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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC38A4 Gene

protein-coding   GIFtS: 54
GCID: GC12M047138

solute carrier family 38, member 4
 Explore 2 diseases affiliated with
SLC38A4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC38A4    

Aliases
for SLC38A4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 38, Member 41 2     Na(+)-Coupled Neutral Amino Acid Transporter 42 3
ATA31 2 3 5     Amino Acid Transporter System A32
NAT31 2 3 5     N Amino Acid Transporter 32
PAAT1 2     Sodium-Coupled Neutral Amino Acid Transporter 42
Amino Acid Transporter A32 3     SNAT43
System A Amino Acid Transporter 32 3     Solute Carrier Family 38 Member 43
System N Amino Acid Transporter 32 3     

External Ids:    HGNC: 146791   Entrez Gene: 550892   Ensembl: ENSG000001392097   OMIM: 6080655   UniProtKB: Q969I63   

Export aliases for SLC38A4 gene to outside databases

Previous GC identifers: GC12M046875 GC12M045444 GC12M044189


Summaries
for SLC38A4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC38A4:
SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic
amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH
dependent (Hatanaka et al., 2001 (PubMed 11342143)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6
Function: Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium
ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met.
May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is
pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5




Genomic Views
for SLC38A4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC38A4 gene promoter:
         Cdc5   Evi-1   YY1   C/EBPalpha   Nkx6-1   POU2F1   FOXO4   HSF2   POU2F1a   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC38A4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC38A4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC38A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13

SLC38A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC38A4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M047138:  view genomic region     (about GC identifiers)

Start:
 47,158,544 bp from pter      End:
 47,226,191 bp from pter
Size:
 67,648 bases      Orientation:
 minus strand

Proteins
for SLC38A4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6 (See protein sequence)
Recommended Name: Sodium-coupled neutral amino acid transporter 4  
Size: 547 amino acids; 60764 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A8K553

Explore the universe of human proteins at neXtProt for SLC38A4: NX_Q969I6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q969I6

    • SLC38A4 Protein expression data from MOPED and PaxDb:    About this image 
    SLC38A4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137296.1  NP_060488.2  

    ENSEMBL proteins: 
     ENSP00000389843   ENSP00000266579   ENSP00000448186   ENSP00000450071   ENSP00000448543  
    Reactome Protein details: Q969I6
    Human Recombinant Protein Products for SLC38A4: 
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    OriGene Custom Protein Services for SLC38A4 
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    Novus Biologicals SLC38A4 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC38A4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    SLC38A4 for ontologies           About GeneDecksing



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    Uscn Antibodies for SLC38A4
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    Assay Products for SLC38A4: 
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    Uscn ELISAs and CLIAs for SLC38A4

    Protein Domains /
    Families
    for SLC38A4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC38A4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR013057 AA_transpt_TM

    Graphical View of Domain Structure for InterPro Entry Q969I6

    ProtoNet protein and cluster: Q969I6

    1 Blocks protein family: IPB000517 Ribosomal protein L30

    UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6
    Similarity: Belongs to the amino acid/polyamine transporter 2 family


    Function
    for SLC38A4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S38A4_HUMAN, Q969I6
    Function: Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium
    ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met.
    May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is
    pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5
    Biophysicochemical properties: pH dependence: Optimum pH is 7.5-8.5;

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015171amino acid transmembrane transporter activity IEA--
    GO:0015293symporter activity IEA--
         
    SLC38A4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC38A4:
     Increased S DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC38A4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC38A4
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC38A4 (see all 24):
    hsa-miR-579 hsa-miR-3673 hsa-miR-429 hsa-miR-1271 hsa-miR-128 hsa-miR-342-3p hsa-miR-374a* hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: SLC38A4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC38A4 (see all 7)
    OriGene shRNA RFP: SLC38A4
    OriGene siRNA: SLC38A4
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    Sirion Biotech Custom design and validation of potent shRNA sequences against SLC38A4 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SLC38A4
    Sirion Biotech Customized adenovirus for overexpression of SLC38A4 
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A4


