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Aliases for SLC38A7 Gene

Aliases for SLC38A7 Gene

  • Solute Carrier Family 38, Member 7 2 3
  • SNAT7 3 4 6
  • Solute Carrier Family 38 Member 7 3 4
  • Putative Sodium-Coupled Neutral Amino Acid Transporter 7 3
  • Amino Acid Transporter 3

External Ids for SLC38A7 Gene

Previous GeneCards Identifiers for SLC38A7 Gene

  • GC16M057258
  • GC16M044565

Summaries for SLC38A7 Gene

GeneCards Summary for SLC38A7 Gene

SLC38A7 (Solute Carrier Family 38, Member 7) is a Protein Coding gene. GO annotations related to this gene include L-glutamate transmembrane transporter activity and L-alanine transmembrane transporter activity. An important paralog of this gene is SLC38A8.

UniProtKB/Swiss-Prot for SLC38A7 Gene

  • Mediates sodium-dependent transport of amino acids, preferentially L-glutamine.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A7 Gene

Genomics for SLC38A7 Gene

Regulatory Elements for SLC38A7 Gene

Genomic Location for SLC38A7 Gene

Start:
58,665,109 bp from pter
End:
58,685,104 bp from pter
Size:
19,996 bases
Orientation:
Minus strand

Genomic View for SLC38A7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC38A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A7 Gene

Proteins for SLC38A7 Gene

  • Protein details for SLC38A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVC3-S38A7_HUMAN
    Recommended name:
    Putative sodium-coupled neutral amino acid transporter 7
    Protein Accession:
    Q9NVC3
    Secondary Accessions:
    • Q53GJ9
    • Q9H9I5

    Protein attributes for SLC38A7 Gene

    Size:
    462 amino acids
    Molecular mass:
    49966 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC38A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC38A7 Gene

Proteomics data for SLC38A7 Gene at MOPED

Post-translational modifications for SLC38A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC38A7 Gene

Domains for SLC38A7 Gene

Gene Families for SLC38A7 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC38A7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC38A7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVC3

UniProtKB/Swiss-Prot:

S38A7_HUMAN :
  • Q9NVC3
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A7: view

Function for SLC38A7 Gene

Molecular function for SLC38A7 Gene

UniProtKB/Swiss-Prot Function: Mediates sodium-dependent transport of amino acids, preferentially L-glutamine.

Gene Ontology (GO) - Molecular Function for SLC38A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005290 L-histidine transmembrane transporter activity IBA --
GO:0005313 L-glutamate transmembrane transporter activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0015179 L-amino acid transmembrane transporter activity ISS --
GO:0015180 L-alanine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC38A7: view

Phenotypes for SLC38A7 Gene

GenomeRNAi human phenotypes for SLC38A7:
genes like me logo Genes that share phenotypes with SLC38A7: view

miRNA for SLC38A7 Gene

miRTarBase miRNAs that target SLC38A7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC38A7 Gene

Localization for SLC38A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A7 Gene

Membrane; Multi-pass membrane protein. Note=In neurons, located in soma and axons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC38A7 Gene COMPARTMENTS Subcellular localization image for SLC38A7 gene
Compartment Confidence
plasma membrane 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC38A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030424 axon ISS --
GO:0043025 neuronal cell body ISS --
genes like me logo Genes that share ontologies with SLC38A7: view

Pathways for SLC38A7 Gene

SuperPathways for SLC38A7 Gene

No Data Available

Interacting Proteins for SLC38A7 Gene

Gene Ontology (GO) - Biological Process for SLC38A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006814 sodium ion transport ISS --
GO:0006867 asparagine transport IBA --
GO:0006868 glutamine transport IBA --
GO:0009847 spore germination --
genes like me logo Genes that share ontologies with SLC38A7: view

No data available for Pathways by source for SLC38A7 Gene

Compounds for SLC38A7 Gene

(1) HMDB Compounds for SLC38A7 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with SLC38A7: view

