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Aliases for SLC39A12 Gene

Aliases for SLC39A12 Gene

  • Solute Carrier Family 39 Member 12 2 3 4 5
  • Solute Carrier Family 39 (Metal Ion Transporter), Member 12 2 3
  • Solute Carrier Family 39 (Zinc Transporter), Member 12 2 3
  • LIV-1 Subfamily Of ZIP Zinc Transporter 8 3 4
  • Zrt- And Irt-Like Protein 12 3 4
  • LZT-Hs8 3 4
  • ZIP-12 3 4
  • Zinc Transporter ZIP12 3
  • BA570F3.1 3
  • ZIP12 4

External Ids for SLC39A12 Gene

Previous GeneCards Identifiers for SLC39A12 Gene

  • GC00U912990
  • GC10P018244
  • GC10P018280

Summaries for SLC39A12 Gene

Entrez Gene Summary for SLC39A12 Gene

  • Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Aug 2008]

GeneCards Summary for SLC39A12 Gene

SLC39A12 (Solute Carrier Family 39 Member 12) is a Protein Coding gene. Among its related pathways are Metal ion SLC transporters and NRF2 pathway. GO annotations related to this gene include metal ion transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A4.

UniProtKB/Swiss-Prot for SLC39A12 Gene

  • Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A12 Gene

Genomics for SLC39A12 Gene

Regulatory Elements for SLC39A12 Gene

Enhancers for SLC39A12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G017984 0.8 ENCODE 11.2 +32.3 32348 0.1 PKNOX1 JUN BACH1 EED RELB IKZF2 CREM TCF7L2 MTA2 BHLHE40 SLC39A12 MRC1 SLC39A12-AS1
GH10G017980 0.6 ENCODE 11.8 +30.1 30062 1.9 CTCF JUN CEBPB ZMYM3 EP300 JUND MAFF FOS MAFK NFE2L2 SLC39A12 MRC1 SLC39A12-AS1
GH10G017950 0.6 FANTOM5 10.3 -1.3 -1281 0.3 CTCF ZNF316 ZNF146 NFYA NFYB EMSY MRC1 SLC39A12 GC10P017900
GH10G017712 0.8 FANTOM5 ENCODE 4.2 -238.6 -238636 0.4 SMARCA4 MLLT1 ZMIZ1 STAM HACD1 VIM SLC39A12 LOC105376438 TMEM236
GH10G018289 0.3 FANTOM5 1.5 +338.1 338129 0.3 CACNB2 SLC39A12 ENSG00000235020 GC10P018346
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC39A12 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC39A12 Gene

17,951,839 bp from pter
18,043,292 bp from pter
91,454 bases
Plus strand

Genomic View for SLC39A12 Gene

Genes around SLC39A12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A12 Gene

Proteins for SLC39A12 Gene

  • Protein details for SLC39A12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc transporter ZIP12
    Protein Accession:
    Secondary Accessions:
    • B7Z2Y9
    • B7ZL35
    • C9JJL4
    • F5GX72
    • Q49AN8
    • Q4G0L3
    • Q5VWV8
    • Q5VWV9
    • Q6NZY5
    • Q96NN4

    Protein attributes for SLC39A12 Gene

    691 amino acids
    Molecular mass:
    76666 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC39A12 Gene


neXtProt entry for SLC39A12 Gene

Post-translational modifications for SLC39A12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC39A12 Gene

No data available for DME Specific Peptides for SLC39A12 Gene

Domains & Families for SLC39A12 Gene

Gene Families for SLC39A12 Gene

Protein Domains for SLC39A12 Gene


Suggested Antigen Peptide Sequences for SLC39A12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZIP transporter (TC 2.A.5) family.
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A12: view

Function for SLC39A12 Gene

Molecular function for SLC39A12 Gene

UniProtKB/Swiss-Prot Function:
Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia.

