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Aliases for SLC38A2 Gene

Aliases for SLC38A2 Gene

  • Solute Carrier Family 38 Member 2 2 3 4 5
  • Solute Carrier Family 38, Member 2 2 3
  • System A Amino Acid Transporter 2 3 4
  • System N Amino Acid Transporter 2 3 4
  • Amino Acid Transporter A2 3 4
  • System A Transporter 1 3 4
  • Protein 40-9-1 3 4
  • SNAT2 3 4
  • ATA2 3 4
  • SAT2 3 4
  • Amino Acid Transporter 2 3
  • KIAA1382 4
  • PRO1068 3

External Ids for SLC38A2 Gene

Previous GeneCards Identifiers for SLC38A2 Gene

  • GC12M046829
  • GC12M046649
  • GC12M046468
  • GC12M045038
  • GC12M043783
  • GC12M046751

Summaries for SLC38A2 Gene

GeneCards Summary for SLC38A2 Gene

SLC38A2 (Solute Carrier Family 38 Member 2) is a Protein Coding gene. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include symporter activity and amino acid transmembrane transporter activity. An important paralog of this gene is SLC38A1.

UniProtKB/Swiss-Prot for SLC38A2 Gene

  • Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.

Gene Wiki entry for SLC38A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A2 Gene

Genomics for SLC38A2 Gene

Regulatory Elements for SLC38A2 Gene

Promoters for SLC38A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC38A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC38A2 Gene

Chromosome:
12
Start:
46,358,188 bp from pter
End:
46,372,867 bp from pter
Size:
14,680 bases
Orientation:
Minus strand

Genomic View for SLC38A2 Gene

Genes around SLC38A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC38A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC38A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A2 Gene

Proteins for SLC38A2 Gene

  • Protein details for SLC38A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QD8-S38A2_HUMAN
    Recommended name:
    Sodium-coupled neutral amino acid transporter 2
    Protein Accession:
    Q96QD8
    Secondary Accessions:
    • Q6IA88
    • Q6ZMG2
    • Q9HAV3
    • Q9NVA8
    • Q9P2G5

    Protein attributes for SLC38A2 Gene

    Size:
    506 amino acids
    Molecular mass:
    56026 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress.
    SequenceCaution:
    • Sequence=BAD18765.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC38A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC38A2 Gene

Proteomics data for SLC38A2 Gene at MOPED

Post-translational modifications for SLC38A2 Gene

  • Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.
  • Ubiquitination at Lys 33 and Lys 38
  • Glycosylation at Asn 258 and Asn 274
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC38A2 Gene

Antibody Products

No data available for DME Specific Peptides for SLC38A2 Gene

Domains & Families for SLC38A2 Gene

Gene Families for SLC38A2 Gene

Protein Domains for SLC38A2 Gene

Suggested Antigen Peptide Sequences for SLC38A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QD8

UniProtKB/Swiss-Prot:

S38A2_HUMAN :
  • Belongs to the amino acid/polyamine transporter 2 family.
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A2: view

Function for SLC38A2 Gene

Molecular function for SLC38A2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.39 mM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.0);
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-methyl-D-glucamine and probably choline.
UniProtKB/Swiss-Prot Function:
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon hypertonic conditions and amino acid deprivation.
genes like me logo Genes that share phenotypes with SLC38A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC38A2

CRISPR Products

miRNA for SLC38A2 Gene

miRTarBase miRNAs that target SLC38A2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC38A2 Gene

Localization for SLC38A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A2 Gene

Cell membrane; Multi-pass membrane protein. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC38A2 Gene COMPARTMENTS Subcellular localization image for SLC38A2 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC38A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with SLC38A2: view

Pathways & Interactions for SLC38A2 Gene

genes like me logo Genes that share pathways with SLC38A2: view

Gene Ontology (GO) - Biological Process for SLC38A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0007565 female pregnancy IEA --
GO:0034198 cellular response to amino acid starvation IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC38A2: view

No data available for SIGNOR curated interactions for SLC38A2 Gene

Drugs & Compounds for SLC38A2 Gene

(3) Drugs for SLC38A2 Gene - From: Novoseek, IUPHAR, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>14</sup>C]alanine Pharma 0
[<sup>3</sup>H]alanine Pharma 0

