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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC41A3 Gene

protein-coding GIFtS: 48
GCID: GC03M125725

solute carrier family 41, member 3

Search for SLC41A3
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 41, Member 3¹ ²
FLJ20473¹
SLC41A1-L2²
SLC41A1-Like 2²
Solute Carrier Family 41 Member 3²

External Ids:	HGNC: 31046¹	Entrez Gene: 54946²	Ensembl: ENSG00000114544⁷	OMIM: 610803⁵	UniProtKB: Q96GZ6³

Export aliases for SLC41A3 gene to outside databases

Previous GC identifers: GC03M127046 GC03M127207 GC03M123105

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for SLC41A3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SLC41A3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC41A3 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC41A3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC41A3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.2 Ensembl cytogenetic band: 3q21.3 HGNC cytogenetic band: 3q21.2

SLC41A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC41A3 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M125725: view genomic region (about GC identifiers)

Start:	125,725,198 bp from pter	End:	125,820,404 bp from pter
Size:	95,207 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S41A3_HUMAN, Q96GZ6 (See protein sequence)

Recommended Name: Solute carrier family 41 member 3

Size: 507 amino acids; 54767 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: A6ND60 B3KSD9 B7Z4Y2 C9JE96 Q8N342 Q8NB27 Q9H9I6 Q9HAB1 Q9NX30

Alternative splicing: 8 isoforms: Q96GZ6-1 Q96GZ6-2 Q96GZ6-3 Q96GZ6-4 Q96GZ6-5 Q96GZ6-6 Q96GZ6-7 Q96GZ6-8

(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC41A3: NX_Q96GZ6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96GZ6

SLC41A3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001008485.1 NP_001008486.1 NP_001008487.1 NP_001157947.1 NP_060306.3

ENSEMBL proteins:

ENSP00000353533 ENSP00000264471 ENSP00000373092 ENSP00000326070 ENSP00000427409

ENSP00000425311 ENSP00000422828 ENSP00000425373 ENSP00000421008 ENSP00000423524

ENSP00000422458 ENSP00000422531 ENSP00000423154 ENSP00000421940 ENSP00000424882

ENSP00000427254 ENSP00000422150

Human Recombinant Protein Products for SLC41A3:

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	Uscn Proteins for SLC41A3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

SLC41A3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SLC41A3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC41A3 for domains About GeneDecksing

1 InterPro domain/family:

IPR006667 MgtE_Mg_transptr_membr

Graphical View of Domain Structure for InterPro Entry Q96GZ6

ProtoNet protein and cluster: Q96GZ6

UniProtKB/Swiss-Prot: S41A3_HUMAN, Q96GZ6

Similarity: Belongs to the SLC41A transporter family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008324	cation transmembrane transporter activity	IEA	--

SLC41A3 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for SLC41A3:

Decreased influenza A virus in

Elongated cells with protrusio

Increased gamma-H2AX phosphory

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Slc41a3):

behavior/neurological

SLC41A3 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC41A3

miRNA Products:		OriGene 3'-UTR Clone (see all 5): SLC41A3 Browse MicroRNA Expression Plasmids
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC41A3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC41A3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

5/6 Interacting proteins for SLC41A3 (Q96GZ6^{2, 3} ENSP00000326070⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK6	Q16659²^,³	MINT-8261967 I2D: score=2
PDCD6	O75340³	I2D: score=3
SREBF2	Q12772³	I2D: score=2
CREB3	O43889³	I2D: score=1
SUFU	Q9UMX1³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC41A3
Search CenterWatch for drugs/clinical trials and news about SLC41A3 / S41A3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC41A3 gene (5 alternative transcripts):

NM_001008485.1 NM_001008486.1 NM_001008487.1 NM_001164475.1 NM_017836.3

Unigene Cluster for SLC41A3:

Solute carrier family 41, member 3

Hs.573007 [show with all ESTs]

Unigene Representative Sequence: AK128054

18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000360370(uc003eil.3 uc011bkh.2) ENST00000346785(uc003eik.3)

ENST00000504118 ENST00000383598(uc003eii.3) ENST00000506102 ENST00000512557

ENST00000315891(uc003eij.3 uc010hsd.1) ENST00000508835 ENST00000507008

ENST00000514677 ENST00000513723 ENST00000514023 ENST00000513464 ENST00000512470

ENST00000510651 ENST00000514333 ENST00000507280 ENST00000514891

miRNA Products:		OriGene 3'-UTR Clone (see all 5): SLC41A3 Browse OriGene MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against SLC41A3

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Additional cDNA sequence:

AK000480.1 AK021925.1 AK022780.1 AK091671.1 AK093380.1 AK094051.1 AK128054.1 AK298070.1

AK307107.1 BC009039.2 BC009444.1 BC028241.1 BC035753.1

24/27 DOTS entries (see all 27):

DT.92438758 DT.95168589 DT.100812432 DT.100812428 DT.100812436 DT.453805 DT.100812438 DT.95095091

DT.100812433 DT.100731442 DT.100812421 DT.100812427 DT.100028405 DT.92028193 DT.120923769 DT.100812439

DT.120923736 DT.100812420 DT.100812422 DT.100812441 DT.120923720 DT.120923739 DT.95168592 DT.100812419

24/289 AceView cDNA sequences (see all 289):

