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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC38A10 Gene

protein-coding   GIFtS: 44
GCID: GC17M079218

solute carrier family 38, member 10

  Search for SLC38A10
in our new
 Human Malady Compendium 
Biological research products
for SLC38A10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 38, Member 101 2
MGC155231
PP17441
Putative Sodium-Coupled Neutral Amino Acid Transporter 102

External Ids:    HGNC: 282371   Entrez Gene: 1245652   Ensembl: ENSG000001576377   UniProtKB: Q9HBR03   

Export aliases for SLC38A10 gene to outside databases

Previous GC identifers: GC17M076834 GC17M074654


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: S38AA_HUMAN, Q9HBR0
Function: Putative sodium-dependent amino acid/proton antiporter (By similarity)

Gene Wiki entry for SLC38A10


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC38A10 gene promoter:
         GR   AP-2gamma   GATA-2   HEN1   FOXO4   AP-2beta   GR-alpha   AP-2alpha   ATF   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC38A10 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC38A10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC38A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

SLC38A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC38A10 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079218:  view genomic region     (about GC identifiers)

Start:
79,218,799 bp from pter      End:
79,269,347 bp from pter
Size:
50,549 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S38AA_HUMAN, Q9HBR0 (See protein sequence)
Recommended Name: Putative sodium-coupled neutral amino acid transporter 10  
Size: 1119 amino acids; 119762 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAG17235.1; Type=Erroneous initiation; Sequence=BAC04027.1; Type=Erroneous initiation;
Secondary accessions: Q6ZRC5 Q8NA99 Q96C66
Alternative splicing: 3 isoforms:  Q9HBR0-1   Q9HBR0-2   Q9HBR0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC38A10: NX_Q9HBR0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HBR0

  • SLC38A10 Protein expression data from MOPED and PaxDb:    About this image 
    SLC38A10 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001033073.1  NP_612637.1  

    ENSEMBL proteins: 
     ENSP00000363891   ENSP00000437601   ENSP00000458273   ENSP00000288439   ENSP00000444523  
     ENSP00000439115  

    Human Recombinant Protein Products for SLC38A10: 
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    Uscn Proteins for SLC38A10

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    SLC38A10 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC38A10


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC38A10 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR013057 AA_transpt_TM

    Graphical View of Domain Structure for InterPro Entry Q9HBR0

    ProtoNet protein and cluster: Q9HBR0

    UniProtKB/Swiss-Prot: S38AA_HUMAN, Q9HBR0
    Similarity: Belongs to the amino acid/polyamine transporter 2 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S38AA_HUMAN, Q9HBR0
    Function: Putative sodium-dependent amino acid/proton antiporter (By similarity)

    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc38a10):

     adipose tissue  behavior/neurological  growth/size  hematopoietic system  homeostasis/metabolism 
     integument  other  skeleton  vision/eye 

    SLC38A10 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC38A10 

    miRNA
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC38A10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC38A10 (ENSP000003638914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006814sodium ion transport IEA--
    GO:0006865amino acid transport IEA--

    SLC38A10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC38A10

    1 HMDB Compound for SLC38A10    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--
    Search CenterWatch for drugs/clinical trials and news about SLC38A10 / S38AA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC38A10 gene (2 alternative transcripts): 
    NM_001037984.1  NM_138570.2  

    Unigene Cluster for SLC38A10:

    Solute carrier family 38, member 10
    Hs.352240  [show with all ESTs]
    Unigene Representative Sequence: NM_001037984
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374759(uc002jzy.1 uc002jzz.1) ENST00000539643 ENST00000540966
    ENST00000576151 ENST00000542075 ENST00000573058 ENST00000288439(uc002kab.3)
    ENST00000546352 ENST00000543204 ENST00000539748 ENST00000540233

    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC38A10
    Sirion Biotech Custom design and validation of potent shRNA sequences against SLC38A10 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC38A10 (see all 8)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC38A10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC38A10

    Additional cDNA sequence: 

    AF086389.1 AF217993.1 AK093037.1 AK098424.1 BC007391.2 BC011702.2 BC014156.2 BC014642.1 
    BC020925.1 

    14 DOTS entries:

    DT.100816934  DT.408200  DT.95363609  DT.100816932  DT.91975041  DT.97814522  DT.100032614  DT.97854815 
    DT.120998264  DT.91944130  DT.120998265  DT.97825407  DT.101964670  DT.120998257 

