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Aliases for SLC38A10 Gene

Aliases for SLC38A10 Gene

  • Solute Carrier Family 38 Member 10 2 3 4 5
  • Putative Sodium-Coupled Neutral Amino Acid Transporter 10 3
  • Solute Carrier Family 38, Member 10 2
  • PP1744 3

External Ids for SLC38A10 Gene

Previous GeneCards Identifiers for SLC38A10 Gene

  • GC17M076834
  • GC17M079218
  • GC17M074654

Summaries for SLC38A10 Gene

GeneCards Summary for SLC38A10 Gene

SLC38A10 (Solute Carrier Family 38 Member 10) is a Protein Coding gene. GO annotations related to this gene include amino acid transmembrane transporter activity. An important paralog of this gene is SLC38A2.

UniProtKB/Swiss-Prot for SLC38A10 Gene

  • Putative sodium-dependent amino acid/proton antiporter.

Gene Wiki entry for SLC38A10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A10 Gene

Genomics for SLC38A10 Gene

Regulatory Elements for SLC38A10 Gene

Enhancers for SLC38A10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F081294 1.1 ENCODE 38.5 +0.1 117 2.7 HDGF ARNT ZFP64 ARID4B SIN3A YY1 ZNF143 SP3 SP5 NFYC SLC38A10 CHMP6 TEPSIN HGS ENSG00000262049 NPLOC4 NDUFAF8 ALYREF ENSG00000265678 SIRT7
GH17F081284 1.2 FANTOM5 ENCODE 33.6 +8.8 8783 3.8 ATF1 CBX3 CREB3L1 SIN3A YY1 ZNF143 SMAD5 ZBTB11 ELF1 NR2F2 SLC38A10 TMEM105 CEP131 LOC100294362 ENSG00000262049 LINC00482 GPS1 ENSG00000265678 ARL16 RFNG
GH17F081089 1.7 FANTOM5 Ensembl ENCODE 11.8 +201.2 201238 8.8 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF766 ENSG00000262049 LOC100294362 ARL16 HGS EIF4A3 CEP131 ALYREF TEPSIN GPS1 SLC38A10
GH17F081336 1.5 FANTOM5 ENCODE 12.9 -46.4 -46397 10.8 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TMEM105 ENSG00000262049 RFNG LINC00482 CEP131 TSPAN10 SLC38A10 HGS ENSG00000265678 ARL16
GH17F081452 1.6 FANTOM5 Ensembl ENCODE 11.8 -162.6 -162556 10.4 ZNF493 ZFP64 GLIS2 ELK1 ZNF548 FOS ZNF263 ZNF202 SP3 YY2 ENSG00000262049 OGFOD3 CEP131 RFNG HGS ENSG00000265678 TSPAN10 ENSG00000262877 TEPSIN ENSG00000229848
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC38A10 on UCSC Golden Path with GeneCards custom track

Promoters for SLC38A10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001355209 647 2201 HDGF ARNT ZFP64 ARID4B SIN3A YY1 ZNF143 SP3 SP5 NFYC

Genomic Location for SLC38A10 Gene

81,244,811 bp from pter
81,295,547 bp from pter
50,737 bases
Minus strand

Genomic View for SLC38A10 Gene

Genes around SLC38A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC38A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC38A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A10 Gene

Proteins for SLC38A10 Gene

  • Protein details for SLC38A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative sodium-coupled neutral amino acid transporter 10
    Protein Accession:
    Secondary Accessions:
    • Q6ZRC5
    • Q8NA99
    • Q96C66

    Protein attributes for SLC38A10 Gene

    1119 amino acids
    Molecular mass:
    119762 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG17235.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04027.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC38A10 Gene


neXtProt entry for SLC38A10 Gene

Post-translational modifications for SLC38A10 Gene

  • Glycosylation at Ser 429, Ser 524, Ser 795, Ser 802, Ser 806, Thr 886, Thr 902, Thr 921, Ser 997, and Ser 1106
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC38A10 Gene

Domains & Families for SLC38A10 Gene

Gene Families for SLC38A10 Gene

Protein Domains for SLC38A10 Gene


Suggested Antigen Peptide Sequences for SLC38A10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the amino acid/polyamine transporter 2 family.
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A10: view

Function for SLC38A10 Gene

Molecular function for SLC38A10 Gene

UniProtKB/Swiss-Prot Function:
Putative sodium-dependent amino acid/proton antiporter.

