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Aliases for SLC39A6 Gene

Aliases for SLC39A6 Gene

  • Solute Carrier Family 39 (Zinc Transporter), Member 6 2 3
  • Solute Carrier Family 39 (Metal Ion Transporter), Member 6 2 3
  • Solute Carrier Family 39 Member 6 3 4
  • Estrogen-Regulated Protein LIV-1 3 4
  • Zrt- And Irt-Like Protein 6 3 4
  • ZIP-6 3 4
  • LIV-1 Protein, Estrogen Regulated 3
  • Zinc Transporter ZIP6 3
  • LIV-1 3
  • LIV1 4
  • ZIP6 4

External Ids for SLC39A6 Gene

Previous GeneCards Identifiers for SLC39A6 Gene

  • GC18M033576
  • GC18M031941
  • GC18M031940
  • GC18M031943
  • GC18M033688
  • GC18M030547

Summaries for SLC39A6 Gene

Entrez Gene Summary for SLC39A6 Gene

  • Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC39A6 Gene

SLC39A6 (Solute Carrier Family 39 (Zinc Transporter), Member 6) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A12.

UniProtKB/Swiss-Prot for SLC39A6 Gene

  • May act as a zinc-influx transporter.

Gene Wiki entry for SLC39A6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A6 Gene

Genomics for SLC39A6 Gene

Regulatory Elements for SLC39A6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC39A6 Gene

36,108,531 bp from pter
36,129,394 bp from pter
20,864 bases
Minus strand

Genomic View for SLC39A6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC39A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A6 Gene

Proteins for SLC39A6 Gene

  • Protein details for SLC39A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc transporter ZIP6
    Protein Accession:
    Secondary Accessions:
    • B4DR49
    • B4E224
    • Q8IXR3
    • Q96HP5

    Protein attributes for SLC39A6 Gene

    755 amino acids
    Molecular mass:
    85047 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAG61161.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC39A6 Gene


neXtProt entry for SLC39A6 Gene

Proteomics data for SLC39A6 Gene at MOPED

Post-translational modifications for SLC39A6 Gene

  • N-glycosylated.
  • Ubiquitination at Lys77
  • Glycosylation at Asn67, Asn68, Ser196, Ser219, Ser221, Thr222, Ser225, Thr227, Ser228, Asn241, Asn266, Asn283, and Asn684
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC39A6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC39A6 Gene

Domains for SLC39A6 Gene

Gene Families for SLC39A6 Gene

Protein Domains for SLC39A6 Gene


Suggested Antigen Peptide Sequences for SLC39A6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q13433
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A6: view

Function for SLC39A6 Gene

Molecular function for SLC39A6 Gene

UniProtKB/Swiss-Prot Function:
May act as a zinc-influx transporter.
UniProtKB/Swiss-Prot Induction:
Up-regulated by estrogen in breast cancer cells lines.

Gene Ontology (GO) - Molecular Function for SLC39A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity IDA 15642354
GO:0046873 metal ion transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC39A6: view

Animal Model Products

CRISPR Products

miRNA for SLC39A6 Gene

miRTarBase miRNAs that target SLC39A6

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC39A6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC39A6 Gene

Localization for SLC39A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC39A6 Gene COMPARTMENTS Subcellular localization image for SLC39A6 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for SLC39A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 15642354
GO:0009986 cell surface IDA 19581412
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SLC39A6: view

Pathways for SLC39A6 Gene

genes like me logo Genes that share pathways with SLC39A6: view

PCR Array Products

Gene Ontology (GO) - Biological Process for SLC39A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006882 cellular zinc ion homeostasis IDA 15642354
GO:0030001 metal ion transport --
GO:0055085 transmembrane transport TAS --
GO:0071577 zinc II ion transmembrane transport IMP 12839489
GO:0071578 zinc II ion transmembrane import IDA 15642354
genes like me logo Genes that share ontologies with SLC39A6: view

