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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC39A4 Gene

protein-coding   GIFtS: 59
GCID: GC08M145637

Solute Carrier Family 39 (Zinc Transporter), Member 4

(Previous names: acrodermatitis enteropathica, zinc-deficiency type)
(Previous symbol: AEZ)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 41 2     AWMS22
ZIP42 3 5     Zinc Transporter ZIP42
AEZ1 2     ZIP-43
Zrt- And Irt-Like Protein 42 3     Solute Carrier Family 39 Member 43
Acrodermatitis Enteropathica, Zinc-Deficiency Type1     

External Ids:    HGNC: 171291   Entrez Gene: 556302   Ensembl: ENSG000001478047   OMIM: 6070595   UniProtKB: Q6P5W53   

Export aliases for SLC39A4 gene to outside databases

Previous GC identifers: GC08M143241 GC08M145675 GC08M145239 GC08M145642 GC08M145608 GC08M140751


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC39A4 Gene:
This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein
localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in
acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jul 2013)

GeneCards Summary for SLC39A4 Gene: 
SLC39A4 (solute carrier family 39 (zinc transporter), member 4) is a protein-coding gene. Diseases associated with SLC39A4 include enteropathica, and acrodermatitis, and among its related super-pathways are Zinc transporters and Transmembrane transport of small molecules. GO annotations related to this gene include zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A10.

UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5
Function: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to
zinc availability (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_037704.5  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC39A4 gene promoter:
         Brachyury   NRSF form 1   NRSF form 2   GATA-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC39A4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC39A4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC39A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

SLC39A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145637:  view genomic region     (about GC identifiers)

Start:
145,635,126 bp from pter      End:
145,642,279 bp from pter
Size:
7,154 bases      Orientation:
minus strand

1 alternative location:
Chr8-,NW_003315924 181,673-186,148     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5 (See protein sequence)
Recommended Name: Zinc transporter ZIP4 precursor  
Size: 647 amino acids; 68392 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane
protein. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the
plasma membrane in response to zinc availability
Sequence caution: Sequence=BAA91091.1; Type=Frameshift; Positions=573, 598, 618;
Secondary accessions: Q7L5S5 Q9H6T8 Q9NXC4
Alternative splicing: 2 isoforms:  Q6P5W5-1   Q6P5W5-2   

Explore the universe of human proteins at neXtProt for SLC39A4: NX_Q6P5W5

Explore proteomics data for SLC39A4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P5W5

  • SLC39A4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC39A4 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001267486.1  NP_060237.2  NP_570901.2  

    ENSEMBL proteins: 
     ENSP00000276833   ENSP00000301305   ENSP00000434512  
    Reactome Protein details: Q6P5W5
    Human Recombinant Protein Products for SLC39A4: 
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    Cloud-Clone Corp. Proteins for SLC39A4 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome ----
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IDA14612438

    SLC39A4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 4 
    SLC39 family of metal ion transporters

    1 InterPro protein domain:
     IPR003689 ZIP

    Graphical View of Domain Structure for InterPro Entry Q6P5W5

    ProtoNet protein and cluster: Q6P5W5

    1 Blocks protein domain: IPB003689 Zinc transporter ZIP

    UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5
    Similarity: Belongs to the ZIP transporter (TC 2.A.5) family


    SLC39A4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S39A4_HUMAN, Q6P5W5
    Function: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to
    zinc availability (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005385zinc ion transmembrane transporter activity IEA--
    GO:0046873metal ion transmembrane transporter activity ----
         
    SLC39A4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC39A4:
     Decreased viability with pacli 

         15 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc39a4):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  liver/biliary system  mortality/aging 
     muscle  nervous system  other  skeleton  vision/eye 

    SLC39A4 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC39A4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Zinc transporters
    Zinc transporters0.68
    Zinc influx into cells by the SLC39 gene family0.59
    Metal ion SLC transporters0.68
    2SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    3Senescence and Autophagy
    Senescence and Autophagy
    4Mineral absorption
    Mineral absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SLC39A4
        Senescence and Autophagy

