SLC36A4 Gene
protein-coding GIFtS: 43
GCID: GC11M092880
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solute carrier family 36 (proton/amino acid symporter),...
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Aliases
for SLC36A4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 41 2 | | PAT41 2 3 | | Proton/Amino Acid Transporter 42 3 | | Solute Carrier Family 36 Member 42 3 | | FLJ389321 | | Proton-Coupled Amino Acid Transporter 42 |
Export aliases for SLC36A4 gene to outside databasesPrevious GC identifers: GC11M093065 GC11M092569 GC11M092520 GC11M088965 |
Summaries
for SLC36A4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC36A4:
SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members(e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane domains.Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is ahigh-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011 (PubMed21097500)).(supplied by OMIM, Feb 2011)
UniProtKB/Swiss-Prot: S36A4_HUMAN, Q6YBV0Function: Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibitedby sarcosine
|
Genomic Views
for SLC36A4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC36A4 gene promoter:
HFH-3 Sox5 RP58 E4BP4 Tal-1beta E47 FOXI1 Nkx6-1 ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC36A4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC36A4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q21 Ensembl cytogenetic band: 11q21 HGNC cytogenetic band: 11q21SLC36A4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M092880: view genomic region
(about GC identifiers)
Start:
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92,877,341 bp from pter |
End:
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92,931,130 bp from pter |
Size:
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53,790 bases |
Orientation:
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minus strand |
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Proteins
for SLC36A4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S36A4_HUMAN, Q6YBV0 (See
protein sequence)Recommended Name: Proton-coupled amino acid transporter 4 Size: 504 amino acids; 56157 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=CAC82496.1; Type=Frameshift; Positions=358, 361, 363, 366, 370, 373, 376, 387, 396, 458,487;
Secondary accessions: Q86X30 Q8IVM5 Q8N8S6Alternative splicing: 2 isoforms: Q6YBV0-1 Q6YBV0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC36A4: NX_Q6YBV0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6YBV0
SLC36A4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689526.2
ENSEMBL proteins: ENSP00000317382 ENSP00000436570 ENSP00000432061 ENSP00000434879
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC36A4 for ontologies About GeneDecksing
SLC36A4 Antibody Products:
Assay Products for SLC36A4: |
Protein
Domains /
Families
for SLC36A4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC36A4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6YBV0ProtoNet protein and cluster: Q6YBV0 UniProtKB/Swiss-Prot: S36A4_HUMAN, Q6YBV0Similarity: Belongs to the amino acid/polyamine transporter 2 family |
Function
for SLC36A4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S36A4_HUMAN, Q6YBV0Function: Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibitedby sarcosineBiophysicochemical properties: Kinetic parameters: KM=3.1 uM for L-proline; KM=1.7 uM for L-tryptophan; pH dependence:Optimum pH is 7.4 (for proline transport);
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC36A4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC36A4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015293 | symporter activity |
IEA | -- |
SLC36A4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SLC36A4:
|
Pathways & Interactions
for SLC36A4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC36A4
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SLC36A4 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC36A4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC36A4
Search CenterWatch for drugs/clinical trials and news about SLC36A4 / S36A4
|
Transcripts
for SLC36A4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC36A4 gene: NM_152313.2 Unigene Cluster for SLC36A4: Solute carrier family 36 (proton/amino acid symporter), member 4 Hs.148766 [show with all ESTs]Unigene Representative Sequence: AY1622167 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000326402(uc001pdm.3 uc001pdn.3) ENST00000527503 ENST00000529184
ENST00000526735 ENST00000534116 ENST00000524875 ENST00000527743
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC36A4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC36A4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC36A4 (NM_152313) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC36A4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC36A4 |
Additional cDNA sequence: AJ295983.1 AK096251.1 AY162216.1 BC047374.1 7 DOTS entries: DT.100748155 DT.95368669 DT.409655 DT.205616 DT.120708583 DT.120708591 DT.91797616 24/65 AceView cDNA sequences (see all 65): BU181741 F27252 F11232 NM_152313 F08895 BE219231 AA935756 BI019871 AV728696 CD678384 AY162216 AI393765 BG960467 BC047374 AI378686 BI333531 AI216499 AW468398 BX103120 BX645411 BG546562 BX392174 AL542358 AW003704
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC36A4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 |
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| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC36A4
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Expression
for SLC36A4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC36A4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAAGAAAA
About this image
See SLC36A4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC36A4
SOURCE GeneReport for Unigene cluster: Hs.148766
SABiosciences Custom PCR Arrays for SLC36A4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC36A4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC36A4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC36A4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC36A4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC36A4 |
Orthologs
for SLC36A4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for SLC36A4 gene from 7/26 species (see all 26) About this table
ENSEMBL Gene Tree for SLC36A4 (if available)
TreeFam Gene Tree for SLC36A4 (if available) |
Paralogs
for SLC36A4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC36A4 gene
- SLC36A12 SLC36A32 SLC36A22
3 SIMAP similar genes for SLC36A4 using alignment to 3 protein entries: S36A4_HUMAN (see all proteins):SLC36A1 SLC36A2 SLC36A3
SLC36A4 for paralogs About GeneDecksing
|
Genomic Variants
for SLC36A4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC36A4 (92877341 - 92931130 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SLC36A4
3 CNVs: 2946 6955 10374 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC36A4 |
|
Disorders
/ Diseases
for SLC36A4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SLC36A4 for disorders About MalaCards
SLC36A4 for disorders About GeneDecksing
OMIM gene information: 613760
OMIM disorders: --
Export disorders for SLC36A4 gene to outside databases
|
Publications
for SLC36A4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC36A4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC36A4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. (PubMed id 21097500)1, 2 Pillai S.M. and Meredith D. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation. (PubMed id 20498635)1 Heublein S....Goberdhan D.C. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for SLC36A4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC36A4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC36A4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC36A4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC36A4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLC36A4 gene:
Search GeneIP for patents involving SLC36A4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC36A4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 | | | SLC36A4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC36A4 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC36A4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC36A4 |
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