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SLC35G6 Gene

protein-coding   GIFtS: 28
GCID: GC17P007386

Solute Carrier Family 35, Member G6

(Previous names: transmembrane protein 21B, acyl-malonyl condensing enzyme...)
(Previous symbols: TMEM21B, AMAC1L3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 35, Member G61 2     Acyl-Malonyl Condensing Enzyme 1-Like 31 2
Transmembrane Protein 21B1 2 3     Acyl-Malonyl-Condensing Enzyme 1-Like Protein 32 3
AMAC1L31 2 3     Protein AMAC1L32
TMEM21B1 2 3     Solute Carrier Family 35 Member G62

External Ids:    HGNC: 313511   Entrez Gene: 6436642   Ensembl: ENSG000002592247   UniProtKB: P0C7Q63   

Export aliases for SLC35G6 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC35G6 Gene:
SLC35G6 (solute carrier family 35, member G6) is a protein-coding gene. Diseases associated with SLC35G6 include sporadic breast cancer, and breast cancer. An important paralog of this gene is SLC35G5.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SLC35G6
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC35G6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

SLC35G6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35G6 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007386:  view genomic region     (about GC identifiers)

Start:
7,384,721 bp from pter      End:
7,386,383 bp from pter
Size:
1,663 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: S35G6_HUMAN, P0C7Q6 (See protein sequence)
Recommended Name: Solute carrier family 35 member G6  
Size: 338 amino acids; 35103 Da
Miscellaneous: This gene appears to be the source locus of an SVA-mediated retrotransposition event that gave rise
to SLC35G3, SLC35G4 and SLC35G5 genes

Explore the universe of human proteins at neXtProt for SLC35G6: NX_P0C7Q6

Explore proteomics data for SLC35G6 at MOPED


See SLC35G6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001096084.1  
ENSEMBL proteins: 
 ENSP00000396523  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SLC: Solute carriers

1 InterPro protein domain:
 IPR000620 DMT

Graphical View of Domain Structure for InterPro Entry P0C7Q6

ProtoNet protein and cluster: P0C7Q6

UniProtKB/Swiss-Prot: S35G6_HUMAN, P0C7Q6
Similarity: Belongs to the SLC35G solute transporter family
Similarity: Contains 2 EamA domains


SLC35G6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
S35G6_HUMAN, P0C7Q6: Membrane; Multi-pass membrane protein (Potential)

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016020membrane ----
GO:0016021integral component of membrane IEA--

SLC35G6 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC35G6
Interactions:

    Search GeneGlobe Interaction Network for SLC35G6

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for SLC35G6 (S35G6)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SLC35G6 gene: 
NM_001102614.1  

Unigene Cluster for SLC35G6:

Solute carrier family 35, member G6
Hs.632234
Unigene Representative Sequence: NM_001102614
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000412468(uc010cmj.1)
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1 DOTS entry:

DT.92025553 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLC35G6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGACTGTGGC
SLC35G6 Expression
About this image

SLC35G6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLC35G6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.632234

UniProtKB/Swiss-Prot: S35G6_HUMAN, P0C7Q6
Tissue specificity: Expressed in placenta and testis

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SLC35G6 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc35g31 solute carrier family 35, member G3 82.74(n)
81.95(a)
  56293  NM_019871.2  NP_063924.2 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
52(a)
1 → many
GL343660.1(134679-135698)
zebrafish
(Danio rerio)
Actinopterygii slc35g2a6
slc35g2b6
solute carrier family 35, member G2b
24(a)
24(a)
many ↔ many
many ↔ many
2(24759987-24766030) ENSDARG00000056262
24(3491574-3497718) ENSDARG00000045447


ENSEMBL Gene Tree for SLC35G6 (if available)
TreeFam Gene Tree for SLC35G6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SLC35G6 gene
SLC35G52  SLC35G32  SLC35G22  
4 SIMAP similar genes for SLC35G6 using alignment to 1 protein entry:     S35G6_HUMAN:
SLC35G3    SLC35G4    SLC35G5    SLC35G2

SLC35G6 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for SLC35G6
PGOHUM00000259272


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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3 SNPs for SLC35G6    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs37604221,2,4
----see VAR_0443352 mis40--------
rs44915911,2,4
----see VAR_0443362 mis40--------
rs72099771,2,4
----see VAR_0595812 mis40--------

HapMap Linkage Disequilibrium report for SLC35G6 (7384721 - 7386383 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for SLC35G6:    About this table    
Variant IDTypeSubtypePubMed ID
esv2422288CNV Deletion17116639
dgv3054n71CNV Loss21882294
nsv457659CNV Loss19166990
nsv523672CNV Loss19592680

Human Gene Mutation Database (HGMD): SLC35G6
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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2 diseases for SLC35G6:    
About MalaCards
sporadic breast cancer    breast cancer


SLC35G6 for disorders           About GeneDecksing


Export disorders for SLC35G6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SLC35G6 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SLC35G6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Emergence of primate genes by retrotransposon-mediated sequence transduction. (PubMed id 17101974)1, 2 Xing J....Batzer M.A. (Proc. Natl. Acad. Sci. U.S.A. 2006)
  2. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 643664 HGNC: 31351 Ensembl:ENSG00000259224 euGenes: HUgn643664 ECgene: SLC35G6
H-InvDB: SLC35G6

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SLC35G6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SLC35G6 gene:
Search GeneIP for patents involving SLC35G6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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