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Aliases for SLC39A8 Gene

Aliases for SLC39A8 Gene

  • Solute Carrier Family 39 (Zinc Transporter), Member 8 2 3
  • BCG-Induced Integral Membrane Protein In Monocyte Clone 103 Protein 3 4
  • Solute Carrier Family 39 (Metal Ion Transporter), Member 8 2 3
  • LIV-1 Subfamily Of ZIP Zinc Transporter 6 3 4
  • Solute Carrier Family 39 Member 8 3 4
  • Zrt- And Irt-Like Protein 8 3 4
  • BIGM103 3 4
  • LZT-Hs6 3 4
  • ZIP-8 3 4
  • ZIP8 3 4
  • BCG Induced Integral Membrane Protein BIGM103 3
  • Zinc Transporter ZIP8 3
  • PP3105 3

External Ids for SLC39A8 Gene

Summaries for SLC39A8 Gene

Entrez Gene Summary for SLC39A8 Gene

  • This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]

GeneCards Summary for SLC39A8 Gene

SLC39A8 (Solute Carrier Family 39 (Zinc Transporter), Member 8) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include metal ion transmembrane transporter activity. An important paralog of this gene is SLC39A12.

UniProtKB/Swiss-Prot for SLC39A8 Gene

  • Acts as a zinc-influx transporter.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A8 Gene

Genomics for SLC39A8 Gene

Genomic Location for SLC39A8 Gene

Start:
102,251,041 bp from pter
End:
102,431,258 bp from pter
Size:
180,218 bases
Orientation:
Minus strand

Genomic View for SLC39A8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC39A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A8 Gene

Regulatory Elements for SLC39A8 Gene

Transcription factor binding sites by QIAGEN in the SLC39A8 gene promoter:

Proteins for SLC39A8 Gene

  • Protein details for SLC39A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0K1-S39A8_HUMAN
    Recommended name:
    Zinc transporter ZIP8
    Protein Accession:
    Q9C0K1
    Secondary Accessions:
    • B4E2H3
    • Q96SM9
    • Q9BVC0
    • Q9NSA4

    Protein attributes for SLC39A8 Gene

    Size:
    460 amino acids
    Molecular mass:
    49631 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC39A8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A8 Gene

Proteomics data for SLC39A8 Gene at MOPED

Post-translational modifications for SLC39A8 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn273

Other Protein References for SLC39A8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC39A8 Gene

Domains for SLC39A8 Gene

Gene Families for SLC39A8 Gene

Protein Domains for SLC39A8 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

S39A8_HUMAN
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.:
    • Q9C0K1
genes like me logo Genes that share domains with SLC39A8: view

Function for SLC39A8 Gene

Molecular function for SLC39A8 Gene

UniProtKB/Swiss-Prot Function: Acts as a zinc-influx transporter.
UniProtKB/Swiss-Prot Induction: By live and heat-killed Mycobacterium bovis bacterial cell wall and inflammatory cytokines like TNF. Down-regulated following phorbol ester treatment.

Gene Ontology (GO) - Molecular Function for SLC39A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A8: view

Phenotypes for SLC39A8 Gene

MGI mutant phenotypes for SLC39A8:
inferred from 2 alleles
GenomeRNAi human phenotypes for SLC39A8:
genes like me logo Genes that share phenotypes with SLC39A8: view

miRNA for SLC39A8 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC39A8 Gene

Localization for SLC39A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A8 Gene

Membrane; Multi-pass membrane protein. Note=Associated with the lysosomal/endosomal compartment following transfection. {ECO:0000269 PubMed:12504855}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC39A8 Gene COMPARTMENTS Subcellular localization image for SLC39A8 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for SLC39A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IDA 12504855
genes like me logo Genes that share ontologies with SLC39A8: view

Pathways for SLC39A8 Gene

genes like me logo Genes that share pathways with SLC39A8: view

Interacting Proteins for SLC39A8 Gene

Gene Ontology (GO) - Biological Process for SLC39A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006829 zinc II ion transport IMP 12504855
GO:0030001 metal ion transport --
GO:0055085 transmembrane transport TAS --
GO:0070574 cadmium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC39A8: view

