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Aliases for SLC39A6 Gene

Aliases for SLC39A6 Gene

  • Solute Carrier Family 39 Member 6 2 3 4
  • Solute Carrier Family 39 (Zinc Transporter), Member 6 2 3 5
  • Solute Carrier Family 39 (Metal Ion Transporter), Member 6 2 3
  • Estrogen-Regulated Protein LIV-1 3 4
  • Zrt- And Irt-Like Protein 6 3 4
  • ZIP-6 3 4
  • ZIP6 3 4
  • LIV-1 Protein, Estrogen Regulated 3
  • LIV-1 3
  • LIV1 4

External Ids for SLC39A6 Gene

Previous GeneCards Identifiers for SLC39A6 Gene

  • GC18M033576
  • GC18M031941
  • GC18M031940
  • GC18M031943
  • GC18M033688
  • GC18M030547

Summaries for SLC39A6 Gene

Entrez Gene Summary for SLC39A6 Gene

  • Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC39A6 Gene

SLC39A6 (Solute Carrier Family 39 Member 6) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. GO annotations related to this gene include metal ion transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A12.

UniProtKB/Swiss-Prot for SLC39A6 Gene

  • May act as a zinc-influx transporter.

Gene Wiki entry for SLC39A6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A6 Gene

Genomics for SLC39A6 Gene

Regulatory Elements for SLC39A6 Gene

Promoters for SLC39A6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC39A6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC39A6 Gene

Chromosome:
18
Start:
36,108,531 bp from pter
End:
36,129,814 bp from pter
Size:
21,284 bases
Orientation:
Minus strand

Genomic View for SLC39A6 Gene

Genes around SLC39A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A6 Gene

Proteins for SLC39A6 Gene

  • Protein details for SLC39A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13433-S39A6_HUMAN
    Recommended name:
    Zinc transporter ZIP6
    Protein Accession:
    Q13433
    Secondary Accessions:
    • B4DR49
    • B4E224
    • Q8IXR3
    • Q96HP5

    Protein attributes for SLC39A6 Gene

    Size:
    755 amino acids
    Molecular mass:
    85047 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG61161.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC39A6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A6 Gene

Proteomics data for SLC39A6 Gene at MOPED

Post-translational modifications for SLC39A6 Gene

  • N-glycosylated.
  • Ubiquitination at Lys 77
  • Glycosylation at Asn 67, Asn 68, Ser 196, Ser 219, Ser 221, Thr 222, Ser 225, Thr 227, Ser 228, Asn 241, Asn 266, Asn 283, and Asn 684
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC39A6 Gene

Antibody Products

No data available for DME Specific Peptides for SLC39A6 Gene

Domains & Families for SLC39A6 Gene

Gene Families for SLC39A6 Gene

Protein Domains for SLC39A6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC39A6 Gene

Graphical View of Domain Structure for InterPro Entry

Q13433

UniProtKB/Swiss-Prot:

S39A6_HUMAN :
  • Belongs to the ZIP transporter (TC 2.A.5) family.
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A6: view

Function for SLC39A6 Gene

Molecular function for SLC39A6 Gene

UniProtKB/Swiss-Prot Function:
May act as a zinc-influx transporter.
UniProtKB/Swiss-Prot Induction:
Up-regulated by estrogen in breast cancer cells lines.
genes like me logo Genes that share phenotypes with SLC39A6: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC39A6 Gene

Localization for SLC39A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC39A6 Gene COMPARTMENTS Subcellular localization image for SLC39A6 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC39A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane IEA --
GO:0031258 lamellipodium membrane IDA 12839489
genes like me logo Genes that share ontologies with SLC39A6: view

Pathways & Interactions for SLC39A6 Gene

genes like me logo Genes that share pathways with SLC39A6: view

Gene Ontology (GO) - Biological Process for SLC39A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
GO:0071577 zinc II ion transmembrane transport IMP 12839489
genes like me logo Genes that share ontologies with SLC39A6: view

