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Aliases for SLC37A2 Gene

Aliases for SLC37A2 Gene

  • Solute Carrier Family 37 (Glucose-6-Phosphate Transporter), Member 2 2 3
  • Solute Carrier Family 37 (Glycerol-3-Phosphate Transporter), Member 2 2 3
  • Solute Carrier Family 37 Member 2 3 4
  • Sugar Phosphate Exchanger 2 3
  • Pp11662 3
  • SPX2 4

External Ids for SLC37A2 Gene

Previous GeneCards Identifiers for SLC37A2 Gene

  • GC11P126446
  • GC11P124966
  • GC11P124470
  • GC11P124438
  • GC11P124933
  • GC11P120875

Summaries for SLC37A2 Gene

GeneCards Summary for SLC37A2 Gene

SLC37A2 (Solute Carrier Family 37 (Glucose-6-Phosphate Transporter), Member 2) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLC37A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC37A2 Gene

Genomics for SLC37A2 Gene

Regulatory Elements for SLC37A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC37A2 Gene

Start:
125,063,067 bp from pter
End:
125,090,516 bp from pter
Size:
27,450 bases
Orientation:
Plus strand

Genomic View for SLC37A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC37A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC37A2 Gene

Proteins for SLC37A2 Gene

  • Protein details for SLC37A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TED4-SPX2_HUMAN
    Recommended name:
    Sugar phosphate exchanger 2
    Protein Accession:
    Q8TED4
    Secondary Accessions:
    • A8K2P9
    • Q6P599
    • Q7Z7P8
    • Q8TEM2

    Protein attributes for SLC37A2 Gene

    Size:
    501 amino acids
    Molecular mass:
    54436 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84926.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC37A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC37A2 Gene

Proteomics data for SLC37A2 Gene at MOPED

Post-translational modifications for SLC37A2 Gene

  • Glycosylation at Asn53, Asn62, and Asn68
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC37A2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC37A2

No data available for DME Specific Peptides for SLC37A2 Gene

Domains for SLC37A2 Gene

Gene Families for SLC37A2 Gene

Protein Domains for SLC37A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC37A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TED4

UniProtKB/Swiss-Prot:

SPX2_HUMAN :
  • Q8TED4
Family:
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
genes like me logo Genes that share domains with SLC37A2: view

Function for SLC37A2 Gene

Gene Ontology (GO) - Molecular Function for SLC37A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
genes like me logo Genes that share ontologies with SLC37A2: view

Animal Model Products

CRISPR Products

miRNA for SLC37A2 Gene

miRTarBase miRNAs that target SLC37A2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC37A2 Gene

Localization for SLC37A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC37A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC37A2 Gene COMPARTMENTS Subcellular localization image for SLC37A2 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC37A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with SLC37A2: view

Pathways for SLC37A2 Gene

SuperPathways for SLC37A2 Gene

No Data Available

Interacting Proteins for SLC37A2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000311833%0d%0a9606.ENSP00000356903%0d%0a9606.ENSP00000386935%0d%0a9606.ENSP00000338703%0d%0a
Selected Interacting proteins: ENSP00000311833 Q8TED4-SPX2_HUMAN for SLC37A2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC37A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC37A2: view

No data available for Pathways by source for SLC37A2 Gene

Transcripts for SLC37A2 Gene

Unigene Clusters for SLC37A2 Gene

Solute carrier family 37 (glycerol-3-phosphate transporter), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC37A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC37A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1: -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for SLC37A2 Gene

GeneLoc Exon Structure for
SLC37A2
ECgene alternative splicing isoforms for
SLC37A2

Expression for SLC37A2 Gene

mRNA expression in normal human tissues for SLC37A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC37A2 Gene

This gene is overexpressed in Adrenal Gland (10.2), Skin - Sun Exposed (Lower leg) (5.9), Minor Salivary Gland (4.8), and Skin - Not Sun Exposed (Suprapubic) (4.5).

Protein differential expression in normal tissues for SLC37A2 Gene

This gene is overexpressed in Breast (25.0), Monocytes (19.1), Cervix (15.0), and Adrenal (9.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC37A2 Gene

SOURCE GeneReport for Unigene cluster for SLC37A2 Gene Hs.352661

genes like me logo Genes that share expressions with SLC37A2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for SLC37A2 Gene

Orthologs for SLC37A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC37A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC37A2 35
  • 85.28 (n)
  • 84.39 (a)
SLC37A2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC37A2 35
  • 87.53 (n)
  • 86.49 (a)
SLC37A2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc37a2 35
  • 84.59 (n)
  • 87.7 (a)
Slc37a2 16
Slc37a2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC37A2 35
  • 99.6 (n)
  • 99.41 (a)
SLC37A2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc37a2 35
  • 85.25 (n)
  • 87.3 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC37A2 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC37A2 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC37A2 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc37a2 35
  • 66.32 (n)
  • 70.77 (a)
Str.7479 35
zebrafish
(Danio rerio)
Actinopterygii slc37a2 35
  • 68.85 (n)
  • 72.34 (a)
wufv35a12 35
slc37a2 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006413 35
  • 58.37 (n)
  • 54.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta MFS16 35
  • 57.21 (n)
  • 55.44 (a)
MFS16 36
  • 45 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PS3 35
  • 52.66 (n)
  • 50.86 (a)
soybean
(Glycine max)
eudicotyledons Gma.3539 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9801 35
rice
(Oryza sativa)
Liliopsida Os04g0555300 35
  • 55.8 (n)
  • 52.46 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.11166 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3087 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9170 36
  • 53 (a)
OneToMany
Species with no ortholog for SLC37A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for SLC37A2 Gene

ENSEMBL:
Gene Tree for SLC37A2 (if available)
TreeFam:
Gene Tree for SLC37A2 (if available)

Paralogs for SLC37A2 Gene

Paralogs for SLC37A2 Gene

Selected SIMAP similar genes for SLC37A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC37A2: view

Variants for SLC37A2 Gene

Sequence variations from dbSNP and Humsavar for SLC37A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs948268 -- 125,085,136(-) ACCAG(A/G)TCAGC synonymous-codon, reference, nc-transcript-variant
rs948269 -- 125,084,473(-) TGACC(C/G)TCGCT intron-variant
rs948270 -- 125,084,386(-) GCACA(C/T)AGGCC intron-variant
rs1142924 -- 125,090,388(+) ccaat(A/C)agcag utr-variant-3-prime
rs3802807 -- 125,085,503(+) GGCCG(A/G)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC37A2 Gene

Variant ID Type Subtype PubMed ID
nsv520010 CNV Loss 19592680
nsv525136 CNV Loss 19592680
nsv527157 CNV Loss 19592680

Relevant External Links for SLC37A2 Gene

HapMap Linkage Disequilibrium report
SLC37A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC37A2 Gene

Disorders for SLC37A2 Gene

(1) University of Copenhagen DISEASES for SLC37A2 Gene

genes like me logo Genes that share disorders with SLC37A2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for SLC37A2 Gene

Publications for SLC37A2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. The human sugar-phosphate/phosphate exchanger family SLC37. (PMID: 12811562) Bartoloni L. … Antonarakis S.E. (Pflugers Arch. 2004) 3
  3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3
  4. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. (PMID: 21949678) Pan C.J. … Chou J.Y. (PLoS ONE 2011) 3
  5. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H. … Ohara O. (DNA Res. 2003) 4

Products for SLC37A2 Gene

Sources for SLC37A2 Gene

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