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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC39A8 Gene

protein-coding   GIFtS: 55
GCID: GC04M103172

Solute Carrier Family 39 (Zinc Transporter), Member 8

(Previous names: solute carrier family 39 (metal ion transporter), member...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 81 2     ZIP82 3
Solute Carrier Family 39 (Metal Ion Transporter), Member 81 2     BCG-Induced Integral Membrane Protein In Monocyte Clone 103 Protein2 3
Solute Carrier Family 39 Member 82 3     LIV-1 Subfamily Of ZIP Zinc Transporter 62 3
BIGM1032 3     Zrt- And Irt-Like Protein 82 3
LZT-Hs62 3     BCG Induced Integral Membrane Protein BIGM1032
ZIP-82 3     Zinc Transporter ZIP82

External Ids:    HGNC: 208621   Entrez Gene: 641162   Ensembl: ENSG000001388217   OMIM: 6087325   UniProtKB: Q9C0K13   

Export aliases for SLC39A8 gene to outside databases

Previous GC identifers: GC00U913002 GC04M103641 GC04M103539 GC04M103401 GC04M098909


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC39A8 Gene:
This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of
zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and
functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary
transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding
different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this
gene have been described, but their full-length nature is not known. (provided by RefSeq, Oct 2008)

GeneCards Summary for SLC39A8 Gene: 
SLC39A8 (solute carrier family 39 (zinc transporter), member 8) is a protein-coding gene. Diseases associated with SLC39A8 include acrodermatitis, and enteropathica, and among its related super-pathways are Zinc transporters and Transmembrane transport of small molecules. GO annotations related to this gene include metal ion transmembrane transporter activity. An important paralog of this gene is SLC39A10.

UniProtKB/Swiss-Prot: S39A8_HUMAN, Q9C0K1
Function: Acts as a zinc-influx transporter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC39A8 gene promoter:
         GATA-3   GATA-2   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SLC39A8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC39A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22-q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q22-q24

SLC39A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A8 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M103172:  view genomic region     (about GC identifiers)

Start:
103,172,198 bp from pter      End:
103,352,415 bp from pter
Size:
180,218 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S39A8_HUMAN, Q9C0K1 (See protein sequence)
Recommended Name: Zinc transporter ZIP8  
Size: 460 amino acids; 49631 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Note=Associated with the
lysosomal/endosomal compartment following transfection
Secondary accessions: B4E2H3 Q96SM9 Q9BVC0 Q9NSA4
Alternative splicing: 3 isoforms:  Q9C0K1-1   Q9C0K1-2   Q9C0K1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC39A8: NX_Q9C0K1

Explore proteomics data for SLC39A8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9C0K1

  • SLC39A8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC39A8 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001128618.1  NP_001128619.1  NP_001128620.1  NP_071437.3  

    ENSEMBL proteins: 
     ENSP00000394548   ENSP00000378310   ENSP00000349174  
    Reactome Protein details: Q9C0K1
    Human Recombinant Protein Products for SLC39A8: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for SLC39A8 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0031090organelle membrane IDA12504855

    SLC39A8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 8 
    SLC39 family of metal ion transporters

    1 InterPro protein domain:
     IPR003689 ZIP

    Graphical View of Domain Structure for InterPro Entry Q9C0K1

    ProtoNet protein and cluster: Q9C0K1

    1 Blocks protein domain: IPB003689 Zinc transporter ZIP

    UniProtKB/Swiss-Prot: S39A8_HUMAN, Q9C0K1
    Similarity: Belongs to the ZIP transporter (TC 2.A.5) family


    SLC39A8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S39A8_HUMAN, Q9C0K1
    Function: Acts as a zinc-influx transporter
    Induction: By live and heat-killed Mycobacterium bovis bacterial cell wall and inflammatory cytokines like TNF.
    Down-regulated following phorbol ester treatment

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046873metal ion transmembrane transporter activity IEA--
         
