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SLC36A2 Gene

protein-coding   GIFtS: 51
GCID: GC05M150674

Solute Carrier Family 36 (Proton/Amino Acid Symporter),...

  See SLC36A2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 21 2     tramdorin-12
PAT22 3 5     Tramdorin-13
TRAMD12 3     Proton/Amino Acid Transporter 23
Proton-Coupled Amino Acid Transporter 22     Solute Carrier Family 36 Member 23

External Ids:    HGNC: 187621   Entrez Gene: 1532012   Ensembl: ENSG000001863357   OMIM: 6083315   UniProtKB: Q495M33   

Export aliases for SLC36A2 gene to outside databases

Previous GC identifers: GC05M151309 GC05M150695 GC05M150723 GC05M145839


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC36A2 Gene:
This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin
permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine
and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria. (provided by RefSeq,
Sep 2010)

GeneCards Summary for SLC36A2 Gene:
SLC36A2 (solute carrier family 36 (proton/amino acid symporter), member 2) is a protein-coding gene. Diseases associated with SLC36A2 include iminoglycinuria, and hyperglycinuria. GO annotations related to this gene include L-alanine transmembrane transporter activity and L-proline transmembrane transporter activity. An important paralog of this gene is SLC36A4.

UniProtKB/Swiss-Prot: S36A2_HUMAN, Q495M3
Function: Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids.
Transports glycine and proline. Inhibited by sarcosine (By similarity)

Gene Wiki entry for SLC36A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC36A2 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   RelA   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC36A2 promoter sequence
   Search Chromatin IP Primers for SLC36A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC36A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q33.1

SLC36A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC36A2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M150674:  view genomic region     (about GC identifiers)

Start:
150,694,539 bp from pter      End:
150,727,151 bp from pter
Size:
32,613 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S36A2_HUMAN, Q495M3 (See protein sequence)
Recommended Name: Proton-coupled amino acid transporter 2  
Size: 483 amino acids; 53216 Da
Secondary accessions: Q495M4 Q495M6 Q6ZWK5 Q7Z6B5
Alternative splicing: 3 isoforms:  Q495M3-1   Q495M3-2   Q495M3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC36A2: NX_Q495M3

Explore proteomics data for SLC36A2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC36A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_861441.2  
    ENSEMBL proteins: 
     ENSP00000334223   ENSP00000430149   ENSP00000428453   ENSP00000430535   ENSP00000428634  
     ENSP00000399479  
    Reactome Protein details: Q495M3

    SLC36A2 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for SLC36A2 (4 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Proton-coupled Amino acid Transporter 2
    SLC36 family of proton-coupled amino acid transporters

    1 InterPro protein domain:
     IPR013057 AA_transpt_TM

    Graphical View of Domain Structure for InterPro Entry Q495M3

    ProtoNet protein and cluster: Q495M3

    UniProtKB/Swiss-Prot: S36A2_HUMAN, Q495M3
    Similarity: Belongs to the amino acid/polyamine transporter 2 family


    Find genes that share domains with SLC36A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S36A2_HUMAN, Q495M3
    Function: Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids.
    Transports glycine and proline. Inhibited by sarcosine (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005280hydrogen:amino acid symporter activity IEA--
    GO:0015180L-alanine transmembrane transporter activity IEA--
    GO:0015187glycine transmembrane transporter activity IMP19033659
    GO:0015193L-proline transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC36A2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC36A2

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC36A2 (see all 9):
    hsa-miR-130a* hsa-miR-3614-3p hsa-miR-23c hsa-miR-450b-3p hsa-miR-153 hsa-miR-23b hsa-miR-518a-5p hsa-miR-3919
    SwitchGear 3'UTR luciferase reporter plasmidSLC36A2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S36A2_HUMAN, Q495M3: Cell membrane; Multi-pass membrane protein. Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SLC36A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC36A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Amino acid transport across the plasma membrane0.32
    Transmembrane transport of small molecules0.47
    Proton-coupled neutral amino acid transporters0.00
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38


    Find genes that share SuperPaths with SLC36A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for SLC36A2
        Amino acid transport across the plasma membrane
    Proton-coupled neutral amino acid transporters


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC36A2
    Interactions:

