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Aliases for SLC39A7 Gene

Aliases for SLC39A7 Gene

  • Solute Carrier Family 39 Member 7 2 3 4 5
  • Solute Carrier Family 39 (Zinc Transporter), Member 7 2 3
  • HLA Class II Region Expressed Gene KE4 2 3
  • Really Interesting New Gene 5 Protein 3 4
  • Histidine-Rich Membrane Protein Ke4 3 4
  • Zrt-, Irt-Like Protein 7 3 4
  • RING5 3 4
  • HKE4 3 4
  • ZIP7 3 4
  • Ke4 Gene, Mouse, Human Homolog Of 3
  • Zinc Transporter SLC39A7 3
  • D6S2244E 3
  • D6S115E 3
  • H2-KE4 3
  • KE4 3

External Ids for SLC39A7 Gene

Previous HGNC Symbols for SLC39A7 Gene

  • HKE4

Previous GeneCards Identifiers for SLC39A7 Gene

  • GC06P033215
  • GC06P033276
  • GC06P033168
  • GC06P032910

Summaries for SLC39A7 Gene

Entrez Gene Summary for SLC39A7 Gene

  • The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for SLC39A7 Gene

SLC39A7 (Solute Carrier Family 39 Member 7) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. GO annotations related to this gene include metal ion transmembrane transporter activity. An important paralog of this gene is SLC39A13.

UniProtKB/Swiss-Prot for SLC39A7 Gene

  • Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+).

Gene Wiki entry for SLC39A7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A7 Gene

Genomics for SLC39A7 Gene

Regulatory Elements for SLC39A7 Gene

Enhancers for SLC39A7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G033016 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -181.6 -181578 5.0 PKNOX1 ZNF493 ARID4B SIN3A ZNF2 YY1 ZNF121 GLIS2 ZNF143 KLF7 HCG25 HLA-DQA2 PPT2 HLA-DPB1 HLA-DPA1 RXRB HLA-DQB2 HLA-DMA COL11A2 BRD2
GH06G033061 1.5 FANTOM5 ENCODE dbSUPER 11.1 -138.3 -138271 0.7 HDGF TBP FOXA2 ATF1 ELK1 CBX5 ZNF143 ZNF207 RELB IKZF2 HLA-DPA1 HLA-DQB1 TAP1 PSMB9 RNY4P10 RXRB SLC39A7 HSD17B8 MIR219A1 HLA-DPB1
GH06G032984 1.5 Ensembl ENCODE dbSUPER 10.2 -215.6 -215558 1.3 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF2 SLC30A9 GLIS2 ZNF207 ZNF143 HLA-DMB ENSG00000250264 TAP2 TAP1 PSMB9 RXRB HSD17B8 SLC39A7 RNY4P10 MIR219A1
GH06G032982 1.3 Ensembl ENCODE dbSUPER 10.2 -216.9 -216918 1.4 HDGF FOXA2 SIN3A BMI1 FEZF1 CEBPG ZNF101 ZNF664 ZNF316 POLR2A HLA-DMA HLA-DMB TAP2 ENSG00000250264 TAP1 PSMB9 RXRB RNY4P10 SLC39A7 HSD17B8
GH06G032983 1.1 ENCODE dbSUPER 10.2 -217.9 -217887 0.2 KLF1 SIN3A BMI1 FEZF1 CEBPG BCL11B POLR2A SCRT2 KLF8 BCLAF1 HLA-DMB TAP2 ENSG00000250264 TAP1 PSMB9 RXRB RNY4P10 SLC39A7 HSD17B8 MIR219A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC39A7 on UCSC Golden Path with GeneCards custom track

Promoters for SLC39A7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195764 155 2001 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 SSRP1
ENSR00000320339 -1145 201 ZNF362 GLIS1

Transcription factor binding sites by QIAGEN in the SLC39A7 gene promoter:

Genomic Location for SLC39A7 Gene

Chromosome:
6
Start:
33,200,445 bp from pter
End:
33,204,439 bp from pter
Size:
3,995 bases
Orientation:
Plus strand

Genomic View for SLC39A7 Gene

Genes around SLC39A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for SLC39A7 Gene

  • Protein details for SLC39A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92504-S39A7_HUMAN
    Recommended name:
    Zinc transporter SLC39A7
    Protein Accession:
    Q92504
    Secondary Accessions:
    • B0UXF6
    • Q5STP8
    • Q9UIQ0

    Protein attributes for SLC39A7 Gene

    Size:
    469 amino acids
    Molecular mass:
    50118 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC39A7 Gene

Post-translational modifications for SLC39A7 Gene

  • Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release.
  • Ubiquitination at Lys310
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC39A7 Gene

No data available for DME Specific Peptides for SLC39A7 Gene

Domains & Families for SLC39A7 Gene

Gene Families for SLC39A7 Gene

Protein Domains for SLC39A7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC39A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92504

UniProtKB/Swiss-Prot:

S39A7_HUMAN :
  • Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
genes like me logo Genes that share domains with SLC39A7: view

Function for SLC39A7 Gene

Molecular function for SLC39A7 Gene

UniProtKB/Swiss-Prot Function:
Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+).
UniProtKB/Swiss-Prot Induction:
Down-regulated by Zn(+2).

