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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC38A11 Gene

protein-coding GIFtS: 44
GCID: GC02M165754

solute carrier family 38, member 11

Search for SLC38A11
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 38, Member 11¹ ²
AVT2¹ ² ³
FLJ39822¹
Putative Sodium-Coupled Neutral Amino Acid Transporter 11²

External Ids:	HGNC: 26836¹	Entrez Gene: 151258²	Ensembl: ENSG00000169507⁷	UniProtKB: Q08AI6³

Export aliases for SLC38A11 gene to outside databases

Previous GC identifers: GC02M165464 GC02M157637

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: S38AB_HUMAN, Q08AI6

Function: Putative sodium-dependent amino acid/proton antiporter (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC38A11 gene promoter:
AML1a POU3F1 Nkx2-5 C/EBPalpha Evi-1 FOXL1 RORalpha1 CHOP-10 CP2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC38A11 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC38A11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC38A11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.3 Ensembl cytogenetic band: 2q24.3 HGNC cytogenetic band: 2q24.3

SLC38A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC38A11 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M165754: view genomic region (about GC identifiers)

Start:	165,752,696 bp from pter	End:	165,812,035 bp from pter
Size:	59,340 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S38AB_HUMAN, Q08AI6 (See protein sequence)

Recommended Name: Putative sodium-coupled neutral amino acid transporter 11

Size: 406 amino acids; 44825 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: B4DF99 Q8N887

Alternative splicing: 2 isoforms: Q08AI6-1 Q08AI6-2

Explore the universe of human proteins at neXtProt for SLC38A11: NX_Q08AI6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q08AI6

SLC38A11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001186077.1 NP_775783.1

ENSEMBL proteins:

ENSP00000306178 ENSP00000386272 ENSP00000387345 ENSP00000386774 ENSP00000401448

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	Uscn Proteins for SLC38A11

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

SLC38A11 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC38A11 for domains About GeneDecksing

1 InterPro domain/family:

IPR013057 AA_transpt_TM

Graphical View of Domain Structure for InterPro Entry Q08AI6

ProtoNet protein and cluster: Q08AI6

UniProtKB/Swiss-Prot: S38AB_HUMAN, Q08AI6

Similarity: Belongs to the amino acid/polyamine transporter 2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: S38AB_HUMAN, Q08AI6

Function: Putative sodium-dependent amino acid/proton antiporter (By similarity)

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC38A11

5 Interacting proteins for SLC38A11 (Q08AI6³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARFGAP1	Q8N6T3³	I2D: score=5
TBL1XR1	Q9BZK7³	I2D: score=4
HSP90AA1	P07900³	I2D: score=1
UBC	P0CG48³	I2D: score=1
WDR36	Q8NI36³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006814	sodium ion transport	IEA	--
GO:0006865	amino acid transport	IEA	--

SLC38A11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC38A11

1 HMDB Compound for SLC38A11 About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--

Search CenterWatch for drugs/clinical trials and news about SLC38A11 / S38AB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC38A11 gene (2 alternative transcripts):

NM_001199148.1 NM_173512.2

Unigene Cluster for SLC38A11:

Solute carrier family 38, member 11

Hs.658702 [show with all ESTs]

Unigene Representative Sequence: NM_001199148

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000303735(uc002ucw.2 uc002ucu.2 uc002ucv.2) ENST00000409149

ENST00000409058 ENST00000409662 ENST00000483641 ENST00000470576 ENST00000424914

ENST00000493887 ENST00000465898 ENST00000492134

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Additional cDNA sequence:

AK097141.1 AK293998.1 BC125156.1 BC125157.1

4 DOTS entries:

DT.86849184 DT.40130266 DT.439084 DT.97784096

21 AceView cDNA sequences:

CD672687 CA389372 CA391349 NM_173512 CA389371 CA390853 AK097141 BM696864

N92203 BX111853 AA746060 AA985184 N62096 AA984158 AI675023 AJ239465

AK130292 AW338091 AA558022 N78327 AW949159

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC38A11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCAGCAGAC

About this image

SLC38A11 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC38A11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC38A11

