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Aliases for SLC35G5 Gene

Aliases for SLC35G5 Gene

  • Solute Carrier Family 35 Member G5 2 3 5
  • Acyl-Malonyl-Condensing Enzyme 1-Like Protein 2 3 4
  • Acyl-Malonyl Condensing Enzyme 1-Like 2 2 3
  • AMAC1L2 3 4
  • AMAC 3 4
  • Solute Carrier Family 35, Member G5 2
  • Protein AMAC1L2 3

External Ids for SLC35G5 Gene

Previous HGNC Symbols for SLC35G5 Gene

  • AMAC
  • AMAC1L2

Previous GeneCards Identifiers for SLC35G5 Gene

  • GC08P011189

Summaries for SLC35G5 Gene

Entrez Gene Summary for SLC35G5 Gene

  • This gene is intronless and probably arose from retrotransposition of a similar gene. It has high sequence similarity to the gene encoding acyl-malonyl condensing enzyme on chromosome 17. [provided by RefSeq, Aug 2011]

GeneCards Summary for SLC35G5 Gene

SLC35G5 (Solute Carrier Family 35 Member G5) is a Protein Coding gene. Diseases associated with SLC35G5 include Keratolytic Winter Erythema and Acquired Thrombocytopenia. An important paralog of this gene is SLC35G6.

Additional gene information for SLC35G5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35G5 Gene

Genomics for SLC35G5 Gene

GeneHancer (GH) Regulatory Elements for SLC35G5 Gene

Promoters and enhancers for SLC35G5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I011448 Enhancer 1.1 Ensembl ENCODE dbSUPER 9.7 +118.6 118640 1.8 BCOR KLF1 ZMYM3 ZFHX2 ZNF366 POLR2A ZNF600 EGR2 SP3 SP2 FAM167A BLK LOC105379241 SLC35G5 ENSG00000255310 PIR35143
GH08I011452 Enhancer 0.8 FANTOM5 dbSUPER 9.7 +121.8 121812 0.4 POLR2A IKZF1 NBN EBF1 DPF2 IKZF2 FAM167A BLK LOC105379241 ENSG00000255310 SLC35G5 PIR35143
GH08I011361 Enhancer 0.7 ENCODE 11 +30.8 30751 1.2 FOXA2 CEBPG FOSL2 ZNF600 FOS SMARCE1 FOXA3 CEBPB ELF1 MNT LOC100129129 SLC35G5 RNU6-1084P FAM167A ENSG00000269918 FAM167A-AS1 TDH
GH08I011297 Enhancer 0.7 ENCODE 10.9 -33.2 -33241 0.2 PKNOX1 BMI1 BATF IRF4 RELA ATF7 IKZF2 RUNX3 CBFB IRF5 SLC35G5 LINC00529 MTMR9 ENSG00000280273 PIR36234
GH08I011304 Enhancer 0.6 ENCODE 10.7 -26.3 -26331 0.2 CTCF STAT1 ZNF654 MAFG RAD21 ZNF592 SMARCA4 SCRT2 ZBTB33 NFE2 SLC35G5 ENSG00000280273 PIR36234 MTMR9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC35G5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC35G5 Gene

Genomic Locations for SLC35G5 Gene
chr8:11,330,888-11,332,208
(GRCh38/hg38)
Size:
1,321 bases
Orientation:
Plus strand
chr8:11,188,397-11,189,717
(GRCh37/hg19)

Genomic View for SLC35G5 Gene

Genes around SLC35G5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35G5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35G5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35G5 Gene

Proteins for SLC35G5 Gene

  • Protein details for SLC35G5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KT7-S35G5_HUMAN
    Recommended name:
    Solute carrier family 35 member G5
    Protein Accession:
    Q96KT7
    Secondary Accessions:
    • A2RRL6

    Protein attributes for SLC35G5 Gene

    Size:
    338 amino acids
    Molecular mass:
    35161 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the SLC35G6 gene in the primate lineage.

neXtProt entry for SLC35G5 Gene

Post-translational modifications for SLC35G5 Gene

No Post-translational modifications

Other Protein References for SLC35G5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35G5 Gene

Domains & Families for SLC35G5 Gene

Gene Families for SLC35G5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35G5 Gene

Suggested Antigen Peptide Sequences for SLC35G5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KT7

UniProtKB/Swiss-Prot:

S35G5_HUMAN :
  • Belongs to the SLC35G solute transporter family.
Family:
  • Belongs to the SLC35G solute transporter family.
genes like me logo Genes that share domains with SLC35G5: view

