Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC39A12 Gene

protein-coding   GIFtS: 51
GCID: GC10P018280

Solute Carrier Family 39 (Zinc Transporter), Member 12

(Previous names: solute carrier family 39 (metal ion transporter), member...)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 121 2     ZIP-122 3
Solute Carrier Family 39 (Metal Ion Transporter), Member 121 2     LIV-1 Subfamily Of ZIP Zinc Transporter 82 3
Solute Carrier Family 39 Member 122 3     bA570F3.12
Zrt- And Irt-Like Protein 122 3     Zinc Transporter ZIP122
LZT-Hs82 3     ZIP123

External Ids:    HGNC: 208601   Entrez Gene: 2210742   Ensembl: ENSG000001484827   OMIM: 6087345   UniProtKB: Q504Y03   

Export aliases for SLC39A12 gene to outside databases

Previous GC identifers: GC00U912990 GC10P018244 GC10P017906


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC39A12 Gene:
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and
lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation.
SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and
Nicholson, 2003 (PubMed 12659941)).(supplied by OMIM, Aug 2008)

GeneCards Summary for SLC39A12 Gene:
SLC39A12 (solute carrier family 39 (zinc transporter), member 12) is a protein-coding gene. GO annotations related to this gene include metal ion transmembrane transporter activity. An important paralog of this gene is SLC39A10.

UniProtKB/Swiss-Prot: S39AC_HUMAN, Q504Y0
Function: Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC39A12 gene promoter:
         AML1a   HTF   CUTL1   NF-E2 p45   POU3F2   E4BP4   C/EBPalpha   CHOP-10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC39A12 promoter sequence
   Search Chromatin IP Primers for SLC39A12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC39A12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.33   Ensembl cytogenetic band:  10p12.33   HGNC cytogenetic band: 10p12.33

SLC39A12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A12 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P018280:  view genomic region     (about GC identifiers)

Start:
18,240,768 bp from pter      End:
18,332,221 bp from pter
Size:
91,454 bases      Orientation:
plus strand

1 alternative location:
Chr10+,NW_003315932 380,630-390,672     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: S39AC_HUMAN, Q504Y0 (See protein sequence)
Recommended Name: Zinc transporter ZIP12  
Size: 691 amino acids; 76666 Da
Secondary accessions: B7ZL35 C9JJL4 Q49AN8 Q4G0L3 Q5VWV8 Q5VWV9 Q6NZY5 Q96NN4
Alternative splicing: 4 isoforms:  Q504Y0-1   Q504Y0-2   Q504Y0-3   Q504Y0-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC39A12: NX_Q504Y0

Explore proteomics data for SLC39A12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC39A12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001138667.1  NP_001269662.1  NP_001269663.1  NP_689938.2  

    ENSEMBL proteins: 
     ENSP00000366591   ENSP00000366588   ENSP00000366586   ENSP00000440445  

    SLC39A12 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC39A12
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC39A12
    GenScript Custom Purified and Recombinant Proteins Services for SLC39A12
    Novus Biologicals SLC39A12 Proteins
    Novus Biologicals SLC39A12 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC39A12

     
    Search eBioscience for Proteins for SLC39A12 

     
    antibodies-online proteins for SLC39A12 

     
    antibodies-online peptides for SLC39A12

    SLC39A12 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SLC39A12
    OriGene Custom Antibody Services for SLC39A12
    Novus Biologicals SLC39A12 Antibodies
    Abcam antibodies for SLC39A12
    Cloud-Clone Corp. Antibodies for SLC39A12
    ThermoFisher Antibodies for SLC39A12
    antibodies-online antibodies for SLC39A12 (13 products) 

    SLC39A12 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC39A12
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC39A12
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLC39A12
    Cloud-Clone Corp. CLIAs for SLC39A12
    Search eBioscience for ELISAs for SLC39A12 
    antibodies-online kits for SLC39A12 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 12
    SLC39 family of metal ion transporters

    1 InterPro protein domain:
     IPR003689 ZIP

    Graphical View of Domain Structure for InterPro Entry Q504Y0

    ProtoNet protein and cluster: Q504Y0

    1 Blocks protein domain: IPB003689 Zinc transporter ZIP

    UniProtKB/Swiss-Prot: S39AC_HUMAN, Q504Y0
    Similarity: Belongs to the ZIP transporter (TC 2.A.5) family


    Find genes that share domains with SLC39A12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S39AC_HUMAN, Q504Y0
    Function: Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046873metal ion transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC39A12           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SLC39A12:
     Increased circadian rhythm amp  Increased gamma-H2AX phosphory  Increased homologous recombina 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC39A12

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC39A12:
    hsa-mir-335-5p (MIRT019023)

