SLC37A3 Gene
protein-coding GIFtS: 41
GCID: GC07M139993
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|
solute carrier family 37 (glycerol-3-phosphate transporter),...
| |
Aliases
for SLC37A3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 37 (Glycerol-3-Phosphate Transporter), Member 31 2 | | Solute Carrier Family 37 Member 32 3 | | DKFZp761N06241 | | Sugar Phosphate Exchanger 32 | | SPX33 |
Export aliases for SLC37A3 gene to outside databasesPrevious GC identifers: GC07M138305 GC07M139363 GC07M139440 GC07M139486 GC07M139680 GC07M134326 |
Summaries
for SLC37A3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SLC37A3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC37A3 gene promoter:
USF1 Elk-1 AML1a POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 Nkx5-1 USF-1 Sox9
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC37A3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC37A3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34SLC37A3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M139993: view genomic region
(about GC identifiers)
Start:
|
139,993,493 bp from pter |
End:
|
140,104,233 bp from pter |
Size:
|
110,741 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 139,362,371-139,427,142 |
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Proteins
for SLC37A3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPX3_HUMAN, Q8NCC5 (See
protein sequence)Recommended Name: Sugar phosphate exchanger 3 Size: 494 amino acids; 54486 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q6PIU7 Q86SS4 Q9BQG7Alternative splicing: 3 isoforms: Q8NCC5-1 Q8NCC5-2 Q8NCC5-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC37A3: NX_Q8NCC5
SLC37A3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_115671.1 NP_996996.1
ENSEMBL proteins: ENSP00000417365 ENSP00000343358 ENSP00000397481 ENSP00000321498 ENSP00000418610 ENSP00000418158 ENSP00000418136 ENSP00000417380 ENSP00000417447 ENSP00000417461 ENSP00000419285 ENSP00000420771 ENSP00000419701 ENSP00000418585 ENSP00000417449 ENSP00000419024 ENSP00000419410 ENSP00000417181 ENSP00000412208
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC37A3 for ontologies About GeneDecksing
SLC37A3 Antibody Products:
Assay Products for SLC37A3: |
Protein
Domains /
Families
for SLC37A3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC37A3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NCC5ProtoNet protein and cluster: Q8NCC5 UniProtKB/Swiss-Prot: SPX3_HUMAN, Q8NCC5Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family |
Function
for SLC37A3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC37A3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC37A3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SLC37A3 (NM_032295) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC37A3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC37A3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC37A3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005215 | transporter activity |
IEA | -- |
SLC37A3 for ontologies About GeneDecksing
|
Pathways & Interactions
for SLC37A3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC37A3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SLC37A3 (ENSP000003214984) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008643 | carbohydrate transport |
IEA | -- | | GO:0055085 | transmembrane transport |
IEA | -- |
SLC37A3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC37A3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC37A3
Search CenterWatch for drugs/clinical trials and news about SLC37A3 / SPX3
|
Transcripts
for SLC37A3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC37A3 gene (2 alternative transcripts): NM_032295.2 NM_207113.1 Unigene Clusters for SLC37A3: Solute carrier family 37 (glycerol-3-phosphate transporter), member 3 Hs.446021 [show with all ESTs], Hs.738791 Unigene Representative Sequences: NM_207113, AK13134718/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29): ENST00000477571 ENST00000340308 ENST00000447932 ENST00000326232(uc003vvo.3 uc003vvp.3 uc010lnh.3)
ENST00000473060 ENST00000469636 ENST00000498469 ENST00000491357 ENST00000485538
ENST00000492027 ENST00000477006 ENST00000460560(uc011kqz.2) ENST00000485734
ENST00000485139 ENST00000487319 ENST00000485861 ENST00000484416 ENST00000490760
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC37A3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC37A3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SLC37A3 (NM_032295) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC37A3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC37A3 |
Additional cDNA sequence: AK131347.1 21 DOTS entries: DT.100848915 DT.444305 DT.101982220 DT.86835754 DT.100860223 DT.75111774 DT.100662588 DT.121036828 DT.315575 DT.102834283 DT.40130699 DT.97858699 DT.121036831 DT.121036858 DT.95176290 DT.102824284 DT.121036839 DT.121036868 DT.121036914 DT.40243162 DT.91742277 24/176 AceView cDNA sequences (see all 176): AI246337 BX463928 NM_207113 AI050092 AI335807 AI343255 BF740621 AA345728 BE794018 BM669953 AA463822 CA454738 AU279849 BU679061 CN480177 NM_032295 CR626251 BQ777595 AW025633 CD722783 Z44787 CB069609 CR614619 BC046567
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLC37A3 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | |
| ExUns: | 16d |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for SLC37A3
|
Expression
for SLC37A3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC37A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTACTTTCTG
About this image
See SLC37A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC37A3
SOURCE GeneReport for Unigene clusters: Hs.446021 Hs.738791
SABiosciences Custom PCR Arrays for SLC37A3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC37A3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC37A3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC37A3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC37A3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC37A3 |
Orthologs
for SLC37A3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SLC37A3 gene from 6/15 species (see all 15) About this table
ENSEMBL Gene Tree for SLC37A3 (if available)
TreeFam Gene Tree for SLC37A3 (if available) |
Paralogs
for SLC37A3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC37A3 gene
- SLC37A12 SLC37A22
2 SIMAP similar genes for SLC37A3 using alignment to 17 protein entries: SPX3_HUMAN (see all proteins):SLC37A2 SLC37A1
SLC37A3 for paralogs About GeneDecksing
|
Genomic Variants
for SLC37A3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC37A3 (139993493 - 140104233 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC37A3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC37A3 |
|
Disorders
/ Diseases
for SLC37A3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC37A3 for disorders About GeneDecksing
1  disease for SLC37A3: About MalaCardsglycogen storage disease
1 disease from the University of Copenhagen DISEASES database for SLC37A3:Glycogen storage disease Export disorders for SLC37A3 gene to outside databases
|
Publications
for SLC37A3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC37A3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC37A3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The human sugar-phosphate/phosphate exchanger family SLC37. (PubMed id 12811562)1 Bartoloni L. and Antonarakis S.E. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
|
External Searches for SLC37A3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC37A3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC37A3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC37A3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC37A3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC37A3 gene:
Search GeneIP for patents involving SLC37A3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC37A3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC37A3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC37A3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC37A3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC37A3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC37A3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC37A3 |
| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC37A3 |
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