SLC39A9 Gene
protein-coding GIFtS: 43
GCID: GC14P069865
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solute carrier family 39 (zinc transporter), member 9
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Aliases for SLC39A9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Solute Carrier Family 39 (Zinc Transporter), Member 91 2 | | FLJ112741 | | Zrt- And Irt-Like Protein 92 3 | | Zinc Transporter SLC39A92 | | ZIP-92 3 | | Zinc Transporter ZIP92 | | ZIP92 3 | | Solute Carrier Family 39 Member 93 |
Export aliases for SLC39A9 gene to outside databasesPrevious GC identifers: GC00U913003 GC14P067856 GC14P067857 GC14P068935 GC14P050033 |
Summaries for SLC39A9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: S39A9_HUMAN, Q9NUM3Function: May act as a zinc-influx transporter (By similarity)
|
Genomic Views for SLC39A9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SLC39A9 gene promoter: GR Pbx1a p300 C/EBPalpha AREB6 E2F-1 E2F HOXA5 GR-alpha Pax-4a Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC39A9
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC39A9 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q24.1 Ensembl cytogenetic band: 14q24.1 HGNC cytogenetic band: 14q24.1SLC39A9 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P069865: view genomic region
(about GC identifiers)
Start:
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69,864,732 bp from pter |
End:
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69,929,107 bp from pter |
Size:
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64,376 bases |
Orientation:
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plus strand |
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Proteins for SLC39A9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: S39A9_HUMAN, Q9NUM3 (See
protein sequence)Recommended Name: Zinc transporter ZIP9 Size: 307 amino acids; 32251 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q53HN3 Q5MJQ0 Q6P2Q1 Q86WY2Alternative splicing: 2 isoforms: Q9NUM3-1 Q9NUM3-2 Explore the universe of human proteins at neXtProt for SLC39A9: NX_Q9NUM3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NUM3 SLC39A9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001239077.1 NP_001239079.1 NP_001239080.1 NP_001239081.1 NP_060845.2 ENSEMBL proteins: ENSP00000452385 ENSP00000336887 ENSP00000450639 ENSP00000451833 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SLC39A9 for ontologies About GeneDecksing
SLC39A9 Antibody Products: Assay Products for SLC39A9: |
Protein
Domains / Families for SLC39A9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC39A9 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NUM3ProtoNet protein and cluster: Q9NUM3 1 Blocks protein family: IPB003689 Zinc transporter ZIP
UniProtKB/Swiss-Prot: S39A9_HUMAN, Q9NUM3Similarity: Belongs to the ZIP transporter (TC 2.A.5) family |
Function for SLC39A9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: S39A9_HUMAN, Q9NUM3Function: May act as a zinc-influx transporter (By similarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC39A9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC39A9 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC39A9 (NM_018375) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC39A9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC39A9  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A9 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046873 | metal ion transmembrane transporter activity |
IEA | -- |
SLC39A9 for ontologies About GeneDecksing
|
Pathways & Interactions for SLC39A9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC39A9
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006829 | zinc ion transport |
IEA | -- |
SLC39A9 for ontologies About GeneDecksing
|
Drugs & Compounds for SLC39A9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SLC39A9 Search CenterWatch for drugs/clinical trials and news about SLC39A9 / S39A9 
|
Transcripts for SLC39A9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SLC39A9 gene (5 alternative transcripts): NM_001252148.1 NM_001252150.1 NM_001252151.1 NM_001252152.1 NM_018375.4 Unigene Cluster for SLC39A9: Solute carrier family 39 (zinc transporter), member 9 Hs.432690 [show with all ESTs]Unigene Representative Sequence: NM_01837510 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000556125 ENST00000555245 ENST00000538956 ENST00000556605(uc001xlf.4) ENST00000336643 ENST00000031146(uc021rvg.1 uc021rvh.1 uc001xle.3 uc010aqx.3) ENST00000554059(uc001xld.4) ENST00000555840(uc001xlg.4) ENST00000557046 ENST00000554023
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC39A9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC39A9 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC39A9 (NM_018375) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC39A9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC39A9  |
Additional cDNA sequence: AK002136.1 AK025831.1 AK222547.1 AK293222.1 AK310285.1 AK311104.1 AK316381.1 AL137760.1 AY358687.1 AY780789.1 BC033301.1 BC062762.1 BC064383.1 FJ423549.1 16 DOTS entries: DT.100016675 DT.445513 DT.100669940 DT.100796024 DT.202590 DT.91741450 DT.91776263 DT.100641919 DT.100796022 DT.91976403 DT.101985095 DT.120778826 DT.95180833 DT.100807817 DT.120778701 DT.95259943 24/332 AceView cDNA sequences (see all 332): BM511926 BU688791 BU838531 AA348483 AI632932 AI160543 AW263931 BX387360 U92027 CA437962 AI554244 AK002136 BU620233 BM564478 AW771552 F05993 BX432587 BE048861 T40030 AW769118 BM512502 BM723898 CA413252 BE673623 GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A9 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for SLC39A9
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Expression for SLC39A9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC39A9 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GATGGCTGCC
About this image See SLC39A9 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SLC39A9
SOURCE GeneReport for Unigene cluster: Hs.432690 SABiosciences Custom PCR Arrays for SLC39A9
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC39A9 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC39A9 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC39A9 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC39A9 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A9 |
Orthologs for SLC39A9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SLC39A9 gene from 7/25 species (see all 25) About this table
ENSEMBL Gene Tree for SLC39A9 (if available) TreeFam Gene Tree for SLC39A9 (if available)  |
Paralogs for SLC39A9 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for SLC39A9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 14 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC39A9 (69864732 - 69929107 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SLC39A9: --  | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases for SLC39A9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC39A9 for disorders About GeneDecksing
1 disease for SLC39A9: About MalaCardsprostatitis Human Genome Epidemiology (HuGE) Navigator: SLC39A9 (1 document) Export disorders for SLC39A9 gene to outside databases
|
Publications for SLC39A9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC39A9 gene, integrated from 9 sources (see all 12): (articles sorted by number of sources associating them with SLC39A9) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium. (PubMed id 21696611)1 Chambers K.F....Lang S.H. (2011)
- SLC39A9 (ZIP9) regulates zinc homeostasis in the secr etory pathway: characterization of the ZIP subfamily I protein in vertebrate ce lls. (PubMed id 19420709)1 Matsuura W....Kambe T. (2009)
- Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571)1 Wang L....Thibodeau S.N. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for SLC39A9 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SLC39A9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC39A9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC39A9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SLC39A9 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLC39A9 gene: Search GeneIP for patents involving SLC39A9
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SLC39A9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC39A9 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC39A9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC39A9 | | OriGene Protein Over-expression Lysate for SLC39A9 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for SLC39A9 | | OriGene 3'-UTR Clone for SLC39A9 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC39A9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC39A9 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for SLC39A9 | | OriGene Custom Protein Services for SLC39A9 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC39A9 | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC39A9 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC39A9 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC39A9 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC39A9 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC39A9 |
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| | | Search Tocris compounds for SLC39A9 |
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 | | SLC39A9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A9 |
|  |  |  | | | ThermoFisher Antibodies for SLC39A9 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC39A9 |
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