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Aliases for SLC36A3 Gene

Aliases for SLC36A3 Gene

  • Solute Carrier Family 36, Member 3 2 3
  • Proton/Amino Acid Transporter 3 3 4
  • Tramdorin-2 3 4
  • TRAMD2 3 4
  • PAT3 3 4
  • Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 3 3
  • Proton-Coupled Amino Acid Transporter 3 3
  • Solute Carrier Family 36 Member 3 4
  • Tramdorin 2 3
  • Tramdorin2 3

External Ids for SLC36A3 Gene

Previous GeneCards Identifiers for SLC36A3 Gene

  • GC05M150647
  • GC05M150684
  • GC05M150636
  • GC05M145801

Summaries for SLC36A3 Gene

GeneCards Summary for SLC36A3 Gene

SLC36A3 (Solute Carrier Family 36, Member 3) is a Protein Coding gene. An important paralog of this gene is SLC36A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC36A3 Gene

Genomics for SLC36A3 Gene

Regulatory Elements for SLC36A3 Gene

Genomic Location for SLC36A3 Gene

Start:
151,276,365 bp from pter
End:
151,303,782 bp from pter
Size:
27,418 bases
Orientation:
Minus strand

Genomic View for SLC36A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC36A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC36A3 Gene

Proteins for SLC36A3 Gene

  • Protein details for SLC36A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q495N2-S36A3_HUMAN
    Recommended name:
    Proton-coupled amino acid transporter 3
    Protein Accession:
    Q495N2
    Secondary Accessions:
    • Q495N3
    • Q6ZMU7
    • Q6ZRU4
    • Q7Z6B4

    Protein attributes for SLC36A3 Gene

    Size:
    470 amino acids
    Molecular mass:
    51735 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC36A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC36A3 Gene

Proteomics data for SLC36A3 Gene at MOPED

Post-translational modifications for SLC36A3 Gene

Other Protein References for SLC36A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC36A3 Gene

Domains for SLC36A3 Gene

Gene Families for SLC36A3 Gene

Protein Domains for SLC36A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC36A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q495N2

UniProtKB/Swiss-Prot:

S36A3_HUMAN :
  • Q495N2
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC36A3: view

Function for SLC36A3 Gene

Gene Ontology (GO) - Molecular Function for SLC36A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005280 hydrogen:amino acid symporter activity IBA --
GO:0015078 hydrogen ion transmembrane transporter activity IBA --
GO:0015180 L-alanine transmembrane transporter activity IBA --
GO:0015187 glycine transmembrane transporter activity IBA --
GO:0015193 L-proline transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC36A3: view

Phenotypes for SLC36A3 Gene

GenomeRNAi human phenotypes for SLC36A3:
genes like me logo Genes that share phenotypes with SLC36A3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC36A3 Gene

Localization for SLC36A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC36A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC36A3 Gene COMPARTMENTS Subcellular localization image for SLC36A3 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC36A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005774 vacuolar membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC36A3: view

Pathways for SLC36A3 Gene

SuperPathways for SLC36A3 Gene

No Data Available

Interacting Proteins for SLC36A3 Gene

Gene Ontology (GO) - Biological Process for SLC36A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015808 L-alanine transport IBA --
GO:0015816 glycine transport IBA --
GO:0015992 proton transport IBA --
GO:0035524 proline transmembrane transport IBA --
GO:1902600 hydrogen ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC36A3: view

No data available for Pathways by source for SLC36A3 Gene

Transcripts for SLC36A3 Gene

mRNA/cDNA for SLC36A3 Gene

(8) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(12) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC36A3 Gene

Solute carrier family 36 (proton/amino acid symporter), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC36A3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC36A3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC36A3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: - -

Relevant External Links for SLC36A3 Gene

GeneLoc Exon Structure for
SLC36A3
ECgene alternative splicing isoforms for
SLC36A3

Expression for SLC36A3 Gene

mRNA expression in normal human tissues for SLC36A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC36A3 Gene

This gene is overexpressed in Testis (50.4).

