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SLC38A3 Gene

protein-coding   GIFtS: 55
GCID: GC03P050244

Solute Carrier Family 38, Member 3

  Search for SLC38A3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Solute Carrier Family 38, Member 31 2     Na(+)-Coupled Neutral Amino Acid Transporter 32 3
G172 3 5     Sodium-Coupled Neutral Amino Acid Transporter 32
SN12 3 5     System N1 Na+ And H+-Coupled Glutamine Transporter2
System N Amino Acid Transporter 12 3     SNAT33
NAT12 3     Solute Carrier Family 38 Member 33
N-System Amino Acid Transporter 12 3     

External Ids:    HGNC: 180441   Entrez Gene: 109912   Ensembl: ENSG000001883387   OMIM: 6044375   UniProtKB: Q996243   
ORGUL members:         

Export aliases for SLC38A3 gene to outside databases

Previous GC identifers: GC03M049728 GC03M049898 GC03P050097 GC03P050201 GC03P050217


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC38A3 Gene:
SLC38A3 (solute carrier family 38, member 3) is a protein-coding gene. GO annotations related to this gene include L-alanine transmembrane transporter activity and symporter activity.

UniProtKB/Swiss-Prot: S38A3_HUMAN, Q99624
Function: Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium
ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport
in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic
transmission

Gene Wiki entry for SLC38A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC38A3 gene promoter:
         Egr-3   Pbx1a   p53   NF-AT   C/EBPalpha   GATA-2   c-Ets-1   HOXA5   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC38A3 promoter sequence
   Search Chromatin IP Primers for SLC38A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC38A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

SLC38A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC38A3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050244:  view genomic region     (about GC identifiers)

Start:
50,242,679 bp from pter      End:
50,258,411 bp from pter
Size:
15,733 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S38A3_HUMAN, Q99624 (See protein sequence)
Recommended Name: Sodium-coupled neutral amino acid transporter 3  
Size: 504 amino acids; 55773 Da
Secondary accessions: B2R8Q0 Q6IB34

Explore the universe of human proteins at neXtProt for SLC38A3: NX_Q99624

Explore proteomics data for SLC38A3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn74, Asn247, Asn248, Asn252, Asn323
  • Modification sites at PhosphoSitePlus

  • See SLC38A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006832.1  Reactome Protein details: Q99624

    SLC38A3 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for SLC38A3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SNAT3
    System N-like transporters

    1 InterPro protein domain:
     IPR013057 AA_transpt_TM

    Graphical View of Domain Structure for InterPro Entry Q99624

    ProtoNet protein and cluster: Q99624

    UniProtKB/Swiss-Prot: S38A3_HUMAN, Q99624
    Similarity: Belongs to the amino acid/polyamine transporter 2 family


    Find genes that share domains with SLC38A3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S38A3_HUMAN, Q99624
    Function: Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium
    ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport
    in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic
    transmission

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005290L-histidine transmembrane transporter activity IDA10823827
    GO:0015180L-alanine transmembrane transporter activity IDA10823827
    GO:0015182L-asparagine transmembrane transporter activity IDA10823827
    GO:0015186L-glutamine transmembrane transporter activity IDA10823827
    GO:0015293symporter activity IEA--
         
    Find genes that share ontologies with SLC38A3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC38A3
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    miRNA
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    hsa-mir-25-3p (MIRT050208), hsa-mir-26b-5p (MIRT030309)

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    Selected qRT-PCR Assays for microRNAs that regulate SLC38A3 (see all 12):
    hsa-miR-3163 hsa-miR-3673 hsa-miR-206 hsa-miR-922 hsa-miR-1 hsa-miR-1285 hsa-miR-340 hsa-miR-612
    SwitchGear 3'UTR luciferase reporter plasmidSLC38A3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S38A3_HUMAN, Q99624: Cell membrane; Multi-pass membrane protein (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane ISS--

    Find genes that share ontologies with SLC38A3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC38A3 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Amino acid transport across the plasma membrane0.32
    2Circadian entrainment
    GABAergic synapse0.53
    Glutamatergic synapse0.39
    3Proximal tubule bicarbonate reclamation
    Proximal tubule bicarbonate reclamation


    Find genes that share SuperPaths with SLC38A3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC38A3
        Amino acid transport across the plasma membrane


