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SLC35G5 Gene

protein-coding   GIFtS: 37
GCID: GC08P011189

Solute Carrier Family 35, Member G5

(Previous name: acyl-malonyl condensing enzyme 1-like 2)
(Previous symbols: AMAC, AMAC1L2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 35, Member G51 2     Acyl-Malonyl-Condensing Enzyme 1-Like Protein 22 3
AMAC1 2 3 5     Protein AMAC1L22
AMAC1L21 2 3 5     Solute Carrier Family 35 Member G52
Acyl-Malonyl Condensing Enzyme 1-Like 21 2     

External Ids:    HGNC: 155461   Entrez Gene: 836502   Ensembl: ENSG000001777107   OMIM: 6151995   UniProtKB: Q96KT73   

Export aliases for SLC35G5 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC35G5 Gene:
This gene is intronless and probably arose from retrotransposition of a similar gene. It has high sequence
similarity to the gene encoding acyl-malonyl condensing enzyme on chromosome 17. (provided by RefSeq, Aug 2011)

GeneCards Summary for SLC35G5 Gene:
SLC35G5 (solute carrier family 35, member G5) is a protein-coding gene. Diseases associated with SLC35G5 include keratolytic winter erythema. An important paralog of this gene is SLC35G6.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_077531.5  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SLC35G5
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC35G5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

SLC35G5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35G5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P011189:  view genomic region     (about GC identifiers)

Start:
11,188,397 bp from pter      End:
11,189,717 bp from pter
Size:
1,321 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: S35G5_HUMAN, Q96KT7 (See protein sequence)
Recommended Name: Solute carrier family 35 member G5  
Size: 338 amino acids; 35161 Da
Miscellaneous: The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the
SLC35G6 gene in the primate lineage
Secondary accessions: A2RRL6

Explore the universe of human proteins at neXtProt for SLC35G5: NX_Q96KT7

Explore proteomics data for SLC35G5 at MOPED


See SLC35G5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_473369.1  
ENSEMBL proteins: 
 ENSP00000371872  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SLC: Solute carriers

1 InterPro protein domain:
 IPR000620 DMT

Graphical View of Domain Structure for InterPro Entry Q96KT7

ProtoNet protein and cluster: Q96KT7

1 Blocks protein domain: IPB000620 Protein of unknown function DUF6

UniProtKB/Swiss-Prot: S35G5_HUMAN, Q96KT7
Similarity: Belongs to the SLC35G solute transporter family
Similarity: Contains 2 EamA domains


SLC35G5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for SLC35G5:
 Increased gamma-H2AX phosphory 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
S35G5_HUMAN, Q96KT7: Membrane; Multi-pass membrane protein (Potential)

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016020membrane ----
GO:0016021integral component of membrane IEA--

SLC35G5 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC35G5
Interactions:

    Search GeneGlobe Interaction Network for SLC35G5

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SLC35G5 (S35G5)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SLC35G5 gene: 
NM_054028.1  

Unigene Cluster for SLC35G5:

Solute carrier family 35, member G5
Hs.458397  [show with all ESTs]
Unigene Representative Sequence: NM_054028
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000382435(uc003wtp.1)
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Additional mRNA sequence: 

AJ291677.1 BC131696.1 

1 DOTS entry:

DT.100018278 

8 AceView cDNA sequences:

NM_054028 AJ291677 BU729873 BU543602 BX283231 BM703971 CF139278 BM043676 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLC35G5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGGGCAGGGG
SLC35G5 Expression
About this image

SLC35G5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLC35G5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.458397

UniProtKB/Swiss-Prot: S35G5_HUMAN, Q96KT7
Tissue specificity: Expressed in placenta and testis

