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SLC38A4 Gene

protein-coding   GIFtS: 55
GCID: GC12M047138

Solute Carrier Family 38, Member 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 38, Member 41 2     PAAT2
ATA32 3 5     Amino Acid Transporter System A32
NAT32 3 5     N Amino Acid Transporter 32
Amino Acid Transporter A32 3     Sodium-Coupled Neutral Amino Acid Transporter 42
System A Amino Acid Transporter 32 3     SNAT43
System N Amino Acid Transporter 32 3     Solute Carrier Family 38 Member 43
Na(+)-Coupled Neutral Amino Acid Transporter 42 3     

External Ids:    HGNC: 146791   Entrez Gene: 550892   Ensembl: ENSG000001392097   OMIM: 6080655   UniProtKB: Q969I63   

Export aliases for SLC38A4 gene to outside databases

Previous GC identifers: GC12M046875 GC12M045444 GC12M044189


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC38A4 Gene:
SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of
cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+)
and pH dependent (Hatanaka et al., 2001 (PubMed 11342143)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC38A4 Gene:
SLC38A4 (solute carrier family 38, member 4) is a protein-coding gene. Diseases associated with SLC38A4 include tricuspid valve insufficiency, and intrahepatic cholangiocarcinoma. GO annotations related to this gene include amino acid transmembrane transporter activity and symporter activity. An important paralog of this gene is SLC38A6.

UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6
Function: Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium
ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and
Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is
pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC38A4 gene promoter:
         Cdc5   Evi-1   YY1   C/EBPalpha   Nkx6-1   POU2F1   FOXO4   HSF2   POU2F1a   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC38A4 promoter sequence
   Search Chromatin IP Primers for SLC38A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC38A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13

SLC38A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC38A4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M047138:  view genomic region     (about GC identifiers)

Start:
47,158,544 bp from pter      End:
47,226,191 bp from pter
Size:
67,648 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6 (See protein sequence)
Recommended Name: Sodium-coupled neutral amino acid transporter 4  
Size: 547 amino acids; 60764 Da
Secondary accessions: A8K553

Explore the universe of human proteins at neXtProt for SLC38A4: NX_Q969I6

Explore proteomics data for SLC38A4 at MOPED

Post-translational modifications: 

  • The disulfide bond plays an important role in substrate transport, but has no effect on trafficking to the cell
    surface (By similarity)1
  • Glycosylation2 at Asn260, Asn264, Asn276
  • Modification sites at PhosphoSitePlus

  • See SLC38A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137296.1  NP_060488.2  

    ENSEMBL proteins: 
     ENSP00000389843   ENSP00000266579   ENSP00000448186   ENSP00000450071   ENSP00000448543  
    Reactome Protein details: Q969I6

    SLC38A4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SNAT4
    System A-like transporters

    1 InterPro protein domain:
     IPR013057 AA_transpt_TM

    Graphical View of Domain Structure for InterPro Entry Q969I6

    ProtoNet protein and cluster: Q969I6

    1 Blocks protein domain: IPB000517 Ribosomal protein L30

    UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6
    Similarity: Belongs to the amino acid/polyamine transporter 2 family


    SLC38A4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S38A4_HUMAN, Q969I6
    Function: Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium
    ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and
    Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is
    pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5
    Biophysicochemical properties: pH dependence: Optimum pH is 7.5-8.5;

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015171amino acid transmembrane transporter activity IEA--
    GO:0015293symporter activity IEA--
         
    SLC38A4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC38A4:
     Increased S DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC38A4
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    miRNA
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    miRTarBase miRNAs that target SLC38A4:
    hsa-mir-335-5p (MIRT017627)

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    Selected qRT-PCR Assays for microRNAs that regulate SLC38A4 (see all 24):
    hsa-miR-579 hsa-miR-3673 hsa-miR-429 hsa-miR-1271 hsa-miR-128 hsa-miR-342-3p hsa-miR-374a* hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidSLC38A4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S38A4_HUMAN, Q969I6: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    SLC38A4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC38A4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Amino acid transport across the plasma membrane0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC38A4
        Amino acid transport across the plasma membrane



    SLC38A4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC38A4
    Interactions:

        Search GeneGlobe Interaction Network for SLC38A4

    Selected Interacting proteins for SLC38A4 (Q969I63) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPD1P108093I2D: score=1 
    PIGTQ969N23I2D: score=1 
    RFC5P409373I2D: score=1 
    UBCP0CG483I2D: score=1 
    UBE2G2P606043I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003333amino acid transmembrane transport ----
    GO:0006811ion transport TAS--
    GO:0006814sodium ion transport IEA--
    GO:0006865amino acid transport TAS--
    GO:0055085transmembrane transport TAS--

    SLC38A4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC38A4 (S38A4)

    1 HMDB Compound for SLC38A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    4 IUPHAR Ligands for SLC38A4 (SNAT4)    About this table
    LigandTypeActionAffinityPubmed IDs
    [14C]glycine
    NoneNone--
    [3H]alanine
    NoneNone--
    [3H]glycine
    NoneNone--
    [14C]alanine
    NoneNone--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC38A4 gene (2 alternative transcripts): 
    NM_001143824.1  NM_018018.4  

    Unigene Cluster for SLC38A4:

