Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC39A7 Gene

protein-coding   GIFtS: 58
GCID: GC06P033168

Solute Carrier Family 39 (Zinc Transporter), Member 7

(Previous name: HLA class II region expressed gene KE4)
(Previous symbol: HKE4)
  Search for SLC39A7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 71 2     ZIP72 3
HKE41 2 3 5     D6S2244E2 5
HLA Class II Region Expressed Gene KE41 2     D6S115E2
Histidine-Rich Membrane Protein Ke42 3     H2-KE42
Really Interesting New Gene 5 Protein2 3     KE42
Solute Carrier Family 39 Member 72 3     Ke4 Gene, Mouse, Human Homolog Of2
Zrt-, Irt-Like Protein 72 3     Zinc Transporter SLC39A72
RING52 3     

External Ids:    HGNC: 49271   Entrez Gene: 79222   Ensembl: ENSG000001124737   OMIM: 6014165   UniProtKB: Q925043   

Export aliases for SLC39A7 gene to outside databases

Previous GC identifers: GC06P033215 GC06P033276 GC06P032910


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC39A7 Gene:
The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This
transport may be important for activation of tyrosine kinases, some of which could be involved in cancer
progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jan 2014)

GeneCards Summary for SLC39A7 Gene:
SLC39A7 (solute carrier family 39 (zinc transporter), member 7) is a protein-coding gene. GO annotations related to this gene include metal ion transmembrane transporter activity. An important paralog of this gene is SLC39A10.

UniProtKB/Swiss-Prot: S39A7_HUMAN, Q92504
Function: Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol.
Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+)

Gene Wiki entry for SLC39A7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC39A7 gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC39A7 promoter sequence
   Search Chromatin IP Primers for SLC39A7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC39A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

SLC39A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P033168:  view genomic region     (about GC identifiers)

Start:
33,168,222 bp from pter      End:
33,172,216 bp from pter
Size:
3,995 bases      Orientation:
plus strand

5 alternative locations:
Chr6+,NT_167247 4,642,364-4,645,975      Chr6+,NT_113891.2 4,612,437-4,616,048      Chr6+,NT_167245 4,449,910-4,453,521     
Chr6+,NT_167246 4,625,919-4,629,530      Chr6+,NT_167248 4,400,826-4,404,437     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: S39A7_HUMAN, Q92504 (See protein sequence)
Recommended Name: Zinc transporter SLC39A7  
Size: 469 amino acids; 50118 Da
Secondary accessions: B0UXF6 Q5STP8 Q9UIQ0

Explore the universe of human proteins at neXtProt for SLC39A7: NX_Q92504

Explore proteomics data for SLC39A7 at MOPED

Post-translational modifications: 

  • Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic
    Zn(2+) release1
  • Ubiquitination2 at Lys310
  • Modification sites at PhosphoSitePlus

  • See SLC39A7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001070984.1  NP_001275706.1  NP_008910.2  

    ENSEMBL proteins: 
     ENSP00000400978   ENSP00000363807   ENSP00000363809  
    Reactome Protein details: Q92504

    SLC39A7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SLC39A7
    OriGene Protein Over-expression Lysate for SLC39A7
    OriGene MassSpec for SLC39A7
    OriGene Custom Protein Services for SLC39A7
    GenScript Custom Purified and Recombinant Proteins Services for SLC39A7
    Novus Biologicals SLC39A7 Proteins
    Novus Biologicals SLC39A7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC39A7

     
    Search eBioscience for Proteins for SLC39A7 

    SLC39A7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SLC39A7
    OriGene Custom Antibody Services for SLC39A7
    Novus Biologicals SLC39A7 Antibodies
    Abcam antibodies for SLC39A7
    Cloud-Clone Corp. Antibodies for SLC39A7
    ThermoFisher Antibodies for SLC39A7
    LSBio Antibodies in human, mouse, rat for SLC39A7

