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Aliases for SLC38A9 Gene

Aliases for SLC38A9 Gene

  • Solute Carrier Family 38, Member 9 2 3
  • Solute Carrier Family 38 Member 9 3 4
  • Up-Regulated In Lung Cancer 11 3 4
  • URLC11 3 4
  • Putative Sodium-Coupled Neutral Amino Acid Transporter 9 3
  • Sodium-Coupled Neutral Amino Acid Transporter 9 3

External Ids for SLC38A9 Gene

Summaries for SLC38A9 Gene

GeneCards Summary for SLC38A9 Gene

SLC38A9 (Solute Carrier Family 38, Member 9) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SLC38A9 Gene

  • Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acids. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:25561175, PubMed:25567906). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids, suggesting that it acts as an amino acid sensor instead (PubMed:25561175, PubMed:25567906). The high concentration of arginine in lysosomes suggests that it acts as an arginine sensor (PubMed:25567906).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A9 Gene

Genomics for SLC38A9 Gene

Genomic Location for SLC38A9 Gene

Start:
55,625,845 bp from pter
End:
55,773,194 bp from pter
Size:
147,350 bases
Orientation:
Minus strand

Genomic View for SLC38A9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC38A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A9 Gene

Regulatory Elements for SLC38A9 Gene

Proteins for SLC38A9 Gene

  • Protein details for SLC38A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBW4-S38A9_HUMAN
    Recommended name:
    Sodium-coupled neutral amino acid transporter 9
    Protein Accession:
    Q8NBW4
    Secondary Accessions:
    • A0A0A8K8P2
    • B3KXV1
    • B7Z7D0
    • Q0P5S0
    • Q6MZJ8

    Protein attributes for SLC38A9 Gene

    Size:
    561 amino acids
    Molecular mass:
    63776 Da
    Quaternary structure:
    • Associated component of the Ragulator complex (composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5). Associated component of the Rag GTPases heterodimers (composed of RRAGA, RRAGB, RRAGC and RRAGD).
    SequenceCaution:
    • Sequence=BAQ19756.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC38A9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC38A9 Gene

Proteomics data for SLC38A9 Gene at MOPED

Post-translational modifications for SLC38A9 Gene

No data available for DME Specific Peptides for SLC38A9 Gene

Domains for SLC38A9 Gene

Gene Families for SLC38A9 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC38A9 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

S38A9_HUMAN
Domain:
  • The cytosolic N-terminus part of the protein mediates interaction with the Ragulator complex and the Rag GTPases heterodimers.:
    • Q8NBW4
Family:
  • Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.:
    • Q8NBW4
genes like me logo Genes that share domains with SLC38A9: view

Function for SLC38A9 Gene

Molecular function for SLC38A9 Gene

UniProtKB/Swiss-Prot Function: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acids. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:25561175, PubMed:25567906). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids, suggesting that it acts as an amino acid sensor instead (PubMed:25561175, PubMed:25567906). The high concentration of arginine in lysosomes suggests that it acts as an arginine sensor (PubMed:25567906).

Gene Ontology (GO) - Molecular Function for SLC38A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25561175
GO:0015171 amino acid transmembrane transporter activity IDA 25561175
genes like me logo Genes that share ontologies with SLC38A9: view

Phenotypes for SLC38A9 Gene

GenomeRNAi human phenotypes for SLC38A9:
genes like me logo Genes that share phenotypes with SLC38A9: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC38A9 Gene

Localization for SLC38A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A9 Gene

Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC38A9 Gene COMPARTMENTS Subcellular localization image for SLC38A9 gene
Compartment Confidence
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC38A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 25561175
GO:0005765 lysosomal membrane IEA --
GO:0005770 late endosome IDA 25561175
GO:0016021 integral component of membrane IEA --
GO:0071986 colocalizes_with Ragulator complex IDA 25561175
genes like me logo Genes that share ontologies with SLC38A9: view

Pathways for SLC38A9 Gene

SuperPathways for SLC38A9 Gene

No Data Available

Interacting Proteins for SLC38A9 Gene

Gene Ontology (GO) - Biological Process for SLC38A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IDA 25567906
GO:0006814 sodium ion transport --
GO:0006865 amino acid transport --
GO:0032008 positive regulation of TOR signaling IDA 25561175
GO:0071230 cellular response to amino acid stimulus IDA 25561175
genes like me logo Genes that share ontologies with SLC38A9: view

