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SLC39A6 Gene

protein-coding   GIFtS: 57
GCID: GC18M033688

Solute Carrier Family 39 (Zinc Transporter), Member 6

(Previous names: solute carrier family 39 (metal ion transporter), member...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 61 2     LIV-12
Solute Carrier Family 39 (Metal Ion Transporter), Member 61 2     LIV-1 Protein, Estrogen Regulated2
Estrogen-Regulated Protein LIV-12 3     Zinc Transporter ZIP62
Solute Carrier Family 39 Member 62 3     LIV13
Zrt- And Irt-Like Protein 62 3     ZIP63
ZIP-62 3     

External Ids:    HGNC: 186071   Entrez Gene: 258002   Ensembl: ENSG000001414247   OMIM: 6087315   UniProtKB: Q134333   

Export aliases for SLC39A6 gene to outside databases

Previous GC identifers: GC18M033576 GC18M031941 GC18M031940 GC18M031943 GC18M030547


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC39A6 Gene:
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and
lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation.
SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and
Nicholson, 2003 (PubMed 12659941)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC39A6 Gene:
SLC39A6 (solute carrier family 39 (zinc transporter), member 6) is a protein-coding gene. Diseases associated with SLC39A6 include endometrial carcinoma, and esophageal squamous cell carcinoma. GO annotations related to this gene include zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A10.

UniProtKB/Swiss-Prot: S39A6_HUMAN, Q13433
Function: May act as a zinc-influx transporter

Gene Wiki entry for SLC39A6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC39A6 gene promoter:
         FOXO3   GATA-1   FOXO3b   Roaz   POU2F1   CP2   FOXO4   POU2F1a   STAT3   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC39A6 promoter sequence
   Search Chromatin IP Primers for SLC39A6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC39A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.2   Ensembl cytogenetic band:  18q12.2   HGNC cytogenetic band: 18q12.2

SLC39A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A6 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M033688:  view genomic region     (about GC identifiers)

Start:
33,688,494 bp from pter      End:
33,709,357 bp from pter
Size:
20,864 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: S39A6_HUMAN, Q13433 (See protein sequence)
Recommended Name: Zinc transporter ZIP6 precursor  
Size: 755 amino acids; 85047 Da
Sequence caution: Sequence=BAG61161.1; Type=Erroneous initiation;
Secondary accessions: B4DR49 B4E224 Q8IXR3 Q96HP5
Alternative splicing: 2 isoforms:  Q13433-1   Q13433-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC39A6: NX_Q13433

Explore proteomics data for SLC39A6 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Ubiquitination2 at Lys77
  • Glycosylation2 at Asn67, Asn68, Ser196, Ser219, Ser221, Thr222, Ser225, Thr227, Ser228, Asn241,
                                 Asn266, Asn283, Asn684
  • Modification sites at PhosphoSitePlus

  • See SLC39A6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001092876.1  NP_036451.3  

    ENSEMBL proteins: 
     ENSP00000269187   ENSP00000465915   ENSP00000401139   ENSP00000467724  
    Reactome Protein details: Q13433

    SLC39A6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SLC39A6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 6
    SLC39 family of metal ion transporters

    1 InterPro protein domain:
     IPR003689 ZIP

    Graphical View of Domain Structure for InterPro Entry Q13433

    ProtoNet protein and cluster: Q13433

    1 Blocks protein domain: IPB003689 Zinc transporter ZIP

    UniProtKB/Swiss-Prot: S39A6_HUMAN, Q13433
    Similarity: Belongs to the ZIP transporter (TC 2.A.5) family


    SLC39A6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S39A6_HUMAN, Q13433
    Function: May act as a zinc-influx transporter
    Induction: Up-regulated by estrogen in breast cancer cells lines

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005385zinc ion transmembrane transporter activity IDA15642354
    GO:0046873metal ion transmembrane transporter activity ----
         
    SLC39A6 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Slc39a6 (no phenotypes)

    SLC39A6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc39a6tm1Lex for SLC39A6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC39A6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC39A6
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    miRNA
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    miRTarBase miRNAs that target SLC39A6:
    hsa-mir-26b-5p (MIRT029131), hsa-mir-32-5p (MIRT028339)