Transcripts for SLC39A6 Gene

Unigene Clusters for SLC39A6 Gene

Solute carrier family 39 (zinc transporter), member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC39A6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - - - -
SP3: -
SP5: -

Relevant External Links for SLC39A6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC39A6 Gene

mRNA expression in normal human tissues for SLC39A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SLC39A6 Gene

This gene is overexpressed in Fetal Brain (33.9) and Frontal cortex (25.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC39A6 Gene

SOURCE GeneReport for Unigene cluster for SLC39A6 Gene Hs.79136

mRNA Expression by UniProt/SwissProt for SLC39A6 Gene

Tissue specificity: Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.
genes like me logo Genes that share expressions with SLC39A6: view

Expression partners for SLC39A6 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC39A6 Gene

Orthologs for SLC39A6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC39A6 35
  • 92.88 (n)
  • 97.68 (a)
SLC39A6 36
  • 92 (a)
(Canis familiaris)
Mammalia SLC39A6 35
  • 91.97 (n)
  • 93.3 (a)
SLC39A6 36
  • 93 (a)
(Mus musculus)
Mammalia Slc39a6 35
  • 84.53 (n)
  • 87.93 (a)
Slc39a6 16
Slc39a6 36
  • 87 (a)
(Pan troglodytes)
Mammalia SLC39A6 35
  • 99.43 (n)
  • 99.21 (a)
SLC39A6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc39a6 35
  • 85.46 (n)
  • 88.86 (a)
(Monodelphis domestica)
Mammalia SLC39A6 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia SLC39A6 36
  • 72 (a)
(Gallus gallus)
Aves SLC39A6 35
  • 70.4 (n)
  • 69.47 (a)
SLC39A6 36
  • 69 (a)
(Anolis carolinensis)
Reptilia SLC39A6 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487349 35
  • 67.12 (n)
  • 67.81 (a)
(Danio rerio)
Actinopterygii slc39a6 35
  • 62.58 (n)
  • 61.96 (a)
slc39a6 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta foi 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for SLC39A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC39A6 Gene

Gene Tree for SLC39A6 (if available)
Gene Tree for SLC39A6 (if available)

Paralogs for SLC39A6 Gene

Selected SIMAP similar genes for SLC39A6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC39A6: view

Variants for SLC39A6 Gene

Sequence variations from dbSNP and Humsavar for SLC39A6 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs14735 -- 36,108,618(+) GTATA(A/T)AAAAG utr-variant-3-prime
rs717250 -- 36,118,864(-) tactt(C/T)ccacc intron-variant
rs719147 -- 36,118,229(-) CCTTA(A/C)TACTT intron-variant
rs1050631 -- 36,114,157(-) CCACT(C/T)TGGCC reference, synonymous-codon
rs1107840 -- 36,127,201(+) CTTGC(A/C)TTCCT intron-variant

Relevant External Links for SLC39A6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC39A6 Gene

Disorders for SLC39A6 Gene

No disorders were found for SLC39A6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SLC39A6 Gene

Publications for SLC39A6 Gene

  1. Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters. (PMID: 12839489) Taylor K.M. … Nicholson R.I. (Biochem. J. 2003) 2 3 4 23
  2. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PMID: 12659941) Taylor K.M. … Nicholson R.I. (Biochim. Biophys. Acta 2003) 2 3 23
  3. LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway. (PMID: 17825787) Zhao L. … Li X. (Biochem. Biophys. Res. Commun. 2007) 3 23
  4. Concordant correlation of LIV-1 and E-cadherin expression in human breast cancer cell MCF-7. (PMID: 18330719) Shen H. … Guo J. (Mol. Biol. Rep. 2009) 3 23
  5. Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75- 1 human breast cancer cell line. (PMID: 2903103) Manning D.L. … Green C.D. (Mol. Cell. Endocrinol. 1988) 3 4

Products for SLC39A6 Gene

Sources for SLC39A6 Gene

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