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Aliases for SLC39A9 Gene

Aliases for SLC39A9 Gene

  • Solute Carrier Family 39, Member 9 2 3
  • Zrt- And Irt-Like Protein 9 3 4
  • ZIP-9 3 4
  • ZIP9 3 4
  • Solute Carrier Family 39 (Zinc Transporter), Member 9 3
  • Solute Carrier Family 39 Member 9 4
  • Zinc Transporter SLC39A9 3

External Ids for SLC39A9 Gene

Previous GeneCards Identifiers for SLC39A9 Gene

  • GC00U913003
  • GC14P067856
  • GC14P067857
  • GC14P068935
  • GC14P069865
  • GC14P050033

Summaries for SLC39A9 Gene

GeneCards Summary for SLC39A9 Gene

SLC39A9 (Solute Carrier Family 39, Member 9) is a Protein Coding gene. GO annotations related to this gene include metal ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC39A9 Gene

  • May act as a zinc-influx transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A9 Gene

Genomics for SLC39A9 Gene

Regulatory Elements for SLC39A9 Gene

Genomic Location for SLC39A9 Gene

Chromosome:
14
Start:
69,398,015 bp from pter
End:
69,468,403 bp from pter
Size:
70,389 bases
Orientation:
Plus strand

Genomic View for SLC39A9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC39A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A9 Gene

Proteins for SLC39A9 Gene

  • Protein details for SLC39A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUM3-S39A9_HUMAN
    Recommended name:
    Zinc transporter ZIP9
    Protein Accession:
    Q9NUM3
    Secondary Accessions:
    • G3V5J8
    • Q53HN3
    • Q5MJQ0
    • Q6P2Q1
    • Q86WY2

    Protein attributes for SLC39A9 Gene

    Size:
    307 amino acids
    Molecular mass:
    32251 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC39A9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A9 Gene

Proteomics data for SLC39A9 Gene at MOPED

Post-translational modifications for SLC39A9 Gene

  • Glycosylation at Asn 29 and Asn 241
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC39A9

No data available for DME Specific Peptides for SLC39A9 Gene

Domains & Families for SLC39A9 Gene

Gene Families for SLC39A9 Gene

Protein Domains for SLC39A9 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NUM3

UniProtKB/Swiss-Prot:

S39A9_HUMAN :
  • Belongs to the ZIP transporter (TC 2.A.5) family.
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A9: view

Function for SLC39A9 Gene

Molecular function for SLC39A9 Gene

UniProtKB/Swiss-Prot Function:
May act as a zinc-influx transporter.

Gene Ontology (GO) - Molecular Function for SLC39A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A9: view

Phenotypes for SLC39A9 Gene

GenomeRNAi human phenotypes for SLC39A9:
genes like me logo Genes that share phenotypes with SLC39A9: view

Animal Model Products

CRISPR Products

miRNA for SLC39A9 Gene

miRTarBase miRNAs that target SLC39A9

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC39A9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC39A9 Gene

Localization for SLC39A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC39A9 Gene COMPARTMENTS Subcellular localization image for SLC39A9 gene
Compartment Confidence
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SLC39A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC39A9: view

Pathways & Interactions for SLC39A9 Gene

SuperPathways for SLC39A9 Gene

No Data Available

Interacting Proteins for SLC39A9 Gene

Gene Ontology (GO) - Biological Process for SLC39A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006829 zinc II ion transport IEA --
GO:0030001 metal ion transport --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC39A9: view

No data available for Pathways by source and SIGNOR curated interactions for SLC39A9 Gene

Drugs & Compounds for SLC39A9 Gene

No Compound Related Data Available

Transcripts for SLC39A9 Gene

Unigene Clusters for SLC39A9 Gene

Solute carrier family 39 (zinc transporter), member 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC39A9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for SLC39A9 Gene

GeneLoc Exon Structure for
SLC39A9
ECgene alternative splicing isoforms for
SLC39A9

