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Aliases for SLC39A3 Gene

Aliases for SLC39A3 Gene

  • Solute Carrier Family 39 Member 3 2 3 4 5
  • Solute Carrier Family 39 (Zinc Transporter), Member 3 2 3
  • Zrt- And Irt-Like Protein 3 3 4
  • ZIP-3 3 4
  • ZIP3 3 4
  • Zinc Transporter ZIP3 3

External Ids for SLC39A3 Gene

Previous GeneCards Identifiers for SLC39A3 Gene

  • GC19M002795
  • GC19M002672
  • GC19M002683
  • GC19M002502

Summaries for SLC39A3 Gene

GeneCards Summary for SLC39A3 Gene

SLC39A3 (Solute Carrier Family 39 Member 3) is a Protein Coding gene. Among its related pathways are Metal ion SLC transporters and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include metal ion transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A1.

UniProtKB/Swiss-Prot for SLC39A3 Gene

  • Acts as a zinc-influx transporter.

Gene Wiki entry for SLC39A3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A3 Gene

Genomics for SLC39A3 Gene

Regulatory Elements for SLC39A3 Gene

Enhancers for SLC39A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F002726 0.5 Ensembl 14.4 +12.8 12809 1.9 BCOR ZNF263 HLF ZMYM3 CEBPB ZNF623 ZNF7 SCRT2 MAFK SP7 DIRAS1 SLC39A3 ZNF554 ENSG00000261342 GC19P002723
GH19F002737 0.2 Ensembl 13.9 +2.8 2752 0.8 BCOR CBX1 SCRT2 ZMYM3 KDM1A SLC39A3 GC19P002738 PIR51189
GH19F002738 0.2 ENCODE 12.7 +0.6 625 2.4 PKNOX1 ARNT MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SF3A2 THOP1 ZNF554 SLC39A3 DIRAS1 GNA11 C19orf35 MKNK2 ENSG00000267001 GC19P002738
GH19F002693 1.2 FANTOM5 Ensembl ENCODE 12.3 +45.0 44985 3.3 SRF ZNF146 ZNF266 ZNF514 NR2F2 ZFHX2 ZNF366 ZNF512 EED PRDM1 DIRAS1 CACTIN GNG7 ZNF77 SLC39A3 CACTIN-AS1 ZNF556 LINGO3 ENSG00000276097 PIR43863
GH19F002615 1.6 FANTOM5 Ensembl ENCODE 12.3 +112.5 112527 24.4 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 GADD45B SF3A2 GNG7 DIRAS1 LOC100288123 CACTIN-AS1 RNU6-993P SLC39A3 C19orf35 LOC101928631
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC39A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC39A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000341894 352 1601 MLX CREB3L1 ZFP64 DMAP1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MEF2D

Genomic Location for SLC39A3 Gene

Chromosome:
19
Start:
2,732,204 bp from pter
End:
2,740,152 bp from pter
Size:
7,949 bases
Orientation:
Minus strand

Genomic View for SLC39A3 Gene

Genes around SLC39A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A3 Gene

Proteins for SLC39A3 Gene

  • Protein details for SLC39A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRY0-S39A3_HUMAN
    Recommended name:
    Zinc transporter ZIP3
    Protein Accession:
    Q9BRY0
    Secondary Accessions:
    • B3KMJ3
    • Q8WUG1

    Protein attributes for SLC39A3 Gene

    Size:
    314 amino acids
    Molecular mass:
    33601 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC39A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A3 Gene

Post-translational modifications for SLC39A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC39A3 Gene

No data available for DME Specific Peptides for SLC39A3 Gene

Domains & Families for SLC39A3 Gene

Gene Families for SLC39A3 Gene

Protein Domains for SLC39A3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC39A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRY0

UniProtKB/Swiss-Prot:

S39A3_HUMAN :
  • Belongs to the ZIP transporter (TC 2.A.5) family.
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A3: view

Function for SLC39A3 Gene

Molecular function for SLC39A3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a zinc-influx transporter.

