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SLC36A4 Gene

protein-coding   GIFtS: 47
GCID: GC11M092880

Solute Carrier Family 36 (Proton/Amino Acid Symporter),...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 41 2
PAT42 3 5
Proton-Coupled Amino Acid Transporter 42
Proton/Amino Acid Transporter 43
Solute Carrier Family 36 Member 43

External Ids:    HGNC: 196601   Entrez Gene: 1201032   Ensembl: ENSG000001807737   OMIM: 6137605   UniProtKB: Q6YBV03   

Export aliases for SLC36A4 gene to outside databases

Previous GC identifers: GC11M093065 GC11M092569 GC11M092520 GC11M088965


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC36A4 Gene:
SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family
members (e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane
domains. Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a
high-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011 (PubMed
21097500)).(supplied by OMIM, Feb 2011)

GeneCards Summary for SLC36A4 Gene:
SLC36A4 (solute carrier family 36 (proton/amino acid symporter), member 4) is a protein-coding gene. Diseases associated with SLC36A4 include obesity, and malaria. GO annotations related to this gene include symporter activity. An important paralog of this gene is SLC36A1.

UniProtKB/Swiss-Prot: S36A4_HUMAN, Q6YBV0
Function: Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine.
Inhibited by sarcosine




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC36A4 gene promoter:
         HFH-3   Sox5   RP58   E4BP4   Tal-1beta   E47   FOXI1   Nkx6-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC36A4 promoter sequence
   Search Chromatin IP Primers for SLC36A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC36A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21   Ensembl cytogenetic band:  11q21   HGNC cytogenetic band: 11q21

SLC36A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC36A4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M092880:  view genomic region     (about GC identifiers)

Start:
92,877,341 bp from pter      End:
92,931,130 bp from pter
Size:
53,790 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: S36A4_HUMAN, Q6YBV0 (See protein sequence)
Recommended Name: Proton-coupled amino acid transporter 4  
Size: 504 amino acids; 56157 Da
Sequence caution: Sequence=CAC82496.1; Type=Frameshift; Positions=358, 361, 363, 366, 370, 373, 376, 387, 396,
458, 487;
Secondary accessions: Q86X30 Q8IVM5 Q8N8S6
Alternative splicing: 2 isoforms:  Q6YBV0-1   Q6YBV0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC36A4: NX_Q6YBV0

Explore proteomics data for SLC36A4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn194, Asn197, Asn495
  • Modification sites at PhosphoSitePlus

  • See SLC36A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273068.1  NP_689526.2  

    ENSEMBL proteins: 
     ENSP00000317382   ENSP00000436570   ENSP00000432061   ENSP00000434879  

    SLC36A4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SLC36A4

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    SLC36A4 Assay Products:

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    Cloud-Clone Corp. ELISAs for SLC36A4
    Cloud-Clone Corp. CLIAs for SLC36A4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Proton-coupled Amino acid Transporter 4
    SLC36 family of proton-coupled amino acid transporters

    1 InterPro protein domain:
     IPR013057 AA_transpt_TM

    Graphical View of Domain Structure for InterPro Entry Q6YBV0

    ProtoNet protein and cluster: Q6YBV0

    UniProtKB/Swiss-Prot: S36A4_HUMAN, Q6YBV0
    Similarity: Belongs to the amino acid/polyamine transporter 2 family


    SLC36A4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S36A4_HUMAN, Q6YBV0
    Function: Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine.
    Inhibited by sarcosine
    Biophysicochemical properties: Kinetic parameters: KM=3.1 uM for L-proline; KM=1.7 uM for L-tryptophan; pH
    dependence: Optimum pH is 7.4 (for proline transport);

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015293symporter activity IEA--
         
    SLC36A4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC36A4:
     Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC36A4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC36A4
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    miRNA
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    Block miRNA regulation of human, mouse, rat SLC36A4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SLC36A4:
    hsa-miR-653
    SwitchGear 3'UTR luciferase reporter plasmidSLC36A4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC36A4
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SLC36A4 (NM_152313)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC36A4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S36A4_HUMAN, Q6YBV0: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    SLC36A4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC36A4
    Interactions:

        Search GeneGlobe Interaction Network for SLC36A4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SLC36A4 (ENSP000003173824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP6CENSP000003921474STRING: ENSP00000392147
    PPP2CAENSP000004184474STRING: ENSP00000418447
    PPP2CBENSP000002211384STRING: ENSP00000221138
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015808L-alanine transport IDA--
    GO:0015824proline transport IDA--
    GO:0015827tryptophan transport IDA--

    SLC36A4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC36A4 (S36A4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC36A4 gene (2 alternative transcripts): 
    NM_001286139.1  NM_152313.3  

    Unigene Cluster for SLC36A4:

    Solute carrier family 36 (proton/amino acid symporter), member 4
    Hs.148766  [show with all ESTs]
    Unigene Representative Sequence: AY162216
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326402(uc001pdm.3 uc001pdn.3) ENST00000527503 ENST00000529184
    ENST00000526735 ENST00000534116 ENST00000524875 ENST00000527743
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC36A4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SLC36A4:
    hsa-miR-653
    SwitchGear 3'UTR luciferase reporter plasmidSLC36A4 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC36A4
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    GenScript: all cDNA clones in your preferred vector: SLC36A4 (NM_152313)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC36A4
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC36A4
      QuantiTect SYBR Green Assays in human, mouse, rat SLC36A4
      QuantiFast Probe-based Assays in human, mouse, rat SLC36A4

