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Aliases for SLC39A11 Gene

Aliases for SLC39A11 Gene

  • Solute Carrier Family 39 Member 11 2 3 4 5
  • Solute Carrier Family 39, Member 11 2 3
  • Zrt- And Irt-Like Protein 11 3 4
  • C17orf26 3 4
  • ZIP-11 3 4
  • ZIP11 3 4
  • Solute Carrier Family 39 (Metal Ion Transporter), Member 11 3
  • Chromosome 17 Open Reading Frame 26 2

External Ids for SLC39A11 Gene

Previous HGNC Symbols for SLC39A11 Gene

  • C17orf26

Previous GeneCards Identifiers for SLC39A11 Gene

  • GC17M071239
  • GC17M068153
  • GC17M070644
  • GC17M066033

Summaries for SLC39A11 Gene

GeneCards Summary for SLC39A11 Gene

SLC39A11 (Solute Carrier Family 39 Member 11) is a Protein Coding gene. GO annotations related to this gene include metal ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC39A11 Gene

  • Functions as a cellular zinc transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A11 Gene

Genomics for SLC39A11 Gene

Regulatory Elements for SLC39A11 Gene

Promoters for SLC39A11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC39A11 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC39A11 Gene

Chromosome:
17
Start:
72,645,946 bp from pter
End:
73,092,714 bp from pter
Size:
446,769 bases
Orientation:
Minus strand

Genomic View for SLC39A11 Gene

Genes around SLC39A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A11 Gene

Proteins for SLC39A11 Gene

  • Protein details for SLC39A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1S5-S39AB_HUMAN
    Recommended name:
    Zinc transporter ZIP11
    Protein Accession:
    Q8N1S5
    Secondary Accessions:
    • B2R8H7
    • Q8WZ81

    Protein attributes for SLC39A11 Gene

    Size:
    342 amino acids
    Molecular mass:
    35396 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC39A11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A11 Gene

Proteomics data for SLC39A11 Gene at MOPED

Post-translational modifications for SLC39A11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SLC39A11 Gene

Domains & Families for SLC39A11 Gene

Gene Families for SLC39A11 Gene

Protein Domains for SLC39A11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC39A11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N1S5

UniProtKB/Swiss-Prot:

S39AB_HUMAN :
  • Belongs to the ZIP transporter (TC 2.A.5) family.
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A11: view

Function for SLC39A11 Gene

Molecular function for SLC39A11 Gene

UniProtKB/Swiss-Prot Function:
Functions as a cellular zinc transporter.
genes like me logo Genes that share phenotypes with SLC39A11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC39A11

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC39A11 Gene

Localization for SLC39A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A11 Gene

Cell membrane; Multi-pass membrane protein. Nucleus. Cytoplasm. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC39A11 Gene COMPARTMENTS Subcellular localization image for SLC39A11 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
nucleus 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC39A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
GO:0005737 cytoplasm IEA,ISS --
GO:0016020 membrane IEA,IBA --
genes like me logo Genes that share ontologies with SLC39A11: view

Pathways & Interactions for SLC39A11 Gene

SuperPathways for SLC39A11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC39A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071577 zinc II ion transmembrane transport IEA,IBA --
genes like me logo Genes that share ontologies with SLC39A11: view

No data available for Pathways by source and SIGNOR curated interactions for SLC39A11 Gene

Drugs & Compounds for SLC39A11 Gene

No Compound Related Data Available

Transcripts for SLC39A11 Gene

Unigene Clusters for SLC39A11 Gene

Solute carrier family 39 (metal ion transporter), member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A11 Gene

No ASD Table

Relevant External Links for SLC39A11 Gene

GeneLoc Exon Structure for
SLC39A11
ECgene alternative splicing isoforms for
SLC39A11

Expression for SLC39A11 Gene

mRNA expression in normal human tissues for SLC39A11 Gene

Protein differential expression in normal tissues from HIPED for SLC39A11 Gene

This gene is overexpressed in Adipocyte (47.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC39A11 Gene



SOURCE GeneReport for Unigene cluster for SLC39A11 Gene Hs.221127

genes like me logo Genes that share expression patterns with SLC39A11: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC39A11 Gene

