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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC39A4 Gene

protein-coding   GIFtS: 56
GCID: GC08M145637

solute carrier family 39 (zinc transporter), member 4

(Previous names: acrodermatitis enteropathica, zinc-deficiency type )
(Previous symbol: AEZ)
 Explore 11 diseases affiliated with
SLC39A4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC39A4    

Aliases
for SLC39A4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 41 2     Zrt- And Irt-Like Protein 42 3
ZIP41 2 3 5     ZIP-42 3
AEZ1 2     Acrodermatitis Enteropathica, Zinc-Deficiency Type1
AWMS21 2     Zinc Transporter ZIP42
Solute Carrier Family 39 Member 42 3     

External Ids:    HGNC: 171291   Entrez Gene: 556302   Ensembl: ENSG000001478047   OMIM: 6070595   UniProtKB: Q6P5W53   

Export aliases for SLC39A4 gene to outside databases

Previous GC identifers: GC08M143241 GC08M145675 GC08M145239 GC08M145642 GC08M145608 GC08M140751


Summaries
for SLC39A4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC39A4:
This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The transmembrane protein
is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica, a rare
inherited defect in the absorption of dietary zinc. Multiple transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5
Function: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc
availability (By similarity)




Genomic Views
for SLC39A4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_037704.5  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC39A4 gene promoter:
         Brachyury   NRSF form 1   NRSF form 2   GATA-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC39A4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC39A4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC39A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

SLC39A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145637:  view genomic region     (about GC identifiers)

Start:
 145,635,126 bp from pter      End:
 145,642,279 bp from pter
Size:
 7,154 bases      Orientation:
 minus strand

1 alternative location:
Chr8-,PATCHES 145,552,557-145,557,032     

Proteins
for SLC39A4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5 (See protein sequence)
Recommended Name: Zinc transporter ZIP4 precursor  
Size: 647 amino acids; 68392 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane
protein. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma
membrane in response to zinc availability
Sequence caution: Sequence=BAA91091.1; Type=Frameshift; Positions=573, 598, 618;
Secondary accessions: Q7L5S5 Q9H6T8 Q9NXC4
Alternative splicing: 2 isoforms:  Q6P5W5-1   Q6P5W5-2   

Explore the universe of human proteins at neXtProt for SLC39A4: NX_Q6P5W5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6P5W5

    • SLC39A4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_060237.2  NP_570901.2  

    ENSEMBL proteins: 
     ENSP00000276833   ENSP00000301305   ENSP00000434512  
    Reactome Protein details: Q6P5W5
    Human Recombinant Protein Products: 
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    Uscn Proteins for SLC39A4

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome ----
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IDA14612438


    SLC39A4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC39A4

    Protein Domains /
    Families
    for SLC39A4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC39A4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003689 ZIP

    Graphical View of Domain Structure for InterPro Entry Q6P5W5

    ProtoNet protein and cluster: Q6P5W5

    1 Blocks protein family: IPB003689 Zinc transporter ZIP

    UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5
    Similarity: Belongs to the ZIP transporter (TC 2.A.5) family


    Function
    for SLC39A4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5
    Function: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc
    availability (By similarity)

    miRNA
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005385zinc ion transmembrane transporter activity IEA--
    GO:0046873metal ion transmembrane transporter activity ----


    SLC39A4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLC39A4:
     Decreased viability with pacli 

    Animal Models:
         15 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slc39a4):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  liver/biliary system  mortality/aging 
     muscle  nervous system  other  skeleton  vision/eye 

    SLC39A4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC39A4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Zinc transporters
    		Zinc transporters1.00
    		Zinc influx into cells by the SLC39 gene family0.59
    		Metal ion SLC transporters0.68
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    3Senescence and Autophagy
    		Senescence and Autophagy1.00
    4Mineral absorption
    		Mineral absorption1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SLC39A4 
        Senescence and Autophagy

    5/6        Reactome Pathways for SLC39A4 (see all 6)
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Metal ion SLC transporters
    Zinc transporters


    1         Kegg Pathway  (Kegg details for SLC39A4):
        Mineral absorption


    SLC39A4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC39A4

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006882cellular zinc ion homeostasis IEA--
    GO:0034224cellular response to zinc ion starvation IEA--
    GO:0055085transmembrane transport TAS--
    GO:0071577zinc ion transmembrane transport ----