    Block miRNA regulation of human, mouse, rat SLC39A6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC39A6 (see all 33):
    hsa-miR-582-3p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-25 hsa-miR-192 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidSLC39A6 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S39A6_HUMAN, Q13433: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA15642354
    GO:0016020membrane ----
    GO:0031258lamellipodium membrane IDA12839489

    SLC39A6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC39A6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    2Metal ion SLC transporters
    Metal ion SLC transporters
    Zinc influx into cells by the SLC39 gene family0.00
    Zinc transporters0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC39A6
        Zinc influx into cells by the SLC39 gene family



    SLC39A6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC39A6: 
              Breast Cancer in human mouse rat
              Hepatotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC39A6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for SLC39A6 (Q134333 ENSP000002691874) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KDM5BQ9UGL13, ENSP000003562344I2D: score=1 STRING: ENSP00000356234
    ETS1ENSP000003764364STRING: ENSP00000376436
    ETS2ENSP000003533444STRING: ENSP00000353344
    SLC30A4ENSP000002618674STRING: ENSP00000261867
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006882cellular zinc ion homeostasis IDA15642354
    GO:0030001metal ion transport ----
    GO:0055085transmembrane transport TAS--
    GO:0071577zinc ion transmembrane transport IMP12839489
    GO:0071578zinc ion transmembrane import IDA15642354

    SLC39A6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC39A6 (S39A6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC39A6 gene (2 alternative transcripts): 
    NM_001099406.1  NM_012319.3  

    Unigene Cluster for SLC39A6:

    Solute carrier family 39 (zinc transporter), member 6
    Hs.79136  [show with all ESTs]
    Unigene Representative Sequence: NM_012319
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269187(uc010dmy.3) ENST00000590986 ENST00000440549(uc002kzj.2)
    ENST00000586829
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC39A6 (see all 33):
    hsa-miR-582-3p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-25 hsa-miR-192 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidSLC39A6 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC39A6
      QuantiFast Probe-based Assays in human, mouse, rat SLC39A6

    Additional mRNA sequence: 

    AK299102.1 AK301539.1 AK304079.1 BC008317.2 BC039498.1 U41060.2 

    12 DOTS entries:

    DT.100652719  DT.316412  DT.95162541  DT.95162538  DT.91757571  DT.100699570  DT.100837043  DT.121088571 
    DT.121088626  DT.95325311  DT.97767795  DT.99963964 

    Selected AceView cDNA sequences (see all 255):

    BC008317 BM721841 AA781971 AI680554 AI954446 BC039498 BM456317 BQ013982 
    AI240664 AA165592 BF593420 AW771378 AI399726 AI394196 CB158727 BX329506 
    BX336036 CA488910 BE220923 AI979190 AI702103 CA443894 AL045657 AI418097 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A6    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
    SP1:                    -     -     -     -                                                               
    SP2:                                                                                                      
    SP3:                                                                                            -         
    SP4:                                                                                                      
    SP5:                    -                                                                                 


    ECgene alternative splicing isoforms for SLC39A6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC39A6 expression in normal human tissues (normalized intensities)      SLC39A6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCTAAAA
    SLC39A6 Expression
    About this image


    SLC39A6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Brain (Nervous System)
             Cerebellum
    SLC39A6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC39A6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.79136

    UniProtKB/Swiss-Prot: S39A6_HUMAN, Q13433
    Tissue specificity: Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum.
    Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the
    cervix and lung carcinoma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC39A6: 
              Breast Cancer in human mouse rat
              Hepatotoxicity in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for SLC39A6
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC39A6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC39A6
    QuantiTect SYBR Green Assays in human, mouse, rat SLC39A6
    QuantiFast Probe-based Assays in human, mouse, rat SLC39A6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC39A6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc39a61 , 5 solute carrier family 39 (metal ion transporter), member more1, 5 84.53(n)1
    87.93(a)1
      18 (13.18 cM)5
    1069571  NM_139143.31  NP_631882.21 
     245798815 
    chicken
    (Gallus gallus)
    Aves SLC39A61 solute carrier family 39 (zinc transporter), member more 70.4(n)
    69.47(a)
      420984  XM_419071.3  XP_419071.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC39A66
    solute carrier family 39 (zinc transporter), membe...
    69(a)
    1 ↔ 1
    4(67584006-67609063)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004873491 zinc transporter ZIP6-like 67.12(n)
    67.81(a)
      100487349  XM_002935278.2  XP_002935324.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc39a61 solute carrier family 39 (zinc transporter), member more 62.58(n)
    61.96(a)
      324303  NM_001001591.1  NP_001001591.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta foi6
    fear-of-intimacy
    26(a)
    1 → many
    3L(8518344-8527084)


