Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC36A1 Gene

protein-coding   GIFtS: 56
GCID: GC05P150807

Solute Carrier Family 36 (Proton/Amino Acid Symporter),...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 11 2     LYAAT12 5
PAT12 3 5     Dct12
Proton/Amino Acid Transporter 12 3     TRAMD32
Solute Carrier Family 36 Member 12 3     Lysosomal Amino Acid Transporter 12
hPAT12 3     Proton-Coupled Amino Acid Transporter 12

External Ids:    HGNC: 187611   Entrez Gene: 2063582   Ensembl: ENSG000001236437   OMIM: 6065615   UniProtKB: Q7Z2H83   

Export aliases for SLC36A1 gene to outside databases

Previous GC identifers: GC05P151413 GC05P150799 GC05P150845 GC05P150855 GC05P145972


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC36A1 Gene:
This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The
encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with
related family members on chromosome 5q33.1. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC36A1 Gene:
SLC36A1 (solute carrier family 36 (proton/amino acid symporter), member 1) is a protein-coding gene. Diseases associated with SLC36A1 include iminoglycinuria, and hartnup disease. GO annotations related to this gene include L-alanine transmembrane transporter activity and symporter activity. An important paralog of this gene is SLC36A4.

UniProtKB/Swiss-Prot: S36A1_HUMAN, Q7Z2H8
Function: Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino
acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their
D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity)

Gene Wiki entry for SLC36A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC36A1 gene promoter:
         Max1   USF1   AML1a   Pax-2   Pax-2a   Arnt   C/EBPalpha   Max   USF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC36A1 promoter sequence
   Search Chromatin IP Primers for SLC36A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC36A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q33.1

SLC36A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC36A1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P150807:  view genomic region     (about GC identifiers)

Start:
150,816,607 bp from pter      End:
150,871,942 bp from pter
Size:
55,336 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: S36A1_HUMAN, Q7Z2H8 (See protein sequence)
Recommended Name: Proton-coupled amino acid transporter 1  
Size: 476 amino acids; 53076 Da
Sequence caution: Sequence=BAB71435.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: C9JI34 Q1LZ56 Q7Z7C0 Q86YK4 Q96M74
Alternative splicing: 3 isoforms:  Q7Z2H8-1   Q7Z2H8-3   Q7Z2H8-4   

Explore the universe of human proteins at neXtProt for SLC36A1: NX_Q7Z2H8

Explore proteomics data for SLC36A1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn174, Asn183, Asn470

  • See SLC36A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_510968.2  
    ENSEMBL proteins: 
     ENSP00000429796   ENSP00000428140   ENSP00000395640   ENSP00000243389   ENSP00000427804  
     ENSP00000430305   ENSP00000428471   ENSP00000428738   ENSP00000430181  
    Reactome Protein details: Q7Z2H8

    SLC36A1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC36A1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC36A1
    GenScript Custom Purified and Recombinant Proteins Services for SLC36A1
    Novus Biologicals SLC36A1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SLC36A1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SLC36A1
    OriGene Custom Antibody Services for SLC36A1
    Novus Biologicals SLC36A1 Antibodies
    Abcam antibodies for SLC36A1
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SLC36A1
    LSBio Antibodies in human, mouse, rat for SLC36A1

    SLC36A1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC36A1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC36A1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Proton-coupled Amino acid Transporter 1
    SLC36 family of proton-coupled amino acid transporters

    1 InterPro protein domain:
     IPR013057 AA_transpt_TM

    Graphical View of Domain Structure for InterPro Entry Q7Z2H8

    ProtoNet protein and cluster: Q7Z2H8

    UniProtKB/Swiss-Prot: S36A1_HUMAN, Q7Z2H8
    Similarity: Belongs to the amino acid/polyamine transporter 2 family


    SLC36A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S36A1_HUMAN, Q7Z2H8
    Function: Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino
    acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their
    D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015078hydrogen ion transmembrane transporter activity IEA--
    GO:0015180L-alanine transmembrane transporter activity IEA--
    GO:0015187glycine transmembrane transporter activity IEA--
    GO:0015193L-proline transmembrane transporter activity IEA--
    GO:0015293symporter activity IEA--
         
    SLC36A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC36A1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC36A1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC36A1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC36A1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC36A1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC36A1:
    hsa-mir-18a-5p (MIRT031320), hsa-mir-500a-5p (MIRT037999)

    Block miRNA regulation of human, mouse, rat SLC36A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC36A1 (see all 53):
    hsa-miR-579 hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-15a hsa-miR-106a hsa-miR-29a hsa-miR-765 hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC36A1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC36A1
    Predesigned siRNA for gene silencing in human, mouse, rat SLC36A1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC36A1