    Block miRNA regulation of human, mouse, rat SLC39A12 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SLC39A12:
    hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidSLC39A12 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC39A12
    Predesigned siRNA for gene silencing in human, mouse, rat SLC39A12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC39A12

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC39A12 (see all 11)
    OriGene ORF clones in mouse, rat for SLC39A12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC39A12 (NM_001145195)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC39A12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC39A12

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC39A12
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC39A12 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    S39AC_HUMAN, Q504Y0: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC39A12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC39A12
    Interactions:

        Search GeneGlobe Interaction Network for SLC39A12

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006829zinc ion transport IEA--
    GO:0030001metal ion transport ----
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with SLC39A12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC39A12 (S39AC)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC39A12 gene (4 alternative transcripts): 
    NM_001145195.1  NM_001282733.1  NM_001282734.1  NM_152725.3  

    Unigene Cluster for SLC39A12:

    Solute carrier family 39 (zinc transporter), member 12
    Hs.350895  [show with all ESTs]
    Unigene Representative Sequence: NM_001145195
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377374 ENST00000377371 ENST00000377369(uc001ipo.2 uc001ipn.2 uc001ipp.2 uc010qck.1)
    ENST00000539911
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC39A12 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SLC39A12:
    hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidSLC39A12 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC39A12
    Predesigned siRNA for gene silencing in human, mouse, rat SLC39A12
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC39A12 (see all 11)
    OriGene ORF clones in mouse, rat for SLC39A12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC39A12 (NM_001145195)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC39A12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC39A12
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC39A12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC39A12
      QuantiTect SYBR Green Assays in human, mouse, rat SLC39A12
      QuantiFast Probe-based Assays in human, mouse, rat SLC39A12

    Additional mRNA sequence: 

    AK055061.1 AK295294.1 AK303735.1 BC035118.1 BC047635.1 BC065917.1 BC094700.1 BC117323.1 
    BC143551.1 

    3 DOTS entries:

    DT.40307674  DT.100685984  DT.99957548 

    Selected AceView cDNA sequences (see all 27):

    CA394889 CD104800 BC047635 BC065917 BI916564 AA317203 BQ636346 BI480768 
    NM_152725 BC035118 AK055061 BG704677 BP350394 BM920889 BI547691 BG702075 
    BG108781 BI550618 BP360953 BG704089 BG701781 BG704146 BI544657 BG702746 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A12    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                                                            
    SP2:                                                                                                            
    SP3:                                                        -     -                                             
    SP4:                                                                                -                           


    ECgene alternative splicing isoforms for SLC39A12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC39A12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTTAGTA
    SLC39A12 Expression
    About this image


    SLC39A12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Diencephalic Roof Plate
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
    SLC39A12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC39A12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.350895

    UniProtKB/Swiss-Prot: S39AC_HUMAN, Q504Y0
    Tissue specificity: Expressed in brain and eye

        Custom PCR Arrays for SLC39A12
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC39A12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC39A12
    QuantiTect SYBR Green Assays in human, mouse, rat SLC39A12
    QuantiFast Probe-based Assays in human, mouse, rat SLC39A12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC39A12 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc39a121 , 5 solute carrier family 39 (zinc transporter), member more1, 5 81.03(n)1
    78.17(a)1
      2 (10.56 cM)5
    2774681  NM_001012305.21  NP_001012305.11 
     143883165 
    chicken
    (Gallus gallus)
    Aves SLC39A121 solute carrier family 39 (zinc transporter), member more 69.58(n)
    63.55(a)
      420514  XM_004939251.1  XP_004939308.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC39A126
    solute carrier family 39 (zinc transporter), membe...
    87(a)
    1 ↔ 1
    6(17921954-17948288)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.53212 Transcribed sequence with weak similarity to protein more 75.36(n)    BX743375.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc39a46
    solute carrier family 39 (zinc transporter), membe...
    61(a)
    1 ↔ 1
    19(1112201-1119410) ENSDARG00000059361
    worm
    (Caenorhabditis elegans)
    Secernentea Y55F3BL.26
    tag-1406
    --
    Protein TAG-140, isoform a (tag-140) mRNA, complet...
    26(a)
    18(a)
    many ↔ many
    many ↔ many
    IV(807439-824941) WBGene00021936
    V(11463013-11466761) WBGene00006486
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YKE46
    Zinc transporter; localizes to the ER; null mutant...
    26(a)
    1 → many
    IX(309386-310426) YIL023C


    ENSEMBL Gene Tree for SLC39A12 (if available)
    TreeFam Gene Tree for SLC39A12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC39A12 gene
    SLC39A102  SLC39A52  SLC39A82  SLC39A62  SLC39A42  SLC39A142  SLC39A132  SLC39A72  
    4 SIMAP similar genes for SLC39A12 using alignment to 2 protein entries:     S39AC_HUMAN (see all proteins):
    SLC39A10    SLC39A8    SLC39A4    SLC39A14