No data available for SIGNOR curated interactions for SLC39A6 Gene

Drugs & Compounds for SLC39A6 Gene

No Compound Related Data Available

Transcripts for SLC39A6 Gene

Unigene Clusters for SLC39A6 Gene

Solute carrier family 39 (zinc transporter), member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - - - -
SP2:
SP3: -
SP4:
SP5: -

Relevant External Links for SLC39A6 Gene

GeneLoc Exon Structure for
SLC39A6
ECgene alternative splicing isoforms for
SLC39A6

Expression for SLC39A6 Gene

mRNA expression in normal human tissues for SLC39A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC39A6 Gene

This gene is overexpressed in Fetal Brain (33.9) and Frontal cortex (25.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC39A6 Gene



SOURCE GeneReport for Unigene cluster for SLC39A6 Gene Hs.79136

mRNA Expression by UniProt/SwissProt for SLC39A6 Gene

Q13433-S39A6_HUMAN
Tissue specificity: Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.
genes like me logo Genes that share expression patterns with SLC39A6: view

Protein tissue co-expression partners for SLC39A6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC39A6 Gene

Orthologs for SLC39A6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC39A6 35
  • 92.88 (n)
  • 97.68 (a)
SLC39A6 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC39A6 35
  • 91.97 (n)
  • 93.3 (a)
SLC39A6 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc39a6 35
  • 84.53 (n)
  • 87.93 (a)
Slc39a6 16
Slc39a6 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC39A6 35
  • 99.43 (n)
  • 99.21 (a)
SLC39A6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc39a6 35
  • 85.46 (n)
  • 88.86 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC39A6 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC39A6 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC39A6 35
  • 70.4 (n)
  • 69.47 (a)
SLC39A6 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC39A6 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487349 35
  • 67.12 (n)
  • 67.81 (a)
zebrafish
(Danio rerio)
Actinopterygii slc39a6 35
  • 62.58 (n)
  • 61.96 (a)
slc39a6 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta foi 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for SLC39A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC39A6 Gene

ENSEMBL:
Gene Tree for SLC39A6 (if available)
TreeFam:
Gene Tree for SLC39A6 (if available)

Paralogs for SLC39A6 Gene

(1) SIMAP similar genes for SLC39A6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC39A6: view

Variants for SLC39A6 Gene

Sequence variations from dbSNP and Humsavar for SLC39A6 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1789528 - 36,126,651(-) TCAGA(C/G)CACGA intron-variant, reference, missense
rs14735 -- 36,108,618(+) GTATA(A/T)AAAAG utr-variant-3-prime
rs717250 -- 36,118,864(-) tactt(C/T)ccacc intron-variant
rs719147 -- 36,118,229(-) CCTTA(A/C)TACTT intron-variant
rs1050631 -- 36,114,157(-) CCACT(C/T)TGGCC reference, synonymous-codon

Variation tolerance for SLC39A6 Gene

Residual Variation Intolerance Score: 9.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC39A6 Gene

HapMap Linkage Disequilibrium report
SLC39A6
Human Gene Mutation Database (HGMD)
SLC39A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC39A6 Gene

Disorders for SLC39A6 Gene

Relevant External Links for SLC39A6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC39A6

No disorders were found for SLC39A6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A6 Gene

Publications for SLC39A6 Gene

  1. Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters. (PMID: 12839489) Taylor K.M. … Nicholson R.I. (Biochem. J. 2003) 2 3 4 23 67
  2. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PMID: 12659941) Taylor K.M. … Nicholson R.I. (Biochim. Biophys. Acta 2003) 2 3 23
  3. Concordant correlation of LIV-1 and E-cadherin expression in human breast cancer cell MCF-7. (PMID: 18330719) Shen H. … Guo J. (Mol. Biol. Rep. 2009) 3 23
  4. LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway. (PMID: 17825787) Zhao L. … Li X. (Biochem. Biophys. Res. Commun. 2007) 3 23
  5. Effect of LIV1 on the sensitivity of ovarian cancer cells to trichostatin A. (PMID: 25420545) Ma X. … Wang J. (Oncol. Rep. 2015) 3

Products for SLC39A6 Gene

Sources for SLC39A6 Gene

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