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SLC35G2 Gene

protein-coding   GIFtS: 46
GCID: GC03P136538

Solute Carrier Family 35, Member G2

(Previous name: transmembrane protein 22)
(Previous symbol: TMEM22)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Solute Carrier Family 35, Member G21 2
Transmembrane Protein 221 2 3
TMEM221 2 3
Solute Carrier Family 35 Member G22

External Ids:    HGNC: 284801   Entrez Gene: 807232   Ensembl: ENSG000001689177   UniProtKB: Q8TBE73   
ORGUL members:         

Export aliases for SLC35G2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC35G2 Gene:
SLC35G2 (solute carrier family 35, member G2) is a protein-coding gene. Diseases associated with SLC35G2 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. An important paralog of this gene is SLC35G6.

Gene Wiki entry for SLC35G2 (TMEM22) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SLC35G2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC35G2 promoter sequence
   Search Chromatin IP Primers for SLC35G2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC35G2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q22.3

SLC35G2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35G2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P136538:  view genomic region     (about GC identifiers)

Start:
136,537,489 bp from pter      End:
136,574,734 bp from pter
Size:
37,246 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: S35G2_HUMAN, Q8TBE7 (See protein sequence)
Recommended Name: Solute carrier family 35 member G2  
Size: 412 amino acids; 46422 Da
Sequence caution: Sequence=AAH00111.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RA80 D3DNE1 Q9BWN4 Q9H0S6

Explore the universe of human proteins at neXtProt for SLC35G2: NX_Q8TBE7

Explore proteomics data for SLC35G2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC35G2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001091068.1  NP_001091069.1  NP_079522.2  

    ENSEMBL proteins: 
     ENSP00000400839   ENSP00000376794  

    SLC35G2 Human Recombinant Protein Products:

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    Abcam antibodies for SLC35G2
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    LSBio Antibodies in human, mouse, rat for SLC35G2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    1 InterPro protein domain:
     IPR000620 DMT

    Graphical View of Domain Structure for InterPro Entry Q8TBE7

    ProtoNet protein and cluster: Q8TBE7

    1 Blocks protein domain: IPB000620 Protein of unknown function DUF6

    UniProtKB/Swiss-Prot: S35G2_HUMAN, Q8TBE7
    Similarity: Belongs to the SLC35G solute transporter family
    Similarity: Contains 2 EamA domains


    SLC35G2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for SLC35G2:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC35G2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC35G2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC35G2

    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35G2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S35G2_HUMAN, Q8TBE7: Membrane; Multi-pass membrane protein (Potential)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IDA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    SLC35G2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC35G2
    Interactions:

        Search GeneGlobe Interaction Network for SLC35G2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for SLC35G2 (Q8TBE72, 3 ENSP000003767944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEMA3FQ132752, 3, ENSP000000028294MINT-65449 I2D: score=4 STRING: ENSP00000002829
    ACAP3Q96P503, ENSP000003467334I2D: score=3 STRING: ENSP00000346733
    --Q5T7M82MINT-65450
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC35G2 (S35G2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC35G2 gene (3 alternative transcripts): 
    NM_001097599.1  NM_001097600.1  NM_025246.2  

    Unigene Cluster for SLC35G2:

    Solute carrier family 35, member G2
    Hs.477692  [show with all ESTs]
    Unigene Representative Sequence: BC050423
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472200 ENST00000446465(uc003erf.4 uc003erg.4 uc010hub.3)
    ENST00000393079
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSLC35G2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC35G2
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    Primer
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    OriGene qPCR primer pairs and template standards for SLC35G2
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    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SLC35G2
      QuantiTect SYBR Green Assays in human, mouse, rat SLC35G2
      QuantiFast Probe-based Assays in human, mouse, rat SLC35G2

    Additional mRNA sequence: 

    AK314079.1 AL136661.1 BC000111.1 BC022557.1 BC050423.1 

    4 DOTS entries:

    DT.213792  DT.100816371  DT.40292593  DT.91723069 

    Selected AceView cDNA sequences (see all 84):

