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Aliases for SLC39A9 Gene

Aliases for SLC39A9 Gene

  • Solute Carrier Family 39 Member 9 2 3 4 5
  • Zrt- And Irt-Like Protein 9 3 4
  • ZIP-9 3 4
  • ZIP9 3 4
  • Solute Carrier Family 39 (Zinc Transporter), Member 9 3
  • Solute Carrier Family 39, Member 9 2
  • Zinc Transporter SLC39A9 3
  • Zinc Transporter ZIP9 3

External Ids for SLC39A9 Gene

Previous GeneCards Identifiers for SLC39A9 Gene

  • GC00U913003
  • GC14P067856
  • GC14P067857
  • GC14P068935
  • GC14P069865
  • GC14P050033

Summaries for SLC39A9 Gene

GeneCards Summary for SLC39A9 Gene

SLC39A9 (Solute Carrier Family 39 Member 9) is a Protein Coding gene. GO annotations related to this gene include metal ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC39A9 Gene

  • May act as a zinc-influx transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A9 Gene

Genomics for SLC39A9 Gene

Regulatory Elements for SLC39A9 Gene

Enhancers for SLC39A9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F068961 1.6 FANTOM5 Ensembl ENCODE 11.1 -430.6 -430626 12.0 PKNOX1 ARID4B GLI4 ZNF48 YY1 GLIS2 FOS ZNF263 SP5 REST SLC39A9 ACTN1-AS1 HMGN1P3 DCAF5 ACTN1 GC14P068937
GH14F069267 0.9 Ensembl ENCODE 10.3 -129.5 -129531 2.6 YBX1 GLI4 CDC5L ZKSCAN1 ZNF592 ZNF664 NONO CTBP1 TARDBP ZNF207 SLC39A9 ERH GALNT16 ACTN1 ENSG00000258520 GC14M069298
GH14F069464 0.8 Ensembl ENCODE 10.9 +66.9 66935 1.5 JUND JUN SIN3A FOS ZIC2 GALNT16 SLC39A9 ERH SRSF5 SMOC1 PLEKHD1
GH14F069460 0.8 ENCODE 10.9 +62.3 62274 0.2 ELF3 CTCF ATF1 PKNOX1 JUN BRCA1 RAD21 RFX5 GATA3 ZNF143 PLEKHD1 GALNT16 SLC39A9 ERH
GH14F069423 0.7 ENCODE 11.7 +26.5 26506 1.2 SOX13 GATAD2A CTCF SAP130 TEAD1 FOXA3 HMG20A PPARG FOXA1 GATA3 GALNT16 ERH SLC39A9 PLEKHD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC39A9 on UCSC Golden Path with GeneCards custom track

Promoters for SLC39A9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001458460 1685 5400 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207

Genomic Location for SLC39A9 Gene

Chromosome:
14
Start:
69,398,015 bp from pter
End:
69,468,403 bp from pter
Size:
70,389 bases
Orientation:
Plus strand

Genomic View for SLC39A9 Gene

Genes around SLC39A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A9 Gene

Proteins for SLC39A9 Gene

  • Protein details for SLC39A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUM3-S39A9_HUMAN
    Recommended name:
    Zinc transporter ZIP9
    Protein Accession:
    Q9NUM3
    Secondary Accessions:
    • G3V5J8
    • Q53HN3
    • Q5MJQ0
    • Q6P2Q1
    • Q86WY2

    Protein attributes for SLC39A9 Gene

    Size:
    307 amino acids
    Molecular mass:
    32251 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC39A9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A9 Gene

Post-translational modifications for SLC39A9 Gene

  • Glycosylation at Asn 29 and Asn 241
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for SLC39A9

No data available for DME Specific Peptides for SLC39A9 Gene

Domains & Families for SLC39A9 Gene

Gene Families for SLC39A9 Gene

Protein Domains for SLC39A9 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NUM3

UniProtKB/Swiss-Prot:

S39A9_HUMAN :
  • Belongs to the ZIP transporter (TC 2.A.5) family.
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A9: view

Function for SLC39A9 Gene

Molecular function for SLC39A9 Gene

UniProtKB/Swiss-Prot Function:
May act as a zinc-influx transporter.

