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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC41A1 Gene

protein-coding   GIFtS: 51
GCID: GC01M205758

solute carrier family 41, member 1

 Explore 4 diseases affiliated with
SLC41A1 via our new
 Human Malady Compendium 
Biological research products
for SLC41A1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 41, Member 11 2
MgtE1 2
Solute Carrier Family 41 Member 12

External Ids:    HGNC: 194291   Entrez Gene: 2544282   Ensembl: ENSG000001330657   OMIM: 6108015   UniProtKB: Q8IVJ13   

Export aliases for SLC41A1 gene to outside databases

Previous GC identifers: GC01M201219 GC01M202119 GC01M202935 GC01M202489 GC01M204025 GC01M176922


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: S41A1_HUMAN, Q8IVJ1
Function: Acts as a magnesium transporter that is responsive to magnesium balance




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC41A1 gene promoter:
         Egr-3   STAT1   Tal-1   STAT1beta   E47   STAT1alpha   CBF-A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC41A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC41A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC41A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

SLC41A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC41A1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M205758:  view genomic region     (about GC identifiers)

Start:
205,758,221 bp from pter      End:
205,782,876 bp from pter
Size:
24,656 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S41A1_HUMAN, Q8IVJ1 (See protein sequence)
Recommended Name: Solute carrier family 41 member 1  
Size: 513 amino acids; 54901 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q63HJ4 Q658Z5 Q659A4 Q6MZK2

Explore the universe of human proteins at neXtProt for SLC41A1: NX_Q8IVJ1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IVJ1

  • SLC41A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_776253.3  
    ENSEMBL proteins: 
     ENSP00000356105  
    Reactome Protein details: Q8IVJ1
    Human Recombinant Protein Products: 
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    Uscn Proteins for SLC41A1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    SLC41A1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC41A1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006667 MgtE_Mg_transptr_membr

    Graphical View of Domain Structure for InterPro Entry Q8IVJ1

    ProtoNet protein and cluster: Q8IVJ1

    UniProtKB/Swiss-Prot: S41A1_HUMAN, Q8IVJ1
    Similarity: Belongs to the SLC41A transporter family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: S41A1_HUMAN, Q8IVJ1
    Function: Acts as a magnesium transporter that is responsive to magnesium balance

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008324cation transmembrane transporter activity IEA--


    SLC41A1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport1.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    2Zinc transporters
    Metal ion SLC transporters0.68

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SLC41A1
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Metal ion SLC transporters



    SLC41A1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC41A1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC41A1 (ENSP000003561054) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055085transmembrane transport TAS--


    SLC41A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC41A1

    1 HMDB Compound for SLC41A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about SLC41A1 / S41A1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC41A1 gene: 
    NM_173854.4  

    Unigene Cluster for SLC41A1:

    Solute carrier family 41, member 1
    Hs.20274  [show with all ESTs]
    Unigene Representative Sequence: BX648979
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367137(uc001hdg.1 uc001hdh.1) ENST00000468057 ENST00000484228
    ENST00000484000

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    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC41A1 (see all 54):
    hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-4254 hsa-miR-106a hsa-miR-219-5p hsa-miR-650 hsa-miR-371-5p hsa-miR-519a
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    Additional cDNA sequence: 

    AJ514402.1 AK092123.1 AK125075.1 AK128069.1 AK314732.1 AL831974.1 AL832001.1 AL832362.1 
    BC136303.1 BX641054.1 BX648979.1 

    8 DOTS entries:

    DT.442034  DT.100784460  DT.101984204  DT.121367732  DT.100025762  DT.100736660  DT.121367752  DT.91704126 

    24/137 AceView cDNA sequences (see all 137):

    AA278332 AA767685 AI366046 AW873528 CB044418 AA603046 AA280164 BM817551 
    BU620186 AI983661 AW294649 AJ571738 BQ949970 CD672809 AL041552 BQ706265 
    BM783173 AL832001 BU726174 BM665672 AK128069 AA135456 BM479231 BQ221659 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC41A1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
    SP1:                                                                                -                           
    SP2:                    -     -     -                                               -                           
    SP3:                                -                                                                           
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for SLC41A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC41A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACTTTTGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SLC41A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleExtraocular MusclesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC41A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC41A1

