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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC39A14 Gene

protein-coding   GIFtS: 55
GCID: GC08P022224

solute carrier family 39 (zinc transporter), member 14

(Previous names: solute carrier family 39 (metal ion transporter), member...)
 Explore 12 diseases affiliated with
SLC39A14 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC39A14    

Aliases
for SLC39A14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 141 2     LZT-Hs42 3
ZIP141 2 3     ZIP-142 3
NET341 2     LIV-1 Subfamily Of ZIP Zinc Transporter 42 3
Solute Carrier Family 39 (Metal Ion Transporter), Member 141 2     Cig191
KIAA00621 3     Zinc Transporter ZIP142
Solute Carrier Family 39 Member 142 3     Zrt-, Irt-Like Protein 142
Zrt- And Irt-Like Protein 142 3     

External Ids:    HGNC: 208581   Entrez Gene: 235162   Ensembl: ENSG000001046357   OMIM: 6087365   UniProtKB: Q150433   

Export aliases for SLC39A14 gene to outside databases

Previous GC identifers: GC08P022246 GC08P022280 GC08P020766


Summaries
for SLC39A14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC39A14:
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid
metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14
belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson,
2003 (PubMed 12659941)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: S39AE_HUMAN, Q15043
Function: May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter
with a preference for zinc uptake




Genomic Views
for SLC39A14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC39A14 gene promoter:
         HFH-3   FOXI1   AML1a   HOXA5   Sox9   Cdc5   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SLC39A14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC39A14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.2

SLC39A14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A14 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P022224:  view genomic region     (about GC identifiers)

Start:
 22,224,762 bp from pter      End:
 22,291,642 bp from pter
Size:
 66,881 bases      Orientation:
 plus strand

Proteins
for SLC39A14 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S39AE_HUMAN, Q15043 (See protein sequence)
Recommended Name: Zinc transporter ZIP14 precursor  
Size: 492 amino acids; 54212 Da
Subunit: Homotrimer
Subcellular location: Cell membrane; Multi-pass membrane protein (Potential). Cell projection, lamellipodium.
Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae
Sequence caution: Sequence=BAA06685.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NH98 B4DIW3 B6EU88 D3DSR4 Q6ZME8 Q96BB3
Alternative splicing: 3 isoforms:  Q15043-1   Q15043-2   Q15043-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC39A14: NX_Q15043

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15043

    • SLC39A14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001121903.1  NP_001128625.1  NP_001128626.1  NP_056174.2  

    ENSEMBL proteins: 
     ENSP00000352779   ENSP00000428789   ENSP00000240095   ENSP00000370635   ENSP00000289952  
     ENSP00000430315   ENSP00000428905   ENSP00000430629   ENSP00000429328   ENSP00000430564  
     ENSP00000427981  
    Reactome Protein details: Q15043
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals SLC39A14 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC39A14

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA15642354
    GO:0016021integral to membrane IDA--


    SLC39A14 for ontologies           About GeneDecksing



    SLC39A14 Antibody Products: 
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    Uscn Antibodies for SLC39A14
    ThermoFisher Antibodies for SLC39A14

    Assay Products for SLC39A14: 
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    Uscn ELISAs and CLIAs for SLC39A14

    Protein Domains /
    Families
    for SLC39A14 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC39A14 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003689 ZIP

    Graphical View of Domain Structure for InterPro Entry Q15043

    ProtoNet protein and cluster: Q15043

    1 Blocks protein family: IPB003689 Zinc transporter ZIP

    UniProtKB/Swiss-Prot: S39AE_HUMAN, Q15043
    Similarity: Belongs to the ZIP transporter (TC 2.A.5) family


    Function
    for SLC39A14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S39AE_HUMAN, Q15043
    Function: May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter
    with a preference for zinc uptake

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC39A14
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC39A14 (see all 59):
    hsa-miR-3607-3p hsa-miR-4254 hsa-miR-429 hsa-miR-218-1* hsa-miR-218 hsa-miR-4275 hsa-miR-105 hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC39A14 (see all 7)
    OriGene shRNA RFP: SLC39A14
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC39A14 

    Cell Line
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    Search LifeMap BioReagents cell lines for SLC39A14

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A14

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005385zinc ion transmembrane transporter activity IDA15642354
    GO:0015093ferrous iron transmembrane transporter activity IEA--
    GO:0046873metal ion transmembrane transporter activity ----


