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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC38A3 Gene

protein-coding   GIFtS: 54
GCID: GC03P050244

Solute Carrier Family 38, Member 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 38, Member 31 2     Na(+)-Coupled Neutral Amino Acid Transporter 32 3
G172 3 5     Sodium-Coupled Neutral Amino Acid Transporter 32
SN12 3 5     System N1 Na+ And H+-Coupled Glutamine Transporter2
System N Amino Acid Transporter 12 3     SNAT33
NAT12 3     Solute Carrier Family 38 Member 33
N-System Amino Acid Transporter 12 3     

External Ids:    HGNC: 180441   Entrez Gene: 109912   Ensembl: ENSG000001883387   OMIM: 6044375   UniProtKB: Q996243   

Export aliases for SLC38A3 gene to outside databases

Previous GC identifers: GC03M049728 GC03M049898 GC03P050097 GC03P050201 GC03P050217


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC38A3 Gene: 
SLC38A3 (solute carrier family 38, member 3) is a protein-coding gene. Diseases associated with SLC38A3 include severe combined immunodeficiency, and malignant glioma, and among its related super-pathways are Amino acid transport across the plasma membrane and Morphine addiction. GO annotations related to this gene include L-alanine transmembrane transporter activity and symporter activity.

UniProtKB/Swiss-Prot: S38A3_HUMAN, Q99624
Function: Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium
ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport
in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic
transmission

Gene Wiki entry for SLC38A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC38A3 gene promoter:
         Egr-3   Pbx1a   p53   NF-AT   C/EBPalpha   GATA-2   c-Ets-1   HOXA5   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC38A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC38A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC38A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

SLC38A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC38A3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050244:  view genomic region     (about GC identifiers)

Start:
50,242,679 bp from pter      End:
50,258,411 bp from pter
Size:
15,733 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S38A3_HUMAN, Q99624 (See protein sequence)
Recommended Name: Sodium-coupled neutral amino acid transporter 3  
Size: 504 amino acids; 55773 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: B2R8Q0 Q6IB34

Explore the universe of human proteins at neXtProt for SLC38A3: NX_Q99624

Explore proteomics data for SLC38A3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99624

  • SLC38A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC38A3 Protein Expression
    REFSEQ proteins: NP_006832.1  Reactome Protein details: Q99624
    Human Recombinant Protein Products for SLC38A3: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane ISS--

    SLC38A3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SNAT3 
    System N-like transporters

    1 InterPro protein domain:
     IPR013057 AA_transpt_TM

    Graphical View of Domain Structure for InterPro Entry Q99624

    ProtoNet protein and cluster: Q99624

    UniProtKB/Swiss-Prot: S38A3_HUMAN, Q99624
    Similarity: Belongs to the amino acid/polyamine transporter 2 family


    SLC38A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S38A3_HUMAN, Q99624
    Function: Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium
    ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport
    in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic
    transmission

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005290L-histidine transmembrane transporter activity IDA10823827
    GO:0015180L-alanine transmembrane transporter activity IDA10823827
    GO:0015182L-asparagine transmembrane transporter activity IDA10823827
    GO:0015186L-glutamine transmembrane transporter activity IDA10823827
    GO:0015293symporter activity IEA--
         
    SLC38A3 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC38A3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Amino acid and oligopeptide SLC transporters
    Amino acid and oligopeptide SLC transporters0.63
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    Amino acid transport across the plasma membrane0.63
    2Circadian entrainment
    GABAergic synapse0.53
    Glutamatergic synapse0.39
    3SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    4Proximal tubule bicarbonate reclamation
    Proximal tubule bicarbonate reclamation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for SLC38A3
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Amino acid and oligopeptide SLC transporters
    Amino acid transport across the plasma membrane
    Transport of inorganic cations/anions and amino acids/oligopeptides


    3         Kegg Pathways  (Kegg details for SLC38A3):
        Glutamatergic synapse
    GABAergic synapse
    Proximal tubule bicarbonate reclamation


    SLC38A3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC38A3

    2 Interacting proteins for SLC38A3 (Q996242, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SETDB1Q150472, 3MINT-65284 I2D: score=5 
    NEDD4P469343I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006814sodium ion transport IEA--
    GO:0006865amino acid transport TAS--
    GO:0006867asparagine transport IDA10823827
    GO:0006868glutamine transport IDA10823827

    SLC38A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC38A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC38A3 (S38A3)

    5 HMDB Compounds for SLC38A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Alanine(2S)-2-Aminopropanoate (see all 35)56-41-7--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--
    L-Glutamine(2S)-2,5-diamino-5-oxopentanoic acid (see all 31)56-85-9--
    L-Histidine(S)-1H-Imidazole-4-alanine (see all 20)71-00-1--
    SodiumSodium (see all 2)7440-23-5--

    3 DrugBank Compounds for SLC38A3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9transportersubstrate17561393 16517023 16249471
    L-Histidine(S)-4-(2-Amino-2-carboxyethyl)imidazole (see all 7)71-00-1target--15843493 17139284 17016423
    L-Asparagine(-)-Asparagine (see all 15)70-47-3target--17139284 17016423

    2 IUPHAR Ligands for SLC38A3 (SNAT3)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [14C]glutamine
    NoneNone--
    [3H]glutamine
    NoneNone--

    1 Novoseek inferred chemical compound relationship for SLC38A3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamine 54.5 4 15094455 (1), 10619430 (1), 15390112 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC38A3 / S38A3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC38A3 gene: 
    NM_006841.4  

    Unigene Cluster for SLC38A3:

    Solute carrier family 38, member 3
    Hs.76460  [show with all ESTs]
    Unigene Representative Sequence: BX537382
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427428 ENST00000420502(uc003cyn.4) ENST00000414604 ENST00000456338
    ENST00000445096 ENST00000445325 ENST00000439524 ENST00000417851 ENST00000417121
    ENST00000541861
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    Additional mRNA sequence: 

    AF244548.1 AK293801.1 AK299677.1 AK313461.1 BC042875.1 BX537382.1 CR456970.1 U49082.1 

    6 DOTS entries:

    DT.120874048  DT.112084  DT.40116304  DT.100024135  DT.100748939  DT.97842732 

    24/74 AceView cDNA sequences (see all 74):

    BQ636672 BG056098 BM663332 BC042875 BQ637389 BX537382 T62102 CF455549 
    BQ638035 BE857626 BQ636956 AI861771 BM703024 BM715712 CK903543 BI962857 
    BM662099 BM727774 AA059362 AF244548 NM_006841 BM681418 BM691699 AL713320 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A3 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:              -     -                                                                                                         
    SP2:                                                                                                                              
    SP3:              -     -     -                                                                                                   
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for SLC38A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC38A3 expression in normal human tissues (normalized intensities)      SLC38A3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTCTCTGT
    SLC38A3 Expression
    About this image


    SLC38A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
             visceral organ/gut/foregut-midgut junction   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Granulosa Cells Primary Follicle
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Choroid Plexus Cells Choroid Plexus
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Heart (Cardiovascular System)
             heart/pericardium   

    See SLC38A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC38A3

    SOURCE GeneReport for Unigene cluster: Hs.76460
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLC38A3 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc38a31 , 5 solute carrier family 38, member 31, 5 87.21(n)1
    90.26(a)1
      9 (58.69 cM)5
    762571  NM_023805.31  NP_076294.21 
     1076511555 
    chicken
    (Gallus gallus)
    Aves SLC38A31 solute carrier family 38, member 3 77.91(n)
    78.44(a)
      429200  XM_426756.3  XP_426756.3 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc48a102 wufc48a10 76.3(n)   324919  AL926364.1 


    ENSEMBL Gene Tree for SLC38A3 (if available)
    TreeFam Gene Tree for SLC38A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC38A3 gene
    5 SIMAP similar genes for SLC38A3 using alignment to 1 protein entry:     S38A3_HUMAN:
    SLC38A5    SLC38A2    SLC38A6    SLC38A1    SLC38A4

    SLC38A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/310 SNPs in SLC38A3 are shown (see all 310)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815937271,2
    --50173167(+) CTCCAC/TCCCAA 1 -- us2k10--------
    rs1177640241,2
    F--50173178(+) GGGGCC/TGCCTG 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs729329101,2
    C,F--50173286(+) CACCAA/CAGGCT 1 -- us2k12Minor allele frequency- C:0.33WA CSA 3
    rs1863153391,2
    --50173305(+) AGATTC/TGGCAG 1 -- us2k10--------
    rs1496977671,2
    C--50173374(+) ACAAA-/CAGT  
            
    CAGCC
    1 -- us2k10--------
    rs1392079561,2
    C--50173525(+) GGTGAA/CCTTGA 1 -- us2k10--------
    rs1153521331,2
    C,F--50173585(+) CAGATA/GGCTCC 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1144088681,2
    C--50173803(+) AAGGCA/GGAAGT 1 -- us2k10--------
    rs1808660561,2
    --50173806(+) GCAGAA/CGTTCG 1 -- us2k10--------
    rs20061991,2
    C,F,A,H--50173974(-) CCTGGC/TGTACC 1 -- us2k115Minor allele frequency- T:0.25NA EA MN NS 1691

    HapMap Linkage Disequilibrium report for SLC38A3 (50242679 - 50258411 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for SLC38A3 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv876771CNV Loss21882294
    nsv523662CNV Loss19592680
    nsv876770CNV Loss21882294
    dgv5131n71CNV Loss21882294
    nsv834692CNV Loss17160897
    nsv876769CNV Loss21882294
    dgv602n27CNV Loss19166990
    nsv515986CNV Loss19592680
    nsv470561CNV Loss18288195
    nsv834690CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604437    OMIM disorders: --

    4 diseases for SLC38A3:    About MalaCards
    severe combined immunodeficiency    malignant glioma    fibrosarcoma    lung cancer


    SLC38A3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC38A3

    Export disorders for SLC38A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC38A3 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with SLC38A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter. (PubMed id 10823827)1, 2, 3 Fei Y.J....Ganapathy V. (2000)
    2. Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. (PubMed id 10619430)1, 3, 9 Chaudhry F.A....Edwards R.H. (1999)
    3. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PubMed id 11085536)1, 2 Lerman M.I. and Minna J.D. (2000)
    6. Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice. (PubMed id 16432833)1, 9 Kholodnyuk I.D....Imreh S. (2006)
    7. Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas. (PubMed id 15094455)1, 9 Sidoryk M....Albrecht J. (2004)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. Manganese-induced downregulation of astroglial glutam ine transporter SNAT3 involves ubiquitin-mediated proteolytic system. (PubMed id 20737472)1 Sidoryk-Wegrzynowicz M....Aschner M. (2010)
    10. Expression and role of SNAT3 in the placenta. (PubMed id 19892400)1 Yoshioka C....Iseki K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10991 HGNC: 18044 AceView: SLC38A3 Ensembl:ENSG00000188338 euGenes: HUgn10991
    ECgene: SLC38A3 Kegg: 10991 H-InvDB: SLC38A3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC38A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC38A3 gene:
    Search GeneIP for patents involving SLC38A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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