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Aliases for SLC36A4 Gene

Aliases for SLC36A4 Gene

  • Solute Carrier Family 36 Member 4 2 3 4
  • Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 4 2 3 5
  • PAT4 3 4
  • Proton/Amino Acid Transporter 4 4

External Ids for SLC36A4 Gene

Previous GeneCards Identifiers for SLC36A4 Gene

  • GC11M092569
  • GC11M092520
  • GC11M092880
  • GC11M088965

Summaries for SLC36A4 Gene

Entrez Gene Summary for SLC36A4 Gene

  • SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members (e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane domains. Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a high-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011 [PubMed 21097500]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SLC36A4 Gene

SLC36A4 (Solute Carrier Family 36 Member 4) is a Protein Coding gene. GO annotations related to this gene include symporter activity and amino acid transmembrane transporter activity. An important paralog of this gene is SLC36A1.

UniProtKB/Swiss-Prot for SLC36A4 Gene

  • Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC36A4 Gene

Genomics for SLC36A4 Gene

Regulatory Elements for SLC36A4 Gene

Enhancers for SLC36A4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC36A4 on UCSC Golden Path with GeneCards custom track

Promoters for SLC36A4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC36A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC36A4 Gene

93,144,171 bp from pter
93,197,975 bp from pter
53,805 bases
Minus strand

Genomic View for SLC36A4 Gene

Genes around SLC36A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC36A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC36A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC36A4 Gene

Proteins for SLC36A4 Gene

  • Protein details for SLC36A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proton-coupled amino acid transporter 4
    Protein Accession:
    Secondary Accessions:
    • Q86X30
    • Q8IVM5
    • Q8N8S6

    Protein attributes for SLC36A4 Gene

    504 amino acids
    Molecular mass:
    56157 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAC82496.1; Type=Frameshift; Positions=358, 361, 363, 366, 370, 373, 376, 387, 396, 458, 487; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC36A4 Gene


neXtProt entry for SLC36A4 Gene

Proteomics data for SLC36A4 Gene at MOPED

Post-translational modifications for SLC36A4 Gene

  • Glycosylation at Asn 197 and Asn 495
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC36A4 Gene

No data available for DME Specific Peptides for SLC36A4 Gene

Domains & Families for SLC36A4 Gene

Gene Families for SLC36A4 Gene

Protein Domains for SLC36A4 Gene


Suggested Antigen Peptide Sequences for SLC36A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the amino acid/polyamine transporter 2 family.
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC36A4: view

Function for SLC36A4 Gene

Molecular function for SLC36A4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.1 uM for L-proline {ECO:0000269 PubMed:21097500}; KM=1.7 uM for L-tryptophan {ECO:0000269 PubMed:21097500}; pH dependence: Optimum pH is 7.4 (for proline transport). {ECO:0000269 PubMed:21097500};
UniProtKB/Swiss-Prot Function:
Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine.

Gene Ontology (GO) - Molecular Function for SLC36A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC36A4: view
genes like me logo Genes that share phenotypes with SLC36A4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC36A4

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC36A4 Gene

Localization for SLC36A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC36A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC36A4 Gene COMPARTMENTS Subcellular localization image for SLC36A4 gene
Compartment Confidence
plasma membrane 4
cytosol 2
golgi apparatus 2
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SLC36A4 Gene

Pathways & Interactions for SLC36A4 Gene

SuperPathways for SLC36A4 Gene

No Data Available

Interacting Proteins for SLC36A4 Gene

Gene Ontology (GO) - Biological Process for SLC36A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035524 proline transmembrane transport IDA 21097500
genes like me logo Genes that share ontologies with SLC36A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC36A4 Gene

Drugs & Compounds for SLC36A4 Gene

No Compound Related Data Available

Transcripts for SLC36A4 Gene

Unigene Clusters for SLC36A4 Gene

Solute carrier family 36 (proton/amino acid symporter), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC36A4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - -
SP2: - - -

Relevant External Links for SLC36A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC36A4 Gene

mRNA expression in normal human tissues for SLC36A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC36A4 Gene

SOURCE GeneReport for Unigene cluster for SLC36A4 Gene Hs.148766

genes like me logo Genes that share expression patterns with SLC36A4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC36A4 Gene