    Pathways & Interactions
    for SLC38A4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amino acid and oligopeptide SLC transporters
    		Amino acid and oligopeptide SLC transporters1.00
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    		Amino acid transport across the plasma membrane0.63
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for SLC38A4
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Amino acid and oligopeptide SLC transporters
    Amino acid transport across the plasma membrane
    Transport of inorganic cations/anions and amino acids/oligopeptides



    SLC38A4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC38A4

    5/6 Interacting proteins for SLC38A4 (Q969I63) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPD1P108093I2D: score=1 
    PIGTQ969N23I2D: score=1 
    RFC5P409373I2D: score=1 
    UBCP0CG483I2D: score=1 
    UBE2G2P606043I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003333amino acid transmembrane transport ----
    GO:0006811ion transport TAS--
    GO:0006814sodium ion transport IEA--
    GO:0006865amino acid transport TAS--
    GO:0055085transmembrane transport TAS--

    SLC38A4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC38A4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC38A4

    1 HMDB Compound for SLC38A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--
    Search CenterWatch for drugs/clinical trials and news about SLC38A4 / S38A4 

    Transcripts
    for SLC38A4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC38A4 gene (2 alternative transcripts): 
    NM_001143824.1  NM_018018.4  

    Unigene Cluster for SLC38A4:

    Solute carrier family 38, member 4
    Hs.446077  [show with all ESTs]
    Unigene Representative Sequence: NM_018018
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447411(uc001rpi.2 uc001rpj.2) ENST00000266579 ENST00000550670
    ENST00000547477(uc009zkl.2) ENST00000546940

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): SLC38A4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC38A4
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC38A4 (see all 24):
    hsa-miR-579 hsa-miR-3673 hsa-miR-429 hsa-miR-1271 hsa-miR-128 hsa-miR-342-3p hsa-miR-374a* hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: SLC38A4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC38A4 (see all 7)
    OriGene shRNA RFP: SLC38A4
    OriGene siRNA: SLC38A4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC38A4
    Sirion Biotech Custom design and validation of potent shRNA sequences against SLC38A4 
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC38A4 (NM_018018)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC38A4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC38A4 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC38A4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC38A4

    Additional cDNA sequence: 

    AB055003.1 AF193836.1 AF305814.1 AK291168.1 BC069819.1 BC101827.1 BC104913.1 

    4 DOTS entries:

    DT.92424569  DT.100787327  DT.100787325  DT.100787326 

    24/62 AceView cDNA sequences (see all 62):

    AB055003 AW204828 AF193836 BG568069 CB162716 CB164010 AW772290 CB068274 
    CA778351 AA680367 CD652538 CB154705 BX497211 AI536648 BX472148 BI714727 
    AU118969 BX951458 BX494249 CB155977 AL700295 BG617472 BQ051010 BG618784 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
    SP1:                    -                                                                                                                     
    SP2:                    -     -                                                                                                               
    SP3:                          -                                                                                                               
    SP4:                                                                                                                    -                     


    ECgene alternative splicing isoforms for SLC38A4

    Expression
    for SLC38A4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC38A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAACAATCAT
    SLC38A4 Expression
    About this image

    SLC38A4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    HeartMyocardiumCardiac FibroblastsEpicardium
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    LimbHindlimb Ventral MuscleLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC38A4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC38A4

    SOURCE GeneReport for Unigene cluster: Hs.446077

    UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6
    Tissue specificity: Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas.
    Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels

        SABiosciences Custom PCR Arrays for SLC38A4
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A4

    Orthologs
    for SLC38A4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC38A4 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC38A41 solute carrier family 38, member 4 76.21(n)
    77.98(a)    		   417809  NM_001199549.1  NP_001186478.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC38A46
    		 --
    		 76(a)
    		 1 ↔ 1
    		 5(53315416-53332657)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufd51c052 Transcribed sequence with moderate similarity to protein more 74(n)    BM095470.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G805101 transmembrane amino acid transporter-like protein 42.93(n)
    31.51(a)    		   844390  NM_106699.1  NP_565239.1 
    rice
    (Oryza sativa)    		 Liliopsida Os06g06447001 hypothetical protein 43.86(n)
    30.62(a)    		   4341650  NM_001064724.1  NP_001058189.1 


    ENSEMBL Gene Tree for SLC38A4 (if available)
    TreeFam Gene Tree for SLC38A4 (if available) 

