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Aliases for SLC39A10 Gene

Aliases for SLC39A10 Gene

  • Solute Carrier Family 39 (Zinc Transporter), Member 10 2 3
  • Solute Carrier Family 39 (Metal Ion Transporter), Member 10 2 3
  • Solute Carrier Family 39 Member 10 3 4
  • Zrt- And Irt-Like Protein 10 3 4
  • ZIP-10 3 4
  • Zinc Transporter ZIP10 3
  • KIAA1265 4
  • LZT-Hs2 3
  • ZIP10 4

External Ids for SLC39A10 Gene

Previous GeneCards Identifiers for SLC39A10 Gene

  • GC00U912989
  • GC02P196724
  • GC02P196347
  • GC02P196229
  • GC02P196440
  • GC02P188374

Summaries for SLC39A10 Gene

Entrez Gene Summary for SLC39A10 Gene

  • Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC39A10 Gene

SLC39A10 (Solute Carrier Family 39 (Zinc Transporter), Member 10) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include metal ion transmembrane transporter activity. An important paralog of this gene is SLC39A12.

UniProtKB/Swiss-Prot for SLC39A10 Gene

  • May act as a zinc-influx transporter.

Gene Wiki entry for SLC39A10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A10 Gene

Genomics for SLC39A10 Gene

Regulatory Elements for SLC39A10 Gene

Genomic Location for SLC39A10 Gene

Start:
195,575,977 bp from pter
End:
195,737,702 bp from pter
Size:
161,726 bases
Orientation:
Plus strand

Genomic View for SLC39A10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC39A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A10 Gene

Proteins for SLC39A10 Gene

  • Protein details for SLC39A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULF5-S39AA_HUMAN
    Recommended name:
    Zinc transporter ZIP10
    Protein Accession:
    Q9ULF5
    Secondary Accessions:
    • A8K5C6
    • B4DGU0
    • Q3MJA4
    • Q68CR5
    • Q6DKH6
    • Q9Y3Z1

    Protein attributes for SLC39A10 Gene

    Size:
    831 amino acids
    Molecular mass:
    94132 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • High levels of expression are correlated with invasiveness in several breast cancer lines
    SequenceCaution:
    • Sequence=BAA86579.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43393.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC39A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A10 Gene

Proteomics data for SLC39A10 Gene at MOPED

Post-translational modifications for SLC39A10 Gene

  • Ubiquitination at Lys50, Lys66, and Lys533
  • Glycosylation at Asn139, Asn198, Ser210, Asn218, Thr248, and Asn339
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC39A10 Gene

No data available for DME Specific Peptides for SLC39A10 Gene

Domains for SLC39A10 Gene

Gene Families for SLC39A10 Gene

Protein Domains for SLC39A10 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9ULF5

UniProtKB/Swiss-Prot:

S39AA_HUMAN :
  • Q9ULF5
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A10: view

Function for SLC39A10 Gene

Molecular function for SLC39A10 Gene

UniProtKB/Swiss-Prot Function: May act as a zinc-influx transporter.

Gene Ontology (GO) - Molecular Function for SLC39A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A10: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC39A10 Gene

Localization for SLC39A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC39A10 Gene COMPARTMENTS Subcellular localization image for SLC39A10 gene
Compartment Confidence
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC39A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC39A10: view

Pathways for SLC39A10 Gene

genes like me logo Genes that share pathways with SLC39A10: view

Interacting Proteins for SLC39A10 Gene

Gene Ontology (GO) - Biological Process for SLC39A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006829 zinc II ion transport IEA --
GO:0030001 metal ion transport --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC39A10: view

Transcripts for SLC39A10 Gene

Unigene Clusters for SLC39A10 Gene

Solute carrier family 39 (zinc transporter), member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A10 Gene

No ASD Table

Relevant External Links for SLC39A10 Gene

GeneLoc Exon Structure for
SLC39A10
ECgene alternative splicing isoforms for
SLC39A10

Expression for SLC39A10 Gene

mRNA expression in normal human tissues for SLC39A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC39A10 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.9) and Brain - Anterior cingulate cortex (BA24) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC39A10 Gene

SOURCE GeneReport for Unigene cluster for SLC39A10 Gene Hs.650158

genes like me logo Genes that share expressions with SLC39A10: view

No data available for mRNA Expression by UniProt/SwissProt for SLC39A10 Gene

Orthologs for SLC39A10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC39A10 35
  • 99.8 (n)
  • 99.76 (a)
SLC39A10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC39A10 35
  • 93.94 (n)
  • 92.54 (a)
SLC39A10 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC39A10 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc39a10 35
  • 86.6 (n)
  • 87.36 (a)
Slc39a10 16
Slc39a10 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC39A10 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc39a10 35
  • 85.56 (n)
  • 87.12 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 67 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
SLC39A10 35
  • 74.18 (n)
  • 71.15 (a)
lizard
(Anolis carolinensis)
Reptilia SLC39A10 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493171 35
  • 64.8 (n)
  • 61.24 (a)
Str.9023 35
zebrafish
(Danio rerio)
Actinopterygii slc39a10 35
  • 62.08 (n)
  • 61.46 (a)
slc39a10 36
  • 46 (a)
OneToOne
zgc63552 35
fruit fly
(Drosophila melanogaster)
Insecta foi 36
  • 29 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.192 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for SLC39A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC39A10 Gene

ENSEMBL:
Gene Tree for SLC39A10 (if available)
TreeFam:
Gene Tree for SLC39A10 (if available)

Paralogs for SLC39A10 Gene

Selected SIMAP similar genes for SLC39A10 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC39A10: view

Variants for SLC39A10 Gene

Sequence variations from dbSNP and Humsavar for SLC39A10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2486 -- 195,658,161(+) CTCTC(C/T)TGGGG intron-variant
rs7014 -- 195,660,680(+) GAATT(C/T)TGGGT intron-variant
rs13489 -- 195,660,613(+) TGGAC(A/G)TAAGT intron-variant
rs747627 -- 195,673,331(+) ttttt(C/T)gtatt intron-variant
rs842735 -- 195,717,463(+) TTAAA(A/G)GGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A10 Gene

Variant ID Type Subtype PubMed ID
nsv834501 CNV Gain 17160897
nsv515614 CNV Loss 19592680
nsv834503 CNV Loss 17160897
nsv820131 CNV Loss 19587683
nsv875688 CNV Loss 21882294
nsv3094 CNV Loss 18451855

Relevant External Links for SLC39A10 Gene

HapMap Linkage Disequilibrium report
SLC39A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A10 Gene

Disorders for SLC39A10 Gene

Relevant External Links for SLC39A10

Genetic Association Database (GAD)
SLC39A10
Human Genome Epidemiology (HuGE) Navigator
SLC39A10
genes like me logo Genes that share disorders with SLC39A10: view

No data available for UniProtKB/Swiss-Prot for SLC39A10 Gene

Publications for SLC39A10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  3. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PMID: 12659941) Taylor K.M. … Nicholson R.I. (Biochim. Biophys. Acta 2003) 2 3
  4. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 48
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for SLC39A10 Gene

Sources for SLC39A10 Gene

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