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Aliases for SLC39A14 Gene

Aliases for SLC39A14 Gene

  • Solute Carrier Family 39 Member 14 2 3 4
  • Solute Carrier Family 39 (Zinc Transporter), Member 14 2 3 5
  • Solute Carrier Family 39 (Metal Ion Transporter), Member 14 2 3
  • LIV-1 Subfamily Of ZIP Zinc Transporter 4 3 4
  • Zrt- And Irt-Like Protein 14 3 4
  • LZT-Hs4 3 4
  • ZIP-14 3 4
  • ZIP14 3 4
  • Zrt-, Irt-Like Protein 14 3
  • KIAA0062 4
  • NET34 3
  • Cig19 3

External Ids for SLC39A14 Gene

Previous GeneCards Identifiers for SLC39A14 Gene

  • GC08P022246
  • GC08P020766
  • GC08P022224

Summaries for SLC39A14 Gene

Entrez Gene Summary for SLC39A14 Gene

  • Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC39A14 Gene

SLC39A14 (Solute Carrier Family 39 Member 14) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. GO annotations related to this gene include ferrous iron transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A12.

UniProtKB/Swiss-Prot for SLC39A14 Gene

  • May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A14 Gene

Genomics for SLC39A14 Gene

Regulatory Elements for SLC39A14 Gene

Enhancers for SLC39A14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC39A14 on UCSC Golden Path with GeneCards custom track

Promoters for SLC39A14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC39A14 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC39A14 Gene

22,367,249 bp from pter
22,434,129 bp from pter
66,881 bases
Plus strand

Genomic View for SLC39A14 Gene

Genes around SLC39A14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A14 Gene

Proteins for SLC39A14 Gene

  • Protein details for SLC39A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc transporter ZIP14
    Protein Accession:
    Secondary Accessions:
    • A6NH98
    • B4DIW3
    • B6EU88
    • D3DSR4
    • Q6ZME8
    • Q96BB3

    Protein attributes for SLC39A14 Gene

    492 amino acids
    Molecular mass:
    54212 Da
    Quaternary structure:
    • Homotrimer.
    • Sequence=BAA06685.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC39A14 Gene


neXtProt entry for SLC39A14 Gene

Proteomics data for SLC39A14 Gene at MOPED

Post-translational modifications for SLC39A14 Gene

  • Glycosylation at Asn 77 and Asn 102
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC39A14 Gene

Domains & Families for SLC39A14 Gene

Gene Families for SLC39A14 Gene

Protein Domains for SLC39A14 Gene


Suggested Antigen Peptide Sequences for SLC39A14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZIP transporter (TC 2.A.5) family.
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A14: view

Function for SLC39A14 Gene

Molecular function for SLC39A14 Gene

UniProtKB/Swiss-Prot Function:
May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake.
genes like me logo Genes that share phenotypes with SLC39A14: view

Animal Models for SLC39A14 Gene

MGI Knock Outs for SLC39A14:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC39A14

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC39A14 Gene

Localization for SLC39A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A14 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, lamellipodium. Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae.

Subcellular locations from

Jensen Localization Image for SLC39A14 Gene COMPARTMENTS Subcellular localization image for SLC39A14 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 5
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SLC39A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC39A14: view

Pathways & Interactions for SLC39A14 Gene

genes like me logo Genes that share pathways with SLC39A14: view

Gene Ontology (GO) - Biological Process for SLC39A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015684 ferrous iron transport IEA --
GO:0055085 transmembrane transport IEA --
GO:0071577 zinc II ion transmembrane transport IMP 15642354
GO:0071578 zinc II ion transmembrane import IDA 15642354
genes like me logo Genes that share ontologies with SLC39A14: view

No data available for SIGNOR curated interactions for SLC39A14 Gene

Drugs & Compounds for SLC39A14 Gene

(1) Drugs for SLC39A14 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nortriptyline Approved Pharma Antagonist, Pore Blocker 46

(1) Additional Compounds for SLC39A14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
genes like me logo Genes that share compounds with SLC39A14: view

Transcripts for SLC39A14 Gene

Unigene Clusters for SLC39A14 Gene

Solute carrier family 39 (zinc transporter), member 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A14 Gene

No ASD Table

Relevant External Links for SLC39A14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC39A14 Gene

mRNA expression in normal human tissues for SLC39A14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC39A14 Gene

This gene is overexpressed in Liver (x13.0) and Pancreas (x5.4).

