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Aliases for SLC38A6 Gene

Aliases for SLC38A6 Gene

  • Solute Carrier Family 38, Member 6 2 3
  • Na(+)-Coupled Neutral Amino Acid Transporter 6 3 4
  • N-System Amino Acid Transporter 1 3 4
  • NAT-1 3 4
  • SNAT6 3 4
  • Probable Sodium-Coupled Neutral Amino Acid Transporter 6 3
  • N System Amino Acid Transporter NAT-1 3
  • Solute Carrier Family 38 Member 6 4
  • NAT1 4

External Ids for SLC38A6 Gene

Summaries for SLC38A6 Gene

GeneCards Summary for SLC38A6 Gene

SLC38A6 (Solute Carrier Family 38, Member 6) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. An important paralog of this gene is SLC38A1.

UniProtKB/Swiss-Prot for SLC38A6 Gene

  • Probable sodium-dependent amino acid/proton antiporter

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A6 Gene

Genomics for SLC38A6 Gene

Genomic Location for SLC38A6 Gene

Start:
60,981,114 bp from pter
End:
61,083,733 bp from pter
Size:
102,620 bases
Orientation:
Plus strand

Genomic View for SLC38A6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC38A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A6 Gene

Regulatory Elements for SLC38A6 Gene

Proteins for SLC38A6 Gene

  • Protein details for SLC38A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZM9-S38A6_HUMAN
    Recommended name:
    Probable sodium-coupled neutral amino acid transporter 6
    Protein Accession:
    Q8IZM9
    Secondary Accessions:
    • C9JWA6
    • Q86SY5

    Protein attributes for SLC38A6 Gene

    Size:
    456 amino acids
    Molecular mass:
    50929 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC38A6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC38A6 Gene

Proteomics data for SLC38A6 Gene at MOPED

Post-translational modifications for SLC38A6 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn233 and Asn283

No data available for DME Specific Peptides for SLC38A6 Gene

Domains for SLC38A6 Gene

Gene Families for SLC38A6 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC38A6 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

S38A6_HUMAN
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.:
    • Q8IZM9
genes like me logo Genes that share domains with SLC38A6: view

Function for SLC38A6 Gene

Molecular function for SLC38A6 Gene

UniProtKB/Swiss-Prot Function: Probable sodium-dependent amino acid/proton antiporter

Gene Ontology (GO) - Molecular Function for SLC38A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC38A6: view

miRNA for SLC38A6 Gene

miRTarBase miRNAs that target SLC38A6

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC38A6 Gene

Localization for SLC38A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC38A6 Gene COMPARTMENTS Subcellular localization image for SLC38A6 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC38A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC38A6: view

Pathways for SLC38A6 Gene

genes like me logo Genes that share pathways with SLC38A6: view

Pathways by source for SLC38A6 Gene

Interacting Proteins for SLC38A6 Gene

Gene Ontology (GO) - Biological Process for SLC38A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006814 sodium ion transport IEA --
GO:0006865 amino acid transport --
genes like me logo Genes that share ontologies with SLC38A6: view

Compounds for SLC38A6 Gene

(1) HMDB Compounds for SLC38A6 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with SLC38A6: view

Transcripts for SLC38A6 Gene

Unigene Clusters for SLC38A6 Gene

Solute carrier family 38, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A6 Gene

No ASD Table

Relevant External Links for SLC38A6 Gene

GeneLoc Exon Structure for
SLC38A6
ECgene alternative splicing isoforms for
SLC38A6

Expression for SLC38A6 Gene

mRNA expression in normal human tissues for SLC38A6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC38A6 Gene

SOURCE GeneReport for Unigene cluster for SLC38A6 Gene Hs.200738

genes like me logo Genes that share expressions with SLC38A6: view

Orthologs for SLC38A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC38A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC38A6 36
  • 98.61 (n)
  • 98.03 (a)
SLC38A6 37
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC38A6 36
  • 91.01 (n)
  • 88.82 (a)
SLC38A6 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC38A6 36
  • 91.74 (n)
  • 87.5 (a)
SLC38A6 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc38a6 36
  • 83.99 (n)
  • 84.21 (a)
Slc38a6 16
Slc38a6 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC38A6 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC38A6 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc38a6 36
  • 85.53 (n)
  • 84.65 (a)
chicken
(Gallus gallus)
Aves SLC38A6 36
  • 72.47 (n)
  • 73.66 (a)
SLC38A6 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC38A6 37
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc38a6 36
  • 70.94 (n)
  • 71.01 (a)
Str.19095 36
zebrafish
(Danio rerio)
Actinopterygii slc38a6 36
  • 60.08 (n)
  • 59.76 (a)
slc38a6 37
  • 57 (a)
OneToOne
wufa94c12 36
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT2 37
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToMany
CSA.4031 37
  • 40 (a)
OneToMany
Species with no ortholog for SLC38A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC38A6 Gene

ENSEMBL:
Gene Tree for SLC38A6 (if available)
TreeFam:
Gene Tree for SLC38A6 (if available)

Paralogs for SLC38A6 Gene

Paralogs for SLC38A6 Gene

genes like me logo Genes that share paralogs with SLC38A6: view

Variants for SLC38A6 Gene

Sequence variations from dbSNP and Humsavar for SLC38A6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs724141 -- 61,016,321(+) ATCGA(A/G)TTCAA intron-variant
rs913484 -- 60,991,629(-) AAACG(C/T)CCAAG intron-variant
rs958030 -- 61,075,430(-) CCCAC(A/G)GACTC intron-variant
rs1465143 -- 61,069,104(-) TTTAA(C/T)TGGTT intron-variant
rs1465144 -- 61,069,100(-) ACTGG(C/T)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC38A6 Gene

Variant ID Type Subtype PubMed ID
esv2748755 CNV Deletion 23290073
esv2656644 CNV Deletion 23128226
dgv1943n71 CNV Loss 21882294
nsv902004 CNV Loss 21882294
esv269426 CNV Insertion 20981092
esv259582 OTHER Complex 20981092
esv260030 OTHER Complex 20981092

Relevant External Links for SLC38A6 Gene

HapMap Linkage Disequilibrium report
SLC38A6

Disorders for SLC38A6 Gene

Relevant External Links for SLC38A6

Genetic Association Database (GAD)
SLC38A6
genes like me logo Genes that share disorders with SLC38A6: view

No data available for UniProtKB/Swiss-Prot for SLC38A6 Gene

Publications for SLC38A6 Gene

  1. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 3
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for SLC38A6 Gene

Sources for SLC38A6 Gene

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