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Aliases for SLC38A2 Gene

Aliases for SLC38A2 Gene

  • Solute Carrier Family 38 Member 2 2 3 4 5
  • System A Amino Acid Transporter 2 3 4
  • System N Amino Acid Transporter 2 3 4
  • Amino Acid Transporter A2 3 4
  • System A Transporter 1 3 4
  • Protein 40-9-1 3 4
  • SNAT2 3 4
  • ATA2 3 4
  • SAT2 3 4
  • Sodium-Coupled Neutral Amino Acid Transporter 2 3
  • Solute Carrier Family 38, Member 2 2
  • Amino Acid Transporter 2 3
  • KIAA1382 4
  • PRO1068 3

External Ids for SLC38A2 Gene

Previous GeneCards Identifiers for SLC38A2 Gene

  • GC12M046829
  • GC12M046649
  • GC12M046468
  • GC12M045038
  • GC12M043783
  • GC12M046751

Summaries for SLC38A2 Gene

GeneCards Summary for SLC38A2 Gene

SLC38A2 (Solute Carrier Family 38 Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Collagen chain trimerization. GO annotations related to this gene include symporter activity and amino acid transmembrane transporter activity. An important paralog of this gene is SLC38A4.

UniProtKB/Swiss-Prot for SLC38A2 Gene

  • Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.

Gene Wiki entry for SLC38A2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A2 Gene

Genomics for SLC38A2 Gene

Regulatory Elements for SLC38A2 Gene

Enhancers for SLC38A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G046546 2 FANTOM5 Ensembl ENCODE dbSUPER 12.9 -182.5 -182475 17.7 PKNOX1 ARNT ZFP64 SIN3A FEZF1 ZNF766 FOS DEK SP3 JUNB SLC38A2 LINC00938 ENSG00000257261 ENSG00000272369 OR7A19P
GH12G046469 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12 -99.8 -99846 6.2 HDGF HNRNPUL1 FOXA2 WRNIP1 SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF302 ENSG00000257261 SLC38A2 ENSG00000272369 PIR40337
GH12G046206 2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +157.9 157930 17.4 HDGF PKNOX1 WRNIP1 SIN3A YBX1 ZNF2 YY1 ZNF766 CBX5 ZNF143 SLC38A1 SLC38A2 ARID2 ENSG00000257261 SCAF11 ENSG00000274591 GC12M046187
GH12G046489 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -119.6 -119603 6.6 FOXA2 MLX ARID4B FEZF1 DMAP1 YY1 SLC30A9 FOS SP5 KAT8 SLC38A2 ENSG00000272369 PIR40337
GH12G046521 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -151.3 -151315 4.7 FOXA2 ATF1 ARID4B SIN3A TCF12 SLC30A9 GATA2 FOS JUNB NFYC ENSG00000257261 SLC38A2 ENSG00000272369 PIR40337
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC38A2 on UCSC Golden Path with GeneCards custom track

Promoters for SLC38A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051227 867 3601 MLX AGO1 ZFP64 DMAP1 SLC30A9 ZNF143 SP3 ZNF610 GLIS1 NBN

Genomic Location for SLC38A2 Gene

Chromosome:
12
Start:
46,358,188 bp from pter
End:
46,372,867 bp from pter
Size:
14,680 bases
Orientation:
Minus strand

Genomic View for SLC38A2 Gene

Genes around SLC38A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC38A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC38A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A2 Gene

Proteins for SLC38A2 Gene

  • Protein details for SLC38A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QD8-S38A2_HUMAN
    Recommended name:
    Sodium-coupled neutral amino acid transporter 2
    Protein Accession:
    Q96QD8
    Secondary Accessions:
    • Q6IA88
    • Q6ZMG2
    • Q9HAV3
    • Q9NVA8
    • Q9P2G5

    Protein attributes for SLC38A2 Gene

    Size:
    506 amino acids
    Molecular mass:
    56026 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress.
    SequenceCaution:
    • Sequence=BAD18765.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC38A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC38A2 Gene

Post-translational modifications for SLC38A2 Gene

  • Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.
  • Ubiquitination at Lys33 and isoforms=38
  • Glycosylation at isoforms=2258 and isoforms=2274
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC38A2 Gene

No data available for DME Specific Peptides for SLC38A2 Gene

Domains & Families for SLC38A2 Gene

Gene Families for SLC38A2 Gene

Protein Domains for SLC38A2 Gene

Suggested Antigen Peptide Sequences for SLC38A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QD8

UniProtKB/Swiss-Prot:

S38A2_HUMAN :
  • Belongs to the amino acid/polyamine transporter 2 family.
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A2: view

Function for SLC38A2 Gene

Molecular function for SLC38A2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.39 mM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.0);
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-methyl-D-glucamine and probably choline.
UniProtKB/Swiss-Prot Function:
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon hypertonic conditions and amino acid deprivation.