    3 Kegg Pathways  (Kegg details for SLC38A3):
        Glutamatergic synapse
    GABAergic synapse
    Proximal tubule bicarbonate reclamation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC38A3
    Interactions:

        Search GeneGlobe Interaction Network for SLC38A3

    2 Interacting proteins for SLC38A3 (Q996242, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SETDB1Q150472, 3MINT-65284 I2D: score=5 
    NEDD4P469343I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006814sodium ion transport IEA--
    GO:0006865amino acid transport TAS--
    GO:0006867asparagine transport IDA10823827
    GO:0006868glutamine transport IDA10823827

    Find genes that share ontologies with SLC38A3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC38A3 (S38A3)

    5 HMDB Compounds for SLC38A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Alanine(2S)-2-Aminopropanoate (see all 35)56-41-7--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--
    L-Glutamine(2S)-2,5-diamino-5-oxopentanoic acid (see all 31)56-85-9--
    L-Histidine(S)-1H-Imidazole-4-alanine (see all 20)71-00-1--
    SodiumSodium (see all 2)7440-23-5--

    3 DrugBank Compounds for SLC38A3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9transportersubstrate17561393 16517023 16249471
    L-Histidine(S)-4-(2-Amino-2-carboxyethyl)imidazole (see all 7)71-00-1target--15843493 17139284 17016423
    L-Asparagine(-)-Asparagine (see all 15)70-47-3target--17139284 17016423

    2 IUPHAR Ligands for SLC38A3 (SNAT3)    About this table
    LigandTypeActionAffinityPubmed IDs
    [14C]glutamine
    NoneNone--
    [3H]glutamine
    NoneNone--

    1 Novoseek inferred chemical compound relationship for SLC38A3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamine 54.5 4 15094455 (1), 10619430 (1), 15390112 (1)



    Find genes that share compounds with SLC38A3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC38A3 gene: 
    NM_006841.5  

    Unigene Cluster for SLC38A3:

    Solute carrier family 38, member 3
    Hs.76460  [show with all ESTs]
    Unigene Representative Sequence: BX537382
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427428(processed_transcript) ENST00000420502(processed_transcript) ENST00000414604(processed_transcript) ENST00000456338(processed_transcript) ENST00000445096(processed_transcript)
    ENST00000445325(processed_transcript) ENST00000439524(processed_transcript) ENST00000417851(processed_transcript) ENST00000417121(processed_transcript) ENST00000541861(processed_transcript)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC38A3 (see all 12):
    hsa-miR-3163 hsa-miR-3673 hsa-miR-206 hsa-miR-922 hsa-miR-1 hsa-miR-1285 hsa-miR-340 hsa-miR-612
    SwitchGear 3'UTR luciferase reporter plasmidSLC38A3 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC38A3
      QuantiFast Probe-based Assays in human, mouse, rat SLC38A3

    Additional mRNA sequence: 

    AF244548.1 AK293801.1 AK299677.1 AK313461.1 BC042875.1 BX537382.1 CR456970.1 U49082.1 

    6 DOTS entries:

    DT.120874048  DT.112084  DT.40116304  DT.100024135  DT.100748939  DT.97842732 

    Selected AceView cDNA sequences (see all 74):

    AA059362 BQ638035 CK903543 AF244548 BX537382 BM681418 BQ636672 T62102 
    BM663332 BM662099 BQ636956 BG056098 BM727774 AI861771 CF455549 BM703024 
    BI962857 BQ637389 NM_006841 BE857626 BM715712 BC042875 CR456970 AU279913 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A3 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:              -     -                                                                                                         
    SP2:                                                                                                                              
    SP3:              -     -     -                                                                                                   
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for SLC38A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC38A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTCTCTGT
    SLC38A3 Expression
    About this image


    SLC38A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Granulosa Cells Primary Follicle
     