    Paralogs
    for SLC38A4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC38A4 gene
    SLC38A62  SLC38A12  SLC38A22  SLC38A52  SLC38A112  SLC38A102  
    5 SIMAP similar genes for SLC38A4 using alignment to 4 protein entries:     S38A4_HUMAN (see all proteins):
    SLC38A6    SLC38A2    SLC38A3    SLC38A5    SLC38A1

    SLC38A4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC38A4
    PGOHUM00000250995


    Genomic Variants
    for SLC38A4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1054 NCBI SNPs in SLC38A4 are shown (see all 1054)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs24656131,2
    		C,F,A,H--44189206(-) TTTATG/AGTTAG 3 -- int19Minor allele frequency- A:0.14NS EA NA WA 774
    rs556426771,2
    		C,F--44189911(+) AGTGAT/ACTTAC 3 -- ut31 int11Minor allele frequency- A:0.03NA 120
    rs784464511,2
    		C--44190014(+) AGCAAG/AAATGA 3 -- ut31 int12Minor allele frequency- A:0.04NA 122
    rs789742111,2
    		C,F--44190089(+) NNNNGG/ACCAAT 3 -- ut31 int13Minor allele frequency- A:0.03WA NA EA 358
    rs803019021,2
    		F--44190243(+) AAGAAG/AAGCAT 3 -- ut31 int11Minor allele frequency- A:0.04EA 120
    rs25433391,2
    		H--44190711(+) TGTTGT/CTGCTC 3 -- ut31 int14Minor allele frequency- C:0.00NS EA 416
    rs768441291,2
    		--44191197(+) CCTGGG/ATAGAA 3 -- ut31 int11Minor allele frequency- A:0.01WA 118
    rs1170245671,2
    		C,F--44192688(+) NNNNCC/TGCTAG 3 -- int11Minor allele frequency- T:0.02NA 120
    rs47687571,2
    		A--44193504(+) AGATTG/TTGTTT 3 -- int10--------
    rs65826761,2
    		C,F,A,H--44193893(+) AATCCA/GTGAGC 3 -- int19Minor allele frequency- G:0.16NS EA NA WA 800

    HapMap Linkage Disequilibrium report for SLC38A4 (47158544 - 47226191 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SLC38A4
         2 CNVs: 22994 101508

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    Disorders / Diseases
    for SLC38A4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC38A4 for disorders           About GeneDecksing

    OMIM gene information: 608065    OMIM disorders: --

    2 diseases for SLC38A4:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma

    1 disease from the University of Copenhagen DISEASES database for SLC38A4:
    Tricuspid valve insufficiency
    Human Genome Epidemiology (HuGE) Navigator: SLC38A4 (1 document)

    Export disorders for SLC38A4 gene to outside databases

    Publications
    for SLC38A4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC38A4 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SLC38A4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human amino acid transporter, hNAT3: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization. (PubMed id 11414754)1, 2, 3 Gu S.... Jiang J.X. (2001)
    2. Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. (PubMed id 11342143)1, 2, 9 Hatanaka T.... Ganapathy V. (2001)
    3. Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein. (PubMed id 21917917)1, 2 Shi Q.... Jiang J.X. (2011)
    4. SNAT4 isoform of system A amino acid transporter is expressed in human placenta. (PubMed id 16148032)1, 2 Desforges M.... Sibley C.P. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. (PubMed id 12845534)1, 2 Mackenzie B. and Erickson J.D. (2004)
    8. Amino acid transport systems beta and A in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. (PubMed id 18703994)1 Iruloh C.G....Glazier J.D. (2009)
    9. The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane. (PubMed id 19015196)1 Desforges M....Glazier J.D. (2009)
    10. Amino acid transport across mammalian intestinal and renal epithelia. (PubMed id 18195088)1 BrAPer S. (2008)

    External Searches for SLC38A4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing SLC38A4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55089 HGNC: 14679 AceView: SLC38A4 Ensembl:ENSG00000139209 euGenes: HUgn55089
    ECgene: SLC38A4 H-InvDB: SLC38A4

    Other Databases showing SLC38A4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC38A4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC38A4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC38A4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC38A4 gene:
    Search GeneIP for patents involving SLC38A4

    GeneCards and IP:
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