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Aliases for SLC37A1 Gene

Aliases for SLC37A1 Gene

  • Solute Carrier Family 37 Member 1 2 3 4
  • Solute Carrier Family 37 (Glucose-6-Phosphate Transporter), Member 1 2 3 5
  • Solute Carrier Family 37 (Glycerol-3-Phosphate Transporter), Member 1 2 3
  • Glycerol-3-Phosphate Permease 3 4
  • G-3-P Transporter 3 4
  • G-3-P Permease 3 4
  • G3PP 3 4

External Ids for SLC37A1 Gene

Previous GeneCards Identifiers for SLC37A1 Gene

  • GC21P040467
  • GC21P042814
  • GC21P042828
  • GC21P042807
  • GC21P043918
  • GC21P029337

Summaries for SLC37A1 Gene

Entrez Gene Summary for SLC37A1 Gene

  • The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SLC37A1 Gene

SLC37A1 (Solute Carrier Family 37 Member 1) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLC37A2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC37A1 Gene

Genomics for SLC37A1 Gene

Regulatory Elements for SLC37A1 Gene

Enhancers for SLC37A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC37A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLC37A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC37A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC37A1 Gene

Chromosome:
21
Start:
42,496,008 bp from pter
End:
42,581,440 bp from pter
Size:
85,433 bases
Orientation:
Plus strand

Genomic View for SLC37A1 Gene

Genes around SLC37A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC37A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC37A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC37A1 Gene

Proteins for SLC37A1 Gene

  • Protein details for SLC37A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57057-GLPT_HUMAN
    Recommended name:
    Glycerol-3-phosphate transporter
    Protein Accession:
    P57057
    Secondary Accessions:
    • D3DSJ7
    • Q9HAQ1

    Protein attributes for SLC37A1 Gene

    Size:
    533 amino acids
    Molecular mass:
    57648 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC37A1 Gene

Proteomics data for SLC37A1 Gene at MOPED

Post-translational modifications for SLC37A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC37A1 Gene

Antibody Products

No data available for DME Specific Peptides for SLC37A1 Gene

Domains & Families for SLC37A1 Gene

Gene Families for SLC37A1 Gene

Protein Domains for SLC37A1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC37A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57057

UniProtKB/Swiss-Prot:

GLPT_HUMAN :
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
Family:
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
genes like me logo Genes that share domains with SLC37A1: view

Function for SLC37A1 Gene

genes like me logo Genes that share phenotypes with SLC37A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC37A1

CRISPR Products

miRNA for SLC37A1 Gene

miRTarBase miRNAs that target SLC37A1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC37A1 Gene

Localization for SLC37A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC37A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC37A1 Gene COMPARTMENTS Subcellular localization image for SLC37A1 gene
Compartment Confidence
plasma membrane 3
cytosol 2
endoplasmic reticulum 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for SLC37A1 Gene

Pathways & Interactions for SLC37A1 Gene

SuperPathways for SLC37A1 Gene

No Data Available

Interacting Proteins for SLC37A1 Gene

Gene Ontology (GO) - Biological Process for SLC37A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
GO:0015760 glucose-6-phosphate transport IDA 21949678
genes like me logo Genes that share ontologies with SLC37A1: view

No data available for Pathways by source and SIGNOR curated interactions for SLC37A1 Gene

Drugs & Compounds for SLC37A1 Gene

(1) Additional Compounds for SLC37A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC37A1: view

Transcripts for SLC37A1 Gene

Unigene Clusters for SLC37A1 Gene

Solute carrier family 37 (glycerol-3-phosphate transporter), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC37A1 Gene

No ASD Table

Relevant External Links for SLC37A1 Gene

GeneLoc Exon Structure for
SLC37A1
ECgene alternative splicing isoforms for
SLC37A1

Expression for SLC37A1 Gene

mRNA expression in normal human tissues for SLC37A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC37A1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC37A1 Gene



SOURCE GeneReport for Unigene cluster for SLC37A1 Gene Hs.547009

mRNA Expression by UniProt/SwissProt for SLC37A1 Gene

P57057-GLPT_HUMAN
Tissue specificity: Expressed in numerous tissues, with highest expression in kidney, bone marrow, spleen, liver, small intestine, as well as in fetal brain, liver and spleen.
genes like me logo Genes that share expression patterns with SLC37A1: view

Protein tissue co-expression partners for SLC37A1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC37A1 Gene