        Search GeneGlobe Interaction Network for SLC36A2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SLC36A2 (ENSP000003342234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP6CENSP000003921474STRING: ENSP00000392147
    PPP2CAENSP000004184474STRING: ENSP00000418447
    PPP2CBENSP000002211384STRING: ENSP00000221138
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006865amino acid transport TAS--
    GO:0015808L-alanine transport ----
    GO:0015816glycine transport ----
    GO:0015824proline transport ----

    Find genes that share ontologies with SLC36A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC36A2 (S36A2)

    1 HMDB Compound for SLC36A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Sarcosine(Methylamino)acetate (see all 15)107-97-1--

    2 IUPHAR Ligands for SLC36A2 (Proton-coupled Amino acid Transporter 2)    About this table
    LigandTypeActionAffinityPubmed IDs
    5-hydroxy-L-tryptophan
    InhibitorInhibition2.820691150
    alpha-methyl-D,L-tryptophan
    InhibitorInhibition2.520691150



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC36A2 gene: 
    NM_181776.2  

    Unigene Cluster for SLC36A2:

    Solute carrier family 36 (proton/amino acid symporter), member 2
    Hs.483877  [show with all ESTs]
    Unigene Representative Sequence: NM_181776
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335244(uc003lty.3 uc003ltz.3 uc003lua.3) ENST00000518617
    ENST00000518280 ENST00000521967(uc010jhv.2) ENST00000523044 ENST00000522829(uc011dct.1)
    ENST00000450886
    miRNA
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    hsa-miR-130a* hsa-miR-3614-3p hsa-miR-23c hsa-miR-450b-3p hsa-miR-153 hsa-miR-23b hsa-miR-518a-5p hsa-miR-3919
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC36A2
      QuantiFast Probe-based Assays in human, mouse, rat SLC36A2

    Additional mRNA sequence: 

    AK297682.1 AK309575.1 AY162214.1 AY228364.1 BC101100.1 BC101101.1 BC101102.1 BC101103.2 
    BX538285.1 

    4 DOTS entries:

    DT.40126004  DT.101986557  DT.101959407  DT.92042453 

    11 AceView cDNA sequences:

    AI795927 BX499866 BX538285 BE501426 AY228364 BX098462 AI796518 BF511146 
    AK122630 BF510558 AI795937 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC36A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAACATAA
    SLC36A2 Expression
    About this image


    SLC36A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Kidney (Urinary System)
             Proximal Tubule Cells Proximal Tubule
     
     Epithelial Cells
             Proximal Tubule Cells Proximal Tubule
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Periosteum
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
    SLC36A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC36A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.483877

    UniProtKB/Swiss-Prot: S36A2_HUMAN, Q495M3
    Tissue specificity: Abundantly expressed in kidney and muscle. Expressed in the S1 segment of the proximal tubule
    close to the glomerulus

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC36A2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc36a21 , 5 solute carrier family 36 (proton/amino acid symporter), more1, 5 84.52(n)1
    82.43(a)1
      11 (32.16 cM)5
    2460491  NM_153170.31  NP_694810.21 
     551584705 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    60(a)
    1 → many
    13(12316354-12329185)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    62(a)
    1 → many
    2(137841084-137944473)
    zebrafish
    (Danio rerio)
    Actinopterygii slc36a16
    solute carrier family 36 (proton/amino acid sympor...
    57(a)
    1 → many
    14(26996448-27076585) ENSDARG00000075618
    fruit fly
    (Drosophila melanogaster)
    Insecta CG133846
    CG11396
    (see all 11)
    --
    36(a)
    33(a)
    (see all 11)
    many ↔ many
    many ↔ many
    (see all 11)
    2L(8384455-8388804)
    3L(1971638-1974285)
    worm
    (Caenorhabditis elegans)
    Secernentea T27A1.56
    Y43F4B.76
    (see all 6)
    Protein Y43F4B.7 (Y43F4B.7) mRNA, complete cds
    (see all 6)
    32(a)
    31(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    II(522594-525975) WBGene00020837
    III(13307502-13313393) WBGene00012804
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AVT46
    AVT36
    Vacuolar transporter, exports large neutral amino ...
    Vacuolar transporter, exports large neutral amino ...
    17(a)
    17(a)
    many ↔ many
    many ↔ many
    XIV(434999-437140) YNL101W
    XI(171783-173861) YKL146W


