Aliases for SLC38A4 Gene
External Ids for SLC38A4 Gene
Previous GeneCards Identifiers for SLC38A4 Gene
SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SLC38A4 Gene
SLC38A4 (Solute Carrier Family 38, Member 4) is a Protein Coding gene. Diseases associated with SLC38A4 include tricuspid valve insufficiency. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include symporter activity and amino acid transmembrane transporter activity. An important paralog of this gene is SLC38A1.
UniProtKB/Swiss-Prot for SLC38A4 Gene
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.