    SOURCE GeneReport for Unigene cluster: Hs.20274

    UniProtKB/Swiss-Prot: S41A1_HUMAN, Q8IVJ1
    Tissue specificity: Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal
    gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC41A1 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLC41A11 solute carrier family 41, member 1 78.88(n)
    86.94(a)
      419837  XM_417968.3  XP_417968.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC41A16
    --
    85(a)
    1 ↔ 1
    GL343228.1(674356-710381)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX851794.12   -- 76.66(n)    BX851794.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570586332   -- 74.5(n)    57058633 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG331816
    --
    29(a)
    1 → many
    X(8383381-8411062)
    worm
    (Caenorhabditis elegans)
    Secernentea K07H8.21 Protein K07H8.2 53.05(n)
    50.81(a)
      177623  NM_068993.2  NP_501394.1 


    ENSEMBL Gene Tree for SLC41A1 (if available)
    TreeFam Gene Tree for SLC41A1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC41A1 gene
    SLC41A32  SLC41A22  
    2 SIMAP similar genes for SLC41A1 using alignment to 2 protein entries:     S41A1_HUMAN (see all proteins):
    SLC41A2    SLC41A3

    SLC41A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/394 NCBI SNPs in SLC41A1 are shown (see all 394    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901639211,2
    --205757768(+) TTTCTA/GTCACA 1 -- ds50010--------
    rs1445039951,2
    --205757796(+) GTTTC-/TTTCTTTT 1 -- ds50010--------
    rs2000005741,2
    --205757799(+) TGTTT-/CCTTTT 1 -- ds50010--------
    rs127474751,2
    C,F,H,--205757800(+) GTTTCT/CTTTTT 1 -- ds500111Minor allele frequency- C:0.50NS EA 1664
    rs17751481,2
    C,F,A,--205757824(+) AGTCTC/TGTTCT 1 -- ds50013Minor allele frequency- T:0.09MN WA NA 188
    rs1131555231,2
    C,--205757897(+) AAGTGG/ATTCTC 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1385711261,2
    --205757949(+) CACCAC/TACCTG 1 -- ds50010--------
    rs1812599841,2
    --205757960(+) ACTAAC/TTTTTG 1 -- ds50010--------
    rs1853208341,2
    --205758034(+) GATCCG/TCCCGC 1 -- ds50010--------
    rs1881864451,2
    --205758050(+) CCTCCC/TAAAGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC41A1 (205758221 - 205782876 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC41A1: --
    Human Gene Mutation Database (HGMD): SLC41A1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC41A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC41A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC41A1 for disorders           About GeneDecksing

    OMIM gene information: 610801    OMIM disorders: --

    4 diseases for SLC41A1:    About MalaCards
    azoospermia    parkinson's disease    thyroiditis    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: SLC41A1 (1 document)

    Export disorders for SLC41A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC41A1 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with SLC41A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. (PubMed id 12810078)1, 2, 3, 9 Wabakken T.... Aasheim H.-C. (2003)
    2. SLC41A1 is a novel mammalian Mg2+ carrier. (PubMed id 18367447)1, 3 Kolisek M....Schweigel M. (2008)
    3. Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters. (PubMed id 15713785)1, 2 Goytain A. and Quamme G.A. (2005)
    4. Human gene SLC41A1 encodes for the Na+/MgA^+ exchanger . (PubMed id 22031603)1 Kolisek M....Schweigel-RAPntgen M. (2012)
    5. Web-based genome-wide association study identifies tw o novel loci and a substantial genetic component for Parkinson's disease. (PubMed id 21738487)1 Do C.B....Eriksson N. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Genetic variants in the RAB7L1 and SLC41A1 genes of th e PARK16 locus in Chinese Parkinson's disease patients. (PubMed id 21812739)1 Yan Y....Zhang B. (2011)
    8. SLC41A1 Mg(2+) transport is regulated via Mg(2+)-depe ndent endosomal recycling through its N-terminal cytoplasmic domain. (PubMed id 21696366)1 Mandt T....Sahni J. (2011)
    9. Genetic variability at the PARK16 locus. (PubMed id 20683486)1 Tucci A....PaisA!n-Ruiz C. (2010)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 254428 HGNC: 19429 AceView: SLC41A1 Ensembl:ENSG00000133065 euGenes: HUgn254428
    ECgene: SLC41A1 H-InvDB: SLC41A1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
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