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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC39A1 Gene

protein-coding   GIFtS: 56
GCID: GC01M153931

Solute Carrier Family 39 (Zinc Transporter), Member 1

(Previous name: zinc/iron regulated transporter-like)
(Previous symbol: ZIRTL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 39 (Zinc Transporter), Member 11 2     Zinc Transporter ZIP12
ZIRTL1 2 3 5     IRT13
Zrt- And Irt-Like Protein 12 3     ZIP-13
ZIP12 3     hZIP13
Zinc/Iron Regulated Transporter-Like1     Solute Carrier Family 39 Member 13
Solute Carrier Family 39 (Zinc Transporter), Member 32     Zinc-Iron-Regulated Transporter-Like3

External Ids:    HGNC: 128761   Entrez Gene: 271732   Ensembl: ENSG000001435707   OMIM: 6047405   UniProtKB: Q9NY263   

Export aliases for SLC39A1 gene to outside databases

Previous GC identifers: GC01M151748 GC01M149662 GC01M150706 GC01M151148 GC01M150744 GC01M152198 GC01M125294


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC39A1 Gene:
This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane
and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and
Alzheimer's disease. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2012)

GeneCards Summary for SLC39A1 Gene: 
SLC39A1 (solute carrier family 39 (zinc transporter), member 1) is a protein-coding gene. Diseases associated with SLC39A1 include acrodermatitis, and enteropathica, and among its related super-pathways are Zinc transporters and Transmembrane transport of small molecules. GO annotations related to this gene include inorganic cation transmembrane transporter activity and receptor binding. An important paralog of this gene is SLC39A3.

UniProtKB/Swiss-Prot: S39A1_HUMAN, Q9NY26
Function: Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the
body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells

Gene Wiki entry for SLC39A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC39A1 gene promoter:
         Tal-1beta   CREB   PPAR-gamma1   POU2F1   POU2F1a   deltaCREB   PPAR-gamma2   ITF-2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC39A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC39A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC39A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

SLC39A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC39A1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153931:  view genomic region     (about GC identifiers)

Start:
153,931,575 bp from pter      End:
153,940,188 bp from pter
Size:
8,614 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S39A1_HUMAN, Q9NY26 (See protein sequence)
Recommended Name: Zinc transporter ZIP1  
Size: 324 amino acids; 34250 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass
membrane protein. Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in
several epithelial cell lines
Miscellaneous: Inhibited by Ni(2+) ions. Fe(2+) ions do not inhibit zinc uptake
Sequence caution: Sequence=AAD27717.1; Type=Frameshift; Positions=16, 40;
Secondary accessions: Q5T4K1 Q8N2H7 Q9BTV0 Q9UBI7 Q9Y2Z7 Q9Y380

Explore the universe of human proteins at neXtProt for SLC39A1: NX_Q9NY26

Explore proteomics data for SLC39A1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NY26

  • SLC39A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC39A1 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001258886.1  NP_001258887.1  NP_001258888.1  NP_001258889.1  NP_001258890.1  NP_055252.2  

    ENSEMBL proteins: 
     ENSP00000348535   ENSP00000357612   ENSP00000357610   ENSP00000309710   ENSP00000392950  
     ENSP00000392229   ENSP00000407717   ENSP00000443632  
    Reactome Protein details: Q9NY26
    Human Recombinant Protein Products for SLC39A1: 
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    Novus Biologicals SLC39A1 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS10610721
    GO:0016021integral to membrane IEA--

    SLC39A1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 1 
    SLC39 family of metal ion transporters

    1 InterPro protein domain:
     IPR003689 ZIP

    Graphical View of Domain Structure for InterPro Entry Q9NY26

    ProtoNet protein and cluster: Q9NY26

    1 Blocks protein domain: IPB003689 Zinc transporter ZIP

    UniProtKB/Swiss-Prot: S39A1_HUMAN, Q9NY26
    Similarity: Belongs to the ZIP transporter (TC 2.A.5) family


    SLC39A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S39A1_HUMAN, Q9NY26
    Function: Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the
    body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0005385zinc ion transmembrane transporter activity IEA--
    GO:0022890inorganic cation transmembrane transporter activity TAS10610721
    GO:0046873metal ion transmembrane transporter activity ----
         
    SLC39A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC39A1:
     Increased G1 DNA content 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc39a1):
     craniofacial  embryogenesis  growth/size  integument  limbs/digits/tail 

    SLC39A1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC39A1 
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    hsa-miR-146a hsa-miR-1271 hsa-miR-218 hsa-miR-223 hsa-miR-133a hsa-miR-4274 hsa-miR-376a* hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidSLC39A1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC39A1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Zinc transporters
    Zinc transporters0.68
    Zinc influx into cells by the SLC39 gene family0.59
    Metal ion SLC transporters0.68
    2SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    3Senescence and Autophagy
    Senescence and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SLC39A1
        Senescence and Autophagy