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC36A1 (see all 6)
    OriGene ORF clones in mouse, rat for SLC36A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC36A1 (NM_078483)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC36A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC36A1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC36A1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC36A1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC36A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    S36A1_HUMAN, Q7Z2H8: Cell membrane; Multi-pass membrane protein (By similarity). Lysosome membrane; Multi-pass
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    plasma membrane5
    vacuole5
    endoplasmic reticulum4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome ----
    GO:0005765lysosomal membrane IDA17897319
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    SLC36A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC36A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Amino acid transport across the plasma membrane0.32
    Transmembrane transport of small molecules0.47
    Proton-coupled neutral amino acid transporters0.00
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    2Protein digestion and absorption
    Protein digestion and absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for SLC36A1
        Amino acid transport across the plasma membrane
    Proton-coupled neutral amino acid transporters


    1 Kegg Pathway  (Kegg details for SLC36A1):
        Protein digestion and absorption


    SLC36A1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC36A1
    Interactions:

        GeneGlobe Interaction Network for SLC36A1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for SLC36A1 (Q7Z2H83 ENSP000002433894) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP6CO007433, ENSP000003921474I2D: score=4 STRING: ENSP00000392147
    CSNK1G2P783683I2D: score=2 
    PAK3O759143I2D: score=2 
    ACACBO007633I2D: score=1 
    CCT2P783713I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006865amino acid transport TAS--
    GO:0015804neutral amino acid transport ----
    GO:0015808L-alanine transport ----
    GO:0015816glycine transport ----

    SLC36A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC36A1 (S36A1)

    7 DrugBank Compounds for SLC36A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glycine2-Aminoacetic acid (see all 4)56-40-6target--16052352 15058382 14718599 17139284 17016423
    L-Alanine(2S)-2-Aminopropanoic acid (see all 15)56-41-7target--16373326 17139284 17016423
    Acamprosate3-(Acetylamino)propanesulphonic acid (see all 4)77337-76-9transporter--10711343
    D-Proline-- 344-25-2transporter--14718599
    HydroxyprolineL-Hydroxyproline (see all 2)51-35-4transporter--14718599
    Spaglumic AcidN-(N-Acetyl-l-β-aspartyl)-l-glutamic acid (see all 4)4910-46-7transportersubstrate Other16627568
    Vigabatringamma-Vinyl GABA (see all 7)60643-86-9transporter--16331283

    4 IUPHAR Ligands for SLC36A1 (Proton-coupled Amino acid Transporter 1)    About this table
    LigandTypeActionAffinityPubmed IDs
    5-hydroxy-L-tryptophan
    InhibitorInhibition316126914
    L-tryptophan
    InhibitorInhibition2.316126914
    indole-3-propionic acid
    InhibitorInhibition2.316126914
    5-HT
    InhibitorInhibition2.216126914

    Selected Novoseek inferred chemical compound relationships for SLC36A1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pat-2 93.7 5 12809675 (2), 15291811 (1), 12748860 (1)
    alpha-(methylamino)-isobutyric acid 81.3 1 16373326 (1)
    beta-alanine 73.2 7 15754324 (1), 17498647 (1), 19074966 (1)
    imino 72.9 5 16373326 (2), 15521011 (1), 16052352 (1)
    proline 61.8 8 16373326 (3), 16052352 (1), 18621125 (1), 16531028 (1) (see all 5)
    gaba 42.5 2 18621125 (1), 16531028 (1)
    oxalate 40.2 2 15956810 (1), 15203903 (1)
    serine 37.5 3 15754324 (1), 12893527 (1), 16531028 (1)
    hydroxyproline 37 3 16373326 (1), 16531028 (1)
    alanine 36.4 2 12748860 (1), 16373326 (1)



    SLC36A1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC36A1 gene: 
    NM_078483.2  

    Unigene Cluster for SLC36A1:

    Solute carrier family 36 (proton/amino acid symporter), member 1
    Hs.269004  [show with all ESTs]
    Unigene Representative Sequence: BX537963
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520111 ENST00000520701(uc003lub.1) ENST00000429484 ENST00000243389(uc003luc.3)
    ENST00000517945 ENST00000521925(uc010jhw.1) ENST00000521351 ENST00000519829
    ENST00000517628 ENST00000522185
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC36A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC36A1 (see all 53):
    hsa-miR-579 hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-15a hsa-miR-106a hsa-miR-29a hsa-miR-765 hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC36A1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC36A1
    Predesigned siRNA for gene silencing in human, mouse, rat SLC36A1
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC36A1 (see all 6)
    OriGene ORF clones in mouse, rat for SLC36A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC36A1 (NM_078483)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC36A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC36A1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC36A1
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC36A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC36A1
      QuantiTect SYBR Green Assays in human, mouse, rat SLC36A1
      QuantiFast Probe-based Assays in human, mouse, rat SLC36A1

