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Aliases for SLC43A1 Gene

Aliases for SLC43A1 Gene

  • Solute Carrier Family 43 (Amino Acid System L Transporter), Member 1 2 3
  • Prostate Cancer Overexpressed Gene 1 Protein 3 4
  • L-Type Amino Acid Transporter 3 3 4
  • LAT3 3 4
  • POV1 3 4
  • PB39 3 4
  • Prostate Cancer Overexpressed Gene 1 2
  • Solute Carrier Family 43, Member 1 3
  • Solute Carrier Family 43 Member 1 4
  • R00504 3

External Ids for SLC43A1 Gene

Previous HGNC Symbols for SLC43A1 Gene

  • POV1

Previous GeneCards Identifiers for SLC43A1 Gene

  • GC11M057027
  • GC11M057008
  • GC11M057252
  • GC11M053600

Summaries for SLC43A1 Gene

Entrez Gene Summary for SLC43A1 Gene

  • SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC43A1 Gene

SLC43A1 (Solute Carrier Family 43 (Amino Acid System L Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC43A1 include prostate cancer. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include neutral amino acid transmembrane transporter activity and L-amino acid transmembrane transporter activity. An important paralog of this gene is SLC43A3.

UniProtKB/Swiss-Prot for SLC43A1 Gene

  • Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.

Gene Wiki entry for SLC43A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC43A1 Gene

Genomics for SLC43A1 Gene

Regulatory Elements for SLC43A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC43A1 Gene

Chromosome:
11
Start:
57,484,531 bp from pter
End:
57,515,786 bp from pter
Size:
31,256 bases
Orientation:
Minus strand

Genomic View for SLC43A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC43A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC43A1 Gene

Proteins for SLC43A1 Gene

  • Protein details for SLC43A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75387-LAT3_HUMAN
    Recommended name:
    Large neutral amino acids transporter small subunit 3
    Protein Accession:
    O75387

    Protein attributes for SLC43A1 Gene

    Size:
    559 amino acids
    Molecular mass:
    61477 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Up-regulated in early prostate cancer development with highest expression level in seminomas of testicular germ cell tumors.

    Alternative splice isoforms for SLC43A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC43A1 Gene

Proteomics data for SLC43A1 Gene at MOPED

Post-translational modifications for SLC43A1 Gene

  • Ubiquitination at Lys 264
  • Glycosylation at Asn 57, Asn 212, and Asn 229
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC43A1

No data available for DME Specific Peptides for SLC43A1 Gene

Domains & Families for SLC43A1 Gene

Gene Families for SLC43A1 Gene

Protein Domains for SLC43A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC43A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75387

UniProtKB/Swiss-Prot:

LAT3_HUMAN :
  • Belongs to the SLC43A transporter (TC 2.A.1.44) family.
Family:
  • Belongs to the SLC43A transporter (TC 2.A.1.44) family.
genes like me logo Genes that share domains with SLC43A1: view

Function for SLC43A1 Gene

Molecular function for SLC43A1 Gene

UniProtKB/Swiss-Prot Function:
Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.

Gene Ontology (GO) - Molecular Function for SLC43A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015175 neutral amino acid transmembrane transporter activity IDA 12930836
GO:0015179 L-amino acid transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC43A1: view

Phenotypes for SLC43A1 Gene

GenomeRNAi human phenotypes for SLC43A1:
genes like me logo Genes that share phenotypes with SLC43A1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC43A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC43A1 Gene

Localization for SLC43A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC43A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC43A1 Gene COMPARTMENTS Subcellular localization image for SLC43A1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SLC43A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 12930836
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC43A1: view

Pathways & Interactions for SLC43A1 Gene

genes like me logo Genes that share pathways with SLC43A1: view

Interacting Proteins for SLC43A1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000278426%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000363822%0d%0a9606.ENSP00000381891%0d%0a
Selected Interacting proteins: O75387-LAT3_HUMAN ENSP00000278426 for SLC43A1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SLC43A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006865 amino acid transport TAS --
GO:0015804 neutral amino acid transport IDA 12930836
GO:0015807 L-amino acid transport --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC43A1: view

No data available for SIGNOR curated interactions for SLC43A1 Gene

Drugs & Compounds for SLC43A1 Gene

(1) Additional Compounds for SLC43A1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC43A1: view