Gene Ontology (GO) - Molecular Function for SLC39A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity IBA --
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A12: view
genes like me logo Genes that share phenotypes with SLC39A12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC39A12

CRISPR Products

miRNA for SLC39A12 Gene

miRTarBase miRNAs that target SLC39A12

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC39A12 Gene

Localization for SLC39A12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC39A12 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for SLC39A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with SLC39A12: view

Pathways & Interactions for SLC39A12 Gene

SuperPathways for SLC39A12 Gene

SuperPathway Contained pathways
1 NRF2 pathway
2 Metal ion SLC transporters
genes like me logo Genes that share pathways with SLC39A12: view

Pathways by source for SLC39A12 Gene

2 BioSystems pathways for SLC39A12 Gene

Interacting Proteins for SLC39A12 Gene

Gene Ontology (GO) - Biological Process for SLC39A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006829 zinc II ion transport IEA --
GO:0006882 cellular zinc ion homeostasis IBA --
GO:0007165 signal transduction IBA,IEA --
genes like me logo Genes that share ontologies with SLC39A12: view

No data available for SIGNOR curated interactions for SLC39A12 Gene

Drugs & Compounds for SLC39A12 Gene

No Compound Related Data Available

Transcripts for SLC39A12 Gene

Unigene Clusters for SLC39A12 Gene

Solute carrier family 39 (zinc transporter), member 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP3: - -
SP4: -

Relevant External Links for SLC39A12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC39A12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC39A12 Gene

mRNA differential expression in normal tissues according to GTEx for SLC39A12 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.8), Brain - Frontal Cortex (BA9) (x6.5), Brain - Amygdala (x6.2), Brain - Hippocampus (x6.2), Brain - Putamen (basal ganglia) (x6.1), Brain - Cortex (x5.8), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for SLC39A12 Gene

This gene is overexpressed in Retina (41.3), Frontal cortex (20.3), and Heart (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC39A12 Gene

Protein tissue co-expression partners for SLC39A12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC39A12 Gene:


SOURCE GeneReport for Unigene cluster for SLC39A12 Gene:


mRNA Expression by UniProt/SwissProt for SLC39A12 Gene:

Tissue specificity: Expressed in brain and eye.

Evidence on tissue expression from TISSUES for SLC39A12 Gene

  • Nervous system(4.9)
  • Lung(4)
genes like me logo Genes that share expression patterns with SLC39A12: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC39A12 Gene

Orthologs for SLC39A12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC39A12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC39A12 34 35
  • 99.42 (n)
(Canis familiaris)
Mammalia SLC39A12 34 35
  • 87.32 (n)
(Bos Taurus)
Mammalia SLC39A12 34 35
  • 87 (n)
(Mus musculus)
Mammalia Slc39a12 34 16 35
  • 81.03 (n)
(Rattus norvegicus)
Mammalia Slc39a12 34
  • 80.99 (n)
(Monodelphis domestica)
Mammalia SLC39A12 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia SLC39A12 35
  • 56 (a)
(Gallus gallus)
Aves SLC39A12 34 35
  • 69.58 (n)
(Anolis carolinensis)
Reptilia SLC39A12 35
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a12 34
  • 60.05 (n)
Str.5321 34
(Danio rerio)
Actinopterygii slc39a4 35
  • 61 (a)
(Caenorhabditis elegans)
Secernentea Y55F3BL.2 35
  • 26 (a)
tag-140 35
  • 18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKE4 35
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
Species where no ortholog for SLC39A12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A12 Gene

Gene Tree for SLC39A12 (if available)
Gene Tree for SLC39A12 (if available)

Paralogs for SLC39A12 Gene

(4) SIMAP similar genes for SLC39A12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC39A12: view

Variants for SLC39A12 Gene

Sequence variations from dbSNP and Humsavar for SLC39A12 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_037520 A breast cancer sample
rs1000028503 -- 17,975,990(+) CCCCC(C/T)TACTG intron-variant
rs1000032683 -- 17,977,077(+) TGTTG(A/G)GTTCC intron-variant
rs1000037821 -- 18,013,051(+) GTGAC(A/G)TCTCT intron-variant
rs1000059985 -- 17,983,007(+) AACGC(A/G)GTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A12 Gene

Variant ID Type Subtype PubMed ID
esv1273302 CNV deletion 17803354
esv2733672 CNV deletion 23290073
esv2733683 CNV deletion 23290073
nsv1039655 CNV loss 25217958
nsv528116 CNV loss 19592680

Variation tolerance for SLC39A12 Gene

Residual Variation Intolerance Score: 90.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.20; 75.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC39A12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A12 Gene

Disorders for SLC39A12 Gene

Relevant External Links for SLC39A12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC39A12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A12 Gene

Publications for SLC39A12 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 64
  3. Examination of the zinc transporter gene, SLC39A12. (PMID: 16311021) Bly M. (Schizophr. Res. 2006) 3 4 64
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for SLC39A12 Gene

Sources for SLC39A12 Gene

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