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Aliases for SLC39A11 Gene

Aliases for SLC39A11 Gene

  • Solute Carrier Family 39 Member 11 2 3 4 5
  • Zrt- And Irt-Like Protein 11 3 4
  • C17orf26 3 4
  • ZIP-11 3 4
  • ZIP11 3 4
  • Solute Carrier Family 39 (Metal Ion Transporter), Member 11 3
  • Chromosome 17 Open Reading Frame 26 2
  • Solute Carrier Family 39, Member 11 2
  • Zinc Transporter ZIP11 3

External Ids for SLC39A11 Gene

Previous HGNC Symbols for SLC39A11 Gene

  • C17orf26

Previous GeneCards Identifiers for SLC39A11 Gene

  • GC17M071239
  • GC17M068153
  • GC17M070644
  • GC17M066033

Summaries for SLC39A11 Gene

GeneCards Summary for SLC39A11 Gene

SLC39A11 (Solute Carrier Family 39 Member 11) is a Protein Coding gene. Among its related pathways are Metal ion SLC transporters and NRF2 pathway. Gene Ontology (GO) annotations related to this gene include metal ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC39A11 Gene

  • Functions as a cellular zinc transporter.

Additional gene information for SLC39A11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A11 Gene

Genomics for SLC39A11 Gene

GeneHancer (GH) Regulatory Elements for SLC39A11 Gene

Promoters and enhancers for SLC39A11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I073091 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 552.7 +0.3 300 1.8 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B SIN3A ZNF2 YY1 POLR2B SLC39A11 CDC42EP4 ATG12P1
GH17I073066 Enhancer 1.3 FANTOM5 Ensembl ENCODE 22 +24.1 24119 3.2 ELF3 FOXA2 ARID4B BMI1 RAD21 ZNF48 ZSCAN9 RARA TCF12 FOS GC17M073068 ATG12P1 SLC39A11 CPSF4L
GH17I073010 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.5 +81.5 81457 0.9 HDGF FOXA2 ZNF48 TCF12 ZNF766 CBX5 GATA2 ATF7 NCOA1 REST SLC39A11 GC17M073068 ENSG00000264196
GH17I073012 Enhancer 1 Ensembl ENCODE 11.5 +79.1 79066 1.4 PKNOX1 ZFP64 KLF17 ZNF2 ZNF121 ZSCAN5C KLF7 EGR2 ZNF202 ZC3H11A SLC39A11 GC17M073068 ENSG00000264196
GH17I072120 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 4.7 +968.9 968886 8.6 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SOX9 SLC39A11 GC17P072122 GC17P072161 SOX9-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC39A11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC39A11 gene promoter:

Genomic Locations for SLC39A11 Gene

Genomic Locations for SLC39A11 Gene
446,769 bases
Minus strand

Genomic View for SLC39A11 Gene

Genes around SLC39A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A11 Gene

Proteins for SLC39A11 Gene

  • Protein details for SLC39A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc transporter ZIP11
    Protein Accession:
    Secondary Accessions:
    • B2R8H7
    • Q8WZ81

    Protein attributes for SLC39A11 Gene

    342 amino acids
    Molecular mass:
    35396 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC39A11 Gene


neXtProt entry for SLC39A11 Gene

Post-translational modifications for SLC39A11 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC39A11 Gene

Domains & Families for SLC39A11 Gene

Gene Families for SLC39A11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC39A11 Gene


Suggested Antigen Peptide Sequences for SLC39A11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZIP transporter (TC 2.A.5) family.
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A11: view

Function for SLC39A11 Gene

Molecular function for SLC39A11 Gene

UniProtKB/Swiss-Prot Function:
Functions as a cellular zinc transporter.