    SLC39A7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC39A7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC39A7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLC39A7
    Cloud-Clone Corp. CLIAs for SLC39A7
    Search eBioscience for ELISAs for SLC39A7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 7
    SLC39 family of metal ion transporters

    1 InterPro protein domain:
     IPR003689 ZIP

    Graphical View of Domain Structure for InterPro Entry Q92504

    ProtoNet protein and cluster: Q92504

    1 Blocks protein domain: IPB003689 Zinc transporter ZIP

    UniProtKB/Swiss-Prot: S39A7_HUMAN, Q92504
    Similarity: Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily


    Find genes that share domains with SLC39A7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S39A7_HUMAN, Q92504
    Function: Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol.
    Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+)
    Induction: Down-regulated by Zn(+2)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0046873metal ion transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC39A7           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Slc39a7 (no phenotypes)

    Find genes that share phenotypes with SLC39A7           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC39A7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC39A7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC39A7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC39A7

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC39A7:
    hsa-mir-1229-3p (MIRT036341), hsa-mir-128-3p (MIRT022098), hsa-mir-340-5p (MIRT019558)

    Block miRNA regulation of human, mouse, rat SLC39A7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC39A7 (see all 9):
    hsa-miR-3163 hsa-miR-642a hsa-miR-670 hsa-miR-3180-3p hsa-miR-34b hsa-miR-3176 hsa-miR-548c-3p hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidSLC39A7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC39A7
    Predesigned siRNA for gene silencing in human, mouse, rat SLC39A7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC39A7

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC39A7 (see all 13)
    OriGene ORF clones in mouse, rat for SLC39A7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC39A7 (NM_006979)
    Sino Biological Human cDNA Clone for SLC39A7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC39A7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC39A7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC39A7
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC39A7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    S39A7_HUMAN, Q92504: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi
    network membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane3
    cytosol1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005794Golgi apparatus IEA--
    GO:0016020membrane TAS8812499
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC39A7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC39A7 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    2Metal ion SLC transporters
    Metal ion SLC transporters
    Zinc influx into cells by the SLC39 gene family0.00
    Zinc transporters0.00


    Find genes that share SuperPaths with SLC39A7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SLC39A7
        Zinc influx into cells by the SLC39 gene family


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC39A7
    Interactions:

        Search GeneGlobe Interaction Network for SLC39A7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SLC39A7 (Q925041, 3 ENSP000003638074) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RGS20O760813, ENSP000002973134I2D: score=2 STRING: ENSP00000297313
    USP49Q70CQ13, ENSP000002972294I2D: score=2 STRING: ENSP00000297229
    CD40P259423, ENSP000003613594I2D: score=2 STRING: ENSP00000361359
    DCLK1O150753I2D: score=5 
    ITGB2P051073I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006829zinc ion transport IEA--
    GO:0030001metal ion transport ----
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLC39A7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC39A7 (S39A7)

    2 Novoseek inferred chemical compound relationships for SLC39A7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 40 35 15705588 (8), 18583420 (4), 14525538 (2)
    steroid 23.5 1 9205114 (1)



    Find genes that share compounds with SLC39A7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC39A7 gene (3 alternative transcripts): 
    NM_001077516.1  NM_001288777.1  NM_006979.2  

    Unigene Cluster for SLC39A7:

    Solute carrier family 39 (zinc transporter), member 7
    Hs.631995  [show with all ESTs]
    Unigene Representative Sequence: NM_006979
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444757 ENST00000374675(uc003odf.3 uc011dqv.2) ENST00000374677(uc003odg.3)
    ENST00000463972
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC39A7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC39A7 (see all 9):
    hsa-miR-3163 hsa-miR-642a hsa-miR-670 hsa-miR-3180-3p hsa-miR-34b hsa-miR-3176 hsa-miR-548c-3p hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidSLC39A7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC39A7
    Predesigned siRNA for gene silencing in human, mouse, rat SLC39A7
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC39A7 (see all 13)
    OriGene ORF clones in mouse, rat for SLC39A7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC39A7 (NM_006979)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC39A7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC39A7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC39A7
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC39A7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC39A7
      QuantiTect SYBR Green Assays in human, mouse, rat SLC39A7
      QuantiFast Probe-based Assays in human, mouse, rat SLC39A7