    5/6        Reactome Pathways for SLC39A4 (see all 6)
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Metal ion SLC transporters
    Zinc transporters


    1         Kegg Pathway  (Kegg details for SLC39A4):
        Mineral absorption


    SLC39A4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC39A4

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006829zinc ion transport ----
    GO:0006882cellular zinc ion homeostasis IEA--
    GO:0030001metal ion transport ----
    GO:0034224cellular response to zinc ion starvation IEA--
    GO:0055085transmembrane transport TAS--

    SLC39A4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC39A4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC39A4 (S39A4)

    1 Novoseek inferred chemical compound relationship for SLC39A4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 69.2 62 15358787 (8), 12801924 (6), 17483098 (5), 17202136 (4) (see all 11)

    Search CenterWatch for drugs/clinical trials and news about SLC39A4 / S39A4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC39A4 gene (3 alternative transcripts): 
    NM_001280557.1  NM_017767.2  NM_130849.3  

    Unigene Cluster for SLC39A4:

    Solute carrier family 39 (zinc transporter), member 4
    Hs.521934  [show with all ESTs]
    Unigene Representative Sequence: AK056900
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527148 ENST00000529462(uc003zcm.1) ENST00000530807 ENST00000532718(uc003zcn.3)
    ENST00000276833(uc003zcp.3) ENST00000301305(uc003zco.3 uc003zcq.3)
    ENST00000531013 ENST00000531789 ENST00000526658
    miRNA
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    Additional mRNA sequence: 

    AK000334.1 AK000489.1 AK000695.1 AK025537.1 AK056900.1 AK290563.1 BC001688.2 BC062625.1 

    8 DOTS entries:

    DT.444715  DT.100779040  DT.95161761  DT.97861814  DT.95254719  DT.97861813  DT.95161762  DT.121469661 

    24/105 AceView cDNA sequences (see all 105):

    BQ677952 BM810871 BG235988 BQ433248 AI634653 AK000489 BX107695 CR600637 
    BM687088 BC001688 AW015314 BQ671081 BM423917 BF739887 AA424487 BM914864 
    BM796349 BU163061 BU181201 AA946921 BQ680356 BU602174 BM837553 AK056900 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A4 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
    SP1:              -                                                     -                                                   
    SP2:                                                                    -                                                   
    SP3:                                                                    -                                                   
    SP4:                                                                                                              -         
    SP5:              -     -                                                                                                   


    ECgene alternative splicing isoforms for SLC39A4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC39A4 expression in normal human tissues (normalized intensities)      SLC39A4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCGGCGA
    SLC39A4 Expression
    About this image


    SLC39A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Intestine (Gastrointestinal Tract)
             small intestine   
     
     Hair (Integumentary System)
             mouse/organ system/integumental system   
     
     Umbilical Cord (Extraembryonic Tissues)
             cord blood   
     
     Tooth
             mouse/organ system/integumental system   

    See SLC39A4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC39A4

    SOURCE GeneReport for Unigene cluster: Hs.521934

    UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5
    Tissue specificity: Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC39A4 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc39a41 , 5 solute carrier family 39 (zinc transporter), member more1, 5 76.35(n)1
    73.63(a)1
      15 (36.16 cM)5
    720271  NM_028064.21  NP_082340.11 
     766123855 
    lizard
    (Anolis carolinensis)
    Reptilia SLC39A46
    --
    --
    72(a)
    29(a)
    1 ↔ many
    1 ↔ many
    GL343636.1(1418-3338)
    GL343995.1(65672-95631)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100066
    --
    23(a)
    possible ortholog
    3L(14985389-14990917)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1416
    Protein TAG-141
    27(a)
    1 ↔ 1
    IV(17364880-17366491)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YKE46
    Zinc transporter; localizes to the ER; null mutant...
    20(a)
    1 → many
    IX(309386-310426)


