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Aliases for SLC38A6 Gene

Aliases for SLC38A6 Gene

  • Solute Carrier Family 38 Member 6 2 3 4 5
  • Na(+)-Coupled Neutral Amino Acid Transporter 6 3 4
  • Solute Carrier Family 38, Member 6 2 3
  • N-System Amino Acid Transporter 1 3 4
  • NAT-1 3 4
  • SNAT6 3 4
  • N System Amino Acid Transporter NAT-1 3
  • NAT1 4

External Ids for SLC38A6 Gene

Previous GeneCards Identifiers for SLC38A6 Gene

  • GC14P055241
  • GC14P059437
  • GC14P060517
  • GC14P061447
  • GC14P041611

Summaries for SLC38A6 Gene

GeneCards Summary for SLC38A6 Gene

SLC38A6 (Solute Carrier Family 38 Member 6) is a Protein Coding gene. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include amino acid transmembrane transporter activity. An important paralog of this gene is SLC38A1.

UniProtKB/Swiss-Prot for SLC38A6 Gene

  • Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A6 Gene

Genomics for SLC38A6 Gene

Regulatory Elements for SLC38A6 Gene

Promoters for SLC38A6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC38A6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC38A6 Gene

60,981,114 bp from pter
61,083,733 bp from pter
102,620 bases
Plus strand

Genomic View for SLC38A6 Gene

Genes around SLC38A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC38A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC38A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A6 Gene

Proteins for SLC38A6 Gene

  • Protein details for SLC38A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable sodium-coupled neutral amino acid transporter 6
    Protein Accession:
    Secondary Accessions:
    • C9JWA6
    • Q86SY5

    Protein attributes for SLC38A6 Gene

    456 amino acids
    Molecular mass:
    50929 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC38A6 Gene


neXtProt entry for SLC38A6 Gene

Proteomics data for SLC38A6 Gene at MOPED

Post-translational modifications for SLC38A6 Gene

  • Glycosylation at Asn 233 and Asn 283
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC38A6 Gene

Domains & Families for SLC38A6 Gene

Gene Families for SLC38A6 Gene

Protein Domains for SLC38A6 Gene


Suggested Antigen Peptide Sequences for SLC38A6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the amino acid/polyamine transporter 2 family.
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A6: view

Function for SLC38A6 Gene

Molecular function for SLC38A6 Gene

UniProtKB/Swiss-Prot Function:
Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.
genes like me logo Genes that share phenotypes with SLC38A6: view

Animal Model Products

CRISPR Products

miRNA for SLC38A6 Gene

miRTarBase miRNAs that target SLC38A6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC38A6 Gene

Localization for SLC38A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A6 Gene

Cell membrane; Multi-pass membrane protein. Note=Colocalizes with synaptotagmins and SNAP25. {ECO:0000250 UniProtKB:G3UVW3}.

Subcellular locations from

Jensen Localization Image for SLC38A6 Gene COMPARTMENTS Subcellular localization image for SLC38A6 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC38A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC38A6: view

Pathways & Interactions for SLC38A6 Gene

genes like me logo Genes that share pathways with SLC38A6: view

Pathways by source for SLC38A6 Gene

Interacting Proteins for SLC38A6 Gene

Gene Ontology (GO) - Biological Process for SLC38A6 Gene


No data available for SIGNOR curated interactions for SLC38A6 Gene

Drugs & Compounds for SLC38A6 Gene

(1) Additional Compounds for SLC38A6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC38A6: view

Transcripts for SLC38A6 Gene

Unigene Clusters for SLC38A6 Gene

Solute carrier family 38, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A6 Gene

No ASD Table

Relevant External Links for SLC38A6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC38A6 Gene

mRNA expression in normal human tissues for SLC38A6 Gene

Protein differential expression in normal tissues from HIPED for SLC38A6 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC38A6 Gene

SOURCE GeneReport for Unigene cluster for SLC38A6 Gene Hs.200738

genes like me logo Genes that share expression patterns with SLC38A6: view

Protein tissue co-expression partners for SLC38A6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC38A6 Gene

Orthologs for SLC38A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC38A6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC38A6 35
  • 91.01 (n)
  • 88.82 (a)
SLC38A6 36
  • 85 (a)
(Canis familiaris)
Mammalia SLC38A6 35
  • 91.74 (n)
  • 87.5 (a)
SLC38A6 36
  • 84 (a)
(Mus musculus)
Mammalia Slc38a6 35
  • 83.99 (n)
  • 84.21 (a)
Slc38a6 16
Slc38a6 36
  • 82 (a)
(Pan troglodytes)
Mammalia SLC38A6 35
  • 98.61 (n)
  • 98.03 (a)
SLC38A6 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Slc38a6 35
  • 85.53 (n)
  • 84.65 (a)
(Monodelphis domestica)
Mammalia SLC38A6 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia SLC38A6 36
  • 68 (a)
(Gallus gallus)
Aves SLC38A6 35
  • 72.47 (n)
  • 73.66 (a)
SLC38A6 36
  • 70 (a)
(Anolis carolinensis)
Reptilia SLC38A6 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc38a6 35
  • 70.94 (n)
  • 71.01 (a)
Str.19095 35
(Danio rerio)
Actinopterygii slc38a6 35
  • 60.08 (n)
  • 59.76 (a)
wufa94c12 35
slc38a6 36
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT2 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
CSA.4031 36
  • 40 (a)
Species with no ortholog for SLC38A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC38A6 Gene

Gene Tree for SLC38A6 (if available)
Gene Tree for SLC38A6 (if available)

Paralogs for SLC38A6 Gene

Paralogs for SLC38A6 Gene

genes like me logo Genes that share paralogs with SLC38A6: view

Variants for SLC38A6 Gene

Sequence variations from dbSNP and Humsavar for SLC38A6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_037247 -
rs913484 -- 60,991,629(-) AAACG(C/T)CCAAG intron-variant
rs724141 -- 61,016,321(+) ATCGA(A/G)TTCAA intron-variant
rs958030 -- 61,075,430(-) CCCAC(A/G)GACTC intron-variant
rs2149300 -- 61,008,300(-) AAGAA(A/G)TCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC38A6 Gene

Variant ID Type Subtype PubMed ID
esv2748755 CNV Deletion 23290073
esv2656644 CNV Deletion 23128226
dgv1943n71 CNV Loss 21882294
nsv902004 CNV Loss 21882294
esv269426 CNV Insertion 20981092
esv259582 OTHER Complex 20981092
esv260030 OTHER Complex 20981092

Variation tolerance for SLC38A6 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC38A6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC38A6 Gene

Disorders for SLC38A6 Gene

Relevant External Links for SLC38A6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC38A6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC38A6 Gene

Publications for SLC38A6 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
  2. Histological analysis of SLC38A6 (SNAT6) expression in mouse brain shows selective expression in excitatory neurons with high expression in the synapses. (PMID: 24752331) Bagchi S. … Fredriksson R. (PLoS ONE 2014) 3
  3. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. (PMID: 23506890) SchiAPth H.B. … Fredriksson R. (Mol. Aspects Med. 2013) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for SLC38A6 Gene

Sources for SLC38A6 Gene

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