Phenotypes From GWAS Catalog for SLC39A11 Gene

Gene Ontology (GO) - Molecular Function for SLC39A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity ISS --
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A11: view
genes like me logo Genes that share phenotypes with SLC39A11: view

Animal Model Products

CRISPR Products

miRNA for SLC39A11 Gene

miRTarBase miRNAs that target SLC39A11

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC39A11 Gene

Localization for SLC39A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A11 Gene

Cell membrane; Multi-pass membrane protein. Nucleus. Cytoplasm. Golgi apparatus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC39A11 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
nucleus 4
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC39A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005794 Golgi apparatus ISS --
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA,IBA --
genes like me logo Genes that share ontologies with SLC39A11: view

Pathways & Interactions for SLC39A11 Gene

SuperPathways for SLC39A11 Gene

SuperPathway Contained pathways
1 NRF2 pathway
2 Metal ion SLC transporters
genes like me logo Genes that share pathways with SLC39A11: view

Pathways by source for SLC39A11 Gene

2 BioSystems pathways for SLC39A11 Gene

Gene Ontology (GO) - Biological Process for SLC39A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006829 zinc II ion transport IEA --
GO:0030001 metal ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC39A11: view

No data available for SIGNOR curated interactions for SLC39A11 Gene

Drugs & Compounds for SLC39A11 Gene

No Compound Related Data Available

Transcripts for SLC39A11 Gene

Unigene Clusters for SLC39A11 Gene

Solute carrier family 39 (metal ion transporter), member 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A11 Gene

No ASD Table

Relevant External Links for SLC39A11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC39A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC39A11 Gene

Protein differential expression in normal tissues from HIPED for SLC39A11 Gene

This gene is overexpressed in Adipocyte (47.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC39A11 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC39A11 Gene:


SOURCE GeneReport for Unigene cluster for SLC39A11 Gene:


Evidence on tissue expression from TISSUES for SLC39A11 Gene

  • Kidney(4.2)
  • Blood(4.1)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with SLC39A11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC39A11 Gene

Orthologs for SLC39A11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC39A11 33 34
  • 99.5 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
-- 34
  • 91 (a)
-- 34
  • 67 (a)
-- 34
  • 56 (a)
(Canis familiaris)
Mammalia SLC39A11 34
  • 87 (a)
(Mus musculus)
Mammalia Slc39a11 33 16 34
  • 86.53 (n)
(Bos Taurus)
Mammalia SLC39A11 33 34
  • 86.03 (n)
(Rattus norvegicus)
Mammalia Slc39a11 33
  • 85.57 (n)
(Monodelphis domestica)
Mammalia SLC39A11 34
  • 79 (a)
(Gallus gallus)
Aves SLC39A11 33 34
  • 73.33 (n)
(Anolis carolinensis)
Reptilia SLC39A11 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a11 33
  • 68.39 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16308 33
(Danio rerio)
Actinopterygii LOC101882215 33
  • 73.86 (n)
SLC39A11 34
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13189 33 34
  • 58.01 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007713 33
  • 55.22 (n)
(Caenorhabditis elegans)
Secernentea F59A3.4 33 34
  • 56.56 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.554 33
Species where no ortholog for SLC39A11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A11 Gene

Gene Tree for SLC39A11 (if available)
Gene Tree for SLC39A11 (if available)

Paralogs for SLC39A11 Gene

No data available for Paralogs for SLC39A11 Gene

Variants for SLC39A11 Gene

Sequence variations from dbSNP and Humsavar for SLC39A11 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs745762301 uncertain-significance, Ependymoma 72,849,640(-) C/A/T coding_sequence_variant, intron_variant, missense_variant
rs1000001775 -- 72,714,124(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000003818 -- 73,083,509(-) G/A intron_variant
rs1000007714 -- 72,863,401(-) A/C intron_variant
rs1000012393 -- 72,678,778(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A11 Gene