No data available for Pathways by source for SLC38A9 Gene

Compounds for SLC38A9 Gene

(1) HMDB Compounds for SLC38A9 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with SLC38A9: view

Transcripts for SLC38A9 Gene

Unigene Clusters for SLC38A9 Gene

Solute carrier family 38, member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2:
SP3:
SP4: - -

Relevant External Links for SLC38A9 Gene

GeneLoc Exon Structure for
SLC38A9
ECgene alternative splicing isoforms for
SLC38A9

Expression for SLC38A9 Gene

mRNA expression in normal human tissues for SLC38A9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC38A9 Gene

SOURCE GeneReport for Unigene cluster for SLC38A9 Gene Hs.745105

genes like me logo Genes that share expressions with SLC38A9: view

Orthologs for SLC38A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC38A9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC38A9 36
  • 99.41 (n)
  • 99.11 (a)
SLC38A9 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC38A9 36
  • 92.3 (n)
  • 91.72 (a)
SLC38A9 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC38A9 36
  • 92.77 (n)
  • 91.76 (a)
SLC38A9 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc38a9 36
  • 89.11 (n)
  • 91.43 (a)
Slc38a9 16
Slc38a9 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC38A9 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC38A9 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc38a9 36
  • 88.55 (n)
  • 91.23 (a)
chicken
(Gallus gallus)
Aves SLC38A9 36
  • 72.7 (n)
  • 72.94 (a)
SLC38A9 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC38A9 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2883 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc38a9 36
  • 68.48 (n)
  • 72.37 (a)
zebrafish
(Danio rerio)
Actinopterygii slc38a9 36
  • 65.53 (n)
  • 65.4 (a)
slc38a9 37
  • 64 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F13H10.3 36
  • 51.13 (n)
  • 43.92 (a)
F13H10.3 37
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10819 37
  • 35 (a)
OneToOne
Species with no ortholog for SLC38A9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC38A9 Gene

ENSEMBL:
Gene Tree for SLC38A9 (if available)
TreeFam:
Gene Tree for SLC38A9 (if available)

Paralogs for SLC38A9 Gene

genes like me logo Genes that share paralogs with SLC38A9: view

No data available for Paralogs for SLC38A9 Gene

Variants for SLC38A9 Gene

Sequence variations from dbSNP and Humsavar for SLC38A9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs933672 -- 55,650,062(-) TTACC(C/T)TCTTA intron-variant
rs1133738 -- 55,697,631(+) CTCCC(A/C)CAACA intron-variant
rs1291291 -- 55,705,874(+) agcta(A/T)ttttt intron-variant
rs1314968 -- 55,696,582(-) AGGTG(A/G)GGGGG intron-variant
rs1314969 -- 55,696,575(-) GGGGT(C/T)AGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC38A9 Gene

Variant ID Type Subtype PubMed ID
dgv6070n71 CNV Loss 21882294
nsv830304 CNV Gain+Loss 17160897
nsv830305 CNV Loss 17160897
dgv6073n71 CNV Loss 21882294
dgv6074n71 CNV Loss 21882294
nsv881699 CNV Loss 21882294
nsv507253 CNV Insertion 20534489
nsv329478 CNV Loss 16902084
nsv830306 CNV Gain 17160897
dgv1799e1 CNV Complex 17122850
nsv507254 CNV Insertion 20534489

Relevant External Links for SLC38A9 Gene

HapMap Linkage Disequilibrium report
SLC38A9

Disorders for SLC38A9 Gene

Relevant External Links for SLC38A9

Genetic Association Database (GAD)
SLC38A9
genes like me logo Genes that share disorders with SLC38A9: view

No data available for UniProtKB/Swiss-Prot for SLC38A9 Gene

Publications for SLC38A9 Gene

  1. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. (PMID: 25561175) Rebsamen M. … Superti-Furga G. (Nature 2015) 2 3 4
  2. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. (PMID: 25567906) Wang S. … Sabatini D.M. (Science 2015) 2 3 4
  3. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 49
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3

Products for SLC38A9 Gene

Sources for SLC38A9 Gene

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