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Aliases for SLC37A2 Gene

Aliases for SLC37A2 Gene

  • Solute Carrier Family 37 Member 2 2 3 4 5
  • Solute Carrier Family 37 (Glycerol-3-Phosphate Transporter), Member 2 2 3
  • Solute Carrier Family 37 (Glucose-6-Phosphate Transporter), Member 2 2 3
  • Glucose-6-Phosphate Exchanger SLC37A2 3
  • Sugar Phosphate Exchanger 2 3
  • Pp11662 3

External Ids for SLC37A2 Gene

Previous GeneCards Identifiers for SLC37A2 Gene

  • GC11P126446
  • GC11P124966
  • GC11P124470
  • GC11P124438
  • GC11P124933
  • GC11P120875

Summaries for SLC37A2 Gene

GeneCards Summary for SLC37A2 Gene

SLC37A2 (Solute Carrier Family 37 Member 2) is a Protein Coding gene. Diseases associated with SLC37A2 include Caffey Disease. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLC37A1.

UniProtKB/Swiss-Prot for SLC37A2 Gene

  • Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.

Additional gene information for SLC37A2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC37A2 Gene

Genomics for SLC37A2 Gene

Regulatory Elements for SLC37A2 Gene

Enhancers for SLC37A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H125068 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.2 +9.3 9325 8.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SP5 ZNF592 KAT8 MEF2D SMARCA4 SLC37A2 CCDC15 TMEM218 KRT18P59 ENSG00000255475 ROBO4 HEPACAM LOC105369549 TBRG1 PIR45309
GH11H125123 1.4 Ensembl ENCODE dbSUPER 10.3 +61.1 61134 1.2 FOXA2 PKNOX1 ZBTB40 RAD21 YY1 ZNF766 ZNF143 FOS CREM THAP11 PKNOX2-AS1 PKNOX2 SLC37A2 HEPACAM KRT18P59 ENSG00000255475
GH11H125090 1.2 Ensembl ENCODE dbSUPER 11.4 +28.5 28452 1.4 ELF3 CTCF ZNF654 CEBPB REST ELF1 CEBPG RAD21 FOSL1 CC2D1A SLC37A2 ENSG00000255475 KRT18P59 TMEM218 LOC105369549 GC11P125088
GH11H125110 1.3 ENCODE dbSUPER 10.2 +48.4 48443 2.2 HDGF PKNOX1 ATF1 SIN3A ARID4B DMAP1 YY1 GLIS2 ELK1 ZNF143 ENSG00000255475 PKNOX2-AS1 PKNOX2 SLC37A2 CCDC15 ENSG00000254943 TMEM218 GC11P125088
GH11H125036 0.9 Ensembl ENCODE 11.6 -26.0 -25950 1.3 ZBTB21 JUN ATF2 FOSL1 CTBP1 JUND GATA3 HMBOX1 TRIM24 FOS LOC105369549 CCDC15 SLC37A2 TMEM218 KRT18P59 ENSG00000255475 GC11M125045 GC11M125021
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC37A2 on UCSC Golden Path with GeneCards custom track

Promoters for SLC37A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000046468 333 1601 ARID4B SIN3A ZNF143 ZNF207 ATF7 RUNX3 MXD4 JUNB REST KAT8

Genomic Locations for SLC37A2 Gene

Genomic Locations for SLC37A2 Gene
chr11:125,063,067-125,090,516
(GRCh38/hg38)
Size:
27,450 bases
Orientation:
Plus strand
chr11:124,932,963-124,960,412
(GRCh37/hg19)

Genomic View for SLC37A2 Gene

Genes around SLC37A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC37A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC37A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC37A2 Gene

Proteins for SLC37A2 Gene

  • Protein details for SLC37A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TED4-G6PT3_HUMAN
    Recommended name:
    Glucose-6-phosphate exchanger SLC37A2
    Protein Accession:
    Q8TED4
    Secondary Accessions:
    • A8K2P9
    • Q6P599
    • Q7Z7P8
    • Q8TEM2

    Protein attributes for SLC37A2 Gene

    Size:
    501 amino acids
    Molecular mass:
    54436 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84926.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC37A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC37A2 Gene

Post-translational modifications for SLC37A2 Gene

  • Glycosylation at isoforms=2, 353, Asn62, and isoforms=2, 368
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC37A2 Gene

No data available for DME Specific Peptides for SLC37A2 Gene

Domains & Families for SLC37A2 Gene

Gene Families for SLC37A2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC37A2 Gene

Suggested Antigen Peptide Sequences for SLC37A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TED4

UniProtKB/Swiss-Prot:

G6PT3_HUMAN :
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
Family:
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
genes like me logo Genes that share domains with SLC37A2: view

Function for SLC37A2 Gene

Molecular function for SLC37A2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by vanadate but not by chlorogenic acid.
UniProtKB/Swiss-Prot Function:
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.

