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Aliases for SLC38A3 Gene

Aliases for SLC38A3 Gene

  • Solute Carrier Family 38 Member 3 2 3 4 5
  • Na(+)-Coupled Neutral Amino Acid Transporter 3 3 4
  • System N Amino Acid Transporter 1 3 4
  • N-System Amino Acid Transporter 1 3 4
  • SNAT3 3 4
  • NAT1 3 4
  • G17 3 4
  • SN1 3 4
  • System N1 Na+ And H+-Coupled Glutamine Transporter 3
  • Sodium-Coupled Neutral Amino Acid Transporter 3 3
  • Solute Carrier Family 38, Member 3 2

External Ids for SLC38A3 Gene

Previous GeneCards Identifiers for SLC38A3 Gene

  • GC03M049728
  • GC03M049898
  • GC03P050097
  • GC03P050201
  • GC03P050217
  • GC03P050244

Summaries for SLC38A3 Gene

GeneCards Summary for SLC38A3 Gene

SLC38A3 (Solute Carrier Family 38 Member 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Circadian entrainment. GO annotations related to this gene include symporter activity and L-alanine transmembrane transporter activity. An important paralog of this gene is SLC38A5.

UniProtKB/Swiss-Prot for SLC38A3 Gene

  • Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.

Gene Wiki entry for SLC38A3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A3 Gene

Genomics for SLC38A3 Gene

Regulatory Elements for SLC38A3 Gene

Enhancers for SLC38A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F050201 1.3 FANTOM5 ENCODE 7.6 -1.2 -1156 4.8 ARID4B DMAP1 ZNF48 YY1 SP3 SP5 NFYC JUNB MXD4 MIER2 RBM6 GNAI2 MIR6872 SEMA3B SEMA3B-AS1 LSMEM2 CYB561D2 HYAL3 SEMA3F SEMA3F-AS1
GH03F050208 1.1 FANTOM5 0.8 +3.8 3782 0.3 HDGF ATF1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 GLIS2 HYAL1 SEMA3B SLC38A3 GNAI2
GH03F050192 1.3 Ensembl ENCODE 0.4 -10.8 -10762 4.4 PKNOX1 ARID4B FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS SP5 RBM6 HYAL3 GNAI2 SEMA3F SEMA3F-AS1 SEMA3B SEMA3B-AS1 MIR6872 LSMEM2 HYAL1
GH03F050210 1 ENCODE 0.4 +5.6 5570 1.5 PKNOX1 MLX ZFP64 DMAP1 ZNF48 YY1 SP5 MXD4 PPARG KAT8 RBM6 DOCK3 SLC38A3 GNAI2
GH03F050221 1.1 Ensembl ENCODE 0.3 +16.4 16417 1.3 ELF3 HDGF ARID4B DMAP1 THRB ZNF48 RAD21 RARA GLIS2 SCRT2 CYB561D2 MST1 GNAI2 SLC38A3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC38A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC38A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001363833 154 801 HDAC1 CTCF KLF1 SUZ12 SAP130 ARID4B ZNF48 ZIC2 ZKSCAN1 YY1

Genomic Location for SLC38A3 Gene

Chromosome:
3
Start:
50,205,246 bp from pter
End:
50,221,486 bp from pter
Size:
16,241 bases
Orientation:
Plus strand

Genomic View for SLC38A3 Gene

Genes around SLC38A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC38A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC38A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A3 Gene

Proteins for SLC38A3 Gene

  • Protein details for SLC38A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99624-S38A3_HUMAN
    Recommended name:
    Sodium-coupled neutral amino acid transporter 3
    Protein Accession:
    Q99624
    Secondary Accessions:
    • B2R8Q0
    • Q6IB34

    Protein attributes for SLC38A3 Gene

    Size:
    504 amino acids
    Molecular mass:
    55773 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC38A3 Gene

Post-translational modifications for SLC38A3 Gene

  • Glycosylation at Asn 74, Asn 247, Asn 248, Asn 252, and Asn 323
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC38A3 Gene

Antibody Products

  • Abcam antibodies for SLC38A3

No data available for DME Specific Peptides for SLC38A3 Gene

Domains & Families for SLC38A3 Gene

Gene Families for SLC38A3 Gene

Protein Domains for SLC38A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC38A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99624

UniProtKB/Swiss-Prot:

S38A3_HUMAN :
  • Belongs to the amino acid/polyamine transporter 2 family.
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A3: view

Function for SLC38A3 Gene

Molecular function for SLC38A3 Gene

UniProtKB/Swiss-Prot Function:
Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.

