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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC35G2 Gene

protein-coding   GIFtS: 45
GCID: GC03P136538

Solute Carrier Family 35, Member G2

(Previous name: transmembrane protein 22)
(Previous symbol: TMEM22)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 35, Member G21 2
Transmembrane Protein 221 2 3
TMEM221 2 3
Solute Carrier Family 35 Member G22

External Ids:    HGNC: 284801   Entrez Gene: 807232   Ensembl: ENSG000001689177   UniProtKB: Q8TBE73   

Export aliases for SLC35G2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC35G2 Gene: 
SLC35G2 (solute carrier family 35, member G2) is a protein-coding gene. Diseases associated with SLC35G2 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. An important paralog of this gene is SLC35G6.

Gene Wiki entry for SLC35G2 (TMEM22) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SLC35G2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC35G2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC35G2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35G2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q22.3

SLC35G2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35G2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P136538:  view genomic region     (about GC identifiers)

Start:
136,537,489 bp from pter      End:
136,574,734 bp from pter
Size:
37,246 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S35G2_HUMAN, Q8TBE7 (See protein sequence)
Recommended Name: Solute carrier family 35 member G2  
Size: 412 amino acids; 46422 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH00111.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RA80 D3DNE1 Q9BWN4 Q9H0S6

Explore the universe of human proteins at neXtProt for SLC35G2: NX_Q8TBE7

Explore proteomics data for SLC35G2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TBE7

  • SLC35G2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC35G2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001091068.1  NP_001091069.1  NP_079522.2  

    ENSEMBL proteins: 
     ENSP00000400839   ENSP00000376794  

    Human Recombinant Protein Products for SLC35G2: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IDA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLC35G2 for ontologies           About GeneDecksing



    SLC35G2 Antibody Products: 
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    Novus Biologicals SLC35G2 Antibody
    Abcam antibodies for SLC35G2
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    1 InterPro protein domain:
     IPR000620 DMT

    Graphical View of Domain Structure for InterPro Entry Q8TBE7

    ProtoNet protein and cluster: Q8TBE7

    1 Blocks protein domain: IPB000620 Protein of unknown function DUF6

    UniProtKB/Swiss-Prot: S35G2_HUMAN, Q8TBE7
    Similarity: Belongs to the SLC35G solute transporter family
    Similarity: Contains 2 EamA domains


    SLC35G2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for SLC35G2:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC35G2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC35G2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC35G2 
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    miRNA
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    Inhib. RNA
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    Gene Editing
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    Cell Line
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    Search LifeMap BioReagents cell lines for SLC35G2
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35G2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35G2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for SLC35G2 (Q8TBE72, 3 ENSP000003767944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEMA3FQ132752, 3, ENSP000000028294MINT-65449 I2D: score=4 STRING: ENSP00000002829
    ACAP3Q96P503, ENSP000003467334I2D: score=3 STRING: ENSP00000346733
    --Q5T7M82MINT-65450
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC35G2 (S35G2)

    Search CenterWatch for drugs/clinical trials and news about SLC35G2 / S35G2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC35G2 gene (3 alternative transcripts): 
    NM_001097599.1  NM_001097600.1  NM_025246.2  

    Unigene Cluster for SLC35G2:

    Solute carrier family 35, member G2
    Hs.477692  [show with all ESTs]
    Unigene Representative Sequence: BC050423
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472200 ENST00000446465(uc003erf.4 uc003erg.4 uc010hub.3)
    ENST00000393079
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SLC35G2
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC35G2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC35G2
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    OriGene clones in human, mouse for SLC35G2 (see all 18)
    OriGene ORF clones in mouse, rat for SLC35G2
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    Sirion Biotech Customized lentivirus for stable overexpression of SLC35G2 
                         Customized lentivirus expression plasmids for stable overexpression of SLC35G2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC35G2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35G2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35G2

    Additional mRNA sequence: 

    AK314079.1 AL136661.1 BC000111.1 BC022557.1 BC050423.1 

    4 DOTS entries:

    DT.213792  DT.100816371  DT.40292593  DT.91723069 

    24/84 AceView cDNA sequences (see all 84):

