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Aliases for SLC41A1 Gene

Aliases for SLC41A1 Gene

  • Solute Carrier Family 41 (Magnesium Transporter), Member 1 2 3
  • Solute Carrier Family 41, Member 1 3
  • Solute Carrier Family 41 Member 1 3
  • MgtE 3

External Ids for SLC41A1 Gene

Summaries for SLC41A1 Gene

GeneCards Summary for SLC41A1 Gene

SLC41A1 (Solute Carrier Family 41 (Magnesium Transporter), Member 1) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC41A2.

UniProtKB/Swiss-Prot for SLC41A1 Gene

  • Acts as a magnesium transporter that is responsive to magnesium balance.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC41A1 Gene

Genomics for SLC41A1 Gene

Genomic Location for SLC41A1 Gene

Start:
205,789,093 bp from pter
End:
205,813,759 bp from pter
Size:
24,667 bases
Orientation:
Minus strand

Genomic View for SLC41A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC41A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC41A1 Gene

Regulatory Elements for SLC41A1 Gene

Proteins for SLC41A1 Gene

  • Protein details for SLC41A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVJ1-S41A1_HUMAN
    Recommended name:
    Solute carrier family 41 member 1
    Protein Accession:
    Q8IVJ1
    Secondary Accessions:
    • Q63HJ4
    • Q658Z5
    • Q659A4
    • Q6MZK2

    Protein attributes for SLC41A1 Gene

    Size:
    513 amino acids
    Molecular mass:
    54901 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC41A1 Gene

Proteomics data for SLC41A1 Gene at MOPED

Post-translational modifications for SLC41A1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys170

Other Protein References for SLC41A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC41A1 Gene

Domains for SLC41A1 Gene

Gene Families for SLC41A1 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC41A1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

S41A1_HUMAN
Family:
  • Belongs to the SLC41A transporter family.:
    • Q8IVJ1
genes like me logo Genes that share domains with SLC41A1: view

Function for SLC41A1 Gene

Molecular function for SLC41A1 Gene

UniProtKB/Swiss-Prot Function: Acts as a magnesium transporter that is responsive to magnesium balance.

Gene Ontology (GO) - Molecular Function for SLC41A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008324 cation transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC41A1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC41A1 Gene

Localization for SLC41A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC41A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC41A1 Gene COMPARTMENTS Subcellular localization image for SLC41A1 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC41A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC41A1: view

Pathways for SLC41A1 Gene

genes like me logo Genes that share pathways with SLC41A1: view

Interacting Proteins for SLC41A1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356105%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000356105 for SLC41A1 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC41A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0055085 transmembrane transport TAS --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC41A1: view

Compounds for SLC41A1 Gene

(1) HMDB Compounds for SLC41A1 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with SLC41A1: view

Transcripts for SLC41A1 Gene

Unigene Clusters for SLC41A1 Gene

Solute carrier family 41, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC41A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for SLC41A1 Gene

GeneLoc Exon Structure for
SLC41A1
ECgene alternative splicing isoforms for
SLC41A1

Expression for SLC41A1 Gene

mRNA expression in normal human tissues for SLC41A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC41A1 Gene

This gene is overexpressed in Heart - Left Ventricle (8.9) and Heart - Atrial Appendage (4.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC41A1 Gene

SOURCE GeneReport for Unigene cluster for SLC41A1 Gene Hs.20274

mRNA Expression by UniProt/SwissProt for SLC41A1 Gene

Q8IVJ1-S41A1_HUMAN
Tissue specificity: Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen.
genes like me logo Genes that share expressions with SLC41A1: view

Orthologs for SLC41A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC41A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC41A1 36
  • 99.74 (n)
  • 100 (a)
SLC41A1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC41A1 36
  • 90.38 (n)
  • 96.69 (a)
SLC41A1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC41A1 36
  • 93.5 (n)
  • 98.25 (a)
SLC41A1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc41a1 36
  • 91.73 (n)
  • 97.85 (a)
Slc41a1 16
Slc41a1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC41A1 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 85 (a)
OneToMany
-- 37
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc41a1 36
  • 92.2 (n)
  • 98.05 (a)
chicken
(Gallus gallus)
Aves SLC41A1 36
  • 78.88 (n)
  • 86.94 (a)
SLC41A1 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC41A1 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc41a1 36
  • 70.7 (n)
  • 78.17 (a)
Str.15281 36
zebrafish
(Danio rerio)
Actinopterygii slc41a1 36
  • 74.13 (n)
  • 80.96 (a)
slc41a1 37
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33181 37
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K07H8.2 36
  • 52.61 (n)
  • 49.88 (a)
K07H8.2 37
  • 43 (a)
ManyToMany
ZK1053.6 37
  • 25 (a)
ManyToMany
ZK185.2 37
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 57 (a)
OneToMany
Species with no ortholog for SLC41A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC41A1 Gene

ENSEMBL:
Gene Tree for SLC41A1 (if available)
TreeFam:
Gene Tree for SLC41A1 (if available)

Paralogs for SLC41A1 Gene

Paralogs for SLC41A1 Gene

Selected SIMAP similar genes for SLC41A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC41A1: view

Variants for SLC41A1 Gene

Sequence variations from dbSNP and Humsavar for SLC41A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2224 -- 205,800,423(+) GGCCC(A/G)GAATC intron-variant
rs708726 -- 205,793,011(-) TGAAG(A/C)GTCAT intron-variant
rs708727 -- 205,798,757(+) GCCAC(A/G)TTGTC reference, synonymous-codon
rs708729 -- 205,804,333(+) GCATA(C/T)GCTTG intron-variant
rs708730 -- 205,808,652(+) GTCCC(A/G)GCCCT intron-variant

Relevant External Links for SLC41A1 Gene

HapMap Linkage Disequilibrium report
SLC41A1
Human Gene Mutation Database (HGMD)
SLC41A1

No data available for Structural Variations from Database of Genomic Variants (DGV) for SLC41A1 Gene

Disorders for SLC41A1 Gene

Relevant External Links for SLC41A1

Genetic Association Database (GAD)
SLC41A1
Human Genome Epidemiology (HuGE) Navigator
SLC41A1
genes like me logo Genes that share disorders with SLC41A1: view

No data available for UniProtKB/Swiss-Prot for SLC41A1 Gene

Publications for SLC41A1 Gene

  1. The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. (PMID: 12810078) Wabakken T. … Aasheim H.-C. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23
  2. Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters. (PMID: 15713785) Goytain A. … Quamme G.A. (Physiol. Genomics 2005) 3 4
  3. SLC41A1 is a novel mammalian Mg2+ carrier. (PMID: 18367447) Kolisek M. … Schweigel M. (J. Biol. Chem. 2008) 2 3
  4. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. (PMID: 19915576) Satake W. … Toda T. (Nat. Genet. 2009) 3 49
  5. Genetic variability at the PARK16 locus. (PMID: 20683486) Tucci A. … PaisA!n-Ruiz C. (Eur. J. Hum. Genet. 2010) 3 49

Products for SLC41A1 Gene

  • antibodies-online peptides for SLC41A1
  • antibodies-online antibodies for SLC41A1
  • antibodies-online kits for SLC41A1

Sources for SLC41A1 Gene

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