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Aliases for SLC35G6 Gene

Aliases for SLC35G6 Gene

  • Solute Carrier Family 35 Member G6 2 3 5
  • Transmembrane Protein 21B 2 3 4
  • Acyl-Malonyl-Condensing Enzyme 1-Like Protein 3 3 4
  • Acyl-Malonyl Condensing Enzyme 1-Like 3 2 3
  • AMAC1L3 3 4
  • TMEM21B 3 4
  • Solute Carrier Family 35, Member G6 2
  • Protein AMAC1L3 3

External Ids for SLC35G6 Gene

Previous HGNC Symbols for SLC35G6 Gene

  • TMEM21B
  • AMAC1L3

Previous GeneCards Identifiers for SLC35G6 Gene

  • GC17P007386
  • GC17P007489
  • GC17P007492
  • GC17P007495
  • GC17P007511
  • GC17P007625
  • GC17P007642

Summaries for SLC35G6 Gene

GeneCards Summary for SLC35G6 Gene

SLC35G6 (Solute Carrier Family 35 Member G6) is a Protein Coding gene. An important paralog of this gene is SLC35G5.

Additional gene information for SLC35G6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35G6 Gene

Genomics for SLC35G6 Gene

Regulatory Elements for SLC35G6 Gene

Enhancers for SLC35G6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H007213 1.7 FANTOM5 ENCODE dbSUPER 5.2 -262.6 -262643 10.6 HDGF FOXA2 PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF207 ZNF143 ELP5 CLDN7 GPS2 PER1 LOC100996842 DLG4 SLC35G6 EIF5A WRAP53 EFNB3
GH17H007712 0.7 FANTOM5 6 +231.0 231003 0.2 MXI1 RFX1 BMI1 GLIS2 MYNN GLIS1 ZNF341 EZH2 SPEM1 TMEM95 SPEM2 YBX2 DLG4 SLC35G6 CNTROB ELP5 GC17M007714 DNAH2
GH17H007754 0.3 FANTOM5 12.2 +272.9 272912 0.2 WRAP53 SLC35G6 DNAH2 EFNB3 ALOX15B CYB5D1 TMEM88 NAA38 NLGN2 RPL29P2
GH17H007368 0.3 FANTOM5 4.2 -113.2 -113247 0.1 SLC35G6 WRAP53 SHBG GC17P007361 TNK1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35G6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC35G6 Gene

Genomic Locations for SLC35G6 Gene
2,165 bases
Plus strand

Genomic View for SLC35G6 Gene

Genes around SLC35G6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35G6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35G6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35G6 Gene

Proteins for SLC35G6 Gene

  • Protein details for SLC35G6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 35 member G6
    Protein Accession:

    Protein attributes for SLC35G6 Gene

    338 amino acids
    Molecular mass:
    35103 Da
    Quaternary structure:
    No Data Available
    • This gene appears to be the source locus of an SVA-mediated retrotransposition event that gave rise to SLC35G3, SLC35G4 and SLC35G5 genes.

neXtProt entry for SLC35G6 Gene

Post-translational modifications for SLC35G6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35G6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35G6 Gene

Domains & Families for SLC35G6 Gene

Gene Families for SLC35G6 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35G6 Gene


Suggested Antigen Peptide Sequences for SLC35G6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLC35G solute transporter family.
  • Belongs to the SLC35G solute transporter family.
genes like me logo Genes that share domains with SLC35G6: view

Function for SLC35G6 Gene

Phenotypes From GWAS Catalog for SLC35G6 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC35G6 Gene

Localization for SLC35G6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35G6 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SLC35G6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35G6: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SLC35G6 Gene

Pathways & Interactions for SLC35G6 Gene

SuperPathways for SLC35G6 Gene

No Data Available

Interacting Proteins for SLC35G6 Gene

Gene Ontology (GO) - Biological Process for SLC35G6 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLC35G6 Gene

Drugs & Compounds for SLC35G6 Gene

No Compound Related Data Available

Transcripts for SLC35G6 Gene

mRNA/cDNA for SLC35G6 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC35G6 Gene

Solute carrier family 35, member G6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35G6 Gene

No ASD Table

Relevant External Links for SLC35G6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35G6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35G6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC35G6 Gene

This gene is overexpressed in Testis (x32.1).

Protein differential expression in normal tissues from HIPED for SLC35G6 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC35G6 Gene

Protein tissue co-expression partners for SLC35G6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC35G6 Gene:


SOURCE GeneReport for Unigene cluster for SLC35G6 Gene:


mRNA Expression by UniProt/SwissProt for SLC35G6 Gene:

Tissue specificity: Expressed in placenta and testis.
genes like me logo Genes that share expression patterns with SLC35G6: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35G6 Gene

Orthologs for SLC35G6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC35G6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AMAC1L3 33
  • 98.03 (n)
SLC35G6 34
  • 96 (a)
(Bos Taurus)
Mammalia AMAC1L3 33
  • 87.28 (n)
(Canis familiaris)
Mammalia LOC100688324 33
  • 87.08 (n)
-- 34
  • 82 (a)
(Rattus norvegicus)
Mammalia Slc35g3 33
  • 82.94 (n)
(Mus musculus)
Mammalia Slc35g3 33 16 34
  • 82.74 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
(Danio rerio)
Actinopterygii slc35g2a 34
  • 24 (a)
slc35g2b 34
  • 24 (a)
Species where no ortholog for SLC35G6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35G6 Gene

Gene Tree for SLC35G6 (if available)
Gene Tree for SLC35G6 (if available)

Paralogs for SLC35G6 Gene

Paralogs for SLC35G6 Gene

(4) SIMAP similar genes for SLC35G6 Gene using alignment to 1 proteins: Pseudogenes for SLC35G6 Gene

genes like me logo Genes that share paralogs with SLC35G6: view

Variants for SLC35G6 Gene

Sequence variations from dbSNP and Humsavar for SLC35G6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000442425 -- 7,479,604(+) GCTGC(C/T)GCCGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000743261 -- 7,481,254(+) GAATC(C/T)GGGAG intron-variant, upstream-variant-2KB
rs1001286903 -- 7,483,353(+) CAAAG(-/AC)AGAGC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003286180 -- 7,481,132(+) CACTC(C/T)AGCCT intron-variant, upstream-variant-2KB
rs1003726598 -- 7,481,326(+) AACTT(C/T)GTCGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC35G6 Gene

Variant ID Type Subtype PubMed ID
nsv574322 CNV loss 21841781
nsv523672 CNV loss 19592680
nsv457659 CNV loss 19166990
esv2422288 CNV deletion 17116639

Variation tolerance for SLC35G6 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.95; 79.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35G6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35G6 Gene

Disorders for SLC35G6 Gene

Relevant External Links for SLC35G6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC35G6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35G6 Gene

Publications for SLC35G6 Gene

  1. Emergence of primate genes by retrotransposon-mediated sequence transduction. (PMID: 17101974) Xing J … Batzer MA (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 60
  2. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A … Carracedo A (Gynecologic oncology 2009) 3 60
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 60

Products for SLC35G6 Gene

Sources for SLC35G6 Gene

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