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Aliases for SLC36A3 Gene

Aliases for SLC36A3 Gene

  • Solute Carrier Family 36 Member 3 2 3 4 5
  • Proton/Amino Acid Transporter 3 3 4
  • Tramdorin-2 3 4
  • TRAMD2 3 4
  • PAT3 3 4
  • Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 3 3
  • Proton-Coupled Amino Acid Transporter 3 3
  • Solute Carrier Family 36, Member 3 2
  • Tramdorin 2 3
  • Tramdorin2 3

External Ids for SLC36A3 Gene

Previous GeneCards Identifiers for SLC36A3 Gene

  • GC05M150647
  • GC05M150684
  • GC05M150636
  • GC05M145801

Summaries for SLC36A3 Gene

GeneCards Summary for SLC36A3 Gene

SLC36A3 (Solute Carrier Family 36 Member 3) is a Protein Coding gene. GO annotations related to this gene include hydrogen ion transmembrane transporter activity and glycine transmembrane transporter activity. An important paralog of this gene is SLC36A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC36A3 Gene

Genomics for SLC36A3 Gene

Regulatory Elements for SLC36A3 Gene

Enhancers for SLC36A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SLC36A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC36A3 Gene

151,276,365 bp from pter
151,312,981 bp from pter
36,617 bases
Minus strand

Genomic View for SLC36A3 Gene

Genes around SLC36A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC36A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC36A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC36A3 Gene

Proteins for SLC36A3 Gene

  • Protein details for SLC36A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proton-coupled amino acid transporter 3
    Protein Accession:
    Secondary Accessions:
    • Q495N3
    • Q6ZMU7
    • Q6ZRU4
    • Q7Z6B4

    Protein attributes for SLC36A3 Gene

    470 amino acids
    Molecular mass:
    51735 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC36A3 Gene


neXtProt entry for SLC36A3 Gene

Post-translational modifications for SLC36A3 Gene

Other Protein References for SLC36A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC36A3 Gene

Domains & Families for SLC36A3 Gene

Gene Families for SLC36A3 Gene

Protein Domains for SLC36A3 Gene


Suggested Antigen Peptide Sequences for SLC36A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the amino acid/polyamine transporter 2 family.
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC36A3: view

Function for SLC36A3 Gene

Gene Ontology (GO) - Molecular Function for SLC36A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005280 hydrogen:amino acid symporter activity IBA --
GO:0015078 hydrogen ion transmembrane transporter activity IBA --
GO:0015180 L-alanine transmembrane transporter activity IBA --
GO:0015187 glycine transmembrane transporter activity IBA --
GO:0015193 L-proline transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC36A3: view
genes like me logo Genes that share phenotypes with SLC36A3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC36A3

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC36A3 Gene

Localization for SLC36A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC36A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC36A3 Gene COMPARTMENTS Subcellular localization image for SLC36A3 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SLC36A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC36A3: view

Pathways & Interactions for SLC36A3 Gene

SuperPathways for SLC36A3 Gene

No Data Available

Interacting Proteins for SLC36A3 Gene

Gene Ontology (GO) - Biological Process for SLC36A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015808 L-alanine transport IEA --
GO:0015816 glycine transport IBA --
GO:0035524 proline transmembrane transport IEA --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC36A3: view

No data available for Pathways by source and SIGNOR curated interactions for SLC36A3 Gene

Drugs & Compounds for SLC36A3 Gene

No Compound Related Data Available

Transcripts for SLC36A3 Gene

mRNA/cDNA for SLC36A3 Gene

(8) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC36A3 Gene

Solute carrier family 36 (proton/amino acid symporter), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC36A3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: - -

Relevant External Links for SLC36A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC36A3 Gene

mRNA expression in normal human tissues for SLC36A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC36A3 Gene

This gene is overexpressed in Testis (x50.4).