    SLC39A4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC39A4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC39A4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC39A4
    1 Novoseek chemical compound relationship for SLC39A4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 69.2 62 15358787 (8), 12801924 (6), 17483098 (5), 17202136 (4) (see all 11)

    Search CenterWatch for drugs/clinical trials and news about SLC39A4 / S39A4 

    Transcripts
    for SLC39A4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC39A4 gene (2 alternative transcripts): 
    NM_017767.2  NM_130849.2  

    Unigene Cluster for SLC39A4:

    Solute carrier family 39 (zinc transporter), member 4
    Hs.521934  [show with all ESTs]
    Unigene Representative Sequence: AK056900
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527148 ENST00000529462(uc003zcm.1) ENST00000530807 ENST00000532718(uc003zcn.3)
    ENST00000276833(uc003zcp.3) ENST00000301305(uc003zco.3 uc003zcq.3)
    ENST00000531013 ENST00000531789 ENST00000526658

    miRNA
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    Inhib. RNA
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    Browse OriGene siRNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK000334.1 AK000489.1 AK000695.1 AK025537.1 AK056900.1 AK290563.1 BC001688.2 BC062625.1 

    8 DOTS entries:

    DT.444715  DT.100779040  DT.95161761  DT.97861814  DT.95254719  DT.97861813  DT.95161762  DT.121469661 

    24/105 AceView cDNA sequences (see all 105):

    BQ671081 BM810871 BM796349 BU163061 AI634653 BQ680356 BM687088 BM914864 
    BG235988 BQ433248 AW015314 BX107695 BM423917 BQ677952 BF739887 BC001688 
    AA424487 AA946921 CR600637 BU181201 AK000489 BQ680943 BI906631 BE732073 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A4 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
    SP1:              -                                                     -                                                   
    SP2:                                                                    -                                                   
    SP3:                                                                    -                                                   
    SP4:                                                                                                              -         
    SP5:              -     -                                                                                                   


    ECgene alternative splicing isoforms for SLC39A4

    Expression
    for SLC39A4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC39A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCCCGGCGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC39A4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    TestisSeminiferous TubulesSertoli cellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC39A4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC39A4

    SOURCE GeneReport for Unigene cluster: Hs.521934

    UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5
    Tissue specificity: Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum

        SABiosciences Custom PCR Arrays for SLC39A4
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    In Situ
    Assay Products:     
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    Orthologs
    for SLC39A4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC39A4 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia SLC39A46
    		 --
    		 72(a)
    		 1 ↔ 1
    		 GL343636.1(1418-3338)
    zebrafish
    (Danio rerio)    		 Actinopterygii slc39a46
    		 solute carrier family 39 (zinc transporter), membe...
    		 66(a)
    		 1 ↔ 1
    		 19(1112201-1119410)
    worm
    (Caenorhabditis elegans)    		 Secernentea tag-1416
    		 Temporarily Assigned Gene name family member (tag-...
    		 25(a)
    		 possible ortholog
    		 IV(17364965-17366454)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons IAR16
    		 IAA-alanine resistance protein 1
    		 19(a)
    		 1 → many
    		 1(25521204-25524175)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 metal cation transporter, putative, expressed
    		 19(a)
    		 1 → many
    		 8(22984381-22992760)


    ENSEMBL Gene Tree for SLC39A4 (if available)
    TreeFam Gene Tree for SLC39A4 (if available) 

    Paralogs
    for SLC39A4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC39A4 gene
    SLC39A102  SLC39A52  SLC39A82  SLC39A62  SLC39A122  SLC39A142  SLC39A132  SLC39A72  
    3 SIMAP similar genes for SLC39A4 using alignment to 3 protein entries:     S39A4_HUMAN (see all proteins):
    SLC39A12    SLC39A8    SLC39A14

