Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC37A2 Gene

Aliases for SLC37A2 Gene

  • Solute Carrier Family 37 (Glucose-6-Phosphate Transporter), Member 2 2 3
  • Solute Carrier Family 37 (Glycerol-3-Phosphate Transporter), Member 2 2 3
  • Solute Carrier Family 37 Member 2 3 4
  • Pp11662 3
  • SPX2 4

External Ids for SLC37A2 Gene

Previous GeneCards Identifiers for SLC37A2 Gene

  • GC11P126446
  • GC11P124966
  • GC11P124470
  • GC11P124438
  • GC11P124933
  • GC11P120875

Summaries for SLC37A2 Gene

GeneCards Summary for SLC37A2 Gene

SLC37A2 (Solute Carrier Family 37 (Glucose-6-Phosphate Transporter), Member 2) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLC37A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC37A2 Gene

Genomics for SLC37A2 Gene

Regulatory Elements for SLC37A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC37A2 Gene

Chromosome:
11
Start:
125,063,067 bp from pter
End:
125,090,516 bp from pter
Size:
27,450 bases
Orientation:
Plus strand

Genomic View for SLC37A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SLC37A2 Gene

Proteins for SLC37A2 Gene

  • Protein details for SLC37A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TED4-SPX2_HUMAN
    Recommended name:
    Sugar phosphate exchanger 2
    Protein Accession:
    Q8TED4
    Secondary Accessions:
    • A8K2P9
    • Q6P599
    • Q7Z7P8
    • Q8TEM2

    Protein attributes for SLC37A2 Gene

    Size:
    501 amino acids
    Molecular mass:
    54436 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84926.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC37A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC37A2 Gene

Proteomics data for SLC37A2 Gene at MOPED

Post-translational modifications for SLC37A2 Gene

  • Glycosylation at Asn 53, Asn 62, and Asn 68
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC37A2 Gene

No data available for DME Specific Peptides for SLC37A2 Gene

Domains & Families for SLC37A2 Gene

Gene Families for SLC37A2 Gene

Protein Domains for SLC37A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC37A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TED4

UniProtKB/Swiss-Prot:

SPX2_HUMAN :
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
Family:
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
genes like me logo Genes that share domains with SLC37A2: view

Function for SLC37A2 Gene

Gene Ontology (GO) - Molecular Function for SLC37A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0015315 organophosphate:inorganic phosphate antiporter activity IBA --
genes like me logo Genes that share ontologies with SLC37A2: view

Phenotypes for SLC37A2 Gene

GenomeRNAi human phenotypes for SLC37A2:
genes like me logo Genes that share phenotypes with SLC37A2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC37A2 Gene

Localization for SLC37A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC37A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC37A2 Gene COMPARTMENTS Subcellular localization image for SLC37A2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC37A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IBA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with SLC37A2: view

Pathways & Interactions for SLC37A2 Gene

SuperPathways for SLC37A2 Gene

No Data Available

Interacting Proteins for SLC37A2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000311833%0d%0a9606.ENSP00000356903%0d%0a9606.ENSP00000386935%0d%0a9606.ENSP00000338703%0d%0a
Selected Interacting proteins: Q8TED4-SPX2_HUMAN ENSP00000311833 for SLC37A2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SLC37A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006820 anion transport IBA --
GO:0008643 carbohydrate transport IEA --
GO:0035435 phosphate ion transmembrane transport IBA --
GO:0055062 phosphate ion homeostasis IBA --
genes like me logo Genes that share ontologies with SLC37A2: view

No data available for Pathways by source and SIGNOR curated interactions for SLC37A2 Gene

Drugs & Compounds for SLC37A2 Gene

No Compound Related Data Available

Transcripts for SLC37A2 Gene

Unigene Clusters for SLC37A2 Gene

Solute carrier family 37 (glycerol-3-phosphate transporter), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC37A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1: -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for SLC37A2 Gene

GeneLoc Exon Structure for
SLC37A2
ECgene alternative splicing isoforms for
SLC37A2

