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SLC39A4 Gene

protein-coding   GIFtS: 60
GCID: GC08M145637

Solute Carrier Family 39 (Zinc Transporter), Member 4

(Previous names: acrodermatitis enteropathica, zinc-deficiency type)
(Previous symbol: AEZ)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 41 2     AWMS22
ZIP42 3 5     Zinc Transporter ZIP42
AEZ1 2     ZIP-43
Zrt- And Irt-Like Protein 42 3     Solute Carrier Family 39 Member 43
Acrodermatitis Enteropathica, Zinc-Deficiency Type1     

External Ids:    HGNC: 171291   Entrez Gene: 556302   Ensembl: ENSG000001478047   OMIM: 6070595   UniProtKB: Q6P5W53   

Export aliases for SLC39A4 gene to outside databases

Previous GC identifers: GC08M143241 GC08M145675 GC08M145239 GC08M145642 GC08M145608 GC08M140751


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC39A4 Gene:
This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein
localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in
acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jul 2013)

GeneCards Summary for SLC39A4 Gene:
SLC39A4 (solute carrier family 39 (zinc transporter), member 4) is a protein-coding gene. Diseases associated with SLC39A4 include acrodermatitis, and enteropathica. GO annotations related to this gene include zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A10.

UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5
Function: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to
zinc availability (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC39A4 gene promoter:
         Brachyury   NRSF form 1   NRSF form 2   GATA-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC39A4 promoter sequence
   Search Chromatin IP Primers for SLC39A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC39A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

SLC39A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145637:  view genomic region     (about GC identifiers)

Start:
145,635,126 bp from pter      End:
145,642,279 bp from pter
Size:
7,154 bases      Orientation:
minus strand

1 alternative location:
Chr8-,NW_003315924 181,673-186,148     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5 (See protein sequence)
Recommended Name: Zinc transporter ZIP4 precursor  
Size: 647 amino acids; 68392 Da
Sequence caution: Sequence=BAA91091.1; Type=Frameshift; Positions=573, 598, 618;
Secondary accessions: Q7L5S5 Q9H6T8 Q9NXC4
Alternative splicing: 2 isoforms:  Q6P5W5-1   Q6P5W5-2   

Explore the universe of human proteins at neXtProt for SLC39A4: NX_Q6P5W5

Explore proteomics data for SLC39A4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn261
  • Modification sites at PhosphoSitePlus

  • See SLC39A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001267486.1  NP_060237.2  NP_570901.2  

    ENSEMBL proteins: 
     ENSP00000276833   ENSP00000301305   ENSP00000434512  
    Reactome Protein details: Q6P5W5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 4
    SLC39 family of metal ion transporters

    1 InterPro protein domain:
     IPR003689 ZIP

    Graphical View of Domain Structure for InterPro Entry Q6P5W5

    ProtoNet protein and cluster: Q6P5W5

    1 Blocks protein domain: IPB003689 Zinc transporter ZIP

    UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5
    Similarity: Belongs to the ZIP transporter (TC 2.A.5) family


    SLC39A4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S39A4_HUMAN, Q6P5W5
    Function: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to
    zinc availability (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005385zinc ion transmembrane transporter activity IEA--
    GO:0046873metal ion transmembrane transporter activity ----
         
    SLC39A4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC39A4:
     Decreased viability with pacli 

         15 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc39a4):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  liver/biliary system  mortality/aging 
     muscle  nervous system  other  skeleton  vision/eye 

    SLC39A4 for phenotypes           About GeneDecksing

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S39A4_HUMAN, Q6P5W5: Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane
    protein. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the
    plasma membrane in response to zinc availability
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome ----
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IDA14612438

    SLC39A4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC39A4 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    2Metal ion SLC transporters
    Metal ion SLC transporters
    Zinc influx into cells by the SLC39 gene family0.00
    Zinc transporters0.00
    3Senescence and Autophagy
    Senescence and Autophagy
    4Mineral absorption
    Mineral absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SLC39A4
        Senescence and Autophagy