Gene Ontology (GO) - Molecular Function for SLC38A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25759021
GO:0015171 amino acid transmembrane transporter activity TAS --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC38A2: view
genes like me logo Genes that share phenotypes with SLC38A2: view

Animal Models for SLC38A2 Gene

MGI Knock Outs for SLC38A2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC38A2

CRISPR Products

miRNA for SLC38A2 Gene

miRTarBase miRNAs that target SLC38A2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC38A2 Gene

Localization for SLC38A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A2 Gene

Cell membrane; Multi-pass membrane protein. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC38A2 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC38A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005903 brush border IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC38A2: view

Pathways & Interactions for SLC38A2 Gene

genes like me logo Genes that share pathways with SLC38A2: view

Gene Ontology (GO) - Biological Process for SLC38A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006865 amino acid transport TAS --
genes like me logo Genes that share ontologies with SLC38A2: view

No data available for SIGNOR curated interactions for SLC38A2 Gene

Drugs & Compounds for SLC38A2 Gene

(4) Drugs for SLC38A2 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>14</sup>C]alanine Pharma 0
[<sup>3</sup>H]alanine Pharma 0

(3) Additional Compounds for SLC38A2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC38A2: view

Transcripts for SLC38A2 Gene

Unigene Clusters for SLC38A2 Gene

Solute carrier family 38, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5:
SP6: -
SP7:

Relevant External Links for SLC38A2 Gene

GeneLoc Exon Structure for
SLC38A2
ECgene alternative splicing isoforms for
SLC38A2

Expression for SLC38A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC38A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC38A2 Gene

This gene is overexpressed in Amniocyte (33.4) and Liver (21.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC38A2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC38A2 Gene:

SLC38A2

SOURCE GeneReport for Unigene cluster for SLC38A2 Gene:

Hs.221847

mRNA Expression by UniProt/SwissProt for SLC38A2 Gene:

Q96QD8-S38A2_HUMAN
Tissue specificity: Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).

Evidence on tissue expression from TISSUES for SLC38A2 Gene

  • Nervous system(5)
  • Eye(4.5)
  • Muscle(4.2)
  • Liver(3.8)
  • Heart(2.5)
  • Intestine(2.5)
  • Lung(2.2)
  • Skin(2.1)
  • Stomach(2.1)
  • Gall bladder(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with SLC38A2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC38A2 Gene

Orthologs for SLC38A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC38A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC38A2 34 35
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia SLC38A2 34 35
  • 91.55 (n)
cow
(Bos Taurus)
Mammalia SLC38A2 34 35
  • 91.3 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC38A2 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 85 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc38a2 34
  • 83.4 (n)
mouse
(Mus musculus)
Mammalia Slc38a2 34 16 35
  • 82.84 (n)
chicken
(Gallus gallus)
Aves SLC38A2 34 35
  • 78.13 (n)
lizard
(Anolis carolinensis)
Reptilia SLC38A2 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc38a2 34
  • 71.84 (n)
zebrafish
(Danio rerio)
Actinopterygii slc38a2 34 35
  • 67 (n)
Species where no ortholog for SLC38A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC38A2 Gene

ENSEMBL:
Gene Tree for SLC38A2 (if available)
TreeFam:
Gene Tree for SLC38A2 (if available)

Paralogs for SLC38A2 Gene

Paralogs for SLC38A2 Gene

(5) SIMAP similar genes for SLC38A2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC38A2: view

Variants for SLC38A2 Gene

Sequence variations from dbSNP and Humsavar for SLC38A2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000065282 -- 46,373,207(+) ACACT(C/T)TCTTG intron-variant, upstream-variant-2KB
rs1000112554 -- 46,368,338(+) TGACT(A/G)TCTCT intron-variant
rs1000144932 -- 46,372,697(+) CGCGA(A/G)CGTGC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000214182 -- 46,373,784(+) CTGCT(C/G)TCTTC downstream-variant-500B, upstream-variant-2KB
rs1000519888 -- 46,372,440(+) CCTCC(C/T)GGAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC38A2 Gene

Variant ID Type Subtype PubMed ID
nsv832398 CNV gain 17160897

Variation tolerance for SLC38A2 Gene

Residual Variation Intolerance Score: 33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC38A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC38A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC38A2 Gene

Disorders for SLC38A2 Gene

Relevant External Links for SLC38A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC38A2

No disorders were found for SLC38A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC38A2 Gene

Publications for SLC38A2 Gene

  1. SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress. (PMID: 15922329) Bevilacqua E. … Franchi-Gazzola R. (FEBS Lett. 2005) 3 4 22 64
  2. Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. (PMID: 14623874) Palii S.S. … Kilberg M.S. (J. Biol. Chem. 2004) 3 4 22 64
  3. IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2. (PMID: 19741197) Jones H.N. … Powell T.L. (Am. J. Physiol., Cell Physiol. 2009) 3 22 64
  4. The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates. (PMID: 17237199) Zhang Z. … Grewer C. (Biophys. J. 2007) 2 3 64
  5. Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex. (PMID: 16616430) Melone M. … Conti F. (Neuroscience 2006) 3 4 64

Products for SLC38A2 Gene

Sources for SLC38A2 Gene

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