    ENSEMBL Gene Tree for SLC36A2 (if available)
    TreeFam Gene Tree for SLC36A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC36A2 gene
    SLC36A42  SLC36A12  SLC36A32  
    3 SIMAP similar genes for SLC36A2 using alignment to 4 protein entries:     S36A2_HUMAN (see all proteins):
    SLC36A1    SLC36A3    SLC36A4

    Find genes that share paralogs with SLC36A2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SLC36A2
    PGOHUM00000235427


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC36A2 (see all 913)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs770103151,2,,4
    C,FIminoglycinuria (IG)4 pathogenic1150999363(+) GTGGGC/ACCATC 2 /G /V mis12Minor allele frequency- A:0.01NA EU 5875
    rs776627021,2
    C--145845091(+) TTTTTC/TCCCTG 1 -- int10--------
    rs106822701,2
    C--145845352(+) AAAAA-/AA/AAA
            
    GAATT
    2 -- int1 cds1 trp30--------
    rs1385764161,2
    C--145848207(+) GATAG-/ATA   
       AATAA
    ATAAA
    1 -- int10--------
    rs2000715311,2
    --145848239(+) AATAA-/ATGG  
            
    GTGTG
    1 -- int10--------
    rs3682434581,2
    C--145849258(+) CTGGC-/TTAT  
            
    TTATT
    1 -- int10--------
    rs1133176501,2
    C--145864274(+) CGTTCT/-TTTTT 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs106817751,2
    C--150695031(+) gaaaa-/AATacaaa 1 -- cds10--------
    rs105252501,2
    C--150695032(+) AAAAA-/AA    
       T
    /ATA
    CAAAA
    2 -- cds11NA 2
    rs40357981,2
    C--150698084(+) TATAAATAA/-  
            
    TAATT
    1 -- int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for SLC36A2 (150694539 - 150727151 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC36A2: --
    Human Gene Mutation Database (HGMD): SLC36A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC36A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC36A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608331   
    OMIM disorders: 242600  138500  
    UniProtKB/Swiss-Prot: S36A2_HUMAN, Q495M3
  • Hyperglycinuria (HG) [MIM:138500]: A condition characterized by excess of glycine in the urine. In some
    cases it is associated with renal colic and renal oxalate stones. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Iminoglycinuria (IG) [MIM:242600]: A disorder of renal tubular reabsorption of glycine and imino acids
    (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. Note=The disease
    is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Mutations
    in SLC36A2 that retain residual transport activity result in the IG phenotype only when combined with
    haploinsufficiency of the imino acid transporter SLC6A20 or deficiency of the neutral amino acid transporter
    SLC6A19. Additional polymorphisms and mutations in SLC6A18 can contribute to iminoglycinuria in some families

  • 3 diseases for SLC36A2:    
    About MalaCards
    iminoglycinuria    hyperglycinuria    iminoglycinuria, digenic


    Find genes that share disorders with SLC36A2           About GenesLikeMe

    Genetic Association Database (GAD): SLC36A2
    Human Genome Epidemiology (HuGE) Navigator: SLC36A2 (3 documents)

    Export disorders for SLC36A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC36A2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with SLC36A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters. (PubMed id 19033659)1, 2, 9 Broer S.... Rasko J.E. (J. Clin. Invest. 2008)
    2. Organization and expression of the SLC36 cluster of amino acid transporter genes. (PubMed id 15058382)1, 2, 9 Bermingham J.R. Jr. and Pennington J. (Mamm. Genome 2004)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PubMed id 19845895)1, 4 Koskinen L.L....Saavalainen P. (Tissue Antigens 2009)
    5. A cluster of proton/amino acid transporter genes in the human and mouse genomes. (PubMed id 12809675)1, 2 Boll M.... Daniel H. (Genomics 2003)
    6. Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters. (PubMed id 11959859)1, 3 Boll M....Daniel H. (J. Biol. Chem. 2002)
    7. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    8. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    9. Amino acid transport across mammalian intestinal and renal epithelia. (PubMed id 18195088)1 BrAPer S. (Physiol. Rev. 2008)
    10. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 153201 HGNC: 18762 AceView: SLC36A2.1 Ensembl:ENSG00000186335 euGenes: HUgn153201
    ECgene: SLC36A2 H-InvDB: SLC36A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC36A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC36A2 gene:
    Search GeneIP for patents involving SLC36A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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