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Aliases for SLC39A14 Gene

Aliases for SLC39A14 Gene

  • Solute Carrier Family 39 (Zinc Transporter), Member 14 2 3
  • Solute Carrier Family 39 (Metal Ion Transporter), Member 14 2 3
  • LIV-1 Subfamily Of ZIP Zinc Transporter 4 3 4
  • Solute Carrier Family 39 Member 14 3 4
  • Zrt- And Irt-Like Protein 14 3 4
  • LZT-Hs4 3 4
  • ZIP-14 3 4
  • ZIP14 3 4
  • Zrt-, Irt-Like Protein 14 3
  • Zinc Transporter ZIP14 3
  • KIAA0062 4
  • NET34 3
  • Cig19 3

External Ids for SLC39A14 Gene

Summaries for SLC39A14 Gene

Entrez Gene Summary for SLC39A14 Gene

  • Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC39A14 Gene

SLC39A14 (Solute Carrier Family 39 (Zinc Transporter), Member 14) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include zinc ion transmembrane transporter activity and ferrous iron transmembrane transporter activity. An important paralog of this gene is SLC39A12.

UniProtKB/Swiss-Prot for SLC39A14 Gene

  • May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A14 Gene

Genomics for SLC39A14 Gene

Genomic Location for SLC39A14 Gene

Start:
22,367,249 bp from pter
End:
22,434,129 bp from pter
Size:
66,881 bases
Orientation:
Plus strand

Genomic View for SLC39A14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC39A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A14 Gene

Regulatory Elements for SLC39A14 Gene

Proteins for SLC39A14 Gene

  • Protein details for SLC39A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15043-S39AE_HUMAN
    Recommended name:
    Zinc transporter ZIP14
    Protein Accession:
    Q15043
    Secondary Accessions:
    • A6NH98
    • B4DIW3
    • B6EU88
    • D3DSR4
    • Q6ZME8
    • Q96BB3

    Protein attributes for SLC39A14 Gene

    Size:
    492 amino acids
    Molecular mass:
    54212 Da
    Quaternary structure:
    • Homotrimer.
    SequenceCaution:
    • Sequence=BAA06685.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC39A14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A14 Gene

Proteomics data for SLC39A14 Gene at MOPED

Post-translational modifications for SLC39A14 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn77 and Asn102

No data available for DME Specific Peptides for SLC39A14 Gene

Domains for SLC39A14 Gene

Gene Families for SLC39A14 Gene

Protein Domains for SLC39A14 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

S39AE_HUMAN
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.:
    • Q15043
genes like me logo Genes that share domains with SLC39A14: view

Function for SLC39A14 Gene

Molecular function for SLC39A14 Gene

UniProtKB/Swiss-Prot Function: May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake.

Gene Ontology (GO) - Molecular Function for SLC39A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity IDA 15642354
GO:0015093 ferrous iron transmembrane transporter activity IEA --
GO:0046873 metal ion transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC39A14: view
genes like me logo Genes that share phenotypes with SLC39A14: view

Animal Models for SLC39A14 Gene

MGI Knock Outs for SLC39A14:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC39A14 Gene

Localization for SLC39A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A14 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, lamellipodium. Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC39A14 Gene COMPARTMENTS Subcellular localization image for SLC39A14 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
golgi apparatus 4
cytosol 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC39A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 15642354
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SLC39A14: view

Pathways for SLC39A14 Gene

genes like me logo Genes that share pathways with SLC39A14: view

Gene Ontology (GO) - Biological Process for SLC39A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006826 iron ion transport --
GO:0006829 zinc II ion transport --
GO:0006882 cellular zinc ion homeostasis IDA 15642354
GO:0015684 ferrous iron transport --
GO:0030001 metal ion transport --
genes like me logo Genes that share ontologies with SLC39A14: view

Compounds for SLC39A14 Gene

(1) HMDB Compounds for SLC39A14 Gene

Compound Synonyms Cas Number PubMed IDs
Iron
  • Armco iron
7439-89-6

(1) PharmGKB related drug/compound annotations for SLC39A14 Gene

Drug/compound Annotation
nortriptyline CA
genes like me logo Genes that share compounds with SLC39A14: view

Transcripts for SLC39A14 Gene

Unigene Clusters for SLC39A14 Gene

Solute carrier family 39 (zinc transporter), member 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A14 Gene

