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Aliases for SLC35G3 Gene

Aliases for SLC35G3 Gene

  • Solute Carrier Family 35 Member G3 2 3 5
  • Transmembrane Protein 21A 2 3 4
  • Acyl-Malonyl-Condensing Enzyme 1 3 4
  • TMEM21A 3 4
  • AMAC1 3 4
  • Solute Carrier Family 35, Member G3 2
  • Acyl-Malonyl Condensing Enzyme 1 2
  • Protein AMAC1 3

External Ids for SLC35G3 Gene

Previous HGNC Symbols for SLC35G3 Gene

  • TMEM21A
  • AMAC1

Previous GeneCards Identifiers for SLC35G3 Gene

  • GC17M033520

Summaries for SLC35G3 Gene

GeneCards Summary for SLC35G3 Gene

SLC35G3 (Solute Carrier Family 35 Member G3) is a Protein Coding gene. Diseases associated with SLC35G3 include Keratolytic Winter Erythema. An important paralog of this gene is SLC35G6.

Additional gene information for SLC35G3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35G3 Gene

Genomics for SLC35G3 Gene

Regulatory Elements for SLC35G3 Gene

Enhancers for SLC35G3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H035212 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -20.6 -20569 5 PKNOX1 ETV1 ZNF133 BATF GABPA OSR2 PRDM6 ZNF157 CUX1 SPI1 SLFN5 NLE1 SLFN12L AP2B1 LINC02001 UNC45B ZNF830 SLC35G3
GH17H035217 1 Ensembl ENCODE dbSUPER 0.3 -24.4 -24351 2 CEBPB FOS NR2F2 SLFN5 UNC45B NLE1 SLFN12L SLC35G3
GH17H035237 0.6 ENCODE dbSUPER 0.3 -44.3 -44300 1 FOS SLFN5 NLE1 SLC35G3
GH17H035235 0.5 ENCODE dbSUPER 0.3 -41.4 -41410 1 SLFN5 SLC35G3
GH17H035192 0.2 Ensembl 0.7 +1.3 1323 0 SLFN5 SLC35G3 ENSG00000267744
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35G3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35G3 Gene

35,192,520 bp from pter
35,194,523 bp from pter
2,004 bases
Minus strand

Genomic View for SLC35G3 Gene

Genes around SLC35G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35G3 Gene

Proteins for SLC35G3 Gene

  • Protein details for SLC35G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 35 member G3
    Protein Accession:
    Secondary Accessions:
    • B9EGE9

    Protein attributes for SLC35G3 Gene

    338 amino acids
    Molecular mass:
    35381 Da
    Quaternary structure:
    No Data Available
    • The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the SLC35G6 gene in the primate lineage.

neXtProt entry for SLC35G3 Gene

Post-translational modifications for SLC35G3 Gene

No Post-translational modifications

Other Protein References for SLC35G3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35G3 Gene

Domains & Families for SLC35G3 Gene

Gene Families for SLC35G3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35G3 Gene

Suggested Antigen Peptide Sequences for SLC35G3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLC35G solute transporter family.
  • Belongs to the SLC35G solute transporter family.
genes like me logo Genes that share domains with SLC35G3: view

Function for SLC35G3 Gene

genes like me logo Genes that share phenotypes with SLC35G3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35G3

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC35G3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35G3 Gene

Localization for SLC35G3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35G3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35G3 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC35G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35G3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC35G3 Gene

Pathways & Interactions for SLC35G3 Gene

SuperPathways for SLC35G3 Gene

No Data Available

Interacting Proteins for SLC35G3 Gene

Gene Ontology (GO) - Biological Process for SLC35G3 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLC35G3 Gene

Drugs & Compounds for SLC35G3 Gene

No Compound Related Data Available

Transcripts for SLC35G3 Gene

mRNA/cDNA for SLC35G3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC35G3 Gene

Solute carrier family 35, member G3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC35G3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35G3 Gene

No ASD Table

Relevant External Links for SLC35G3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35G3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35G3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC35G3 Gene

This gene is overexpressed in Testis (x42.3).

NURSA nuclear receptor signaling pathways regulating expression of SLC35G3 Gene:


SOURCE GeneReport for Unigene cluster for SLC35G3 Gene:


mRNA Expression by UniProt/SwissProt for SLC35G3 Gene:

Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with SLC35G3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35G3 Gene

Orthologs for SLC35G3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC35G3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC35G5 34
  • 93 (a)
(Canis familiaris)
Mammalia -- 34
  • 81 (a)
(Mus musculus)
Mammalia Slc35g3 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
(Danio rerio)
Actinopterygii slc35g2a 34
  • 23 (a)
slc35g2b 34
  • 23 (a)
Species where no ortholog for SLC35G3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35G3 Gene

Gene Tree for SLC35G3 (if available)
Gene Tree for SLC35G3 (if available)

Paralogs for SLC35G3 Gene

Paralogs for SLC35G3 Gene

(3) SIMAP similar genes for SLC35G3 Gene using alignment to 1 proteins: Pseudogenes for SLC35G3 Gene

genes like me logo Genes that share paralogs with SLC35G3: view

Variants for SLC35G3 Gene

Sequence variations from dbSNP and Humsavar for SLC35G3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000041055 -- 35,192,277(+) ACTCT(A/G)TATGT downstream-variant-500B
rs1001858785 -- 35,195,025(+) GCAGA(C/G)GGGCT upstream-variant-2KB
rs1003562164 -- 35,195,966(+) CAGCT(G/T)CGGCT upstream-variant-2KB
rs1003928428 -- 35,195,159(+) CCCCC(A/C)ACCTC upstream-variant-2KB
rs1005558679 -- 35,194,549(+) CATAG(A/G)ACAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC35G3 Gene

Variant ID Type Subtype PubMed ID
dgv569e214 CNV gain 21293372
esv3640443 CNV loss 21293372
esv3892998 CNV loss 25118596
nsv2037 CNV deletion 18451855
nsv962311 CNV duplication 23825009

Variation tolerance for SLC35G3 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.93; 67.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35G3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35G3 Gene

Disorders for SLC35G3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC35G3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
keratolytic winter erythema
  • erythrokeratolysis hiemalis ichthyosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC35G3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC35G3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35G3 Gene

Publications for SLC35G3 Gene

  1. Emergence of primate genes by retrotransposon-mediated sequence transduction. (PMID: 17101974) Xing J … Batzer MA (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60
  5. Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759. (PMID: 11896452) Appel S … Rosenthal A (European journal of human genetics : EJHG 2002) 22 60

Products for SLC35G3 Gene

Sources for SLC35G3 Gene

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