    ENSEMBL Gene Tree for SLC39A6 (if available)
    TreeFam Gene Tree for SLC39A6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC39A6 gene
    SLC39A102  SLC39A52  SLC39A82  SLC39A122  SLC39A42  SLC39A142  SLC39A132  SLC39A72  
    1 SIMAP similar gene for SLC39A6 using alignment to 2 protein entries:     S39A6_HUMAN (see all proteins):
    SLC39A10

    SLC39A6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC39A6 (see all 537)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447350581,2
    --33680947(+) GAGTGC/TAGAAT 1 -- ds50010--------
    rs728868411,2
    C--33681007(+) AAAAAA/GAGAGA 1 -- ds50010--------
    rs2006569091,2
    C--33681009(-) TCTCTC/TTTTTT 1 -- ds50010--------
    rs38266011,2
    C,F,H--33681042(+) CAATAT/GTTTTT 1 -- ds500112Minor allele frequency- G:0.12NA NS EA WA 922
    rs116654661,2
    C,F,H--33681054(+) AAGTGC/TCCTTT 1 -- ds500119Minor allele frequency- T:0.04NS EA NA WA CSA 1461
    rs1826507421,2
    --33681107(+) TATTAC/TAAATG 1 -- ds50010--------
    rs38266021,2
    C,F--33681254(+) CAGTGC/TTGCAG 1 -- ds500111Minor allele frequency- T:0.20NA WA CSA EA 372
    rs38266031,2
    C,F,H--33681261(+) GCAGGA/GTGAAG 1 -- ds50018Minor allele frequency- G:0.20NA WA EA 368
    rs739467721,2
    C--33681352(+) AAAAAT/ATTTTT 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1922540001,2
    --33681360(+) TTTTTA/TAAAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC39A6 (33688494 - 33709357 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC39A6: --
    Human Gene Mutation Database (HGMD): SLC39A6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC39A6
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC39A6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608731    OMIM disorders: --

    13 diseases for SLC39A6:    About MalaCards
    endometrial carcinoma    esophageal squamous cell carcinoma    alzheimer's disease    cervicitis
    prostatitis    esophagitis    prostate cancer    breast cancer
    squamous cell carcinoma    adenocarcinoma    hepatocellular carcinoma    pancreatitis
    leukemia


    SLC39A6 for disorders           About GeneDecksing


    Export disorders for SLC39A6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC39A6 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with SLC39A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters. (PubMed id 12839489)1, 2, 3, 9 Taylor K.M.... Nicholson R.I. (Biochem. J. 2003)
    2. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PubMed id 12659941)1, 3, 9 Taylor K.M. and Nicholson R.I. (Biochim. Biophys. Acta 2003)
    3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75- 1 human breast cancer cell line. (PubMed id 2903103)1, 2 Manning D.L.... Green C.D. (Mol. Cell. Endocrinol. 1988)
    6. Concordant correlation of LIV-1 and E-cadherin expression in human breast cancer cell MCF-7. (PubMed id 18330719)1, 9 Shen H....Guo J. (Mol. Biol. Rep. 2009)
    7. LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway. (PubMed id 17825787)1, 9 Zhao L....Li X. (Biochem. Biophys. Res. Commun. 2007)
    8. Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma. (PubMed id 23644492)1 Wu C....Lin D. (Nat. Genet. 2013)
    9. Negative correlation of LIV-1 and E-cadherin expression in hepatocellular carcinoma cells. (PubMed id 23437163)1 Shen R....Yang J. (PLoS ONE 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25800 HGNC: 18607 AceView: SLC39A6 Ensembl:ENSG00000141424 euGenes: HUgn25800
    ECgene: SLC39A6 H-InvDB: SLC39A6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC39A6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC39A6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC39A6 gene:
    Search GeneIP for patents involving SLC39A6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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