Orthologs for SLC39A11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC39A11 36
  • 99 (a)
OneToOne
SLC39A11 35
  • 99.5 (n)
  • 99.4 (a)
cow
(Bos Taurus)
Mammalia SLC39A11 35
  • 86.03 (n)
  • 89.52 (a)
SLC39A11 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC39A11 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc39a11 16
Slc39a11 36
  • 89 (a)
OneToOne
Slc39a11 35
  • 86.53 (n)
  • 90.72 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC39A11 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc39a11 35
  • 85.57 (n)
  • 88.66 (a)
chicken
(Gallus gallus)
Aves SLC39A11 35
  • 73.33 (n)
  • 74.33 (a)
SLC39A11 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC39A11 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16308 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a11 35
  • 68.39 (n)
  • 72.34 (a)
zebrafish
(Danio rerio)
Actinopterygii SLC39A11 36
  • 67 (a)
OneToOne
LOC101882215 35
  • 73.86 (n)
  • 77.45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007713 35
  • 55.22 (n)
  • 57.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13189 36
  • 55 (a)
OneToOne
CG13189 35
  • 58.01 (n)
  • 57.4 (a)
worm
(Caenorhabditis elegans)
Secernentea F59A3.4 35
  • 56.56 (n)
  • 58.75 (a)
F59A3.4 36
  • 58 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.554 35
Species with no ortholog for SLC39A11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A11 Gene

ENSEMBL:
Gene Tree for SLC39A11 (if available)
TreeFam:
Gene Tree for SLC39A11 (if available)

Paralogs for SLC39A11 Gene

No data available for Paralogs for SLC39A11 Gene

Variants for SLC39A11 Gene

Sequence variations from dbSNP and Humsavar for SLC39A11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2466517 - 72,947,851(+) CAGGG(C/T)CGTCT nc-transcript-variant, reference, missense
rs883786 -- 73,016,776(+) CTAAA(A/T)CTAGT intron-variant
rs891688 -- 72,795,686(-) CTTCT(A/G)TTGGG intron-variant
rs934339 -- 72,796,461(-) ACGGG(A/G)AGGGT intron-variant
rs934340 -- 72,796,418(-) GAATA(A/G)GAGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A11 Gene

Variant ID Type Subtype PubMed ID
nsv528666 CNV Loss 19592680
esv1118006 CNV Deletion 17803354
esv2716187 CNV Deletion 23290073
esv259495 OTHER Complex 20981092
esv259955 OTHER Complex 20981092
dgv3250n71 CNV Gain 21882294
dgv3251n71 CNV Loss 21882294
esv267646 CNV Insertion 20981092
esv259651 OTHER Complex 20981092
esv259893 OTHER Complex 20981092
nsv111666 CNV Insertion 16902084
esv1465732 CNV Insertion 17803354
nsv519333 CNV Loss 19592680
nsv517895 CNV Loss 19592680
esv6132 CNV Gain 19470904
nsv457899 CNV Loss 19166990
nsv525813 CNV Loss 19592680
nsv524320 CNV Gain 19592680
esv28025 CNV Loss 19812545
esv2669155 CNV Deletion 23128226
nsv442424 CNV CNV 18776908
esv24117 CNV Loss 19812545
esv2677783 CNV Deletion 23128226
nsv509667 CNV Insertion 20534489
nsv511060 CNV Complex 20534489
nsv2137 CNV Insertion 18451855
nsv164 CNV Insertion 15895083
esv1004601 CNV Insertion 20482838
nsv908730 CNV Loss 21882294
esv26793 CNV Loss 19812545
esv27281 CNV Loss 19812545
nsv528252 CNV Gain 19592680
nsv908731 CNV Loss 21882294
dgv3252n71 CNV Loss 21882294
nsv509669 CNV Insertion 20534489
nsv470599 CNV Loss 18288195
nsv523221 CNV Loss 19592680
esv2499710 CNV Insertion 19546169
nsv513479 CNV Insertion 21212237
esv1578515 CNV Insertion 17803354
nsv519473 CNV Loss 19592680
esv2716188 CNV Deletion 23290073
nsv908734 CNV Loss 21882294
esv1031977 CNV Insertion 17803354

Variation tolerance for SLC39A11 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.48; 77.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC39A11 Gene

HapMap Linkage Disequilibrium report
SLC39A11
Human Gene Mutation Database (HGMD)
SLC39A11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A11 Gene

Disorders for SLC39A11 Gene

Relevant External Links for SLC39A11

Genetic Association Database (GAD)
SLC39A11
Human Genome Epidemiology (HuGE) Navigator
SLC39A11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC39A11

No disorders were found for SLC39A11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A11 Gene

Publications for SLC39A11 Gene

  1. Comparative genomics of the SOX9 region in human and Fugu rubripes: conservation of short regulatory sequence elements within large intergenic regions. (PMID: 11707075) Bagheri-Fam S. … Pfeifer D. (Genomics 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide association study of smoking behaviours among Bangladeshi adults. (PMID: 24665060) Argos M. … Ahsan H. (J. Med. Genet. 2014) 3
  4. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila J.L. … Boerwinkle E. (Pharmacogenomics J. 2013) 3
  5. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PMID: 23956138) Foerster S. … Ritter C.A. (Proteomics 2013) 3

Products for SLC39A11 Gene

Sources for SLC39A11 Gene

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