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SLC39A8 Gene

protein-coding   GIFtS: 57
GCID: GC04M103172

Solute Carrier Family 39 (Zinc Transporter), Member 8

(Previous names: solute carrier family 39 (metal ion transporter), member...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 81 2     ZIP82 3
Solute Carrier Family 39 (Metal Ion Transporter), Member 81 2     BCG-Induced Integral Membrane Protein In Monocyte Clone 103 Protein2 3
Solute Carrier Family 39 Member 82 3     LIV-1 Subfamily Of ZIP Zinc Transporter 62 3
BIGM1032 3     Zrt- And Irt-Like Protein 82 3
LZT-Hs62 3     BCG Induced Integral Membrane Protein BIGM1032
ZIP-82 3     Zinc Transporter ZIP82

External Ids:    HGNC: 208621   Entrez Gene: 641162   Ensembl: ENSG000001388217   OMIM: 6087325   UniProtKB: Q9C0K13   

Export aliases for SLC39A8 gene to outside databases

Previous GC identifers: GC00U913002 GC04M103641 GC04M103539 GC04M103401 GC04M098909


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC39A8 Gene:
This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of
zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and
functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary
transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding
different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this
gene have been described, but their full-length nature is not known. (provided by RefSeq, Oct 2008)

GeneCards Summary for SLC39A8 Gene:
SLC39A8 (solute carrier family 39 (zinc transporter), member 8) is a protein-coding gene. GO annotations related to this gene include metal ion transmembrane transporter activity. An important paralog of this gene is SLC39A10.

UniProtKB/Swiss-Prot: S39A8_HUMAN, Q9C0K1
Function: Acts as a zinc-influx transporter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC39A8 gene promoter:
         GATA-3   GATA-2   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SLC39A8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC39A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22-q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q22-q24

SLC39A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A8 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M103172:  view genomic region     (about GC identifiers)

Start:
103,172,198 bp from pter      End:
103,352,415 bp from pter
Size:
180,218 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S39A8_HUMAN, Q9C0K1 (See protein sequence)
Recommended Name: Zinc transporter ZIP8  
Size: 460 amino acids; 49631 Da
Secondary accessions: B4E2H3 Q96SM9 Q9BVC0 Q9NSA4
Alternative splicing: 3 isoforms:  Q9C0K1-1   Q9C0K1-2   Q9C0K1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC39A8: NX_Q9C0K1

Explore proteomics data for SLC39A8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn273
  • Modification sites at PhosphoSitePlus

  • See SLC39A8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001128618.1  NP_001128619.1  NP_001128620.1  NP_071437.3  

    ENSEMBL proteins: 
     ENSP00000394548   ENSP00000378310   ENSP00000349174  
    Reactome Protein details: Q9C0K1

    SLC39A8 Human Recombinant Protein Products:

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    Novus Biologicals SLC39A8 Proteins
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    Cloud-Clone Corp. Proteins for SLC39A8

     
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    antibodies-online proteins for SLC39A8 (4 products) 

     
    antibodies-online peptides for SLC39A8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 8
    SLC39 family of metal ion transporters

    1 InterPro protein domain:
     IPR003689 ZIP

    Graphical View of Domain Structure for InterPro Entry Q9C0K1

    ProtoNet protein and cluster: Q9C0K1

    1 Blocks protein domain: IPB003689 Zinc transporter ZIP

    UniProtKB/Swiss-Prot: S39A8_HUMAN, Q9C0K1
    Similarity: Belongs to the ZIP transporter (TC 2.A.5) family


    Find genes that share domains with SLC39A8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S39A8_HUMAN, Q9C0K1
    Function: Acts as a zinc-influx transporter
    Induction: By live and heat-killed Mycobacterium bovis bacterial cell wall and inflammatory cytokines like TNF.
    Down-regulated following phorbol ester treatment

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046873metal ion transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC39A8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC39A8:
     Decreased viability of wild-ty 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Slc39a8):
     no phenotypic analysis 

    Find genes that share phenotypes with SLC39A8           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC39A8

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC39A8:
    hsa-mir-331-3p (MIRT043292), hsa-mir-30c-1-3p (MIRT038538), hsa-mir-192-5p (MIRT026917), hsa-mir-1260b (MIRT052741), hsa-mir-215-5p (MIRT024337)