    BI962673 CR602057 CA337753 AI270584 BM272596 BI789191 BX443405 BE465351 
    CR602043 CK905066 AK096029 CR618483 AI141275 BC050423 BI754884 BI962644 
    F11879 BM922058 AI081759 BG218745 NM_025246 BM845114 BX378068 BE551333 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC35G2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b
    SP1:                                    
    SP2:              -     -               
    SP3:                    -               


    ECgene alternative splicing isoforms for SLC35G2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC35G2 expression in normal human tissues (normalized intensities)      SLC35G2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGACTGCAC
    SLC35G2 Expression
    About this image


    SLC35G2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Neural Crest (Sensory Organs)
             sensory organ/nose/vomeronasal organ   

    See SLC35G2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC35G2

    SOURCE GeneReport for Unigene cluster: Hs.477692
        SABiosciences Custom PCR Arrays for SLC35G2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35G2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC35G2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc35g25
    Tmem221
    transmembrane protein 221, 5 88.27(n)1
    92.23(a)1
      9 (52.74 cM)5
    2450201  NM_001101483.11  NP_001094953.11 
     1005521935 
    chicken
    (Gallus gallus)
    Aves SLC35G21 transmembrane protein 22 76.16(n)
    78.1(a)
      424738  NM_001031299.1  NP_001026470.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC35G26
    Uncharacterized protein
    79(a)
    1 ↔ 1
    3(34783983-34785215)
    zebrafish
    (Danio rerio)
    Actinopterygii slc35g2b1 solute carrier family 35, member G2b 67.32(n)
    73.77(a)
      541438  NM_001013563.1  NP_001013581.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52816
    --
    18(a)
    1 → many
    3R(7261572-7263245)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPL264C6
    YMR253C6
    Putative membrane protein of unknown function; phy...
    Putative protein of unknown function; green fluore...
    12(a)
    12(a)
    many ↔ many
    many ↔ many
    XVI(43283-44344)
    XIII(775946-777190)


    ENSEMBL Gene Tree for SLC35G2 (if available)
    TreeFam Gene Tree for SLC35G2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC35G2 gene
    SLC35G62  SLC35G52  SLC35G32  
    2 SIMAP similar genes for SLC35G2 using alignment to 1 protein entry:     S35G2_HUMAN:
    SLC35G6    SLC35G4

    SLC35G2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/762 SNPs in SLC35G2 are shown (see all 762)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs729852541,2
    C,F--136536299(+) AATCAA/GAGTAG 3 -- us2k13Minor allele frequency- G:0.06WA CSA 122
    rs1142838431,2
    F--136536302(+) CAAAGT/CAGTCA 3 -- us2k11Minor allele frequency- C:0.01WA 118
    rs98289761,2
    C,F--136536835(+) TGGCTC/GTGGAA 3 -- us2k14Minor allele frequency- G:0.12NA WA 242
    rs1448027511,2
    --136536935(+) ATAGCC/GTCCTG 3 -- us2k10--------
    rs64396631,2
    C,F,A,H--136537044(+) CCCACC/TCCAGG 3 -- us2k126Minor allele frequency- T:0.32NS EA NA WA CSA 2358
    rs1907731091,2
    --136537058(+) GAAGGA/GGCAAG 3 -- us2k10--------
    rs64396641,2
    C,F,A,H--136537074(+) TTAGTA/GGTAAC 3 -- us2k1 tfbs325Minor allele frequency- G:0.32NS EA NA WA CSA 2354
    rs1485340011,2
    --136537117(+) CAGGAC/TGGGAG 3 -- us2k10--------
    rs1815825581,2
    --136537267(+) GTTGAA/CGTAGC 3 -- us2k10--------
    rs1428934141,2
    --136537307(+) AGAGTA/GGAGAG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC35G2 (136537489 - 136574734 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC35G2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC35G2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC35G2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for SLC35G2:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    renal cell carcinoma    hepatitis b
    hepatitis


    SLC35G2 for disorders           About GeneDecksing


    Export disorders for SLC35G2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC35G2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with SLC35G2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. (PubMed id 19148500)1, 9 Dobashi S....Nakamura Y. (2009)
    5. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    6. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    7. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    8. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80723 HGNC: 28480 AceView: TMEM22 Ensembl:ENSG00000168917 euGenes: HUgn80723
    ECgene: SLC35G2 H-InvDB: SLC35G2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC35G2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC35G2 gene:
    Search GeneIP for patents involving SLC35G2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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