    Additional mRNA sequence: 

    AJ295983.1 AK096251.1 AY162216.1 BC047374.1 

    7 DOTS entries:

    DT.100748155  DT.95368669  DT.409655  DT.205616  DT.120708583  DT.120708591  DT.91797616 

    Selected AceView cDNA sequences (see all 65):

    F27252 AV728696 CD678384 F11232 AY162216 NM_152313 AI393765 AA935756 
    BU181741 F08895 BI019871 BE219231 BG705882 AW014007 F07606 AI692279 
    BX103120 BI256185 BG960467 BX645411 BC047374 BI333531 BX392174 AL542358 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC36A4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
    SP1:                    -                                                                 -         
    SP2:                    -                 -                                               -         
    SP3:                                                                                                
    SP4:                                                                                                


    ECgene alternative splicing isoforms for SLC36A4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC36A4 expression in normal human tissues (normalized intensities)      SLC36A4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAAGAAAA
    SLC36A4 Expression
    About this image


    SLC36A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    SLC36A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC36A4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.148766
        Custom PCR Arrays for SLC36A4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC36A4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC36A4 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc36a41 , 5 solute carrier family 36 (proton/amino acid symporter), more1, 5 83.67(n)1
    89.96(a)1
      9 (5.12 cM)5
    2349671  NM_172289.41  NP_758493.21 
     157097385 
    chicken
    (Gallus gallus)
    Aves SLC36A41 solute carrier family 36 (proton/amino acid symporter), more 72.81(n)
    73.98(a)
      419007  XM_417200.4  XP_417200.4 
    lizard
    (Anolis carolinensis)
    Reptilia SLC36A46
    solute carrier family 36 (proton/amino acid sympor...
    71(a)
    1 ↔ 1
    3(196429715-196489271)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.324572 Xenopus laevis transcribed sequence with weak similarity more 72.89(n)    BJ617827.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc36a41 solute carrier family 36 (proton/amino acid symporter), more 59.32(n)
    60.13(a)
      504109  XM_002664695.3  XP_002664741.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG133841 CG13384 51.06(n)
    42.55(a)
      34160  NM_205936.3  NP_995658.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T27A1.56
    Y43F4B.76
    (see all 6)
    Protein Y43F4B.7 (Y43F4B.7) mRNA, complete cds
    (see all 6)
    32(a)
    30(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    II(522594-525975) WBGene00020837
    III(13307502-13313393) WBGene00012804
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AVT41 AVT4 48.24(n)
    34.82(a)
      855622   NP_014298.1 


    ENSEMBL Gene Tree for SLC36A4 (if available)
    TreeFam Gene Tree for SLC36A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC36A4 gene
    SLC36A12  SLC36A32  SLC36A22  
    3 SIMAP similar genes for SLC36A4 using alignment to 3 protein entries:     S36A4_HUMAN (see all proteins):
    SLC36A1    SLC36A2    SLC36A3

    SLC36A4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC36A4 (see all 899)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880041661,2
    --92880411(+) TCCTCC/TAGAGT 1 -- int10--------
    rs3710775241,2
    C--92880533(+) CCTCCA/GTTTCT 1 -- int10--------
    rs798108361,2
    C,F--92880568(+) AGGAAT/CGTGGT 1 -- int11Minor allele frequency- C:0.10NA 120
    rs1925693911,2
    --92880594(+) GAAAGG/TAAGGT 1 -- int10--------
    rs3689041001,2
    C--92880613(+) AAAAA-/GCTC  
            
    AAGCC
    1 -- int10--------
    rs2019751361,2
    C--92880616(-) GGCTTG/TAGCTT 1 -- int10--------
    rs1508885761,2
    --92880670(+) CACCAC/GCAAGC 1 -- int10--------
    rs1393566891,2
    --92880745(+) GTAGGA/CTTCTT 1 -- int10--------
    rs1843148221,2
    --92880815(+) CAAAGG/TATTAA 1 -- int10--------
    rs1896443601,2
    --92880952(+) GCTGAC/GTGGTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC36A4 (92877341 - 92931130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SLC36A4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv435CNV Loss18451855
    nsv898173CNV Loss21882294
    nsv818858CNV Loss17921354
    dgv1273n71CNV Loss21882294
    esv33564CNV Loss17666407
    nsv510593CNV Complex20534489
    dgv417e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC36A4
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC36A4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613760    OMIM disorders: --

    2 diseases for SLC36A4:    About MalaCards
    obesity    malaria


    SLC36A4 for disorders           About GeneDecksing


    Export disorders for SLC36A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC36A4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SLC36A4)
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    1. SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. (PubMed id 21097500)1, 2 Pillai S.M. and Meredith D. (J. Biol. Chem. 2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer. (PubMed id 23719583)1 Kerns S.L....Ostrer H. (Radiother Oncol 2013)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation. (PubMed id 20498635)1 Heublein S....Goberdhan D.C. (Oncogene 2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 120103 HGNC: 19660 AceView: SLC36A4 Ensembl:ENSG00000180773 euGenes: HUgn120103
    ECgene: SLC36A4 H-InvDB: SLC36A4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC36A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC36A4 gene:
    Search GeneIP for patents involving SLC36A4

    GeneCards and IP:
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