Gene Ontology (GO) - Molecular Function for SLC39A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity TAS --
GO:0005515 protein binding IPI 22317921
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A7: view
genes like me logo Genes that share phenotypes with SLC39A7: view

Animal Models for SLC39A7 Gene

MGI Knock Outs for SLC39A7:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC39A7

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC39A7 Gene

Localization for SLC39A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A7 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC39A7 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
plasma membrane 3
golgi apparatus 3
peroxisome 1
cytosol 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for SLC39A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IDA,IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane TAS 8812499
genes like me logo Genes that share ontologies with SLC39A7: view

Pathways & Interactions for SLC39A7 Gene

genes like me logo Genes that share pathways with SLC39A7: view

Gene Ontology (GO) - Biological Process for SLC39A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006829 zinc II ion transport IEA --
GO:0006882 cellular zinc ion homeostasis IBA --
GO:0030001 metal ion transport IEA --
genes like me logo Genes that share ontologies with SLC39A7: view

No data available for SIGNOR curated interactions for SLC39A7 Gene

Drugs & Compounds for SLC39A7 Gene

(1) Drugs for SLC39A7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SLC39A7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC39A7: view

Transcripts for SLC39A7 Gene

Unigene Clusters for SLC39A7 Gene

Solute carrier family 39 (zinc transporter), member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3: - -

Relevant External Links for SLC39A7 Gene

GeneLoc Exon Structure for
SLC39A7
ECgene alternative splicing isoforms for
SLC39A7

Expression for SLC39A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC39A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC39A7 Gene

This gene is overexpressed in Nasal epithelium (23.7) and Fetal gut (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC39A7 Gene



Protein tissue co-expression partners for SLC39A7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC39A7 Gene:

SLC39A7

SOURCE GeneReport for Unigene cluster for SLC39A7 Gene:

Hs.631995

mRNA Expression by UniProt/SwissProt for SLC39A7 Gene:

Q92504-S39A7_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for SLC39A7 Gene

  • Liver(4.4)
  • Kidney(4.3)
  • Blood(4.2)
  • Skin(4.2)
  • Nervous system(3.6)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with SLC39A7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC39A7 Gene

Orthologs for SLC39A7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC39A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC39A7 34 35
  • 98.91 (n)
cow
(Bos Taurus)
Mammalia SLC39A7 34 35
  • 90.41 (n)
dog
(Canis familiaris)
Mammalia SLC39A7 34 35
  • 90.41 (n)
mouse
(Mus musculus)
Mammalia Slc39a7 34 16 35
  • 84.05 (n)
rat
(Rattus norvegicus)
Mammalia Slc39a7 34
  • 83.15 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC39A7 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a7 34
  • 64.04 (n)
Str.13 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.19342 34
zebrafish
(Danio rerio)
Actinopterygii slc39a7 34 35
  • 63.27 (n)
ke4 34
fruit fly
(Drosophila melanogaster)
Insecta Catsup 35
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hke-4.2 34 35
  • 56.81 (n)
hke-4.1 35
  • 46 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL096W 34
  • 46.85 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKE4 34 35 37
  • 44.4 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17886g 34
  • 42.79 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons IAR1 34
  • 47.23 (n)
rice
(Oryza sativa)
Liliopsida Os08g0467400 34
  • 50.53 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06380 34
  • 49.21 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAP8A3.03 34
  • 44.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3262 34
Species where no ortholog for SLC39A7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A7 Gene

ENSEMBL:
Gene Tree for SLC39A7 (if available)
TreeFam:
Gene Tree for SLC39A7 (if available)

Paralogs for SLC39A7 Gene

genes like me logo Genes that share paralogs with SLC39A7: view

Variants for SLC39A7 Gene

Sequence variations from dbSNP and Humsavar for SLC39A7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000076425 -- 33,204,090(+) GACAG(A/G)GGGTG upstream-variant-2KB, utr-variant-3-prime
rs1000424042 -- 33,204,059(+) GCTAA(A/G)TGGGG upstream-variant-2KB, utr-variant-3-prime
rs1001951266 -- 33,201,835(+) GCTCT(C/G)TACTT upstream-variant-2KB, reference, missense
rs1002841616 -- 33,200,610(+) GTCGC(C/T)CTGCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1002954205 -- 33,200,336(+) GCCGC(C/T)GCTGC intron-variant, upstream-variant-2KB, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC39A7 Gene

Variant ID Type Subtype PubMed ID
dgv10609n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv522719 CNV loss 19592680
nsv830634 CNV loss 17160897

Variation tolerance for SLC39A7 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.22; 62.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC39A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC39A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A7 Gene

Disorders for SLC39A7 Gene

Relevant External Links for SLC39A7

Genetic Association Database (GAD)
SLC39A7
Human Genome Epidemiology (HuGE) Navigator
SLC39A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC39A7

No disorders were found for SLC39A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A7 Gene

Publications for SLC39A7 Gene

  1. The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. (PMID: 15705588) Huang L. … Yu Y.Y. (J. Biol. Chem. 2005) 2 3 4 22 64
  2. cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. (PMID: 8812499) Ando A. … Inoko H. (Genomics 1996) 2 3 4 22 64
  3. Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters. (PMID: 14525538) Taylor K.M. … Nicholson R.I. (Biochem. J. 2004) 3 4 22 64
  4. Colinearity of novel genes in the class II regions of the MHC in mouse and human. (PMID: 1855816) Hanson I.M. … Trowsdale J. (Immunogenetics 1991) 2 3 22 64
  5. Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7. (PMID: 22317921) Taylor K.M. … Kille P. (Sci Signal 2012) 3 4 64

Products for SLC39A7 Gene

Sources for SLC39A7 Gene

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