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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC38A7 Gene

protein-coding GIFtS: 48
GCID: GC16M058699

solute carrier family 38, member 7

Explore 1 disease affiliated with
SLC38A7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 38, Member 7¹ ²
SNAT7² ³
FLJ10815¹
Amino Acid Transporter²
Putative Sodium-Coupled Neutral Amino Acid Transporter 7²

External Ids:	HGNC: 25582¹	Entrez Gene: 55238²	Ensembl: ENSG00000103042⁷	OMIM: 614236⁵	UniProtKB: Q9NVC3³

Export aliases for SLC38A7 gene to outside databases

Previous GC identifers: GC16M057258 GC16M044565

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: S38A7_HUMAN, Q9NVC3

Function: Mediates sodium-dependent transport of amino acids, preferentially L-glutamine (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC38A7 gene promoter:
SRF E2F-4 E2F-3a E2F-5 p53 SRF (504 AA) E2F-2 YY1 E2F E2F-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC38A7 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC38A7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC38A7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21 Ensembl cytogenetic band: 16q21 HGNC cytogenetic band: 16q21

SLC38A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC38A7 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M058699: view genomic region (about GC identifiers)

Start:	58,699,013 bp from pter	End:	58,719,008 bp from pter
Size:	19,996 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S38A7_HUMAN, Q9NVC3 (See protein sequence)

Recommended Name: Putative sodium-coupled neutral amino acid transporter 7

Size: 462 amino acids; 49966 Da

Subcellular location: Membrane; Multi-pass membrane protein (By similarity). Note=In neurons, located in soma and axons

(By similarity)

Secondary accessions: Q53GJ9 Q9H9I5

Alternative splicing: 2 isoforms: Q9NVC3-1 Q9NVC3-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC38A7: NX_Q9NVC3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NVC3

SLC38A7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060701.1

ENSEMBL proteins:

ENSP00000454646 ENSP00000219320 ENSP00000454325 ENSP00000455119 ENSP00000455362

ENSP00000457988 ENSP00000456464 ENSP00000455490 ENSP00000454734 ENSP00000457462

Human Recombinant Protein Products:

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	Uscn Proteins for SLC38A7

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--
GO:0030424	axon	ISS	--
GO:0043025	neuronal cell body	ISS	--

SLC38A7 for ontologies About GeneDecksing

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	Search for Antibodies for SLC38A7 at Abcam
	Uscn Antibodies for SLC38A7
	ThermoFisher Antibody for SLC38A7

Assay Products for SLC38A7:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for SLC38A7
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	Uscn ELISAs and CLIAs for SLC38A7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC38A7 for domains About GeneDecksing

1 InterPro domain/family:

IPR013057 AA_transpt_TM

Graphical View of Domain Structure for InterPro Entry Q9NVC3

ProtoNet protein and cluster: Q9NVC3

UniProtKB/Swiss-Prot: S38A7_HUMAN, Q9NVC3

Similarity: Belongs to the amino acid/polyamine transporter 2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: S38A7_HUMAN, Q9NVC3

Function: Mediates sodium-dependent transport of amino acids, preferentially L-glutamine (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: SLC38A7 Browse MicroRNA Expression Plasmids
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		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC38A7 (see all 15):
		hsa-miR-30c hsa-miR-132* hsa-miR-198 hsa-miR-3065-3p hsa-miR-30d hsa-miR-520a-5p hsa-miR-30a hsa-miR-525-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SLC38A7 3' UTR sequence

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Gene Editing
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		Search LifeMap BioReagents cell lines for SLC38A7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A7

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005290	L-histidine transmembrane transporter activity	IEA	--
GO:0005313	L-glutamate transmembrane transporter activity	IEA	--
GO:0015179	L-amino acid transmembrane transporter activity	ISS	--
GO:0015180	L-alanine transmembrane transporter activity	IEA	--
GO:0015182	L-asparagine transmembrane transporter activity	IEA	--

SLC38A7 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SLC38A7:

Increased S DNA content, incre

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC38A7

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006814	sodium ion transport	ISS	--
GO:0006867	asparagine transport	--	--
GO:0006868	glutamine transport	--	--
GO:0015807	L-amino acid transport	--	--
GO:0015808	L-alanine transport	--	--

SLC38A7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC38A7

1 HMDB Compound for SLC38A7 About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--

Search CenterWatch for drugs/clinical trials and news about SLC38A7 / S38A7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC38A7 gene:

NM_018231.1

Unigene Cluster for SLC38A7:

Solute carrier family 38, member 7

Hs.10499 [show with all ESTs]

Unigene Representative Sequence: BC063399

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000570101 ENST00000219320(uc002eod.1 uc010vil.1) ENST00000564100(uc002eoc.1)

ENST00000566598 ENST00000564010 ENST00000566953 ENST00000562149(uc002eoe.1)

ENST00000569209 ENST00000565785 ENST00000570214 ENST00000562397 ENST00000563196

ENST00000564391 ENST00000564720 ENST00000567930 ENST00000564964

miRNA Products:		OriGene 3'-UTR Clone: SLC38A7 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC38A7
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC38A7 (see all 15):
		hsa-miR-30c hsa-miR-132* hsa-miR-198 hsa-miR-3065-3p hsa-miR-30d hsa-miR-520a-5p hsa-miR-30a hsa-miR-525-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SLC38A7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC38A7 (see all 4) OriGene shRNA RFP: SLC38A7 OriGene siRNA: SLC38A7
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Additional cDNA sequence:

