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Aliases for SLC39A8 Gene

Aliases for SLC39A8 Gene

  • Solute Carrier Family 39 Member 8 2 3 4
  • Solute Carrier Family 39 (Zinc Transporter), Member 8 2 3 5
  • BCG-Induced Integral Membrane Protein In Monocyte Clone 103 Protein 3 4
  • Solute Carrier Family 39 (Metal Ion Transporter), Member 8 2 3
  • LIV-1 Subfamily Of ZIP Zinc Transporter 6 3 4
  • Zrt- And Irt-Like Protein 8 3 4
  • BIGM103 3 4
  • LZT-Hs6 3 4
  • ZIP-8 3 4
  • ZIP8 3 4
  • BCG Induced Integral Membrane Protein BIGM103 3
  • PP3105 3
  • CDG2N 3

External Ids for SLC39A8 Gene

Previous GeneCards Identifiers for SLC39A8 Gene

  • GC00U913002
  • GC04M103641
  • GC04M103539
  • GC04M103401
  • GC04M103172
  • GC04M098909

Summaries for SLC39A8 Gene

Entrez Gene Summary for SLC39A8 Gene

  • This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]

GeneCards Summary for SLC39A8 Gene

SLC39A8 (Solute Carrier Family 39 Member 8) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. GO annotations related to this gene include metal ion transmembrane transporter activity. An important paralog of this gene is SLC39A12.

UniProtKB/Swiss-Prot for SLC39A8 Gene

  • Acts as a zinc-influx transporter.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A8 Gene

Genomics for SLC39A8 Gene

Regulatory Elements for SLC39A8 Gene

Promoters for SLC39A8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC39A8 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SLC39A8 gene promoter:

Genomic Location for SLC39A8 Gene

Chromosome:
4
Start:
102,251,041 bp from pter
End:
102,431,258 bp from pter
Size:
180,218 bases
Orientation:
Minus strand

Genomic View for SLC39A8 Gene

Genes around SLC39A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A8 Gene

Proteins for SLC39A8 Gene

  • Protein details for SLC39A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0K1-S39A8_HUMAN
    Recommended name:
    Zinc transporter ZIP8
    Protein Accession:
    Q9C0K1
    Secondary Accessions:
    • B4E2H3
    • Q96SM9
    • Q9BVC0
    • Q9NSA4

    Protein attributes for SLC39A8 Gene

    Size:
    460 amino acids
    Molecular mass:
    49631 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC39A8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A8 Gene

Proteomics data for SLC39A8 Gene at MOPED

Post-translational modifications for SLC39A8 Gene

  • Glycosylation at Asn 273
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC39A8 Gene

Antibody Products

No data available for DME Specific Peptides for SLC39A8 Gene

Domains & Families for SLC39A8 Gene

Gene Families for SLC39A8 Gene

Protein Domains for SLC39A8 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9C0K1

UniProtKB/Swiss-Prot:

S39A8_HUMAN :
  • Belongs to the ZIP transporter (TC 2.A.5) family.
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A8: view

Function for SLC39A8 Gene

Molecular function for SLC39A8 Gene

UniProtKB/Swiss-Prot Function:
Acts as a zinc-influx transporter.
UniProtKB/Swiss-Prot Induction:
By live and heat-killed Mycobacterium bovis bacterial cell wall and inflammatory cytokines like TNF. Down-regulated following phorbol ester treatment.
genes like me logo Genes that share phenotypes with SLC39A8: view

Animal Models for SLC39A8 Gene

MGI Knock Outs for SLC39A8:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC39A8 Gene

Localization for SLC39A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A8 Gene

Membrane; Multi-pass membrane protein. Note=Associated with the lysosomal/endosomal compartment following transfection. {ECO:0000269 PubMed:12504855}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC39A8 Gene COMPARTMENTS Subcellular localization image for SLC39A8 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC39A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IDA 12504855
genes like me logo Genes that share ontologies with SLC39A8: view

Pathways & Interactions for SLC39A8 Gene

genes like me logo Genes that share pathways with SLC39A8: view

Interacting Proteins for SLC39A8 Gene

Gene Ontology (GO) - Biological Process for SLC39A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
GO:0070574 cadmium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC39A8: view

No data available for SIGNOR curated interactions for SLC39A8 Gene

Drugs & Compounds for SLC39A8 Gene

No Compound Related Data Available

Transcripts for SLC39A8 Gene

Unigene Clusters for SLC39A8 Gene

Solute carrier family 39 (zinc transporter), member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A8 Gene

No ASD Table

Relevant External Links for SLC39A8 Gene

GeneLoc Exon Structure for
SLC39A8
ECgene alternative splicing isoforms for
SLC39A8

Expression for SLC39A8 Gene

mRNA expression in normal human tissues for SLC39A8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC39A8 Gene

This gene is overexpressed in Lung (x8.4).