Variant ID Type Subtype PubMed ID
dgv1809e59 CNV tandem duplication 20981092
dgv3280n100 CNV loss 25217958
dgv5762n54 CNV loss 21841781
dgv5763n54 CNV loss 21841781
dgv5764n54 CNV loss 21841781
dgv5765n54 CNV loss 21841781
dgv5766n54 CNV loss 21841781
dgv5767n54 CNV loss 21841781
esv1004601 CNV insertion 20482838
esv1031977 CNV insertion 17803354
esv1118006 CNV deletion 17803354
esv1465732 CNV insertion 17803354
esv1578515 CNV insertion 17803354
esv24117 CNV loss 19812545
esv2499710 CNV insertion 19546169
esv2669155 CNV deletion 23128226
esv2677783 CNV deletion 23128226
esv26793 CNV loss 19812545
esv2716187 CNV deletion 23290073
esv2716188 CNV deletion 23290073
esv27281 CNV loss 19812545
esv28025 CNV loss 19812545
esv3302677 CNV tandem duplication 20981092
esv3302919 CNV tandem duplication 20981092
esv3303367 CNV mobile element insertion 20981092
esv3399532 CNV duplication 20981092
esv3406595 CNV duplication 20981092
esv3427219 CNV insertion 20981092
esv3443813 CNV insertion 20981092
esv3554749 CNV deletion 23714750
esv3582899 CNV loss 25503493
esv3641200 CNV loss 21293372
esv3641201 CNV loss 21293372
esv3641202 CNV loss 21293372
esv3641204 CNV loss 21293372
esv3641205 CNV loss 21293372
esv3641206 CNV loss 21293372
esv3641207 CNV loss 21293372
esv3641208 CNV loss 21293372
esv3641210 CNV loss 21293372
esv3641212 CNV loss 21293372
esv3893041 CNV loss 25118596
esv3893042 CNV loss 25118596
esv3893043 CNV loss 25118596
esv6132 CNV gain 19470904
nsv1056357 CNV loss 25217958
nsv1057488 CNV loss 25217958
nsv1059797 CNV loss 25217958
nsv111666 CNV insertion 16902084
nsv1117182 CNV tandem duplication 24896259
nsv1117184 CNV tandem duplication 24896259
nsv1123140 CNV deletion 24896259
nsv1129190 CNV insertion 24896259
nsv1129595 CNV tandem duplication 24896259
nsv1153339 CNV insertion 26484159
nsv1160498 CNV duplication 26073780
nsv164 CNV insertion 15895083
nsv2137 CNV insertion 18451855
nsv442424 CNV loss 18776908
nsv457899 CNV loss 19166990
nsv470599 CNV loss 18288195
nsv472237 CNV novel sequence insertion 20440878
nsv472372 CNV novel sequence insertion 20440878
nsv473143 CNV novel sequence insertion 20440878
nsv474129 CNV novel sequence insertion 20440878
nsv474381 CNV novel sequence insertion 20440878
nsv474921 CNV novel sequence insertion 20440878
nsv479419 CNV novel sequence insertion 20440878
nsv481047 CNV novel sequence insertion 20440878
nsv481179 CNV novel sequence insertion 20440878
nsv481222 CNV novel sequence insertion 20440878
nsv481346 CNV novel sequence insertion 20440878
nsv481373 CNV novel sequence insertion 20440878
nsv509667 CNV insertion 20534489
nsv509669 CNV insertion 20534489
nsv511060 OTHER complex 20534489
nsv513479 CNV insertion 21212237
nsv517895 CNV loss 19592680
nsv519333 CNV loss 19592680
nsv519473 CNV loss 19592680
nsv523221 CNV loss 19592680
nsv524320 CNV gain 19592680
nsv525813 CNV loss 19592680
nsv528252 CNV gain 19592680
nsv528666 CNV loss 19592680
nsv575975 CNV loss 21841781
nsv575983 CNV loss 21841781
nsv575986 CNV loss 21841781
nsv962366 CNV duplication 23825009

Variation tolerance for SLC39A11 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.48; 77.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC39A11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A11 Gene

Disorders for SLC39A11 Gene

Additional Disease Information for SLC39A11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC39A11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A11 Gene

Publications for SLC39A11 Gene

  1. Comparative genomics of the SOX9 region in human and Fugu rubripes: conservation of short regulatory sequence elements within large intergenic regions. (PMID: 11707075) Bagheri-Fam S … Pfeifer D (Genomics 2001) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PMID: 19451621) Landers JE … Brown RH (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for SLC39A11 Gene

Sources for SLC39A11 Gene

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