    Additional mRNA sequence: 

    AK225282.1 AK225682.1 AK301126.1 AK303158.1 BC000645.2 D82060.1 M58660.1 

    15 DOTS entries:

    DT.100811035  DT.86852803  DT.211216  DT.121347033  DT.118619  DT.100811029  DT.100811027  DT.100811028 
    DT.102840516  DT.121347066  DT.92443820  DT.100706837  DT.121347038  DT.121347042  DT.92443822 

    Selected AceView cDNA sequences (see all 365):

    BQ958318 BU687925 BE275203 AA319058 BU541988 BM717786 BG287940 CB135931 
    BM452498 F31664 BF991560 AL555459 AA854721 BF971233 CR592348 BM831059 
    BP359168 AI888354 AW134912 NM_014234 BP341645 BI763892 BC000645 AA918575 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A7    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:              -                                                         
    SP2:                                                                        
    SP3:              -     -                                                   


    ECgene alternative splicing isoforms for SLC39A7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC39A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGATTTT
    SLC39A7 Expression
    About this image


    SLC39A7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Neural Crest (Gastrulation Derivatives)
             Cranial Neural Crest Cells Branchial Arch 1
     
     Head Mesenchyme (Muscoskeletal System)
             Cranial Neural Crest Cells Branchial Arch 1
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
    SLC39A7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC39A7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631995

    UniProtKB/Swiss-Prot: S39A7_HUMAN, Q92504
    Tissue specificity: Widely expressed

        Custom PCR Arrays for SLC39A7
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC39A7
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC39A7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC39A7
    QuantiTect SYBR Green Assays in human, mouse, rat SLC39A7
    QuantiFast Probe-based Assays in human, mouse, rat SLC39A7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC39A7 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc39a71 , 5 solute carrier family 39 (zinc transporter), member more1, 5 84.05(n)1
    85.26(a)1
      17 (17.98 cM)5
    149771  NM_008202.21  NP_032228.21 
     340282695 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    32(a)
    many ↔ many
    GL343636.1(1418-3338)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.193422 Xenopus laevis transcribed sequence with weak similarity more 76.67(n)    BX854086.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ke42 ke4 76.25(n)   30094  AY314993.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Catsup6
    Catecholamines up
    50(a)
    1 ↔ 1
    2L(19041714-19043614)
    worm
    (Caenorhabditis elegans)
    Secernentea hke-4.21 hke-4.2 56.81(n)
    55.79(a)
      181640  NM_078162.4  NP_510563.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YKE4(YIL023C)4
    YKE41
    Zinc transporter; localizes to the ER; null mutant more4
    YKE41
    44.4(n)1
    36.82(a)1
      9(310426-309386)4
    8547891, 4  NP_012241.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IAR11 IAR1 47.23(n)
    43(a)
      843138  NM_105480.2  NP_564921.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g04674001 Os08g0467400 50.53(n)
    44.27(a)
      4345792  NM_001068538.1  NP_001062003.1 


    ENSEMBL Gene Tree for SLC39A7 (if available)
    TreeFam Gene Tree for SLC39A7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC39A7 gene
    SLC39A102  SLC39A52  SLC39A82  SLC39A62  SLC39A122  SLC39A42  SLC39A142  SLC39A132  

    Find genes that share paralogs with SLC39A7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    3 SNPs for SLC39A7    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10487781,2,4
    ----see VAR_0500362 mis40--------
    rs356907121,2,4
    ----see VAR_0500352 mis40--------
    rs342111881,2,4
    ----see VAR_0500342 mis40--------

