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Aliases for SLC38A11 Gene

Aliases for SLC38A11 Gene

  • Solute Carrier Family 38 Member 11 2 3 4 5
  • AVT2 3 4
  • Putative Sodium-Coupled Neutral Amino Acid Transporter 11 3
  • Solute Carrier Family 38, Member 11 2

External Ids for SLC38A11 Gene

Previous GeneCards Identifiers for SLC38A11 Gene

  • GC02M165464
  • GC02M165754
  • GC02M157637

Summaries for SLC38A11 Gene

GeneCards Summary for SLC38A11 Gene

SLC38A11 (Solute Carrier Family 38 Member 11) is a Protein Coding gene. GO annotations related to this gene include amino acid transmembrane transporter activity. An important paralog of this gene is SLC38A3.

UniProtKB/Swiss-Prot for SLC38A11 Gene

  • Putative sodium-dependent amino acid/proton antiporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A11 Gene

Genomics for SLC38A11 Gene

Regulatory Elements for SLC38A11 Gene

Enhancers for SLC38A11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F164908 1.5 FANTOM5 Ensembl ENCODE 19.8 +43.6 43555 7.5 ATF1 ZFP64 SIN3A ARID4B YY1 ZNF121 ZNF143 FOS NFYC KAT8 SLC38A11 RNA5SP111 COBLL1 ENSG00000236283
GH02F164895 1.2 Ensembl ENCODE 20.2 +58.1 58137 4.8 ATF1 MLX ARID4B DMAP1 SLC30A9 FOS NFYC JUNB MXD4 MIER2 SLC38A11 RNA5SP111 ENSG00000236283
GH02F164933 1.3 Ensembl ENCODE 15.6 +19.4 19403 5.2 PKNOX1 ATF1 MLX SIN3A ZNF48 YY1 SLC30A9 GLIS2 FOS ZNF263 SLC38A11 ENSG00000236283
GH02F164966 1 Ensembl ENCODE 15.6 -12.8 -12831 3.1 FEZF1 ZNF101 PRDM10 KLF8 ZNF263 YY2 GFI1B ZBTB8A ZNF501 ZNF843 SLC38A11 GC02M165092
GH02F164919 1.1 Ensembl ENCODE 11.1 +35.0 34998 1.5 ELF3 FEZF1 RAD21 YY1 FOS MIXL1 CEBPB KAT8 RCOR2 CEBPA SLC38A11 ENSG00000236283
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC38A11 on UCSC Golden Path with GeneCards custom track

Promoters for SLC38A11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001829096 259 999 CTCF SCRT2 ZEB2 NR3C1 PRDM1 RAD21 EGR2

Genomic Location for SLC38A11 Gene

164,896,186 bp from pter
164,955,560 bp from pter
59,375 bases
Minus strand

Genomic View for SLC38A11 Gene

Genes around SLC38A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC38A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC38A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A11 Gene

Proteins for SLC38A11 Gene

  • Protein details for SLC38A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative sodium-coupled neutral amino acid transporter 11
    Protein Accession:
    Secondary Accessions:
    • B4DF99
    • Q8N887

    Protein attributes for SLC38A11 Gene

    406 amino acids
    Molecular mass:
    44825 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC38A11 Gene


neXtProt entry for SLC38A11 Gene

Post-translational modifications for SLC38A11 Gene

  • Glycosylation at Asn 44 and Asn 275
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC38A11 Gene

Domains & Families for SLC38A11 Gene

Gene Families for SLC38A11 Gene


Protein Domains for SLC38A11 Gene


Suggested Antigen Peptide Sequences for SLC38A11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the amino acid/polyamine transporter 2 family.
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A11: view

Function for SLC38A11 Gene

Molecular function for SLC38A11 Gene

UniProtKB/Swiss-Prot Function:
Putative sodium-dependent amino acid/proton antiporter.