    Additional mRNA sequence: 

    AF010235.1 AF516142.1 AK000729.1 AK025102.1 AK057340.1 AK309323.1 AL833703.1 AY162213.1 
    AY227111.1 AY227112.1 AY227113.1 BC136437.1 BC136438.1 BX537963.1 GU296670.1 

    6 DOTS entries:

    DT.413162  DT.100751411  DT.75178465  DT.75157993  DT.120870047  DT.75164093 

    Selected AceView cDNA sequences (see all 96):

    AY227111 CA432126 Z38372 AL833703 AK025102 BQ772770 BF197975 W68120 
    NM_078483 AI932971 BM991766 AY227112 BG562543 AY227113 AY162213 AW471248 
    BU617471 AI140615 AI417980 BU735105 AI052057 CA391070 AI888489 BM791052 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC36A1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:              -     -     -     -     -     -     -                                                           -                                       
    SP2:                                                                                                                                                      
    SP3:                    -     -     -     -     -     -                                                                                                   
    SP4:                                                                                                                                                      
    SP5:              -     -     -     -     -     -                                                                                                         


    ECgene alternative splicing isoforms for SLC36A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC36A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC36A1 Expression
    About this image

    SLC36A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC36A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.269004
        Custom PCR Arrays for SLC36A1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC36A1
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC36A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC36A1
    QuantiTect SYBR Green Assays in human, mouse, rat SLC36A1
    QuantiFast Probe-based Assays in human, mouse, rat SLC36A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC36A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC36A1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc36a11 , 5 solute carrier family 36 (proton/amino acid symporter), more1, 5 85.68(n)1
    86.11(a)1
      11 (32.33 cM)5
    2153351  NM_153139.41  NP_694779.31 
     552043505 
    chicken
    (Gallus gallus)
    Aves SLC36A11 solute carrier family 36 (proton/amino acid symporter), more 75.31(n)
    75.16(a)
      770250  XM_004944938.1  XP_004944995.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    73(a)
    1 → many
    2(137841084-137944473)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc36a11 solute carrier family 36 (proton/amino acid symporter), more 66.26(n)
    66.26(a)
      100492769  XM_002932374.2  XP_002932420.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc36a11 solute carrier family 36 (proton/amino acid symporter), more 64.19(n)
    64.49(a)
      559308  XM_682640.5  XP_687732.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG133846
    CG11396
    (see all 11)
    --
    38(a)
    35(a)
    (see all 11)
    many ↔ many
    many ↔ many
    (see all 11)
    2L(8384455-8388804)
    3L(1971638-1974285)
    worm
    (Caenorhabditis elegans)
    Secernentea Y43F4B.76
    T27A1.56
    (see all 6)
    Protein T27A1.5, isoform a
    (see all 6)
    32(a)
    32(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    III(13307502-13313393) WBGene00012804
    II(522594-525975) WBGene00020837
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AVT4(YNL101W)4
    AVT31
    Vacuolar transporter, exports large neutral amino acids more4
    AVT31
    43.07(n)1
    32.18(a)1
      14(434999-437140)4
    8537101  NP_012776.11  8556224 
     NP_014298.14 


    ENSEMBL Gene Tree for SLC36A1 (if available)
    TreeFam Gene Tree for SLC36A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC36A1 gene
    SLC36A42  SLC36A32  SLC36A22  
    3 SIMAP similar genes for SLC36A1 using alignment to 8 protein entries:     S36A1_HUMAN (see all proteins):
    SLC36A2    SLC36A3    SLC36A4

    SLC36A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC36A1 (see all 1201)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381993751,2
    Cuntested1150844107(+) GGCATC/TGTGGC 2 I syn11Minor allele frequency- T:0.00NA 4552
    rs100677171,2
    C,F,A,H--150825197(+) agtcaG/Aatagt 1 -- us2k115Minor allele frequency- A:0.11NS EA NA WA 1762
    rs1502741881,2
    --150825237(+) TTATTA/GGTCTG 1 -- us2k10--------
    rs39059081,2
    C,F,H--150825329(+) caataT/Cgttgg 1 -- us2k123Minor allele frequency- C:0.23NS EA NA CSA WA 2217
    rs1848090851,2
    --150825432(+) TTCTTC/TTTTTT 1 -- us2k10--------
    rs1876198141,2
    --150825441(+) TTCTTA/TGACTA 1 -- us2k10--------
    rs1921033001,2
    --150825462(+) CGTCAA/TTTTAA 1 -- us2k10--------
    rs788356851,2
    C--150825554(+) CTCTTC/TCTTTT 1 -- us2k10--------
    rs727983121,2
    C,F--150825668(+) TTATTG/TCTATA 1 -- us2k12Minor allele frequency- T:0.29NA EA 240
    rs1850499481,2
    --150825676(+) ATAAAA/CTTCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC36A1 (150816607 - 150871942 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC36A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv823322CNV Gain20364138
    nsv883033CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC36A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC36A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606561    OMIM disorders: --

