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Aliases for SLC38A10 Gene

Aliases for SLC38A10 Gene

  • Solute Carrier Family 38 Member 10 2 3 4 5
  • Putative Sodium-Coupled Neutral Amino Acid Transporter 10 3
  • Solute Carrier Family 38, Member 10 2
  • PP1744 3

External Ids for SLC38A10 Gene

Previous GeneCards Identifiers for SLC38A10 Gene

  • GC17M076834
  • GC17M079218
  • GC17M074654

Summaries for SLC38A10 Gene

GeneCards Summary for SLC38A10 Gene

SLC38A10 (Solute Carrier Family 38 Member 10) is a Protein Coding gene. GO annotations related to this gene include amino acid transmembrane transporter activity. An important paralog of this gene is SLC38A2.

UniProtKB/Swiss-Prot for SLC38A10 Gene

  • Putative sodium-dependent amino acid/proton antiporter.

Gene Wiki entry for SLC38A10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A10 Gene

Genomics for SLC38A10 Gene

Regulatory Elements for SLC38A10 Gene

Enhancers for SLC38A10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SLC38A10 on UCSC Golden Path with GeneCards custom track

Promoters for SLC38A10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC38A10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC38A10 Gene

Chromosome:
17
Start:
81,244,811 bp from pter
End:
81,295,547 bp from pter
Size:
50,737 bases
Orientation:
Minus strand

Genomic View for SLC38A10 Gene

Genes around SLC38A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC38A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC38A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A10 Gene

Proteins for SLC38A10 Gene

  • Protein details for SLC38A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBR0-S38AA_HUMAN
    Recommended name:
    Putative sodium-coupled neutral amino acid transporter 10
    Protein Accession:
    Q9HBR0
    Secondary Accessions:
    • Q6ZRC5
    • Q8NA99
    • Q96C66

    Protein attributes for SLC38A10 Gene

    Size:
    1119 amino acids
    Molecular mass:
    119762 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG17235.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04027.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC38A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC38A10 Gene

Post-translational modifications for SLC38A10 Gene

  • Glycosylation at Ser 429, Ser 524, Ser 795, Ser 802, Ser 806, Thr 886, Thr 902, Thr 921, Ser 997, and Ser 1106
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC38A10 Gene

No data available for DME Specific Peptides for SLC38A10 Gene

Domains & Families for SLC38A10 Gene

Gene Families for SLC38A10 Gene

Protein Domains for SLC38A10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC38A10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBR0

UniProtKB/Swiss-Prot:

S38AA_HUMAN :
  • Belongs to the amino acid/polyamine transporter 2 family.
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A10: view

Function for SLC38A10 Gene

Molecular function for SLC38A10 Gene

UniProtKB/Swiss-Prot Function:
Putative sodium-dependent amino acid/proton antiporter.

Gene Ontology (GO) - Molecular Function for SLC38A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC38A10: view
genes like me logo Genes that share phenotypes with SLC38A10: view

Animal Models for SLC38A10 Gene

MGI Knock Outs for SLC38A10:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC38A10

CRISPR Products

miRNA for SLC38A10 Gene

miRTarBase miRNAs that target SLC38A10

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC38A10 Gene

Localization for SLC38A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC38A10 Gene COMPARTMENTS Subcellular localization image for SLC38A10 gene
Compartment Confidence
golgi apparatus 3
plasma membrane 3
nucleus 2

Gene Ontology (GO) - Cellular Components for SLC38A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC38A10: view

Pathways & Interactions for SLC38A10 Gene

SuperPathways for SLC38A10 Gene

No Data Available

Interacting Proteins for SLC38A10 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363891%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000366942%0d%0a9606.ENSP00000243389%0d%0a9606.ENSP00000317382%0d%0a9606.ENSP00000334223%0d%0a
Selected Interacting proteins: ENSP00000363891 Q9HBR0-S38AA_HUMAN for SLC38A10 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC38A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006814 sodium ion transport IEA --
GO:0006865 amino acid transport IEA --
GO:0060348 bone development IEA --
genes like me logo Genes that share ontologies with SLC38A10: view

No data available for Pathways by source and SIGNOR curated interactions for SLC38A10 Gene

Drugs & Compounds for SLC38A10 Gene

(1) Additional Compounds for SLC38A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC38A10: view

