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Aliases for SLC36A4 Gene

Aliases for SLC36A4 Gene

  • Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 4 2 3
  • PAT4 3 4 6
  • Proton-Coupled Amino Acid Transporter 4 3
  • Solute Carrier Family 36 Member 4 4
  • Proton/Amino Acid Transporter 4 4

External Ids for SLC36A4 Gene

Previous GeneCards Identifiers for SLC36A4 Gene

  • GC11M092569
  • GC11M092520
  • GC11M092880
  • GC11M088965

Summaries for SLC36A4 Gene

Entrez Gene Summary for SLC36A4 Gene

  • SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members (e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane domains. Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a high-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011 [PubMed 21097500]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SLC36A4 Gene

SLC36A4 (Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 4) is a Protein Coding gene. GO annotations related to this gene include symporter activity. An important paralog of this gene is SLC36A1.

UniProtKB/Swiss-Prot for SLC36A4 Gene

  • Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC36A4 Gene

Genomics for SLC36A4 Gene

Regulatory Elements for SLC36A4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC36A4 Gene

Start:
93,144,171 bp from pter
End:
93,197,975 bp from pter
Size:
53,805 bases
Orientation:
Minus strand

Genomic View for SLC36A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC36A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC36A4 Gene

Proteins for SLC36A4 Gene

  • Protein details for SLC36A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6YBV0-S36A4_HUMAN
    Recommended name:
    Proton-coupled amino acid transporter 4
    Protein Accession:
    Q6YBV0
    Secondary Accessions:
    • Q86X30
    • Q8IVM5
    • Q8N8S6

    Protein attributes for SLC36A4 Gene

    Size:
    504 amino acids
    Molecular mass:
    56157 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAC82496.1; Type=Frameshift; Positions=358, 361, 363, 366, 370, 373, 376, 387, 396, 458, 487; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC36A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC36A4 Gene

Proteomics data for SLC36A4 Gene at MOPED

Post-translational modifications for SLC36A4 Gene

  • Glycosylation at Asn194, Asn197, and Asn495
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC36A4 Gene

No data available for DME Specific Peptides for SLC36A4 Gene

Domains for SLC36A4 Gene

Gene Families for SLC36A4 Gene

Protein Domains for SLC36A4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC36A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6YBV0

UniProtKB/Swiss-Prot:

S36A4_HUMAN :
  • Q6YBV0
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC36A4: view

Function for SLC36A4 Gene

Molecular function for SLC36A4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=3.1 uM for L-proline {ECO:0000269 PubMed:21097500}; KM=1.7 uM for L-tryptophan {ECO:0000269 PubMed:21097500}; pH dependence: Optimum pH is 7.4 (for proline transport). {ECO:0000269 PubMed:21097500};
UniProtKB/Swiss-Prot Function: Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine.

Gene Ontology (GO) - Molecular Function for SLC36A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC36A4: view

Phenotypes for SLC36A4 Gene

genes like me logo Genes that share phenotypes with SLC36A4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC36A4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC36A4 Gene

Localization for SLC36A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC36A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC36A4 Gene COMPARTMENTS Subcellular localization image for SLC36A4 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC36A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005774 vacuolar membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC36A4: view

Pathways for SLC36A4 Gene

SuperPathways for SLC36A4 Gene

No Data Available

Interacting Proteins for SLC36A4 Gene

Gene Ontology (GO) - Biological Process for SLC36A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0015808 L-alanine transport IDA 21097500
GO:0015824 proline transport IDA 21097500
GO:0015827 tryptophan transport IDA 21097500
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SLC36A4: view

No data available for Pathways by source for SLC36A4 Gene

Transcripts for SLC36A4 Gene

Unigene Clusters for SLC36A4 Gene

Solute carrier family 36 (proton/amino acid symporter), member 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC36A4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC36A4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for SLC36A4 Gene

GeneLoc Exon Structure for
SLC36A4
ECgene alternative splicing isoforms for
SLC36A4

Expression for SLC36A4 Gene

mRNA expression in normal human tissues for SLC36A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC36A4 Gene

SOURCE GeneReport for Unigene cluster for SLC36A4 Gene Hs.148766

genes like me logo Genes that share expressions with SLC36A4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC36A4 Gene

