Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC38A4 Gene

Aliases for SLC38A4 Gene

  • Solute Carrier Family 38 Member 4 2 3 4 5
  • Na(+)-Coupled Neutral Amino Acid Transporter 4 3 4
  • Solute Carrier Family 38, Member 4 2 3
  • System A Amino Acid Transporter 3 3 4
  • System N Amino Acid Transporter 3 3 4
  • Amino Acid Transporter A3 3 4
  • SNAT4 3 4
  • NAT3 3 4
  • ATA3 3 4
  • Amino Acid Transporter System A3 3
  • N Amino Acid Transporter 3 3
  • PAAT 3

External Ids for SLC38A4 Gene

Previous GeneCards Identifiers for SLC38A4 Gene

  • GC12M047138
  • GC12M046875
  • GC12M045444
  • GC12M044189

Summaries for SLC38A4 Gene

Entrez Gene Summary for SLC38A4 Gene

  • SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC38A4 Gene

SLC38A4 (Solute Carrier Family 38 Member 4) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include symporter activity and amino acid transmembrane transporter activity. An important paralog of this gene is SLC38A1.

UniProtKB/Swiss-Prot for SLC38A4 Gene

  • Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A4 Gene

Genomics for SLC38A4 Gene

Regulatory Elements for SLC38A4 Gene

Promoters for SLC38A4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC38A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC38A4 Gene

Chromosome:
12
Start:
46,764,761 bp from pter
End:
46,832,422 bp from pter
Size:
67,662 bases
Orientation:
Minus strand

Genomic View for SLC38A4 Gene

Genes around SLC38A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC38A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC38A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A4 Gene

Proteins for SLC38A4 Gene

  • Protein details for SLC38A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969I6-S38A4_HUMAN
    Recommended name:
    Sodium-coupled neutral amino acid transporter 4
    Protein Accession:
    Q969I6
    Secondary Accessions:
    • A8K553

    Protein attributes for SLC38A4 Gene

    Size:
    547 amino acids
    Molecular mass:
    60764 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC38A4 Gene

Proteomics data for SLC38A4 Gene at MOPED

Post-translational modifications for SLC38A4 Gene

  • The disulfide bond plays an important role in substrate transport, but has no effect on trafficking to the cell surface.
  • Glycosylation at Asn 260, Asn 264, and Asn 276
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC38A4 Gene

Antibody Products

No data available for DME Specific Peptides for SLC38A4 Gene

Domains & Families for SLC38A4 Gene

Gene Families for SLC38A4 Gene

Protein Domains for SLC38A4 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC38A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969I6

UniProtKB/Swiss-Prot:

S38A4_HUMAN :
  • Belongs to the amino acid/polyamine transporter 2 family.
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A4: view

Function for SLC38A4 Gene

Molecular function for SLC38A4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.5-8.5. {ECO:0000269 PubMed:11342143};
UniProtKB/Swiss-Prot Function:
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.
genes like me logo Genes that share phenotypes with SLC38A4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC38A4

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC38A4 Gene

Localization for SLC38A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC38A4 Gene COMPARTMENTS Subcellular localization image for SLC38A4 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SLC38A4 Gene

Pathways & Interactions for SLC38A4 Gene

genes like me logo Genes that share pathways with SLC38A4: view

Interacting Proteins for SLC38A4 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000266579%0d%0a9606.ENSP00000243389%0d%0a9606.ENSP00000317382%0d%0a9606.ENSP00000334223%0d%0a9606.ENSP00000366942%0d%0a9606.ENSP00000254181%0d%0a
Selected Interacting proteins: Q969I6-S38A4_HUMAN ENSP00000266579 for SLC38A4 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SLC38A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC38A4: view

No data available for SIGNOR curated interactions for SLC38A4 Gene

Drugs & Compounds for SLC38A4 Gene

(4) Drugs for SLC38A4 Gene - From: IUPHAR and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>14</sup>C]alanine Pharma 0
[<sup>14</sup>C]glycine Pharma 0
[<sup>3</sup>H]alanine Pharma 0
[<sup>3</sup>H]glycine Pharma 0

(1) Additional Compounds for SLC38A4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC38A4: view

Transcripts for SLC38A4 Gene

Unigene Clusters for SLC38A4 Gene

Solute carrier family 38, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP1: -
SP2: - -
SP3: -
SP4: -

Relevant External Links for SLC38A4 Gene

GeneLoc Exon Structure for
SLC38A4
ECgene alternative splicing isoforms for
SLC38A4

Expression for SLC38A4 Gene

mRNA expression in normal human tissues for SLC38A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC38A4 Gene

This gene is overexpressed in Liver (x43.2).