Protein differential expression in normal tissues from HIPED for SLC39A14 Gene

This gene is overexpressed in Liver (17.6), Bone (17.6), and Fetal Liver (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC39A14 Gene

SOURCE GeneReport for Unigene cluster for SLC39A14 Gene Hs.491232

mRNA Expression by UniProt/SwissProt for SLC39A14 Gene

Tissue specificity: Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with SLC39A14: view

Primer Products

No data available for Protein tissue co-expression partners for SLC39A14 Gene

Orthologs for SLC39A14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC39A14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC39A14 35
  • 86.48 (n)
  • 89.55 (a)
SLC39A14 36
  • 85 (a)
(Canis familiaris)
Mammalia SLC39A14 35
  • 89.89 (n)
  • 90.37 (a)
SLC39A14 36
  • 90 (a)
(Mus musculus)
Mammalia Slc39a14 35
  • 84.98 (n)
  • 87.04 (a)
Slc39a14 16
Slc39a14 36
  • 83 (a)
(Pan troglodytes)
Mammalia SLC39A14 35
  • 99.11 (n)
  • 99.18 (a)
SLC39A14 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc39a14 35
  • 80.99 (n)
  • 83.47 (a)
(Monodelphis domestica)
Mammalia SLC39A14 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
-- 36
  • 80 (a)
(Gallus gallus)
Aves SLC39A14 35
  • 78.96 (n)
  • 83.22 (a)
SLC39A14 36
  • 77 (a)
(Anolis carolinensis)
Reptilia SLC39A14 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a14 35
  • 70.33 (n)
  • 73.46 (a)
(Danio rerio)
Actinopterygii LOC799782 35
  • 63.93 (n)
  • 62.75 (a)
SLC39A14 36
  • 67 (a)
(Caenorhabditis elegans)
Secernentea Y55F3BL.2 35
  • 49.33 (n)
  • 40.25 (a)
tag-140 36
  • 19 (a)
Y55F3BL.2 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKE4 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for SLC39A14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A14 Gene

Gene Tree for SLC39A14 (if available)
Gene Tree for SLC39A14 (if available)

Paralogs for SLC39A14 Gene

(3) SIMAP similar genes for SLC39A14 Gene using alignment to 8 proteins: Pseudogenes for SLC39A14 Gene

genes like me logo Genes that share paralogs with SLC39A14: view

Variants for SLC39A14 Gene

Sequence variations from dbSNP and Humsavar for SLC39A14 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs896378 - 22,404,808(+) ATCCC(C/T)GGGTG reference, missense
rs2122877 -- 22,424,903(-) TACAG(A/G)GGCAC intron-variant
rs2280521 -- 22,414,482(+) CAAGA(G/T)AAATC intron-variant
rs2280522 -- 22,414,713(+) AAGAG(A/G)TAAGA intron-variant
rs2293144 -- 22,404,905(+) GCCCT(A/G)CTCAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SLC39A14 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
nsv518646 CNV Gain 19592680
nsv831266 CNV Loss 17160897
essv1932 CNV CNV 17122850
nsv6116 CNV Insertion 18451855
nsv890671 CNV Loss 21882294
esv1010019 CNV Deletion 20482838
esv2736746 CNV Deletion 23290073
nsv398059 CNV Loss 16902084
esv2736747 CNV Deletion 23290073
dgv451n21 CNV Loss 19592680
nsv8321 CNV Gain 18304495

Variation tolerance for SLC39A14 Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.08; 92.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC39A14 Gene

Disorders for SLC39A14 Gene

Relevant External Links for SLC39A14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC39A14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A14 Gene

Publications for SLC39A14 Gene

  1. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PMID: 12659941) Taylor K.M. … Nicholson R.I. (Biochim. Biophys. Acta 2003) 2 3 4 67
  2. The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells. (PMID: 18524764) Gao J. … Enns C.A. (J. Biol. Chem. 2008) 3 23
  3. Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14. (PMID: 15642354) Taylor K.M. … Nicholson R.I. (FEBS Lett. 2005) 3 23
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for SLC39A14 Gene

Sources for SLC39A14 Gene