Orthologs for SLC36A4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC36A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC36A4 35
  • 91.65 (n)
  • 92.61 (a)
SLC36A4 36
  • 92 (a)
(Canis familiaris)
Mammalia SLC36A4 35
  • 92.31 (n)
  • 93.84 (a)
SLC36A4 36
  • 95 (a)
(Mus musculus)
Mammalia Slc36a4 35
  • 83.67 (n)
  • 89.96 (a)
Slc36a4 16
Slc36a4 36
  • 89 (a)
(Pan troglodytes)
Mammalia SLC36A4 35
  • 99.74 (n)
  • 99.8 (a)
SLC36A4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Slc36a4 35
  • 81.97 (n)
  • 88.11 (a)
(Monodelphis domestica)
Mammalia SLC36A4 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia SLC36A4 36
  • 82 (a)
(Gallus gallus)
Aves SLC36A4 35
  • 72.81 (n)
  • 73.98 (a)
SLC36A4 36
  • 73 (a)
(Anolis carolinensis)
Reptilia SLC36A4 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc36a4 35
  • 66.95 (n)
  • 65.96 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32457 35
(Danio rerio)
Actinopterygii slc36a4 35
  • 59.32 (n)
  • 60.13 (a)
slc36a4 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008490 35
  • 48.66 (n)
  • 42.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13384 35
  • 51.06 (n)
  • 42.55 (a)
CG1139 36
  • 30 (a)
CG12943 36
  • 24 (a)
CG13384 36
  • 36 (a)
CG16700 36
  • 32 (a)
CG32079 36
  • 25 (a)
CG32081 36
  • 27 (a)
CG43693 36
  • 28 (a)
CG4991 36
  • 27 (a)
CG7888 36
  • 32 (a)
CG8785 36
  • 31 (a)
path 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea C44B7.6 36
  • 26 (a)
F59B2.2 36
  • 24 (a)
H32K16.1 36
  • 27 (a)
T27A1.5 36
  • 32 (a)
Y38H6C.17 36
  • 25 (a)
Y43F4B.7 36
  • 30 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER380C 35
  • 45.45 (n)
  • 31.57 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C13277g 35
  • 46.56 (n)
  • 34.71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT4 35
  • 48.24 (n)
  • 34.82 (a)
AVT3 36
  • 15 (a)
AVT4 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for SLC36A4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC36A4 Gene

Gene Tree for SLC36A4 (if available)
Gene Tree for SLC36A4 (if available)

Paralogs for SLC36A4 Gene

Paralogs for SLC36A4 Gene

(3) SIMAP similar genes for SLC36A4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC36A4: view

Variants for SLC36A4 Gene

Sequence variations from dbSNP and Humsavar for SLC36A4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17854446 - 93,168,087(+) CCTTA(G/T)GTCAA reference, missense, utr-variant-5-prime
rs17854445 - 93,154,188(+) TCCCA(G/T)GGATA reference, missense, utr-variant-3-prime
rs17854443 - 93,148,767(+) GATTA(G/T)GGCCA reference, missense
rs995767 -- 93,154,797(+) CTTGC(A/T)AAGTT intron-variant
rs1062050 -- 93,147,878(-) TTTGA(A/C)AAGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC36A4 Gene

Variant ID Type Subtype PubMed ID
nsv898173 CNV Loss 21882294
nsv435 CNV Loss 18451855
nsv510593 CNV Complex 20534489
dgv1273n71 CNV Loss 21882294
nsv818858 CNV Loss 17921354
dgv417e1 CNV Complex 17122850
esv33564 CNV Loss 17666407

Variation tolerance for SLC36A4 Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC36A4 Gene

Disorders for SLC36A4 Gene

Relevant External Links for SLC36A4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC36A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC36A4 Gene

Publications for SLC36A4 Gene

  1. SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. (PMID: 21097500) Pillai S.M. … Meredith D. (J. Biol. Chem. 2011) 3 4 67
  2. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. (PMID: 23506890) SchiAPth H.B. … Fredriksson R. (Mol. Aspects Med. 2013) 3
  3. Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer. (PMID: 23719583) Kerns S.L. … Ostrer H. (Radiother Oncol 2013) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation. (PMID: 20498635) Heublein S. … Goberdhan D.C. (Oncogene 2010) 3

Products for SLC36A4 Gene

Sources for SLC36A4 Gene