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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC39A9 Gene

protein-coding   GIFtS: 43
GCID: GC14P069865

solute carrier family 39 (zinc transporter), member 9

 Explore 1 disease affiliated with
SLC39A9 via our new
 Human Malady Compendium 
Biological research products
for SLC39A9
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 91 2     FLJ112741
Zrt- And Irt-Like Protein 92 3     Zinc Transporter SLC39A92
ZIP-92 3     Zinc Transporter ZIP92
ZIP92 3     Solute Carrier Family 39 Member 93

External Ids:    HGNC: 201821   Entrez Gene: 553342   Ensembl: ENSG000000293647   UniProtKB: Q9NUM33   

Export aliases for SLC39A9 gene to outside databases

Previous GC identifers: GC00U913003 GC14P067856 GC14P067857 GC14P068935 GC14P050033


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: S39A9_HUMAN, Q9NUM3
Function: May act as a zinc-influx transporter (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC39A9 gene promoter:
         GR   Pbx1a   p300   C/EBPalpha   AREB6   E2F-1   E2F   HOXA5   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC39A9 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC39A9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC39A9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q24.1

SLC39A9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A9 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P069865:  view genomic region     (about GC identifiers)

Start:
69,864,732 bp from pter      End:
69,929,107 bp from pter
Size:
64,376 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S39A9_HUMAN, Q9NUM3 (See protein sequence)
Recommended Name: Zinc transporter ZIP9  
Size: 307 amino acids; 32251 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q53HN3 Q5MJQ0 Q6P2Q1 Q86WY2
Alternative splicing: 2 isoforms:  Q9NUM3-1   Q9NUM3-2   

Explore the universe of human proteins at neXtProt for SLC39A9: NX_Q9NUM3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NUM3

  • SLC39A9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001239077.1  NP_001239079.1  NP_001239080.1  NP_001239081.1  NP_060845.2  

    ENSEMBL proteins: 
     ENSP00000452385   ENSP00000336887   ENSP00000450639   ENSP00000451833  

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    Novus Biologicals SLC39A9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC39A9

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    SLC39A9 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC39A9 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003689 ZIP

    Graphical View of Domain Structure for InterPro Entry Q9NUM3

    ProtoNet protein and cluster: Q9NUM3

    1 Blocks protein family: IPB003689 Zinc transporter ZIP

    UniProtKB/Swiss-Prot: S39A9_HUMAN, Q9NUM3
    Similarity: Belongs to the ZIP transporter (TC 2.A.5) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: S39A9_HUMAN, Q9NUM3
    Function: May act as a zinc-influx transporter (By similarity)

    miRNA
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    hsa-miR-140-5p hsa-miR-106a hsa-miR-15a hsa-miR-218-1* hsa-miR-200a hsa-miR-138-2* hsa-miR-502-3p hsa-miR-93
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046873metal ion transmembrane transporter activity IEA--


    SLC39A9 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC39A9

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006829zinc ion transport IEA--


    SLC39A9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC39A9
    Search CenterWatch for drugs/clinical trials and news about SLC39A9 / S39A9 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC39A9 gene (5 alternative transcripts): 
    NM_001252148.1  NM_001252150.1  NM_001252151.1  NM_001252152.1  NM_018375.4  

    Unigene Cluster for SLC39A9:

    Solute carrier family 39 (zinc transporter), member 9
    Hs.432690  [show with all ESTs]
    Unigene Representative Sequence: NM_018375
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556125 ENST00000555245 ENST00000538956 ENST00000556605(uc001xlf.4)
    ENST00000336643 ENST00000031146(uc021rvg.1 uc021rvh.1 uc001xle.3 uc010aqx.3)
    ENST00000554059(uc001xld.4) ENST00000555840(uc001xlg.4) ENST00000557046
    ENST00000554023

    miRNA
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    8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC39A9 (see all 91):
    hsa-miR-140-5p hsa-miR-106a hsa-miR-15a hsa-miR-218-1* hsa-miR-200a hsa-miR-138-2* hsa-miR-502-3p hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidSLC39A9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC39A9 (see all 4)
    OriGene shRNA RFP: SLC39A9
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    Clone
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    Additional cDNA sequence: 

    AK002136.1 AK025831.1 AK222547.1 AK293222.1 AK310285.1 AK311104.1 AK316381.1 AL137760.1 
    AY358687.1 AY780789.1 BC033301.1 BC062762.1 BC064383.1 FJ423549.1 