SOURCE GeneReport for Unigene cluster: Hs.658702

SABiosciences Custom PCR Arrays for SLC38A11

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC38A11 gene from 5/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC38A11¹	solute carrier family 38, member 11	72.27(n) 70.28(a)		424181 XM_422027.3 XP_422027.3
lizard (Anolis carolinensis)	Reptilia	SLC38A11⁶	--	59(a)	1 ↔ 1	GL343214.1(1670468-1694502)
zebrafish (Danio rerio)	Actinopterygii	LOC100536170¹	putative sodium-coupled neutral amino acid transporter more	60.83(n) 59.75(a)		100536170 XM_003199249.1 XP_003199297.1
fruit fly (Drosophila melanogaster)	Insecta	CG13743¹	CG13743	45.67(n) 38.61(a)		35911 NM_136600.1 NP_610444.2
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	AVT2(YEL064C)⁴ AVT2¹	Putative transporter, member of a family of seven S. more⁴ Avt2p¹	45.02(n)¹ 31.23(a)¹		5(31239-29797)⁴ 856645^{1, 4} NP_010850.1^{1, 4}

ENSEMBL Gene Tree for SLC38A11 (if available)
TreeFam Gene Tree for SLC38A11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC38A11 gene

SLC38A4² SLC38A6² SLC38A1² SLC38A2² SLC38A5² SLC38A10²

SLC38A11 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147677370^1,2		--	165754479(+)	`TCCTCG/TTTGTT`	2	--	ds500¹		0	--	--	--	--
rs145219043^1,2	C,	--	165754575(+)	`CCACA-/CCCCCC`	2	--	ds500¹		0	--	--	--	--
rs72884433^1,2	C,	--	165754611(+)	`TTCCAA/TCCCAC`	2	--	ds500¹		4		NA WA EA	360
rs184720085^1,2		--	165754682(+)	`GCAGAA/CAATGC`	2	--	ds500¹		0	--	--	--	--
rs190001026^1,2		--	165754705(+)	`TCTCCC/TTTCTT`	2	--	ds500¹		0	--	--	--	--
rs200670832^1,2		--	165754925(+)	`AACATA/GCATAT`	2	--	ut3¹		0	--	--	--	--
rs73015592^1,2	C,F,	--	165754983(+)	`AGTTGT/CGTTGT`	4	/T	syn¹		5		WA CSA NA EU	5977
rs149234782^1,2	C,F,	--	165755007(+)	`GACTCT/CGAGGT`	4	/S	syn¹		1		NA	4550
rs142178695^1,2	C,F	--	165755135(+)	`AAGCAT/CGACAC`	4	/M /V	mis¹		2		NA EU	5873
rs148795906^1,2	C,	--	165755156(+)	`CTTATC/TGGAGT`	4	N D	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC38A11 (165752696 - 165812035 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC38A11
1 CNV: 4316

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC38A11 for disorders About MalaCards

SLC38A11 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: SLC38A11 (1 document)

Export disorders for SLC38A11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC38A11 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC38A11)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 151258	HGNC: 26836	AceView: FLJ39822	Ensembl:ENSG00000169507	euGenes: HUgn151258
ECgene: SLC38A11	H-InvDB: SLC38A11

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC38A11	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC38A11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SLC38A11 gene:
Search GeneIP for patents involving SLC38A11

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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SLC38A11 Gene

solute carrier family 38, member 11

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SLC38A11 Gene

solute carrier family 38, member 11

Aliasesfor SLC38A11 gene

Summariesfor SLC38A11 gene

Genomic Viewsfor SLC38A11 gene

Proteinsfor SLC38A11 gene

Protein Domains /Familiesfor SLC38A11 gene

Functionfor SLC38A11 gene

Pathways & Interactionsfor SLC38A11 gene

Drugs & Compoundsfor SLC38A11 gene

Transcriptsfor SLC38A11 gene

Expression for SLC38A11 gene

Orthologsfor SLC38A11 gene

Paralogsfor SLC38A11 gene

Genomic Variantsfor SLC38A11 gene

Disorders / Diseasesfor SLC38A11 gene

Publicationsfor SLC38A11 gene

External Searches for SLC38A11 gene

Genome Databases showing SLC38A11 gene

Other Databases showing SLC38A11 gene

Specialized Databases showing SLC38A11 gene

Intellectual Propertyfor SLC38A11 gene

Productsfor SLC38A11 gene

View Random Gene

Aliases
for SLC38A11 gene

Summaries
for SLC38A11 gene

Genomic Views
for SLC38A11 gene

Proteins
for SLC38A11 gene

Protein Domains /
Families
for SLC38A11 gene

Function
for SLC38A11 gene

Pathways & Interactions
for SLC38A11 gene

Drugs & Compounds
for SLC38A11 gene

Transcripts
for SLC38A11 gene

Expression
for SLC38A11 gene

Orthologs
for SLC38A11 gene

Paralogs
for SLC38A11 gene

Genomic Variants
for SLC38A11 gene

Disorders / Diseases
for SLC38A11 gene

Publications
for SLC38A11 gene

Intellectual Property
for SLC38A11 gene

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for SLC38A11 gene