Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC43A1 Gene

protein-coding   GIFtS: 54
GCID: GC11M057252

Solute Carrier Family 43 (Amino Acid System L Transporter),...

(Previous name: prostate cancer overexpressed gene 1)
(Previous symbol: POV1)
  See SLC43A1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 43 (Amino Acid System L Transporter), Member
11 2
     Prostate Cancer Overexpressed Gene 11
POV11 2 3 5     R005042
LAT32 3 5     Large Neutral Amino Acids Transporter Small Subunit 32
Prostate Cancer Overexpressed Gene 1 Protein2 3     Solute Carrier Family 43, Member 12
PB392 3     Solute Carrier Family 43 Member 13
L-Type Amino Acid Transporter 32 3     

External Ids:    HGNC: 92251   Entrez Gene: 85012   Ensembl: ENSG000001491507   OMIM: 6037335   UniProtKB: O753873   

Export aliases for SLC43A1 gene to outside databases

Previous GC identifers: GC11M057502 GC11M057027 GC11M057008 GC11M053600


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC43A1 Gene:
SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino
acids (Babu et al., 2003 (PubMed 12930836)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC43A1 Gene:
SLC43A1 (solute carrier family 43 (amino acid system L transporter), member 1) is a protein-coding gene. Diseases associated with SLC43A1 include encephalomalacia, and prostate cancer. GO annotations related to this gene include neutral amino acid transmembrane transporter activity and L-amino acid transmembrane transporter activity. An important paralog of this gene is SLC43A3.

UniProtKB/Swiss-Prot: LAT3_HUMAN, O75387
Function: Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate
selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine.
Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive
prostate cancer

Gene Wiki entry for SLC43A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC43A1 gene promoter:
         MEF-2   RORalpha2   GATA-2   E47   MEF-2A   AREB6   N-Myc   aMEF-2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC43A1 promoter sequence
   Search Chromatin IP Primers for SLC43A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC43A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

SLC43A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC43A1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057252:  view genomic region     (about GC identifiers)

Start:
57,252,004 bp from pter      End:
57,283,259 bp from pter
Size:
31,256 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LAT3_HUMAN, O75387 (See protein sequence)
Recommended Name: Large neutral amino acids transporter small subunit 3  
Size: 559 amino acids; 61477 Da
Miscellaneous: Up-regulated in early prostate cancer development with highest expression level in seminomas of
testicular germ cell tumors
Alternative splicing: 2 isoforms:  O75387-1   O75387-2   

Explore the universe of human proteins at neXtProt for SLC43A1: NX_O75387

Explore proteomics data for SLC43A1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys264
  • Glycosylation2 at Asn57, Asn212, Asn229
  • Modification sites at PhosphoSitePlus

  • See SLC43A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001185739.1  NP_003618.1  

    ENSEMBL proteins: 
     ENSP00000278426   ENSP00000435673   ENSP00000433453   ENSP00000435803   ENSP00000434312  
     ENSP00000435647   ENSP00000432361   ENSP00000432241   ENSP00000435486  
    Reactome Protein details: O75387

    SLC43A1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC43A1
    GenScript Custom Purified and Recombinant Proteins Services for SLC43A1
    Novus Biologicals SLC43A1 Proteins
    Novus Biologicals SLC43A1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC43A1 

     
    antibodies-online proteins for SLC43A1 (4 products) 

     
    antibodies-online peptides for SLC43A1

    SLC43A1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SLC43A1
    OriGene Custom Antibody Services for SLC43A1
    Novus Biologicals SLC43A1 Antibodies
    Search for Antibodies for SLC43A1 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SLC43A1
    antibodies-online antibodies for SLC43A1 (8 products) 

    SLC43A1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC43A1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC43A1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SLC43A1 
    antibodies-online kits for SLC43A1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: L-type amino acid transporter 3
    SLC43 family of large neutral amino acid transporters

    2 InterPro protein domains:
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O75387

    ProtoNet protein and cluster: O75387

    UniProtKB/Swiss-Prot: LAT3_HUMAN, O75387
    Similarity: Belongs to the SLC43A transporter (TC 2.A.1.44) family


    Find genes that share domains with SLC43A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAT3_HUMAN, O75387
    Function: Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate
    selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine.
    Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive
    prostate cancer

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015175neutral amino acid transmembrane transporter activity IDA12930836
    GO:0015179L-amino acid transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC43A1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC43A1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC43A1:
    hsa-mir-27b-3p (MIRT046208), hsa-mir-484 (MIRT041721)

    Block miRNA regulation of human, mouse, rat SLC43A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC43A1 (see all 18):
    hsa-miR-623 hsa-miR-15a hsa-miR-3065-3p hsa-miR-29c hsa-miR-29a hsa-miR-497 hsa-miR-4290 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidSLC43A1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC43A1
    Predesigned siRNA for gene silencing in human, mouse, rat SLC43A1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC43A1

