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SLC38A5 Gene

protein-coding   GIFtS: 55
GCID: GC0XM048317

Solute Carrier Family 38, Member 5

  Search for SLC38A5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 38, Member 51 2     pp71942
SN22 3 5     Sodium-Coupled Neutral Amino Acid Transporter 52
System N Transporter 22 3     Solute Carrier Family 38 (Amino Acid Transporter), Member 52
JM242 3     Transport System N, Protein 22
SNAT52 3     Solute Carrier Family 38 Member 53

External Ids:    HGNC: 180701   Entrez Gene: 927452   Ensembl: ENSG000000174837   OMIM: 3006495   UniProtKB: Q8WUX13   

Export aliases for SLC38A5 gene to outside databases

Previous GC identifers: GC0XM047119 GC0XM046577 GC0XM047143 GC0XM047362 GC0XM048073 GC0XM048201 GC0XM045981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC38A5 Gene:
The protein encoded by this gene is a system N sodium-coupled amino acid transporter. The encoded protein
transports glutamine, asparagine, histidine, serine, alanine, and glycine across the cell membrane, but does not
transport charged amino acids, imino acids, or N-alkylated amino acids. Alternative splicing results in multiple
transcript variants, but the full-length nature of some of these variants has not been determined. (provided by
RefSeq, Aug 2013)

GeneCards Summary for SLC38A5 Gene:
SLC38A5 (solute carrier family 38, member 5) is a protein-coding gene. GO annotations related to this gene include glycine transmembrane transporter activity. An important paralog of this gene is SLC38A4.

UniProtKB/Swiss-Prot: S38A5_HUMAN, Q8WUX1
Function: Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the
saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine,
asparagine, alanine, serine, glutamine and histidine with sodium




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_079573.5  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC38A5 gene promoter:
         E2F-3a   E2F-4   CREB   p53   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC38A5 promoter sequence
   Search Chromatin IP Primers for SLC38A5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC38A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

SLC38A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC38A5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM048317:  view genomic region     (about GC identifiers)

Start:
48,316,920 bp from pter      End:
48,328,644 bp from pter
Size:
11,725 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S38A5_HUMAN, Q8WUX1 (See protein sequence)
Recommended Name: Sodium-coupled neutral amino acid transporter 5  
Size: 472 amino acids; 51457 Da
Sequence caution: Sequence=AAL55865.1; Type=Frameshift; Positions=161, 466;
Secondary accessions: B3KT20 B5MDE6 B7WPJ9 Q6PIW9 Q8WYU2 Q96PQ4
Alternative splicing: 2 isoforms:  Q8WUX1-1   Q8WUX1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC38A5: NX_Q8WUX1

Explore proteomics data for SLC38A5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys37, Lys369
  • Glycosylation2 at Asn226
  • Modification sites at PhosphoSitePlus

  • See SLC38A5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_277053.2  
    ENSEMBL proteins: 
     ENSP00000366073   ENSP00000366071   ENSP00000402988   ENSP00000407258   ENSP00000403976  
     ENSP00000389644   ENSP00000416948   ENSP00000313740  
    Reactome Protein details: Q8WUX1

    SLC38A5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SNAT5
    System N-like transporters

    1 InterPro protein domain:
     IPR013057 AA_transpt_TM

    Graphical View of Domain Structure for InterPro Entry Q8WUX1

    ProtoNet protein and cluster: Q8WUX1

    UniProtKB/Swiss-Prot: S38A5_HUMAN, Q8WUX1
    Similarity: Belongs to the amino acid/polyamine transporter 2 family


    Find genes that share domains with SLC38A5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S38A5_HUMAN, Q8WUX1
    Function: Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the
    saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine,
    asparagine, alanine, serine, glutamine and histidine with sodium
    Enzyme regulation: Not inhibited by lithium
    Biophysicochemical properties: Kinetic parameters: KM=0.6 mM for histidine (at pH 8.0);

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015171amino acid transmembrane transporter activity ----
    GO:0015175neutral amino acid transmembrane transporter activity ----
    GO:0015187glycine transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC38A5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC38A5:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC38A5
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    miRNA
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    miRTarBase miRNAs that target SLC38A5:
    hsa-let-7b-5p (MIRT032417), hsa-mir-124-3p (MIRT022809), hsa-mir-155-5p (MIRT020892), hsa-mir-30a-5p (MIRT028564), hsa-mir-16-5p (MIRT001413)

    Block miRNA regulation of human, mouse, rat SLC38A5 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SLC38A5:
    hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmidSLC38A5 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SLC38A5 (NM_033518)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S38A5_HUMAN, Q8WUX1: Cell membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC38A5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC38A5 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Amino acid transport across the plasma membrane0.32
    2Circadian entrainment
    GABAergic synapse0.53


    Find genes that share SuperPaths with SLC38A5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC38A5
        Amino acid transport across the plasma membrane


    1 Kegg Pathway  (Kegg details for SLC38A5):
        GABAergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC38A5: 
              Oxidative Stress in human mouse rat
              Drug Transporters in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC38A5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC38A5 (ENSP000003137404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003333amino acid transmembrane transport ----
    GO:0006811ion transport TAS--
    GO:0006865amino acid transport TAS--
    GO:0015804neutral amino acid transport ----
    GO:0015816glycine transport ----

    Find genes that share ontologies with SLC38A5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC38A5 (S38A5)

    1 HMDB Compound for SLC38A5    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    2 IUPHAR Ligands for SLC38A5 (SNAT5)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]histidine
    NoneNone--
    [14C]histidine
    NoneNone--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC38A5 gene: 
    NM_033518.3  

    Unigene Cluster for SLC38A5:

    Solute carrier family 38, member 5
    Hs.195155  [show with all ESTs]
    Unigene Representative Sequence: AF276889
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376876 ENST00000376875(uc004djk.4) ENST00000497336 ENST00000462359
    ENST00000480105 ENST00000494034 ENST00000440085 ENST00000441948 ENST00000413668
    ENST00000416711 ENST00000488083 ENST00000429543 ENST00000317669(uc010nid.3)

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate SLC38A5:
    hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmidSLC38A5 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SLC38A5 (NM_033518)
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC38A5
      QuantiFast Probe-based Assays in human, mouse, rat SLC38A5

    Additional mRNA sequence: 

    AF276889.1 AK094788.1 BC019246.2 BC027721.2 

    12 DOTS entries:

    DT.425866  DT.91761993  DT.91761987  DT.95167171  DT.95167165  DT.95167169  DT.121278348  DT.95167164 
    DT.121278336  DT.95167170  DT.95368883  DT.95167163 

    Selected AceView cDNA sequences (see all 146):

    BC019246 BU154264 BX443861 AA149754 BU187175 AA612723 BM141814 BQ053504 
    BE151973 AA714176 BC027721 R16124 BE272907 BX098636 BF734846 BM926518 
    BU677924 AK094788 BM728577 BU627635 AA149673 CF540964 BI769547 BE151978 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC38A5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGAGGAG
    SLC38A5 Expression
    About this image


    SLC38A5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Endothelium (Cardiovascular System)
             Mature brain microvascular endothelial cells
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
    SLC38A5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC38A5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.195155

    UniProtKB/Swiss-Prot: S38A5_HUMAN, Q8WUX1
    Tissue specificity: Predominantly expressed in stomach, brain, liver, lung and intestinal tract

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC38A5: 
              Oxidative Stress in human mouse rat
              Drug Transporters in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC38A5 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc38a51 , 5 solute carrier family 38, member 51, 5 86.78(n)1
    88.06(a)1
      X (3.74 cM)5
    2098371  NM_172479.21  NP_766067.21 
     82711335 
    chicken
    (Gallus gallus)
    Aves SLC38A56
    solute carrier family 38, member 5
    62(a)
    1 ↔ 1
    12(3204934-3208668)
    lizard
    (Anolis carolinensis)
    Reptilia SLC38A56
    solute carrier family 38, member 5
    66(a)
    1 ↔ 1
    2(69433493-69461873)
    zebrafish
    (Danio rerio)
    Actinopterygii slc38a5b6
    slc38a5a6
    solute carrier family 38, member 5a
    64(a)
    59(a)
    1 ↔ many
    1 ↔ many
    8(24432917-24465405) ENSDARG00000014587
    8(26468724-26478746) ENSDARG00000009901


    ENSEMBL Gene Tree for SLC38A5 (if available)
    TreeFam Gene Tree for SLC38A5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC38A5 gene
    SLC38A42  SLC38A62  SLC38A12  SLC38A22  SLC38A112  SLC38A102  
    5 SIMAP similar genes for SLC38A5 using alignment to 6 protein entries:     S38A5_HUMAN (see all proteins):
    SLC38A3    SLC38A6    SLC38A1    SLC38A2    SLC38A4

    Find genes that share paralogs with SLC38A5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC38A5 (see all 247)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1927534831,2
    --48236483(+) CCGAGA/TGAATG 1 -- int10--------
    rs1851338991,2
    --48236530(+) CTCTGC/TCGCCC 1 -- int10--------
    rs44802431,2
    C--48236590(+) TGGGTC/TCAAGC 1 -- int13Minor allele frequency- T:0.00NA 5
    rs1429490461,2
    --48236604(+) TCTCCC/TGCCTT 1 -- int10--------
    rs1900133011,2
    --48236628(+) GCTGGA/GACTAT 1 -- int10--------
    rs1474597101,2
    --48236654(+) ACCCAA/GTTAAT 1 -- int10--------
    rs59066701,2
    C,F,H--48236874(+) CACTCA/GCAGGG 1 -- int116Minor allele frequency- G:0.92NS EA NA 2120
    rs1428825221,2
    C--48237242(+) AACCAC/TGTTCA 1 -- ut310--------
    rs1506488361,2
    C--48237316(+) ATGTGC/TATGCG 1 -- ut310--------
    rs172811881,2,,4
    C,F,H--48237417(+) CGGCCA/GTGAAG 2 T M mis128Minor allele frequency- G:0.06NA NS EA 7132

    HapMap Linkage Disequilibrium report for SLC38A5 (48316920 - 48328644 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC38A5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv267622CNV Insertion20981092
    nsv528292CNV Gain19592680
    esv32909CNV Gain+Loss17666407

    Locus Specific Mutation Databases (LSDB): SLC38A5

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300649    OMIM disorders: --


    Find genes that share disorders with SLC38A5           About GenesLikeMe


    Export disorders for SLC38A5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC38A5 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with SLC38A5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N. (PubMed id 11243884)1, 2, 3 Nakanishi T.... Ganapathy V. (Biochem. Biophys. Res. Commun. 2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    4. Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined. (PubMed id 22382077)1 Desjardins P....Butterworth R.F. (Neurochem. Int. 2012)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (amp 2011)
    9. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    10. The evolutionary history and tissue mapping of amino acid transporters belonging to solute carrier families SLC32, SLC36, and SLC38. (PubMed id 18418736)1 Sundberg B.E....Fredriksson R. (J. Mol. Neurosci. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92745 HGNC: 18070 AceView: SLC38A5 Ensembl:ENSG00000017483 euGenes: HUgn92745
    ECgene: SLC38A5 Kegg: 92745 H-InvDB: SLC38A5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC38A5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC38A5 gene:
    Search GeneIP for patents involving SLC38A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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