    Block miRNA regulation of human, mouse, rat SLC39A8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC39A8 (see all 9):
    hsa-miR-4324 hsa-miR-7-2* hsa-miR-3065-5p hsa-miR-548m hsa-miR-1265 hsa-miR-544b hsa-miR-7-1* hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC39A8 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S39A8_HUMAN, Q9C0K1: Membrane; Multi-pass membrane protein (Potential). Note=Associated with the
    lysosomal/endosomal compartment following transfection
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    endosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0031090organelle membrane IDA12504855

    Find genes that share ontologies with SLC39A8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC39A8 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    2Metal ion SLC transporters
    Metal ion SLC transporters
    Zinc influx into cells by the SLC39 gene family0.00
    Zinc transporters0.00


    Find genes that share SuperPaths with SLC39A8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC39A8
        Zinc influx into cells by the SLC39 gene family


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC39A8
    Interactions:

        Search GeneGlobe Interaction Network for SLC39A8

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SLC39A8 (ENSP000003491744) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC30A5ENSP000003798364STRING: ENSP00000379836
    SLC30A6ENSP000002825874STRING: ENSP00000282587
    SLC30A7ENSP000003502784STRING: ENSP00000350278
    SLC30A1ENSP000003559684STRING: ENSP00000355968
    SLC30A10ENSP000003558934STRING: ENSP00000355893
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006829zinc ion transport IMP12504855
    GO:0030001metal ion transport ----
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLC39A8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC39A8 (S39A8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC39A8 gene (4 alternative transcripts): 
    NM_001135146.1  NM_001135147.1  NM_001135148.1  NM_022154.5  

    Unigene Cluster for SLC39A8:

    Solute carrier family 39 (zinc transporter), member 8
    Hs.288034  [show with all ESTs]
    Unigene Representative Sequence: NM_001135147
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000424970(uc011ceo.1) ENST00000394833(uc003hwb.1) ENST00000356736(uc003hwa.1 uc003hwc.2)
    ENST00000512337 ENST00000510255 ENST00000514000 ENST00000512657 ENST00000502903

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC39A8 (see all 9):
    hsa-miR-4324 hsa-miR-7-2* hsa-miR-3065-5p hsa-miR-548m hsa-miR-1265 hsa-miR-544b hsa-miR-7-1* hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC39A8 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC39A8
      QuantiFast Probe-based Assays in human, mouse, rat SLC39A8

    Additional mRNA sequence: 

    AB020969.1 AB020970.1 AB040120.1 AF193052.1 AK027652.1 AK304274.1 AL049963.2 BC001320.1 
    BC012125.1 

    12 DOTS entries:

    DT.95376295  DT.86854909  DT.100827343  DT.91759600  DT.91759599  DT.100827345  DT.100652313  DT.121273157 
    DT.99945877  DT.101971919  DT.95257636  DT.97806109 

    Selected AceView cDNA sequences (see all 256):

    BF000582 AI769630 C01870 AA913595 CB132773 AI391467 AA213557 AI392864 
    AI738652 AI206052 AA765231 AI536562 AI763381 AW135839 AI394743 CB158864 
    AI167821 AI311555 AI074273 AI394084 BE464953 BF064041 AA714352 BE464866 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC39A8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCAGCAAT
    SLC39A8 Expression
    About this image


    SLC39A8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Meninges
             Midbrain dopaminergic-like neurons
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Bulge Stem Cells Bulge
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Stem Cell line 5
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
    SLC39A8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC39A8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.288034