Orthologs for SLC36A4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC36A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC36A4 35
  • 99.74 (n)
  • 99.8 (a)
SLC36A4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC36A4 35
  • 91.65 (n)
  • 92.61 (a)
SLC36A4 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC36A4 35
  • 92.31 (n)
  • 93.84 (a)
SLC36A4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc36a4 35
  • 83.67 (n)
  • 89.96 (a)
Slc36a4 16
Slc36a4 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC36A4 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC36A4 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc36a4 35
  • 81.97 (n)
  • 88.11 (a)
chicken
(Gallus gallus)
Aves SLC36A4 35
  • 72.81 (n)
  • 73.98 (a)
SLC36A4 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC36A4 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32457 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc36a4 35
  • 66.95 (n)
  • 65.96 (a)
zebrafish
(Danio rerio)
Actinopterygii slc36a4 35
  • 59.32 (n)
  • 60.13 (a)
slc36a4 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008490 35
  • 48.66 (n)
  • 42.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1139 36
  • 30 (a)
ManyToMany
CG12943 36
  • 24 (a)
ManyToMany
CG13384 35
  • 51.06 (n)
  • 42.55 (a)
CG13384 36
  • 36 (a)
ManyToMany
CG16700 36
  • 32 (a)
ManyToMany
CG32079 36
  • 25 (a)
ManyToMany
CG32081 36
  • 27 (a)
ManyToMany
CG43693 36
  • 28 (a)
ManyToMany
CG4991 36
  • 27 (a)
ManyToMany
CG7888 36
  • 32 (a)
ManyToMany
CG8785 36
  • 31 (a)
ManyToMany
path 36
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C44B7.6 36
  • 26 (a)
ManyToMany
F59B2.2 36
  • 24 (a)
ManyToMany
H32K16.1 36
  • 27 (a)
ManyToMany
T27A1.5 36
  • 32 (a)
ManyToMany
Y38H6C.17 36
  • 25 (a)
ManyToMany
Y43F4B.7 36
  • 30 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER380C 35
  • 45.45 (n)
  • 31.57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT3 36
  • 15 (a)
ManyToMany
AVT4 35
  • 48.24 (n)
  • 34.82 (a)
AVT4 36
  • 17 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C13277g 35
  • 46.56 (n)
  • 34.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for SLC36A4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC36A4 Gene

ENSEMBL:
Gene Tree for SLC36A4 (if available)
TreeFam:
Gene Tree for SLC36A4 (if available)

Paralogs for SLC36A4 Gene

Paralogs for SLC36A4 Gene

Selected SIMAP similar genes for SLC36A4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC36A4: view

Variants for SLC36A4 Gene

Sequence variations from dbSNP and Humsavar for SLC36A4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1613 -- 93,144,367(+) ACATA(C/T)ATTTT utr-variant-3-prime
rs995767 -- 93,154,797(+) CTTGC(A/T)AAGTT intron-variant
rs1062050 -- 93,147,878(-) TTTGA(A/C)AAGGG utr-variant-3-prime
rs1158347 -- 93,162,233(+) CACAA(C/G)AACCC intron-variant
rs1348871 -- 93,188,275(+) AGCAG(C/G)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC36A4 Gene

Variant ID Type Subtype PubMed ID
nsv898173 CNV Loss 21882294
nsv435 CNV Loss 18451855
nsv510593 CNV Complex 20534489
dgv1273n71 CNV Loss 21882294
nsv818858 CNV Loss 17921354
dgv417e1 CNV Complex 17122850
esv33564 CNV Loss 17666407

Relevant External Links for SLC36A4 Gene

HapMap Linkage Disequilibrium report
SLC36A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC36A4 Gene

Disorders for SLC36A4 Gene

No disorders were found for SLC36A4 Gene.

No data available for UniProtKB/Swiss-Prot for SLC36A4 Gene

Publications for SLC36A4 Gene

  1. SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. (PMID: 21097500) Pillai S.M. … Meredith D. (J. Biol. Chem. 2011) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation. (PMID: 20498635) Heublein S. … Goberdhan D.C. (Oncogene 2010) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for SLC36A4 Gene

Sources for SLC36A4 Gene

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