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SLC39A14 Gene

protein-coding   GIFtS: 59
GCID: GC08P022224

Solute Carrier Family 39 (Zinc Transporter), Member 14

(Previous names: solute carrier family 39 (metal ion transporter), member...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 141 2     LIV-1 Subfamily Of ZIP Zinc Transporter 42 3
Solute Carrier Family 39 (Metal Ion Transporter), Member 141 2     NET342
Solute Carrier Family 39 Member 142 3     cig192
Zrt- And Irt-Like Protein 142 3     Zinc Transporter ZIP142
LZT-Hs42 3     Zrt-, Irt-Like Protein 142
ZIP-142 3     KIAA00623
ZIP142 3     

External Ids:    HGNC: 208581   Entrez Gene: 235162   Ensembl: ENSG000001046357   OMIM: 6087365   UniProtKB: Q150433   

Export aliases for SLC39A14 gene to outside databases

Previous GC identifers: GC08P022246 GC08P022280 GC08P020766


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC39A14 Gene:
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and
lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation.
SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and
Nicholson, 2003 (PubMed 12659941)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC39A14 Gene:
SLC39A14 (solute carrier family 39 (zinc transporter), member 14) is a protein-coding gene. Diseases associated with SLC39A14 include acrodermatitis, and enteropathica. GO annotations related to this gene include zinc ion transmembrane transporter activity and ferrous iron transmembrane transporter activity. An important paralog of this gene is SLC39A10.

UniProtKB/Swiss-Prot: S39AE_HUMAN, Q15043
Function: May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion
transporter with a preference for zinc uptake




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC39A14 gene promoter:
         HFH-3   FOXI1   AML1a   HOXA5   Sox9   Cdc5   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SLC39A14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC39A14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.2

SLC39A14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A14 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P022224:  view genomic region     (about GC identifiers)

Start:
22,224,762 bp from pter      End:
22,291,642 bp from pter
Size:
66,881 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S39AE_HUMAN, Q15043 (See protein sequence)
Recommended Name: Zinc transporter ZIP14 precursor  
Size: 492 amino acids; 54212 Da
Subunit: Homotrimer
Sequence caution: Sequence=BAA06685.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NH98 B4DIW3 B6EU88 D3DSR4 Q6ZME8 Q96BB3
Alternative splicing: 3 isoforms:  Q15043-1   Q15043-2   Q15043-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC39A14: NX_Q15043

Explore proteomics data for SLC39A14 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn77, Asn102
  • Modification sites at PhosphoSitePlus

  • See SLC39A14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001121903.1  NP_001128625.1  NP_001128626.1  NP_056174.2  

    ENSEMBL proteins: 
     ENSP00000352779   ENSP00000428789   ENSP00000240095   ENSP00000370635   ENSP00000289952  
     ENSP00000430315   ENSP00000428905   ENSP00000430629   ENSP00000429328   ENSP00000430564  
     ENSP00000427981  
    Reactome Protein details: Q15043

    SLC39A14 Human Recombinant Protein Products:

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    Novus Biologicals SLC39A14 Proteins
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    Cloud-Clone Corp. Proteins for SLC39A14

    SLC39A14 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 14
    SLC39 family of metal ion transporters

    1 InterPro protein domain:
     IPR003689 ZIP

    Graphical View of Domain Structure for InterPro Entry Q15043

    ProtoNet protein and cluster: Q15043

    1 Blocks protein domain: IPB003689 Zinc transporter ZIP

    UniProtKB/Swiss-Prot: S39AE_HUMAN, Q15043
    Similarity: Belongs to the ZIP transporter (TC 2.A.5) family


    SLC39A14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S39AE_HUMAN, Q15043
    Function: May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion
    transporter with a preference for zinc uptake

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005385zinc ion transmembrane transporter activity IDA15642354
    GO:0015093ferrous iron transmembrane transporter activity IEA--
    GO:0046873metal ion transmembrane transporter activity ----
         
    SLC39A14 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc39a14):
     growth/size/body  homeostasis/metabolism  limbs/digits/tail  skeleton 

    SLC39A14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc39a14tm1Thir for SLC39A14

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC39A14
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC39A14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC39A14

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC39A14:
    hsa-mir-1 (MIRT023528), hsa-mir-15b-5p (MIRT046493), hsa-mir-33a-5p (MIRT028244), hsa-mir-155-5p (MIRT020522), hsa-mir-16-5p (MIRT031421), hsa-mir-9-5p (MIRT021386)