Orthologs for SLC37A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC37A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC37A1 35
  • 84.74 (n)
  • 87.24 (a)
SLC37A1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC37A1 35
  • 86.38 (n)
  • 88.7 (a)
SLC37A1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc37a1 35
  • 83.24 (n)
  • 87.01 (a)
Slc37a1 16
Slc37a1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC37A1 35
  • 99.44 (n)
  • 99.44 (a)
SLC37A1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc37a1 35
  • 83.05 (n)
  • 86.87 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC37A1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC37A1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC37A1 35
  • 70.15 (n)
  • 75.9 (a)
SLC37A1 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC37A1 36
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc37a1 35
  • 65.33 (n)
  • 68.97 (a)
slc37a1 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10069 37
  • 44 (a)
MFS16 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T10C6.6a 37
  • 30 (a)
T10C6.6b 37
  • 31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17550 35
  • 50.43 (n)
  • 45.19 (a)
rice
(Oryza sativa)
Liliopsida Os02g0652800 35
  • 54.88 (n)
  • 49.89 (a)
corn
(Zea mays)
Liliopsida Zm.13067 35
barley
(Hordeum vulgare)
Liliopsida Hv.12156 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9170 36
  • 50 (a)
OneToMany
Species with no ortholog for SLC37A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC37A1 Gene

ENSEMBL:
Gene Tree for SLC37A1 (if available)
TreeFam:
Gene Tree for SLC37A1 (if available)

Paralogs for SLC37A1 Gene

Paralogs for SLC37A1 Gene

(2) SIMAP similar genes for SLC37A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC37A1: view

Variants for SLC37A1 Gene

Sequence variations from dbSNP and Humsavar for SLC37A1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_017110 -
rs228104 - 42,565,845(-) GCTGA(C/T)GGTGG reference, missense
rs365443 -- 42,578,186(+) ACAAC(A/G)CACAC intron-variant, utr-variant-3-prime
rs1399921 -- 42,557,803(+) ATTAA(A/G)CTACA intron-variant
rs1399922 -- 42,557,880(+) AGGTC(C/T)GAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC37A1 Gene

Variant ID Type Subtype PubMed ID
nsv522001 CNV Gain 19592680
nsv834103 CNV Gain 17160897
nsv521904 CNV Loss 19592680
nsv913795 CNV Loss 21882294
esv25213 CNV Loss 19812545
esv2723551 CNV Deletion 23290073
nsv913796 CNV Loss 21882294
dgv4750n71 CNV Loss 21882294
dgv4751n71 CNV Loss 21882294
nsv3533 CNV Loss 18451855
nsv913802 CNV Loss 21882294
esv2723552 CNV Deletion 23290073
esv2153018 CNV Deletion 18987734
esv2723553 CNV Deletion 23290073
esv2723554 CNV Deletion 23290073
esv2723555 CNV Deletion 23290073
esv2723556 CNV Deletion 23290073
esv4794 CNV Deletion 18987735
esv2723557 CNV Deletion 23290073
nsv187256 CNV Loss 16902084
esv2723558 CNV Deletion 23290073
esv2723559 CNV Deletion 23290073
esv2723560 CNV Deletion 23290073

Variation tolerance for SLC37A1 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC37A1 Gene

HapMap Linkage Disequilibrium report
SLC37A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC37A1 Gene

Disorders for SLC37A1 Gene

Relevant External Links for SLC37A1

Genetic Association Database (GAD)
SLC37A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC37A1

No disorders were found for SLC37A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC37A1 Gene

Publications for SLC37A1 Gene

  1. Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency. (PMID: 11112347) Bartoloni L. … Antonarakis S.E. (Genomics 2000) 2 3 4 23 67
  2. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. (PMID: 21949678) Pan C.J. … Chou J.Y. (PLoS ONE 2011) 3
  3. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3
  4. Simulation of spontaneous substrate binding revealing the binding pathway and mechanism and initial conformational response of GlpT. (PMID: 20058936) Enkavi G. … Tajkhorshid E. (Biochemistry 2010) 23
  5. Homology modeling of GLUT4, an insulin regulated facilitated glucose transporter and docking studies with ATP and its inhibitors. (PMID: 19108584) Mohan S S. … Anilkumar G. (J. Biomol. Struct. Dyn. 2009) 23

Products for SLC37A1 Gene

Sources for SLC37A1 Gene

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