Transcripts for SLC38A7 Gene

Unigene Clusters for SLC38A7 Gene

Solute carrier family 38, member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A7 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - - -
SP12:
SP13: - -
SP14: - -

ExUns: 14 ^ 15 ^ 16a · 16b · 16c · 16d
SP1: -
SP2: - -
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SLC38A7 Gene

GeneLoc Exon Structure for
SLC38A7
ECgene alternative splicing isoforms for
SLC38A7

Expression for SLC38A7 Gene

mRNA expression in normal human tissues for SLC38A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC38A7 Gene

This gene is overexpressed in Testis (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC38A7 Gene

SOURCE GeneReport for Unigene cluster for SLC38A7 Gene Hs.10499

genes like me logo Genes that share expressions with SLC38A7: view

No data available for mRNA Expression by UniProt/SwissProt for SLC38A7 Gene

Orthologs for SLC38A7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC38A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC38A7 35
  • 99.71 (n)
  • 99.78 (a)
SLC38A7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC38A7 35
  • 90.91 (n)
  • 93.94 (a)
SLC38A7 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC38A7 35
  • 90.98 (n)
  • 94.16 (a)
SLC38A7 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc38a7 35
  • 89.25 (n)
  • 95.02 (a)
Slc38a7 16
Slc38a7 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC38A7 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC38A7 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc38a7 35
  • 88.74 (n)
  • 94.37 (a)
chicken
(Gallus gallus)
Aves SLC38A7 35
  • 79.52 (n)
  • 82.14 (a)
SLC38A7 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC38A7 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc38a7 35
  • 66.74 (n)
  • 69.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5352 35
zebrafish
(Danio rerio)
Actinopterygii slc38a7 35
  • 70.14 (n)
  • 72.51 (a)
slc38a7 36
  • 69 (a)
OneToOne
wufi23b07 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT5 36
  • 19 (a)
ManyToMany
AVT6 36
  • 20 (a)
ManyToMany
AVT6 38
AVT7 36
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
Species with no ortholog for SLC38A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC38A7 Gene

ENSEMBL:
Gene Tree for SLC38A7 (if available)
TreeFam:
Gene Tree for SLC38A7 (if available)

Paralogs for SLC38A7 Gene

Paralogs for SLC38A7 Gene

Selected SIMAP similar genes for SLC38A7 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SLC38A7: view

Variants for SLC38A7 Gene

Sequence variations from dbSNP and Humsavar for SLC38A7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs8074 -- 58,666,473(+) AAAAA(A/G)AAGGT utr-variant-3-prime
rs12696 -- 58,666,448(-) CTTCT(C/T)CCTGC utr-variant-3-prime
rs30822 -- 58,665,786(-) CCAGA(C/G)AGGGC utr-variant-3-prime
rs42943 -- 58,680,079(+) TCCGT(A/G)CTCAA reference, synonymous-codon, nc-transcript-variant
rs154468 -- 58,684,849(+) GCTCC(C/G)TGAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC38A7 Gene

Variant ID Type Subtype PubMed ID
dgv893e1 CNV Complex 17122850
nsv511049 CNV Complex 20534489
nsv509623 CNV Insertion 20534489
nsv510686 CNV Loss 20534489
nsv528513 CNV Loss 19592680

Relevant External Links for SLC38A7 Gene

HapMap Linkage Disequilibrium report
SLC38A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC38A7 Gene

Disorders for SLC38A7 Gene

Relevant External Links for SLC38A7

Genetic Association Database (GAD)
SLC38A7
genes like me logo Genes that share disorders with SLC38A7: view

No data available for UniProtKB/Swiss-Prot for SLC38A7 Gene

Publications for SLC38A7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C. … Stricker B.H. (Nat. Genet. 2009) 3 48
  3. Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. (PMID: 21511949) HAogglund M.G. … Fredriksson R. (J. Biol. Chem. 2011) 3
  4. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. (PMID: 23506890) SchiAPth H.B. … Fredriksson R. (Mol. Aspects Med. 2013) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SLC38A7 Gene

Sources for SLC38A7 Gene

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