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SLC39A10 Gene

protein-coding   GIFtS: 56
GCID: GC02P196440

Solute Carrier Family 39 (Zinc Transporter), Member 10

(Previous names: solute carrier family 39 (metal ion transporter), member...)
  Search for SLC39A10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 101 2     LZT-Hs22
Solute Carrier Family 39 (Metal Ion Transporter), Member 101 2     Zinc Transporter ZIP102
Solute Carrier Family 39 Member 102 3     KIAA12653
Zrt- And Irt-Like Protein 102 3     ZIP103
ZIP-102 3     

External Ids:    HGNC: 208611   Entrez Gene: 571812   Ensembl: ENSG000001969507   OMIM: 6087335   UniProtKB: Q9ULF53   

Export aliases for SLC39A10 gene to outside databases

Previous GC identifers: GC00U912989 GC02P196724 GC02P196347 GC02P196229 GC02P188374


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC39A10 Gene:
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and
lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation.
SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and
Nicholson, 2003 (PubMed 12659941)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC39A10 Gene:
SLC39A10 (solute carrier family 39 (zinc transporter), member 10) is a protein-coding gene. GO annotations related to this gene include metal ion transmembrane transporter activity. An important paralog of this gene is SLC39A5.

UniProtKB/Swiss-Prot: S39AA_HUMAN, Q9ULF5
Function: May act as a zinc-influx transporter

Gene Wiki entry for SLC39A10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC39A10 gene promoter:
         FAC1   Sp1   HSF1short   HSF1 (long)   Lmo2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC39A10 promoter sequence
   Search Chromatin IP Primers for SLC39A10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC39A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.3   Ensembl cytogenetic band:  2q32.3   HGNC cytogenetic band: 2q33.1

SLC39A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P196440:  view genomic region     (about GC identifiers)

Start:
196,440,701 bp from pter      End:
196,602,426 bp from pter
Size:
161,726 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S39AA_HUMAN, Q9ULF5 (See protein sequence)
Recommended Name: Zinc transporter ZIP10 precursor  
Size: 831 amino acids; 94132 Da
Miscellaneous: High levels of expression are correlated with invasiveness in several breast cancer lines
Sequence caution: Sequence=BAA86579.1; Type=Erroneous initiation; Sequence=CAB43393.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: A8K5C6 Q3MJA4 Q68CR5 Q6DKH6 Q9Y3Z1

Explore the universe of human proteins at neXtProt for SLC39A10: NX_Q9ULF5

Explore proteomics data for SLC39A10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys50, Lys66, Lys533
  • Glycosylation2 at Asn139, Asn198, Ser210, Asn218, Thr248, Asn339
  • Modification sites at PhosphoSitePlus

  • See SLC39A10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001120729.1  NP_065075.1  

    ENSEMBL proteins: 
     ENSP00000389640   ENSP00000386766   ENSP00000394469   ENSP00000352655   ENSP00000394995  
     ENSP00000406590   ENSP00000409272   ENSP00000437787  
    Reactome Protein details: Q9ULF5

    SLC39A10 Human Recombinant Protein Products:

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    OriGene Custom Protein Services for SLC39A10
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    Novus Biologicals SLC39A10 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC39A10

     
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    ThermoFisher Antibodies for SLC39A10
    LSBio Antibodies in human, mouse, rat for SLC39A10

    SLC39A10 Assay Products:

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    Cloud-Clone Corp. ELISAs for SLC39A10
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    Search eBioscience for ELISAs for SLC39A10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 10
    SLC39 family of metal ion transporters

    1 InterPro protein domain:
     IPR003689 ZIP

    Graphical View of Domain Structure for InterPro Entry Q9ULF5

    ProtoNet protein and cluster: Q9ULF5

    1 Blocks protein domain: IPB003689 Zinc transporter ZIP

    UniProtKB/Swiss-Prot: S39AA_HUMAN, Q9ULF5
    Similarity: Belongs to the ZIP transporter (TC 2.A.5) family


