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Aliases for SLC36A1 Gene

Aliases for SLC36A1 Gene

  • Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 1 2 3
  • PAT1 3 4 6
  • Solute Carrier Family 36 Member 1 3 4
  • Proton/Amino Acid Transporter 1 3 4
  • LYAAT1 3 6
  • HPAT1 3 4
  • Proton-Coupled Amino Acid Transporter 1 3
  • Lysosomal Amino Acid Transporter 1 3
  • TRAMD3 3
  • Dct1 3

External Ids for SLC36A1 Gene

Previous GeneCards Identifiers for SLC36A1 Gene

  • GC05P150799
  • GC05P150845
  • GC05P150855
  • GC05P150807
  • GC05P145972

Summaries for SLC36A1 Gene

Entrez Gene Summary for SLC36A1 Gene

  • This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC36A1 Gene

SLC36A1 (Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 1) is a Protein Coding gene. Diseases associated with SLC36A1 include allan-herndon-dudley syndrome and aminoaciduria. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Protein digestion and absorption. GO annotations related to this gene include symporter activity and L-alanine transmembrane transporter activity. An important paralog of this gene is SLC36A3.

UniProtKB/Swiss-Prot for SLC36A1 Gene

  • Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity).

Gene Wiki entry for SLC36A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC36A1 Gene

Genomics for SLC36A1 Gene

Regulatory Elements for SLC36A1 Gene

Genomic Location for SLC36A1 Gene

Start:
151,436,992 bp from pter
End:
151,517,446 bp from pter
Size:
80,455 bases
Orientation:
Plus strand

Genomic View for SLC36A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC36A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC36A1 Gene

Proteins for SLC36A1 Gene

  • Protein details for SLC36A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2H8-S36A1_HUMAN
    Recommended name:
    Proton-coupled amino acid transporter 1
    Protein Accession:
    Q7Z2H8
    Secondary Accessions:
    • C9JI34
    • Q1LZ56
    • Q7Z7C0
    • Q86YK4
    • Q96M74

    Protein attributes for SLC36A1 Gene

    Size:
    476 amino acids
    Molecular mass:
    53076 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71435.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC36A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC36A1 Gene

Proteomics data for SLC36A1 Gene at MOPED

Post-translational modifications for SLC36A1 Gene

  • Glycosylation at Asn174, Asn183, and Asn470
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC36A1 Gene

No data available for DME Specific Peptides for SLC36A1 Gene

Domains for SLC36A1 Gene

Gene Families for SLC36A1 Gene

Protein Domains for SLC36A1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z2H8

UniProtKB/Swiss-Prot:

S36A1_HUMAN :
  • Q7Z2H8
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC36A1: view

Function for SLC36A1 Gene

Molecular function for SLC36A1 Gene

UniProtKB/Swiss-Prot Function:
Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity).

Gene Ontology (GO) - Molecular Function for SLC36A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005280 hydrogen:amino acid symporter activity IBA --
GO:0015078 hydrogen ion transmembrane transporter activity IBA --
GO:0015180 L-alanine transmembrane transporter activity IBA --
GO:0015187 glycine transmembrane transporter activity IBA --
GO:0015193 L-proline transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC36A1: view

Phenotypes for SLC36A1 Gene

GenomeRNAi human phenotypes for SLC36A1:
genes like me logo Genes that share phenotypes with SLC36A1: view

Animal Model Products

CRISPR Products

miRNA for SLC36A1 Gene

miRTarBase miRNAs that target SLC36A1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC36A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC36A1 Gene

Localization for SLC36A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC36A1 Gene

Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC36A1 Gene COMPARTMENTS Subcellular localization image for SLC36A1 gene
Compartment Confidence
lysosome 5
plasma membrane 5
vacuole 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for SLC36A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005783 endoplasmic reticulum IDA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC36A1: view

Pathways for SLC36A1 Gene

genes like me logo Genes that share pathways with SLC36A1: view

Interacting Proteins for SLC36A1 Gene

Gene Ontology (GO) - Biological Process for SLC36A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006865 amino acid transport TAS --
GO:0015804 neutral amino acid transport --
GO:0015808 L-alanine transport IBA --
GO:0015816 glycine transport IBA --
genes like me logo Genes that share ontologies with SLC36A1: view

Compounds for SLC36A1 Gene

(7) Drugbank Compounds for SLC36A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acamprosate
  • 3-(Acetylamino)propanesulphonic acid
77337-76-9 transporter
D-Proline
344-25-2 transporter
Glycine
  • 2-Aminoacetic acid
56-40-6 target
Hydroxyproline
  • L-Hydroxyproline
51-35-4 transporter
L-Alanine
  • (2S)-2-Aminopropanoic acid
56-41-7 target

(4) IUPHAR Ligand for SLC36A1 Gene

Ligand Type Action Affinity Pubmed IDs
5-hydroxy-L-tryptophan Inhibitor Inhibition 2.8
L-tryptophan Inhibitor Inhibition 2.3
indole-3-propionic acid Inhibitor Inhibition 2.3
5-HT Inhibitor Inhibition 2.2

(13) Novoseek inferred chemical compound relationships for SLC36A1 Gene

Compound -log(P) Hits PubMed IDs
pat-2 93.7 4
alpha-(methylamino)-isobutyric acid 81.3 1
beta-alanine 73.2 3
imino 72.9 4
proline 61.8 7
genes like me logo Genes that share compounds with SLC36A1: view

Transcripts for SLC36A1 Gene

Unigene Clusters for SLC36A1 Gene

Solute carrier family 36 (proton/amino acid symporter), member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC36A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC36A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - - - - - -
SP2:
SP3: - - - - - -
SP4:
SP5: - - - - - -
SP6:
SP7: - -
SP8:

Relevant External Links for SLC36A1 Gene

GeneLoc Exon Structure for
SLC36A1
ECgene alternative splicing isoforms for
SLC36A1

Expression for SLC36A1 Gene

mRNA expression in normal human tissues for SLC36A1 Gene

mRNA differential expression in normal tissues according to GTEx for SLC36A1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (5.3), Brain - Cerebellum (5.0), and Whole Blood (4.7).