Transcripts for SLC43A1 Gene

Unigene Clusters for SLC43A1 Gene

Solute carrier family 43, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC43A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC43A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - -
SP6: - - - - - - - -
SP7: - - -
SP8: - - - - - -
SP9: - - -
SP10: - - - -
SP11:
SP12:

ExUns: 21a · 21b · 21c ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SLC43A1 Gene

GeneLoc Exon Structure for
SLC43A1
ECgene alternative splicing isoforms for
SLC43A1

Expression for SLC43A1 Gene

mRNA expression in normal human tissues for SLC43A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC43A1 Gene

This gene is overexpressed in Pancreas (x13.1) and Liver (x8.3).

Protein differential expression in normal tissues from HIPED for SLC43A1 Gene

This gene is overexpressed in Pancreas (37.2), Fetal Liver (16.0), and Liver (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC43A1 Gene



SOURCE GeneReport for Unigene cluster for SLC43A1 Gene Hs.591952

mRNA Expression by UniProt/SwissProt for SLC43A1 Gene

O75387-LAT3_HUMAN
Tissue specificity: In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells.
genes like me logo Genes that share expression patterns with SLC43A1: view

Protein tissue co-expression partners for SLC43A1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC43A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC43A1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SLC43A1 35
  • 88.77 (n)
  • 87.46 (a)
SLC43A1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc43a1 35
  • 84.2 (n)
  • 83.84 (a)
Slc43a1 16
Slc43a1 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC43A1 35
  • 90.05 (n)
  • 87.55 (a)
rat
(Rattus norvegicus)
Mammalia Slc43a1 35
  • 84.05 (n)
  • 83.99 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC43A1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC43A1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC43A1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc43a1 35
  • 62.35 (n)
  • 66.08 (a)
zebrafish
(Danio rerio)
Actinopterygii slc43a1b 35
  • 65.7 (n)
  • 65.76 (a)
wufi47a12 35
slc43a1a 36
  • 60 (a)
OneToMany
slc43a1b 36
  • 61 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for SLC43A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC43A1 Gene

ENSEMBL:
Gene Tree for SLC43A1 (if available)
TreeFam:
Gene Tree for SLC43A1 (if available)

Paralogs for SLC43A1 Gene

Paralogs for SLC43A1 Gene

(2) SIMAP similar genes for SLC43A1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC43A1: view

Variants for SLC43A1 Gene

Sequence variations from dbSNP and Humsavar for SLC43A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs505057 -- 57,508,227(+) gcacc(A/C)ctgca intron-variant
rs533719 -- 57,508,264(+) tccat(C/T)tccaa intron-variant
rs548788 -- 57,512,362(-) CACCC(A/G)GCTCG intron-variant
rs1001956 -- 57,499,476(+) CGCCA(C/G)GGAAG intron-variant, upstream-variant-2KB
rs1970812 -- 57,499,328(+) aacaa(A/C)aaaaa intron-variant, upstream-variant-2KB

Variation tolerance for SLC43A1 Gene

Residual Variation Intolerance Score: 24.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC43A1 Gene

HapMap Linkage Disequilibrium report
SLC43A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC43A1 Gene

Disorders for SLC43A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC43A1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association

Relevant External Links for SLC43A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC43A1
genes like me logo Genes that share disorders with SLC43A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC43A1 Gene

Publications for SLC43A1 Gene

  1. cDNA sequencing and analysis of POV1 (PB39): a novel gene up- regulated in prostate cancer. (PMID: 9722952) Cole K.A. … Emmert-Buck M.R. (Genomics 1998) 2 23 67
  2. Identification of two molecular groups of seminomas by using expression and tissue microarrays. (PMID: 16115909) Hofer M.D. … Rubin M.A. (Clin. Cancer Res. 2005) 23 67
  3. Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray. (PMID: 14612934) Okada K. … Nakamura Y. (Int. J. Oncol. 2003) 23 67
  4. Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. (PMID: 12930836) Babu E. … Endou H. (J. Biol. Chem. 2003) 23 67
  5. EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis. (PMID: 11704567) Stuart R.O. … Nigam S.K. (Am. J. Physiol. Renal Physiol. 2001) 23 67

Products for SLC43A1 Gene

Sources for SLC43A1 Gene

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