    SLC39A8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC39A8:
     Decreased viability of wild-ty 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Slc39a8):
     no phenotypic analysis 

    SLC39A8 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC39A8 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC39A8 
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    SwitchGear 3'UTR luciferase reporter plasmidSLC39A8 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC39A8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Zinc transporters
    Zinc transporters0.68
    Zinc influx into cells by the SLC39 gene family0.59
    Metal ion SLC transporters0.68
    2SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6        Reactome Pathways for SLC39A8 (see all 6)
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Metal ion SLC transporters
    Zinc transporters



    SLC39A8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC39A8

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006829zinc ion transport IMP12504855
    GO:0030001metal ion transport ----
    GO:0055085transmembrane transport TAS--

    SLC39A8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC39A8 (S39A8)

    Search CenterWatch for drugs/clinical trials and news about SLC39A8 / S39A8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC39A8 gene (4 alternative transcripts): 
    NM_001135146.1  NM_001135147.1  NM_001135148.1  NM_022154.5  

    Unigene Cluster for SLC39A8:

    Solute carrier family 39 (zinc transporter), member 8
    Hs.288034  [show with all ESTs]
    Unigene Representative Sequence: NM_001135147
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000424970(uc011ceo.1) ENST00000394833(uc003hwb.1) ENST00000356736(uc003hwa.1 uc003hwc.2)
    ENST00000512337 ENST00000510255 ENST00000514000 ENST00000512657 ENST00000502903

    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC39A8 (see all 9):
    hsa-miR-4324 hsa-miR-7-2* hsa-miR-3065-5p hsa-miR-548m hsa-miR-1265 hsa-miR-544b hsa-miR-7-1* hsa-miR-532-5p
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    Additional mRNA sequence: 

    AB020969.1 AB020970.1 AB040120.1 AF193052.1 AK027652.1 AK304274.1 AL049963.2 BC001320.1 
    BC012125.1 

    12 DOTS entries:

    DT.95376295  DT.86854909  DT.100827343  DT.91759600  DT.91759599  DT.100827345  DT.100652313  DT.121273157 
    DT.99945877  DT.101971919  DT.95257636  DT.97806109 

    24/256 AceView cDNA sequences (see all 256):

    AA765231 AI536562 AI763381 AW135839 AI394743 CB158864 AI167821 AI311555 
    AI074273 AI394084 BE464953 BF064041 AA714352 BE464866 AF193052 AA788787 
    AW297138 CR624375 AI380479 AI380360 BM719513 AI492069 AI289210 AI371532 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC39A8 expression in normal human tissues (normalized intensities)      SLC39A8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCAGCAAT
    SLC39A8 Expression
    About this image


    SLC39A8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Fetal Liver CD36+ Cells   
             umbilical cord reticulocytes   
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Liver Lobule
             Human Hepatic Stellate Cells (HHSteC)   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Meninges
             Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             visceral organ/oral region/upper jaw   
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Stem Cell line 5

    See SLC39A8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC39A8

    SOURCE GeneReport for Unigene cluster: Hs.288034

    UniProtKB/Swiss-Prot: S39A8_HUMAN, Q9C0K1
    Tissue specificity: Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen,
    testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC39A8 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc39a81 , 5 solute carrier family 39 (metal ion transporter), member more1, 5 84.42(n)1
    89.35(a)1
      3 (63.04 cM)5
    675471  NM_001135149.11  NP_001128621.11 
     1358252795 
    chicken
    (Gallus gallus)
    Aves SLC39A81 solute carrier family 39 (zinc transporter), member more 72(n)
    71.69(a)
      430411  XM_427970.3  XP_427970.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC39A86
    Uncharacterized protein
    70(a)
    1 ↔ 1
    GL343323.1(35588-76357)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ036025.12   -- 77.28(n)    BJ036025.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000028931 zinc transporter ZIP8-like 61.43(n)
    59.43(a)
      100002893  XM_001342527.2  XP_001342563.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100066
    --
    18(a)
    possible ortholog
    3L(14985389-14990917)
    worm
    (Caenorhabditis elegans)
    Secernentea Y55F3BL.26
    tag-1406
    Protein TAG-140, isoform a
    25(a)
    18(a)
    many ↔ many
    many ↔ many
    IV(808674-824204)
    V(11463013-11466761)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YKE46
    Zinc transporter; localizes to the ER; null mutant...
    20(a)
    1 → many
    IX(309386-310426)


