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Aliases for SLC39A1 Gene

Aliases for SLC39A1 Gene

  • Solute Carrier Family 39 (Zinc Transporter), Member 1 2 3
  • ZIRTL 3 4 6
  • Zrt- And Irt-Like Protein 1 3 4
  • ZIP1 3 4
  • Solute Carrier Family 39 (Zinc Transporter), Member 3 3
  • Zinc/Iron Regulated Transporter-Like 2
  • Zinc-Iron-Regulated Transporter-Like 4
  • Solute Carrier Family 39 Member 1 4
  • Zinc Transporter ZIP1 3
  • ZIP-1 4
  • HZIP1 4
  • IRT1 4

External Ids for SLC39A1 Gene

Previous HGNC Symbols for SLC39A1 Gene

  • ZIRTL

Previous GeneCards Identifiers for SLC39A1 Gene

  • GC01M151748
  • GC01M149662
  • GC01M150706
  • GC01M151148
  • GC01M150744
  • GC01M152198
  • GC01M125294

Summaries for SLC39A1 Gene

Entrez Gene Summary for SLC39A1 Gene

  • This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for SLC39A1 Gene

SLC39A1 (Solute Carrier Family 39 (Zinc Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC39A1 include acrodermatitis enteropathica and enteropathica. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include receptor binding and inorganic cation transmembrane transporter activity. An important paralog of this gene is SLC39A3.

UniProtKB/Swiss-Prot for SLC39A1 Gene

  • Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.

Gene Wiki entry for SLC39A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A1 Gene

Genomics for SLC39A1 Gene

Regulatory Elements for SLC39A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC39A1 Gene

Start:
153,959,099 bp from pter
End:
153,968,184 bp from pter
Size:
9,086 bases
Orientation:
Minus strand

Genomic View for SLC39A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC39A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A1 Gene

Proteins for SLC39A1 Gene

  • Protein details for SLC39A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY26-S39A1_HUMAN
    Recommended name:
    Zinc transporter ZIP1
    Protein Accession:
    Q9NY26
    Secondary Accessions:
    • B4DDY7
    • Q5T4K1
    • Q8N2H7
    • Q9BTV0
    • Q9UBI7
    • Q9Y2Z7
    • Q9Y380

    Protein attributes for SLC39A1 Gene

    Size:
    324 amino acids
    Molecular mass:
    34250 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Inhibited by Ni(2+) ions. Fe(2+) ions do not inhibit zinc uptake
    SequenceCaution:
    • Sequence=AAD27717.1; Type=Frameshift; Positions=16, 40; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC39A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A1 Gene

Proteomics data for SLC39A1 Gene at MOPED

Post-translational modifications for SLC39A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SLC39A1 Gene

Domains for SLC39A1 Gene

Gene Families for SLC39A1 Gene

Protein Domains for SLC39A1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NY26

UniProtKB/Swiss-Prot:

S39A1_HUMAN :
  • Q9NY26
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A1: view

Function for SLC39A1 Gene

Molecular function for SLC39A1 Gene

UniProtKB/Swiss-Prot Function: Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.

Gene Ontology (GO) - Molecular Function for SLC39A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005385 zinc ion transmembrane transporter activity IEA --
GO:0022890 inorganic cation transmembrane transporter activity TAS 10610721
GO:0046873 metal ion transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC39A1: view

Phenotypes for SLC39A1 Gene

genes like me logo Genes that share phenotypes with SLC39A1: view

Animal Model Products

CRISPR Products

miRNA for SLC39A1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC39A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC39A1 Gene

Localization for SLC39A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A1 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC39A1 Gene COMPARTMENTS Subcellular localization image for SLC39A1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC39A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 10610721
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC39A1: view

Pathways for SLC39A1 Gene

genes like me logo Genes that share pathways with SLC39A1: view

Gene Ontology (GO) - Biological Process for SLC39A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport TAS 10610721
GO:0006829 zinc II ion transport --
GO:0030001 metal ion transport --
GO:0055085 transmembrane transport TAS --
GO:0071577 zinc II ion transmembrane transport IMP 11301334
genes like me logo Genes that share ontologies with SLC39A1: view

Compounds for SLC39A1 Gene

(3) Novoseek inferred chemical compound relationships for SLC39A1 Gene

Compound -log(P) Hits PubMed IDs
zinc 67.9 34
iron 31.7 9
cadmium 24.9 1
genes like me logo Genes that share compounds with SLC39A1: view