    5/6        Reactome Pathways for SLC39A1 (see all 6)
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Metal ion SLC transporters
    Zinc transporters



    SLC39A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC39A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for SLC39A1 (Q9NY263 ENSP000003097104) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLEKHM2Q8IWE53, ENSP000003649564I2D: score=3 STRING: ENSP00000364956
    KCNAB1Q147223, ENSP000004199524I2D: score=1 STRING: ENSP00000419952
    PRKCZQ055133, ENSP000003678304I2D: score=1 STRING: ENSP00000367830
    SLC39A2Q9NP943, ENSP000002986814I2D: score=1 STRING: ENSP00000298681
    KCNAB2Q133033, ENSP000001642474I2D: score=1 STRING: ENSP00000164247
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport TAS10610721
    GO:0006829zinc ion transport ----
    GO:0030001metal ion transport ----
    GO:0055085transmembrane transport TAS--
    GO:0071577zinc ion transmembrane transport IMP11301334

    SLC39A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC39A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC39A1 (S39A1)

    3 Novoseek inferred chemical compound relationships for SLC39A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 67.9 53 16153295 (6), 11301334 (4), 17550612 (4), 14525987 (2) (see all 15)
    iron 31.7 11 12805609 (4), 14526117 (4), 18397377 (1)
    cadmium 24.9 1 14526117 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC39A1 / S39A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC39A1 gene (6 alternative transcripts): 
    NM_001271957.1  NM_001271958.1  NM_001271959.1  NM_001271960.1  NM_001271961.1  NM_014437.4  

    Unigene Cluster for SLC39A1:

    Solute carrier family 39 (zinc transporter), member 1
    Hs.7854  [show with all ESTs]
    Unigene Representative Sequence: BC047288
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356205(uc001fdk.3 uc010pee.2) ENST00000368623(uc001fdj.3)
    ENST00000368621(uc001fdi.3) ENST00000310483(uc001fdl.3) ENST00000429040
    ENST00000413622 ENST00000417348 ENST00000461071 ENST00000537590
    miRNA
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    hsa-miR-146a hsa-miR-1271 hsa-miR-218 hsa-miR-223 hsa-miR-133a hsa-miR-4274 hsa-miR-376a* hsa-miR-3121-3p
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    Additional mRNA sequence: 

    AF132942.1 AF151829.1 AJ243649.1 AJ271671.1 AK074943.1 AK075257.1 AK293389.1 AK297983.1 
    AK300244.1 BC002563.2 BC003152.2 BC007886.2 BC014303.2 BC047288.1 BC069261.1 CR457217.1 

    24/48 DOTS entries (see all 48):

    DT.92452611  DT.99950147  DT.100804939  DT.100670050  DT.100670043  DT.95070646  DT.100670055  DT.100670051 
    DT.95070643  DT.121436483  DT.121436419  DT.100670047  DT.100876689  DT.121436521  DT.91935800  DT.100670049 
    DT.92452610  DT.100804343  DT.121436477  DT.121436480  DT.92452619  DT.100835652  DT.100846585  DT.100670045 

    24/822 AceView cDNA sequences (see all 822):

    CA389458 BX384222 BQ219490 BX377691 BG680742 BC069261 BG752491 AW467553 
    BI753823 CD721940 BM754491 AF289574 AW675147 BQ010207 CR605081 CR615763 
    AA922287 BQ067116 BU625598 BM987537 BM468736 R99649 BG319572 BF725851 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A1 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ·
    SP1:                                -     -     -     -     -     -     -     -     -     -                                                                     
    SP2:                    -           -     -     -     -     -     -     -     -     -     -                                                                     
    SP3:        -     -     -           -     -     -     -     -     -     -     -     -     -                                                                     
    SP4:                                            -     -     -     -     -     -     -     -                                                                     
    SP5:                                                  -     -     -     -     -     -     -                                                                     

    ExUns: 9h
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SLC39A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC39A1 expression in normal human tissues (normalized intensities)      SLC39A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAGATGAT
    SLC39A1 Expression
    About this image


    SLC39A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             spinal cord/lateral wall/ventricular layer   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Thymus (Hematopoietic System)
             Thymus