    Find genes that share domains with SLC39A10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S39AA_HUMAN, Q9ULF5
    Function: May act as a zinc-influx transporter

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046873metal ion transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC39A10           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC39A10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC39A10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC39A10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC39A10

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC39A10:
    hsa-mir-186-5p (MIRT021091), hsa-mir-140-3p (MIRT021679), hsa-mir-103a-3p (MIRT027001), hsa-mir-155-5p (MIRT005099), hsa-mir-16-5p (MIRT031516), hsa-mir-324-5p (MIRT043081)

    Block miRNA regulation of human, mouse, rat SLC39A10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC39A10 (see all 97):
    hsa-miR-323-3p hsa-miR-300 hsa-miR-15a hsa-miR-199a-3p hsa-miR-128 hsa-miR-219-5p hsa-miR-30d hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidSLC39A10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC39A10
    Predesigned siRNA for gene silencing in human, mouse, rat SLC39A10

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for SLC39A10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC39A10 (NM_020342)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC39A10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC39A10

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC39A10 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S39AA_HUMAN, Q9ULF5: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC39A10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC39A10 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    2Metal ion SLC transporters
    Metal ion SLC transporters
    Zinc influx into cells by the SLC39 gene family0.00
    Zinc transporters0.00


    Find genes that share SuperPaths with SLC39A10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC39A10
        Zinc influx into cells by the SLC39 gene family


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC39A10
    Interactions:

        Search GeneGlobe Interaction Network for SLC39A10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for SLC39A10 (Q9ULF53 ENSP000003526554) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETS1P149213, ENSP000003764364I2D: score=1 STRING: ENSP00000376436
    NAPGQ997473I2D: score=5 
    CLN3Q132863I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    ETS2ENSP000003533444STRING: ENSP00000353344
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006829zinc ion transport IEA--
    GO:0030001metal ion transport ----
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLC39A10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC39A10 (S39AA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC39A10 gene (2 alternative transcripts): 
    NM_001127257.1  NM_020342.2  

    Unigene Cluster for SLC39A10:

    Solute carrier family 39 (zinc transporter), member 10
    Hs.650158  [show with all ESTs]
    Unigene Representative Sequence: NM_001127257
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458054 ENST00000409086(uc002utg.4) ENST00000444421 ENST00000359634(uc002uth.4)
    ENST00000430412(uc010zgp.2) ENST00000412905 ENST00000464301 ENST00000418005
    ENST00000465851 ENST00000541054
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC39A10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC39A10 (see all 97):
    hsa-miR-323-3p hsa-miR-300 hsa-miR-15a hsa-miR-199a-3p hsa-miR-128 hsa-miR-219-5p hsa-miR-30d hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidSLC39A10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC39A10
    Predesigned siRNA for gene silencing in human, mouse, rat SLC39A10
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC39A10 (see all 13)
    OriGene ORF clones in mouse, rat for SLC39A10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC39A10 (NM_020342)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC39A10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC39A10
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SLC39A10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC39A10
      QuantiTect SYBR Green Assays in human, mouse, rat SLC39A10
      QuantiFast Probe-based Assays in human, mouse, rat SLC39A10

    Additional mRNA sequence: 

    AB033091.1 AK074996.1 AK291241.1 AK294771.1 AL050294.1 BC010371.1 BC029413.1 BC047493.1 
    BC073909.1 BC101516.1 BC112223.1 CR749813.1 

    11 DOTS entries:

    DT.113693  DT.91753387  DT.121030412  DT.213677  DT.75184258  DT.121030387  DT.95260424  DT.99990819 
    DT.91753390  DT.95177423  DT.95275242 

    Selected AceView cDNA sequences (see all 170):

    AB033091 H18696 AL042656 N99716 AW872826 AA282932 BM904169 AW874409 
    AI580405 BX489404 AA283096 AV705100 CR599732 AA491292 AA371057 BI597376 
    AA191514 BM556605 BM997974 AI699181 AI679751 BC047493 AW444556 CA841010 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC39A10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCCTTAT
    SLC39A10 Expression
    About this image