    Block miRNA regulation of human, mouse, rat SLC39A14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC39A14 (see all 59):
    hsa-miR-3607-3p hsa-miR-4254 hsa-miR-429 hsa-miR-218-1* hsa-miR-218 hsa-miR-4275 hsa-miR-105 hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC39A14

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): SLC39A14 (NM_015359)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC39A14
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S39AE_HUMAN, Q15043: Cell membrane; Multi-pass membrane protein (Potential). Cell projection, lamellipodium.
    Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum4
    golgi apparatus4
    cytosol1
    endosome1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA15642354
    GO:0016020membrane ----

    SLC39A14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC39A14 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    2Metal ion SLC transporters
    Metal ion SLC transporters
    Zinc influx into cells by the SLC39 gene family0.00
    Zinc transporters0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC39A14
        Zinc influx into cells by the SLC39 gene family



    SLC39A14 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC39A14
    Interactions:

        Search GeneGlobe Interaction Network for SLC39A14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for SLC39A14 (Q150433 ENSP000002899524) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    SLC30A5ENSP000003798364STRING: ENSP00000379836
    SLC30A6ENSP000002825874STRING: ENSP00000282587
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006826iron ion transport ----
    GO:0006829zinc ion transport ----
    GO:0006882cellular zinc ion homeostasis IDA15642354
    GO:0015684ferrous iron transport ----
    GO:0030001metal ion transport ----

    SLC39A14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC39A14 (S39AE)

    1 HMDB Compound for SLC39A14    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC39A14 gene (4 alternative transcripts): 
    NM_001128431.2  NM_001135153.1  NM_001135154.1  NM_015359.4  

    Unigene Cluster for SLC39A14:

    Solute carrier family 39 (zinc transporter), member 14
    Hs.491232  [show with all ESTs]
    Unigene Representative Sequence: NM_001135153
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359741(uc003xbp.4) ENST00000520644 ENST00000240095(uc011kzg.2)
    ENST00000381237(uc003xbq.4 uc011kzh.2) ENST00000289952 ENST00000524285
    ENST00000520832 ENST00000519960 ENST00000522881 ENST00000517552 ENST00000517370
    ENST00000518348
    miRNA
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    Block miRNA regulation of human, mouse, rat SLC39A14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC39A14 (see all 59):
    hsa-miR-3607-3p hsa-miR-4254 hsa-miR-429 hsa-miR-218-1* hsa-miR-218 hsa-miR-4275 hsa-miR-105 hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC39A14
      QuantiFast Probe-based Assays in human, mouse, rat SLC39A14

    Additional mRNA sequence: 

    AF026940.1 AK022446.1 AK172810.1 AK295807.1 BC000068.1 BC015770.1 BX648538.1 D31887.1 

    13 DOTS entries:

    DT.218975  DT.99936455  DT.121472861  DT.92443177  DT.121472847  DT.91955200  DT.95182317  DT.97846013 
    DT.100786883  DT.100786887  DT.121472851  DT.121472876  DT.92443193 

    Selected AceView cDNA sequences (see all 333):

    BC000068 BG287763 CB162054 BG565537 AL518959 BE047175 BG105197 CR595575 
    BU430687 AA320304 BU178508 CR590468 CN483083 BM479121 CA444766 BM790700 
    AI419643 D31887 AI963417 BQ447753 AF026940 AI830876 CA424719 AW961246 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC39A14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCAAAAAT
    SLC39A14 Expression
    About this image


    SLC39A14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mandibular Condyle
     
     Thyroid (Endocrine System)
     
     Smooth Muscle (Muscoskeletal System)
     
     Pancreas (Endocrine System)
     
     Adrenal Gland (Endocrine System)
    SLC39A14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC39A14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.491232

    UniProtKB/Swiss-Prot: S39AE_HUMAN, Q15043
    Tissue specificity: Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid
    gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral
    blood leukocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC39A14 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc39a141 , 5 solute carrier family 39 (zinc transporter), member more1, 5 84.98(n)1
    87.04(a)1
      14 (36.32 cM)5
    2130531  NM_144808.41  NP_659057.21 
     703034695 
    chicken
    (Gallus gallus)
    Aves SLC39A141 solute carrier family 39 (zinc transporter), member more 78.96(n)
    83.22(a)
      429550  XM_004950857.1  XP_004950914.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC39A146
    solute carrier family 39 (zinc transporter), membe...
    81(a)
    1 ↔ 1
    GL343443.1(226233-237335)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX730811.12   -- 78.52(n)    BX730811.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7997821 zinc transporter ZIP14-like 63.93(n)
    62.75(a)
      799782  XM_005171766.1  XP_005171823.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y55F3BL.21 Y55F3BL.2 49.33(n)
    40.25(a)
      190312  NM_067594.2  NP_499995.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YKE46
    Zinc transporter; localizes to the ER; null mutant...
    24(a)
    1 → many
    IX(309386-310426) YIL023C


