Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC41A1 Gene

Aliases for SLC41A1 Gene

  • Solute Carrier Family 41 Member 1 2 3 5
  • Solute Carrier Family 41 (Magnesium Transporter), Member 1 2 3
  • MgtE 3

External Ids for SLC41A1 Gene

Previous GeneCards Identifiers for SLC41A1 Gene

  • GC01M201219
  • GC01M202119
  • GC01M202935
  • GC01M202489
  • GC01M204025
  • GC01M205758
  • GC01M176922

Summaries for SLC41A1 Gene

GeneCards Summary for SLC41A1 Gene

SLC41A1 (Solute Carrier Family 41 Member 1) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC41A2.

UniProtKB/Swiss-Prot for SLC41A1 Gene

  • Acts as a magnesium transporter that is responsive to magnesium balance.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC41A1 Gene

Genomics for SLC41A1 Gene

Regulatory Elements for SLC41A1 Gene

Enhancers for SLC41A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G205786 1.1 ENCODE dbSUPER 12 +26.6 26595 1.6 HDAC1 HDGF ATF1 RB1 EGR1 GATA2 CREM ZEB2 HDAC8 ZNF592 RAB29 PM20D1 SLC41A1 NUCKS1 SLC26A9 GC01M205795 LOC105371702
GH01G205840 0.9 dbSUPER 11.2 -28.2 -28177 3.3 HDAC1 YBX3 PTBP1 PKNOX1 ARNT ZBTB40 RAD21 YY1 ZNF335 TCF12 PM20D1 RAB29 MAPKAPK2 SLC41A1 SLC26A9
GH01G205789 0.6 dbSUPER 12 +24.1 24111 1.2 ZNF579 ZNF121 PKNOX1 GATA3 NFIB FOS PM20D1 SLC41A1 SLC26A9 NUCKS1 RAB29 GC01M205795 LOC105371702
GH01G205784 0.6 dbSUPER 12 +28.3 28345 1.0 BCOR ESRRA PKNOX1 NR2F1 PBX2 ZMYM3 TEAD3 PM20D1 SLC41A1 NUCKS1 SLC26A9 LOC105371702 GC01M205795
GH01G205852 0.6 ENCODE 11.1 -38.4 -38409 0.1 CTBP1 GATA3 CUX1 RCOR1 ATF2 SP7 SLC41A1 RAB29 PM20D1 LOC284581
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC41A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLC41A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SLC41A1 Gene

205,789,093 bp from pter
205,813,759 bp from pter
24,667 bases
Minus strand

Genomic View for SLC41A1 Gene

Genes around SLC41A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC41A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC41A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC41A1 Gene

Proteins for SLC41A1 Gene

  • Protein details for SLC41A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 41 member 1
    Protein Accession:
    Secondary Accessions:
    • Q63HJ4
    • Q658Z5
    • Q659A4
    • Q6MZK2

    Protein attributes for SLC41A1 Gene

    513 amino acids
    Molecular mass:
    54901 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC41A1 Gene

Post-translational modifications for SLC41A1 Gene

  • Ubiquitination at Lys170
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC41A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC41A1 Gene

Domains & Families for SLC41A1 Gene

Gene Families for SLC41A1 Gene


Protein Domains for SLC41A1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLC41A transporter family.
  • Belongs to the SLC41A transporter family.
genes like me logo Genes that share domains with SLC41A1: view

Function for SLC41A1 Gene

Molecular function for SLC41A1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a magnesium transporter that is responsive to magnesium balance.

Gene Ontology (GO) - Molecular Function for SLC41A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008324 cation transmembrane transporter activity IEA --
GO:0015095 magnesium ion transmembrane transporter activity TAS --
GO:0022892 substrate-specific transporter activity IMP 22031603
GO:0061768 magnesium:sodium antiporter activity IMP 22031603
GO:0072509 divalent inorganic cation transmembrane transporter activity ISS --
genes like me logo Genes that share ontologies with SLC41A1: view
genes like me logo Genes that share phenotypes with SLC41A1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC41A1 Gene

Localization for SLC41A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC41A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC41A1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC41A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IDA 23661805
GO:0043234 protein complex IDA 18367447
genes like me logo Genes that share ontologies with SLC41A1: view

Pathways & Interactions for SLC41A1 Gene

genes like me logo Genes that share pathways with SLC41A1: view

Interacting Proteins for SLC41A1 Gene

Gene Ontology (GO) - Biological Process for SLC41A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0010961 cellular magnesium ion homeostasis IMP 22031603
GO:0015693 magnesium ion transport IMP 22031603
genes like me logo Genes that share ontologies with SLC41A1: view