    ENSEMBL Gene Tree for SLC39A8 (if available)
    TreeFam Gene Tree for SLC39A8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC39A8 gene
    SLC39A102  SLC39A52  SLC39A62  SLC39A122  SLC39A142  SLC39A42  SLC39A72  SLC39A132  
    3 SIMAP similar genes for SLC39A8 using alignment to 1 protein entry:     S39A8_HUMAN:
    SLC39A14    SLC39A12    SLC39A4

    SLC39A8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1735 SNPs in SLC39A8 are shown (see all 1735)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6431191,2
    C,F--103171701(-) gcagtG/Caggag 1 -- ds500110Minor allele frequency- C:0.38NA WA CSA EA 370
    rs1826244761,2
    --103171717(+) GCCAGA/TGTGGC 1 -- ds50010--------
    rs2004921031,2
    --103171735(+) CACTC-/TGAG  
            
    TGAGT
    1 -- ds50010--------
    rs3707392381,2
    C--103171736(+) ACTCT-/GAGTGA
            
    GAGTG
    2 -- ds5001 cds10--------
    rs3761943391,2
    --103171738(+) TCTGA-/GTGAGT
            
    GTGAG
    2 -- ds5001 cds10--------
    rs1858182721,2
    --103171752(+) CCCGCC/TGAGCC 1 -- ds50010--------
    rs1391053021,2
    --103171768(+) CCACCA/GGGAAC 1 -- ds50010--------
    rs623278871,2
    C--103171776(+) AACTCG/AGCTGG 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs113005801,2
    C--103171782(+) GGCCC-/CGCAAG 1 -- ds50012Minor allele frequency- C:0.00NA CSA 4
    rs1824417991,2
    --103171797(+) ACCACA/GCAGAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC39A8 (103172198 - 103352415 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC39A8:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672212CNV Deletion23128226
    esv2657632CNV Deletion23128226
    esv1667320CNV Deletion17803354
    nsv428447CNV Gain18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608732    OMIM disorders: --

    8 diseases for SLC39A8:    About MalaCards
    acrodermatitis    enteropathica    acrodermatitis enteropathica    colon adenocarcinoma
    schizophrenia    adenocarcinoma    breast cancer    prostatitis


    SLC39A8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC39A8
    Human Genome Epidemiology (HuGE) Navigator: SLC39A8 (3 documents)

    Export disorders for SLC39A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC39A8 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with SLC39A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures. (PubMed id 12504855)1, 2, 3 Begum N.A....Seya T. (2002)
    2. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (2011)
    3. Genetic variants in novel pathways influence blood pre ssure and cardiovascular disease risk. (PubMed id 21909115)1, 4  ....Johnson T. (2011)
    4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (2010)
    5. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PubMed id 20864672)1, 4 Waterworth D.M....Sandhu M.S. (2010)
    6. Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (2010)
    7. Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (2008)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PubMed id 12659941)1, 3 Taylor K.M. and Nicholson R.I. (2003)
    10. ZIP8 regulates host defense through zinc-mediated inhi bition of NF-kB. (PubMed id 23403290)1 Liu M.J....Knoell D.L. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64116 HGNC: 20862 AceView: SLC39A8 Ensembl:ENSG00000138821 euGenes: HUgn64116
    ECgene: SLC39A8 H-InvDB: SLC39A8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC39A8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC39A8 gene:
    Search GeneIP for patents involving SLC39A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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