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Aliases for SLC36A3 Gene

Aliases for SLC36A3 Gene

  • Solute Carrier Family 36 Member 3 2 3 4 5
  • Proton/Amino Acid Transporter 3 3 4
  • TRAMD2 3 4
  • PAT3 3 4
  • Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 3 3
  • Proton-Coupled Amino Acid Transporter 3 3
  • Solute Carrier Family 36, Member 3 2
  • Tramdorin 2 3
  • Tramdorin-2 4
  • Tramdorin2 3

External Ids for SLC36A3 Gene

Previous GeneCards Identifiers for SLC36A3 Gene

  • GC05M150647
  • GC05M150684
  • GC05M150636
  • GC05M145801

Summaries for SLC36A3 Gene

GeneCards Summary for SLC36A3 Gene

SLC36A3 (Solute Carrier Family 36 Member 3) is a Protein Coding gene. GO annotations related to this gene include hydrogen ion transmembrane transporter activity and glycine transmembrane transporter activity. An important paralog of this gene is SLC36A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC36A3 Gene

Genomics for SLC36A3 Gene

Regulatory Elements for SLC36A3 Gene

Enhancers for SLC36A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F151595 0.5 FANTOM5 30.7 -282.3 -282311 0.3 EGR2 SLC36A3 FAT2 SPARC LOC105378231 MIR6499
GH05F151706 1.4 FANTOM5 Ensembl ENCODE 4.5 -395.2 -395171 2.7 ELF3 HDGF TBP CBX3 ATF1 BMI1 YY1 RARA ZNF121 SCRT2 SPARC CTB-113P19.1 SLC36A3 RN7SKP232 ENSG00000272112
GH05F151250 1.5 FANTOM5 ENCODE 0.2 +57.7 57686 9.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS GM2A ANXA6 SLC36A1 TNIP1 CCDC69 DCTN4 SMIM3 SLC36A3
GH05F151298 0.7 Ensembl 0.4 +14.6 14581 0.4 ZNF263 SCRT1 CTCF ZNF654 PKNOX1 TRIM22 RAD21 RAD51 SCRT2 IKZF1 GM2A SLC36A3 CCDC69
GH05F151237 1.2 Ensembl ENCODE 0.2 +73.1 73139 4.3 HDGF TBL1XR1 ARID4B RAD21 YY1 ZNF366 ELK1 SCRT2 ZNF143 FOS GM2A CCDC69 SLC36A3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC36A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC36A3 Gene

Chromosome:
5
Start:
151,276,365 bp from pter
End:
151,312,981 bp from pter
Size:
36,617 bases
Orientation:
Minus strand

Genomic View for SLC36A3 Gene

Genes around SLC36A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC36A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC36A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC36A3 Gene

Proteins for SLC36A3 Gene

  • Protein details for SLC36A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q495N2-S36A3_HUMAN
    Recommended name:
    Proton-coupled amino acid transporter 3
    Protein Accession:
    Q495N2
    Secondary Accessions:
    • Q495N3
    • Q6ZMU7
    • Q6ZRU4
    • Q7Z6B4

    Protein attributes for SLC36A3 Gene

    Size:
    470 amino acids
    Molecular mass:
    51735 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC36A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC36A3 Gene

Post-translational modifications for SLC36A3 Gene

No data available for DME Specific Peptides for SLC36A3 Gene

Domains & Families for SLC36A3 Gene

Gene Families for SLC36A3 Gene

Protein Domains for SLC36A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC36A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q495N2

UniProtKB/Swiss-Prot:

S36A3_HUMAN :
  • Belongs to the amino acid/polyamine transporter 2 family.
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC36A3: view

Function for SLC36A3 Gene

Gene Ontology (GO) - Molecular Function for SLC36A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005280 hydrogen:amino acid symporter activity IBA --
GO:0015078 hydrogen ion transmembrane transporter activity IBA --
GO:0015180 L-alanine transmembrane transporter activity IBA --
GO:0015187 glycine transmembrane transporter activity IBA --
GO:0015193 L-proline transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC36A3: view
genes like me logo Genes that share phenotypes with SLC36A3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC36A3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC36A3 Gene

Localization for SLC36A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC36A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC36A3 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SLC36A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC36A3: view

Pathways & Interactions for SLC36A3 Gene

SuperPathways for SLC36A3 Gene

No Data Available

Interacting Proteins for SLC36A3 Gene

Gene Ontology (GO) - Biological Process for SLC36A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015808 L-alanine transport IEA --
GO:0015816 glycine transport IBA --
GO:0015992 proton transport IEA --
GO:0035524 proline transmembrane transport IEA --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC36A3: view

No data available for Pathways by source and SIGNOR curated interactions for SLC36A3 Gene

Transcripts for SLC36A3 Gene

mRNA/cDNA for SLC36A3 Gene

(8) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC36A3 Gene

Solute carrier family 36 (proton/amino acid symporter), member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC36A3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: - -

Relevant External Links for SLC36A3 Gene

GeneLoc Exon Structure for
SLC36A3
ECgene alternative splicing isoforms for
SLC36A3

Expression for SLC36A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC36A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC36A3 Gene

This gene is overexpressed in Testis (x50.4).

