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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC35G5 Gene

protein-coding   GIFtS: 39
GCID: GC08P011189

Solute Carrier Family 35, Member G5

(Previous name: acyl-malonyl condensing enzyme 1-like 2)
(Previous symbols: AMAC, AMAC1L2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 35, Member G51 2     Acyl-Malonyl-Condensing Enzyme 1-Like Protein 22 3
AMAC1 2 3     Protein AMAC1L22
AMAC1L21 2 3     Solute Carrier Family 35 Member G52
Acyl-Malonyl Condensing Enzyme 1-Like 21 2     

External Ids:    HGNC: 155461   Entrez Gene: 836502   Ensembl: ENSG000001777107   OMIM: 6151995   UniProtKB: Q96KT73   

Export aliases for SLC35G5 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC35G5 Gene:
This gene is intronless and probably arose from retrotransposition of a similar gene. It has high sequence
similarity to the gene encoding acyl-malonyl condensing enzyme on chromosome 17. (provided by RefSeq, Aug 2011)

GeneCards Summary for SLC35G5 Gene: 
SLC35G5 (solute carrier family 35, member G5) is a protein-coding gene. Diseases associated with SLC35G5 include keratolytic winter erythema. An important paralog of this gene is SLC35G6.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_077531.4  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SLC35G5
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SLC35G5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35G5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

SLC35G5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35G5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P011189:  view genomic region     (about GC identifiers)

Start:
11,188,397 bp from pter      End:
11,189,717 bp from pter
Size:
1,321 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S35G5_HUMAN, Q96KT7 (See protein sequence)
Recommended Name: Solute carrier family 35 member G5  
Size: 338 amino acids; 35161 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Miscellaneous: The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the
SLC35G6 gene in the primate lineage
Secondary accessions: A2RRL6

Explore the universe of human proteins at neXtProt for SLC35G5: NX_Q96KT7

Explore proteomics data for SLC35G5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96KT7

  • SLC35G5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC35G5 Protein Expression
    REFSEQ proteins: NP_473369.1  
    ENSEMBL proteins: 
     ENSP00000371872  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLC35G5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    1 InterPro protein domain:
     IPR000620 DMT

    Graphical View of Domain Structure for InterPro Entry Q96KT7

    ProtoNet protein and cluster: Q96KT7

    1 Blocks protein domain: IPB000620 Protein of unknown function DUF6

    UniProtKB/Swiss-Prot: S35G5_HUMAN, Q96KT7
    Similarity: Belongs to the SLC35G solute transporter family
    Similarity: Contains 2 EamA domains


    SLC35G5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for SLC35G5:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35G5

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC35G5 (S35G5)

    Search CenterWatch for drugs/clinical trials and news about SLC35G5 / S35G5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC35G5 gene: 
    NM_054028.1  

    Unigene Cluster for SLC35G5:

    Solute carrier family 35, member G5
    Hs.458397  [show with all ESTs]
    Unigene Representative Sequence: NM_054028
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000382435(uc003wtp.1)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35G5

    Additional mRNA sequence: 

    AJ291677.1 BC131696.1 

    1 DOTS entry:

    DT.100018278 

    8 AceView cDNA sequences:

    NM_054028 AJ291677 BX283231 BU729873 BM703971 BU543602 CF139278 BM043676 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC35G5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGCAGGGG
    SLC35G5 Expression
    About this image


    See SLC35G5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC35G5

    SOURCE GeneReport for Unigene cluster: Hs.458397

    UniProtKB/Swiss-Prot: S35G5_HUMAN, Q96KT7
    Tissue specificity: Expressed in placenta and testis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35G5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC35G5 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    51(a)
    1 → many
    GL343660.1(134679-135698)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52816
    --
    13(a)
    1 → many
    3R(7261572-7263245)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YMR253C6
    YPL264C6
    Putative protein of unknown function; green fluore...
    Putative membrane protein of unknown function; phy...
    9(a)
    13(a)
    many ↔ many
    many ↔ many
    XIII(775946-777190)
    XVI(43283-44344)
            Species with no ortholog for SLC35G5

    ENSEMBL Gene Tree for SLC35G5 (if available)
    TreeFam Gene Tree for SLC35G5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC35G5 gene
    SLC35G62  SLC35G32  SLC35G22  
    3 SIMAP similar genes for SLC35G5 using alignment to 1 protein entry:     S35G5_HUMAN:
    SLC35G4    SLC35G3    SLC35G6

    SLC35G5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/197 SNPs in SLC35G5 are shown (see all 197)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1152954281,2
    C,Funtested111189184(+) CACCAC/TCCTGG 2 T I mis11Minor allele frequency- T:0.02EU 899
    rs1486326461,2
    --11186503(+) TTTGCA/GTATGG 1 -- us2k10--------
    rs1845235931,2
    --11186623(+) ACTCTA/GTTGTG 1 -- us2k10--------
    rs1880999951,2
    --11186638(+) ATTGGA/TGTATA 1 -- us2k10--------
    rs27362641,2
    C,F--11186639(+) TTGGTC/GTATAT 1 -- us2k111Minor allele frequency- G:0.29NA WA CSA EA 372
    rs1926246751,2
    --11186649(+) TGTCTG/TTGTTA 1 -- us2k10--------
    rs795532671,2
    C,F--11186659(+) AATCAC/TTGGAA 1 -- us2k11Minor allele frequency- T:0.07EA 120
    rs27362651,2
    C,F,A--11186674(+) GAGGCG/AGGAGG 1 -- us2k111Minor allele frequency- A:0.33NA WA CSA EA 372
    rs1443425081,2
    --11186700(+) GAGTTC/TGAGAC 1 -- us2k10--------
    rs1166513081,2
    C,F--11186701(+) AGTTCG/AAGACC 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for SLC35G5 (11188397 - 11189717 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC35G5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2658364CNV Deletion23128226
    esv34097CNV Loss18971310
    nsv890354CNV Gain21882294
    nsv831233CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615199    OMIM disorders: --

    2 diseases for SLC35G5:    About MalaCards
    keratolytic winter erythema    


    SLC35G5 for disorders           About GeneDecksing


    Export disorders for SLC35G5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC35G5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLC35G5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Emergence of primate genes by retrotransposon-mediated sequence transduction. (PubMed id 17101974)1, 2 Xing J....Batzer M.A. (2006)
    2. Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759. (PubMed id 11896452)1, 2 Appel S.... Rosenthal A. (2002)
    3. Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. (PubMed id 20972250)1 Park M.H....Park H.Y. (2011)
    4. Investigation of variants identified in caucasian gen ome-wide association studies for plasma high-density lipoprotein cholesterol an d triglycerides levels in Mexican dyslipidemic study samples. (PubMed id 20160193)1 Weissglas-Volkov D....Pajukanta P. (2010)
    5. Evaluating the discriminative power of multi-trait ge netic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1 Fontaine-Bisson B....Franks P.W. (2010)
    6. Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1 Kathiresan S....Cupples L.A. (2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83650 HGNC: 15546 AceView: AMAC Ensembl:ENSG00000177710 euGenes: HUgn83650
    ECgene: SLC35G5 H-InvDB: SLC35G5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC35G5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC35G5 gene:
    Search GeneIP for patents involving SLC35G5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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