    UniProtKB/Swiss-Prot: S39A8_HUMAN, Q9C0K1
    Tissue specificity: Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen,
    testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC39A8 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc39a81 , 5 solute carrier family 39 (metal ion transporter), member more1, 5 84.42(n)1
    89.35(a)1
      3 (63.04 cM)5
    675471  NM_001135149.11  NP_001128621.11 
     1358252795 
    chicken
    (Gallus gallus)
    Aves SLC39A81 solute carrier family 39 (zinc transporter), member more 72.25(n)
    72.09(a)
      430411  XM_427970.4  XP_427970.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC39A86
    solute carrier family 39 (zinc transporter), membe...
    72(a)
    1 ↔ 1
    GL343323.1(35588-76357)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ036025.12   -- 77.28(n)    BJ036025.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000028931 zinc transporter ZIP8-like 58.04(n)
    54.39(a)
      100002893  XM_001342527.3  XP_001342563.3 
    worm
    (Caenorhabditis elegans)
    Secernentea Y55F3BL.26
    tag-1406
    --
    Protein TAG-140, isoform a (tag-140) mRNA, complet...
    31(a)
    18(a)
    many ↔ many
    many ↔ many
    IV(807439-824941) WBGene00021936
    V(11463013-11466761) WBGene00006486
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YKE46
    Zinc transporter; localizes to the ER; null mutant...
    21(a)
    1 → many
    IX(309386-310426) YIL023C


    ENSEMBL Gene Tree for SLC39A8 (if available)
    TreeFam Gene Tree for SLC39A8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC39A8 gene
    SLC39A102  SLC39A52  SLC39A62  SLC39A122  SLC39A42  SLC39A142  SLC39A132  SLC39A72  
    3 SIMAP similar genes for SLC39A8 using alignment to 1 protein entry:     S39A8_HUMAN:
    SLC39A14    SLC39A12    SLC39A4

    Find genes that share paralogs with SLC39A8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC39A8 (see all 1735)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6431191,2
    C,F--103171701(-) gcagtG/Caggag 1 -- ds500110Minor allele frequency- C:0.38NA WA CSA EA 370
    rs1826244761,2
    --103171717(+) GCCAGA/TGTGGC 1 -- ds50010--------
    rs2004921031,2
    --103171735(+) CACTC-/TGAG  
            
    TGAGT
    1 -- ds50010--------
    rs3707392381,2
    C--103171736(+) ACTCT-/GAGTGA
            
    GAGTG
    2 -- ds5001 cds10--------
    rs3761943391,2
    --103171738(+) TCTGA-/GTGAGT
            
    GTGAG
    2 -- ds5001 cds10--------
    rs1858182721,2
    --103171752(+) CCCGCC/TGAGCC 1 -- ds50010--------
    rs1391053021,2
    --103171768(+) CCACCA/GGGAAC 1 -- ds50010--------
    rs623278871,2
    C--103171776(+) AACTCG/AGCTGG 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs113005801,2
    C--103171782(+) GGCCC-/CGCAAG 1 -- ds50012Minor allele frequency- C:0.00NA CSA 4
    rs1824417991,2
    --103171797(+) ACCACA/GCAGAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC39A8 (103172198 - 103352415 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC39A8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672212CNV Deletion23128226
    esv2657632CNV Deletion23128226
    esv1667320CNV Deletion17803354
    nsv428447CNV Gain18775914

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608732    OMIM disorders: --


    Find genes that share disorders with SLC39A8           About GenesLikeMe

    Genetic Association Database (GAD): SLC39A8
    Human Genome Epidemiology (HuGE) Navigator: SLC39A8 (3 documents)

    Export disorders for SLC39A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC39A8 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with SLC39A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures. (PubMed id 12504855)1, 2, 3 Begum N.A....Seya T. (Genomics 2002)
    2. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (Nat. Genet. 2011)
    3. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PubMed id 21909115)1, 4  ....Johnson T. (Nature 2011)
    4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (Nat. Genet. 2010)
    5. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PubMed id 20864672)1, 4 Waterworth D.M....Sandhu M.S. (Arterioscler. Thromb. Vasc. Biol. 2010)
    6. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    7. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PubMed id 12659941)1, 3 Taylor K.M. and Nicholson R.I. (Biochim. Biophys. Acta 2003)
    10. ZIP8 regulates host defense through zinc-mediated inhibition of NF-I_B. (PubMed id 23403290)1 Liu M.J....Knoell D.L. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64116 HGNC: 20862 AceView: SLC39A8 Ensembl:ENSG00000138821 euGenes: HUgn64116
    ECgene: SLC39A8 H-InvDB: SLC39A8

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC39A8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC39A8 gene:
    Search GeneIP for patents involving SLC39A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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