(4) Additional Compounds for SLC38A2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC38A2: view

Transcripts for SLC38A2 Gene

Unigene Clusters for SLC38A2 Gene

Solute carrier family 38, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5:
SP6: -
SP7:

Relevant External Links for SLC38A2 Gene

GeneLoc Exon Structure for
SLC38A2
ECgene alternative splicing isoforms for
SLC38A2

Expression for SLC38A2 Gene

mRNA expression in normal human tissues for SLC38A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC38A2 Gene

This gene is overexpressed in Amniocyte (33.4) and Liver (21.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC38A2 Gene



SOURCE GeneReport for Unigene cluster for SLC38A2 Gene Hs.221847

mRNA Expression by UniProt/SwissProt for SLC38A2 Gene

Q96QD8-S38A2_HUMAN
Tissue specificity: Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).
genes like me logo Genes that share expression patterns with SLC38A2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SLC38A2 Gene

Orthologs for SLC38A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC38A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC38A2 35
  • 99.87 (n)
  • 99.8 (a)
SLC38A2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC38A2 36
  • 90 (a)
OneToOne
SLC38A2 35
  • 91.3 (n)
  • 89.72 (a)
dog
(Canis familiaris)
Mammalia SLC38A2 35
  • 91.55 (n)
  • 92.67 (a)
SLC38A2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc38a2 16
Slc38a2 36
  • 89 (a)
OneToOne
Slc38a2 35
  • 82.84 (n)
  • 89.26 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC38A2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc38a2 35
  • 83.4 (n)
  • 88.29 (a)
chicken
(Gallus gallus)
Aves SLC38A2 35
  • 78.13 (n)
  • 80.28 (a)
SLC38A2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC38A2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc38a2 35
  • 71.84 (n)
  • 75.53 (a)
zebrafish
(Danio rerio)
Actinopterygii slc38a2 36
  • 70 (a)
OneToOne
slc38a2 35
  • 67 (n)
  • 71.81 (a)
Species with no ortholog for SLC38A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC38A2 Gene

ENSEMBL:
Gene Tree for SLC38A2 (if available)
TreeFam:
Gene Tree for SLC38A2 (if available)

Paralogs for SLC38A2 Gene

Paralogs for SLC38A2 Gene

(5) SIMAP similar genes for SLC38A2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SLC38A2 Gene

genes like me logo Genes that share paralogs with SLC38A2: view

Variants for SLC38A2 Gene

Sequence variations from dbSNP and Humsavar for SLC38A2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_037235 -
rs2307060 -- 46,364,846(-) GTATC(A/G)TAAGA intron-variant
rs2897968 -- 46,369,903(+) CTAAA(A/G)TATTC intron-variant
rs3742061 -- 46,369,987(-) GACCC(C/T)GAAAA intron-variant
rs3782904 -- 46,364,202(-) TAATC(A/G)TATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC38A2 Gene

Variant ID Type Subtype PubMed ID
nsv832398 CNV Gain 17160897

Variation tolerance for SLC38A2 Gene

Residual Variation Intolerance Score: 33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC38A2 Gene

HapMap Linkage Disequilibrium report
SLC38A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC38A2 Gene

Disorders for SLC38A2 Gene

Relevant External Links for SLC38A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC38A2

No disorders were found for SLC38A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC38A2 Gene

Publications for SLC38A2 Gene

  1. SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress. (PMID: 15922329) Bevilacqua E. … Franchi-Gazzola R. (FEBS Lett. 2005) 3 4 23 67
  2. IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2. (PMID: 19741197) Jones H.N. … Powell T.L. (Am. J. Physiol., Cell Physiol. 2009) 3 23
  3. The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates. (PMID: 17237199) Zhang Z. … Grewer C. (Biophys. J. 2007) 2 3
  4. Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. (PMID: 14623874) Palii S.S. … Kilberg M.S. (J. Biol. Chem. 2004) 3 23
  5. Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A. (PMID: 10747860) Sugawara M. … Ganapathy V. (J. Biol. Chem. 2000) 2 3

Products for SLC38A2 Gene

Sources for SLC38A2 Gene

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