Transcripts for SLC39A1 Gene

Unigene Clusters for SLC39A1 Gene

Solute carrier family 39 (zinc transporter), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC39A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - -
SP9: -
SP10:

ExUns: 9h
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for SLC39A1 Gene

GeneLoc Exon Structure for
SLC39A1
ECgene alternative splicing isoforms for
SLC39A1

Expression for SLC39A1 Gene

mRNA expression in normal human tissues for SLC39A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC39A1 Gene

SOURCE GeneReport for Unigene cluster for SLC39A1 Gene Hs.7854

mRNA Expression by UniProt/SwissProt for SLC39A1 Gene

Q9NY26-S39A1_HUMAN
Tissue specificity: Ubiquitous. Expressed in most adult and fetal tissues including the epidermis.
genes like me logo Genes that share expressions with SLC39A1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC39A1 Gene

Orthologs for SLC39A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC39A1 35
  • 99.59 (n)
  • 99.69 (a)
SLC39A1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC39A1 35
  • 89.71 (n)
  • 94.44 (a)
SLC39A1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC39A1 35
  • 89.92 (n)
  • 95.68 (a)
SLC39A1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc39a1 35
  • 86.93 (n)
  • 93.83 (a)
Slc39a1 16
Slc39a1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC39A1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc39a1 35
  • 86.83 (n)
  • 94.14 (a)
lizard
(Anolis carolinensis)
Reptilia SLC39A1 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a1 35
  • 61.44 (n)
  • 52.94 (a)
Str.7666 35
zebrafish
(Danio rerio)
Actinopterygii slc39a3 36
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9430 36
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F31C3.4 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
ManyToMany
Species with no ortholog for SLC39A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A1 Gene

ENSEMBL:
Gene Tree for SLC39A1 (if available)
TreeFam:
Gene Tree for SLC39A1 (if available)

Paralogs for SLC39A1 Gene

Paralogs for SLC39A1 Gene

Selected SIMAP similar genes for SLC39A1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SLC39A1 Gene

genes like me logo Genes that share paralogs with SLC39A1: view

Variants for SLC39A1 Gene

Sequence variations from dbSNP and Humsavar for SLC39A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2280966 -- 153,960,799(-) GCATC(G/T)CACTC intron-variant
rs3791186 -- 153,961,827(-) TTGCT(A/G)ACCTT intron-variant
rs3791187 -- 153,961,727(-) TGGAT(A/G)GTGGG intron-variant
rs7526227 -- 153,965,037(+) TATAG(G/T)TGTCA upstream-variant-2KB, intron-variant
rs11264734 -- 153,965,270(+) aaaaa(C/T)acaaa upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A1 Gene

Variant ID Type Subtype PubMed ID
nsv872450 CNV Loss 21882294

Relevant External Links for SLC39A1 Gene

HapMap Linkage Disequilibrium report
SLC39A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A1 Gene

Disorders for SLC39A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (5) Diseases for SLC39A1 Gene including...

Search for SLC39A1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SLC39A1 Gene

(5) Novoseek inferred disease relationships for SLC39A1 Gene

Disease -log(P) Hits PubMed IDs
zinc deficiency 64.1 1
erythroleukemia 49.3 1
iron deficiency 39.1 1
prostate cancer 38.6 4
tumors 0 3

Relevant External Links for SLC39A1

Genetic Association Database (GAD)
SLC39A1
genes like me logo Genes that share disorders with SLC39A1: view

No data available for UniProtKB/Swiss-Prot for SLC39A1 Gene

Publications for SLC39A1 Gene

  1. Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex. (PMID: 10610721) Lioumi M. … Ragoussis J. (Genomics 1999) 2 3 4 23
  2. The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. (PMID: 11301334) Gaither L.A. … Eide D.J. (J. Biol. Chem. 2001) 3 4 23
  3. Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. (PMID: 10477520) Gong J. … Li M. (Science 1999) 3 23
  4. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. (PMID: 14525987) Dufner-Beattie J. … Andrews G.K. (J. Biol. Chem. 2003) 3 23
  5. Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells. (PMID: 16203195) Tang Z. … Gupta A. (Bone 2006) 3 23

Products for SLC39A1 Gene

  • antibodies-online peptides for SLC39A1
  • antibodies-online antibodies for SLC39A1
  • antibodies-online kits for SLC39A1

Sources for SLC39A1 Gene

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