    ENSEMBL Gene Tree for SLC39A14 (if available)
    TreeFam Gene Tree for SLC39A14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC39A14 gene
    SLC39A102  SLC39A52  SLC39A82  SLC39A62  SLC39A122  SLC39A42  SLC39A132  SLC39A72  
    3 SIMAP similar genes for SLC39A14 using alignment to 8 protein entries:     S39AE_HUMAN (see all proteins):
    SLC39A8    SLC39A12    SLC39A4

    SLC39A14 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC39A14
    PGOHUM00000245260


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC39A14 (see all 1669)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397156711,2
    --22222786(+) GGTGGC/TGGGCT 3 -- us2k10--------
    rs24043301,2
    C,F--22222847(+) tgggaG/Agggga 3 -- us2k1 trp32Minor allele frequency- A:0.16CSA WA 120
    rs1869003811,2
    --22222866(+) TGAACC/TGAGAT 3 -- us2k10--------
    rs360473551,2
    C--22222914(+) GTCTC-/AAAAAA 3 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1924012581,2
    --22223050(+) GGGTAA/GATATG 4 -- us2k10--------
    rs1143504951,2
    F--22223438(+) CTCCTT/CTTCCA 4 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1453001711,2
    --22223465(+) TGTGGC/TGGGGA 4 -- us2k10--------
    rs1843023581,2
    --22223611(+) CAAGAC/GATATC 4 -- us2k10--------
    rs735419811,2
    C,F--22223753(+) AAGTAA/GTATGA 4 -- us2k14Minor allele frequency- G:0.05WA EA 242
    rs69860651,2
    C,F,H--22223794(+) GCAAGC/TTCCTG 4 -- us2k17Minor allele frequency- T:0.04NS NA WA 912

    HapMap Linkage Disequilibrium report for SLC39A14 (22224762 - 22291642 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC39A14 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1010019CNV Deletion20482838
    esv2736746CNV Deletion23290073
    esv2736747CNV Deletion23290073
    nsv6116CNV Insertion18451855
    nsv890671CNV Loss21882294
    nsv831266CNV Loss17160897
    dgv451n21CNV Loss19592680
    nsv398059CNV Loss16902084
    nsv518646CNV Gain19592680
    nsv8321CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC39A14
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC39A14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 608736    OMIM disorders: --

    11 diseases for SLC39A14:    
    About MalaCards
    acrodermatitis    enteropathica    acrodermatitis enteropathica    fibrous histiocytoma
    histiocytoma    hemochromatosis    cytomegalovirus infection    sarcoma
    colorectal cancer    thyroiditis    hepatitis


    SLC39A14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC39A14
    Human Genome Epidemiology (HuGE) Navigator: SLC39A14 (1 document)

    Export disorders for SLC39A14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SLC39A14 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with SLC39A14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PubMed id 12659941)1, 2, 3 Taylor K.M. and Nicholson R.I. (Biochim. Biophys. Acta 2003)
    2. Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14. (PubMed id 15642354)1, 2, 9 Taylor K.M.... Nicholson R.I. (FEBS Lett. 2005)
    3. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    4. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    5. The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells. (PubMed id 18524764)1, 9 Gao J....Enns C.A. (J. Biol. Chem. 2008)
    6. Zip14 expression induced by lipopolysaccharides in macrophages attenuates inflammatory response. (PubMed id 23052185)1 Sayadi A....Bard-Chapeau E.A. (Inflamm. Res. 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (Mol. Endocrinol. 2013)
    9. Coordinate expression and localization of iron and zinc transporters explain iron-zinc interactions during uptake in Caco-2 cells: implications for iron uptake at the enterocyte. (PubMed id 22137264)1 Iyengar V....Nair K.M. (J. Nutr. Biochem. 2012)
    10. Physiologic implications of metal-ion transport by ZIP14 and ZIP8. (PubMed id 22318508)1 Jenkitkasemwong S....Knutson M.D. (Biometals 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 23516 HGNC: 20858 AceView: SLC39A14 Ensembl:ENSG00000104635 euGenes: HUgn23516
    ECgene: SLC39A14 H-InvDB: SLC39A14

    (According to HUGE)
    About This Section

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    HUGE: KIAA0062

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC39A14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC39A14 gene:
    Search GeneIP for patents involving SLC39A14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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