No ASD Table

Relevant External Links for SLC39A14 Gene

GeneLoc Exon Structure for
SLC39A14
ECgene alternative splicing isoforms for
SLC39A14

Expression for SLC39A14 Gene

mRNA expression in normal human tissues for SLC39A14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC39A14 Gene

This gene is overexpressed in Liver (13.0) and Pancreas (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC39A14 Gene

SOURCE GeneReport for Unigene cluster for SLC39A14 Gene Hs.491232

mRNA Expression by UniProt/SwissProt for SLC39A14 Gene

Q15043-S39AE_HUMAN
Tissue specificity: Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes.
genes like me logo Genes that share expressions with SLC39A14: view

Orthologs for SLC39A14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC39A14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC39A14 36
  • 99.11 (n)
  • 99.18 (a)
SLC39A14 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC39A14 36
  • 86.48 (n)
  • 89.55 (a)
SLC39A14 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC39A14 36
  • 89.89 (n)
  • 90.37 (a)
SLC39A14 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc39a14 36
  • 84.98 (n)
  • 87.04 (a)
Slc39a14 16
Slc39a14 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC39A14 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 88 (a)
OneToMany
-- 37
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc39a14 36
  • 80.99 (n)
  • 83.47 (a)
chicken
(Gallus gallus)
Aves SLC39A14 36
  • 78.96 (n)
  • 83.22 (a)
SLC39A14 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC39A14 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a14 36
  • 70.33 (n)
  • 73.46 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC799782 36
  • 63.93 (n)
  • 62.75 (a)
SLC39A14 37
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-140 37
  • 19 (a)
ManyToMany
Y55F3BL.2 36
  • 49.33 (n)
  • 40.25 (a)
Y55F3BL.2 37
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKE4 37
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToMany
Species with no ortholog for SLC39A14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A14 Gene

ENSEMBL:
Gene Tree for SLC39A14 (if available)
TreeFam:
Gene Tree for SLC39A14 (if available)

Paralogs for SLC39A14 Gene

Selected SIMAP similar genes for SLC39A14 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for SLC39A14 Gene

genes like me logo Genes that share paralogs with SLC39A14: view

Variants for SLC39A14 Gene

Sequence variations from dbSNP and Humsavar for SLC39A14 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs8594 -- 22,422,303(+) CACAC(A/G/T)GCTTG utr-variant-3-prime, intron-variant
rs750668 -- 22,400,031(+) AGAGC(A/T)TTGTA intron-variant
rs870215 -- 22,400,624(-) CACAA(C/T)GACGG intron-variant
rs896375 -- 22,404,585(+) AGAGA(A/G)GCAGA intron-variant
rs896376 -- 22,404,629(+) GGCGG(A/G)CGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A14 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
nsv518646 CNV Gain 19592680
nsv831266 CNV Loss 17160897
essv1932 CNV CNV 17122850
nsv6116 CNV Insertion 18451855
nsv890671 CNV Loss 21882294
esv1010019 CNV Deletion 20482838
esv2736746 CNV Deletion 23290073
nsv398059 CNV Loss 16902084
esv2736747 CNV Deletion 23290073
dgv451n21 CNV Loss 19592680
nsv8321 CNV Gain 18304495

Relevant External Links for SLC39A14 Gene

HapMap Linkage Disequilibrium report
SLC39A14

Disorders for SLC39A14 Gene

Relevant External Links for SLC39A14

Genetic Association Database (GAD)
SLC39A14
Human Genome Epidemiology (HuGE) Navigator
SLC39A14
genes like me logo Genes that share disorders with SLC39A14: view

No data available for UniProtKB/Swiss-Prot for SLC39A14 Gene

Publications for SLC39A14 Gene

  1. Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14. (PMID: 15642354) Taylor K.M. … Nicholson R.I. (FEBS Lett. 2005) 3 4 23
  2. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PMID: 12659941) Taylor K.M. … Nicholson R.I. (Biochim. Biophys. Acta 2003) 2 3 4
  3. The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells. (PMID: 18524764) Gao J. … Enns C.A. (J. Biol. Chem. 2008) 3 23
  4. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 3 4
  5. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E. … Dorak M.T. (Mol. Hum. Reprod. 2010) 3 49

Products for SLC39A14 Gene

Sources for SLC39A14 Gene

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