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Aliases for SLC41A1 Gene

Aliases for SLC41A1 Gene

  • Solute Carrier Family 41 (Magnesium Transporter), Member 1 2 3
  • Solute Carrier Family 41, Member 1 3
  • Solute Carrier Family 41 Member 1 3
  • MgtE 3

External Ids for SLC41A1 Gene

Previous GeneCards Identifiers for SLC41A1 Gene

  • GC01M201219
  • GC01M202119
  • GC01M202935
  • GC01M202489
  • GC01M204025
  • GC01M205758
  • GC01M176922

Summaries for SLC41A1 Gene

GeneCards Summary for SLC41A1 Gene

SLC41A1 (Solute Carrier Family 41 (Magnesium Transporter), Member 1) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC41A2.

UniProtKB/Swiss-Prot for SLC41A1 Gene

  • Acts as a magnesium transporter that is responsive to magnesium balance.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC41A1 Gene

Genomics for SLC41A1 Gene

Regulatory Elements for SLC41A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC41A1 Gene

205,789,093 bp from pter
205,813,759 bp from pter
24,667 bases
Minus strand

Genomic View for SLC41A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC41A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC41A1 Gene

Proteins for SLC41A1 Gene

  • Protein details for SLC41A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 41 member 1
    Protein Accession:
    Secondary Accessions:
    • Q63HJ4
    • Q658Z5
    • Q659A4
    • Q6MZK2

    Protein attributes for SLC41A1 Gene

    513 amino acids
    Molecular mass:
    54901 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC41A1 Gene

Proteomics data for SLC41A1 Gene at MOPED

Post-translational modifications for SLC41A1 Gene

  • Ubiquitination at Lys170
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC41A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC41A1 Gene

Domains for SLC41A1 Gene

Gene Families for SLC41A1 Gene

  • SLC :Solute carriers

Protein Domains for SLC41A1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q8IVJ1
  • Belongs to the SLC41A transporter family.
genes like me logo Genes that share domains with SLC41A1: view

Function for SLC41A1 Gene

Molecular function for SLC41A1 Gene

UniProtKB/Swiss-Prot Function: Acts as a magnesium transporter that is responsive to magnesium balance.

Gene Ontology (GO) - Molecular Function for SLC41A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008324 cation transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC41A1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC41A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC41A1 Gene

Localization for SLC41A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC41A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC41A1 Gene COMPARTMENTS Subcellular localization image for SLC41A1 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC41A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC41A1: view

Pathways for SLC41A1 Gene

genes like me logo Genes that share pathways with SLC41A1: view

Interacting Proteins for SLC41A1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000356105 for SLC41A1 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC41A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0055085 transmembrane transport TAS --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC41A1: view

Compounds for SLC41A1 Gene

(1) HMDB Compounds for SLC41A1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Magnesium
genes like me logo Genes that share compounds with SLC41A1: view

Transcripts for SLC41A1 Gene

Unigene Clusters for SLC41A1 Gene

Solute carrier family 41, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC41A1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC41A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC41A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2: - - - -
SP3: -

Relevant External Links for SLC41A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC41A1 Gene

mRNA expression in normal human tissues for SLC41A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC41A1 Gene

This gene is overexpressed in Heart - Left Ventricle (8.9) and Heart - Atrial Appendage (4.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC41A1 Gene

SOURCE GeneReport for Unigene cluster for SLC41A1 Gene Hs.20274

mRNA Expression by UniProt/SwissProt for SLC41A1 Gene

Tissue specificity: Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen.
genes like me logo Genes that share expressions with SLC41A1: view

In Situ Assay Products

Orthologs for SLC41A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC41A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC41A1 35
  • 99.74 (n)
  • 100 (a)
SLC41A1 36
  • 100 (a)
(Bos Taurus)
Mammalia SLC41A1 35
  • 90.38 (n)
  • 96.69 (a)
SLC41A1 36
  • 96 (a)
(Canis familiaris)
Mammalia SLC41A1 35
  • 93.5 (n)
  • 98.25 (a)
SLC41A1 36
  • 98 (a)
(Mus musculus)
Mammalia Slc41a1 35
  • 91.73 (n)
  • 97.85 (a)
Slc41a1 16
Slc41a1 36
  • 98 (a)
(Monodelphis domestica)
Mammalia SLC41A1 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
-- 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Slc41a1 35
  • 92.2 (n)
  • 98.05 (a)
(Gallus gallus)
Aves SLC41A1 35
  • 78.88 (n)
  • 86.94 (a)
SLC41A1 36
  • 87 (a)
(Anolis carolinensis)
Reptilia SLC41A1 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc41a1 35
  • 70.7 (n)
  • 78.17 (a)
Str.15281 35
(Danio rerio)
Actinopterygii slc41a1 35
  • 74.13 (n)
  • 80.96 (a)
slc41a1 36
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33181 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea K07H8.2 35
  • 52.61 (n)
  • 49.88 (a)
K07H8.2 36
  • 43 (a)
ZK1053.6 36
  • 25 (a)
ZK185.2 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
Species with no ortholog for SLC41A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC41A1 Gene

Gene Tree for SLC41A1 (if available)
Gene Tree for SLC41A1 (if available)

Paralogs for SLC41A1 Gene

Paralogs for SLC41A1 Gene

Selected SIMAP similar genes for SLC41A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC41A1: view

Variants for SLC41A1 Gene

Sequence variations from dbSNP and Humsavar for SLC41A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2224 -- 205,800,423(+) GGCCC(A/G)GAATC intron-variant
rs708726 -- 205,793,011(-) TGAAG(A/C)GTCAT intron-variant
rs708727 -- 205,798,757(+) GCCAC(A/G)TTGTC reference, synonymous-codon
rs708729 -- 205,804,333(+) GCATA(C/T)GCTTG intron-variant
rs708730 -- 205,808,652(+) GTCCC(A/G)GCCCT intron-variant

Relevant External Links for SLC41A1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC41A1 Gene

Disorders for SLC41A1 Gene

Relevant External Links for SLC41A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC41A1: view

No data available for UniProtKB/Swiss-Prot for SLC41A1 Gene

Publications for SLC41A1 Gene

  1. The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. (PMID: 12810078) Wabakken T. … Aasheim H.-C. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23
  2. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. (PMID: 21738487) Do C.B. … Eriksson N. (PLoS Genet. 2011) 3 48
  3. Genetic variability at the PARK16 locus. (PMID: 20683486) Tucci A. … PaisA!n-Ruiz C. (Eur. J. Hum. Genet. 2010) 3 48
  4. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. (PMID: 19915576) Satake W. … Toda T. (Nat. Genet. 2009) 3 48
  5. SLC41A1 is a novel mammalian Mg2+ carrier. (PMID: 18367447) Kolisek M. … Schweigel M. (J. Biol. Chem. 2008) 2 3

Products for SLC41A1 Gene

  • antibodies-online peptides for SLC41A1
  • antibodies-online antibodies for SLC41A1
  • antibodies-online kits for SLC41A1

Sources for SLC41A1 Gene

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