    8 diseases for SLC36A1:    
    About MalaCards
    iminoglycinuria    hartnup disease    allan-herndon-dudley syndrome    aminoaciduria
    adenoma    pancreatitis    malaria    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for SLC36A1:
    Allan-Herndon-Dudley syndrome     Hartnup disease

    SLC36A1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for SLC36A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iminoglycinuria 92 2 16373326 (1)
    adenoma 37 3 16002564 (1), 11842009 (1), 19940027 (1)


    Export disorders for SLC36A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC36A1 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with SLC36A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization and expression of the SLC36 cluster of amino acid transporter genes. (PubMed id 15058382)1, 2, 7 Bermingham J.R. Jr. and Pennington J. (Mamm. Genome 2004)
    2. A cluster of proton/amino acid transporter genes in the human and mouse genomes. (PubMed id 12809675)1, 2, 9 Boll M.... Daniel H. (Genomics 2003)
    3. Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2. (PubMed id 12527723)1, 2, 9 Chen Z.... Ganapathy V. (J. Physiol. (Lond.) 2003)
    4. Identification of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1. (PubMed id 19549785)1, 2, 9 Dorn M....Bosse-Doenecke E. (J. Biol. Chem. 2009)
    5. Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+ -coupled amino-acid transporter hPAT1. (PubMed id 16331283)1, 7, 9 Abbot E.L....Thwaites D.T. (Br. J. Pharmacol. 2006)
    6. Integral and associated lysosomal membrane proteins. (PubMed id 17897319)1, 2 Schroeder B.... Hasilik A. (Traffic 2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters. (PubMed id 11959859)1, 3 Boll M....Daniel H. (J. Biol. Chem. 2002)
    9. Identification and characterization of a lysosomal transporter for small neutral amino acids. (PubMed id 11390972)1, 3 SagnAc C....Giros B. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    10. Isolation and function of the amino acid transporter PAT1 (slc36a1) from rabbit and discrimination between transport via PAT1 and system IMINO in renal brush-border membrane vesicles. (PubMed id 16373326)7, 9 Miyauchi S....Thwaites D.T. (Mol. Membr. Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 206358 HGNC: 18761 AceView: SLC36A1 Ensembl:ENSG00000123643 euGenes: HUgn206358
    ECgene: SLC36A1 Kegg: 206358 H-InvDB: SLC36A1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC36A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC36A1 gene:
    Search GeneIP for patents involving SLC36A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SLC36A1   OriGene RNAi products in human, mouse, rat for SLC36A1  
     OriGene qPCR primer pairs and template standards for SLC36A1   OriGene Protein Over-expression Lysate for SLC36A1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC36A1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC36A1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC36A1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC36A1   OriGene Custom Protein Services for SLC36A1  

     
     
     Block miRNA regulation of human, mouse, rat SLC36A1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC36A1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC36A1 Predesigned siRNA for gene silencing in human, mouse, rat SLC36A1
     QuantiFast Probe-based Assays in human, mouse, rat SLC36A1 QuantiTect SYBR Green Assays in human, mouse, rat SLC36A1
     Custom PCR Arrays for SLC36A1 Search Chromatin IP Primers for SLC36A1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC36A1  GeneGlobe Interaction Network for SLC36A1
     Regulatory tfbs in SLC36A1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC36A1 GenScript cDNA clones with any tag delivered in your preferred vector for SLC36A1
     GenScript Custom Assay Services for SLC36A1 GenScript Custom overexpressing Cell Line Services for SLC36A1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC36A1 (S36A1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC36A1 antibodies
     SLC36A1 lysates
     Antibodies for SLC36A1
     See all of Abcam's Antibodies, Kits and Proteins for SLC36A1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC36A1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC36A1
     SwitchGear 3'UTR luciferase reporter plasmids for SLC36A1
     SwitchGear Promoter luciferase reporter plasmids for SLC36A1
     Search ThermoFisher Antibodies for SLC36A1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC36A1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC36A1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC36A1
     LSBio Antibodies in human, mouse, rat for SLC36A1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC36A1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4