    Find genes that share paralogs with SLC39A12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC39A12 (see all 2176)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0375204
    A breast cancer sample4--see VAR_0375202 P T mis40--------
    rs574502401,2
    C--17907298(+) AGTGA-/GTGT  
            
    GTGTG
    2 -- int10--------
    rs110116551,2
    C,F--18238791(+) GTGGTA/GGAGGT 2 -- us2k15Minor allele frequency- G:0.40NA WA 10
    rs2012358381,2
    C--18238947(+) CTTGG-/CTCA  
            
    TCACT
    2 -- us2k10--------
    rs1885725751,2
    --18238999(+) CAGTTC/TTTAAA 2 -- us2k10--------
    rs1445517911,2
    --18239071(+) GGTGGA/GTTCGT 2 -- us2k10--------
    rs1392528741,2
    --18239200(+) AGGAGC/TGAAGC 2 -- us2k10--------
    rs1424758241,2
    C--18239219(+) TTCCCG/TGTGAG 2 -- us2k10--------
    rs1927701421,2
    --18239232(+) TGACAG/TCTCAT 2 -- us2k10--------
    rs1459590681,2
    --18239268(+) AGCAGC/TAGCAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC39A12 (18240768 - 18332221 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC39A12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733683CNV Deletion23290073
    esv1273302CNV Deletion17803354
    esv2733672CNV Deletion23290073
    nsv894914CNV Loss21882294
    nsv528116CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC39A12
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC39A12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608734    OMIM disorders: --


    Find genes that share disorders with SLC39A12           About GenesLikeMe

    Genetic Association Database (GAD): SLC39A12
    Human Genome Epidemiology (HuGE) Navigator: SLC39A12 (3 documents)

    Export disorders for SLC39A12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC39A12 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with SLC39A12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. Examination of the zinc transporter gene, SLC39A12. (PubMed id 16311021)1, 2 Bly M. (Schizophr. Res. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PubMed id 12659941)1, 3 Taylor K.M. and Nicholson R.I. (Biochim. Biophys. Acta 2003)
    7. Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). (PubMed id 23716681)1 Chowanadisai W....Messerli M.A. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    8. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PubMed id 21909115)4  ....Johnson T. (Nature 2011)
    9. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. (PubMed id 20195266)4 Adkins D.E....van den Oord E.J. (Mol. Psychiatry 2011)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 221074 HGNC: 20860 AceView: SLC39A12 Ensembl:ENSG00000148482 euGenes: HUgn221074
    ECgene: SLC39A12 H-InvDB: SLC39A12

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC39A12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC39A12 gene:
    Search GeneIP for patents involving SLC39A12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SLC39A12   OriGene RNAi products in human, mouse, rat for SLC39A12  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SLC39A12  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC39A12  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC39A12   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC39A12   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC39A12   OriGene Custom Protein Services for SLC39A12  

     
     
     Block miRNA regulation of human, mouse, rat SLC39A12 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC39A12
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC39A12 Predesigned siRNA for gene silencing in human, mouse, rat SLC39A12
     QuantiFast Probe-based Assays in human, mouse, rat SLC39A12 QuantiTect SYBR Green Assays in human, mouse, rat SLC39A12
     Custom PCR Arrays for SLC39A12 Search Chromatin IP Primers for SLC39A12
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC39A12  Search GeneGlobe Interaction Network for SLC39A12
     Regulatory tfbs in SLC39A12 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC39A12 GenScript cDNA clones with any tag delivered in your preferred vector for SLC39A12
     GenScript Custom Assay Services for SLC39A12 GenScript Custom overexpressing Cell Line Services for SLC39A12
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC39A12 (S39AC)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC39A12 antibodies
     SLC39A12 proteins
     SLC39A12 lysates
     Antibodies for SLC39A12
     See all of Abcam's Antibodies, Kits and Proteins for SLC39A12
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SLC39A12
     Antibodies for SLC39A12
     ELISAs for SLC39A12
     CLIAs for SLC39A12



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC39A12
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A12
     SwitchGear 3'UTR luciferase reporter plasmids for SLC39A12
     SwitchGear Promoter luciferase reporter plasmids for SLC39A12
     ThermoFisher Antibodies for SLC39A12
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC39A12
     Browse compounds at ApexBio
     Search Addgene for plasmids for SLC39A12
      Search eBioscience for proteins for SLC39A12
      Search eBioscience for elisas for SLC39A12
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SLC39A12
     antibodies-online antibodies for SLC39A12 (13 products)
     antibodies-online kits for SLC39A12 (6 products)
     antibodies-online peptides for SLC39A12
     antibodies-online proteins for SLC39A12
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC39A12 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4