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SLC35G5 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
53(a)
1 → many
GL343660.1(134679-135698)
zebrafish
(Danio rerio)
Actinopterygii slc35g2b6
slc35g2a6
solute carrier family 35, member G2a
24(a)
24(a)
many ↔ many
many ↔ many
24(3491574-3497718) ENSDARG00000045447
2(24759987-24766030) ENSDARG00000056262
        Species with no ortholog for SLC35G5

ENSEMBL Gene Tree for SLC35G5 (if available)
TreeFam Gene Tree for SLC35G5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SLC35G5 gene
SLC35G62  SLC35G32  SLC35G22  
3 SIMAP similar genes for SLC35G5 using alignment to 1 protein entry:     S35G5_HUMAN:
SLC35G4    SLC35G3    SLC35G6

SLC35G5 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SLC35G5 (see all 197)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1152954281,2
C,Funtested111189184(+) CACCAC/TCCTGG 2 T I mis11Minor allele frequency- T:0.02EU 899
rs1486326461,2
--11186503(+) TTTGCA/GTATGG 1 -- us2k10--------
rs1845235931,2
--11186623(+) ACTCTA/GTTGTG 1 -- us2k10--------
rs1880999951,2
--11186638(+) ATTGGA/TGTATA 1 -- us2k10--------
rs27362641,2
C,F--11186639(+) TTGGTC/GTATAT 1 -- us2k111Minor allele frequency- G:0.29NA WA CSA EA 372
rs1926246751,2
--11186649(+) TGTCTG/TTGTTA 1 -- us2k10--------
rs795532671,2
C,F--11186659(+) AATCAC/TTGGAA 1 -- us2k11Minor allele frequency- T:0.07EA 120
rs27362651,2
C,F,A--11186674(+) GAGGCG/AGGAGG 1 -- us2k111Minor allele frequency- A:0.33NA WA CSA EA 372
rs1443425081,2
--11186700(+) GAGTTC/TGAGAC 1 -- us2k10--------
rs1166513081,2
C,F--11186701(+) AGTTCG/AAGACC 1 -- us2k11Minor allele frequency- A:0.03WA 118

HapMap Linkage Disequilibrium report for SLC35G5 (11188397 - 11189717 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for SLC35G5:    About this table    
Variant IDTypeSubtypePubMed ID
esv2658364CNV Deletion23128226
esv34097CNV Loss18971310
nsv890354CNV Gain21882294
nsv831233CNV Gain17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 615199    OMIM disorders: --

1 disease for SLC35G5:    About MalaCards
keratolytic winter erythema


SLC35G5 for disorders           About GeneDecksing


Export disorders for SLC35G5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SLC35G5 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SLC35G5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Emergence of primate genes by retrotransposon-mediated sequence transduction. (PubMed id 17101974)1, 2 Xing J....Batzer M.A. (Proc. Natl. Acad. Sci. U.S.A. 2006)
  2. Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759. (PubMed id 11896452)1, 2 Appel S.... Rosenthal A. (Eur. J. Hum. Genet. 2002)
  3. Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. (PubMed id 20972250)1 Park M.H....Park H.Y. (J. Med. Genet. 2011)
  4. Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. (PubMed id 20160193)1 Weissglas-Volkov D....Pajukanta P. (Circ Cardiovasc Genet 2010)
  5. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1 Fontaine-Bisson B....Franks P.W. (Diabetologia 2010)
  6. Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1 Kathiresan S....Cupples L.A. (Nat. Genet. 2009)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 83650 HGNC: 15546 AceView: AMAC Ensembl:ENSG00000177710 euGenes: HUgn83650
ECgene: SLC35G5 H-InvDB: SLC35G5

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SLC35G5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SLC35G5 gene:
Search GeneIP for patents involving SLC35G5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Browse ESI BIO Cell Lines and PureStem Progenitors for SLC35G5
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 Browse SwitchGear Promoter luciferase reporter plasmids for SLC35G5
 ThermoFisher Antibodies for SLC35G5
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35G5
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC35G5
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 LSBio Antibodies in human, mouse, rat for SLC35G5
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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