Gene Ontology (GO) - Molecular Function for SLC39A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity TAS --
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A3: view
genes like me logo Genes that share phenotypes with SLC39A3: view

Animal Models for SLC39A3 Gene

MGI Knock Outs for SLC39A3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC39A3

miRNA for SLC39A3 Gene

miRTarBase miRNAs that target SLC39A3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC39A3 Gene

Localization for SLC39A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC39A3 Gene COMPARTMENTS Subcellular localization image for SLC39A3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC39A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC39A3: view

Pathways & Interactions for SLC39A3 Gene

genes like me logo Genes that share pathways with SLC39A3: view

Interacting Proteins for SLC39A3 Gene

Gene Ontology (GO) - Biological Process for SLC39A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006829 zinc II ion transport IEA --
genes like me logo Genes that share ontologies with SLC39A3: view

No data available for SIGNOR curated interactions for SLC39A3 Gene

Drugs & Compounds for SLC39A3 Gene

(1) Drugs for SLC39A3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLC39A3: view

Transcripts for SLC39A3 Gene

Unigene Clusters for SLC39A3 Gene

Solute carrier family 39 (zinc transporter), member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A3 Gene

No ASD Table

Relevant External Links for SLC39A3 Gene

GeneLoc Exon Structure for
SLC39A3
ECgene alternative splicing isoforms for
SLC39A3

Expression for SLC39A3 Gene

mRNA expression in normal human tissues for SLC39A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC39A3 Gene

This gene is overexpressed in Testis (x5.7).

Protein differential expression in normal tissues from HIPED for SLC39A3 Gene

This gene is overexpressed in Ovary (47.7), Testis (14.0), and Platelet (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC39A3 Gene



Protein tissue co-expression partners for SLC39A3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC39A3 Gene:

SLC39A3

SOURCE GeneReport for Unigene cluster for SLC39A3 Gene:

Hs.515046
genes like me logo Genes that share expression patterns with SLC39A3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC39A3 Gene

Orthologs for SLC39A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC39A3 34 35
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia SLC39A3 34 35
  • 89.38 (n)
cow
(Bos Taurus)
Mammalia SLC39A3 34 35
  • 88.85 (n)
mouse
(Mus musculus)
Mammalia Slc39a3 34 16 35
  • 81.74 (n)
rat
(Rattus norvegicus)
Mammalia Slc39a3 34
  • 81.74 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC39A3 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC39A3 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC39A3 34 35
  • 76.78 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a3 34
  • 62.83 (n)
Str.17341 34
fruit fly
(Drosophila melanogaster)
Insecta Zip3 34 35
  • 49.83 (n)
ZIP1 35
  • 26 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011178 34
  • 46.38 (n)
worm
(Caenorhabditis elegans)
Secernentea C18A3.2 35
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
Species where no ortholog for SLC39A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC39A3 Gene

ENSEMBL:
Gene Tree for SLC39A3 (if available)
TreeFam:
Gene Tree for SLC39A3 (if available)

Paralogs for SLC39A3 Gene

Paralogs for SLC39A3 Gene

(2) SIMAP similar genes for SLC39A3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC39A3: view

Variants for SLC39A3 Gene

Sequence variations from dbSNP and Humsavar for SLC39A3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10405932 -- 2,737,476(+) AATGG(C/T)GCAAT intron-variant
rs10415622 -- 2,739,698(+) TGGAT(A/G)CCTCA intron-variant
rs10424305 -- 2,737,553(+) GACAC(A/G)CGCCA intron-variant
rs11084955 -- 2,738,645(+) tggct(C/T)acacc intron-variant
rs111311797 -- 2,738,482(+) TCTGT(C/G)CCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A3 Gene

Variant ID Type Subtype PubMed ID
esv3643437 CNV gain 21293372
nsv509714 CNV insertion 20534489
nsv828397 CNV gain 20364138

Variation tolerance for SLC39A3 Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC39A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC39A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A3 Gene

Disorders for SLC39A3 Gene

Relevant External Links for SLC39A3

Genetic Association Database (GAD)
SLC39A3
Human Genome Epidemiology (HuGE) Navigator
SLC39A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC39A3

No disorders were found for SLC39A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A3 Gene

Publications for SLC39A3 Gene

  1. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PMID: 19308021) Ollila H.M. … Paunio T. (Mol. Psychiatry 2009) 3 46 64
  2. hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands. (PMID: 17550612) Desouki M.M. … Costello L.C. (Mol. Cancer 2007) 3 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. (PMID: 14525987) Dufner-Beattie J. … Andrews G.K. (J. Biol. Chem. 2003) 3 22 64
  5. Functional expression of the human hZIP2 zinc transporter. (PMID: 10681536) Gaither L.A. … Eide D.J. (J. Biol. Chem. 2000) 2 3 64

Products for SLC39A3 Gene

Sources for SLC39A3 Gene

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