Transcripts for SLC39A8 Gene

Unigene Clusters for SLC39A8 Gene

Solute carrier family 39 (zinc transporter), member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A8 Gene

No ASD Table

Relevant External Links for SLC39A8 Gene

GeneLoc Exon Structure for
SLC39A8
ECgene alternative splicing isoforms for
SLC39A8

Expression for SLC39A8 Gene

mRNA expression in normal human tissues for SLC39A8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC39A8 Gene

This gene is overexpressed in Lung (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC39A8 Gene

SOURCE GeneReport for Unigene cluster for SLC39A8 Gene Hs.288034

mRNA Expression by UniProt/SwissProt for SLC39A8 Gene

Q9C0K1-S39A8_HUMAN
Tissue specificity: Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.
genes like me logo Genes that share expressions with SLC39A8: view

Orthologs for SLC39A8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC39A8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC39A8 36
  • 99.71 (n)
  • 100 (a)
SLC39A8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC39A8 36
  • 90.58 (n)
  • 92.39 (a)
SLC39A8 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC39A8 36
  • 91.09 (n)
  • 91.52 (a)
SLC39A8 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc39a8 36
  • 84.42 (n)
  • 89.35 (a)
Slc39a8 16
Slc39a8 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC39A8 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 57 (a)
OneToMany
-- 37
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc39a8 36
  • 84.2 (n)
  • 88.04 (a)
chicken
(Gallus gallus)
Aves SLC39A8 36
  • 72.25 (n)
  • 72.09 (a)
SLC39A8 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC39A8 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a8 36
  • 65.04 (n)
  • 62.56 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100002893 36
  • 58.04 (n)
  • 54.39 (a)
SLC39A8 (1 of 2) 37
  • 54 (a)
OneToMany
SLC39A8 (2 of 2) 37
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-140 37
  • 18 (a)
ManyToMany
Y55F3BL.2 37
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKE4 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToMany
Species with no ortholog for SLC39A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A8 Gene

ENSEMBL:
Gene Tree for SLC39A8 (if available)
TreeFam:
Gene Tree for SLC39A8 (if available)

Paralogs for SLC39A8 Gene

Selected SIMAP similar genes for SLC39A8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC39A8: view

Variants for SLC39A8 Gene

Sequence variations from dbSNP and Humsavar for SLC39A8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs9331 -- 102,262,061(+) CTCTC(A/G)ATCAC utr-variant-3-prime, intron-variant
rs9705 -- 102,262,374(-) TAAGT(A/G)TAAAC utr-variant-3-prime, intron-variant
rs63519 -- 102,281,757(-) GTACA(G/T)AGTAG intron-variant
rs149268 -- 102,254,135(-) TCACA(A/G)AGGAG intron-variant
rs151368 -- 102,259,956(-) ATCTA(A/T)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A8 Gene

Variant ID Type Subtype PubMed ID
nsv428447 CNV Gain 18775914
esv2672212 CNV Deletion 23128226
esv2657632 CNV Deletion 23128226
esv1667320 CNV Deletion 17803354

Relevant External Links for SLC39A8 Gene

HapMap Linkage Disequilibrium report
SLC39A8
Human Gene Mutation Database (HGMD)
SLC39A8

Disorders for SLC39A8 Gene

Relevant External Links for SLC39A8

Genetic Association Database (GAD)
SLC39A8
Human Genome Epidemiology (HuGE) Navigator
SLC39A8
genes like me logo Genes that share disorders with SLC39A8: view

No data available for UniProtKB/Swiss-Prot for SLC39A8 Gene

Publications for SLC39A8 Gene

  1. Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures. (PMID: 12504855) Begum N.A. … Seya T. (Genomics 2002) 2 3 4
  2. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PMID: 12659941) Taylor K.M. … Nicholson R.I. (Biochim. Biophys. Acta 2003) 2 3
  3. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 49
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 49

Products for SLC39A8 Gene

Sources for SLC39A8 Gene

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