NURSA nuclear receptor signaling pathways regulating expression of SLC36A3 Gene:

SLC36A3

SOURCE GeneReport for Unigene cluster for SLC36A3 Gene:

Hs.720893

mRNA Expression by UniProt/SwissProt for SLC36A3 Gene:

Q495N2-S36A3_HUMAN
Tissue specificity: Specifically expressed in testis.
genes like me logo Genes that share expression patterns with SLC36A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SLC36A3 Gene

Orthologs for SLC36A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC36A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC36A3 34 35
  • 99.15 (n)
cow
(Bos Taurus)
Mammalia SLC36A3 34 35
  • 89.36 (n)
dog
(Canis familiaris)
Mammalia SLC36A3 34 35
  • 88.91 (n)
mouse
(Mus musculus)
Mammalia Slc36a3 34 16 35
  • 82.99 (n)
rat
(Rattus norvegicus)
Mammalia Slc36a3 34
  • 81.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 59 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SLC36A3 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii slc36a1 35
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13384 35
  • 33 (a)
ManyToMany
CG1139 35
  • 32 (a)
ManyToMany
CG7888 35
  • 31 (a)
ManyToMany
CG16700 35
  • 30 (a)
ManyToMany
CG32079 35
  • 30 (a)
ManyToMany
CG8785 35
  • 28 (a)
ManyToMany
path 35
  • 28 (a)
ManyToMany
CG32081 35
  • 27 (a)
ManyToMany
CG43693 35
  • 27 (a)
ManyToMany
CG4991 35
  • 27 (a)
ManyToMany
CG12943 35
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y43F4B.7 35
  • 29 (a)
ManyToMany
T27A1.5 35
  • 28 (a)
ManyToMany
Y38H6C.17 35
  • 26 (a)
ManyToMany
C44B7.6 35
  • 25 (a)
ManyToMany
H32K16.1 35
  • 24 (a)
ManyToMany
F59B2.2 35
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT4 35
  • 17 (a)
ManyToMany
AVT3 35 37
  • 16 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G42005 34
  • 45.02 (n)
rice
(Oryza sativa)
Liliopsida Os04g0565500 34
  • 46.01 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToMany
Species where no ortholog for SLC36A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC36A3 Gene

ENSEMBL:
Gene Tree for SLC36A3 (if available)
TreeFam:
Gene Tree for SLC36A3 (if available)

Paralogs for SLC36A3 Gene

Paralogs for SLC36A3 Gene

(3) SIMAP similar genes for SLC36A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC36A3: view

Variants for SLC36A3 Gene

Sequence variations from dbSNP and Humsavar for SLC36A3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10038654 -- 151,302,747(+) AAATT(A/T)AATTT intron-variant
rs10040217 -- 151,283,777(+) CCCAC(C/G)GTCAC intron-variant, downstream-variant-500B
rs10043121 -- 151,283,749(+) CATTA(G/T)CTATG intron-variant, downstream-variant-500B
rs10043175 -- 151,284,000(+) AACAG(A/T)TCCAG intron-variant, downstream-variant-500B
rs10045696 -- 151,283,752(+) TATCT(A/G)TGTAT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC36A3 Gene

Variant ID Type Subtype PubMed ID
nsv1032558 CNV loss 25217958
esv6641 CNV loss 19470904

Variation tolerance for SLC36A3 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC36A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC36A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC36A3 Gene

Disorders for SLC36A3 Gene

Relevant External Links for SLC36A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC36A3

No disorders were found for SLC36A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC36A3 Gene

Publications for SLC36A3 Gene

  1. A cluster of proton/amino acid transporter genes in the human and mouse genomes. (PMID: 12809675) Boll M. … Daniel H. (Genomics 2003) 2 3 4 64
  2. Organization and expression of the SLC36 cluster of amino acid transporter genes. (PMID: 15058382) Bermingham J.R. Jr. … Pennington J. (Mamm. Genome 2004) 3 4 64
  3. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. (PMID: 23506890) SchiAPth H.B. … Fredriksson R. (Mol. Aspects Med. 2013) 3 64
  4. Mechanisms of lysophosphatidic acid (LPA) mediated stimulation of intestinal apical Cl-/OH- exchange. (PMID: 19910524) Singla A. … Dudeja P.K. (Am. J. Physiol. Gastrointest. Liver Physiol. 2010) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for SLC36A3 Gene

Sources for SLC36A3 Gene

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