AK001677.1 AK022786.1 AK222932.1 AK299424.1 BC001961.1 BC063399.1 CR457236.1

12 DOTS entries:

DT.453772 DT.95246389 DT.120708929 DT.100780224 DT.100026216 DT.120708936 DT.120708939 DT.100780226

DT.100780227 DT.120708931 DT.120708938 DT.91836709

24/137 AceView cDNA sequences (see all 137):

BU845663 BU856351 CR457236 BU848841 BU552779 AL709157 AU132967 BP428676

BC063399 BM928738 BU183475 BF589781 BU543275 BU848717 BU849255 CA450436

AU141645 AA905628 BX441361 CR596148 AU133177 BU542349 AU143242 AL574447

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A7 (see all 14) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	·	12c	^	13	^
SP1:			-		-								-		-		-		-												-						-												-
SP2:													-		-		-		-												-						-								-		-		-		-
SP3:													-		-		-		-		-		-		-		-		-		-						-												-
SP4:													-		-		-		-												-						-
SP5:																															-						-		-										-

ExUns:	14	^	15	^	16a	·	16b	·	16c	·	16d
SP1:			-
SP2:	-		-
SP3:			-
SP4:
SP5:

ECgene alternative splicing isoforms for SLC38A7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC38A7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACCTGTCAG

About this image

SLC38A7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Head Mesenchyme

Limb

Autopod

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC38A7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC38A7

SOURCE GeneReport for Unigene cluster: Hs.10499

SABiosciences Custom PCR Arrays for SLC38A7

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLC38A7 gene from 4/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC38A7¹	solute carrier family 38, member 7	79.59(n) 82.14(a)		415677 XM_414044.3 XP_414044.2
lizard (Anolis carolinensis)	Reptilia	SLC38A7⁶	--	76(a)	1 ↔ 1	GL343773.1(37026-50434)
zebrafish (Danio rerio)	Actinopterygii	wufi23b07²	wufi23b07	76.31(n)		333955 CB361943.1
honey bee (Apis mellifera)	Insecta	--	--	30(a)	1 → many	GroupUn.138(17504-19414)

ENSEMBL Gene Tree for SLC38A7 (if available)
TreeFam Gene Tree for SLC38A7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC38A7 gene

SLC38A8²

1 SIMAP similar gene for SLC38A7 using alignment to 9 protein entries: S38A7_HUMAN (see all proteins):

SLC38A8

SLC38A7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190539603^1,2		--	58699798(+)	`CCCCAA/GTTATG`	1	--	ds500¹		0	--	--	--	--
rs154470^1,2	C,H,	--	58699834(-)	`TCTCAT/CTTCAC`	1	--	ds500¹		16		NS EA NA WA CSA	780
rs149110206^1,2		--	58699858(+)	`GGTAAC/TGGGGT`	1	--	ds500¹		0	--	--	--	--
rs143164384^1,2		--	58699928(+)	`GGCAGA/GCTCAA`	1	--	ds500¹		0	--	--	--	--
rs138834186^1,2		--	58700032(+)	`TGGCAC/TGATCT`	1	--	ds500¹		0	--	--	--	--
rs141305870^1,2		--	58700072(+)	`TTAAGC/TGGCTC`	1	--	ds500¹		0	--	--	--	--
rs146582259^1,2		--	58700171(+)	`TTGCCA/GTGTTG`	1	--	ds500¹		0	--	--	--	--
rs181628771^1,2		--	58700182(+)	`GCCAGG/TCTGGT`	1	--	ds500¹		0	--	--	--	--
rs184332916^1,2		--	58700190(+)	`GGTCTC/TGAACT`	1	--	ds500¹		0	--	--	--	--
rs139125379^1,2		--	58700217(+)	`CTGCCA/CGCCTT`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC38A7 (58699013 - 58719008 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC38A7
1 CNV: 4008

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC38A7

DNA2.0 Custom Variant and Variant Library Synthesis for SLC38A7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC38A7 for disorders           About GeneDecksing

OMIM gene information: 614236    OMIM disorders: --

1 disease for SLC38A7:    About MalaCards

neuronitis

Export disorders for SLC38A7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC38A7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC38A7)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification of SLC38A7 (SNAT7) protein as a glutam ine transporter expressed in neurons. (PubMed id 21511949)¹ HAogglund M.G....Fredriksson R. (2011)
Common variants at ten loci influence QT interval duration in the QTGEN Study. (PubMed id 19305408)¹ Newton-Cheh C....Stricker B.H. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55238	HGNC: 25582	AceView: FLJ10815	Ensembl:ENSG00000103042	euGenes: HUgn55238
ECgene: SLC38A7	H-InvDB: SLC38A7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC38A7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC38A7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SLC38A7 gene:
Search GeneIP for patents involving SLC38A7

GeneCards and IP:
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SLC38A7 Gene

solute carrier family 38, member 7

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SLC38A7 Gene

solute carrier family 38, member 7

Aliasesfor SLC38A7 gene

Summariesfor SLC38A7 gene

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External Searches for SLC38A7 gene

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