    1 Reactome Pathway for SLC39A4
        Zinc influx into cells by the SLC39 gene family


    1 Kegg Pathway  (Kegg details for SLC39A4):
        Mineral absorption


    SLC39A4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC39A4
    Interactions:

        Search GeneGlobe Interaction Network for SLC39A4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC39A4 (ENSP000003013054) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC30A5ENSP000003798364STRING: ENSP00000379836
    SLC30A6ENSP000002825874STRING: ENSP00000282587
    SLC30A7ENSP000003502784STRING: ENSP00000350278
    SLC30A1ENSP000003559684STRING: ENSP00000355968
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006829zinc ion transport ----
    GO:0006882cellular zinc ion homeostasis IEA--
    GO:0030001metal ion transport ----
    GO:0034224cellular response to zinc ion starvation IEA--
    GO:0055085transmembrane transport TAS--

    SLC39A4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC39A4 (S39A4)

    1 Novoseek inferred chemical compound relationship for SLC39A4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 69.2 62 15358787 (8), 12801924 (6), 17483098 (5), 17202136 (4) (see all 11)



    SLC39A4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC39A4 gene (3 alternative transcripts): 
    NM_001280557.1  NM_017767.2  NM_130849.3  

    Unigene Cluster for SLC39A4:

    Solute carrier family 39 (zinc transporter), member 4
    Hs.521934  [show with all ESTs]
    Unigene Representative Sequence: AK056900
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527148 ENST00000529462(uc003zcm.1) ENST00000530807 ENST00000532718(uc003zcn.3)
    ENST00000276833(uc003zcp.3) ENST00000301305(uc003zco.3 uc003zcq.3)
    ENST00000531013 ENST00000531789 ENST00000526658
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    Additional mRNA sequence: 

    AK000334.1 AK000489.1 AK000695.1 AK025537.1 AK056900.1 AK290563.1 BC001688.2 BC062625.1 

    8 DOTS entries:

    DT.444715  DT.100779040  DT.95161761  DT.97861814  DT.95254719  DT.97861813  DT.95161762  DT.121469661 

    Selected AceView cDNA sequences (see all 105):

    BQ671081 AA946921 BF739887 BG235988 BQ680356 BC001688 AA424487 BQ677952 
    BX107695 BU181201 BM423917 BM796349 AW015314 BM914864 BM687088 BU163061 
    AI634653 BQ433248 BM810871 AK000489 CR600637 BU190929 BM009092 BU168105 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A4 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
    SP1:              -                                                     -                                                   
    SP2:                                                                    -                                                   
    SP3:                                                                    -                                                   
    SP4:                                                                                                              -         
    SP5:              -     -                                                                                                   


    ECgene alternative splicing isoforms for SLC39A4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC39A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCGGCGA
    SLC39A4 Expression
    About this image


    SLC39A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Brain (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus
     
     Eye (Sensory Organs)
             Retina
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Lung (Respiratory System)
    SLC39A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC39A4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.521934

    UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5
    Tissue specificity: Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC39A4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc39a41 , 5 solute carrier family 39 (zinc transporter), member more1, 5 76.48(n)1
    74.11(a)1
      15 (36.16 cM)5
    720271  NM_028064.21  NP_082340.11 
     766123855 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100066
    --
    24(a)
    1 ↔ 1
    3L(14985389-14990917)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1416
    Protein TAG-141 (tag-141) mRNA, complete cds
    26(a)
    1 ↔ 1
    IV(17364880-17366491) WBGene00006487


    ENSEMBL Gene Tree for SLC39A4 (if available)
    TreeFam Gene Tree for SLC39A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC39A4 gene
    SLC39A102  SLC39A52  SLC39A82  SLC39A62  SLC39A122  SLC39A142  SLC39A132  SLC39A72  
    3 SIMAP similar genes for SLC39A4 using alignment to 3 protein entries:     S39A4_HUMAN (see all proteins):
    SLC39A12    SLC39A8    SLC39A14