Gene Ontology (GO) - Molecular Function for SLC38A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005290 L-histidine transmembrane transporter activity IDA 10823827
GO:0015171 amino acid transmembrane transporter activity TAS --
GO:0015180 L-alanine transmembrane transporter activity IDA 10823827
GO:0015182 L-asparagine transmembrane transporter activity IDA 10823827
GO:0015186 L-glutamine transmembrane transporter activity IDA 10823827
genes like me logo Genes that share ontologies with SLC38A3: view
genes like me logo Genes that share phenotypes with SLC38A3: view

Animal Model Products

miRNA for SLC38A3 Gene

miRTarBase miRNAs that target SLC38A3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC38A3 Gene

Localization for SLC38A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A3 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SLC38A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC38A3: view

No data available for Subcellular locations from COMPARTMENTS for SLC38A3 Gene

Pathways & Interactions for SLC38A3 Gene

genes like me logo Genes that share pathways with SLC38A3: view

Interacting Proteins for SLC38A3 Gene

Selected Interacting proteins: Q99624-S38A3_HUMAN for SLC38A3 Gene via IID

Gene Ontology (GO) - Biological Process for SLC38A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006865 amino acid transport TAS --
GO:0006867 asparagine transport IDA 10823827
genes like me logo Genes that share ontologies with SLC38A3: view

No data available for SIGNOR curated interactions for SLC38A3 Gene

Drugs & Compounds for SLC38A3 Gene

(7) Drugs for SLC38A3 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved Nutra Target 0
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Transporter, substrate 0
L-Histidine Approved Nutra Target 0
L-Alanine Approved Nutra Full agonist, Agonist Glycine receptor agonist 0
[<sup>14</sup>C]glutamine Pharma 0

(1) Additional Compounds for SLC38A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC38A3: view

Transcripts for SLC38A3 Gene

Unigene Clusters for SLC38A3 Gene

Solute carrier family 38, member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - -
SP2:
SP3: - - -
SP4:
SP5:
SP6:

Relevant External Links for SLC38A3 Gene

GeneLoc Exon Structure for
SLC38A3
ECgene alternative splicing isoforms for
SLC38A3

Expression for SLC38A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC38A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC38A3 Gene

This gene is overexpressed in Liver (x23.8) and Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for SLC38A3 Gene

This gene is overexpressed in Fetal Liver (23.3), Frontal cortex (16.0), Liver (10.9), and Retina (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC38A3 Gene



Protein tissue co-expression partners for SLC38A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC38A3 Gene:

SLC38A3

SOURCE GeneReport for Unigene cluster for SLC38A3 Gene:

Hs.76460
genes like me logo Genes that share expression patterns with SLC38A3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC38A3 Gene

Orthologs for SLC38A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC38A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC38A3 34
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia SLC38A3 34
  • 90.54 (n)
cow
(Bos Taurus)
Mammalia SLC38A3 34
  • 89.09 (n)
rat
(Rattus norvegicus)
Mammalia Slc38a3 34
  • 87.81 (n)
mouse
(Mus musculus)
Mammalia Slc38a3 34 16
  • 87.21 (n)
chicken
(Gallus gallus)
Aves SLC38A3 34
  • 78.33 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc38a3 34
  • 72.45 (n)
zebrafish
(Danio rerio)
Actinopterygii slc38a5b 34
  • 65.73 (n)
wufc48a10 34
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G38820 34
  • 41.05 (n)
rice
(Oryza sativa)
Liliopsida Os06g0275800 34
  • 44.68 (n)
Species where no ortholog for SLC38A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC38A3 Gene

ENSEMBL:
Gene Tree for SLC38A3 (if available)
TreeFam:
Gene Tree for SLC38A3 (if available)

Paralogs for SLC38A3 Gene

Paralogs for SLC38A3 Gene

(5) SIMAP similar genes for SLC38A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC38A3: view

Variants for SLC38A3 Gene

Sequence variations from dbSNP and Humsavar for SLC38A3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs111262547 -- 50,221,008(+) ATGGT(A/C)CCTGG downstream-variant-500B
rs111410639 -- 50,211,675(+) CCTCC(A/C)CCTCC intron-variant
rs111930245 -- 50,213,409(+) TGGCC(C/G)TGGAG intron-variant
rs112189294 -- 50,213,778(+) CCAGA(A/G)TGAAG intron-variant
rs112357700 -- 50,210,352(+) GTCTC(C/T)CTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC38A3 Gene

Variant ID Type Subtype PubMed ID
nsv515986 CNV loss 19592680
nsv523560 CNV loss 19592680
nsv523662 CNV loss 19592680
nsv590255 CNV loss 21841781
nsv834690 CNV loss 17160897
nsv834692 CNV loss 17160897
nsv954855 CNV deletion 24416366
nsv470561 CNV loss 18288195
nsv460531 CNV loss 19166990
esv3596139 CNV loss 21293372
esv3381149 CNV insertion 20981092
esv2759148 CNV loss 17122850
dgv8317n54 CNV loss 21841781
dgv8316n54 CNV loss 21841781
dgv602n27 CNV loss 19166990

Relevant External Links for SLC38A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC38A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SLC38A3 Gene

Disorders for SLC38A3 Gene

Relevant External Links for SLC38A3

Genetic Association Database (GAD)
SLC38A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC38A3

No disorders were found for SLC38A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC38A3 Gene

Publications for SLC38A3 Gene

  1. Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+- coupled glutamine transporter. (PMID: 10823827) Fei Y.-J. … Ganapathy V. (J. Biol. Chem. 2000) 2 3 4 64
  2. Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. (PMID: 10619430) Chaudhry F.A. … Edwards R.H. (Cell 1999) 2 3 22 64
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 64
  4. Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice. (PMID: 16432833) Kholodnyuk I.D. … Imreh S. (Int. J. Cancer 2006) 3 22 64
  5. Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas. (PMID: 15094455) Sidoryk M. … Albrecht J. (Neuroreport 2004) 3 22 64

Products for SLC38A3 Gene

Sources for SLC38A3 Gene

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