    SLC39A4 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC39A4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/244 NCBI SNPs in SLC39A4 are shown (see all 244)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1214342871,2
    		Cpathogenic142083288(-) CTTGCC/TGAGCC 4 P L mis10--------
    rs43264171,2
    		C,H--140751385(+) TCGCAA/G/TAGTGC 6 L syn1 ese37NS EA NA 4890
    rs29778401,2
    		--140751801(-) ctgggA/Cgggga 2 -- int10--------
    rs45279211,2
    		H--140752671(+) GGCTGT/AGGGCT 4 /P syn1 ese34Minor allele frequency- A:0.00NS EA 416
    rs45357701,2
    		C,H--140752709(+) CCCCAG/ACACCT 4 /L syn15Minor allele frequency- A:0.00NS EA NA 416
    rs30214461,2
    		H--140752767(-) TGGGTC/TTTGGT 2 -- int14Minor allele frequency- T:0.00NS EA 416
    rs49923171,2
    		H--140752773(+) ACCCAG/AGGAGA 2 -- int1 trp34Minor allele frequency- A:0.00NS EA 404
    rs49923181,2
    		H--140752803(+) GGTAAG/AGTCCC 2 -- int14Minor allele frequency- A:0.00NS EA 418
    rs18715351,2
    		C,F,A,H,--140752819(-) AGGCCA/GTGCCC 2 -- int112Minor allele frequency- G:0.26NS NA WA CSA 384
    rs44831981,2
    		H--140752896(+) ATGCAG/CGACAG 4 /L /V mis1 ese36Minor allele frequency- C:0.00NS EA NA 424

    HapMap Linkage Disequilibrium report for SLC39A4 (145635126 - 145642279 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for SLC39A4
         6 CNVs: 30308 4613 3752 53129 30309 30306
    Human Gene Mutation Database (HGMD): SLC39A4

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SLC39A4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC39A4 for disorders           About GeneDecksing

    OMIM gene information: 607059   
    OMIM disorders: 201100  
    UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5
  • Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ) [MIM:201100]. AEZ
    • is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinical features are
    growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental
    disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is
    fatal

    11 diseases for SLC39A4:    About MalaCards
    acrodermatitis enteropathica    enteropathica    acrodermatitis    autosomal recessive disease
    mental disorders    alopecia    diarrhea    dermatitis
    pancreatic cancer    pancreatitis    carcinoma

    3 diseases from the University of Copenhagen DISEASES database for SLC39A4:
    Acrodermatitis enteropathica     Acrodermatitis     Genetic disorder

    3 Novoseek disease relationships for SLC39A4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acrodermatitis enteropathica 97.9 25 12801924 (3), 12787121 (3), 17483098 (2), 20300938 (2) (see all 13)
    zinc deficiency 85.3 7 15358787 (3), 17483098 (2), 12801924 (1)
    genetic disorder 61.2 5 12801924 (1), 17483098 (1), 14709598 (1), 15358787 (1)

    Human Genome Epidemiology (HuGE) Navigator: SLC39A4 (2 documents)

    Export disorders for SLC39A4 gene to outside databases

    Publications
    for SLC39A4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC39A4 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with SLC39A4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice. (PubMed id 12801924)1, 3, 9 Dufner-Beattie J....Andrews G.K. (2003)
    2. Acrodermatitis enteropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter. (PubMed id 14709598)1, 3, 9 Wang F....Eide D.J. (2004)
    3. Novel SLC39A4 mutations in acrodermatitis enteropathica. (PubMed id 12787121)1, 2, 9 Nakano A.... Hanada K. (2003)
    4. Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane. (PubMed id 14612438)1, 2, 9 Kim B.-E....Petris M.J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PubMed id 12659941)1, 3 Taylor K.M. and Nicholson R.I. (2003)
    8. Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. (PubMed id 12068297)1, 2 Kuery S....Moisan J.-P. (2002)
    9. A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. (PubMed id 12032886)1, 2 Wang K.... Gitschier J. (2002)
    10. Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. (PubMed id 18003899)1, 9 Li M....Yao Q. (2007)

    External Searches for SLC39A4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing SLC39A4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55630 HGNC: 17129 AceView: SLC39A4 Ensembl:ENSG00000147804 euGenes: HUgn55630
    ECgene: SLC39A4 Kegg: 55630 H-InvDB: SLC39A4

    Other Databases showing SLC39A4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC39A4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC39A4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC39A4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC39A4 gene:
    Search GeneIP for patents involving SLC39A4

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