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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC39A10 Gene

protein-coding GIFtS: 54
GCID: GC02P196440

solute carrier family 39 (zinc transporter), member 10

(Previous names: solute carrier family 39 (metal ion transporter), member...)

Explore 2 diseases affiliated with
SLC39A10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 10¹ ²		DKFZp564L2123¹
Solute Carrier Family 39 (Metal Ion Transporter), Member 10¹ ²		FLJ90515¹
KIAA1265¹ ³		LZT-Hs2²
Solute Carrier Family 39 Member 10² ³		Zinc Transporter ZIP10²
Zrt- And Irt-Like Protein 10² ³		ZIP10³
ZIP-10² ³

External Ids:	HGNC: 20861¹	Entrez Gene: 57181²	Ensembl: ENSG00000196950⁷	OMIM: 608733⁵	UniProtKB: Q9ULF5³

Export aliases for SLC39A10 gene to outside databases

Previous GC identifers: GC00U912989 GC02P196724 GC02P196347 GC02P196229 GC02P188374

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC39A10:

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid

metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10

belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson,

2003 (PubMed 12659941)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: S39AA_HUMAN, Q9ULF5

Function: May act as a zinc-influx transporter

Gene Wiki entry for SLC39A10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC39A10 gene promoter:
FAC1 Sp1 HSF1short HSF1 (long) Lmo2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC39A10 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC39A10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC39A10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.3 Ensembl cytogenetic band: 2q32.3 HGNC cytogenetic band: 2q33.1

SLC39A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A10 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P196440: view genomic region (about GC identifiers)

Start:	196,440,701 bp from pter	End:	196,602,426 bp from pter
Size:	161,726 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S39AA_HUMAN, Q9ULF5 (See protein sequence)

Recommended Name: Zinc transporter ZIP10 precursor

Size: 831 amino acids; 94132 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Miscellaneous: High levels of expression are correlated with invasiveness in several breast cancer lines

Sequence caution: Sequence=BAA86579.1; Type=Erroneous initiation; Sequence=CAB43393.1; Type=Miscellaneous discrepancy;

Note=Contaminating sequence. Potential poly-A sequence;

Secondary accessions: A8K5C6 Q3MJA4 Q68CR5 Q6DKH6 Q9Y3Z1

Explore the universe of human proteins at neXtProt for SLC39A10: NX_Q9ULF5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9ULF5

SLC39A10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001120729.1 NP_065075.1

ENSEMBL proteins:

ENSP00000389640 ENSP00000386766 ENSP00000394469 ENSP00000352655 ENSP00000394995

ENSP00000406590 ENSP00000409272 ENSP00000437787

Reactome Protein details: Q9ULF5
Human Recombinant Protein Products for SLC39A10:

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	Uscn Proteins for SLC39A10

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--

SLC39A10 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC39A10 for domains About GeneDecksing

1 InterPro domain/family:

IPR003689 ZIP

Graphical View of Domain Structure for InterPro Entry Q9ULF5

ProtoNet protein and cluster: Q9ULF5

1 Blocks protein family: IPB003689 Zinc transporter ZIP

UniProtKB/Swiss-Prot: S39AA_HUMAN, Q9ULF5

Similarity: Belongs to the ZIP transporter (TC 2.A.5) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: S39AA_HUMAN, Q9ULF5

Function: May act as a zinc-influx transporter

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0046873	metal ion transmembrane transporter activity	IEA	--

SLC39A10 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC39A10

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		SwitchGear 3'UTR luciferase reporter plasmid: SLC39A10 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A10

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Zinc transporters

	Zinc transporters	1.00			Zinc influx into cells by the SLC39 gene family	0.59
	Metal ion SLC transporters	0.68

SLC-mediated transmembrane transport

	SLC-mediated transmembrane transport	1.00			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38
	Transmembrane transport of small molecules	0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 Reactome Pathways for SLC39A10 (see all 6)

	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Metal ion SLC transporters
	Zinc transporters

SLC39A10 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC39A10

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5 Interacting proteins for SLC39A10 (Q9ULF5³ ENSP00000352655⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NAPG	Q99747³	I2D: score=5
CLN3	Q13286³	I2D: score=1
ETS1	P14921³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006829	zinc ion transport	IEA	--
GO:0055085	transmembrane transport	TAS	--

SLC39A10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC39A10
Search CenterWatch for drugs/clinical trials and news about SLC39A10 / S39AA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC39A10 gene (2 alternative transcripts):

NM_001127257.1 NM_020342.2

Unigene Cluster for SLC39A10:

Solute carrier family 39 (zinc transporter), member 10

Hs.650158 [show with all ESTs]

Unigene Representative Sequence: NM_001127257

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000458054 ENST00000409086(uc002utg.4) ENST00000444421 ENST00000359634(uc002uth.4)

ENST00000430412(uc010zgp.2) ENST00000412905 ENST00000464301 ENST00000418005

ENST00000465851 ENST00000541054

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SLC39A10 Browse OriGene MicroRNA Expression Plasmids
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		hsa-miR-323-3p hsa-miR-300 hsa-miR-15a hsa-miR-199a-3p hsa-miR-128 hsa-miR-219-5p hsa-miR-30d hsa-miR-138-2*

		SwitchGear 3'UTR luciferase reporter plasmid: SLC39A10 3' UTR sequence

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Additional cDNA sequence:

AB033091.1 AK074996.1 AK291241.1 AK294771.1 AL050294.1 BC010371.1 BC029413.1 BC047493.1

BC073909.1 BC101516.1 BC112223.1 CR749813.1

11 DOTS entries:

DT.113693 DT.91753387 DT.121030412 DT.213677 DT.75184258 DT.121030387 DT.95260424 DT.99990819

DT.91753390 DT.95177423 DT.95275242

24/170 AceView cDNA sequences (see all 170):

AA282932 AW874409 N99716 AA491292 AI580405 BX489404 BM556605 AL042656

AA191514 CR599732 AW872826 AV705100 H18696 AB033091 BI597376 BM904169

AA283096 AA371057 AA482159 BM997974 AW675337 BC047493 AI434736 AI580886

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC39A10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTCCTTAT

About this image

SLC39A10 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Ovigerous Cord

Ovarian Somatic Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

See SLC39A10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC39A10

SOURCE GeneReport for Unigene cluster: Hs.650158

SABiosciences Custom PCR Arrays for SLC39A10

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC39A10 gene from 8/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC39A10¹	solute carrier family 39 (zinc transporter), member more	74.71(n) 72(a)		429005 XM_426562.3 XP_426562.2
lizard (Anolis carolinensis)	Reptilia	SLC39A10⁶	--	65(a)	1 ↔ 1	GL343280.1(1106064-1135274)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.9023²	Transcribed sequence with weak similarity to protein more	82.45(n)		CF783212.1
zebrafish (Danio rerio)	Actinopterygii	zgc63552²	hypothetical protein MGC63552	73.55(n)		393644 BC058056.1
fruit fly (Drosophila melanogaster)	Insecta	CG10006¹	CG10006	50.41(n) 40.33(a)		39626 NM_001104138.2 NP_001097608.1
worm (Caenorhabditis elegans)	Secernentea	tag-141⁶	Temporarily Assigned Gene name family member (tag-...	29(a)	possible ortholog	IV(17364965-17366454)
thale cress (Arabidopsis thaliana)	eudicotyledons	IAR1⁶	IAA-alanine resistance protein 1	22(a)	1 → many	1(25521204-25524175)
rice (Oryza sativa)	Liliopsida	--	metal cation transporter, putative, expressed	20(a)	1 → many	8(22984381-22992760)

ENSEMBL Gene Tree for SLC39A10 (if available)
TreeFam Gene Tree for SLC39A10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC39A10 gene

SLC39A5² SLC39A8² SLC39A14² SLC39A4² SLC39A13² SLC39A12² SLC39A6² SLC39A7²

2 SIMAP similar genes for SLC39A10 using alignment to 7 protein entries: S39AA_HUMAN (see all proteins):

SLC39A12 SLC39A6

SLC39A10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77689586^1,2	C	--	188376471(+)	`AAACAC/TANNNN`	1	--	int¹		0	--	--	--	--
rs181029438^1,2		--	196519596(+)	`TCAGTA/CGGAAA`	1	--	us2k¹		0	--	--	--	--
rs114776890^1,2	F	--	196519602(+)	`GGAAAA/TGTAAT`	1	--	us2k¹		1		WA	118
rs61404865^1,2	C	--	196519622(+)	`GCAGAT/-GAATC`	1	--	us2k¹		2		NA CSA	4
rs201018780^1,2	C	--	196519623(+)	`GCAGAG/TANNNN`	1	--	us2k¹		0	--	--	--	--
rs115349522^1,2	F	--	196519839(+)	`AGTGAC/TTAATA`	1	--	us2k¹		1		WA	118
rs137896099^1,2		--	196519940(+)	`TGGCAC/TAGGGG`	2	--	us2k¹		0	--	--	--	--
rs186015223^1,2		--	196519954(+)	`GAAGCA/GTGGGG`	2	--	us2k¹		0	--	--	--	--
rs189341321^1,2		--	196519974(+)	`TCAGAA/GTTGCA`	2	--	us2k¹		0	--	--	--	--
rs934911^1,2	C,A,H	--	196520199(-)	`TCATAA/CTTATT`	2	--	us2k¹		12		NA WA CSA	258

HapMap Linkage Disequilibrium report for SLC39A10 (196440701 - 196602426 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC39A10
1 CNV: 58951

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC39A10

DNA2.0 Custom Variant and Variant Library Synthesis for SLC39A10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC39A10 for disorders           About GeneDecksing

OMIM gene information: 608733    OMIM disorders: --

2 diseases for SLC39A10:    About MalaCards

breast cancer prostatitis

Human Genome Epidemiology (HuGE) Navigator: SLC39A10 (2 documents)

Export disorders for SLC39A10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC39A10 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with SLC39A10)

Utopia: connect your pdf to the dynamic
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The LZT proteins; the LIV-1 subfamily of zinc transporters. (PubMed id 12659941)^{1, 3} Taylor K.M. and Nicholson R.I. (2003)
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2} Nagase T.... Ohara O. (1999)
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. (PubMed id 22832960)¹ Service S.K....Freimer N.B. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)² Daub H.... Mann M. (2008)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57181	HGNC: 20861	AceView: SLC39A10	Ensembl:ENSG00000196950	euGenes: HUgn57181
ECgene: SLC39A10	H-InvDB: SLC39A10

(According to HUGE)
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HUGE: KIAA1265

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLC39A10	Pharmacogenomics, SNPs, Pathways

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SLC39A10 Gene

solute carrier family 39 (zinc transporter), member 10

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SLC39A10 Gene

solute carrier family 39 (zinc transporter), member 10

Aliasesfor SLC39A10 gene

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