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC43A1 (see all 9)
    OriGene ORF clones in mouse, rat for SLC43A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC43A1 (NM_003627)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC43A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC43A1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC43A1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC43A1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC43A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LAT3_HUMAN, O75387: Membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS12930836
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SLC43A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC43A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Amino acid transport across the plasma membrane0.32


    Find genes that share SuperPaths with SLC43A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC43A1
        Amino acid transport across the plasma membrane


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC43A1
    Interactions:

        Search GeneGlobe Interaction Network for SLC43A1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC43A1 (O753873 ENSP000002784264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    ERGP113083, ENSP000003818914I2D: score=1 STRING: ENSP00000381891
    ATP6V1HENSP000003525224STRING: ENSP00000352522
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006865amino acid transport TAS--
    GO:0015804neutral amino acid transport IDA12930836
    GO:0015807L-amino acid transport ----
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLC43A1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC43A1 (LAT3)

    1 HMDB Compound for SLC43A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC43A1 gene (2 alternative transcripts): 
    NM_001198810.1  NM_003627.5  

    Unigene Cluster for SLC43A1:

    Solute carrier family 43, member 1
    Hs.591952  [show with all ESTs]
    Unigene Representative Sequence: NM_003627
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278426(uc001nkl.3) ENST00000528450(uc001nkk.3) ENST00000534298
    ENST00000525764 ENST00000529452 ENST00000533515 ENST00000530159 ENST00000533066
    ENST00000524995 ENST00000534105 ENST00000533263
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC43A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC43A1 (see all 18):
    hsa-miR-623 hsa-miR-15a hsa-miR-3065-3p hsa-miR-29c hsa-miR-29a hsa-miR-497 hsa-miR-4290 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidSLC43A1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC43A1
    Predesigned siRNA for gene silencing in human, mouse, rat SLC43A1
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC43A1 (see all 9)
    OriGene ORF clones in mouse, rat for SLC43A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC43A1 (NM_003627)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC43A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC43A1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC43A1
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC43A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC43A1
      QuantiTect SYBR Green Assays in human, mouse, rat SLC43A1
      QuantiFast Probe-based Assays in human, mouse, rat SLC43A1

    Additional mRNA sequence: 

    AB103033.1 AF045584.1 AK027732.1 BC001639.2 

    12 DOTS entries:

    DT.415269  DT.102827623  DT.75120558  DT.40123707  DT.95364920  DT.92429257  DT.40109130  DT.75153345 
    DT.92414849  DT.95088669  DT.95100065  DT.95346861 

    Selected AceView cDNA sequences (see all 114):

    AA040486 BF801187 BQ678583 BX956133 BM451394 BG397532 BC001639 AB103033 
    AI567334 AI859012 AA345572 BQ227946 NM_003627 BU182024 CR606379 BX494561 
    CO250090 BE396312 AK027732 BQ049835 BQ029981 AA447955 BG032562 BE617149 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC43A1 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:              -     -     -     -           -                                   -                 -     -     -                                             
    SP2:                                -           -                                   -                 -     -     -                                             
    SP3:                                            -                 -     -     -     -     -     -     -     -     -     -     -                                 
    SP4:                                                                                -     -     -     -     -     -     -     -     -     -     -               
    SP5:              -     -     -     -                                               -                                                                           

    ExUns: 21a · 21b · 21c ^ 22
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SLC43A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC43A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCTGTGTA
    SLC43A1 Expression
    About this image


    SLC43A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    SLC43A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC43A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591952

    UniProtKB/Swiss-Prot: LAT3_HUMAN, O75387
    Tissue specificity: In adults, found in all tissues examined with highest expression in pancreas. In fetus,
    highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells

        Custom PCR Arrays for SLC43A1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC43A1
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC43A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC43A1
    QuantiTect SYBR Green Assays in human, mouse, rat SLC43A1
    QuantiFast Probe-based Assays in human, mouse, rat SLC43A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC43A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC43A1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc43a11 , 5 solute carrier family 43, member 11, 5 84.2(n)1
    83.84(a)1
      2 (49.45 cM)5
    724011  NM_001083809.11  NP_001077278.11 
     848388505 
    lizard
    (Anolis carolinensis)
    Reptilia SLC43A16
    solute carrier family 43 (amino acid system L tran...
    69(a)
    1 ↔ 1
    1(91781430-91807859)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377176962   -- 71.04(n)    137717696 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi47a122 wufi47a12 76.32(n)   334395  BC044509.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Putative protein of unknown function; the authenti...
    22(a)
    1 → many
    XIII(713931-715445) YMR221C


    ENSEMBL Gene Tree for SLC43A1 (if available)
    TreeFam Gene Tree for SLC43A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC43A1 gene
    SLC43A32  SLC43A22  
    2 SIMAP similar genes for SLC43A1 using alignment to 7 protein entries:     LAT3_HUMAN (see all proteins):
    SLC43A2    SLC43A3

