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Aliases for SLC37A1 Gene

Aliases for SLC37A1 Gene

  • Solute Carrier Family 37 Member 1 2 3 4 5
  • Solute Carrier Family 37 (Glycerol-3-Phosphate Transporter), Member 1 2 3
  • Solute Carrier Family 37 (Glucose-6-Phosphate Transporter), Member 1 2 3
  • Glycerol-3-Phosphate Permease 3 4
  • G-3-P Permease 3 4
  • G3PP 3 4
  • Glucose-6-Phosphate Exchanger SLC37A1 3
  • Glycerol-3-Phosphate Transporter 3
  • G-3-P Transporter 3

External Ids for SLC37A1 Gene

Previous GeneCards Identifiers for SLC37A1 Gene

  • GC21P040467
  • GC21P042814
  • GC21P042828
  • GC21P042807
  • GC21P043918
  • GC21P029337

Summaries for SLC37A1 Gene

Entrez Gene Summary for SLC37A1 Gene

  • The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SLC37A1 Gene

SLC37A1 (Solute Carrier Family 37 Member 1) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLC37A2.

UniProtKB/Swiss-Prot for SLC37A1 Gene

  • Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC37A1 Gene

Genomics for SLC37A1 Gene

Regulatory Elements for SLC37A1 Gene

Enhancers for SLC37A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G042512 1.6 Ensembl ENCODE dbSUPER 41.4 +20.1 20109 6.7 HDGF PKNOX1 ARNT SIN3A ARID4B DMAP1 ZNF2 CBX5 ZNF143 ZNF207 SLC37A1 PRDM15 WDR4 ENSG00000235772 RSPH1 TFF2 ENSG00000227698 U2AF1 ENSG00000231867
GH21G042522 1.5 Ensembl ENCODE dbSUPER 43.6 +30.0 30011 6.5 HDGF ATF1 PKNOX1 WRNIP1 FEZF1 ZNF48 YY1 TCF12 JUNB REST SLC37A1 ENSG00000235772 RSPH1 LOC101930094 TFF2 ENSG00000231867
GH21G042531 1.8 FANTOM5 Ensembl ENCODE dbSUPER 33.6 +38.2 38245 5.0 HDGF PKNOX1 ATF1 ZFP64 SIN3A JUNB REST TBX21 CBX8 SMARCA4 SLC37A1 ENSG00000235772 RSPH1 LOC101928284 TFF2 ABCG1 PKNOX1 ENSG00000231867
GH21G042457 2 FANTOM5 Ensembl ENCODE dbSUPER 19.7 -34.1 -34113 8.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A YY1 ZNF766 ZNF207 FOS PRDM15 WDR4 SLC37A1 RSPH1 LOC101930094 ABCG1 U2AF1 TFF2 ENSG00000235772 ZBTB21
GH21G042490 1.3 ENCODE dbSUPER 29 -2.2 -2150 7.4 HDGF PKNOX1 AGO1 SIN3A ARID4B DMAP1 YY1 CBX5 ZNF143 FOS SLC37A1 ENSG00000235772 WDR4 RSPH1 PRDM15 RNU6-1149P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC37A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLC37A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000142740 392 1201 HDGF PKNOX1 ATF1 AGO1 ARID4B SIN3A YY1 ELK1 ZNF143 FOS

Genomic Location for SLC37A1 Gene

Chromosome:
21
Start:
42,496,008 bp from pter
End:
42,581,440 bp from pter
Size:
85,433 bases
Orientation:
Plus strand

Genomic View for SLC37A1 Gene

Genes around SLC37A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC37A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC37A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC37A1 Gene

Proteins for SLC37A1 Gene

  • Protein details for SLC37A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57057-G6PT2_HUMAN
    Recommended name:
    Glucose-6-phosphate exchanger SLC37A1
    Protein Accession:
    P57057
    Secondary Accessions:
    • D3DSJ7
    • Q9HAQ1

    Protein attributes for SLC37A1 Gene

    Size:
    533 amino acids
    Molecular mass:
    57648 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC37A1 Gene

Post-translational modifications for SLC37A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC37A1 Gene

Domains & Families for SLC37A1 Gene

Gene Families for SLC37A1 Gene

Protein Domains for SLC37A1 Gene

Suggested Antigen Peptide Sequences for SLC37A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57057

UniProtKB/Swiss-Prot:

G6PT2_HUMAN :
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
Family:
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
genes like me logo Genes that share domains with SLC37A1: view

Function for SLC37A1 Gene

Molecular function for SLC37A1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by vanadate but not by chlorogenic acid.
UniProtKB/Swiss-Prot Function:
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.

Gene Ontology (GO) - Molecular Function for SLC37A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015297 antiporter activity IEA --
GO:0061513 glucose 6-phosphate:inorganic phosphate antiporter activity IDA 21949678
genes like me logo Genes that share ontologies with SLC37A1: view
genes like me logo Genes that share phenotypes with SLC37A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC37A1

CRISPR Products

miRNA for SLC37A1 Gene

miRTarBase miRNAs that target SLC37A1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC37A1 Gene

Localization for SLC37A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC37A1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC37A1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SLC37A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IDA 21949678
genes like me logo Genes that share ontologies with SLC37A1: view

Pathways & Interactions for SLC37A1 Gene

SuperPathways for SLC37A1 Gene

No Data Available

Interacting Proteins for SLC37A1 Gene

Gene Ontology (GO) - Biological Process for SLC37A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0015760 glucose-6-phosphate transport IDA,TAS --
GO:0035435 phosphate ion transmembrane transport IDA 21949678
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC37A1: view