    BM272596 CA337753 AK096029 BE465351 BI754884 BI789191 AI141275 BI962644 
    CR602043 BC050423 CK905066 CR618483 BX443405 AI270584 BI962673 CR602057 
    AL136661 BC000111 BM805078 BE439779 BF223250 BM547836 BG184344 Z42659 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC35G2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b
    SP1:                                    
    SP2:              -     -               
    SP3:                    -               


    ECgene alternative splicing isoforms for SLC35G2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC35G2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGACTGCAC
    SLC35G2 Expression
    About this image


    SLC35G2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
    SLC35G2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC35G2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.477692
        Custom PCR Arrays for SLC35G2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35G2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC35G2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc35g21 , 5 transmembrane protein 225
    solute carrier family 35, member G21
    88.27(n)1
    92.23(a)1
      9 (52.74 cM)5
    2450201  NM_001101483.11  NP_001094953.11 
     1005521935 
    chicken
    (Gallus gallus)
    Aves SLC35G21 solute carrier family 35, member G2 76.16(n)
    78.1(a)
      424738  NM_001031299.1  NP_001026470.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC35G26
    solute carrier family 35, member G2
    79(a)
    1 ↔ 1
    3(34783983-34785215)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc35g21 solute carrier family 35, member G2 74.27(n)
    79.37(a)
      100124744  NM_001102725.1  NP_001096195.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc35g2b1 solute carrier family 35, member G2b 67.73(n)
    74.45(a)
      541438  NM_001013563.2  NP_001013581.1 


    ENSEMBL Gene Tree for SLC35G2 (if available)
    TreeFam Gene Tree for SLC35G2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC35G2 gene
    SLC35G62  SLC35G52  SLC35G32  
    2 SIMAP similar genes for SLC35G2 using alignment to 1 protein entry:     S35G2_HUMAN:
    SLC35G6    SLC35G4

    SLC35G2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC35G2 (see all 762)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs729852541,2
    C,F--136536299(+) AATCAA/GAGTAG 3 -- us2k13Minor allele frequency- G:0.06WA CSA 122
    rs1142838431,2
    F--136536302(+) CAAAGT/CAGTCA 3 -- us2k11Minor allele frequency- C:0.01WA 118
    rs98289761,2
    C,F--136536835(+) TGGCTC/GTGGAA 3 -- us2k14Minor allele frequency- G:0.12NA WA 242
    rs1448027511,2
    --136536935(+) ATAGCC/GTCCTG 3 -- us2k10--------
    rs64396631,2
    C,F,A,H--136537044(+) CCCACC/TCCAGG 3 -- us2k126Minor allele frequency- T:0.32NS EA NA WA CSA 2358
    rs1907731091,2
    --136537058(+) GAAGGA/GGCAAG 3 -- us2k10--------
    rs64396641,2
    C,F,A,H--136537074(+) TTAGTA/GGTAAC 3 -- us2k1 tfbs325Minor allele frequency- G:0.32NS EA NA WA CSA 2354
    rs1485340011,2
    --136537117(+) CAGGAC/TGGGAG 3 -- us2k10--------
    rs1815825581,2
    --136537267(+) GTTGAA/CGTAGC 3 -- us2k10--------
    rs1428934141,2
    --136537307(+) AGAGTA/GGAGAG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC35G2 (136537489 - 136574734 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC35G2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC35G2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC35G2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for SLC35G2:    
    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    renal cell carcinoma    hepatitis b
    hepatitis


    SLC35G2 for disorders           About GeneDecksing


    Export disorders for SLC35G2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC35G2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with SLC35G2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. (PubMed id 19148500)1, 9 Dobashi S....Nakamura Y. (Oncol. Rep. 2009)
    5. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    6. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    7. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    8. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80723 HGNC: 28480 AceView: TMEM22 Ensembl:ENSG00000168917 euGenes: HUgn80723
    ECgene: SLC35G2 H-InvDB: SLC35G2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC35G2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC35G2 gene:
    Search GeneIP for patents involving SLC35G2

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC35G2  
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     Block miRNA regulation of human, mouse, rat SLC35G2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC35G2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC35G2 Predesigned siRNA for gene silencing in human, mouse, rat SLC35G2
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     Search Tocris compounds for SLC35G2 (S35G2)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC35G2
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35G2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC35G2
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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