Expression for SLC37A2 Gene

mRNA expression in normal human tissues for SLC37A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC37A2 Gene

This gene is overexpressed in Adrenal Gland (x10.2), Skin - Sun Exposed (Lower leg) (x5.9), Minor Salivary Gland (x4.8), and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Protein differential expression in normal tissues from HIPED for SLC37A2 Gene

This gene is overexpressed in Breast (25.0), Monocytes (19.1), Cervix (15.0), and Adrenal (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC37A2 Gene



SOURCE GeneReport for Unigene cluster for SLC37A2 Gene Hs.352661

genes like me logo Genes that share expression patterns with SLC37A2: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC37A2 Gene

Orthologs for SLC37A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC37A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC37A2 35
  • 85.28 (n)
  • 84.39 (a)
SLC37A2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC37A2 35
  • 87.53 (n)
  • 86.49 (a)
SLC37A2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc37a2 35
  • 84.59 (n)
  • 87.7 (a)
Slc37a2 16
Slc37a2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC37A2 35
  • 99.6 (n)
  • 99.41 (a)
SLC37A2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc37a2 35
  • 85.25 (n)
  • 87.3 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC37A2 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC37A2 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC37A2 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc37a2 35
  • 66.32 (n)
  • 70.77 (a)
Str.7479 35
zebrafish
(Danio rerio)
Actinopterygii slc37a2 35
  • 68.85 (n)
  • 72.34 (a)
wufv35a12 35
slc37a2 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006413 35
  • 58.37 (n)
  • 54.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta MFS16 35
  • 57.21 (n)
  • 55.44 (a)
MFS16 36
  • 45 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PS3 35
  • 52.66 (n)
  • 50.86 (a)
soybean
(Glycine max)
eudicotyledons Gma.3539 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9801 35
rice
(Oryza sativa)
Liliopsida Os04g0555300 35
  • 55.8 (n)
  • 52.46 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.11166 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3087 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9170 36
  • 53 (a)
OneToMany
Species with no ortholog for SLC37A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for SLC37A2 Gene

ENSEMBL:
Gene Tree for SLC37A2 (if available)
TreeFam:
Gene Tree for SLC37A2 (if available)

Paralogs for SLC37A2 Gene

Paralogs for SLC37A2 Gene

(2) SIMAP similar genes for SLC37A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC37A2: view

Variants for SLC37A2 Gene

Sequence variations from dbSNP and Humsavar for SLC37A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs948268 -- 125,085,136(-) ACCAG(A/G)TCAGC synonymous-codon, reference, utr-variant-3-prime
rs948269 -- 125,084,473(-) TGACC(C/G/T)TCGCT intron-variant
rs948270 -- 125,084,386(-) GCACA(C/T)AGGCC intron-variant
rs1142924 -- 125,090,388(+) ccaat(A/C)agcag utr-variant-3-prime
rs3802807 -- 125,085,503(+) GGCCG(A/G)CCCCT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC37A2 Gene

Variant ID Type Subtype PubMed ID
nsv520010 CNV Loss 19592680
nsv525136 CNV Loss 19592680
nsv527157 CNV Loss 19592680

Variation tolerance for SLC37A2 Gene

Residual Variation Intolerance Score: 50.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.12; 80.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC37A2 Gene

HapMap Linkage Disequilibrium report
SLC37A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC37A2 Gene

Disorders for SLC37A2 Gene

Relevant External Links for SLC37A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC37A2
genes like me logo Genes that share disorders with SLC37A2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC37A2 Gene

Publications for SLC37A2 Gene

  1. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. (PMID: 21949678) Pan C.J. … Chou J.Y. (PLoS ONE 2011) 67
  2. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. The human sugar-phosphate/phosphate exchanger family SLC37. (PMID: 12811562) Bartoloni L. … Antonarakis S.E. (Pflugers Arch. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for SLC37A2 Gene

Sources for SLC37A2 Gene

Back to Top

Content