Protein differential expression in normal tissues from HIPED for SLC39A8 Gene

This gene is overexpressed in Placenta (27.6), Milk (21.7), and Bone (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC39A8 Gene



SOURCE GeneReport for Unigene cluster for SLC39A8 Gene Hs.288034

mRNA Expression by UniProt/SwissProt for SLC39A8 Gene

Q9C0K1-S39A8_HUMAN
Tissue specificity: Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.
genes like me logo Genes that share expression patterns with SLC39A8: view

Protein tissue co-expression partners for SLC39A8 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC39A8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC39A8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC39A8 35
  • 90.58 (n)
  • 92.39 (a)
SLC39A8 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC39A8 35
  • 91.09 (n)
  • 91.52 (a)
SLC39A8 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc39a8 35
  • 84.42 (n)
  • 89.35 (a)
Slc39a8 16
Slc39a8 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC39A8 35
  • 99.71 (n)
  • 100 (a)
SLC39A8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc39a8 35
  • 84.2 (n)
  • 88.04 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC39A8 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC39A8 35
  • 72.25 (n)
  • 72.09 (a)
SLC39A8 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC39A8 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a8 35
  • 65.04 (n)
  • 62.56 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100002893 35
  • 58.04 (n)
  • 54.39 (a)
SLC39A8 (1 of 2) 36
  • 54 (a)
OneToMany
SLC39A8 (2 of 2) 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-140 36
  • 18 (a)
ManyToMany
Y55F3BL.2 36
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKE4 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for SLC39A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A8 Gene

ENSEMBL:
Gene Tree for SLC39A8 (if available)
TreeFam:
Gene Tree for SLC39A8 (if available)

Paralogs for SLC39A8 Gene

(3) SIMAP similar genes for SLC39A8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC39A8: view

Variants for SLC39A8 Gene

Sequence variations from dbSNP and Humsavar for SLC39A8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs13107325 - 102,267,552(+) TGGAG(A/C/T)GAAAT reference, missense
rs233804 -- 102,291,759(+) TGACA(A/C)CAGGA intron-variant
rs233805 -- 102,291,707(+) GGGAT(G/T)GCCTA intron-variant
rs233806 -- 102,291,689(+) TGTTA(C/T)GCCCC intron-variant
rs233807 -- 102,291,355(+) ACGTC(C/T)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A8 Gene

Variant ID Type Subtype PubMed ID
nsv428447 CNV Gain 18775914
esv2672212 CNV Deletion 23128226
esv2657632 CNV Deletion 23128226
esv1667320 CNV Deletion 17803354

Variation tolerance for SLC39A8 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC39A8 Gene

HapMap Linkage Disequilibrium report
SLC39A8
Human Gene Mutation Database (HGMD)
SLC39A8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A8 Gene

Disorders for SLC39A8 Gene

Relevant External Links for SLC39A8

Genetic Association Database (GAD)
SLC39A8
Human Genome Epidemiology (HuGE) Navigator
SLC39A8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC39A8

No disorders were found for SLC39A8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A8 Gene

Publications for SLC39A8 Gene

  1. Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures. (PMID: 12504855) Begum N.A. … Seya T. (Genomics 2002) 2 3 4 67
  2. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PMID: 12659941) Taylor K.M. … Nicholson R.I. (Biochim. Biophys. Acta 2003) 2 3
  3. Cadmium concentrations in human blood and urine are associated with polymorphisms in zinc transporter genes. (PMID: 24514587) Rentschler G. … Broberg K. (Metallomics 2014) 3
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  5. ZIP8 regulates host defense through zinc-mediated inhibition of NF-I_B. (PMID: 23403290) Liu M.J. … Knoell D.L. (Cell Rep 2013) 3

Products for SLC39A8 Gene

Sources for SLC39A8 Gene

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