     Liver (Hepatobiliary System)
    SLC38A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC38A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.76460
        Custom PCR Arrays for SLC38A3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC38A3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc38a31 , 5 solute carrier family 38, member 31, 5 87.21(n)1
    90.26(a)1
      9 (58.69 cM)5
    762571  NM_023805.31  NP_076294.21 
     1076511555 
    chicken
    (Gallus gallus)
    Aves SLC38A31 solute carrier family 38, member 3 78.33(n)
    79.4(a)
      429200  XM_426756.4  XP_426756.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc38a31 solute carrier family 38, member 3 72.45(n)
    77.02(a)
      594944  NM_001030377.1  NP_001025548.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc48a102 wufc48a10 76.3(n)   324919  AL926364.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G388201 AT5G38820 41.05(n)
    32.32(a)
      833873  NM_123243.1  NP_198698.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02758001 Os06g0275800 44.68(n)
    32.71(a)
      4340751  NM_001063917.1  NP_001057382.1 


    ENSEMBL Gene Tree for SLC38A3 (if available)
    TreeFam Gene Tree for SLC38A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC38A3 gene
    5 SIMAP similar genes for SLC38A3 using alignment to 1 protein entry:     S38A3_HUMAN:
    SLC38A5    SLC38A2    SLC38A6    SLC38A1    SLC38A4

    Find genes that share paralogs with SLC38A3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC38A3 (see all 310)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815937271,2
    --50173167(+) CTCCAC/TCCCAA 1 -- us2k10--------
    rs1177640241,2
    F--50173178(+) GGGGCC/TGCCTG 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs729329101,2
    C,F--50173286(+) CACCAA/CAGGCT 1 -- us2k12Minor allele frequency- C:0.33WA CSA 3
    rs1863153391,2
    --50173305(+) AGATTC/TGGCAG 1 -- us2k10--------
    rs1496977671,2
    C--50173374(+) ACAAA-/CAGT  
            
    CAGCC
    1 -- us2k10--------
    rs1392079561,2
    C--50173525(+) GGTGAA/CCTTGA 1 -- us2k10--------
    rs1153521331,2
    C,F--50173585(+) CAGATA/GGCTCC 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1144088681,2
    C--50173803(+) AAGGCA/GGAAGT 1 -- us2k10--------
    rs1808660561,2
    --50173806(+) GCAGAA/CGTTCG 1 -- us2k10--------
    rs20061991,2
    C,F,A,H--50173974(-) CCTGGC/TGTACC 1 -- us2k115Minor allele frequency- T:0.25NA EA MN NS 1691

    HapMap Linkage Disequilibrium report for SLC38A3 (50242679 - 50258411 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC38A3 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876771CNV Loss21882294
    nsv523662CNV Loss19592680
    nsv876770CNV Loss21882294
    dgv5131n71CNV Loss21882294
    nsv834692CNV Loss17160897
    nsv876769CNV Loss21882294
    dgv602n27CNV Loss19166990
    nsv515986CNV Loss19592680
    nsv470561CNV Loss18288195
    nsv834690CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SLC38A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC38A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604437    OMIM disorders: --


    Find genes that share disorders with SLC38A3           About GenesLikeMe

    Genetic Association Database (GAD): SLC38A3

    Export disorders for SLC38A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC38A3 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with SLC38A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+- coupled glutamine transporter. (PubMed id 10823827)1, 2, 3 Fei Y.-J.... Ganapathy V. (J. Biol. Chem. 2000)
    2. Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. (PubMed id 10619430)1, 3, 9 Chaudhry F.A....Edwards R.H. (Cell 1999)
    3. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PubMed id 11085536)1, 2 Lerman M.I. and Minna J.D. (Cancer Res. 2000)
    6. Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice. (PubMed id 16432833)1, 9 Kholodnyuk I.D....Imreh S. (Int. J. Cancer 2006)
    7. Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas. (PubMed id 15094455)1, 9 Sidoryk M....Albrecht J. (Neuroreport 2004)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Manganese-induced downregulation of astroglial glutamine transporter SNAT3 involves ubiquitin-mediated proteolytic system. (PubMed id 20737472)1 Sidoryk-Wegrzynowicz M....Aschner M. (Glia 2010)
    10. Expression and role of SNAT3 in the placenta. (PubMed id 19892400)1 Yoshioka C....Iseki K. (Placenta 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10991 HGNC: 18044 AceView: SLC38A3 Ensembl:ENSG00000188338 euGenes: HUgn10991
    ECgene: SLC38A3 Kegg: 10991 H-InvDB: SLC38A3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC38A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC38A3 gene:
    Search GeneIP for patents involving SLC38A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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