    Solute carrier family 38, member 4
    Hs.446077  [show with all ESTs]
    Unigene Representative Sequence: NM_018018
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447411(uc001rpi.2 uc001rpj.2) ENST00000266579 ENST00000550670
    ENST00000547477(uc009zkl.2) ENST00000546940
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC38A4 (see all 24):
    hsa-miR-579 hsa-miR-3673 hsa-miR-429 hsa-miR-1271 hsa-miR-128 hsa-miR-342-3p hsa-miR-374a* hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidSLC38A4 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC38A4
      QuantiFast Probe-based Assays in human, mouse, rat SLC38A4

    Additional mRNA sequence: 

    AB055003.1 AF193836.1 AF305814.1 AK291168.1 BC069819.1 BC101827.1 BC104913.1 

    4 DOTS entries:

    DT.92424569  DT.100787327  DT.100787325  DT.100787326 

    Selected AceView cDNA sequences (see all 62):

    CB162716 AA680367 CA778351 CB164010 AW204828 BG568069 AW772290 AB055003 
    AF193836 CB068274 BG290858 BG618592 CA950937 AK001053 AA705032 BG533486 
    CB155977 CD652538 BX951458 BX283789 CA778277 BX472148 BE463522 BX494249 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
    SP1:                    -                                                                                                                     
    SP2:                    -     -                                                                                                               
    SP3:                          -                                                                                                               
    SP4:                                                                                                                    -                     


    ECgene alternative splicing isoforms for SLC38A4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC38A4 expression in normal human tissues (normalized intensities)      SLC38A4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACAATCAT
    SLC38A4 Expression
    About this image


    SLC38A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocyte-like cells
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocyte-like cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
    SLC38A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC38A4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446077

    UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6
    Tissue specificity: Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and
    pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC38A4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc38a41 , 5 solute carrier family 38, member 41, 5 82.51(n)1
    87.02(a)1
      15 (52.77 cM)5
    693541  NM_027052.31  NP_081328.21 
     969948235 
    chicken
    (Gallus gallus)
    Aves SLC38A41 solute carrier family 38, member 4 76.21(n)
    77.98(a)
      417809  NM_001199549.1  NP_001186478.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC38A46
    solute carrier family 38, member 4
    76(a)
    1 ↔ 1
    5(53305995-53336494)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1001452091 uncharacterized LOC100145209 71.48(n)
    73.73(a)
      100145209  NM_001126697.1  NP_001120169.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd51c052 Transcribed sequence with moderate similarity to protein more 74(n)    BM095470.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G805101 AT1G80510 43.24(n)
    32.24(a)
      844390  NM_106699.1  NP_565239.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06447001 Os06g0644700 43.86(n)
    30.62(a)
      4341650  NM_001064724.1  NP_001058189.1 


    ENSEMBL Gene Tree for SLC38A4 (if available)
    TreeFam Gene Tree for SLC38A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC38A4 gene
    SLC38A62  SLC38A12  SLC38A22  SLC38A52  SLC38A112  SLC38A102  
    5 SIMAP similar genes for SLC38A4 using alignment to 4 protein entries:     S38A4_HUMAN (see all proteins):
    SLC38A6    SLC38A2    SLC38A3    SLC38A5    SLC38A1

    SLC38A4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC38A4
    PGOHUM00000250995


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for SLC38A4    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs111836101,2,4
    ----see VAR_0481242 mis40--------
    rs24294671,2,4
    ----see VAR_0481232 mis40--------

    HapMap Linkage Disequilibrium report for SLC38A4 (47158544 - 47226191 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC38A4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv435639CNV Deletion17901297
    esv2607065CNV Deletion19546169
    esv2745849CNV Deletion23290073
    nsv826361CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC38A4
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC38A4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608065    OMIM disorders: --

    6 diseases for SLC38A4:    About MalaCards
    tricuspid valve insufficiency    intrahepatic cholangiocarcinoma    cholangiocarcinoma    prostate cancer
    endotheliitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SLC38A4:
    Tricuspid valve insufficiency

    SLC38A4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC38A4
    Human Genome Epidemiology (HuGE) Navigator: SLC38A4 (1 document)

    Export disorders for SLC38A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC38A4 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with SLC38A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human amino acid transporter, hNAT3: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization. (PubMed id 11414754)1, 2, 3 Gu S.... Jiang J.X. (Genomics 2001)
    2. Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. (PubMed id 11342143)1, 2, 9 Hatanaka T.... Ganapathy V. (Biochim. Biophys. Acta 2001)
    3. Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein. (PubMed id 21917917)1, 2 Shi Q.... Jiang J.X. (J. Biol. Chem. 2011)
    4. SNAT4 isoform of system A amino acid transporter is expressed in human placenta. (PubMed id 16148032)1, 2 Desforges M.... Sibley C.P. (Am. J. Physiol. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. (PubMed id 12845534)1, 2 Mackenzie B. and Erickson J.D. (Pflugers Arch. 2004)
    8. Association of the polymorphisms 292a88C&gt;T and 1304a88G&gt;A in the SLC38A4 gene with hyperglycaemia. (PubMed id 22945694)1 GonzA!lez-Renteria S.M....Galaviz-HernA!ndez C. (Diabetes Metab. Res. Rev. 2013)
    9. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)4 Tao S....Sun J. (Carcinogenesis 2012)
    10. Amino acid transport systems beta and A in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. (PubMed id 18703994)1 Iruloh C.G....Glazier J.D. (Pediatr. Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55089 HGNC: 14679 AceView: SLC38A4 Ensembl:ENSG00000139209 euGenes: HUgn55089
    ECgene: SLC38A4 H-InvDB: SLC38A4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC38A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC38A4 gene:
    Search GeneIP for patents involving SLC38A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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