No data available for Pathways by source and SIGNOR curated interactions for SLC37A1 Gene

Drugs & Compounds for SLC37A1 Gene

(1) Additional Compounds for SLC37A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC37A1: view

Transcripts for SLC37A1 Gene

Unigene Clusters for SLC37A1 Gene

Solute carrier family 37 (glycerol-3-phosphate transporter), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC37A1 Gene

No ASD Table

Relevant External Links for SLC37A1 Gene

GeneLoc Exon Structure for
SLC37A1
ECgene alternative splicing isoforms for
SLC37A1

Expression for SLC37A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC37A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC37A1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC37A1 Gene



Protein tissue co-expression partners for SLC37A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC37A1 Gene:

SLC37A1

SOURCE GeneReport for Unigene cluster for SLC37A1 Gene:

Hs.547009

mRNA Expression by UniProt/SwissProt for SLC37A1 Gene:

P57057-G6PT2_HUMAN
Tissue specificity: Expressed in numerous tissues, with highest expression in pancreas, kidney, bone marrow, spleen, liver, small intestine, as well as in fetal brain, liver and spleen.

Evidence on tissue expression from TISSUES for SLC37A1 Gene

  • Gall bladder(2)
genes like me logo Genes that share expression patterns with SLC37A1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC37A1 Gene

Orthologs for SLC37A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC37A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC37A1 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia SLC37A1 34 35
  • 86.38 (n)
cow
(Bos Taurus)
Mammalia SLC37A1 34 35
  • 84.74 (n)
mouse
(Mus musculus)
Mammalia Slc37a1 34 16 35
  • 83.24 (n)
rat
(Rattus norvegicus)
Mammalia Slc37a1 34
  • 83.05 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC37A1 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC37A1 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC37A1 34 35
  • 70.15 (n)
lizard
(Anolis carolinensis)
Reptilia SLC37A1 35
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc37a1 34 35
  • 65.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10069 36
  • 44 (a)
MFS16 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T10C6.6b 36
  • 31 (a)
T10C6.6a 36
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17550 34
  • 50.43 (n)
rice
(Oryza sativa)
Liliopsida Os02g0652800 34
  • 54.88 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.12156 34
corn
(Zea mays)
Liliopsida Zm.13067 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9170 35
  • 50 (a)
OneToMany
Species where no ortholog for SLC37A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC37A1 Gene

ENSEMBL:
Gene Tree for SLC37A1 (if available)
TreeFam:
Gene Tree for SLC37A1 (if available)

Paralogs for SLC37A1 Gene

Paralogs for SLC37A1 Gene

(2) SIMAP similar genes for SLC37A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC37A1: view

Variants for SLC37A1 Gene

Sequence variations from dbSNP and Humsavar for SLC37A1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000018467 -- 42,529,975(+) AAAAG(C/G)ACCTT intron-variant, nc-transcript-variant
rs1000023546 -- 42,570,332(+) TGGCT(A/G)TTGCT intron-variant, utr-variant-5-prime
rs1000074876 -- 42,543,943(+) AGCCT(C/G)AATTG intron-variant
rs1000098294 -- 42,513,134(+) GGGGT(A/C)CACTG intron-variant, upstream-variant-2KB
rs1000164827 -- 42,506,639(+) ACTTT(C/T)CCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC37A1 Gene

Variant ID Type Subtype PubMed ID
dgv7861n54 CNV loss 21841781
dgv7862n54 CNV gain+loss 21841781
dgv7863n54 CNV gain+loss 21841781
dgv7864n54 CNV gain 21841781
esv2153018 CNV deletion 18987734
esv25213 CNV loss 19812545
esv2723551 CNV deletion 23290073
esv2723552 CNV deletion 23290073
esv2723553 CNV deletion 23290073
esv2723554 CNV deletion 23290073
esv2723555 CNV deletion 23290073
esv2723556 CNV deletion 23290073
esv2723557 CNV deletion 23290073
esv2723558 CNV deletion 23290073
esv2723559 CNV deletion 23290073
esv2723560 CNV deletion 23290073
esv3400425 CNV insertion 20981092
esv3557769 CNV deletion 23714750
esv3647082 CNV loss 21293372
esv4794 CNV loss 18987735
nsv1139030 CNV deletion 24896259
nsv187256 CNV deletion 16902084
nsv3533 CNV deletion 18451855
nsv521904 CNV loss 19592680
nsv522001 CNV gain 19592680
nsv587633 CNV gain 21841781
nsv587634 CNV gain 21841781
nsv587636 CNV gain 21841781
nsv587647 CNV loss 21841781
nsv587648 CNV loss 21841781
nsv834103 CNV gain 17160897
nsv953633 CNV deletion 24416366

Variation tolerance for SLC37A1 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC37A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC37A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC37A1 Gene

Disorders for SLC37A1 Gene

Relevant External Links for SLC37A1

Genetic Association Database (GAD)
SLC37A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC37A1

No disorders were found for SLC37A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC37A1 Gene

Publications for SLC37A1 Gene

  1. Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency. (PMID: 11112347) Bartoloni L. … Antonarakis S.E. (Genomics 2000) 2 3 4 22 64
  2. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. (PMID: 21949678) Pan C.J. … Chou J.Y. (PLoS ONE 2011) 3 4 64
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4 64
  4. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3 64
  5. Simulation of spontaneous substrate binding revealing the binding pathway and mechanism and initial conformational response of GlpT. (PMID: 20058936) Enkavi G. … Tajkhorshid E. (Biochemistry 2010) 22 64

Products for SLC37A1 Gene

Sources for SLC37A1 Gene

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