SLC36A3 Gene
protein-coding GIFtS: 41
GCID: GC05M150636
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solute carrier family 36 (proton/amino acid symporter),...
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Aliases
for SLC36A3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 31 2 | | Proton-Coupled Amino Acid Transporter 32 | | PAT31 2 3 | | Solute Carrier Family 36, Member 32 | | TRAMD21 2 3 | | Tramdorin 22 | | Tramdorin21 | | Tramdorin-23 | | Proton/Amino Acid Transporter 32 3 | | Tramdorin-23 | | Solute Carrier Family 36 Member 32 3 | | |
Export aliases for SLC36A3 gene to outside databasesPrevious GC identifers: GC05M150647 GC05M150684 GC05M145801 |
Summaries
for SLC36A3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SLC36A3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC36A3 gene promoter:
E2F-4 E2F-3a E2F-5 SREBP-1c E2F-2 SREBP-1b E2F E2F-1 SREBP-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC36A3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC36A3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q33.1 Ensembl cytogenetic band: 5q33.1 HGNC cytogenetic band: 5q33.1SLC36A3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M150636: view genomic region
(about GC identifiers)
Start:
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150,655,926 bp from pter |
End:
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150,683,334 bp from pter |
Size:
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27,409 bases |
Orientation:
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minus strand |
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Proteins
for SLC36A3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S36A3_HUMAN, Q495N2 (See
protein sequence)Recommended Name: Proton-coupled amino acid transporter 3 Size: 470 amino acids; 51735 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q495N3 Q6ZMU7 Q6ZRU4 Q7Z6B4Alternative splicing: 3 isoforms: Q495N2-1 Q495N2-2 Q495N2-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC36A3: NX_Q495N2
Post-translational modifications:
Isoform 3 is phosphorylated on Tyr-1751
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q495N2
SLC36A3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001138489.1 NP_861439.3
ENSEMBL proteins: ENSP00000334750 ENSP00000366942
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC36A3 for ontologies About GeneDecksing
SLC36A3 Antibody Products:
Assay Products for SLC36A3: |
Protein
Domains /
Families
for SLC36A3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC36A3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q495N2ProtoNet protein and cluster: Q495N2 UniProtKB/Swiss-Prot: S36A3_HUMAN, Q495N2Similarity: Belongs to the amino acid/polyamine transporter 2 family |
Function
for SLC36A3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC36A3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC36A3 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC36A3 |
1 GenomeRNAi human phenotype for SLC36A3:
Animal Models:
1 MGI phenotypic allele  for Slc36a3 (no phenotypes)
SLC36A3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SLC36A3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC36A3
|
Drugs & Compounds
for SLC36A3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC36A3
Search CenterWatch for drugs/clinical trials and news about SLC36A3 / S36A3
|
Transcripts
for SLC36A3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC36A3 gene (2 alternative transcripts): NM_001145017.1 NM_181774.3 Unigene Cluster for SLC36A3: Solute carrier family 36 (proton/amino acid symporter), member 3 Hs.720893 [show with all ESTs]Unigene Representative Sequence: AK1314833 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000335230(uc003ltx.2 uc003ltw.2) ENST00000423071(uc003ltv.2)
ENST00000377713
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC36A3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC36A3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SLC36A3 (NM_181774) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC36A3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC36A3 |
Additional cDNA sequence: AK127978.1 AK131483.1 AY162215.1 AY228365.1 BC101092.1 BC101093.1 BC101094.1 BC101095.2 4 DOTS entries: DT.75136924 DT.120829018 DT.102820138 DT.104256 11 AceView cDNA sequences: BX090177 AA417270 AY162215 AK131483 AY228365 NM_181774 AK127978 AI208756 BG196868 AA417280 AA922218
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC36A3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC36A3
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Expression
for SLC36A3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC36A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGATGTTAT
About this image
See SLC36A3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.720893
UniProtKB/Swiss-Prot: S36A3_HUMAN, Q495N2Tissue specificity: Specifically expressed in testis
SABiosciences Custom PCR Arrays for SLC36A3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC36A3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC36A3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC36A3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC36A3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC36A3 |
Orthologs
for SLC36A3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC36A3 gene from 7/24 species (see all 24) About this table
ENSEMBL Gene Tree for SLC36A3 (if available)
TreeFam Gene Tree for SLC36A3 (if available) |
Paralogs
for SLC36A3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC36A3 gene
- SLC36A42 SLC36A12 SLC36A22
3 SIMAP similar genes for SLC36A3 using alignment to 1 protein entry: S36A3_HUMAN:SLC36A1 SLC36A2 SLC36A4
SLC36A3 for paralogs About GeneDecksing
|
Genomic Variants
for SLC36A3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC36A3 (150655926 - 150683334 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC36A3
1 CNV: 62443 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC36A3 |
|
Disorders
/ Diseases
for SLC36A3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SLC36A3 for disorders About MalaCards
SLC36A3 for disorders About GeneDecksing
OMIM gene information: 608332
OMIM disorders: --
Export disorders for SLC36A3 gene to outside databases
|
Publications
for SLC36A3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC36A3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC36A3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A cluster of proton/amino acid transporter genes in the human and mouse genomes. (PubMed id 12809675)1, 2, 3 Boll M.... Daniel H. (2003)
- Organization and expression of the SLC36 cluster of amino acid transporter genes. (PubMed id 15058382)1, 2 Bermingham J.R. Jr. and Pennington J. (2004)
- Mechanisms of lysophosphatidic acid (LPA) mediated st imulation of intestinal apical Cl-/OH- exchange. (PubMed id 19910524)1 Singla A....Dudeja P.K. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC36A3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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|
Genome Databases showing SLC36A3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC36A3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC36A3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC36A3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLC36A3 gene:
Search GeneIP for patents involving SLC36A3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC36A3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | SLC36A3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC36A3 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC36A3 |
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