    SLC39A4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC39A4 (see all 360)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0236384
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236382 L P mis40--------
    VAR_0236394
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236392 G R mis40--------
    VAR_0236424
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236422 G R mis40--------
    VAR_0236364
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236362 G D mis40--------
    VAR_0236324
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236322 P L mis40--------
    VAR_0236304
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236302 N K mis40--------
    VAR_0236344
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236342 Q H mis40--------
    VAR_0236294
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236292 R C mis40--------
    VAR_0236414
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)4--see VAR_0236412 G R mis40--------
    rs1214342871,2
    Cpathogenic1145913650(-) CTTGCC/TGAGCC 4 P L mis10--------

    HapMap Linkage Disequilibrium report for SLC39A4 (145635126 - 145642279 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC39A4 (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738065CNV Deletion23290073
    dgv907n27CNV Loss19166990
    dgv7966n71CNV Loss21882294
    nsv891841CNV Loss21882294
    nsv891846CNV Loss21882294
    nsv891817CNV Loss21882294
    dgv7967n71CNV Loss21882294
    nsv891807CNV Loss21882294
    nsv891873CNV Loss21882294
    dgv7970n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): SLC39A4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC39A4
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC39A4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607059   
    OMIM disorders: 201100  
    UniProtKB/Swiss-Prot: S39A4_HUMAN, Q6P5W5
  • Acrodermatitis enteropathica, zinc-deficiency type (AEZ) [MIM:201100]: A rare autosomal recessive disease
    caused by the inability to absorb sufficient zinc. The clinical features are growth retardation, immune-system
    dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 16 diseases for SLC39A4:    
    About MalaCards
    acrodermatitis    enteropathica    acrodermatitis enteropathica    autosomal recessive disease
    diarrhea    alopecia    pancreatic cancer    choroiditis
    dermatitis    retinitis    pancreatitis    multiple myeloma
    endotheliitis    myeloma    hepatocellular carcinoma    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for SLC39A4:
    Acrodermatitis enteropathica     Acrodermatitis

    SLC39A4 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SLC39A4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acrodermatitis enteropathica 97.9 25 12801924 (3), 12787121 (3), 17483098 (2), 20300938 (2) (see all 13)
    zinc deficiency 85.3 7 15358787 (3), 17483098 (2), 12801924 (1)
    genetic disorder 61.2 5 12801924 (1), 17483098 (1), 14709598 (1), 15358787 (1)

    Genetic Association Database (GAD): SLC39A4
    Human Genome Epidemiology (HuGE) Navigator: SLC39A4 (2 documents)

    Export disorders for SLC39A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC39A4 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with SLC39A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice. (PubMed id 12801924)1, 3, 9 Dufner-Beattie J....Andrews G.K. (J. Biol. Chem. 2003)
    2. Acrodermatitis enteropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter. (PubMed id 14709598)1, 3, 9 Wang F....Eide D.J. (Hum. Mol. Genet. 2004)
    3. Novel SLC39A4 mutations in acrodermatitis enteropathica. (PubMed id 12787121)1, 2, 9 Nakano A.... Hanada K. (J. Invest. Dermatol. 2003)
    4. Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane. (PubMed id 14612438)1, 2, 9 Kim B.-E....Petris M.J. (J. Biol. Chem. 2004)
    5. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PubMed id 12659941)1, 3 Taylor K.M. and Nicholson R.I. (Biochim. Biophys. Acta 2003)
    9. Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. (PubMed id 12068297)1, 2 Kuery S....Moisan J.-P. (Nat. Genet. 2002)
    10. A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. (PubMed id 12032886)1, 2 Wang K.... Gitschier J. (Am. J. Hum. Genet. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55630 HGNC: 17129 AceView: SLC39A4 Ensembl:ENSG00000147804 euGenes: HUgn55630
    ECgene: SLC39A4 Kegg: 55630 H-InvDB: SLC39A4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC39A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC39A4 gene:
    Search GeneIP for patents involving SLC39A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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