SOURCE GeneReport for Unigene cluster for SLC36A3 Gene Hs.720893

mRNA Expression by UniProt/SwissProt for SLC36A3 Gene

Q495N2-S36A3_HUMAN
Tissue specificity: Specifically expressed in testis.
genes like me logo Genes that share expressions with SLC36A3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for SLC36A3 Gene

Orthologs for SLC36A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC36A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC36A3 35
  • 99.15 (n)
  • 98.72 (a)
SLC36A3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC36A3 35
  • 89.36 (n)
  • 85.53 (a)
SLC36A3 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC36A3 35
  • 88.91 (n)
  • 86.14 (a)
SLC36A3 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc36a3 35
  • 82.99 (n)
  • 78.52 (a)
Slc36a3 16
Slc36a3 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC36A3 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc36a3 35
  • 81.57 (n)
  • 77.88 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii slc36a1 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1139 36
  • 32 (a)
ManyToMany
CG12943 36
  • 25 (a)
ManyToMany
CG13384 36
  • 33 (a)
ManyToMany
CG16700 36
  • 30 (a)
ManyToMany
CG32079 36
  • 30 (a)
ManyToMany
CG32081 36
  • 27 (a)
ManyToMany
CG43693 36
  • 27 (a)
ManyToMany
CG4991 36
  • 27 (a)
ManyToMany
CG7888 36
  • 31 (a)
ManyToMany
CG8785 36
  • 28 (a)
ManyToMany
path 36
  • 28 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C44B7.6 36
  • 25 (a)
ManyToMany
F59B2.2 36
  • 22 (a)
ManyToMany
H32K16.1 36
  • 24 (a)
ManyToMany
T27A1.5 36
  • 28 (a)
ManyToMany
Y38H6C.17 36
  • 26 (a)
ManyToMany
Y43F4B.7 36
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT3 36
  • 16 (a)
ManyToMany
AVT3 38
AVT4 36
  • 17 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G42005 35
  • 45.02 (n)
  • 32.22 (a)
rice
(Oryza sativa)
Liliopsida Os04g0565500 35
  • 46.01 (n)
  • 30.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for SLC36A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC36A3 Gene

ENSEMBL:
Gene Tree for SLC36A3 (if available)
TreeFam:
Gene Tree for SLC36A3 (if available)

Paralogs for SLC36A3 Gene

Paralogs for SLC36A3 Gene

Selected SIMAP similar genes for SLC36A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC36A3: view

Variants for SLC36A3 Gene

Sequence variations from dbSNP and Humsavar for SLC36A3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs173493 -- 151,301,753(+) Cctcc(A/G)gtctc intron-variant
rs190309 -- 151,293,826(+) ATTGC(C/T)GATGG intron-variant
rs246476 -- 151,305,277(-) ggtgt(A/C/G/T)ggtct upstream-variant-2KB
rs246498 -- 151,300,722(+) TGAGA(C/T)TTAAA intron-variant
rs246499 -- 151,288,210(-) ATAGA(C/T)GAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC36A3 Gene

Variant ID Type Subtype PubMed ID
esv6641 CNV Loss 19470904

Relevant External Links for SLC36A3 Gene

HapMap Linkage Disequilibrium report
SLC36A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC36A3 Gene

Disorders for SLC36A3 Gene

No disorders were found for SLC36A3 Gene.

No data available for UniProtKB/Swiss-Prot for SLC36A3 Gene

Publications for SLC36A3 Gene

  1. A cluster of proton/amino acid transporter genes in the human and mouse genomes. (PMID: 12809675) Boll M. … Daniel H. (Genomics 2003) 2 3 4
  2. Organization and expression of the SLC36 cluster of amino acid transporter genes. (PMID: 15058382) Bermingham J.R. Jr. … Pennington J. (Mamm. Genome 2004) 3 4
  3. Mechanisms of lysophosphatidic acid (LPA) mediated stimulation of intestinal apical Cl-/OH- exchange. (PMID: 19910524) Singla A. … Dudeja P.K. (Am. J. Physiol. Gastrointest. Liver Physiol. 2010) 3
  4. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. (PMID: 23506890) SchiAPth H.B. … Fredriksson R. (Mol. Aspects Med. 2013) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for SLC36A3 Gene

  • antibodies-online peptides for SLC36A3
  • antibodies-online antibodies for SLC36A3
  • antibodies-online kits for SLC36A3

Sources for SLC36A3 Gene

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