No data available for SIGNOR curated interactions for SLC41A1 Gene

Drugs & Compounds for SLC41A1 Gene

(1) Drugs for SLC41A1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with SLC41A1: view

Transcripts for SLC41A1 Gene

Unigene Clusters for SLC41A1 Gene

Solute carrier family 41, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC41A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2: - - - -
SP3: -

Relevant External Links for SLC41A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC41A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC41A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC41A1 Gene

This gene is overexpressed in Heart - Left Ventricle (x8.9) and Heart - Atrial Appendage (x4.9).

Protein differential expression in normal tissues from HIPED for SLC41A1 Gene

This gene is overexpressed in Nasal epithelium (58.2) and Breast (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC41A1 Gene

Protein tissue co-expression partners for SLC41A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC41A1 Gene:


SOURCE GeneReport for Unigene cluster for SLC41A1 Gene:


mRNA Expression by UniProt/SwissProt for SLC41A1 Gene:

Tissue specificity: Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen.

Evidence on tissue expression from TISSUES for SLC41A1 Gene

  • Muscle(4.4)
  • Nervous system(2.9)
  • Heart(2.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with SLC41A1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC41A1 Gene

Orthologs for SLC41A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC41A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC41A1 34 35
  • 99.74 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 98 (a)
-- 35
  • 85 (a)
(Monodelphis domestica)
Mammalia SLC41A1 35
  • 95 (a)
(Canis familiaris)
Mammalia SLC41A1 34 35
  • 93.5 (n)
(Rattus norvegicus)
Mammalia Slc41a1 34
  • 92.2 (n)
(Mus musculus)
Mammalia Slc41a1 34 16 35
  • 91.73 (n)
(Bos Taurus)
Mammalia SLC41A1 34 35
  • 90.38 (n)
(Gallus gallus)
Aves SLC41A1 34 35
  • 78.88 (n)
(Anolis carolinensis)
Reptilia SLC41A1 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc41a1 34
  • 70.7 (n)
Str.15281 34
(Danio rerio)
Actinopterygii slc41a1 34 35
  • 74.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33181 35
  • 29 (a)
(Caenorhabditis elegans)
Secernentea K07H8.2 34 35
  • 52.61 (n)
ZK185.2 35
  • 34 (a)
ZK1053.6 35
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 57 (a)
Species where no ortholog for SLC41A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC41A1 Gene

Gene Tree for SLC41A1 (if available)
Gene Tree for SLC41A1 (if available)

Paralogs for SLC41A1 Gene

Paralogs for SLC41A1 Gene

(2) SIMAP similar genes for SLC41A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC41A1: view

Variants for SLC41A1 Gene

Sequence variations from dbSNP and Humsavar for SLC41A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000380156 -- 205,811,763(+) GTTAC(A/G)AAGAG intron-variant
rs1000432259 -- 205,811,374(+) GCTGT(A/G)CAGAA intron-variant
rs1000715233 -- 205,813,213(+) CCCCC(A/C/G)CGCTC intron-variant, upstream-variant-2KB
rs1000894599 -- 205,807,138(+) CATCC(C/T)GCTCT intron-variant
rs1000898862 -- 205,807,816(+) CATGC(-/CTGA)CTATT intron-variant

Variation tolerance for SLC41A1 Gene

Residual Variation Intolerance Score: 8.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC41A1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC41A1 Gene

Disorders for SLC41A1 Gene

Relevant External Links for SLC41A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC41A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC41A1 Gene

Publications for SLC41A1 Gene

  1. The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. (PMID: 12810078) Wabakken T. … Aasheim H.-C. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 22 64
  2. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. (PMID: 21738487) Do C.B. … Eriksson N. (PLoS Genet. 2011) 3 46 64
  3. Genetic variability at the PARK16 locus. (PMID: 20683486) Tucci A. … PaisA!n-Ruiz C. (Eur. J. Hum. Genet. 2010) 3 46 64
  4. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. (PMID: 19915576) Satake W. … Toda T. (Nat. Genet. 2009) 3 46 64
  5. SLC41A1 is a novel mammalian Mg2+ carrier. (PMID: 18367447) Kolisek M. … Schweigel M. (J. Biol. Chem. 2008) 2 3 64

Products for SLC41A1 Gene

Sources for SLC41A1 Gene

Loading form....