    SLC39A14 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Slc39a14tm1Thir for SLC39A14
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc39a14):
     growth/size  homeostasis/metabolism  limbs/digits/tail  skeleton 

    SLC39A14 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC39A14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Zinc transporters
    		Zinc transporters1.00
    		Zinc influx into cells by the SLC39 gene family0.59
    		Metal ion SLC transporters0.68
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for SLC39A14 (see all 6)
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Metal ion SLC transporters
    Zinc transporters



    SLC39A14 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC39A14

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SLC39A14 (Q150433 ENSP000002899524) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006826iron ion transport ----
    GO:0006829zinc ion transport ----
    GO:0006882cellular zinc ion homeostasis IDA15642354
    GO:0015684ferrous iron transport ----
    GO:0055085transmembrane transport TAS--


    SLC39A14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC39A14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC39A14

    1 HMDB Compound for SLC39A14    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--
    Search CenterWatch for drugs/clinical trials and news about SLC39A14 / S39AE 

    Transcripts
    for SLC39A14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC39A14 gene (4 alternative transcripts): 
    NM_001128431.2  NM_001135153.1  NM_001135154.1  NM_015359.4  

    Unigene Cluster for SLC39A14:

    Solute carrier family 39 (zinc transporter), member 14
    Hs.491232  [show with all ESTs]
    Unigene Representative Sequence: NM_001135153
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359741(uc003xbp.4) ENST00000520644 ENST00000240095(uc011kzg.2)
    ENST00000381237(uc003xbq.4 uc011kzh.2) ENST00000289952 ENST00000524285
    ENST00000520832 ENST00000519960 ENST00000522881 ENST00000517552 ENST00000517370
    ENST00000518348

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC39A14
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC39A14 (see all 59):
    hsa-miR-3607-3p hsa-miR-4254 hsa-miR-429 hsa-miR-218-1* hsa-miR-218 hsa-miR-4275 hsa-miR-105 hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC39A14 (see all 7)
    OriGene shRNA RFP: SLC39A14
    OriGene siRNA: SLC39A14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC39A14
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC39A14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC39A14

    Additional cDNA sequence: 

    AF026940.1 AK022446.1 AK172810.1 AK295807.1 BC000068.1 BC015770.1 BX648538.1 D31887.1 

    13 DOTS entries:

    DT.218975  DT.99936455  DT.121472861  DT.92443177  DT.121472847  DT.91955200  DT.95182317  DT.97846013 
    DT.100786883  DT.100786887  DT.121472851  DT.121472876  DT.92443193 

    24/333 AceView cDNA sequences (see all 333):

    AA360426 AA861358 W70013 BM129028 AL044654 AA936839 BC000068 BQ181999 
    R63975 AI963417 AI298275 BF983926 CA420607 BU430687 BQ221268 AA320304 
    BQ447753 BM479121 BU621277 CA416282 W45525 BM790700 AV658546 Z38513 

    GeneLoc Exon Structure


    Expression
    for SLC39A14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC39A14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTCAAAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC39A14 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneEndochondral Facial BonesBone
    BoneThoracic RibBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)

    See SLC39A14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC39A14

    SOURCE GeneReport for Unigene cluster: Hs.491232

    UniProtKB/Swiss-Prot: S39AE_HUMAN, Q15043
    Tissue specificity: Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland,
    left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood
    leukocytes

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A14

    Orthologs
    for SLC39A14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC39A14 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC39A141 solute carrier family 39 (zinc transporter), member more 74.44(n)
    77.33(a)    		   429550  XM_427108.3  XP_427108.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC39A146
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL343443.1(226233-237335)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX730811.12   -- 78.52(n)    BX730811.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7997821 zinc transporter ZIP14-like 66.81(n)
    68.89(a)    		   799782  XM_001340066.4  XP_001340102.4 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y55F3BL.21 Protein Y55F3BL.2 47.35(n)
    37.24(a)    		   190312  NM_067594.2  NP_499995.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons IAR16
    		 IAA-alanine resistance protein 1
    		 18(a)
    		 1 → many
    		 1(25521204-25524175)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 metal cation transporter, putative, expressed
    		 19(a)
    		 1 → many
    		 8(22984381-22992760)


