SLC38A9 Gene
protein-coding GIFtS: 44
GCID: GC05M054958
|
|
Solute Carrier Family 38, Member 9
| |
Aliases
for SLC38A9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 38, Member 91 2 | | Putative Sodium-Coupled Neutral Amino Acid Transporter 92 | | Solute Carrier Family 38 Member 92 |
Export aliases for SLC38A9 gene to outside databasesPrevious GC identifer: GC05M051895 |
Summaries
for SLC38A9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for SLC38A9 Gene: 
SLC38A9 (solute carrier family 38, member 9) is a protein-coding gene.
UniProtKB/Swiss-Prot: S38A9_HUMAN, Q8NBW4Function: Putative sodium-dependent amino acid/proton antiporter (By similarity)
|
Genomic Views
for SLC38A9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.2 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC38A9 gene promoter:
AhR COUP-TF1 COUP FOXO3 HNF-4alpha2 HNF-4alpha1 FOXO3b COUP-TF NRF-2 FOXO3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC38A9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC38A9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q11.2 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2SLC38A9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M054958: view genomic region
(about GC identifiers)
Start:
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54,921,673 bp from pter |
End:
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55,069,022 bp from pter |
Size:
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147,350 bases |
Orientation:
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minus strand |
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Proteins
for SLC38A9 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: S38A9_HUMAN, Q8NBW4 (See
protein sequence)Recommended Name: Putative sodium-coupled neutral amino acid transporter 9 Size: 561 amino acids; 63776 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B3KXV1 B7Z7D0 Q0P5S0 Q6MZJ8Alternative splicing: 4 isoforms: Q8NBW4-1 Q8NBW4-2 Q8NBW4-3 Q8NBW4-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC38A9: NX_Q8NBW4
Explore proteomics data for SLC38A9 at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_Q8NBW4
SLC38A9 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001245215.1 NP_001245216.1 NP_001269358.1 NP_775785.2
ENSEMBL proteins: ENSP00000427707 ENSP00000380074 ENSP00000420934 ENSP00000426925 ENSP00000427335 ENSP00000423219 ENSP00000426413 ENSP00000424918 ENSP00000425055 ENSP00000427624 ENSP00000422843 ENSP00000424271 ENSP00000425259 ENSP00000420950 ENSP00000425842 ENSP00000316596 ENSP00000397429 ENSP00000437771
Human Recombinant Protein Products for SLC38A9:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC38A9 for ontologies About GeneDecksing
SLC38A9 Antibody Products:
Assay Products for SLC38A9: |
Protein
Domains /
Families
for SLC38A9 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| HGNC Gene Families:
SLC: Solute carriers
IUPHAR Guide to PHARMACOLOGY protein family classification: SLC38A9
Orphan SLC38 transporters
1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry Q8NBW4ProtoNet protein and cluster: Q8NBW4 UniProtKB/Swiss-Prot: S38A9_HUMAN, Q8NBW4Similarity: Belongs to the amino acid/polyamine transporter 2 family
SLC38A9 for domains About GeneDecksing
|
Function
for SLC38A9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: S38A9_HUMAN, Q8NBW4Function: Putative sodium-dependent amino acid/proton antiporter (By similarity)Phenotypes:
2 GenomeRNAi human phenotypes for SLC38A9:
Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A9 |
|
Pathways & Interactions
for SLC38A9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC38A9
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006814 | sodium ion transport |
IEA | -- | | GO:0006865 | amino acid transport |
IEA | -- |
SLC38A9 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC38A9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
IUPHAR,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC38A9 (S38A9)
1 HMDB Compound for SLC38A9 About this table
Search CenterWatch for drugs/clinical trials and news about SLC38A9 / S38A9
|
Transcripts
for SLC38A9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC38A9 gene (4 alternative transcripts): NM_001258286.1 NM_001258287.1 NM_001282429.1 NM_173514.3 Unigene Cluster for SLC38A9: Solute carrier family 38, member 9 Hs.745105 [show with all ESTs]Unigene Representative Sequence: NM_00125828618/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27): ENST00000515159 ENST00000505708(uc003jqe.2) ENST00000396865(uc003jqf.2 uc010ivy.2)
ENST00000515629(uc003jqd.2 uc010ivx.2) ENST00000508124 ENST00000512595
ENST00000511233 ENST00000515754 ENST00000524030 ENST00000512208 ENST00000524154
ENST00000507447 ENST00000514806 ENST00000503817 ENST00000503891 ENST00000502247
ENST00000513993 ENST00000505563
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for SLC38A9
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC38A9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC38A9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC38A9 |
Additional mRNA sequence: AK057666.1 AK075190.1 AK122957.1 AK127988.1 AK301850.1 BC036232.1 BC045589.1 BC066891.1 BC101361.1 BC101362.2 NR_047649.1 NR_047650.1 13 DOTS entries: DT.95150773 DT.91745257 DT.100000911 DT.100719456 DT.40113778 DT.40124443 DT.97786686 DT.100705024 DT.100754703 DT.40197539 DT.40289376 DT.99970630 DT.40221334 24/63 AceView cDNA sequences (see all 63): AI418728 AK122957 AK127988 CR608660 BX101969 AW449801 AA760716 BC036232 AW026144 BU632379 AW024248 BG722552 BG435054 BX641065 BM128969 CB961543 BI559772 CB988696 AK075190 BG054799 AI149244 AI580489 BI464442 AV734387
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A9 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
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| SP1: | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC38A9
|
Expression
for SLC38A9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC38A9 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
About this image
See SLC38A9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC38A9
SOURCE GeneReport for Unigene cluster: Hs.745105
SABiosciences Custom PCR Arrays for SLC38A9
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for SLC38A9
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC38A9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC38A9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC38A9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A9 |
Orthologs
for SLC38A9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SLC38A9 gene from 6/14 species (see all 14) About this table
ENSEMBL Gene Tree for SLC38A9 (if available)
TreeFam Gene Tree for SLC38A9 (if available) |
Paralogs
for SLC38A9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SLC38A9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC38A9 (54921673 - 55069022 bp)
Structural Variations
Database of Genomic Variants (DGV) 10/11 variations for SLC38A9 (see all 11): About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC38A9 |
|
Disorders
/ Diseases
for SLC38A9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SLC38A9 for disorders About MalaCards
SLC38A9 for disorders About GeneDecksing
Genetic Association Database (GAD): SLC38A9
Export disorders for SLC38A9 gene to outside databases
|
Publications
for SLC38A9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC38A9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC38A9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Microarray-based detection and expression analysis of ABC and SLC transporters in drug-resistant ovarian cancer cell lines. (PubMed id 23462296)1 Januchowski R....Zabel M. (2013)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC38A9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC38A9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC38A9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC38A9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC38A9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC38A9 gene:
Search GeneIP for patents involving SLC38A9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC38A9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 |
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC38A9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC38A9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC38A9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC38A9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC38A9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC38A9 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A9 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SLC38A9 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC38A9 |
| |  |  | | | | LSBio Antibodies in human, mouse, rat for SLC38A9 |
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