Phenotypes From GWAS Catalog for SLC37A2 Gene

Gene Ontology (GO) - Molecular Function for SLC37A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015297 antiporter activity IEA --
GO:0061513 glucose 6-phosphate:inorganic phosphate antiporter activity IDA 21949678
genes like me logo Genes that share ontologies with SLC37A2: view
genes like me logo Genes that share phenotypes with SLC37A2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC37A2 Gene

Localization for SLC37A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC37A2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC37A2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC37A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IDA 21949678
genes like me logo Genes that share ontologies with SLC37A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC37A2 Gene

Pathways & Interactions for SLC37A2 Gene

SuperPathways for SLC37A2 Gene

No Data Available

Interacting Proteins for SLC37A2 Gene

Gene Ontology (GO) - Biological Process for SLC37A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0015760 glucose-6-phosphate transport TAS --
GO:0035435 phosphate ion transmembrane transport IDA 21949678
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC37A2: view

No data available for Pathways by source and SIGNOR curated interactions for SLC37A2 Gene

Drugs & Compounds for SLC37A2 Gene

No Compound Related Data Available

Transcripts for SLC37A2 Gene

Unigene Clusters for SLC37A2 Gene

Solute carrier family 37 (glycerol-3-phosphate transporter), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC37A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1: -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for SLC37A2 Gene

GeneLoc Exon Structure for
SLC37A2
ECgene alternative splicing isoforms for
SLC37A2

Expression for SLC37A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC37A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC37A2 Gene

This gene is overexpressed in Adrenal Gland (x10.2), Skin - Sun Exposed (Lower leg) (x5.9), Minor Salivary Gland (x4.8), and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Protein differential expression in normal tissues from HIPED for SLC37A2 Gene

This gene is overexpressed in Breast (25.0), Monocytes (19.1), Cervix (15.0), and Adrenal (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC37A2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC37A2 Gene:

SLC37A2

SOURCE GeneReport for Unigene cluster for SLC37A2 Gene:

Hs.352661

mRNA Expression by UniProt/SwissProt for SLC37A2 Gene:

Q8TED4-G6PT3_HUMAN
Tissue specificity: Detected in intestine and pancreas. Lower expression is also detected in liver and kidney.

Evidence on tissue expression from TISSUES for SLC37A2 Gene

  • Spleen(4.2)
  • Pancreas(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SLC37A2: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC37A2 Gene

Orthologs for SLC37A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC37A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC37A2 33 34
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia SLC37A2 33 34
  • 87.53 (n)
cow
(Bos Taurus)
Mammalia SLC37A2 33 34
  • 85.28 (n)
rat
(Rattus norvegicus)
Mammalia Slc37a2 33
  • 85.25 (n)
mouse
(Mus musculus)
Mammalia Slc37a2 33 16 34
  • 84.59 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC37A2 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC37A2 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC37A2 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc37a2 33
  • 66.32 (n)
Str.7479 33
zebrafish
(Danio rerio)
Actinopterygii slc37a2 33 34
  • 68.85 (n)
wufv35a12 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006413 33
  • 58.37 (n)
fruit fly
(Drosophila melanogaster)
Insecta MFS16 33 34
  • 57.21 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PS3 33
  • 52.66 (n)
soybean
(Glycine max)
eudicotyledons Gma.3539 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9801 33
rice
(Oryza sativa)
Liliopsida Os04g0555300 33
  • 55.8 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.11166 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9170 34
  • 53 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3087 33
Species where no ortholog for SLC37A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for SLC37A2 Gene

ENSEMBL:
Gene Tree for SLC37A2 (if available)
TreeFam:
Gene Tree for SLC37A2 (if available)

Paralogs for SLC37A2 Gene

Paralogs for SLC37A2 Gene

(2) SIMAP similar genes for SLC37A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC37A2: view

Variants for SLC37A2 Gene

Sequence variations from dbSNP and Humsavar for SLC37A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000043552 -- 125,090,907(+) CTGAA(C/G)GGGAT downstream-variant-500B
rs1000171968 -- 125,072,333(+) AACCT(C/T)CCTAT intron-variant
rs1000241969 -- 125,087,431(+) GCTTT(C/T)TCCAC intron-variant
rs1000253636 -- 125,075,926(+) TGGGG(C/T)TCCAC intron-variant
rs1000284828 -- 125,076,092(+) TTTCC(A/G)TCCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC37A2 Gene

Variant ID Type Subtype PubMed ID
nsv1054682 CNV gain 25217958
nsv520010 CNV loss 19592680
nsv525136 CNV loss 19592680
nsv527157 CNV loss 19592680
nsv952754 CNV deletion 24416366

Variation tolerance for SLC37A2 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.12; 80.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC37A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC37A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC37A2 Gene

Disorders for SLC37A2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC37A2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
caffey disease
  • cortical congenital hyperostosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC37A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC37A2
genes like me logo Genes that share disorders with SLC37A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC37A2 Gene

Publications for SLC37A2 Gene

  1. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. (PMID: 21949678) Pan CJ … Chou JY (PloS one 2011) 3 4 60
  2. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M … Yates JR (Journal of proteome research 2009) 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. The human sugar-phosphate/phosphate exchanger family SLC37. (PMID: 12811562) Bartoloni L … Antonarakis SE (Pflugers Archiv : European journal of physiology 2004) 3 60

Products for SLC37A2 Gene

Sources for SLC37A2 Gene

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