Gene Ontology (GO) - Molecular Function for SLC39A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A9: view

Phenotypes for SLC39A9 Gene

genes like me logo Genes that share phenotypes with SLC39A9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC39A9

miRNA for SLC39A9 Gene

miRTarBase miRNAs that target SLC39A9

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC39A9 Gene

Localization for SLC39A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC39A9 gene
Compartment Confidence
plasma membrane 4
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC39A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC39A9: view

Pathways & Interactions for SLC39A9 Gene

SuperPathways for SLC39A9 Gene

No Data Available

Interacting Proteins for SLC39A9 Gene

Gene Ontology (GO) - Biological Process for SLC39A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006829 zinc II ion transport IEA --
GO:0030001 metal ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC39A9: view

No data available for Pathways by source and SIGNOR curated interactions for SLC39A9 Gene

Transcripts for SLC39A9 Gene

Unigene Clusters for SLC39A9 Gene

Solute carrier family 39 (zinc transporter), member 9:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for SLC39A9 Gene

GeneLoc Exon Structure for
SLC39A9
ECgene alternative splicing isoforms for
SLC39A9

Expression for SLC39A9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC39A9 Gene

Protein differential expression in normal tissues from HIPED for SLC39A9 Gene

This gene is overexpressed in Lung (11.4), Frontal cortex (11.0), and Kidney (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC39A9 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC39A9 Gene:

SLC39A9

SOURCE GeneReport for Unigene cluster for SLC39A9 Gene:

Hs.432690
genes like me logo Genes that share expression patterns with SLC39A9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLC39A9 Gene

Orthologs for SLC39A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC39A9 34 35
  • 99.57 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC39A9 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC39A9 34 35
  • 93.16 (n)
rat
(Rattus norvegicus)
Mammalia Slc39a9 34
  • 91.95 (n)
cow
(Bos Taurus)
Mammalia SLC39A9 34 35
  • 91.42 (n)
mouse
(Mus musculus)
Mammalia Slc39a9 34 16 35
  • 89.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC39A9 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC39A9 34 35
  • 81.09 (n)
lizard
(Anolis carolinensis)
Reptilia SLC39A9 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a9 34
  • 74.04 (n)
Str.2106 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16284 34
zebrafish
(Danio rerio)
Actinopterygii slc39a9 34 35
  • 72.75 (n)
wufc56g12 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009188 34
  • 58.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2177 34 35
  • 57.85 (n)
worm
(Caenorhabditis elegans)
Secernentea T01D3.5 34 35
  • 54.3 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4940 34
Species where no ortholog for SLC39A9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A9 Gene

ENSEMBL:
Gene Tree for SLC39A9 (if available)
TreeFam:
Gene Tree for SLC39A9 (if available)

Paralogs for SLC39A9 Gene

No data available for Paralogs for SLC39A9 Gene

Variants for SLC39A9 Gene

Sequence variations from dbSNP and Humsavar for SLC39A9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10129186 -- 69,409,812(+) TGGGG(A/C)TAAAG intron-variant
rs10131464 -- 69,406,618(+) tggag(G/T)cggag intron-variant
rs10132626 -- 69,403,701(+) CTTTT(C/T)TTATT intron-variant
rs10137828 -- 69,452,473(+) acagg(C/T)gcccg intron-variant
rs10138313 -- 69,415,675(+) GCTAT(A/G)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A9 Gene

Variant ID Type Subtype PubMed ID
nsv564967 CNV gain 21841781
nsv526398 CNV loss 19592680
nsv456335 CNV gain 19166990
esv3634836 CNV gain 21293372
dgv1930n100 CNV gain 25217958

Variation tolerance for SLC39A9 Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC39A9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC39A9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A9 Gene

Disorders for SLC39A9 Gene

Relevant External Links for SLC39A9

Genetic Association Database (GAD)
SLC39A9
Human Genome Epidemiology (HuGE) Navigator
SLC39A9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC39A9

No disorders were found for SLC39A9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A9 Gene

Publications for SLC39A9 Gene

  1. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Expression Profile Analysis of Zinc Transporters (ZIP4, ZIP9, ZIP11, ZnT9) in Gliomas and their Correlation with IDH1 Mutation Status. (PMID: 25921144) Kang X. … Wang H.J. (Asian Pac. J. Cancer Prev. 2015) 3 64
  5. Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: II. Role of human ZIP9 in testosterone-induced prostate and breast cancer cell apoptosis. (PMID: 25014355) Thomas P. … Berg A.H. (Endocrinology 2014) 3 64

Products for SLC39A9 Gene

Sources for SLC39A9 Gene

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