    ENSEMBL Gene Tree for SLC39A4 (if available)
    TreeFam Gene Tree for SLC39A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC39A4 gene
    SLC39A102  SLC39A52  SLC39A82  SLC39A62  SLC39A122  SLC39A142  SLC39A72  SLC39A132  
    3 SIMAP similar genes for SLC39A4 using alignment to 3 protein entries:     S39A4_HUMAN (see all proteins):
    SLC39A12    SLC39A8    SLC39A14

    SLC39A4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/360 SNPs in SLC39A4 are shown (see all 360)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0236384
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236382 L P mis40--------
    VAR_0236394
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236392 G R mis40--------
    VAR_0236424
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236422 G R mis40--------
    VAR_0236364
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236362 G D mis40--------
    VAR_0236324
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236322 P L mis40--------
    VAR_0236304
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236302 N K mis40--------
    VAR_0236344
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236342 Q H mis40--------
    VAR_0236294
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236292 R C mis40--------
    VAR_0236414
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236412 G R mis40--------
    rs1214342871,2
    Cpathogenic1145913650(-) CTTGCC/TGAGCC 4 P L mis10--------

    HapMap Linkage Disequilibrium report for SLC39A4 (145635126 - 145642279 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for SLC39A4 (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738065CNV Deletion23290073
    dgv907n27CNV Loss19166990
    dgv7966n71CNV Loss21882294
    nsv891841CNV Loss21882294
    nsv891846CNV Loss21882294
    nsv891817CNV Loss21882294
    dgv7967n71CNV Loss21882294
    nsv891807CNV Loss21882294
    nsv891873CNV Loss21882294
    dgv7970n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): SLC39A4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC39A4
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC39A4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607059   
    OMIM disorders: 201100  
    UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5
  • Acrodermatitis enteropathica, zinc-deficiency type (AEZ) [MIM:201100]: A rare autosomal recessive disease
    caused by the inability to absorb sufficient zinc. The clinical features are growth retardation, immune-system
    dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 12 diseases for SLC39A4:    About MalaCards
    enteropathica    acrodermatitis    acrodermatitis enteropathica    mental disorders
    autosomal recessive disease    diarrhea    alopecia    pancreatic cancer
    dermatitis    pancreatitis    endotheliitis    retinitis

    2 diseases from the University of Copenhagen DISEASES database for SLC39A4:
    Acrodermatitis enteropathica     Acrodermatitis

    SLC39A4 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SLC39A4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acrodermatitis enteropathica 97.9 25 12801924 (3), 12787121 (3), 17483098 (2), 20300938 (2) (see all 13)
    zinc deficiency 85.3 7 15358787 (3), 17483098 (2), 12801924 (1)
    genetic disorder 61.2 5 12801924 (1), 17483098 (1), 14709598 (1), 15358787 (1)

    Genetic Association Database (GAD): SLC39A4
    Human Genome Epidemiology (HuGE) Navigator: SLC39A4 (2 documents)

    Export disorders for SLC39A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC39A4 gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with SLC39A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice. (PubMed id 12801924)1, 3, 9 Dufner-Beattie J....Andrews G.K. (2003)
    2. Acrodermatitis enteropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter. (PubMed id 14709598)1, 3, 9 Wang F....Eide D.J. (2004)
    3. Novel SLC39A4 mutations in acrodermatitis enteropathica. (PubMed id 12787121)1, 2, 9 Nakano A.... Hanada K. (2003)
    4. Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane. (PubMed id 14612438)1, 2, 9 Kim B.-E....Petris M.J. (2004)
    5. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PubMed id 12659941)1, 3 Taylor K.M. and Nicholson R.I. (2003)
    9. Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. (PubMed id 12068297)1, 2 Kuery S....Moisan J.-P. (2002)
    10. A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. (PubMed id 12032886)1, 2 Wang K.... Gitschier J. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55630 HGNC: 17129 AceView: SLC39A4 Ensembl:ENSG00000147804 euGenes: HUgn55630
    ECgene: SLC39A4 Kegg: 55630 H-InvDB: SLC39A4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC39A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC39A4 gene:
    Search GeneIP for patents involving SLC39A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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