Gene Ontology (GO) - Molecular Function for SLC38A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC38A10: view
genes like me logo Genes that share phenotypes with SLC38A10: view

Animal Models for SLC38A10 Gene

MGI Knock Outs for SLC38A10:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC38A10

miRNA for SLC38A10 Gene

miRTarBase miRNAs that target SLC38A10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC38A10 Gene

Localization for SLC38A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC38A10 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
nucleus 2

Gene Ontology (GO) - Cellular Components for SLC38A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC38A10: view

Pathways & Interactions for SLC38A10 Gene

SuperPathways for SLC38A10 Gene

No Data Available

Interacting Proteins for SLC38A10 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)
Selected Interacting proteins: Q9HBR0-S38AA_HUMAN ENSP00000363891 for SLC38A10 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SLC38A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006865 amino acid transport IEA --
genes like me logo Genes that share ontologies with SLC38A10: view

No data available for Pathways by source and SIGNOR curated interactions for SLC38A10 Gene

Drugs & Compounds for SLC38A10 Gene

(1) Additional Compounds for SLC38A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC38A10: view

Transcripts for SLC38A10 Gene

Unigene Clusters for SLC38A10 Gene

Solute carrier family 38, member 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A10 Gene

No ASD Table

Relevant External Links for SLC38A10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC38A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC38A10 Gene

Protein differential expression in normal tissues from HIPED for SLC38A10 Gene

This gene is overexpressed in Adrenal (34.3), Pancreas (8.2), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC38A10 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC38A10 Gene:


SOURCE GeneReport for Unigene cluster for SLC38A10 Gene:

genes like me logo Genes that share expression patterns with SLC38A10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLC38A10 Gene

Orthologs for SLC38A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC38A10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC38A10 34
  • 97.62 (n)
(Ornithorhynchus anatinus)
Mammalia SLC38A10 35
  • 90 (a)
(Bos Taurus)
Mammalia SLC38A10 34 35
  • 79.58 (n)
(Canis familiaris)
Mammalia SLC38A10 34 35
  • 78.49 (n)
(Mus musculus)
Mammalia Slc38a10 34 16 35
  • 76.66 (n)
(Rattus norvegicus)
Mammalia Slc38a10 34
  • 76.23 (n)
(Monodelphis domestica)
Mammalia SLC38A10 35
  • 59 (a)
(Gallus gallus)
Aves SLC38A10 34 35
  • 64.94 (n)
(Anolis carolinensis)
Reptilia SLC38A10 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc38a10 34
  • 66.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69139 34
(Danio rerio)
Actinopterygii slc38a10 35
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30394 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea Y51F10.4 34 35
  • 45.55 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT2 35
  • 20 (a)
AVT5 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
Species where no ortholog for SLC38A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC38A10 Gene

Gene Tree for SLC38A10 (if available)
Gene Tree for SLC38A10 (if available)

Paralogs for SLC38A10 Gene

Paralogs for SLC38A10 Gene

genes like me logo Genes that share paralogs with SLC38A10: view

Variants for SLC38A10 Gene

Sequence variations from dbSNP and Humsavar for SLC38A10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10438816 -- 81,279,751(+) GGCAA(C/T)TGGTA intron-variant
rs10445406 -- 81,287,548(+) CTCAC(A/G)CAGTG intron-variant, upstream-variant-2KB
rs10445407 -- 81,288,009(+) AGTTG(A/C)ATTAG intron-variant, upstream-variant-2KB
rs10569617 -- 81,245,701(+) GGCCA(-/ATG)ATGAC cds-indel
rs10871494 -- 81,282,198(+) AACAT(A/G)AACAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SLC38A10 Gene

Variant ID Type Subtype PubMed ID
nsv952389 CNV deletion 24416366
nsv828128 CNV loss 20364138
nsv576172 CNV loss 21841781
nsv509677 CNV insertion 20534489
nsv470619 CNV loss 18288195
nsv457971 CNV loss 19166990
nsv428351 CNV gain 18775914
nsv2161 CNV insertion 18451855
nsv1160499 CNV deletion 26073780
nsv1142232 CNV tandem duplication 24896259
nsv1064123 CNV gain 25217958
esv997494 CNV insertion 20482838
esv987875 CNV insertion 20482838
esv3893051 CNV gain 25118596
esv3641394 CNV loss 21293372
esv3554878 CNV deletion 23714750
esv3357817 CNV duplication 20981092
esv2758707 CNV gain 17122850
esv2716445 CNV deletion 23290073
esv2716444 CNV deletion 23290073
esv26223 CNV gain+loss 19812545
dgv46n68 CNV loss 17160897

Variation tolerance for SLC38A10 Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.46; 99.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC38A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC38A10 Gene

Disorders for SLC38A10 Gene

Relevant External Links for SLC38A10

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC38A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC38A10 Gene

Publications for SLC38A10 Gene

  1. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin A.I. … Ukraintseva S.V. (Aging (Albany NY) 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for SLC38A10 Gene

Sources for SLC38A10 Gene

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