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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC39A12 Gene

protein-coding   GIFtS: 51
GCID: GC10P018280

Solute Carrier Family 39 (Zinc Transporter), Member 12

(Previous names: solute carrier family 39 (metal ion transporter), member...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 121 2     ZIP-122 3
Solute Carrier Family 39 (Metal Ion Transporter), Member 121 2     LIV-1 Subfamily Of ZIP Zinc Transporter 82 3
Solute Carrier Family 39 Member 122 3     bA570F3.12
Zrt- And Irt-Like Protein 122 3     Zinc Transporter ZIP122
LZT-Hs82 3     ZIP123

External Ids:    HGNC: 208601   Entrez Gene: 2210742   Ensembl: ENSG000001484827   OMIM: 6087345   UniProtKB: Q504Y03   

Export aliases for SLC39A12 gene to outside databases

Previous GC identifers: GC00U912990 GC10P018244 GC10P017906


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC39A12 Gene:
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and
lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation.
SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and
Nicholson, 2003 (PubMed 12659941)).(supplied by OMIM, Aug 2008)

GeneCards Summary for SLC39A12 Gene: 
SLC39A12 (solute carrier family 39 (zinc transporter), member 12) is a protein-coding gene. Diseases associated with SLC39A12 include choroiditis, and schizophrenia. GO annotations related to this gene include metal ion transmembrane transporter activity. An important paralog of this gene is SLC39A10.

UniProtKB/Swiss-Prot: S39AC_HUMAN, Q504Y0
Function: Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC39A12 gene promoter:
         AML1a   HTF   CUTL1   NF-E2 p45   POU3F2   E4BP4   C/EBPalpha   CHOP-10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC39A12 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC39A12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC39A12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.33   Ensembl cytogenetic band:  10p12.33   HGNC cytogenetic band: 10p12.33

SLC39A12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A12 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P018280:  view genomic region     (about GC identifiers)

Start:
18,240,768 bp from pter      End:
18,332,221 bp from pter
Size:
91,454 bases      Orientation:
plus strand

1 alternative location:
Chr10+,NW_003315932 380,630-390,672     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S39AC_HUMAN, Q504Y0 (See protein sequence)
Recommended Name: Zinc transporter ZIP12  
Size: 691 amino acids; 76666 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B7ZL35 C9JJL4 Q49AN8 Q4G0L3 Q5VWV8 Q5VWV9 Q6NZY5 Q96NN4
Alternative splicing: 4 isoforms:  Q504Y0-1   Q504Y0-2   Q504Y0-3   Q504Y0-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC39A12: NX_Q504Y0

Explore proteomics data for SLC39A12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q504Y0

  • SLC39A12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC39A12 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001138667.1  NP_001269662.1  NP_001269663.1  NP_689938.2  

    ENSEMBL proteins: 
     ENSP00000366591   ENSP00000366588   ENSP00000366586   ENSP00000440445  

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    Cloud-Clone Corp. Proteins for SLC39A12 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLC39A12 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 12 
    SLC39 family of metal ion transporters

    1 InterPro protein domain:
     IPR003689 ZIP

    Graphical View of Domain Structure for InterPro Entry Q504Y0

    ProtoNet protein and cluster: Q504Y0

    1 Blocks protein domain: IPB003689 Zinc transporter ZIP

    UniProtKB/Swiss-Prot: S39AC_HUMAN, Q504Y0
    Similarity: Belongs to the ZIP transporter (TC 2.A.5) family


    SLC39A12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S39AC_HUMAN, Q504Y0
    Function: Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046873metal ion transmembrane transporter activity IEA--
         
    SLC39A12 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SLC39A12:
     Increased circadian rhythm amp  Increased gamma-H2AX phosphory  Increased homologous recombina 

    Animal Models:
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SLC39A12:
    hsa-miR-3163
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC39A12

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006829zinc ion transport IEA--
    GO:0030001metal ion transport ----
    GO:0055085transmembrane transport ----

    SLC39A12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC39A12 (S39AC)

    Search CenterWatch for drugs/clinical trials and news about SLC39A12 / S39AC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC39A12 gene (4 alternative transcripts): 
    NM_001145195.1  NM_001282733.1  NM_001282734.1  NM_152725.3  

    Unigene Cluster for SLC39A12:

    Solute carrier family 39 (zinc transporter), member 12
    Hs.350895  [show with all ESTs]
    Unigene Representative Sequence: NM_001145195
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377374 ENST00000377371 ENST00000377369(uc001ipo.2 uc001ipn.2 uc001ipp.2 uc010qck.1)
    ENST00000539911

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SLC39A12:
    hsa-miR-3163
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK055061.1 AK295294.1 AK303735.1 BC035118.1 BC047635.1 BC065917.1 BC094700.1 BC117323.1 
    BC143551.1 

    3 DOTS entries:

    DT.40307674  DT.100685984  DT.99957548 

    24/27 AceView cDNA sequences (see all 27):