Expression for SLC39A9 Gene

mRNA expression in normal human tissues for SLC39A9 Gene

Protein differential expression in normal tissues from HIPED for SLC39A9 Gene

This gene is overexpressed in Lung (11.4), Frontal cortex (11.0), and Kidney (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SLC39A9 Gene



SOURCE GeneReport for Unigene cluster for SLC39A9 Gene Hs.432690

genes like me logo Genes that share expression patterns with SLC39A9: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC39A9 Gene

Orthologs for SLC39A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC39A9 35
  • 91.42 (n)
  • 95.11 (a)
SLC39A9 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC39A9 35
  • 93.16 (n)
  • 96.09 (a)
SLC39A9 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc39a9 35
  • 89.69 (n)
  • 93.49 (a)
Slc39a9 16
Slc39a9 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC39A9 35
  • 99.57 (n)
  • 100 (a)
SLC39A9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc39a9 35
  • 91.95 (n)
  • 95.47 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC39A9 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC39A9 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC39A9 35
  • 81.09 (n)
  • 90.82 (a)
SLC39A9 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC39A9 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a9 35
  • 74.04 (n)
  • 86.14 (a)
Str.2106 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16284 35
zebrafish
(Danio rerio)
Actinopterygii slc39a9 35
  • 72.75 (n)
  • 82.08 (a)
wufc56g12 35
slc39a9 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009188 35
  • 58.51 (n)
  • 60.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2177 35
  • 57.85 (n)
  • 56.88 (a)
CG2177 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T01D3.5 35
  • 54.3 (n)
  • 52.92 (a)
T01D3.5 36
  • 39 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4940 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for SLC39A9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A9 Gene

ENSEMBL:
Gene Tree for SLC39A9 (if available)
TreeFam:
Gene Tree for SLC39A9 (if available)

Paralogs for SLC39A9 Gene

No data available for Paralogs for SLC39A9 Gene

Variants for SLC39A9 Gene

Sequence variations from dbSNP and Humsavar for SLC39A9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7276 -- 69,462,226(+) GTTCA(A/G)TAGCT utr-variant-3-prime, intron-variant
rs1045301 -- 69,461,590(-) ACAGC(A/C)ACTCC utr-variant-3-prime, intron-variant
rs1045534 -- 69,462,323(+) TTTCC(A/C)CTTTA utr-variant-3-prime, intron-variant
rs1055622 -- 69,459,744(+) TCTTT(C/T)CTTTG utr-variant-3-prime, intron-variant
rs1055623 -- 69,459,780(+) CCTCT(C/T)CTCGC utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A9 Gene

Variant ID Type Subtype PubMed ID
nsv526398 CNV Loss 19592680
nsv456335 CNV Gain 19166990

Variation tolerance for SLC39A9 Gene

Residual Variation Intolerance Score: 46.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC39A9 Gene

HapMap Linkage Disequilibrium report
SLC39A9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A9 Gene

Disorders for SLC39A9 Gene

Relevant External Links for SLC39A9

Genetic Association Database (GAD)
SLC39A9
Human Genome Epidemiology (HuGE) Navigator
SLC39A9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC39A9
genes like me logo Genes that share disorders with SLC39A9: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A9 Gene

Publications for SLC39A9 Gene

  1. Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: II. Role of human ZIP9 in testosterone-induced prostate and breast cancer cell apoptosis. (PMID: 25014355) Thomas P. … Berg A.H. (Endocrinology 2014) 67
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  3. Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium. (PMID: 21696611) Chambers K.F. … Lang S.H. (J. Biomed. Sci. 2011) 67
  4. SLC39A9 (ZIP9) regulates zinc homeostasis in the secretory pathway: characterization of the ZIP subfamily I protein in vertebrate cells. (PMID: 19420709) Matsuura W. … Kambe T. (Biosci. Biotechnol. Biochem. 2009) 67
  5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 67

Products for SLC39A9 Gene

Sources for SLC39A9 Gene

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