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Aliases for SLC41A1 Gene

Aliases for SLC41A1 Gene

  • Solute Carrier Family 41 Member 1 2 3
  • Solute Carrier Family 41 (Magnesium Transporter), Member 1 2 3 5
  • Solute Carrier Family 41, Member 1 3
  • MgtE 3

External Ids for SLC41A1 Gene

Previous GeneCards Identifiers for SLC41A1 Gene

  • GC01M201219
  • GC01M202119
  • GC01M202935
  • GC01M202489
  • GC01M204025
  • GC01M205758
  • GC01M176922

Summaries for SLC41A1 Gene

GeneCards Summary for SLC41A1 Gene

SLC41A1 (Solute Carrier Family 41 Member 1) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC41A2.

UniProtKB/Swiss-Prot for SLC41A1 Gene

  • Acts as a magnesium transporter that is responsive to magnesium balance.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC41A1 Gene

Genomics for SLC41A1 Gene

Regulatory Elements for SLC41A1 Gene

Enhancers for SLC41A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC41A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLC41A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC41A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC41A1 Gene

Chromosome:
1
Start:
205,789,093 bp from pter
End:
205,813,759 bp from pter
Size:
24,667 bases
Orientation:
Minus strand

Genomic View for SLC41A1 Gene

Genes around SLC41A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC41A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC41A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC41A1 Gene

Proteins for SLC41A1 Gene

  • Protein details for SLC41A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVJ1-S41A1_HUMAN
    Recommended name:
    Solute carrier family 41 member 1
    Protein Accession:
    Q8IVJ1
    Secondary Accessions:
    • Q63HJ4
    • Q658Z5
    • Q659A4
    • Q6MZK2

    Protein attributes for SLC41A1 Gene

    Size:
    513 amino acids
    Molecular mass:
    54901 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC41A1 Gene

Proteomics data for SLC41A1 Gene at MOPED

Post-translational modifications for SLC41A1 Gene

  • Ubiquitination at Lys 170
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC41A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC41A1 Gene

Domains & Families for SLC41A1 Gene

Gene Families for SLC41A1 Gene

HGNC:
IUPHAR :

Protein Domains for SLC41A1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IVJ1

UniProtKB/Swiss-Prot:

S41A1_HUMAN :
  • Belongs to the SLC41A transporter family.
Family:
  • Belongs to the SLC41A transporter family.
genes like me logo Genes that share domains with SLC41A1: view

Function for SLC41A1 Gene

Molecular function for SLC41A1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a magnesium transporter that is responsive to magnesium balance.
genes like me logo Genes that share phenotypes with SLC41A1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC41A1 Gene

Localization for SLC41A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC41A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC41A1 Gene COMPARTMENTS Subcellular localization image for SLC41A1 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SLC41A1 Gene

Pathways & Interactions for SLC41A1 Gene

genes like me logo Genes that share pathways with SLC41A1: view

Interacting Proteins for SLC41A1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356105%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000356105 for SLC41A1 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC41A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport IEA --
GO:0055085 transmembrane transport IBA,TAS --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC41A1: view

No data available for SIGNOR curated interactions for SLC41A1 Gene

Drugs & Compounds for SLC41A1 Gene

(1) Drugs for SLC41A1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with SLC41A1: view

Transcripts for SLC41A1 Gene

Unigene Clusters for SLC41A1 Gene

Solute carrier family 41, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC41A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for SLC41A1 Gene

GeneLoc Exon Structure for
SLC41A1
ECgene alternative splicing isoforms for
SLC41A1

Expression for SLC41A1 Gene

mRNA expression in normal human tissues for SLC41A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC41A1 Gene

This gene is overexpressed in Heart - Left Ventricle (x8.9) and Heart - Atrial Appendage (x4.9).

Protein differential expression in normal tissues from HIPED for SLC41A1 Gene

This gene is overexpressed in Nasal epithelium (58.2) and Breast (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC41A1 Gene



SOURCE GeneReport for Unigene cluster for SLC41A1 Gene Hs.20274

mRNA Expression by UniProt/SwissProt for SLC41A1 Gene

Q8IVJ1-S41A1_HUMAN
Tissue specificity: Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen.
genes like me logo Genes that share expression patterns with SLC41A1: view

Protein tissue co-expression partners for SLC41A1 Gene

Primer Products

Orthologs for SLC41A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC41A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC41A1 35
  • 90.38 (n)
  • 96.69 (a)
SLC41A1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC41A1 35
  • 93.5 (n)
  • 98.25 (a)
SLC41A1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc41a1 35
  • 91.73 (n)
  • 97.85 (a)
Slc41a1 16
Slc41a1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC41A1 35
  • 99.74 (n)
  • 100 (a)
SLC41A1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc41a1 35
  • 92.2 (n)
  • 98.05 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC41A1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC41A1 35
  • 78.88 (n)
  • 86.94 (a)
SLC41A1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC41A1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc41a1 35
  • 70.7 (n)
  • 78.17 (a)
Str.15281 35
zebrafish
(Danio rerio)
Actinopterygii slc41a1 35
  • 74.13 (n)
  • 80.96 (a)
slc41a1 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33181 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K07H8.2 35
  • 52.61 (n)
  • 49.88 (a)
K07H8.2 36
  • 43 (a)
ManyToMany
ZK1053.6 36
  • 25 (a)
ManyToMany
ZK185.2 36
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToMany
Species with no ortholog for SLC41A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC41A1 Gene

ENSEMBL:
Gene Tree for SLC41A1 (if available)
TreeFam:
Gene Tree for SLC41A1 (if available)

Paralogs for SLC41A1 Gene

Paralogs for SLC41A1 Gene

(2) SIMAP similar genes for SLC41A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC41A1: view

Variants for SLC41A1 Gene

Sequence variations from dbSNP and Humsavar for SLC41A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2224 -- 205,800,423(+) GGCCC(A/G)GAATC intron-variant
rs708726 -- 205,793,011(-) TGAAG(A/C)GTCAT intron-variant
rs708727 -- 205,798,757(+) GCCAC(A/G)TTGTC reference, synonymous-codon
rs708729 -- 205,804,333(+) GCATA(C/T)GCTTG intron-variant
rs708730 -- 205,808,652(+) GTCCC(A/G)GCCCT intron-variant

Variation tolerance for SLC41A1 Gene

Residual Variation Intolerance Score: 8.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC41A1 Gene

Human Gene Mutation Database (HGMD)
SLC41A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC41A1 Gene

Disorders for SLC41A1 Gene

Relevant External Links for SLC41A1

Genetic Association Database (GAD)
SLC41A1
Human Genome Epidemiology (HuGE) Navigator
SLC41A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC41A1

No disorders were found for SLC41A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC41A1 Gene

Publications for SLC41A1 Gene

  1. The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. (PMID: 12810078) Wabakken T. … Aasheim H.-C. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23 67
  2. SLC41A1 is a novel mammalian Mg2+ carrier. (PMID: 18367447) Kolisek M. … Schweigel M. (J. Biol. Chem. 2008) 2 3
  3. Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies. (PMID: 25434496) Kim S. … Jee S.H. (Gene 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Insulin Modulates the Na+/Mg2+ Exchanger SLC41A1 and Influences Mg2+ Efflux from Intracellular Stores in Transgenic HEK293 Cells. (PMID: 26355001) Mastrototaro L. … Kolisek M. (J. Nutr. 2015) 3

Products for SLC41A1 Gene

Sources for SLC41A1 Gene

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