    16 DOTS entries:

    DT.100016675  DT.445513  DT.100669940  DT.100796024  DT.202590  DT.91741450  DT.91776263  DT.100641919 
    DT.100796022  DT.91976403  DT.101985095  DT.120778826  DT.95180833  DT.100807817  DT.120778701  DT.95259943 

    24/332 AceView cDNA sequences (see all 332):

    BM511926 BU688791 BU838531 AA348483 AI632932 AI160543 AW263931 BX387360 
    U92027 CA437962 AI554244 AK002136 BU620233 BM564478 AW771552 F05993 
    BX432587 BE048861 T40030 AW769118 BM512502 BM723898 CA413252 BE673623 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A9    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:                          -                                   -               
    SP2:                          -                             -     -               
    SP3:                          -                                                   
    SP4:                                                                              


    ECgene alternative splicing isoforms for SLC39A9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC39A9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATGGCTGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SLC39A9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC39A9

    SOURCE GeneReport for Unigene cluster: Hs.432690
        SABiosciences Custom PCR Arrays for SLC39A9
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC39A9 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc39a91 , 5 solute carrier family 39 (zinc transporter), member more1, 5 89.69(n)1
    93.49(a)1
      12 (36.91 cM)5
    3281331  NM_026244.21  NP_080520.21 
     806442155 
    chicken
    (Gallus gallus)
    Aves SLC39A91 solute carrier family 39 (zinc transporter), member more 81.09(n)
    90.82(a)
      423261  NM_001007933.1  NP_001007934.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC39A96
    --
    90(a)
    1 ↔ 1
    GL343318.1(441524-464749)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.162842 Xenopus laevis transcribed sequence with moderate similarity more 74.78(n)    BU915251.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc56g122 wufc56g12 76.41(n)   325159  57055177 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG21771 CG2177 57.85(n)
    56.88(a)
      43786  NM_143662.1  NP_651919.2 
    worm
    (Caenorhabditis elegans)
    Secernentea T01D3.51 Protein T01D3.5 54.07(n)
    51.51(a)
      179862  NM_073992.3  NP_506393.1 


    ENSEMBL Gene Tree for SLC39A9 (if available)
    TreeFam Gene Tree for SLC39A9 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/985 NCBI SNPs in SLC39A9 are shown (see all 985    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37597701,2
    C,F,H,--69867080(+) ACAGAT/CGTTAA 5 -- int128Minor allele frequency- C:0.48EA NA NS WA CSA 3981
    rs1868405491,2
    --69867091(+) GCGAGG/TGTCCC 5 -- int10--------
    rs1381969291,2
    --69867117(+) TGAAAA/GCACTG 5 -- int10--------
    rs1916235111,2
    --69867142(+) TGATAA/GGTCCT 5 -- int10--------
    rs1141904371,2
    C,--69867310(+) AGGAGG/ACCTGA 5 -- int11Minor allele frequency- A:0.01WA 118
    rs1437673641,2
    --69867399(+) ATAGCC/TTGTGG 5 -- int10--------
    rs37597711,2
    C,F,A,H,--69867489(+) TGTTGC/G/TTGTTC 5 -- int115NS EA NA WA CSA 791
    rs783171721,2
    --69867753(+) GGAGAC/ATGGAT 5 -- int13Minor allele frequency- A:0.08CSA WA NA 240
    rs792314041,2
    C,F,--69868050(+) CCTGCC/GCAGTA 5 -- int13Minor allele frequency- G:0.07WA NA EA 358
    rs1838656131,2
    --69868092(+) AACCAC/TATTTT 5 -- int10--------

    HapMap Linkage Disequilibrium report for SLC39A9 (69864732 - 69929107 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC39A9: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC39A9 for disorders           About GeneDecksing

    1 disease for SLC39A9:    About MalaCards
    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: SLC39A9 (1 document)

    Export disorders for SLC39A9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC39A9 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with SLC39A9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium. (PubMed id 21696611)1 Chambers K.F....Lang S.H. (2011)
    4. SLC39A9 (ZIP9) regulates zinc homeostasis in the secr etory pathway: characterization of the ZIP subfamily I protein in vertebrate ce lls. (PubMed id 19420709)1 Matsuura W....Kambe T. (2009)
    5. Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571)1 Wang L....Thibodeau S.N. (2008)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55334 HGNC: 20182 AceView: SLC39A9 Ensembl:ENSG00000029364 euGenes: HUgn55334
    ECgene: SLC39A9 H-InvDB: SLC39A9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC39A9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC39A9 gene:
    Search GeneIP for patents involving SLC39A9

    GeneCards and IP:
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