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Aliases for SLC35G2 Gene

Aliases for SLC35G2 Gene

  • Solute Carrier Family 35 Member G2 2 3 5
  • Transmembrane Protein 22 2 3 4
  • Solute Carrier Family 35, Member G2 2 3
  • TMEM22 3 4

External Ids for SLC35G2 Gene

Previous HGNC Symbols for SLC35G2 Gene

  • TMEM22

Previous GeneCards Identifiers for SLC35G2 Gene

  • GC03P136538

Summaries for SLC35G2 Gene

GeneCards Summary for SLC35G2 Gene

SLC35G2 (Solute Carrier Family 35 Member G2) is a Protein Coding gene. An important paralog of this gene is SLC35G5.

UniProtKB/Swiss-Prot for SLC35G2 Gene

  • May play a role in cell proliferation.

Gene Wiki entry for SLC35G2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35G2 Gene

Genomics for SLC35G2 Gene

Regulatory Elements for SLC35G2 Gene

Enhancers for SLC35G2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC35G2 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35G2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC35G2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35G2 Gene

Chromosome:
3
Start:
136,818,647 bp from pter
End:
136,855,892 bp from pter
Size:
37,246 bases
Orientation:
Plus strand

Genomic View for SLC35G2 Gene

Genes around SLC35G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35G2 Gene

Proteins for SLC35G2 Gene

  • Protein details for SLC35G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBE7-S35G2_HUMAN
    Recommended name:
    Solute carrier family 35 member G2
    Protein Accession:
    Q8TBE7
    Secondary Accessions:
    • B2RA80
    • D3DNE1
    • Q9BWN4
    • Q9H0S6

    Protein attributes for SLC35G2 Gene

    Size:
    412 amino acids
    Molecular mass:
    46422 Da
    Quaternary structure:
    • Interacts with RAB37.
    SequenceCaution:
    • Sequence=AAH00111.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SLC35G2 Gene

Proteomics data for SLC35G2 Gene at MOPED

Post-translational modifications for SLC35G2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35G2 Gene

No data available for DME Specific Peptides for SLC35G2 Gene

Domains & Families for SLC35G2 Gene

Gene Families for SLC35G2 Gene

Protein Domains for SLC35G2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35G2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBE7

UniProtKB/Swiss-Prot:

S35G2_HUMAN :
  • Contains 2 EamA domains.
  • Belongs to the SLC35G solute transporter family.
Domain:
  • Contains 2 EamA domains.
Family:
  • Belongs to the SLC35G solute transporter family.
genes like me logo Genes that share domains with SLC35G2: view

Function for SLC35G2 Gene

Molecular function for SLC35G2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell proliferation.

Phenotypes for SLC35G2 Gene

genes like me logo Genes that share phenotypes with SLC35G2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35G2 Gene

Localization for SLC35G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35G2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35G2 Gene COMPARTMENTS Subcellular localization image for SLC35G2 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC35G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 19148500
GO:0005887 integral component of plasma membrane TAS 19148500
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35G2: view

Pathways & Interactions for SLC35G2 Gene

SuperPathways for SLC35G2 Gene

No Data Available

Interacting Proteins for SLC35G2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000376794%0d%0a9606.ENSP00000002829%0d%0a
Selected Interacting proteins: Q8TBE7-S35G2_HUMAN ENSP00000376794 for SLC35G2 Gene via I2D STRING MINT

Gene Ontology (GO) - Biological Process for SLC35G2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC35G2 Gene

Drugs & Compounds for SLC35G2 Gene

No Compound Related Data Available

Transcripts for SLC35G2 Gene

Unigene Clusters for SLC35G2 Gene

Solute carrier family 35, member G2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35G2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b
SP1:
SP2: - -
SP3: -

Relevant External Links for SLC35G2 Gene

GeneLoc Exon Structure for
SLC35G2
ECgene alternative splicing isoforms for
SLC35G2

Expression for SLC35G2 Gene

mRNA expression in normal human tissues for SLC35G2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for SLC35G2 Gene Hs.477692

genes like me logo Genes that share expression patterns with SLC35G2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC35G2 Gene

Orthologs for SLC35G2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC35G2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM22 35
  • 93.43 (n)
  • 95.13 (a)
TMEM22 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC35G2 35
  • 94.5 (n)
  • 97.09 (a)
SLC35G2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35g2 35
  • 88.27 (n)
  • 92.23 (a)
Slc35g2 16
Slc35g2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC35G2 35
  • 99.43 (n)
  • 98.79 (a)
SLC35G2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35g2 35
  • 87.62 (n)
  • 91.75 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC35G2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35G2 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35G2 35
  • 76.16 (n)
  • 78.1 (a)
SLC35G2 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35G2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35g2 35
  • 74.27 (n)
  • 79.37 (a)
zebrafish
(Danio rerio)
Actinopterygii slc35g2b 35
  • 67.73 (n)
  • 74.45 (a)
Species with no ortholog for SLC35G2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35G2 Gene

ENSEMBL:
Gene Tree for SLC35G2 (if available)
TreeFam:
Gene Tree for SLC35G2 (if available)

Paralogs for SLC35G2 Gene

Paralogs for SLC35G2 Gene

(2) SIMAP similar genes for SLC35G2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC35G2: view

Variants for SLC35G2 Gene

Sequence variations from dbSNP and Humsavar for SLC35G2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_026907 -
rs1914048 -- 136,828,548(+) gtata(A/G)ctact intron-variant
rs7610507 -- 136,819,349(+) GGGCA(A/C/G)AACAG intron-variant, utr-variant-5-prime
rs1400261 -- 136,819,135(-) GGCGC(C/T)GCCCG utr-variant-5-prime
rs1400262 -- 136,819,133(-) CGCTG(C/T)CCGGA utr-variant-5-prime

Variation tolerance for SLC35G2 Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35G2 Gene

Human Gene Mutation Database (HGMD)
SLC35G2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC35G2 Gene

Disorders for SLC35G2 Gene

Relevant External Links for SLC35G2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35G2

No disorders were found for SLC35G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35G2 Gene

Publications for SLC35G2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. (PMID: 19148500) Dobashi S. … Nakamura Y. (Oncol. Rep. 2009) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for SLC35G2 Gene

Sources for SLC35G2 Gene

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