Aliases for SLC39A14 Gene
External Ids for SLC39A14 Gene
Previous GeneCards Identifiers for SLC39A14 Gene
This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017]
GeneCards Summary for SLC39A14 Gene
SLC39A14 (Solute Carrier Family 39 Member 14) is a Protein Coding gene. Diseases associated with SLC39A14 include Hypermanganesemia With Dystonia 2 and Dystonia 2. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. GO annotations related to this gene include ferrous iron transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A8.
UniProtKB/Swiss-Prot for SLC39A14 Gene
Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron.