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Aliases for SLC38A5 Gene

Aliases for SLC38A5 Gene

  • Solute Carrier Family 38, Member 5 2 3
  • SN2 3 4 6
  • System N Transporter 2 3 4
  • SNAT5 3 4
  • JM24 3 4
  • Solute Carrier Family 38 (Amino Acid Transporter), Member 5 3
  • Sodium-Coupled Neutral Amino Acid Transporter 5 3
  • Solute Carrier Family 38 Member 5 4
  • Transport System N, Protein 2 3
  • Pp7194 3

External Ids for SLC38A5 Gene

Previous GeneCards Identifiers for SLC38A5 Gene

  • GC0XM047119
  • GC0XM046577
  • GC0XM047143
  • GC0XM047362
  • GC0XM048073
  • GC0XM048201
  • GC0XM048317
  • GC0XM045981

Summaries for SLC38A5 Gene

Entrez Gene Summary for SLC38A5 Gene

  • The protein encoded by this gene is a system N sodium-coupled amino acid transporter. The encoded protein transports glutamine, asparagine, histidine, serine, alanine, and glycine across the cell membrane, but does not transport charged amino acids, imino acids, or N-alkylated amino acids. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Aug 2013]

GeneCards Summary for SLC38A5 Gene

SLC38A5 (Solute Carrier Family 38, Member 5) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Circadian entrainment. GO annotations related to this gene include glycine transmembrane transporter activity. An important paralog of this gene is SLC38A1.

UniProtKB/Swiss-Prot for SLC38A5 Gene

  • Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A5 Gene

Genomics for SLC38A5 Gene

Regulatory Elements for SLC38A5 Gene

Genomic Location for SLC38A5 Gene

Start:
48,458,537 bp from pter
End:
48,470,256 bp from pter
Size:
11,720 bases
Orientation:
Minus strand

Genomic View for SLC38A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC38A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A5 Gene

Proteins for SLC38A5 Gene

  • Protein details for SLC38A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUX1-S38A5_HUMAN
    Recommended name:
    Sodium-coupled neutral amino acid transporter 5
    Protein Accession:
    Q8WUX1
    Secondary Accessions:
    • B3KT20
    • B5MDE6
    • B7WPJ9
    • Q6PIW9
    • Q8WYU2
    • Q96PQ4

    Protein attributes for SLC38A5 Gene

    Size:
    472 amino acids
    Molecular mass:
    51457 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL55865.1; Type=Frameshift; Positions=161, 466; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC38A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC38A5 Gene

Proteomics data for SLC38A5 Gene at MOPED

Post-translational modifications for SLC38A5 Gene

  • Ubiquitination at Lys37 and Lys369
  • Glycosylation at Asn226
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC38A5 Gene

Domains for SLC38A5 Gene

Gene Families for SLC38A5 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC38A5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC38A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUX1

UniProtKB/Swiss-Prot:

S38A5_HUMAN :
  • Q8WUX1
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A5: view

Function for SLC38A5 Gene

Molecular function for SLC38A5 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.6 mM for histidine (at pH 8.0) {ECO:0000269 PubMed:11243884};
UniProtKB/Swiss-Prot EnzymeRegulation: Not inhibited by lithium.
UniProtKB/Swiss-Prot Function: Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium.

Gene Ontology (GO) - Molecular Function for SLC38A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity --
GO:0015175 neutral amino acid transmembrane transporter activity --
GO:0015187 glycine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC38A5: view

Phenotypes for SLC38A5 Gene

GenomeRNAi human phenotypes for SLC38A5:
genes like me logo Genes that share phenotypes with SLC38A5: view

Animal Model Products

CRISPR Products

miRNA for SLC38A5 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC38A5 Gene

Localization for SLC38A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC38A5 Gene COMPARTMENTS Subcellular localization image for SLC38A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC38A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC38A5: view

Pathways for SLC38A5 Gene

genes like me logo Genes that share pathways with SLC38A5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC38A5 Gene

Gene Ontology (GO) - Biological Process for SLC38A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006811 ion transport TAS --
GO:0006865 amino acid transport TAS --
GO:0015804 neutral amino acid transport --
GO:0015816 glycine transport IBA --
genes like me logo Genes that share ontologies with SLC38A5: view