CR617540 AW589954 AK000480 BE504265 AA243847 BM794344 W44759 BU623092

CA417634 AA936951 BQ924837 AI273243 AW294446 CR603915 AW665544 AI969750

CR594553 AI150958 H39508 AI298574 AA046886 BE504248 CR625923 AA421100

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for SLC41A3 (see all 20) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	·	8e	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	^	12	^	13	^	14a	·	14b	·
SP1:							-		-		-						-		-		-										-		-														-
SP2:							-		-		-						-		-		-										-		-														-
SP3:																	-		-		-										-		-														-
SP4:																	-		-		-		-		-		-		-		-		-														-
SP5:																															-		-														-

ExUns:	14c	·	14d	·	14e	^	15a	·	15b	·	15c	^	16	^	17	^	18	^	19	^	20
SP1:
SP2:	-		-		-		-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SLC41A3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC41A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAACCCAGAT

About this image

SLC41A3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC41A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC41A3

SOURCE GeneReport for Unigene cluster: Hs.573007

SABiosciences Custom PCR Arrays for SLC41A3

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLC41A3 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC41A3⁶	Uncharacterized protein	57(a)	1 ↔ 1	12(10786005-10802689)
lizard (Anolis carolinensis)	Reptilia	SLC41A3⁶	--	55(a)	1 ↔ 1	2(168802202-168831722)
zebrafish (Danio rerio)	Actinopterygii	BX294434.1⁶	--	54(a)	1 ↔ 1	23(35029168-35066622)
fruit fly (Drosophila melanogaster)	Insecta	CG33181⁶	--	24(a)	1 → many	X(8383381-8411062)
worm (Caenorhabditis elegans)	Secernentea	K07H8.2⁶ ZK185.2⁶ (see all 3)	Protein ZK185.2 (see all 3)	38(a) 31(a) (see all 3)	many ↔ many many ↔ many (see all 3)	IV(8291526-8294583) IV(4536546-4541764)

ENSEMBL Gene Tree for SLC41A3 (if available)
TreeFam Gene Tree for SLC41A3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC41A3 gene

SLC41A2² SLC41A1²

2 SIMAP similar genes for SLC41A3 using alignment to 13 protein entries: S41A3_HUMAN (see all proteins):

SLC41A1 SLC41A2

SLC41A3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112075715^1,2	C	--	125724746(+)	`CATGTC/ATTTCC`	5	--	ds500¹		2		CSA WA	120
rs113287225^1,2		--	125724941(+)	`TCAAAA/C/TGTGGG`	5	--	ds500¹		1		CSA	2
rs182999457^1,2		--	125724942(+)	`CAAACA/GTGGGT`	5	--	ds500¹		0	--	--	--	--
rs6438953^1,2	C,F,A,H	--	125724951(+)	`GTGTGT/CATGAG`	5	--	ds500¹		21		NS EA NA WA CSA	2351
rs111816471^1,2		--	125725074(+)	`CTGGTG/AACACT`	5	--	ds500¹		1		CSA	2
rs9813508^1,2	C,F,H	--	125725130(+)	`AAATGC/GCAGAT`	5	--	ds500¹		5		NS EA WA	502
rs112859106^1,2	C	--	125725242(+)	`TGATTA/GTTGAA`	5	--	ut3¹		2		CSA WA	120
rs138918975^1,2	C	--	125725269(+)	`TTGCT-/AACA AACAA`	7	* LL	fra¹ ut3¹		0	--	--	--	--
rs200886927^1,2	C	--	125725272(+)	`CTAACA/C/TAACAA`	12	* W L	ut3¹ stg¹ mis¹		1		EU	1237
rs9833685^1,2	C,F,H	--	125725334(+)	`AAGGGT/CTGTAT`	7	/Q	ut3¹ syn¹ ese³		14		NS EA NA WA EU	7303

HapMap Linkage Disequilibrium report for SLC41A3 (125725198 - 125820404 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLC41A3
1 CNV: 4352
1 Inversion: 59786

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC41A3

DNA2.0 Custom Variant and Variant Library Synthesis for SLC41A3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC41A3 for disorders About MalaCards

SLC41A3 for disorders About GeneDecksing

OMIM gene information: 610803 OMIM disorders: --

Export disorders for SLC41A3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC41A3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC41A3)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)¹ Beausoleil S.A....Gygi S.P. (2004)
The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. (PubMed id 12810078)¹ Wabakken T.... Aasheim H.-C. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)¹ Dias Neto E....Simpson A.J.G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 54946	HGNC: 31046	AceView: SLC41A3	Ensembl:ENSG00000114544	euGenes: HUgn54946
ECgene: SLC41A3	H-InvDB: SLC41A3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLC41A3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC41A3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC41A3 gene:
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SLC41A3 Gene

solute carrier family 41, member 3

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SLC41A3 Gene

solute carrier family 41, member 3

Aliasesfor SLC41A3 gene

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