    SLC39A10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)
             Ovarian Somatic Cells Ovigerous Cord
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
    SLC39A10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC39A10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.650158
        Custom PCR Arrays for SLC39A10
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC39A10
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    QuantiFast Probe-based Assays in human, mouse, rat SLC39A10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC39A10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC39A10 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc39a101 , 5 solute carrier family 39 (zinc transporter), member more1, 5 86.6(n)1
    87.36(a)1
      1 (24.07 cM)5
    2270591  NM_172653.21  NP_766241.21 
     468075445 
    chicken
    (Gallus gallus)
    Aves SLC39A101 solute carrier family 39 (zinc transporter), member more 74.18(n)
    71.15(a)
      429005  XM_426562.4  XP_426562.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC39A106
    solute carrier family 39 (zinc transporter), membe...
    69(a)
    1 ↔ 1
    GL343280.1(1106064-1135283)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.90232 Transcribed sequence with weak similarity to protein more 82.45(n)    CF783212.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635522 hypothetical protein MGC63552 73.55(n)   393644  BC058056.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta foi6
    fear-of-intimacy
    29(a)
    1 → many
    3L(8518344-8527084)


    ENSEMBL Gene Tree for SLC39A10 (if available)
    TreeFam Gene Tree for SLC39A10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC39A10 gene
    SLC39A52  SLC39A82  SLC39A62  SLC39A122  SLC39A42  SLC39A142  SLC39A132  SLC39A72  
    2 SIMAP similar genes for SLC39A10 using alignment to 7 protein entries:     S39AA_HUMAN (see all proteins):
    SLC39A12    SLC39A6

    Find genes that share paralogs with SLC39A10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC39A10 (see all 1451)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1810294381,2
    C--196519596(+) TCAGTA/CGGAAA 1 -- us2k10--------
    rs1147768901,2
    C,F--196519602(+) GGAAAA/TGTAAT 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs673727031,2
    C--196519623(+) CAGAG-/TAATCA 1 -- us2k10--------
    rs2010187801,2
    C--196519623(+) GCAGAG/TANNNN 1 -- us2k10--------
    rs1153495221,2
    F--196519839(+) AGTGAC/TTAATA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1378960991,2
    --196519940(+) TGGCAC/TAGGGG 2 -- us2k10--------
    rs1860152231,2
    --196519954(+) GAAGCA/GTGGGG 2 -- us2k10--------
    rs1893413211,2
    --196519974(+) TCAGAA/GTTGCA 2 -- us2k10--------
    rs9349111,2
    C,A,H--196520199(-) TCATAA/CTTATT 2 -- us2k112Minor allele frequency- C:0.00NA WA CSA 258
    rs763758501,2
    --196520412(+) GACTCA/GGGCTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC39A10 (196440701 - 196602426 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLC39A10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875688CNV Loss21882294
    nsv515614CNV Loss19592680
    nsv834503CNV Loss17160897
    nsv3094CNV Loss18451855
    nsv820131CNV Loss19587683
    nsv834501CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608733    OMIM disorders: --


    Find genes that share disorders with SLC39A10           About GenesLikeMe

    Genetic Association Database (GAD): SLC39A10
    Human Genome Epidemiology (HuGE) Navigator: SLC39A10 (2 documents)

    Export disorders for SLC39A10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC39A10 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with SLC39A10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    3. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PubMed id 12659941)1, 3 Taylor K.M. and Nicholson R.I. (Biochim. Biophys. Acta 2003)
    4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. (PubMed id 22832960)1 Service S.K....Freimer N.B. (Transl Psychiatry 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57181 HGNC: 20861 AceView: SLC39A10 Ensembl:ENSG00000196950 euGenes: HUgn57181
    ECgene: SLC39A10 H-InvDB: SLC39A10

    (According to HUGE)
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    HUGE: KIAA1265

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC39A10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC39A10 gene:
    Search GeneIP for patents involving SLC39A10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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