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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC38A8 Gene

protein-coding   GIFtS: 39
GCID: GC16M084043

Solute Carrier Family 38, Member 8

  Search for SLC38A8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 38, Member 81 2
Putative Sodium-Coupled Neutral Amino Acid Transporter 82
Solute Carrier Family 38 Member 82

External Ids:    HGNC: 324341   Entrez Gene: 1461672   Ensembl: ENSG000001665587   UniProtKB: A6NNN83   

Export aliases for SLC38A8 gene to outside databases

Previous GC identifers: GC16M082601 GC16M069797


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC38A8 Gene: 
SLC38A8 (solute carrier family 38, member 8) is a protein-coding gene. An important paralog of this gene is SLC38A7.

UniProtKB/Swiss-Prot: S38A8_HUMAN, A6NNN8
Function: Putative sodium-dependent amino acid/proton antiporter (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC38A8 gene promoter:
         AML1a   Pax-5   Olf-1   AP-4   GATA-1   E47   HNF-1A   HEN1   HNF-1   Hand1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SLC38A8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC38A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.3   Ensembl cytogenetic band:  16q23.3   HGNC cytogenetic band: 16q23.3

SLC38A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC38A8 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M084043:  view genomic region     (about GC identifiers)

Start:
84,043,272 bp from pter      End:
84,076,241 bp from pter
Size:
32,970 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S38A8_HUMAN, A6NNN8 (See protein sequence)
Recommended Name: Putative sodium-coupled neutral amino acid transporter 8  
Size: 435 amino acids; 46731 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for SLC38A8: NX_A6NNN8

Explore proteomics data for SLC38A8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NNN8

  • SLC38A8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC38A8 Protein Expression
    REFSEQ proteins: NP_001073911.1  
    ENSEMBL proteins: 
     ENSP00000299709   ENSP00000457737   ENSP00000455085  

    Human Recombinant Protein Products for SLC38A8: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    SLC38A8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SLC38A8 
    Orphan SLC38 transporters

    1 InterPro protein domain:
     IPR013057 AA_transpt_TM

    Graphical View of Domain Structure for InterPro Entry A6NNN8

    ProtoNet protein and cluster: A6NNN8

    UniProtKB/Swiss-Prot: S38A8_HUMAN, A6NNN8
    Similarity: Belongs to the amino acid/polyamine transporter 2 family


    SLC38A8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S38A8_HUMAN, A6NNN8
    Function: Putative sodium-dependent amino acid/proton antiporter (By similarity)

    Animal Models:

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC38A8

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003333amino acid transmembrane transport ----
    GO:0006814sodium ion transport IEA--
    GO:0006865amino acid transport IEA--

    SLC38A8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC38A8 (S38A8)

    1 HMDB Compound for SLC38A8    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    Search CenterWatch for drugs/clinical trials and news about SLC38A8 / S38A8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC38A8 gene: 
    NM_001080442.1  

    Unigene Cluster for SLC38A8:

    Solute carrier family 38, member 8
    Hs.461575  [show with all ESTs]
    Unigene Representative Sequence: NM_001080442
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000568003 ENST00000299709(uc002fhg.1) ENST00000568178 ENST00000569816

    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    1 DOTS entry:

    DT.91860771 

    1 AceView cDNA sequence:

    BF516149 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC38A8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGCTGTTTA
    SLC38A8 Expression
    About this image


    See SLC38A8 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.461575
        SABiosciences Custom PCR Arrays for SLC38A8
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC38A8 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc38a81 , 5 solute carrier family 38, member 81, 5 83.29(n)1
    82.6(a)1
      8 (67.80 cM)5
    2347881  NM_001009950.11  NP_001009950.11 
     1194796025 
    chicken
    (Gallus gallus)
    Aves LOC1008573091 putative sodium-coupled neutral amino acid transporter more 69.11(n)
    65.04(a)
      100857309  XM_003641908.1  XP_003641956.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC38A86
    Uncharacterized protein
    57(a)
    1 ↔ 1
    5(108324051-108333514)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.77472 Xenopus laevis transcribed sequence with weak similarity more 71.77(n)    48014685 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.182302 Transcribed sequence with weak similarity to protein more 76.56(n)    BQ132767.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AVT66
    AVT56
    (see all 3)
    Vacuolar aspartate and glutamate exporter; member ...
    Putative transporter, member of a family of seven ...
    (see all 3)
    17(a)
    17(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    V(399496-400842)
    II(49574-50953)


    ENSEMBL Gene Tree for SLC38A8 (if available)
    TreeFam Gene Tree for SLC38A8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC38A8 gene
    SLC38A72  
    1 SIMAP similar gene for SLC38A8 using alignment to 3 protein entries:     S38A8_HUMAN (see all proteins):
    SLC38A7

    SLC38A8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1820 SNPs in SLC38A8 are shown (see all 1820)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907349531,2
    --84042903(+) GAGCTC/TACTTA 1 -- ds50010--------
    rs1471106171,2
    --84042915(+) TGATGA/GGTATC 1 -- ds50010--------
    rs1385721421,2
    --84042928(+) TTTAAC/GAGAGA 1 -- ds50010--------
    rs1433903911,2
    --84042932(+) AGAGAC/GAGATT 1 -- ds50010--------
    rs1177784181,2
    C,F--84042946(+) ACACAG/CAGGAT 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs744958161,2
    C--84042949(+) CAGAGG/AATACA 1 -- ds50012Minor allele frequency- A:0.03CSA NA 122
    rs1149890621,2
    C,F--84042981(+) CAAGAG/ACAGAC 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs763576421,2
    C,F--84042988(+) AGACAC/GTGGAG 1 -- ds50011Minor allele frequency- G:0.04EA 120
    rs1482668941,2
    --84043051(+) GGAGG-/GAGCCTC 1 -- ds50010--------
    rs1457775771,2
    --84043076(+) AGAGGA/GAGCAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC38A8 (84043272 - 84076241 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for SLC38A8 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657139CNV Deletion23128226
    nsv1909CNV Loss18451855
    esv27048CNV Loss19812545
    nsv528396CNV Loss19592680
    dgv2928n71CNV Loss21882294
    dgv2931n71CNV Loss21882294
    nsv527489CNV Loss19592680
    nsv907040CNV Loss21882294
    dgv2929n71CNV Gain21882294
    nsv471106CNV Gain18288195

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC38A8 for disorders           About MalaCards

    SLC38A8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC38A8
    Human Genome Epidemiology (HuGE) Navigator: SLC38A8 (1 document)

    Export disorders for SLC38A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC38A8 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLC38A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease. (PubMed id 23213074)1 Adams L.A....Pennell C.E. (2013)
    3. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    4. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 146167 HGNC: 32434 AceView: LOC146167 Ensembl:ENSG00000166558 euGenes: HUgn146167
    ECgene: SLC38A8 H-InvDB: SLC38A8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC38A8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC38A8 gene:
    Search GeneIP for patents involving SLC38A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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