SLC35G5 Gene
protein-coding GIFtS: 38
GCID: GC08P011189
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solute carrier family 35, member G5(Previous name: acyl-malonyl condensing enzyme 1-like 2 )
(Previous symbols: AMAC, AMAC1L2)
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Aliases
for SLC35G5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 35, Member G51 2 | | Acyl-Malonyl-Condensing Enzyme 1-Like Protein 22 3 | | AMAC1 2 3 | | Protein AMAC1L22 | | AMAC1L21 2 3 | | Solute Carrier Family 35 Member G52 | | Acyl-Malonyl Condensing Enzyme 1-Like 21 2 | | |
Export aliases for SLC35G5 gene to outside databases |
Summaries
for SLC35G5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC35G5:
This gene is intronless and probably arose from retrotransposition of a similar gene. It has high sequence similarityto the gene encoding acyl-malonyl condensing enzyme on chromosome 17. (provided by RefSeq, Aug 2011)
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Genomic Views
for SLC35G5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_077531.4
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SLC35G5
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC35G5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35G5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1SLC35G5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P011189: view genomic region
(about GC identifiers)
Start:
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11,188,397 bp from pter |
End:
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11,189,717 bp from pter |
Size:
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1,321 bases |
Orientation:
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plus strand |
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Proteins
for SLC35G5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S35G5_HUMAN, Q96KT7 (See
protein sequence)Recommended Name: Solute carrier family 35 member G5 Size: 338 amino acids; 35161 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Miscellaneous: The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the SLC35G6gene in the primate lineage
Secondary accessions: A2RRL6Explore the universe of human proteins at neXtProt for SLC35G5: NX_Q96KT7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96KT7
SLC35G5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_473369.1
ENSEMBL proteins: ENSP00000371872
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC35G5 for ontologies About GeneDecksing
SLC35G5 Antibody Products:
Assay Products for SLC35G5: |
Protein
Domains /
Families
for SLC35G5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC35G5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96KT7ProtoNet protein and cluster: Q96KT7 1 Blocks protein family: IPB000620 Protein of unknown function DUF6
UniProtKB/Swiss-Prot: S35G5_HUMAN, Q96KT7Similarity: Belongs to the SLC35G solute transporter familySimilarity: Contains 2 EamA domains |
Function
for SLC35G5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35G5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35G5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35G5 |
1 GenomeRNAi human phenotype for SLC35G5:
|
Pathways & Interactions
for SLC35G5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35G5
|
Drugs & Compounds
for SLC35G5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC35G5
Search CenterWatch for drugs/clinical trials and news about SLC35G5 / S35G5
|
Transcripts
for SLC35G5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC35G5 gene: NM_054028.1 Unigene Cluster for SLC35G5: Solute carrier family 35, member G5 Hs.458397 [show with all ESTs]Unigene Representative Sequence: NM_0540281 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000382435(uc003wtp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35G5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35G5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SLC35G5 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC35G5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35G5 |
Additional cDNA sequence: AJ291677.1 BC131696.1 1 DOTS entry: DT.100018278 8 AceView cDNA sequences: NM_054028 AJ291677 BU729873 BX283231 BU543602 BM703971 CF139278 BM043676
GeneLoc Exon Structure
|
Expression
for SLC35G5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC35G5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGCAGGGG
About this image
See SLC35G5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC35G5
SOURCE GeneReport for Unigene cluster: Hs.458397
UniProtKB/Swiss-Prot: S35G5_HUMAN, Q96KT7Tissue specificity: Expressed in placenta and testis
SABiosciences Custom PCR Arrays for SLC35G5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC35G5
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SLC35G5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35G5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35G5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35G5 |
Orthologs
for SLC35G5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SLC35G5 gene from 2/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
54(a) |
1 → many |
GL343660.1(134679-135698) |
zebrafish
(Danio rerio) |
Actinopterygii |
slc35g2a6 |
solute carrier family 35, member G2a |
23(a) |
1 → many |
2(24759987-24766030) |
Species with no ortholog for SLC35G5
ENSEMBL Gene Tree for SLC35G5 (if available)
TreeFam Gene Tree for SLC35G5 (if available) |
Paralogs
for SLC35G5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC35G5 gene
- SLC35G62 SLC35G32 SLC35G22
3 SIMAP similar genes for SLC35G5 using alignment to 1 protein entry: S35G5_HUMAN:SLC35G4 SLC35G3 SLC35G6
SLC35G5 for paralogs About GeneDecksing
|
Genomic Variants
for SLC35G5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC35G5 (11188397 - 11189717 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC35G5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC35G5 |
|
Disorders
/ Diseases
for SLC35G5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC35G5 for disorders About GeneDecksing
2  diseases for SLC35G5: About MalaCardskeratolytic winter erythema cholesterol
Export disorders for SLC35G5 gene to outside databases
|
Publications
for SLC35G5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC35G5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC35G5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Emergence of primate genes by retrotransposon-mediated sequence transduction. (PubMed id 17101974)1, 2 Xing J....Batzer M.A. (2006)
- Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759. (PubMed id 11896452)1, 2 Appel S.... Rosenthal A. (2002)
- Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. (PubMed id 20972250)1 Park M.H....Park H.Y. (2011)
- Investigation of variants identified in caucasian gen ome-wide association studies for plasma high-density lipoprotein cholesterol an d triglycerides levels in Mexican dyslipidemic study samples. (PubMed id 20160193)1 Weissglas-Volkov D....Pajukanta P. (2010)
- Evaluating the discriminative power of multi-trait ge netic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1 Fontaine-Bisson B....Franks P.W. (2010)
- Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1 Kathiresan S....Cupples L.A. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC35G5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC35G5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC35G5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC35G5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC35G5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC35G5 gene:
Search GeneIP for patents involving SLC35G5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC35G5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | SLC35G5 Proteins, Antibodies, CLIAs, and ELISAs |
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