Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC38A3 Gene

protein-coding   GIFtS: 54
GCID: GC03P050244

solute carrier family 38, member 3
 Explore 6 diseases affiliated with
SLC38A3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC38A3    

Aliases
for SLC38A3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 38, Member 31 2     Na(+)-Coupled Neutral Amino Acid Transporter 32 3
G171 2 3 5     Sodium-Coupled Neutral Amino Acid Transporter 32
SN11 2 3 5     System N1 Na+ And H+-Coupled Glutamine Transporter2
System N Amino Acid Transporter 12 3     SNAT33
NAT12 3     Solute Carrier Family 38 Member 33
N-System Amino Acid Transporter 12 3     

External Ids:    HGNC: 180441   Entrez Gene: 109912   Ensembl: ENSG000001883387   OMIM: 6044375   UniProtKB: Q996243   

Export aliases for SLC38A3 gene to outside databases

Previous GC identifers: GC03M049728 GC03M049898 GC03P050097 GC03P050201 GC03P050217


Summaries
for SLC38A3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: S38A3_HUMAN, Q99624
Function: Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions
in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either
direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission

Gene Wiki entry for SLC38A3


Genomic Views
for SLC38A3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC38A3 gene promoter:
         Egr-3   Pbx1a   p53   NF-AT   C/EBPalpha   GATA-2   c-Ets-1   HOXA5   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC38A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC38A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC38A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

SLC38A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC38A3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050244:  view genomic region     (about GC identifiers)

Start:
 50,242,679 bp from pter      End:
 50,258,411 bp from pter
Size:
 15,733 bases      Orientation:
 plus strand

Proteins
for SLC38A3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S38A3_HUMAN, Q99624 (See protein sequence)
Recommended Name: Sodium-coupled neutral amino acid transporter 3  
Size: 504 amino acids; 55773 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: B2R8Q0 Q6IB34

Explore the universe of human proteins at neXtProt for SLC38A3: NX_Q99624

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99624

    • SLC38A3 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_006832.1  Reactome Protein details: Q99624
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SLC38A3
    OriGene Custom Protein Services for SLC38A3 
    GenScript Custom Purified and Recombinant Proteins Services for SLC38A3
    Novus Biologicals SLC38A3 Protein
    Novus Biologicals SLC38A3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC38A3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane ISS--


    SLC38A3 for ontologies           About GeneDecksing



    SLC38A3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC38A3 
    GenScript Custom Superior Antibodies Services for SLC38A3
    Novus Biologicals SLC38A3 Antibodies
    Search for Antibodies for SLC38A3 at Abcam  
    Uscn Antibodies for SLC38A3
    Search ThermoFisher Antibodies for SLC38A3

    Assay Products for SLC38A3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC38A3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SLC38A3

    Protein Domains /
    Families
    for SLC38A3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC38A3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR013057 AA_transpt_TM

    Graphical View of Domain Structure for InterPro Entry Q99624

    ProtoNet protein and cluster: Q99624

    UniProtKB/Swiss-Prot: S38A3_HUMAN, Q99624
    Similarity: Belongs to the amino acid/polyamine transporter 2 family


    Function
    for SLC38A3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S38A3_HUMAN, Q99624
    Function: Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions
    in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either
    direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SLC38A3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC38A3
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC38A3 (see all 12):
    hsa-miR-3163 hsa-miR-3673 hsa-miR-206 hsa-miR-922 hsa-miR-1 hsa-miR-1285 hsa-miR-340 hsa-miR-612
    SwitchGear 3'UTR luciferase reporter plasmid: SLC38A3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC38A3 (see all 7)
    OriGene shRNA RFP: SLC38A3
    OriGene siRNA: SLC38A3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC38A3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SLC38A3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC38A3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC38A3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SLC38A3 (NM_006841)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC38A3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC38A3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SLC38A3
    Search LifeMap BioReagents cell lines for SLC38A3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A3

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005290L-histidine transmembrane transporter activity IDA10823827
    GO:0015180L-alanine transmembrane transporter activity IDA10823827
    GO:0015182L-asparagine transmembrane transporter activity IDA10823827
    GO:0015186L-glutamine transmembrane transporter activity IDA10823827
    GO:0015293symporter activity IEA--


    SLC38A3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SLC38A3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amino acid and oligopeptide SLC transporters
    		Amino acid and oligopeptide SLC transporters1.00
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    		Amino acid transport across the plasma membrane0.63
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    3Proximal tubule bicarbonate reclamation
    		Proximal tubule bicarbonate reclamation1.00
    4Opioid Signalling
    		Glutamatergic synapse0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for SLC38A3
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Amino acid and oligopeptide SLC transporters
    Amino acid transport across the plasma membrane
    Transport of inorganic cations/anions and amino acids/oligopeptides