    ENSEMBL Gene Tree for SLC39A14 (if available)
    TreeFam Gene Tree for SLC39A14 (if available) 

    Paralogs
    for SLC39A14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC39A14 gene
    SLC39A102  SLC39A52  SLC39A82  SLC39A42  SLC39A132  SLC39A122  SLC39A62  SLC39A72  
    3 SIMAP similar genes for SLC39A14 using alignment to 7 protein entries:     S39AE_HUMAN (see all proteins):
    SLC39A8    SLC39A12    SLC39A4

    SLC39A14 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC39A14
    PGOHUM00000245260


    Genomic Variants
    for SLC39A14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1407 NCBI SNPs in SLC39A14 are shown (see all 1407)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1397156711,2
    		--22222786(+) GGTGGC/TGGGCT 3 -- us2k10--------
    rs24043301,2
    		--22222847(+) tgggaG/Agggga 3 -- us2k1 trp32Minor allele frequency- A:0.16CSA WA 120
    rs1869003811,2
    		--22222866(+) TGAACC/TGAGAT 3 -- us2k10--------
    rs360473551,2
    		C--22222914(+) GTCTC-/AAAAAA 3 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1924012581,2
    		--22223050(+) GGGTAA/GATATG 4 -- us2k10--------
    rs1143504951,2
    		F,--22223438(+) CTCCTT/CTTCCA 4 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1453001711,2
    		--22223465(+) TGTGGC/TGGGGA 4 -- us2k10--------
    rs1843023581,2
    		--22223611(+) CAAGAC/GATATC 4 -- us2k10--------
    rs735419811,2
    		C,F,--22223753(+) AAGTAA/GTATGA 4 -- us2k14Minor allele frequency- G:0.05WA EA 242
    rs69860651,2
    		C,F,H,--22223794(+) GCAAGC/TTCCTG 4 -- us2k17Minor allele frequency- T:0.04NS NA WA 912

    HapMap Linkage Disequilibrium report for SLC39A14 (22224762 - 22291642 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for SLC39A14
         2 CNVs: 2746 3726
         2 Indels: 13039 33457

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    Disorders / Diseases
    for SLC39A14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC39A14 for disorders           About GeneDecksing

    OMIM gene information: 608736    OMIM disorders: --

    12 diseases for SLC39A14:    About MalaCards
    acrodermatitis enteropathica    fibrous histiocytoma    malignant fibrous histiocytoma    enteropathica
    iron overload    acrodermatitis    histiocytoma    cytomegalovirus infection
    hemochromatosis    colorectal cancer    sarcoma    thyroiditis

    Human Genome Epidemiology (HuGE) Navigator: SLC39A14 (1 document)

    Export disorders for SLC39A14 gene to outside databases

    Publications
    for SLC39A14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC39A14 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with SLC39A14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PubMed id 12659941)1, 2, 3 Taylor K.M. and Nicholson R.I. (2003)
    2. Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14. (PubMed id 15642354)1, 2, 9 Taylor K.M.... Nicholson R.I. (2005)
    3. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N....Tabata S. (1994)
    4. The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells. (PubMed id 18524764)1, 9 Gao J....Enns C.A. (2008)
    5. Physiologic implications of metal-ion transport by ZIP 14 and ZIP8. (PubMed id 22318508)1 Jenkitkasemwong S....Knutson M.D. (2012)
    6. Coordinate expression and localization of iron and zin c transporters explain iron-zinc interactions during uptake in Caco-2 cells: imp lications for iron uptake at the enterocyte. (PubMed id 22137264)1 Iyengar V....Nair K.M. (2012)
    7. ZIP14 zinc transporter downregulation and zinc depleti on in the development and progression of hepatocellular cancer. (PubMed id 21373779)1 Franklin R.B....Costello L.C. (2012)
    8. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    9. Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway. (PubMed id 20938052)1 Thorsen K....A9rntoft T.F. (2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for SLC39A14 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing SLC39A14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23516 HGNC: 20858 AceView: SLC39A14 Ensembl:ENSG00000104635 euGenes: HUgn23516
    ECgene: SLC39A14 H-InvDB: SLC39A14

    Other Databases showing SLC39A14 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0062

    Specialized Databases showing SLC39A14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC39A14 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC39A14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC39A14 gene:
    Search GeneIP for patents involving SLC39A14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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