Protein differential expression in normal tissues for SLC36A1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC36A1 Gene

SOURCE GeneReport for Unigene cluster for SLC36A1 Gene Hs.269004

genes like me logo Genes that share expressions with SLC36A1: view

Expression partners for SLC36A1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SLC36A1 Gene

Orthologs for SLC36A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC36A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC36A1 35
  • 88.24 (n)
  • 89.29 (a)
SLC36A1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC36A1 35
  • 90.69 (n)
  • 93.7 (a)
SLC36A1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc36a1 35
  • 85.68 (n)
  • 86.11 (a)
Slc36a1 16
Slc36a1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC36A1 35
  • 99.72 (n)
  • 99.79 (a)
SLC36A1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc36a1 35
  • 84.56 (n)
  • 85.89 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC36A1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC36A1 35
  • 75.31 (n)
  • 75.16 (a)
-- 36
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc36a1 35
  • 66.26 (n)
  • 66.26 (a)
zebrafish
(Danio rerio)
Actinopterygii slc36a1 35
  • 64.19 (n)
  • 64.49 (a)
slc36a1 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1139 36
  • 35 (a)
ManyToMany
CG12943 36
  • 26 (a)
ManyToMany
CG13384 36
  • 38 (a)
ManyToMany
CG16700 36
  • 33 (a)
ManyToMany
CG32079 36
  • 29 (a)
ManyToMany
CG32081 36
  • 26 (a)
ManyToMany
CG43693 36
  • 27 (a)
ManyToMany
CG4991 36
  • 29 (a)
ManyToMany
CG7888 36
  • 33 (a)
ManyToMany
CG8785 36
  • 31 (a)
ManyToMany
path 36
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C44B7.6 36
  • 26 (a)
ManyToMany
F59B2.2 36
  • 23 (a)
ManyToMany
H32K16.1 36
  • 26 (a)
ManyToMany
T27A1.5 36
  • 32 (a)
ManyToMany
Y38H6C.17 36
  • 25 (a)
ManyToMany
Y43F4B.7 36
  • 32 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR051C 35
  • 44.68 (n)
  • 34.05 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13795g 35
  • 42.56 (n)
  • 30.11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT3 35
  • 43.07 (n)
  • 32.18 (a)
AVT3 36
  • 15 (a)
ManyToMany
AVT4 36
  • 18 (a)
ManyToMany
AVT4 38
bread mold
(Neurospora crassa)
Ascomycetes NCU03783 35
  • 47.3 (n)
  • 30.15 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes avt3 35
  • 41.51 (n)
  • 32.64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for SLC36A1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC36A1 Gene

ENSEMBL:
Gene Tree for SLC36A1 (if available)
TreeFam:
Gene Tree for SLC36A1 (if available)

Paralogs for SLC36A1 Gene

Paralogs for SLC36A1 Gene

Selected SIMAP similar genes for SLC36A1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SLC36A1: view

Variants for SLC36A1 Gene

Sequence variations from dbSNP and Humsavar for SLC36A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1175 -- 151,492,234(+) TGTTA(C/T)GTGCC utr-variant-3-prime, intron-variant
rs14160 -- 151,491,719(-) CCAGC(A/G)GGGGC utr-variant-3-prime, intron-variant
rs151755 -- 151,486,297(+) cccac(A/G)actca intron-variant
rs152389 -- 151,482,619(-) TAAAA(C/T)TAAAT intron-variant
rs152390 -- 151,482,954(-) gttca(C/T)gccat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC36A1 Gene

Variant ID Type Subtype PubMed ID
nsv883033 CNV Gain 21882294
nsv823322 CNV Gain 20364138

Relevant External Links for SLC36A1 Gene

HapMap Linkage Disequilibrium report
SLC36A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC36A1 Gene

Disorders for SLC36A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC36A1 Gene in MalaCards »

(2) Diseases for SLC36A1 Gene including...

(2) University of Copenhagen DISEASES for SLC36A1 Gene

(2) Novoseek inferred disease relationships for SLC36A1 Gene

Disease -log(P) Hits PubMed IDs
iminoglycinuria 92 1
adenoma 37 3
genes like me logo Genes that share disorders with SLC36A1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for SLC36A1 Gene

Publications for SLC36A1 Gene

  1. A cluster of proton/amino acid transporter genes in the human and mouse genomes. (PMID: 12809675) Boll M. … Daniel H. (Genomics 2003) 3 4 23
  2. Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2. (PMID: 12527723) Chen Z. … Ganapathy V. (J. Physiol. (Lond.) 2003) 3 4 23
  3. Identification of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1. (PMID: 19549785) Dorn M. … Bosse-Doenecke E. (J. Biol. Chem. 2009) 3 4 23
  4. Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+ -coupled amino-acid transporter hPAT1. (PMID: 16331283) Abbot E.L. … Thwaites D.T. (Br. J. Pharmacol. 2006) 3 23 25
  5. Organization and expression of the SLC36 cluster of amino acid transporter genes. (PMID: 15058382) Bermingham J.R. Jr. … Pennington J. (Mamm. Genome 2004) 3 4 25

Products for SLC36A1 Gene

Sources for SLC36A1 Gene

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