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Aliases for SLC41A2 Gene

Aliases for SLC41A2 Gene

  • Solute Carrier Family 41 (Magnesium Transporter), Member 2 2 3
  • Solute Carrier Family 41, Member 2 2 3
  • Solute Carrier Family 41 Member 2 3
  • SLC41A1-Like 1 3
  • SLC41A1-L1 3

External Ids for SLC41A2 Gene

Summaries for SLC41A2 Gene

GeneCards Summary for SLC41A2 Gene

SLC41A2 (Solute Carrier Family 41 (Magnesium Transporter), Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC41A1.

UniProtKB/Swiss-Prot for SLC41A2 Gene

  • Acts as a plasma-membrane magnesium transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC41A2 Gene

Genomics for SLC41A2 Gene

Genomic Location for SLC41A2 Gene

Start:
104,802,553 bp from pter
End:
104,958,744 bp from pter
Size:
156,192 bases
Orientation:
Minus strand

Genomic View for SLC41A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC41A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC41A2 Gene

Regulatory Elements for SLC41A2 Gene

Proteins for SLC41A2 Gene

  • Protein details for SLC41A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JW4-S41A2_HUMAN
    Recommended name:
    Solute carrier family 41 member 2
    Protein Accession:
    Q96JW4
    Secondary Accessions:
    • Q3KP68
    • Q9H0E5

    Protein attributes for SLC41A2 Gene

    Size:
    573 amino acids
    Molecular mass:
    62473 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36734.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI06872.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI06873.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55402.1; Type=Frameshift; Positions=69, 101, 103; Evidence={ECO:0000305}; Sequence=CAB66762.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC41A2 Gene

Proteomics data for SLC41A2 Gene at MOPED

Post-translational modifications for SLC41A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC41A2 Gene

No data available for DME Specific Peptides for SLC41A2 Gene

Domains for SLC41A2 Gene

Gene Families for SLC41A2 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC41A2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

S41A2_HUMAN
Family:
  • Belongs to the SLC41A transporter family.:
    • Q96JW4
genes like me logo Genes that share domains with SLC41A2: view

Function for SLC41A2 Gene

Molecular function for SLC41A2 Gene

UniProtKB/Swiss-Prot Function: Acts as a plasma-membrane magnesium transporter.

Gene Ontology (GO) - Molecular Function for SLC41A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008324 cation transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC41A2: view

Phenotypes for SLC41A2 Gene

GenomeRNAi human phenotypes for SLC41A2:
genes like me logo Genes that share phenotypes with SLC41A2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC41A2 Gene

Localization for SLC41A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC41A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC41A2 Gene COMPARTMENTS Subcellular localization image for SLC41A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC41A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC41A2: view

Pathways for SLC41A2 Gene

genes like me logo Genes that share pathways with SLC41A2: view

Interacting Proteins for SLC41A2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000258538%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000404220%0d%0a
Selected Interacting proteins: ENSP00000258538 Q96JW4-S41A2_HUMAN for SLC41A2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SLC41A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0055085 transmembrane transport TAS --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC41A2: view

Compounds for SLC41A2 Gene

(1) HMDB Compounds for SLC41A2 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with SLC41A2: view

Transcripts for SLC41A2 Gene

Unigene Clusters for SLC41A2 Gene

Solute carrier family 41, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC41A2 Gene

No ASD Table

Relevant External Links for SLC41A2 Gene

GeneLoc Exon Structure for
SLC41A2
ECgene alternative splicing isoforms for
SLC41A2

Expression for SLC41A2 Gene

mRNA expression in normal human tissues for SLC41A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC41A2 Gene

This gene is overexpressed in Liver (7.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC41A2 Gene

SOURCE GeneReport for Unigene cluster for SLC41A2 Gene Hs.577463

genes like me logo Genes that share expressions with SLC41A2: view

Orthologs for SLC41A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC41A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC41A2 36
  • 99.71 (n)
  • 99.83 (a)
SLC41A2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC41A2 36
  • 91.97 (n)
  • 94.94 (a)
SLC41A2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC41A2 36
  • 91.51 (n)
  • 93.89 (a)
SLC41A2 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc41a2 36
  • 84.03 (n)
  • 91.26 (a)
Slc41a2 16
Slc41a2 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC41A2 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC41A2 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc41a2 36
  • 83.03 (n)
  • 90.88 (a)
chicken
(Gallus gallus)
Aves SLC41A2 36
  • 79.87 (n)
  • 84.82 (a)
SLC41A2 37
  • 85 (a)
OneToMany
SLC41A2 37
  • 81 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SLC41A2 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc41a2 36
  • 74.12 (n)
  • 81.33 (a)
Str.4263 36
zebrafish
(Danio rerio)
Actinopterygii LOC566242 36
  • 66.27 (n)
  • 74.07 (a)
SLC41A2 (2 of 2) 37
  • 59 (a)
OneToMany
slc41a2b 37
  • 68 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000663 36
  • 48.28 (n)
  • 40.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33181 36
  • 48.48 (n)
  • 44.06 (a)
CG33181 37
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K07H8.2 37
  • 42 (a)
ManyToMany
ZK1053.6 37
  • 24 (a)
ManyToMany
ZK185.2 37
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 54 (a)
OneToMany
Species with no ortholog for SLC41A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC41A2 Gene

ENSEMBL:
Gene Tree for SLC41A2 (if available)
TreeFam:
Gene Tree for SLC41A2 (if available)

Paralogs for SLC41A2 Gene

Paralogs for SLC41A2 Gene

Selected SIMAP similar genes for SLC41A2 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for SLC41A2 Gene

genes like me logo Genes that share paralogs with SLC41A2: view

Variants for SLC41A2 Gene

Sequence variations from dbSNP and Humsavar for SLC41A2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs969629 -- 104,831,380(-) TTTAC(A/G)TTTGG intron-variant
rs996294 -- 104,868,762(+) CTATT(A/C)CTTGG intron-variant
rs1027339 -- 104,859,997(+) cttgg(C/T)ctcgc intron-variant
rs1155994 -- 104,837,415(-) GGACA(A/G)TGAGA intron-variant
rs1389612 -- 104,829,800(-) atgtt(A/G)aaaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC41A2 Gene

Variant ID Type Subtype PubMed ID
nsv899495 CNV Gain 21882294
nsv899496 CNV Gain 21882294
nsv899497 CNV Loss 21882294
nsv899498 CNV Gain 21882294
nsv832505 CNV Gain 17160897
esv269511 CNV Insertion 20981092

Relevant External Links for SLC41A2 Gene

HapMap Linkage Disequilibrium report
SLC41A2

Disorders for SLC41A2 Gene

Relevant External Links for SLC41A2

Genetic Association Database (GAD)
SLC41A2
genes like me logo Genes that share disorders with SLC41A2: view

No data available for UniProtKB/Swiss-Prot for SLC41A2 Gene

Publications for SLC41A2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. SLC41A2 encodes a plasma-membrane Mg2+ transporter. (PMID: 16984228) Sahni J. … Scharenberg A.M. (Biochem. J. 2007) 4 23
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. (PMID: 12810078) Wabakken T. … Aasheim H.-C. (Biochem. Biophys. Res. Commun. 2003) 3

Products for SLC41A2 Gene

  • antibodies-online peptides for SLC41A2
  • antibodies-online antibodies for SLC41A2
  • antibodies-online kits for SLC41A2

Sources for SLC41A2 Gene

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