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Aliases for SLC38A5 Gene

Aliases for SLC38A5 Gene

  • Solute Carrier Family 38 Member 5 2 3 4 5
  • System N Transporter 2 3 4
  • SNAT5 3 4
  • JM24 3 4
  • SN2 3 4
  • Solute Carrier Family 38 (Amino Acid Transporter), Member 5 3
  • Sodium-Coupled Neutral Amino Acid Transporter 5 3
  • Solute Carrier Family 38, Member 5 2
  • Transport System N, Protein 2 3
  • Pp7194 3

External Ids for SLC38A5 Gene

Previous GeneCards Identifiers for SLC38A5 Gene

  • GC0XM047119
  • GC0XM046577
  • GC0XM047143
  • GC0XM047362
  • GC0XM048073
  • GC0XM048201
  • GC0XM048317
  • GC0XM045981

Summaries for SLC38A5 Gene

Entrez Gene Summary for SLC38A5 Gene

  • The protein encoded by this gene is a system N sodium-coupled amino acid transporter. The encoded protein transports glutamine, asparagine, histidine, serine, alanine, and glycine across the cell membrane, but does not transport charged amino acids, imino acids, or N-alkylated amino acids. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Aug 2013]

GeneCards Summary for SLC38A5 Gene

SLC38A5 (Solute Carrier Family 38 Member 5) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Circadian entrainment. GO annotations related to this gene include amino acid transmembrane transporter activity and glycine transmembrane transporter activity. An important paralog of this gene is SLC38A3.

UniProtKB/Swiss-Prot for SLC38A5 Gene

  • Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A5 Gene

Genomics for SLC38A5 Gene

Regulatory Elements for SLC38A5 Gene

Enhancers for SLC38A5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF048427 0.2 Ensembl 14.1 +42.8 42756 0.6 SLC38A5 ENSG00000231489 ENSG00000235350 SSXP6
GH0XF048491 1.1 FANTOM5 Ensembl ENCODE 13.5 -22.4 -22419 1.7 SMARCE1 RNF2 NR2F1 JUN JUNB DPF2 ZBTB7A NR2F2 ARID1B JUND SLC38A5 EBP RBM3 WAS PORCN OTUD5 GC0XP048480 LOC101927635
GH0XF048494 0.7 Ensembl 12.7 -23.9 -23945 0.4 CTCF ZNF654 NFIA NRF1 SMC3 REST RAD21 EBP SLC38A5 GC0XP048480 LOC101927635
GH0XF049037 1.1 ENCODE 6.4 -570.9 -570876 7.0 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 GAGE12J GAGE12C GAGE12G GAGE12H GAGE2A SSXP9 PAGE1 ENSG00000270747 SSX9 PRAF2
GH0XF048485 1.4 FANTOM5 Ensembl ENCODE 5.7 -18.1 -18137 6.0 HDAC1 KLF1 ESRRA TAF1 ETV1 ZNF121 POLR2A RCOR1 ZNF548 ZSCAN29 FTSJ1 ENSG00000204620 PORCN ZNF81 EBP ENSG00000270012 ENSG00000228343 SLC38A5 ZNF630 RBM3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC38A5 on UCSC Golden Path with GeneCards custom track

Promoters for SLC38A5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001917139 1856 2401 HDGF HDAC1 PKNOX1 SIN3A NFXL1 DMAP1 RAD21 GATA2 SMARCA5 ZNF263

Genomic Location for SLC38A5 Gene

Chromosome:
X
Start:
48,458,537 bp from pter
End:
48,470,256 bp from pter
Size:
11,720 bases
Orientation:
Minus strand

Genomic View for SLC38A5 Gene

Genes around SLC38A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC38A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC38A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A5 Gene

Proteins for SLC38A5 Gene

  • Protein details for SLC38A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUX1-S38A5_HUMAN
    Recommended name:
    Sodium-coupled neutral amino acid transporter 5
    Protein Accession:
    Q8WUX1
    Secondary Accessions:
    • B3KT20
    • B5MDE6
    • B7WPJ9
    • Q6PIW9
    • Q8WYU2
    • Q96PQ4

    Protein attributes for SLC38A5 Gene

    Size:
    472 amino acids
    Molecular mass:
    51457 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL55865.1; Type=Frameshift; Positions=161, 466; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC38A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC38A5 Gene

Post-translational modifications for SLC38A5 Gene

  • Ubiquitination at Lys 37 and Lys 369
  • Glycosylation at Asn 226
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC38A5 Gene

Domains & Families for SLC38A5 Gene

Gene Families for SLC38A5 Gene

Protein Domains for SLC38A5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC38A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUX1

UniProtKB/Swiss-Prot:

S38A5_HUMAN :
  • Belongs to the amino acid/polyamine transporter 2 family.
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A5: view

Function for SLC38A5 Gene

Molecular function for SLC38A5 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.6 mM for histidine (at pH 8.0) {ECO:0000269 PubMed:11243884};
UniProtKB/Swiss-Prot EnzymeRegulation:
Not inhibited by lithium.
UniProtKB/Swiss-Prot Function:
Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium.

Gene Ontology (GO) - Molecular Function for SLC38A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity TAS --
GO:0015187 glycine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC38A5: view
genes like me logo Genes that share phenotypes with SLC38A5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC38A5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC38A5 Gene

Localization for SLC38A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC38A5 Gene COMPARTMENTS Subcellular localization image for SLC38A5 gene
Compartment Confidence
plasma membrane 5
cytosol 3
chloroplast 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC38A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC38A5: view

Pathways & Interactions for SLC38A5 Gene

genes like me logo Genes that share pathways with SLC38A5: view

Interacting Proteins for SLC38A5 Gene

Gene Ontology (GO) - Biological Process for SLC38A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IEA --
GO:0006865 amino acid transport TAS --
GO:0015816 glycine transport IEA --
genes like me logo Genes that share ontologies with SLC38A5: view

No data available for SIGNOR curated interactions for SLC38A5 Gene

Drugs & Compounds for SLC38A5 Gene

(2) Drugs for SLC38A5 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>14</sup>C]histidine Pharma 0
[<sup>3</sup>H]histidine Pharma 0

(1) Additional Compounds for SLC38A5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC38A5: view

Transcripts for SLC38A5 Gene

Unigene Clusters for SLC38A5 Gene

Solute carrier family 38, member 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A5 Gene

No ASD Table

Relevant External Links for SLC38A5 Gene

GeneLoc Exon Structure for
SLC38A5
ECgene alternative splicing isoforms for
SLC38A5

Expression for SLC38A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC38A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC38A5 Gene

This gene is overexpressed in Pancreas (x12.3) and Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for SLC38A5 Gene

This gene is overexpressed in Pancreas (48.5) and Fetal Liver (20.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC38A5 Gene



Protein tissue co-expression partners for SLC38A5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC38A5 Gene:

SLC38A5

SOURCE GeneReport for Unigene cluster for SLC38A5 Gene:

Hs.195155

mRNA Expression by UniProt/SwissProt for SLC38A5 Gene:

Q8WUX1-S38A5_HUMAN
Tissue specificity: Predominantly expressed in stomach, brain, liver, lung and intestinal tract.
genes like me logo Genes that share expression patterns with SLC38A5: view

Primer Products

Orthologs for SLC38A5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC38A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC38A5 34 35
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia SLC38A5 34 35
  • 90.43 (n)
dog
(Canis familiaris)
Mammalia SLC38A5 34 35
  • 87.27 (n)
mouse
(Mus musculus)
Mammalia Slc38a5 34 16 35
  • 86.78 (n)
rat
(Rattus norvegicus)
Mammalia Slc38a5 34
  • 86.57 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC38A5 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC38A5 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC38A5 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC38A5 35
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc38a5b 35
  • 64 (a)
OneToMany
slc38a5a 35
  • 59 (a)
OneToMany
Species where no ortholog for SLC38A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC38A5 Gene

ENSEMBL:
Gene Tree for SLC38A5 (if available)
TreeFam:
Gene Tree for SLC38A5 (if available)

Paralogs for SLC38A5 Gene

Paralogs for SLC38A5 Gene

(5) SIMAP similar genes for SLC38A5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC38A5: view

Variants for SLC38A5 Gene

Sequence variations from dbSNP and Humsavar for SLC38A5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs863223370 Uncertain significance 48,461,763(-) TGCTT(C/T)TGTCT reference, missense
rs111500734 -- 48,467,023(+) GCCCA(C/T)GATGG reference, missense
rs111920516 -- 48,471,440(+) CTCTC(A/T)CACAC upstream-variant-2KB
rs112151553 -- 48,466,743(+) CTCCA(C/G)AGTCT intron-variant
rs112266883 -- 48,462,628(+) AAAAC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC38A5 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV gain+loss 17666407
esv3340506 CNV insertion 20981092
nsv528292 CNV gain 19592680

Variation tolerance for SLC38A5 Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC38A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC38A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC38A5 Gene

Disorders for SLC38A5 Gene

Relevant External Links for SLC38A5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC38A5

No disorders were found for SLC38A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC38A5 Gene

Publications for SLC38A5 Gene

  1. Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N. (PMID: 11243884) Nakanishi T. … Ganapathy V. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. (PMID: 23506890) SchiAPth H.B. … Fredriksson R. (Mol. Aspects Med. 2013) 3 64
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64

Products for SLC38A5 Gene

Sources for SLC38A5 Gene

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