Transcripts for SLC38A10 Gene

Unigene Clusters for SLC38A10 Gene

Solute carrier family 38, member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A10 Gene

No ASD Table

Relevant External Links for SLC38A10 Gene

GeneLoc Exon Structure for
SLC38A10
ECgene alternative splicing isoforms for
SLC38A10

Expression for SLC38A10 Gene

mRNA expression in normal human tissues for SLC38A10 Gene

Protein differential expression in normal tissues from HIPED for SLC38A10 Gene

This gene is overexpressed in Adrenal (34.3), Pancreas (8.2), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC38A10 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC38A10 Gene:

SLC38A10

SOURCE GeneReport for Unigene cluster for SLC38A10 Gene:

Hs.352240
genes like me logo Genes that share expression patterns with SLC38A10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLC38A10 Gene

Orthologs for SLC38A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC38A10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC38A10 34
  • 79.58 (n)
  • 73.99 (a)
SLC38A10 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC38A10 34
  • 78.49 (n)
  • 72.48 (a)
SLC38A10 35
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc38a10 34
  • 76.66 (n)
  • 72.18 (a)
Slc38a10 16
Slc38a10 35
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC38A10 34
  • 97.62 (n)
  • 97.07 (a)
rat
(Rattus norvegicus)
Mammalia Slc38a10 34
  • 76.23 (n)
  • 70.93 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC38A10 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC38A10 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC38A10 34
  • 64.94 (n)
  • 60.24 (a)
SLC38A10 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC38A10 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc38a10 34
  • 66.92 (n)
  • 68.03 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69139 34
zebrafish
(Danio rerio)
Actinopterygii slc38a10 35
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30394 35
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y51F10.4 34
  • 45.55 (n)
  • 34.03 (a)
Y51F10.4 35
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT2 35
  • 20 (a)
OneToMany
AVT5 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
Species where no ortholog for SLC38A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC38A10 Gene

ENSEMBL:
Gene Tree for SLC38A10 (if available)
TreeFam:
Gene Tree for SLC38A10 (if available)

Paralogs for SLC38A10 Gene

Paralogs for SLC38A10 Gene

genes like me logo Genes that share paralogs with SLC38A10: view

Variants for SLC38A10 Gene

Sequence variations from dbSNP and Humsavar for SLC38A10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2725405 - 81,246,424(-) CCAGG(C/G)CAAGC reference, missense
rs35546507 - 81,252,464(+) GCCTC(C/T)TCCCA reference, missense
rs884028 -- 81,256,987(+) GGGAG(G/T)CGGGA intron-variant
rs2271090 -- 81,272,805(-) CCGTT(C/T)AAGTT intron-variant
rs2279910 -- 81,281,073(+) GCTGG(C/T)TTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC38A10 Gene

Variant ID Type Subtype PubMed ID
dgv46n68 CNV loss 17160897
esv26223 CNV gain+loss 19812545
esv2716444 CNV deletion 23290073
esv2716445 CNV deletion 23290073
esv2758707 CNV gain 17122850
esv3357817 CNV duplication 20981092
esv3554878 CNV deletion 23714750
esv3641394 CNV loss 21293372
esv3893051 CNV gain 25118596
esv987875 CNV insertion 20482838
esv997494 CNV insertion 20482838
nsv1064123 CNV gain 25217958
nsv1142232 CNV tandem duplication 24896259
nsv1160499 CNV deletion 26073780
nsv2161 CNV insertion 18451855
nsv428351 CNV gain 18775914
nsv457971 CNV loss 19166990
nsv470619 CNV loss 18288195
nsv509677 CNV insertion 20534489
nsv576172 CNV loss 21841781
nsv828128 CNV loss 20364138
nsv952389 CNV deletion 24416366

Variation tolerance for SLC38A10 Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.46; 99.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC38A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC38A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC38A10 Gene

Disorders for SLC38A10 Gene

Relevant External Links for SLC38A10

Genetic Association Database (GAD)
SLC38A10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC38A10

No disorders were found for SLC38A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC38A10 Gene

Publications for SLC38A10 Gene

  1. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin A.I. … Ukraintseva S.V. (Aging (Albany NY) 2010) 3 46 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65

Products for SLC38A10 Gene

Sources for SLC38A10 Gene

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