Protein differential expression in normal tissues from HIPED for SLC38A4 Gene

This gene is overexpressed in Brain (41.4), Liver (17.5), and Fetal Liver (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC38A4 Gene



SOURCE GeneReport for Unigene cluster for SLC38A4 Gene Hs.446077

mRNA Expression by UniProt/SwissProt for SLC38A4 Gene

Q969I6-S38A4_HUMAN
Tissue specificity: Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels.
genes like me logo Genes that share expression patterns with SLC38A4: view

Protein tissue co-expression partners for SLC38A4 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC38A4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC38A4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC38A4 35
  • 91.53 (n)
  • 93.6 (a)
ATA3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC38A4 35
  • 92.44 (n)
  • 94.52 (a)
SLC38A4 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc38a4 35
  • 82.51 (n)
  • 87.02 (a)
Slc38a4 16
Slc38a4 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC38A4 35
  • 99.57 (n)
  • 99.27 (a)
SLC38A4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc38a4 35
  • 83.24 (n)
  • 88.12 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC38A4 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC38A4 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC38A4 35
  • 76.21 (n)
  • 77.98 (a)
SLC38A4 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC38A4 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145209 35
  • 71.48 (n)
  • 73.73 (a)
zebrafish
(Danio rerio)
Actinopterygii slc38a4 35
  • 66.42 (n)
  • 70.24 (a)
wufd51c05 35
slc38a4 36
  • 68 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G80510 35
  • 43.24 (n)
  • 32.24 (a)
rice
(Oryza sativa)
Liliopsida Os06g0644700 35
  • 43.86 (n)
  • 30.62 (a)
Species with no ortholog for SLC38A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC38A4 Gene

ENSEMBL:
Gene Tree for SLC38A4 (if available)
TreeFam:
Gene Tree for SLC38A4 (if available)

Paralogs for SLC38A4 Gene

Paralogs for SLC38A4 Gene

(5) SIMAP similar genes for SLC38A4 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SLC38A4 Gene

genes like me logo Genes that share paralogs with SLC38A4: view

Variants for SLC38A4 Gene

Sequence variations from dbSNP and Humsavar for SLC38A4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2429467 - 46,792,987(+) TATCC(C/T)GATGT reference, missense
rs11183610 - 46,776,981(+) ACACC(A/G)TTTGC reference, missense
rs180403 -- 46,769,523(+) CTTTC(C/T)TTTTC intron-variant
rs180404 -- 46,770,034(+) TTGGC(C/G)TATTT intron-variant
rs180405 -- 46,770,335(-) AAACA(C/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC38A4 Gene

Variant ID Type Subtype PubMed ID
nsv826361 CNV Loss 20364138
esv2607065 CNV Deletion 19546169
nsv435639 CNV Deletion 17901297
esv2745849 CNV Deletion 23290073

Variation tolerance for SLC38A4 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.92; 79.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC38A4 Gene

HapMap Linkage Disequilibrium report
SLC38A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC38A4 Gene

Disorders for SLC38A4 Gene

Relevant External Links for SLC38A4

Genetic Association Database (GAD)
SLC38A4
Human Genome Epidemiology (HuGE) Navigator
SLC38A4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC38A4

No disorders were found for SLC38A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC38A4 Gene

Publications for SLC38A4 Gene

  1. A novel human amino acid transporter, hNAT3: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization. (PMID: 11414754) Gu S. … Jiang J.X. (Genomics 2001) 2 3 4 67
  2. Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. (PMID: 11342143) Hatanaka T. … Ganapathy V. (Biochim. Biophys. Acta 2001) 3 23
  3. PAAT, a novel ATPase and trans-regulator of mitochondrial ABC transporters, is critically involved in the maintenance of mitochondrial homeostasis. (PMID: 25063848) Yang X. … Liang J. (FASEB J. 2014) 3
  4. Association of the polymorphisms 292a88C&amp;gt;T and 1304a88G&amp;gt;A in the SLC38A4 gene with hyperglycaemia. (PMID: 22945694) GonzA!lez-Renteria S.M. … Galaviz-HernA!ndez C. (Diabetes Metab. Res. Rev. 2013) 3
  5. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. (PMID: 23506890) SchiAPth H.B. … Fredriksson R. (Mol. Aspects Med. 2013) 3

Products for SLC38A4 Gene

Sources for SLC38A4 Gene

Back to Top

Content