Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC38A6 Gene

Aliases for SLC38A6 Gene

  • Solute Carrier Family 38 Member 6 2 3 4 5
  • Na(+)-Coupled Neutral Amino Acid Transporter 6 3 4
  • N-System Amino Acid Transporter 1 3 4
  • NAT-1 3 4
  • SNAT6 3 4
  • Probable Sodium-Coupled Neutral Amino Acid Transporter 6 3
  • N System Amino Acid Transporter NAT-1 3
  • Solute Carrier Family 38, Member 6 2
  • NAT1 4

External Ids for SLC38A6 Gene

Previous GeneCards Identifiers for SLC38A6 Gene

  • GC14P055241
  • GC14P059437
  • GC14P060517
  • GC14P061447
  • GC14P041611

Summaries for SLC38A6 Gene

GeneCards Summary for SLC38A6 Gene

SLC38A6 (Solute Carrier Family 38 Member 6) is a Protein Coding gene. GO annotations related to this gene include amino acid transmembrane transporter activity. An important paralog of this gene is SLC38A3.

UniProtKB/Swiss-Prot for SLC38A6 Gene

  • Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A6 Gene

Genomics for SLC38A6 Gene

Regulatory Elements for SLC38A6 Gene

Enhancers for SLC38A6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F060756 0.8 Ensembl ENCODE 15 -223.2 -223194 3.6 JUN CEBPB EP300 ZBTB40 JUND STAT3 KDM1A PRDM10 SLC38A6 MNAT1 SIX4 TRMT5 MAD2L1P1
GH14F061100 1.4 FANTOM5 Ensembl ENCODE 12 +121.8 121789 4.6 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 FOS SP5 NFYC SLC38A6 TRMT5 C14orf39 SIX1 PPM1A LOC105378182 LOC101927756
GH14F060946 1 Ensembl 10.9 -34.9 -34914 0.4 SLC38A6 TRMT5 RNU6-398P SIX4 ENSG00000258656 SRMP2
GH14F061024 0.9 Ensembl ENCODE 10.7 +44.8 44818 2.1 SOX13 CTCF SAP130 JUN EBF1 RAD21 TEAD3 GATA3 ZNF143 SMC3 SIX1 SLC38A6 TRMT5 RNU6-398P PRKCH LOC101927756
GH14F060734 1.1 ENCODE 10.1 -245.4 -245407 3.1 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TRMT5 PCNX4 SCOCP1 SLC38A6 RBM8B RNU6-398P MNAT1 MAD2L1P1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC38A6 on UCSC Golden Path with GeneCards custom track

Promoters for SLC38A6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098069 486 3201 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS

Genomic Location for SLC38A6 Gene

Chromosome:
14
Start:
60,981,114 bp from pter
End:
61,083,733 bp from pter
Size:
102,620 bases
Orientation:
Plus strand

Genomic View for SLC38A6 Gene

Genes around SLC38A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC38A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC38A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A6 Gene

Proteins for SLC38A6 Gene

  • Protein details for SLC38A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZM9-S38A6_HUMAN
    Recommended name:
    Probable sodium-coupled neutral amino acid transporter 6
    Protein Accession:
    Q8IZM9
    Secondary Accessions:
    • C9JWA6
    • Q86SY5

    Protein attributes for SLC38A6 Gene

    Size:
    456 amino acids
    Molecular mass:
    50929 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC38A6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC38A6 Gene

Post-translational modifications for SLC38A6 Gene

  • Glycosylation at Asn 233 and Asn 283
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC38A6 Gene

Domains & Families for SLC38A6 Gene

Gene Families for SLC38A6 Gene

Protein Domains for SLC38A6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC38A6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZM9

UniProtKB/Swiss-Prot:

S38A6_HUMAN :
  • Belongs to the amino acid/polyamine transporter 2 family.
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A6: view

Function for SLC38A6 Gene

Molecular function for SLC38A6 Gene

UniProtKB/Swiss-Prot Function:
Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.