    CA394889 BQ636346 BP350394 BC047635 NM_152725 BM920889 CD104800 BC065917 
    BI916564 BI480768 BG704677 BC035118 AK055061 AA317203 BP360953 BG704146 
    BG701781 BG704089 BI550618 BG702075 BI547691 BG108781 BI544657 BG702746 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A12    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                                                            
    SP2:                                                                                                            
    SP3:                                                        -     -                                             
    SP4:                                                                                -                           


    ECgene alternative splicing isoforms for SLC39A12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC39A12 expression in normal human tissues (normalized intensities)      SLC39A12 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTTAGTA
    SLC39A12 Expression
    About this image


    SLC39A12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 8 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Spinal Cord (Nervous System)
             spinal cord/lateral wall/ventricular layer   
     
     Neural Crest (Gastrulation Derivatives)
             mesenchyme   
     
     Mesoderm (Gastrulation Derivatives)
             mesenchyme   

    See SLC39A12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC39A12

    SOURCE GeneReport for Unigene cluster: Hs.350895

    UniProtKB/Swiss-Prot: S39AC_HUMAN, Q504Y0
    Tissue specificity: Expressed in brain and eye

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLC39A12 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc39a121 , 5 solute carrier family 39 (zinc transporter), member more1, 5 81.03(n)1
    78.17(a)1
      2 (10.56 cM)5
    2774681  NM_001012305.21  NP_001012305.11 
     143883165 
    chicken
    (Gallus gallus)
    Aves SLC39A121 solute carrier family 39 (zinc transporter), member more 70.19(n)
    64.11(a)
      420514  XM_418616.3  XP_418616.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC39A126
    Uncharacterized protein
    87(a)
    1 ↔ 1
    6(17921954-17948288)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.53212 Transcribed sequence with weak similarity to protein more 75.36(n)    BX743375.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc39a46
    solute carrier family 39 (zinc transporter), membe...
    61(a)
    1 ↔ 1
    19(1112201-1119410)


    ENSEMBL Gene Tree for SLC39A12 (if available)
    TreeFam Gene Tree for SLC39A12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC39A12 gene
    SLC39A102  SLC39A52  SLC39A82  SLC39A62  SLC39A142  SLC39A42  SLC39A72  SLC39A132  
    4 SIMAP similar genes for SLC39A12 using alignment to 2 protein entries:     S39AC_HUMAN (see all proteins):
    SLC39A10    SLC39A8    SLC39A4    SLC39A14

    SLC39A12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2176 SNPs in SLC39A12 are shown (see all 2176)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0375204
    A breast cancer sample4--see VAR_0375202 P T mis40--------
    rs574502401,2
    C--17907298(+) AGTGA-/GTGT  
            
    GTGTG
    2 -- int10--------
    rs110116551,2
    C,F--18238791(+) GTGGTA/GGAGGT 2 -- us2k15Minor allele frequency- G:0.40NA WA 10
    rs2012358381,2
    C--18238947(+) CTTGG-/CTCA  
            
    TCACT
    2 -- us2k10--------
    rs1885725751,2
    --18238999(+) CAGTTC/TTTAAA 2 -- us2k10--------
    rs1445517911,2
    --18239071(+) GGTGGA/GTTCGT 2 -- us2k10--------
    rs1392528741,2
    --18239200(+) AGGAGC/TGAAGC 2 -- us2k10--------
    rs1424758241,2
    C--18239219(+) TTCCCG/TGTGAG 2 -- us2k10--------
    rs1927701421,2
    --18239232(+) TGACAG/TCTCAT 2 -- us2k10--------
    rs1459590681,2
    --18239268(+) AGCAGC/TAGCAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC39A12 (18240768 - 18332221 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC39A12:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2733683CNV Deletion23290073
    esv1273302CNV Deletion17803354
    esv2733672CNV Deletion23290073
    nsv894914CNV Loss21882294
    nsv528116CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC39A12
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC39A12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608734    OMIM disorders: --

    4 diseases for SLC39A12:    About MalaCards
    choroiditis    schizophrenia    alzheimer's disease    prostatitis


    SLC39A12 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SLC39A12
    Human Genome Epidemiology (HuGE) Navigator: SLC39A12 (3 documents)

    Export disorders for SLC39A12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC39A12 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SLC39A12)
        Utopia: connect your pdf to the dynamic
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    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (2008)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    4. Examination of the zinc transporter gene, SLC39A12. (PubMed id 16311021)1, 2 Bly M. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PubMed id 12659941)1, 3 Taylor K.M. and Nicholson R.I. (2003)
    7. Neurulation and neurite extension require the zinc tra nsporter ZIP12 (slc39a12). (PubMed id 23716681)1 Chowanadisai W....Messerli M.A. (2013)
    8. Genetic variants in novel pathways influence blood pre ssure and cardiovascular disease risk. (PubMed id 21909115)4  ....Johnson T. (2011)
    9. Genomewide pharmacogenomic study of metabolic side ef fects to antipsychotic drugs. (PubMed id 20195266)4 Adkins D.E....van den Oord E.J. (2010)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221074 HGNC: 20860 AceView: SLC39A12 Ensembl:ENSG00000148482 euGenes: HUgn221074
    ECgene: SLC39A12 H-InvDB: SLC39A12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC39A12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC39A12 gene:
    Search GeneIP for patents involving SLC39A12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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