    24/325 AceView cDNA sequences (see all 325):

    BU855825 CD107201 AI913144 AI653159 BC014642 BU149478 BQ057819 AA483848 
    AA653692 CK819592 AI654878 BC014156 AW338099 BM674474 AW438884 AK093037 
    BU538752 BQ056661 BM694899 BQ066344 BM546967 BQ066349 BM008623 NM_138570 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC38A10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCCCAACAC
    SLC38A10 Expression
    About this image

    SLC38A10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeAdipose
    BoneMandibular CondyleBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC38A10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC38A10

    SOURCE GeneReport for Unigene cluster: Hs.352240
        SABiosciences Custom PCR Arrays for SLC38A10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC38A10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC38A10 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLC38A106
    Uncharacterized protein
    48(a)
    1 ↔ 1
    18(9220381-9250854)
    lizard
    (Anolis carolinensis)
    Reptilia SLC38A106
    --
    84(a)
    1 ↔ 1
    2(99204747-99262945)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691392 hypothetical protein MGC69139 76.15(n)    BC059341.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc38a101 solute carrier family 38, member 10 63.91(n)
    61.84(a)
      561739  XM_685145.5  XP_690237.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG303941 CG30394 44.89(n)
    29.72(a)
      37437  NM_137734.2  NP_611578.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y51F10.41 Protein Y51F10.4 44.31(n)
    32.09(a)
      245996  NM_001037899.1  NP_001032988.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G562001 transmembrane amino acid transporter-like protein 43.03(n)
    29.35(a)
      824786  NM_115478.6  NP_191179.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g08258001 hypothetical protein 48.22(n)
    27.16(a)
      4327515  NM_001051207.1  NP_001044672.2 


    ENSEMBL Gene Tree for SLC38A10 (if available)
    TreeFam Gene Tree for SLC38A10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC38A10 gene
    SLC38A42  SLC38A62  SLC38A12  SLC38A22  SLC38A52  SLC38A112  

    SLC38A10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1033 NCBI SNPs in SLC38A10 are shown (see all 1033    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs793392781,2
    C,F--79218317(+) GTGGAC/TACAGC 1 -- int11Minor allele frequency- T:0.02EA 120
    rs1810341061,2
    --79218349(+) GGTGAA/GAGGGC 1 -- int10--------
    rs1142051581,2
    F--79218376(+) GTCACG/AAGGCA 1 -- int11Minor allele frequency- A:0.07WA 118
    rs752774451,2
    C--79218433(+) CAGGCG/AGCTCT 1 -- int12Minor allele frequency- A:0.04CSA WA 120
    rs1508353401,2
    --79218440(+) CTCTGA/CCTGCT 1 -- int10--------
    rs733560941,2
    C--79218495(+) TGCGAC/TGCTCA 1 -- int12Minor allele frequency- T:0.08WA 120
    rs1134216151,2
    --79218628(+) TGGTGT/GTTTTT 1 -- int12Minor allele frequency- G:0.05CSA WA 120
    rs1392584371,2
    --79218654(+) CCACAA/GTTGGA 1 -- int10--------
    rs26590051,2
    C,F,A,H--79218714(-) GTGCCA/GCCCTT 1 -- int121Minor allele frequency- G:0.43EA NS NA 3194
    rs559788261,2
    C--79218733(+) GCCCC-/TTGGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for SLC38A10 (79218799 - 79269347 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for SLC38A10
         4 CNVs: 73071 30032 4048 30033

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SLC38A10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC38A10 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLC38A10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    3. Joint influence of small-effect genetic variants on h uman longevity. (PubMed id 20834067)1 Yashin A.I....Ukraintseva S.V. (2010)
    4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)2 Wan D....Gu J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 124565 HGNC: 28237 AceView: MGC15523 Ensembl:ENSG00000157637 euGenes: HUgn124565
    ECgene: SLC38A10 H-InvDB: SLC38A10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC38A10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC38A10 gene:
    Search GeneIP for patents involving SLC38A10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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