    Find genes that share paralogs with SLC43A1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC43A1 (see all 690)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1462453291,2
    --57251644(+) TTTTAA/CGATAA 2 -- int10--------
    rs1856625471,2
    --57251759(+) TCCTCC/TGTATG 2 -- int10--------
    rs125768321,2
    C,H--57251809(+) AAGTAG/AGGGGC 2 -- int11Minor allele frequency- A:0.00NA 2
    rs1117104931,2
    C--57251911(+) CAAGCG/TTCCTA 2 -- int10--------
    rs1909163311,2
    --57252153(+) AAAGGA/TGGGCT 2 -- ut310--------
    rs1827432511,2
    C--57252245(+) TTGCCA/GATCCC 2 -- ut310--------
    rs1858210021,2
    --57252248(+) CCGATC/TCCCCC 2 -- ut310--------
    rs776798171,2
    C,F--57252252(+) TCCCCC/GCAAGA 2 -- ut311Minor allele frequency- G:0.03EA 120
    rs28486341,2
    C,F,A,H--57252328(+) AAGAAA/GGCTCA 2 -- ut31 trp329Minor allele frequency- G:0.20NS EA NA WA CSA 2713
    rs1923314131,2
    --57252387(+) GGGGCA/GTTTTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC43A1 (57252004 - 57283259 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC43A1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC43A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC43A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603733    OMIM disorders: --

    2 diseases for SLC43A1:    
    About MalaCards
    encephalomalacia    prostate cancer


    Find genes that share disorders with SLC43A1           About GenesLikeMe

    3 Novoseek inferred disease relationships for SLC43A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    seminoma 64.2 2 16115909 (1), 14612934 (1)
    prostate cancer 26.4 6 9722952 (3), 14612934 (1)
    tumors 1.28 1 9722952 (1)


    Export disorders for SLC43A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC43A1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with SLC43A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA sequencing and analysis of POV1 (PB39): a novel gene up- regulated in prostate cancer. (PubMed id 9722952)1, 2, 3, 9 Cole K.A.... Emmert-Buck M.R. (Genomics 1998)
    2. Identification of a novel transcript up-regulated in a clinically aggressive prostate carcinoma. (PubMed id 9255310)1, 2, 3 Chuaqui R.F....Emmert-Buck M.R. (Urology 1997)
    3. Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. (PubMed id 12930836)1, 2, 9 Babu E.... Endou H. (J. Biol. Chem. 2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. New insights into testicular germ cell tumorigenesis from gene expression profiling. (PubMed id 11956097)1, 2 Skotheim R.I.... Kallioniemi A. (Cancer Res. 2002)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. Amino acid transport across mammalian intestinal and renal epithelia. (PubMed id 18195088)1 BrAPer S. (Physiol. Rev. 2008)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8501 HGNC: 9225 AceView: SLC43A1 Ensembl:ENSG00000149150 euGenes: HUgn8501
    ECgene: SLC43A1 H-InvDB: SLC43A1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC43A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC43A1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC43A1 gene:
    Search GeneIP for patents involving SLC43A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SLC43A1   OriGene RNAi products in human, mouse, rat for SLC43A1  
     OriGene qPCR primer pairs and template standards for SLC43A1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC43A1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC43A1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC43A1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC43A1   OriGene Custom Protein Services for SLC43A1  

     
     
     Block miRNA regulation of human, mouse, rat SLC43A1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC43A1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC43A1 Predesigned siRNA for gene silencing in human, mouse, rat SLC43A1
     QuantiFast Probe-based Assays in human, mouse, rat SLC43A1 QuantiTect SYBR Green Assays in human, mouse, rat SLC43A1
     Custom PCR Arrays for SLC43A1 Search Chromatin IP Primers for SLC43A1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC43A1  Search GeneGlobe Interaction Network for SLC43A1
     Regulatory tfbs in SLC43A1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC43A1 GenScript cDNA clones with any tag delivered in your preferred vector for SLC43A1
     GenScript Custom Assay Services for SLC43A1 GenScript Custom overexpressing Cell Line Services for SLC43A1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC43A1 (LAT3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC43A1 antibodies
     SLC43A1 proteins
     SLC43A1 lysates
     Search for Antibodies for SLC43A1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SLC43A1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC43A1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC43A1
     SwitchGear 3'UTR luciferase reporter plasmids for SLC43A1
     SwitchGear Promoter luciferase reporter plasmids for SLC43A1
     Search ThermoFisher Antibodies for SLC43A1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC43A1
     Browse compounds at ApexBio
     Search Addgene for plasmids for SLC43A1
      Search eBioscience for proteins for SLC43A1
      Search eBioscience for elisas for SLC43A1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SLC43A1
     antibodies-online antibodies for SLC43A1 (8 products)
     antibodies-online kits for SLC43A1 (4 products)
     antibodies-online peptides for SLC43A1
     antibodies-online proteins for SLC43A1 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC43A1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4