Compounds for SLC38A5 Gene

(1) HMDB Compounds for SLC38A5 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(2) IUPHAR Ligand for SLC38A5 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]histidine None None
[14C]histidine None None
genes like me logo Genes that share compounds with SLC38A5: view

Transcripts for SLC38A5 Gene

Unigene Clusters for SLC38A5 Gene

Solute carrier family 38, member 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC38A5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A5 Gene

No ASD Table

Relevant External Links for SLC38A5 Gene

GeneLoc Exon Structure for
SLC38A5
ECgene alternative splicing isoforms for
SLC38A5

Expression for SLC38A5 Gene

mRNA expression in normal human tissues for SLC38A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC38A5 Gene

This gene is overexpressed in Pancreas (12.3) and Whole Blood (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC38A5 Gene

SOURCE GeneReport for Unigene cluster for SLC38A5 Gene Hs.195155

mRNA Expression by UniProt/SwissProt for SLC38A5 Gene

Q8WUX1-S38A5_HUMAN
Tissue specificity: Predominantly expressed in stomach, brain, liver, lung and intestinal tract.
genes like me logo Genes that share expressions with SLC38A5: view

In Situ Assay Products

Orthologs for SLC38A5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC38A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC38A5 35
  • 99.58 (n)
  • 99.79 (a)
SLC38A5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC38A5 35
  • 90.43 (n)
  • 90.85 (a)
SLC38A5 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC38A5 35
  • 87.27 (n)
  • 86.33 (a)
SLC38A5 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc38a5 35
  • 86.78 (n)
  • 88.06 (a)
Slc38a5 16
Slc38a5 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC38A5 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC38A5 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc38a5 35
  • 86.57 (n)
  • 88.27 (a)
chicken
(Gallus gallus)
Aves SLC38A5 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC38A5 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc38a5a 36
  • 59 (a)
OneToMany
slc38a5b 36
  • 64 (a)
OneToMany
Species with no ortholog for SLC38A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC38A5 Gene

ENSEMBL:
Gene Tree for SLC38A5 (if available)
TreeFam:
Gene Tree for SLC38A5 (if available)

Paralogs for SLC38A5 Gene

Paralogs for SLC38A5 Gene

Selected SIMAP similar genes for SLC38A5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC38A5: view

Variants for SLC38A5 Gene

Sequence variations from dbSNP and Humsavar for SLC38A5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs909322 -- 48,460,036(+) GTCTC(C/T)ATGTT intron-variant
rs2272657 -- 48,460,513(+) AAAAC(A/G)CTGCC intron-variant
rs2293951 -- 48,459,468(+) CCAGC(C/G)ATCCT intron-variant
rs2293952 -- 48,461,915(+) ATGTC(C/G)AATAT intron-variant
rs2293953 -- 48,467,829(+) ATCCT(A/G)ACCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC38A5 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680
esv267622 CNV Insertion 20981092

Relevant External Links for SLC38A5 Gene

HapMap Linkage Disequilibrium report
SLC38A5
Locus Specific Mutation Databases (LSDB)
SLC38A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC38A5 Gene

Disorders for SLC38A5 Gene

No disorders were found for SLC38A5 Gene.

No data available for UniProtKB/Swiss-Prot for SLC38A5 Gene

Publications for SLC38A5 Gene

  1. Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N. (PMID: 11243884) Nakanishi T. … Ganapathy V. (Biochem. Biophys. Res. Commun. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Loss of SLC38A5 and FTSJ1 at Xp11.23 in three brothers with non-syndromic mental retardation due to a microdeletion in an unstable genomic region. (PMID: 17333282) Froyen G. … Turner G. (Hum. Genet. 2007) 3
  5. Amino acid transport across mammalian intestinal and renal epithelia. (PMID: 18195088) BrAPer S. (Physiol. Rev. 2008) 3

Products for SLC38A5 Gene

  • antibodies-online peptides for SLC38A5
  • antibodies-online antibodies for SLC38A5
  • antibodies-online kits for SLC38A5

Sources for SLC38A5 Gene

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