Gene Ontology (GO) - Molecular Function for SLC38A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC38A6: view
genes like me logo Genes that share phenotypes with SLC38A6: view

Animal Model Products

miRNA for SLC38A6 Gene

miRTarBase miRNAs that target SLC38A6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC38A6 Gene

Localization for SLC38A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A6 Gene

Cell membrane; Multi-pass membrane protein. Note=Colocalizes with synaptotagmins and SNAP25. {ECO:0000250 UniProtKB:G3UVW3}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC38A6 Gene COMPARTMENTS Subcellular localization image for SLC38A6 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC38A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC38A6: view

Pathways & Interactions for SLC38A6 Gene

SuperPathways for SLC38A6 Gene

No Data Available

Interacting Proteins for SLC38A6 Gene

Gene Ontology (GO) - Biological Process for SLC38A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006865 amino acid transport IEA --
genes like me logo Genes that share ontologies with SLC38A6: view

No data available for Pathways by source and SIGNOR curated interactions for SLC38A6 Gene

Drugs & Compounds for SLC38A6 Gene

(1) Additional Compounds for SLC38A6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC38A6: view

Transcripts for SLC38A6 Gene

Unigene Clusters for SLC38A6 Gene

Solute carrier family 38, member 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A6 Gene

No ASD Table

Relevant External Links for SLC38A6 Gene

GeneLoc Exon Structure for
SLC38A6
ECgene alternative splicing isoforms for
SLC38A6

Expression for SLC38A6 Gene

mRNA expression in normal human tissues for SLC38A6 Gene

Protein differential expression in normal tissues from HIPED for SLC38A6 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC38A6 Gene



Protein tissue co-expression partners for SLC38A6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC38A6 Gene:

SLC38A6

SOURCE GeneReport for Unigene cluster for SLC38A6 Gene:

Hs.200738
genes like me logo Genes that share expression patterns with SLC38A6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC38A6 Gene

Orthologs for SLC38A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC38A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC38A6 34 35
  • 98.61 (n)
dog
(Canis familiaris)
Mammalia SLC38A6 34 35
  • 91.74 (n)
cow
(Bos Taurus)
Mammalia SLC38A6 34 35
  • 91.01 (n)
rat
(Rattus norvegicus)
Mammalia Slc38a6 34
  • 85.53 (n)
mouse
(Mus musculus)
Mammalia Slc38a6 34 16 35
  • 83.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC38A6 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC38A6 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC38A6 34 35
  • 72.47 (n)
lizard
(Anolis carolinensis)
Reptilia SLC38A6 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc38a6 34
  • 70.94 (n)
Str.19095 34
zebrafish
(Danio rerio)
Actinopterygii slc38a6 34 35
  • 60.08 (n)
wufa94c12 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT2 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
CSA.4031 35
  • 40 (a)
OneToMany
Species where no ortholog for SLC38A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC38A6 Gene

ENSEMBL:
Gene Tree for SLC38A6 (if available)
TreeFam:
Gene Tree for SLC38A6 (if available)

Paralogs for SLC38A6 Gene

Variants for SLC38A6 Gene

Sequence variations from dbSNP and Humsavar for SLC38A6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10129272 -- 61,055,118(+) TTTTt(C/T)ttttt intron-variant
rs10129952 -- 60,992,126(+) CTTTA(C/T)TATCT intron-variant
rs10135773 -- 60,999,142(+) TTGTA(G/T)TTTTT intron-variant
rs10137033 -- 61,044,992(+) AAAGA(A/G)CATTT intron-variant
rs10139651 -- 61,052,586(+) AGTGT(A/G)GCAGT intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC38A6 Gene

Variant ID Type Subtype PubMed ID
dgv1281e59 CNV tandem duplication 20981092
esv2656644 CNV deletion 23128226
esv2748755 CNV deletion 23290073
esv3305148 CNV mobile element insertion 20981092
esv3379289 CNV duplication 20981092
esv3382258 CNV insertion 20981092
esv3634678 CNV loss 21293372
esv3634680 CNV gain 21293372
nsv1037387 CNV gain 25217958
nsv1049936 CNV loss 25217958
nsv1078207 CNV insertion 25765185
nsv1116744 CNV tandem duplication 24896259
nsv564881 CNV gain 21841781

Variation tolerance for SLC38A6 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC38A6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC38A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC38A6 Gene

Disorders for SLC38A6 Gene

Relevant External Links for SLC38A6

Genetic Association Database (GAD)
SLC38A6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC38A6

No disorders were found for SLC38A6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC38A6 Gene

Publications for SLC38A6 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  2. Histological analysis of SLC38A6 (SNAT6) expression in mouse brain shows selective expression in excitatory neurons with high expression in the synapses. (PMID: 24752331) Bagchi S. … Fredriksson R. (PLoS ONE 2014) 3 64
  3. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. (PMID: 23506890) SchiAPth H.B. … Fredriksson R. (Mol. Aspects Med. 2013) 3 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 4 64

Products for SLC38A6 Gene

Sources for SLC38A6 Gene

Content
Loading form....