dgv3030n71 CNV Loss 21882294
nsv1945 CNV Insertion 18451855
esv1004030 CNV Deletion 20482838
esv2670177 CNV Deletion 23128226
esv2715472 CNV Deletion 23290073
nsv907509 CNV Loss 21882294
nsv907510 CNV Loss 21882294
nsv907511 CNV Loss 21882294
dgv3031n71 CNV Loss 21882294
nsv907513 CNV Loss 21882294
esv2660696 CNV Deletion 23128226
esv2715475 CNV Deletion 23290073
esv2715476 CNV Deletion 23290073
esv2715477 CNV Deletion 23290073
nsv527897 CNV Loss 19592680
nsv907515 CNV Loss 21882294
dgv3032n71 CNV Loss 21882294
nsv516055 CNV Gain+Loss 19592680
nsv907517 CNV Loss 21882294

Variation tolerance for SLC43A2 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC43A2 Gene

Disorders for SLC43A2 Gene

Relevant External Links for SLC43A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC43A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC43A2 Gene

Publications for SLC43A2 Gene

  1. The small SLC43 family: facilitator system l amino acid transporters and the orphan EEG1. (PMID: 23268354) Bodoy S. … PalacA-n M. (Mol. Aspects Med. 2013) 2 3 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast. (PMID: 21224231) Cleal J.K. … Lewis R.M. (J. Physiol. (Lond.) 2011) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3

Products for SLC43A2 Gene

Sources for SLC43A2 Gene