NURSA nuclear receptor signaling pathways regulating expression of SLC36A3 Gene:


SOURCE GeneReport for Unigene cluster for SLC36A3 Gene:


mRNA Expression by UniProt/SwissProt for SLC36A3 Gene:

Tissue specificity: Specifically expressed in testis.
genes like me logo Genes that share expression patterns with SLC36A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SLC36A3 Gene

Orthologs for SLC36A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC36A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC36A3 34
  • 89.36 (n)
  • 85.53 (a)
SLC36A3 35
  • 84 (a)
(Canis familiaris)
Mammalia SLC36A3 34
  • 88.91 (n)
  • 86.14 (a)
SLC36A3 35
  • 80 (a)
(Mus musculus)
Mammalia Slc36a3 34
  • 82.99 (n)
  • 78.52 (a)
Slc36a3 16
Slc36a3 35
  • 73 (a)
(Pan troglodytes)
Mammalia SLC36A3 34
  • 99.15 (n)
  • 98.72 (a)
SLC36A3 35
  • 98 (a)
(Rattus norvegicus)
Mammalia Slc36a3 34
  • 81.57 (n)
  • 77.88 (a)
(Monodelphis domestica)
Mammalia SLC36A3 35
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 59 (a)
(Gallus gallus)
Aves -- 35
  • 54 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 58 (a)
(Danio rerio)
Actinopterygii slc36a1 35
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1139 35
  • 32 (a)
CG12943 35
  • 25 (a)
CG13384 35
  • 33 (a)
CG16700 35
  • 30 (a)
CG32079 35
  • 30 (a)
CG32081 35
  • 27 (a)
CG43693 35
  • 27 (a)
CG4991 35
  • 27 (a)
CG7888 35
  • 31 (a)
CG8785 35
  • 28 (a)
path 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea C44B7.6 35
  • 25 (a)
F59B2.2 35
  • 22 (a)
H32K16.1 35
  • 24 (a)
T27A1.5 35
  • 28 (a)
Y38H6C.17 35
  • 26 (a)
Y43F4B.7 35
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT3 35
  • 16 (a)
AVT4 35
  • 17 (a)
AVT3 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G42005 34
  • 45.02 (n)
  • 32.22 (a)
(Oryza sativa)
Liliopsida Os04g0565500 34
  • 46.01 (n)
  • 30.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
Species where no ortholog for SLC36A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC36A3 Gene

Gene Tree for SLC36A3 (if available)
Gene Tree for SLC36A3 (if available)

Paralogs for SLC36A3 Gene

Paralogs for SLC36A3 Gene

(3) SIMAP similar genes for SLC36A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC36A3: view

Variants for SLC36A3 Gene

Sequence variations from dbSNP and Humsavar for SLC36A3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs978012 - 151,287,455(-) TGGAA(A/G)AAGCC nc-transcript-variant, reference, missense
rs12520516 - 151,287,401(+) GATGG(A/G)GGTCA nc-transcript-variant, reference, missense
rs17660042 - 151,287,385(+) AGAAA(C/T)GAATG nc-transcript-variant, reference, synonymous-codon, missense
rs13155282 - 151,277,561(+) ACGAT(A/C)TCCAG nc-transcript-variant, reference, missense
rs13155520 - 151,277,544(+) CCTCA(A/C/G)AGTAA nc-transcript-variant, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC36A3 Gene

Variant ID Type Subtype PubMed ID
esv6641 CNV loss 19470904
nsv1032558 CNV loss 25217958

Variation tolerance for SLC36A3 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC36A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC36A3 Gene

Disorders for SLC36A3 Gene

Relevant External Links for SLC36A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC36A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC36A3 Gene

Publications for SLC36A3 Gene

  1. A cluster of proton/amino acid transporter genes in the human and mouse genomes. (PMID: 12809675) Boll M. … Daniel H. (Genomics 2003) 2 3 4 65
  2. Organization and expression of the SLC36 cluster of amino acid transporter genes. (PMID: 15058382) Bermingham J.R. Jr. … Pennington J. (Mamm. Genome 2004) 3 4 65
  3. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. (PMID: 23506890) SchiAPth H.B. … Fredriksson R. (Mol. Aspects Med. 2013) 3 65
  4. Mechanisms of lysophosphatidic acid (LPA) mediated stimulation of intestinal apical Cl-/OH- exchange. (PMID: 19910524) Singla A. … Dudeja P.K. (Am. J. Physiol. Gastrointest. Liver Physiol. 2010) 3 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 65

Products for SLC36A3 Gene

Sources for SLC36A3 Gene

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