SLC41A2 Gene
protein-coding GIFtS: 46
GCID: GC12M105197
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|
solute carrier family 41, member 2
| |
Aliases
for SLC41A2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 41, Member 21 2 | | DKFZP434K04271 | | SLC41A1-L12 | | SLC41A1-Like 12 | | Solute Carrier Family 41 Member 22 |
Export aliases for SLC41A2 gene to outside databasesPrevious GC identifers: GC12M103701 GC12M103702 GC12M102256 |
Summaries
for SLC41A2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: S41A2_HUMAN, Q96JW4Function: Acts as a plasma-membrane magnesium transporter
|
Genomic Views
for SLC41A2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC41A2 gene promoter:
AREB6 TBP S8 Nkx2-5 POU6F1 (c2) E4BP4 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC41A2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC41A2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q23.3 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q24.11SLC41A2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M105197: view genomic region
(about GC identifiers)
Start:
|
105,196,331 bp from pter |
End:
|
105,352,522 bp from pter |
Size:
|
156,192 bases |
Orientation:
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minus strand |
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Proteins
for SLC41A2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S41A2_HUMAN, Q96JW4 (See
protein sequence)Recommended Name: Solute carrier family 41 member 2 Size: 573 amino acids; 62473 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAH36734.1; Type=Erroneous initiation; Sequence=AAI06872.2; Type=Erroneous initiation;Sequence=AAI06873.2; Type=Erroneous initiation; Sequence=BAB55402.1; Type=Frameshift; Positions=69, 101, 103;Sequence=CAB66762.1; Type=Erroneous initiation;
Secondary accessions: Q3KP68 Q9H0E5Explore the universe of human proteins at neXtProt for SLC41A2: NX_Q96JW4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96JW4
SLC41A2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115524.3
ENSEMBL proteins: ENSP00000258538 ENSP00000391377 ENSP00000396429 ENSP00000407898 ENSP00000414526 ENSP00000395550 ENSP00000397315 ENSP00000396297 ENSP00000410625 Reactome Protein details: Q96JW4
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SLC41A2 for ontologies About GeneDecksing
SLC41A2 Antibody Products:
Assay Products for SLC41A2: |
Protein
Domains /
Families
for SLC41A2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC41A2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96JW4ProtoNet protein and cluster: Q96JW4 UniProtKB/Swiss-Prot: S41A2_HUMAN, Q96JW4Similarity: Belongs to the SLC41A transporter family |
Function
for SLC41A2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S41A2_HUMAN, Q96JW4Function: Acts as a plasma-membrane magnesium transporter
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC41A2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC41A2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC41A2 (NM_032148) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC41A2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC41A2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC41A2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008324 | cation transmembrane transporter activity |
IEA | -- |
SLC41A2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SLC41A2:
|
Pathways & Interactions
for SLC41A2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | SLC-mediated transmembrane transport | | | 2 | Zinc transporters | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for SLC41A2
SLC41A2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC41A2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0055085 | transmembrane transport |
TAS | -- |
SLC41A2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC41A2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC41A2
1 HMDB Compound for SLC41A2 About this table
Search CenterWatch for drugs/clinical trials and news about SLC41A2 / S41A2
|
Transcripts
for SLC41A2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC41A2 gene: NM_032148.3 Unigene Cluster for SLC41A2: Solute carrier family 41, member 2 Hs.577463 [show with all ESTs]Unigene Representative Sequence: NM_03214810 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000258538(uc001tla.3) ENST00000549713 ENST00000437220 ENST00000415674
ENST00000411411 ENST00000449866 ENST00000433540 ENST00000424946 ENST00000417469
ENST00000432951
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC41A2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC41A2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC41A2 (NM_032148) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC41A2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC41A2 |
Additional cDNA sequence: AK027838.1 AL136828.1 BC036734.1 BC106871.1 BC106872.1 6 DOTS entries: DT.40123011 DT.307211 DT.100736414 DT.121190669 DT.121190664 DT.97779819 24/50 AceView cDNA sequences (see all 50): AL136828 AA938600 AA455987 AW016390 AK027838 CA438691 BF589238 BG562989 BU753775 AI471124 BX114417 CB962857 CA942227 BG623531 BF432428 BI913563 AW026357 CD516297 CA941943 BC036734 BM855894 BU753121 NM_032148 AI683853
GeneLoc Exon Structure
|
Expression
for SLC41A2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC41A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTAAGTTG
About this image
See SLC41A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC41A2
SOURCE GeneReport for Unigene cluster: Hs.577463
SABiosciences Custom PCR Arrays for SLC41A2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC41A2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC41A2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC41A2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC41A2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC41A2 |
Orthologs
for SLC41A2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SLC41A2 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for SLC41A2 (if available)
TreeFam Gene Tree for SLC41A2 (if available) |
Paralogs
for SLC41A2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC41A2 gene
- SLC41A32 SLC41A12
2 SIMAP similar genes for SLC41A2 using alignment to 9 protein entries: S41A2_HUMAN (see all proteins):SLC41A1 SLC41A3
SLC41A2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SLC41A2
PGOHUM00000259271
|
Genomic Variants
for SLC41A2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC41A2 (105196331 - 105352522 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC41A2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC41A2 |
|
Disorders
/ Diseases
for SLC41A2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SLC41A2 for disorders About MalaCards
SLC41A2 for disorders About GeneDecksing
OMIM gene information: 610802
OMIM disorders: --
Export disorders for SLC41A2 gene to outside databases
|
Publications
for SLC41A2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC41A2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC41A2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- SLC41A2 encodes a plasma-membrane Mg2+ transporter. (PubMed id 16984228)2, 9 Sahni J.... Scharenberg A.M. (2007)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Functional characterization of the mouse [corrected] solute carrier, SLC41A2. (PubMed id 15809054)1 Goytain A. and Quamme G.A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. (PubMed id 12810078)1 Wabakken T.... Aasheim H.-C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC41A2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC41A2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC41A2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC41A2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC41A2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC41A2 gene:
Search GeneIP for patents involving SLC41A2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC41A2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC41A2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC41A2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC41A2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC41A2 | | OriGene 3'-UTR Clone for SLC41A2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC41A2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC41A2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLC41A2 | | OriGene Custom Protein Services for SLC41A2 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC41A2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC41A2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC41A2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC41A2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC41A2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC41A2 |
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 |  |  |  | |
| | | | Search Tocris compounds for SLC41A2 |
| |  |  |  |  | | | | |
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 | | | SLC41A2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC41A2 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC41A2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC41A2 |
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