    2         Kegg Pathways  (Kegg details for SLC38A3):
        Glutamatergic synapse
    Proximal tubule bicarbonate reclamation


    SLC38A3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC38A3

    2 Interacting proteins for SLC38A3 (Q996242, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SETDB1Q150472, 3MINT-65284 I2D: score=5 
    NEDD4P469343I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006814sodium ion transport IEA--
    GO:0006865amino acid transport TAS--
    GO:0006867asparagine transport IDA10823827
    GO:0006868glutamine transport IDA10823827


    SLC38A3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC38A3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC38A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC38A3

    5 HMDB Compounds for SLC38A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Alanine(2S)-2-Aminopropanoate (see all 35)56-41-7--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--
    L-Glutamine(2S)-2,5-diamino-5-oxopentanoic acid (see all 31)56-85-9--
    L-Histidine(S)-1H-Imidazole-4-alanine (see all 20)71-00-1--
    SodiumSodium (see all 2)7440-23-5--

    3 DrugBank Compounds for SLC38A3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9transportersubstrate17561393 16517023 16249471
    L-Histidine(S)-4-(2-Amino-2-carboxyethyl)imidazole (see all 7)71-00-1target--15843493 17139284 17016423
    L-Asparagine(-)-Asparagine (see all 15)70-47-3target--17139284 17016423

    1 Novoseek chemical compound relationship for SLC38A3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamine 54.5 4 15094455 (1), 10619430 (1), 15390112 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC38A3 / S38A3 

    Transcripts
    for SLC38A3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC38A3 gene: 
    NM_006841.4  

    Unigene Cluster for SLC38A3:

    Solute carrier family 38, member 3
    Hs.76460  [show with all ESTs]
    Unigene Representative Sequence: BX537382
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427428(lincRNA) ENST00000420502(lincRNA)(uc003cyn.4) ENST00000414604(lincRNA) ENST00000456338(lincRNA)
    ENST00000445096(lincRNA) ENST00000445325(lincRNA) ENST00000439524(lincRNA) ENST00000417851(lincRNA) ENST00000417121(lincRNA)
    ENST00000541861(lincRNA) ENST00000545531(lincRNA)(uc011bdl.2 uc011bdm.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SLC38A3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC38A3
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC38A3 (see all 12):
    hsa-miR-3163 hsa-miR-3673 hsa-miR-206 hsa-miR-922 hsa-miR-1 hsa-miR-1285 hsa-miR-340 hsa-miR-612
    SwitchGear 3'UTR luciferase reporter plasmid: SLC38A3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC38A3 (see all 7)
    OriGene shRNA RFP: SLC38A3
    OriGene siRNA: SLC38A3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC38A3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC38A3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC38A3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SLC38A3 (NM_006841)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC38A3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC38A3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC38A3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC38A3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC38A3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC38A3

    Additional cDNA sequence: 

    AF244548.1 AK293801.1 AK299677.1 AK313461.1 BC042875.1 BX537382.1 CR456970.1 U49082.1 

    6 DOTS entries:

    DT.120874048  DT.112084  DT.40116304  DT.100024135  DT.100748939  DT.97842732 

    24/74 AceView cDNA sequences (see all 74):

    BQ637389 BQ638035 NM_006841 AF244548 BX537382 BG056098 BM681418 AA059362 
    BM663332 BQ636672 BM662099 BQ636956 CK903543 CF455549 AI861771 BC042875 
    T62102 BM715712 BI962857 BE857626 BM703024 BM727774 BQ653839 BM676266 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A3 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:              -     -                                                                                                         
    SP2:                                                                                                                              
    SP3:              -     -     -                                                                                                   
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for SLC38A3

    Expression
    for SLC38A3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC38A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCTCTCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC38A3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    OvaryAntral FollicleCumulus CellsOvary
    OvaryPrimary FollicleGranulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    Genevestigator expression for SLC38A3

    SOURCE GeneReport for Unigene cluster: Hs.76460
        SABiosciences Custom PCR Arrays for SLC38A3
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC38A3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC38A3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC38A3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC38A3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A3