Gene Ontology (GO) - Molecular Function for SLC38A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC38A11: view
genes like me logo Genes that share phenotypes with SLC38A11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC38A11

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC38A11 Gene

Localization for SLC38A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC38A11 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC38A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC38A11: view

Pathways & Interactions for SLC38A11 Gene

SuperPathways for SLC38A11 Gene

No Data Available

Interacting Proteins for SLC38A11 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
Selected Interacting proteins: ENSP00000386272 Q08AI6-S38AB_HUMAN for SLC38A11 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC38A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006865 amino acid transport IEA --
genes like me logo Genes that share ontologies with SLC38A11: view

No data available for Pathways by source and SIGNOR curated interactions for SLC38A11 Gene

Drugs & Compounds for SLC38A11 Gene

(1) Additional Compounds for SLC38A11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC38A11: view

Transcripts for SLC38A11 Gene

Unigene Clusters for SLC38A11 Gene

Solute carrier family 38, member 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A11 Gene

No ASD Table

Relevant External Links for SLC38A11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC38A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC38A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SLC38A11 Gene:


SOURCE GeneReport for Unigene cluster for SLC38A11 Gene:

genes like me logo Genes that share expression patterns with SLC38A11: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLC38A11 Gene

Orthologs for SLC38A11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC38A11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC38A11 34 35
  • 99.51 (n)
(Canis familiaris)
Mammalia SLC38A11 34 35
  • 88.1 (n)
(Bos Taurus)
Mammalia SLC38A11 34 35
  • 87.85 (n)
(Mus musculus)
Mammalia Slc38a11 34 16 35
  • 84.56 (n)
(Rattus norvegicus)
Mammalia Slc38a11 34
  • 82.1 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
-- 35
  • 66 (a)
-- 35
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia SLC38A11 35
  • 67 (a)
(Gallus gallus)
Aves SLC38A11 34 35
  • 72.27 (n)
(Anolis carolinensis)
Reptilia SLC38A11 35
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc38a11 34
  • 66.32 (n)
(Danio rerio)
Actinopterygii LOC100536170 34
  • 61.2 (n)
slc38a11 35 35
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005983 34
  • 47.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13743 34 35
  • 45.66 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT2 34 35 37
  • 45.45 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR671W 34
  • 44.32 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C02277g 34
  • 43.87 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01481 34
  • 47.48 (n)
Species where no ortholog for SLC38A11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC38A11 Gene

Gene Tree for SLC38A11 (if available)
Gene Tree for SLC38A11 (if available)

Paralogs for SLC38A11 Gene

Paralogs for SLC38A11 Gene

genes like me logo Genes that share paralogs with SLC38A11: view

Variants for SLC38A11 Gene

Sequence variations from dbSNP and Humsavar for SLC38A11 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10164999 -- 164,950,455(+) TGCTT(C/T)CATTT intron-variant
rs10165325 -- 164,950,743(+) TTTCA(C/T)AACAT intron-variant
rs10168496 -- 164,951,557(+) ATGCC(C/T)CTCTA intron-variant
rs10169509 -- 164,948,481(+) TAAAT(A/T)GATCT intron-variant
rs10169539 -- 164,948,570(+) ACTCT(A/G)TTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC38A11 Gene

Variant ID Type Subtype PubMed ID
nsv834444 CNV gain 17160897

Variation tolerance for SLC38A11 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC38A11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC38A11 Gene

Disorders for SLC38A11 Gene

Relevant External Links for SLC38A11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC38A11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC38A11 Gene

Publications for SLC38A11 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai D.C. … Hagoort P. (Genes Brain Behav. 2014) 3 64
  4. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. (PMID: 23506890) SchiAPth H.B. … Fredriksson R. (Mol. Aspects Med. 2013) 3 64
  5. Web-based, participant-driven studies yield novel genetic associations for common traits. (PMID: 20585627) Eriksson N. … Mountain J. (PLoS Genet. 2010) 46 64

Products for SLC38A11 Gene

Sources for SLC38A11 Gene

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