Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC37A3 Gene

Aliases for SLC37A3 Gene

  • Solute Carrier Family 37, Member 3 2 3
  • Solute Carrier Family 37 Member 3 4
  • SPX3 4

External Ids for SLC37A3 Gene

Previous GeneCards Identifiers for SLC37A3 Gene

  • GC07M138305
  • GC07M139363
  • GC07M139440
  • GC07M139486
  • GC07M139680
  • GC07M139993
  • GC07M134326

Summaries for SLC37A3 Gene

GeneCards Summary for SLC37A3 Gene

SLC37A3 (Solute Carrier Family 37, Member 3) is a Protein Coding gene. GO annotations related to this gene include transporter activity and transmembrane transporter activity. An important paralog of this gene is SLC37A2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC37A3 Gene

Genomics for SLC37A3 Gene

Regulatory Elements for SLC37A3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC37A3 Gene

Chromosome:
7
Start:
140,293,693 bp from pter
End:
140,404,433 bp from pter
Size:
110,741 bases
Orientation:
Minus strand

Genomic View for SLC37A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC37A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC37A3 Gene

Proteins for SLC37A3 Gene

  • Protein details for SLC37A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCC5-SPX3_HUMAN
    Recommended name:
    Sugar phosphate exchanger 3
    Protein Accession:
    Q8NCC5
    Secondary Accessions:
    • Q6PIU7
    • Q86SS4
    • Q9BQG7

    Protein attributes for SLC37A3 Gene

    Size:
    494 amino acids
    Molecular mass:
    54486 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC37A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC37A3 Gene

Proteomics data for SLC37A3 Gene at MOPED

Post-translational modifications for SLC37A3 Gene

  • Glycosylation at Asn 58 and Asn 266

No data available for DME Specific Peptides for SLC37A3 Gene

Domains & Families for SLC37A3 Gene

Gene Families for SLC37A3 Gene

Protein Domains for SLC37A3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NCC5

UniProtKB/Swiss-Prot:

SPX3_HUMAN :
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
Family:
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
genes like me logo Genes that share domains with SLC37A3: view

Function for SLC37A3 Gene

Gene Ontology (GO) - Molecular Function for SLC37A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0015315 organophosphate:inorganic phosphate antiporter activity IBA --
genes like me logo Genes that share ontologies with SLC37A3: view

Phenotypes for SLC37A3 Gene

GenomeRNAi human phenotypes for SLC37A3:
genes like me logo Genes that share phenotypes with SLC37A3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC37A3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC37A3 Gene

Localization for SLC37A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC37A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC37A3 Gene COMPARTMENTS Subcellular localization image for SLC37A3 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC37A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC37A3: view

Pathways & Interactions for SLC37A3 Gene

SuperPathways for SLC37A3 Gene

No Data Available

Interacting Proteins for SLC37A3 Gene

Gene Ontology (GO) - Biological Process for SLC37A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006820 anion transport IBA --
GO:0008643 carbohydrate transport IEA --
GO:0035435 phosphate ion transmembrane transport IBA --
GO:0055062 phosphate ion homeostasis IBA --
genes like me logo Genes that share ontologies with SLC37A3: view

No data available for Pathways by source and SIGNOR curated interactions for SLC37A3 Gene

Drugs & Compounds for SLC37A3 Gene

No Compound Related Data Available

Transcripts for SLC37A3 Gene

Unigene Clusters for SLC37A3 Gene

Solute carrier family 37 (glycerol-3-phosphate transporter), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC37A3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC37A3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b · 16c ·
SP1: - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6:
SP7: - - - - - - -
SP8:
SP9: - -

ExUns: 16d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for SLC37A3 Gene

GeneLoc Exon Structure for
SLC37A3
ECgene alternative splicing isoforms for
SLC37A3

Expression for SLC37A3 Gene

mRNA expression in normal human tissues for SLC37A3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC37A3 Gene



SOURCE GeneReport for Unigene cluster for SLC37A3 Gene Hs.446021

genes like me logo Genes that share expression patterns with SLC37A3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC37A3 Gene

Orthologs for SLC37A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC37A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC37A3 35
  • 88.19 (n)
  • 90.49 (a)
SLC37A3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC37A3 35
  • 89.41 (n)
  • 92.11 (a)
SLC37A3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc37a3 35
  • 86.17 (n)
  • 88.87 (a)
Slc37a3 16
Slc37a3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC37A3 35
  • 99.66 (n)
  • 100 (a)
SLC37A3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc37a3 35
  • 85.43 (n)
  • 90.08 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC37A3 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC37A3 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC37A3 35
  • 75.26 (n)
  • 80.62 (a)
SLC37A3 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC37A3 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc37a3 35
  • 67.84 (n)
  • 74.12 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100331554 35
  • 66.67 (n)
  • 71.28 (a)
SLC37A3 36
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T11G6.2 35
  • 53.18 (n)
  • 49.89 (a)
T10C6.6 36
  • 41 (a)
OneToMany
T11G6.2 36
  • 43 (a)
OneToMany
T11G6.3 36
  • 42 (a)
OneToMany
T11G6.4 36
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for SLC37A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC37A3 Gene

ENSEMBL:
Gene Tree for SLC37A3 (if available)
TreeFam:
Gene Tree for SLC37A3 (if available)

Paralogs for SLC37A3 Gene

Paralogs for SLC37A3 Gene

genes like me logo Genes that share paralogs with SLC37A3: view

Variants for SLC37A3 Gene

Sequence variations from dbSNP and Humsavar for SLC37A3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs558 -- 140,333,831(+) ACTGA(C/T)TGGAA utr-variant-3-prime
rs1128589 -- 140,334,494(-) CACAA(C/G)CAGCT utr-variant-3-prime
rs1139906 -- 140,334,942(-) CATCT(A/T)TGAAG utr-variant-3-prime
rs3924960 -- 140,376,009(+) GTACA(C/T)GCACC intron-variant
rs3924961 -- 140,376,090(+) TTACC(A/C/T)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC37A3 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV Deletion 23290073
nsv889247 CNV Gain 21882294
nsv522190 CNV Gain 19592680
esv1579138 CNV Insertion 17803354
esv1228695 CNV Insertion 17803354

Variation tolerance for SLC37A3 Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.29; 90.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC37A3 Gene

HapMap Linkage Disequilibrium report
SLC37A3
Human Gene Mutation Database (HGMD)
SLC37A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC37A3 Gene

Disorders for SLC37A3 Gene

Relevant External Links for SLC37A3

Genetic Association Database (GAD)
SLC37A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC37A3
genes like me logo Genes that share disorders with SLC37A3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC37A3 Gene

Publications for SLC37A3 Gene

  1. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67
  2. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. (PMID: 21752829) Palmieri M. … Ballabio A. (Hum. Mol. Genet. 2011) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. The human sugar-phosphate/phosphate exchanger family SLC37. (PMID: 12811562) Bartoloni L. … Antonarakis S.E. (Pflugers Arch. 2004) 67

Products for SLC37A3 Gene

Sources for SLC37A3 Gene

Back to Top

Content