    Orthologs
    for SLC38A3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SLC38A3 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Slc38a31 , 5 solute carrier family 38, member 31, 5 87.21(n)1
    90.26(a)1    		   9 (58.69 cM)5
    762571  NM_023805.31  NP_076294.21 
     1076511555 
    chicken
    (Gallus gallus)    		 Aves SLC38A31 solute carrier family 38, member 3 77.91(n)
    78.44(a)    		   429200  XM_426756.3  XP_426756.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc48a102 wufc48a10 76.3(n)   324919  AL926364.1 


    ENSEMBL Gene Tree for SLC38A3 (if available)
    TreeFam Gene Tree for SLC38A3 (if available) 

    Paralogs
    for SLC38A3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SLC38A3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    3 NCBI SNPs in SLC38A3 are shown     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs112930081,2
    		C--50245695(+) TTTTT-/TGAGAT 1 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs1396506761,2
    		C,--50251833(+) CTACA-/GGGTCG 1 -- spa10--------
    rs343708461,2
    		C,F,--50298488(+) TTCATC/-CCACC 1 -- int14Minor allele frequency- -:0.50NA CSA 8

    HapMap Linkage Disequilibrium report for SLC38A3 (50242679 - 50258411 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for SLC38A3
         8 CNVs: 30176 4335 3429 53228 51108 30175 51107 51112

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC38A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC38A3

    Disorders / Diseases
    for SLC38A3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC38A3 for disorders           About GeneDecksing

    OMIM gene information: 604437    OMIM disorders: --

    6 diseases for SLC38A3:    About MalaCards
    severe combined immunodeficiency    combined immunodeficiency    malignant glioma    fibrosarcoma
    immunodeficiency    lung cancer


    Export disorders for SLC38A3 gene to outside databases

    Publications
    for SLC38A3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC38A3 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with SLC38A3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter. (PubMed id 10823827)1, 2, 3 Fei Y.J....Ganapathy V. (2000)
    2. Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. (PubMed id 10619430)1, 3, 9 Chaudhry F.A....Edwards R.H. (1999)
    3. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PubMed id 11085536)1, 2 Lerman M.I. and Minna J.D. (2000)
    6. Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice. (PubMed id 16432833)1, 9 Kholodnyuk I.D....Imreh S. (2006)
    7. Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas. (PubMed id 15094455)1, 9 Sidoryk M....Albrecht J. (2004)
    8. Manganese-induced downregulation of astroglial glutam ine transporter SNAT3 involves ubiquitin-mediated proteolytic system. (PubMed id 20737472)1 Sidoryk-Wegrzynowicz M....Aschner M. (2010)
    9. Expression and role of SNAT3 in the placenta. (PubMed id 19892400)1 Yoshioka C....Iseki K. (2009)
    10. Amino acid transport across mammalian intestinal and renal epithelia. (PubMed id 18195088)1 BrAPer S. (2008)

    External Searches for SLC38A3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC38A3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10991 HGNC: 18044 AceView: SLC38A3 Ensembl:ENSG00000188338 euGenes: HUgn10991
    ECgene: SLC38A3 Kegg: 10991 H-InvDB: SLC38A3

    Other Databases showing SLC38A3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC38A3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC38A3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC38A3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC38A3 gene:
    Search GeneIP for patents involving SLC38A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SLC38A3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SLC38A3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC38A3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC38A3  
     OriGene Protein Over-expression Lysate for SLC38A3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SLC38A3   OriGene 3'-UTR Clone for SLC38A3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC38A3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC38A3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC38A3   OriGene Custom Protein Services for SLC38A3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC38A3
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC38A3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC38A3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC38A3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC38A3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC38A3
     GenScript Custom Purified and Recombinant Proteins Services for SLC38A3 GenScript cDNA clones with any tag delivered in your preferred vector for SLC38A3
     GenScript Custom Assay Services for SLC38A3 GenScript Custom Superior Antibodies Services for SLC38A3
     GenScript Custom overexpressing Cell Line Services for SLC38A3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC38A3 promoter
     Search Chromatin IP Primers for SLC38A3
     RT2 qPCR Primer Assay in human, mouse, rat SLC38A3
     Search GNC Networks for SLC38A3
     SABiosciences Custom PCR Arrays for SLC38A3
     Search Tocris compounds for SLC38A3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC38A3 antibodies
     SLC38A3 proteins
     SLC38A3 lysates
     Search for Antibodies for SLC38A3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SLC38A3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SLC38A3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SLC38A3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A3
     SwitchGear 3'UTR luciferase reporter plasmids for SLC38A3
     SwitchGear Promoter luciferase reporter plasmids for SLC38A3
     Search ThermoFisher Antibodies for SLC38A3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC38A3
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SLC38A3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4