Function for SLC35G5 Gene

genes like me logo Genes that share phenotypes with SLC35G5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC35G5 Gene

Localization for SLC35G5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35G5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35G5 gene
Compartment Confidence
plasma membrane 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC35G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35G5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC35G5 Gene

Pathways & Interactions for SLC35G5 Gene

SuperPathways for SLC35G5 Gene

No Data Available

Interacting Proteins for SLC35G5 Gene

Selected Interacting proteins: Q96KT7-S35G5_HUMAN for SLC35G5 Gene via IID

Symbol External ID(s) Details
FANCE

Gene Ontology (GO) - Biological Process for SLC35G5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC35G5 Gene

Drugs & Compounds for SLC35G5 Gene

No Compound Related Data Available

Transcripts for SLC35G5 Gene

mRNA/cDNA for SLC35G5 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC35G5 Gene

Solute carrier family 35, member G5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35G5 Gene

No ASD Table

Relevant External Links for SLC35G5 Gene

GeneLoc Exon Structure for
SLC35G5
ECgene alternative splicing isoforms for
SLC35G5

Expression for SLC35G5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35G5 Gene

mRNA differential expression in normal tissues according to GTEx for SLC35G5 Gene

This gene is overexpressed in Testis (x10.2).

Protein differential expression in normal tissues from HIPED for SLC35G5 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC35G5 Gene



Protein tissue co-expression partners for SLC35G5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC35G5 Gene:

SLC35G5

SOURCE GeneReport for Unigene cluster for SLC35G5 Gene:

Hs.458397

mRNA Expression by UniProt/SwissProt for SLC35G5 Gene:

Q96KT7-S35G5_HUMAN
Tissue specificity: Expressed in placenta and testis.
genes like me logo Genes that share expression patterns with SLC35G5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35G5 Gene

Orthologs for SLC35G5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC35G5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35G5 33 34
  • 97.53 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slc35g3 34
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii slc35g2a 34
  • 24 (a)
ManyToMany
slc35g2b 34
  • 24 (a)
ManyToMany
Species where no ortholog for SLC35G5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35G5 Gene

ENSEMBL:
Gene Tree for SLC35G5 (if available)
TreeFam:
Gene Tree for SLC35G5 (if available)

Paralogs for SLC35G5 Gene

Paralogs for SLC35G5 Gene

(3) SIMAP similar genes for SLC35G5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC35G5: view

Variants for SLC35G5 Gene

Sequence variations from dbSNP and Humsavar for SLC35G5 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1001286940 -- 11,330,883(+) C/T upstream_transcript_variant
rs1002317865 -- 11,330,168(+) C/T upstream_transcript_variant
rs1002691727 -- 11,330,034(+) G/A upstream_transcript_variant
rs1003040528 -- 11,329,026(+) T/C upstream_transcript_variant
rs1003351349 -- 11,329,623(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35G5 Gene

Variant ID Type Subtype PubMed ID
esv2658364 CNV deletion 23128226
esv34097 CNV loss 18971310
esv3616243 CNV loss 21293372
nsv1033312 CNV loss 25217958
nsv831233 CNV gain 17160897
nsv981910 CNV duplication 23825009

Variation tolerance for SLC35G5 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.11; 96.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35G5 Gene

Human Gene Mutation Database (HGMD)
SLC35G5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35G5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35G5 Gene

Disorders for SLC35G5 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SLC35G5 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
keratolytic winter erythema
  • kwe
acquired thrombocytopenia
  • secondary thrombocytopenia
bacillary angiomatosis
  • angiomatosis, bacillary
corneal dystrophy, reis-bucklers type
  • cdrb
transcobalamin ii deficiency
  • tc ii deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC35G5

genes like me logo Genes that share disorders with SLC35G5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35G5 Gene

Publications for SLC35G5 Gene

  1. Emergence of primate genes by retrotransposon-mediated sequence transduction. (PMID: 17101974) Xing J … Batzer MA (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 58
  2. Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759. (PMID: 11896452) Appel S … Rosenthal A (European journal of human genetics : EJHG 2002) 3 4 58
  3. Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. (PMID: 20972250) Park MH … Park HY (Journal of medical genetics 2011) 3 58
  4. Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. (PMID: 20160193) Weissglas-Volkov D … Pajukanta P (Circulation. Cardiovascular genetics 2010) 3 58
  5. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B … Franks PW (Diabetologia 2010) 3 58

Products for SLC35G5 Gene

Sources for SLC35G5 Gene

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