    HapMap Linkage Disequilibrium report for SLC39A7 (33168222 - 33172216 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC39A7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv885768CNV Loss21882294
    nsv830634CNV Loss17160897
    nsv522719CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC39A7
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC39A7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601416    OMIM disorders: --


    Find genes that share disorders with SLC39A7           About GenesLikeMe

    Genetic Association Database (GAD): SLC39A7
    Human Genome Epidemiology (HuGE) Navigator: SLC39A7 (9 documents)

    Export disorders for SLC39A7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC39A7 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with SLC39A7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. (PubMed id 15705588)1, 2, 3, 9 Huang L....Yu Y.Y. (J. Biol. Chem. 2005)
    2. cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. (PubMed id 8812499)1, 2, 3, 9 Ando A.... Inoko H. (Genomics 1996)
    3. Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters. (PubMed id 14525538)1, 2, 9 Taylor K.M....Nicholson R.I. (Biochem. J. 2004)
    4. Colinearity of novel genes in the class II regions of the MHC in mouse and human. (PubMed id 1855816)1, 3, 9 Hanson I.M. and Trowsdale J. (Immunogenetics 1991)
    5. Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7. (PubMed id 22317921)1, 2 Taylor K.M....Kille P. (Sci Signal 2012)
    6. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    7. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation. (PubMed id 19246244)1, 3 Hogstrand C....Taylor K.M. (Trends Mol Med 2009)
    10. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7922 HGNC: 4927 AceView: SLC39A7andHSD17B8 Ensembl:ENSG00000112473 euGenes: HUgn7922
    ECgene: SLC39A7 H-InvDB: SLC39A7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC39A7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC39A7 gene:
    Search GeneIP for patents involving SLC39A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SLC39A7   OriGene RNAi products in human, mouse, rat for SLC39A7  
     OriGene qPCR primer pairs and template standards for SLC39A7   OriGene Protein Over-expression Lysate for SLC39A7  
     OriGene MassSpec something-or-other for SLC39A7   OriGene clones in human, mouse for SLC39A7  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC39A7   OriGene Purified Protein for SLC39A7  
     OriGene ORF clones in mouse, rat for SLC39A7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC39A7   OriGene Custom Protein Services for SLC39A7  

     
     
     Block miRNA regulation of human, mouse, rat SLC39A7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC39A7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC39A7 Predesigned siRNA for gene silencing in human, mouse, rat SLC39A7
     QuantiFast Probe-based Assays in human, mouse, rat SLC39A7 QuantiTect SYBR Green Assays in human, mouse, rat SLC39A7
     Custom PCR Arrays for SLC39A7 Search Chromatin IP Primers for SLC39A7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC39A7  Search GeneGlobe Interaction Network for SLC39A7
     Regulatory tfbs in SLC39A7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC39A7 GenScript cDNA clones with any tag delivered in your preferred vector for SLC39A7
     GenScript Custom Assay Services for SLC39A7 GenScript Custom overexpressing Cell Line Services for SLC39A7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC39A7 (S39A7)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SLC39A7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC39A7 antibodies
     SLC39A7 proteins
     SLC39A7 lysates
     Antibodies for SLC39A7
     See all of Abcam's Antibodies, Kits and Proteins for SLC39A7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SLC39A7
     Antibodies for SLC39A7
     ELISAs for SLC39A7
     CLIAs for SLC39A7



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC39A7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A7
     SwitchGear 3'UTR luciferase reporter plasmids for SLC39A7
     SwitchGear Promoter luciferase reporter plasmids for SLC39A7
     ThermoFisher Antibodies for SLC39A7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC39A7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC39A7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC39A7
     LSBio Antibodies in human, mouse, rat for SLC39A7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SLC39A7
      Search eBioscience for proteins for SLC39A7
      Search eBioscience for elisas for SLC39A7
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC39A7 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4