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Aliases for SLC39A12 Gene

Aliases for SLC39A12 Gene

  • Solute Carrier Family 39 (Zinc Transporter), Member 12 2 3
  • Solute Carrier Family 39 (Metal Ion Transporter), Member 12 2 3
  • LIV-1 Subfamily Of ZIP Zinc Transporter 8 3 4
  • Solute Carrier Family 39 Member 12 3 4
  • Zrt- And Irt-Like Protein 12 3 4
  • LZT-Hs8 3 4
  • ZIP-12 3 4
  • Zinc Transporter ZIP12 3
  • BA570F3.1 3
  • ZIP12 4

External Ids for SLC39A12 Gene

Summaries for SLC39A12 Gene

Entrez Gene Summary for SLC39A12 Gene

  • Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Aug 2008]

GeneCards Summary for SLC39A12 Gene

SLC39A12 (Solute Carrier Family 39 (Zinc Transporter), Member 12) is a Protein Coding gene. GO annotations related to this gene include metal ion transmembrane transporter activity. An important paralog of this gene is SLC39A6.

UniProtKB/Swiss-Prot for SLC39A12 Gene

  • Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A12 Gene

Genomics for SLC39A12 Gene

Genomic Location for SLC39A12 Gene

Start:
17,951,839 bp from pter
End:
18,043,292 bp from pter
Size:
91,454 bases
Orientation:
Plus strand

Genomic View for SLC39A12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC39A12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A12 Gene

Regulatory Elements for SLC39A12 Gene

Proteins for SLC39A12 Gene

  • Protein details for SLC39A12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q504Y0-S39AC_HUMAN
    Recommended name:
    Zinc transporter ZIP12
    Protein Accession:
    Q504Y0
    Secondary Accessions:
    • B7Z2Y9
    • B7ZL35
    • C9JJL4
    • F5GX72
    • Q49AN8
    • Q4G0L3
    • Q5VWV8
    • Q5VWV9
    • Q6NZY5
    • Q96NN4

    Protein attributes for SLC39A12 Gene

    Size:
    691 amino acids
    Molecular mass:
    76666 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC39A12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A12 Gene

Proteomics data for SLC39A12 Gene at MOPED

Post-translational modifications for SLC39A12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC39A12 Gene

No data available for DME Specific Peptides for SLC39A12 Gene

Domains for SLC39A12 Gene

Gene Families for SLC39A12 Gene

Protein Domains for SLC39A12 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

S39AC_HUMAN
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.:
    • Q504Y0
genes like me logo Genes that share domains with SLC39A12: view

Function for SLC39A12 Gene

Molecular function for SLC39A12 Gene

UniProtKB/Swiss-Prot Function: Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia.

Gene Ontology (GO) - Molecular Function for SLC39A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity IEA --
GO:0046873 metal ion transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC39A12: view
genes like me logo Genes that share phenotypes with SLC39A12: view

miRNA for SLC39A12 Gene

miRTarBase miRNAs that target SLC39A12

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC39A12 Gene

Localization for SLC39A12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC39A12 Gene COMPARTMENTS Subcellular localization image for SLC39A12 gene
Compartment Confidence
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC39A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0031982 vesicle IDA 24769233
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with SLC39A12: view

Pathways for SLC39A12 Gene

SuperPathways for SLC39A12 Gene

No Data Available

Interacting Proteins for SLC39A12 Gene

Gene Ontology (GO) - Biological Process for SLC39A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0010975 regulation of neuron projection development IEA --
GO:0030001 metal ion transport --
GO:0031113 regulation of microtubule polymerization IEA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SLC39A12: view

No data available for Pathways by source for SLC39A12 Gene

Transcripts for SLC39A12 Gene

Unigene Clusters for SLC39A12 Gene

Solute carrier family 39 (zinc transporter), member 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2:
SP3: - -
SP4: -

Relevant External Links for SLC39A12 Gene

GeneLoc Exon Structure for
SLC39A12
ECgene alternative splicing isoforms for
SLC39A12

Expression for SLC39A12 Gene

mRNA expression in normal human tissues for SLC39A12 Gene

mRNA differential expression in normal tissues according to GTEx for SLC39A12 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (6.8), Brain - Frontal Cortex (BA9) (6.5), Brain - Amygdala (6.2), Brain - Hippocampus (6.2), Brain - Putamen (basal ganglia) (6.1), Brain - Cortex (5.8), and Brain - Nucleus accumbens (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC39A12 Gene

SOURCE GeneReport for Unigene cluster for SLC39A12 Gene Hs.350895

mRNA Expression by UniProt/SwissProt for SLC39A12 Gene

Q504Y0-S39AC_HUMAN
Tissue specificity: Expressed in brain and eye.
genes like me logo Genes that share expressions with SLC39A12: view

Orthologs for SLC39A12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC39A12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC39A12 36
  • 99.42 (n)
  • 99.28 (a)
SLC39A12 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC39A12 36
  • 87 (n)
  • 83.79 (a)
SLC39A12 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC39A12 36
  • 87.32 (n)
  • 83.74 (a)
SLC39A12 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc39a12 36
  • 81.03 (n)
  • 78.17 (a)
Slc39a12 16
Slc39a12 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC39A12 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC39A12 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc39a12 36
  • 80.99 (n)
  • 78.7 (a)
chicken
(Gallus gallus)
Aves SLC39A12 36
  • 69.58 (n)
  • 63.55 (a)
SLC39A12 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC39A12 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a12 36
  • 60.05 (n)
  • 53.82 (a)
Str.5321 36
zebrafish
(Danio rerio)
Actinopterygii slc39a4 37
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-140 37
  • 18 (a)
ManyToMany
Y55F3BL.2 37
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKE4 37
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToMany
Species with no ortholog for SLC39A12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A12 Gene

ENSEMBL:
Gene Tree for SLC39A12 (if available)
TreeFam:
Gene Tree for SLC39A12 (if available)

Paralogs for SLC39A12 Gene

Selected SIMAP similar genes for SLC39A12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC39A12: view

Variants for SLC39A12 Gene

Sequence variations from dbSNP and Humsavar for SLC39A12 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs473919 -- 17,958,474(-) GATGG(C/G)AGTAG intron-variant
rs475853 -- 17,976,147(-) aaaat(C/T)caggt intron-variant
rs483822 -- 17,965,388(-) GGAAT(C/T)GTTTT intron-variant
rs491995 -- 17,955,079(-) AATCC(C/T)CAGAG intron-variant
rs508196 -- 17,974,944(-) aatac(A/G)gtaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A12 Gene

Variant ID Type Subtype PubMed ID
nsv528116 CNV Loss 19592680
nsv894914 CNV Loss 21882294
esv2733672 CNV Deletion 23290073
esv1273302 CNV Deletion 17803354
esv2733683 CNV Deletion 23290073

Relevant External Links for SLC39A12 Gene

HapMap Linkage Disequilibrium report
SLC39A12

Disorders for SLC39A12 Gene

Relevant External Links for SLC39A12

Genetic Association Database (GAD)
SLC39A12
Human Genome Epidemiology (HuGE) Navigator
SLC39A12
genes like me logo Genes that share disorders with SLC39A12: view

No data available for UniProtKB/Swiss-Prot for SLC39A12 Gene

Publications for SLC39A12 Gene

  1. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PMID: 12659941) Taylor K.M. … Nicholson R.I. (Biochim. Biophys. Acta 2003) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Examination of the zinc transporter gene, SLC39A12. (PMID: 16311021) Bly M. (Schizophr. Res. 2006) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 49

Products for SLC39A12 Gene

Sources for SLC39A12 Gene

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