    See SLC39A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC39A1

    SOURCE GeneReport for Unigene cluster: Hs.7854

    UniProtKB/Swiss-Prot: S39A1_HUMAN, Q9NY26
    Tissue specificity: Ubiquitous. Expressed in most adult and fetal tissues including the epidermis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC39A1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc39a11 , 5 solute carrier family 39 (zinc transporter), member more1, 5 86.93(n)1
    93.83(a)1
      3 (39.21 cM)5
    307911  NM_013901.21  NP_038929.21 
     902481725 
    lizard
    (Anolis carolinensis)
    Reptilia SLC39A16
    solute carrier family 39 (zinc transporter), membe...
    43(a)
    1 ↔ 1
    AAWZ02040249(1048-3180)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU910435.12   -- 70.84(n)    BU910435.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc39a11 solute carrier family 39 (zinc transporter), member more 56.33(n)
    48.78(a)
      321324  NM_212583.2  NP_997748.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta ZIP11 Zinc/iron regulated transporter-related protein 1 46.57(n)
    34.4(a)
      35579  NM_080368.3  NP_525107.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F31C3.41 Protein F31C3.4 43.84(n)
    32.19(a)
      173376  NM_061225.5  NP_493626.1 


    ENSEMBL Gene Tree for SLC39A1 (if available)
    TreeFam Gene Tree for SLC39A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC39A1 gene
    SLC39A32  SLC39A22  
    2 SIMAP similar genes for SLC39A1 using alignment to 7 protein entries:     S39A1_HUMAN (see all proteins):
    SLC39A2    SLC39A3

    SLC39A1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC39A1
    PGOHUM00000246562


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/98 SNPs in SLC39A1 are shown (see all 98)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1408960561,2
    C,F--153933198(+) CCCATG/AGCCAG 12 /A /H /Y syn1 mis11Minor allele frequency- A:0.00NA 3678
    rs22809661,2
    C,H--153933275(-) GCATCT/GCACTC 6 -- int16Minor allele frequency- G:0.00NS EA NA 424
    rs1180920591,2
    C,F--153933426(+) GTTACG/ATGTAG 6 -- int11Minor allele frequency- A:0.01EA 120
    rs1499717791,2
    --153933585(+) TGTCTC/TTACTA 6 -- int10--------
    rs1866161481,2
    --153933756(+) CAAAAA/GCAAAA 6 -- int10--------
    rs1452007621,2
    --153933789(+) AAACAC/TTTTGG 6 -- int10--------
    rs757509251,2
    F--153933946(+) CATTAC/GCAAAT 6 -- int11Minor allele frequency- G:0.02EA 120
    rs1491499221,2
    --153934008(+) ATACAC/TGAAAA 6 -- int10--------
    rs1450413941,2
    --153934085(+) TATACA/GCAGTC 6 -- int10--------
    rs37911871,2
    C,F,A,H--153934203(-) TGGATA/GGTGGG 6 -- int122Minor allele frequency- G:0.25EA NS NA CSA WA 3850

    HapMap Linkage Disequilibrium report for SLC39A1 (153931575 - 153940188 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLC39A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv872450CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604740    OMIM disorders: --

    10 diseases for SLC39A1:    About MalaCards
    acrodermatitis    enteropathica    acrodermatitis enteropathica    prostate cancer
    hemochromatosis    prostate cancer, progression of    prostatitis    alzheimer's disease
    breast cancer    obesity

    1 disease from the University of Copenhagen DISEASES database for SLC39A1:
    Acrodermatitis enteropathica

    SLC39A1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for SLC39A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc deficiency 64.1 1 9618566 (1)
    erythroleukemia 49.3 1 11301334 (1)
    iron deficiency 39.1 1 14526117 (1)
    prostate cancer 38.6 6 17400177 (2), 16153295 (2)
    tumors 0 4 17400177 (1), 16700911 (1), 17550612 (1)

    Genetic Association Database (GAD): SLC39A1

    Export disorders for SLC39A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC39A1 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with SLC39A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex. (PubMed id 10610721)1, 2, 3, 9 Lioumi M.... Ragoussis J. (1999)
    2. The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. (PubMed id 11301334)1, 2, 9 Gaither L.A. and Eide D.J. (2001)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells. (PubMed id 12888280)1, 2 Franklin R.B....Costello L.C. (2003)
    7. Differential subcellular localization of hZip1 in adherent and non- adherent cells. (PubMed id 11696349)1, 2 Milon B.... Beaumont C. (2001)
    8. Functional expression of the human hZIP2 zinc transporter. (PubMed id 10681536)1, 3 Gaither L.A. and Eide D.J. (2000)
    9. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    10. A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein. (PubMed id 17635580)1, 9 Huang L. and Kirschke C.P. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27173 HGNC: 12876 AceView: SLC39A1andTORC2 Ensembl:ENSG00000143570 euGenes: HUgn27173
    ECgene: SLC39A1 H-InvDB: SLC39A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC39A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC39A1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC39A1 gene:
    Search GeneIP for patents involving SLC39A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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