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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC35G1 Gene

protein-coding   GIFtS: 37
GCID: GC10P095653

Solute Carrier Family 35, Member G1

(Previous name: transmembrane protein 20)
(Previous symbol: TMEM20)
  Search for SLC35G1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 35, Member G11 2
Transmembrane Protein 201 2 3
TMEM201 2 3
C10orf602 3
Solute Carrier Family 35 Member G12

External Ids:    HGNC: 266071   Entrez Gene: 1593712   Ensembl: ENSG000001762737   UniProtKB: Q2M3R53   

Export aliases for SLC35G1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC35G1 Gene: 
SLC35G1 (solute carrier family 35, member G1) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SLC35G1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC35G1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC35G1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35G1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.33   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q23.33

SLC35G1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35G1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P095653:  view genomic region     (about GC identifiers)

Start:
95,653,730 bp from pter      End:
95,715,819 bp from pter
Size:
62,090 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S35G1_HUMAN, Q2M3R5 (See protein sequence)
Recommended Name: Solute carrier family 35 member G1  
Size: 365 amino acids; 39836 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q86YG5 Q8NBA5
Alternative splicing: 2 isoforms:  Q2M3R5-1   Q2M3R5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC35G1: NX_Q2M3R5

Explore proteomics data for SLC35G1 at MOPED 

SLC35G1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SLC35G1 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001128130.1  NP_694958.1  

ENSEMBL proteins: 
 ENSP00000360462   ENSP00000473766   ENSP00000474890   ENSP00000474294   ENSP00000473862  
 ENSP00000400932  

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016020membrane ----
GO:0016021integral to membrane IEA--

SLC35G1 for ontologies           About GeneDecksing



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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
SLC: Solute carriers

1 InterPro protein domain:
 IPR000620 DMT

Graphical View of Domain Structure for InterPro Entry Q2M3R5

ProtoNet protein and cluster: Q2M3R5

1 Blocks protein domain: IPB000620 Protein of unknown function DUF6

UniProtKB/Swiss-Prot: S35G1_HUMAN, Q2M3R5
Similarity: Belongs to the TMEM20 family
Similarity: Contains 2 EamA domains


SLC35G1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35G1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35G1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SLC35G1 (ENSP000004009324) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ELAVL1ENSP000003852694STRING: ENSP00000385269
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC35G1 (S35G1)

Search CenterWatch for drugs/clinical trials and news about SLC35G1 / S35G1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC35G1 gene (2 alternative transcripts): 
NM_001134658.1  NM_153226.2  

Unigene Clusters for SLC35G1:

Solute carrier family 35, member G1
Hs.632085  [show with all ESTs], Hs.744369  [show with all ESTs]
Unigene Representative Sequences: BC036382, NM_001134658
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000371408(uc001kjf.2) ENST00000483386(uc001kjj.3) ENST00000605679
ENST00000494992(uc001kji.3) ENST00000603665 ENST00000427197(uc001kjg.2 uc010qnw.2)

miRNA
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Inhib. RNA
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Clone
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                     Customized lentivirus expression plasmids for stable overexpression of SLC35G1 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for SLC35G1
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35G1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35G1

Additional mRNA sequence: 

AK091309.1 BC041432.1 BC047102.1 BC058549.1 BC104814.1 BC143283.1 BC143284.1 

5 DOTS entries:

DT.101981299  DT.95348842  DT.80102087  DT.91910608  DT.75101076 

24/62 AceView cDNA sequences (see all 62):

AI806366 BF436731 AA970469 BQ949564 AI913269 AI123333 BE222897 AI272306 
BC058549 BC041432 AI381815 AI079932 AW072925 AA514200 AI334154 BM722667 
AW197339 AI266203 AI435509 BG403158 AI914012 AW009005 BI547176 AI452512 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC35G1    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:                        
SP2:                        


ECgene alternative splicing isoforms for SLC35G1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC35G1 expression in normal human tissues (normalized intensities)      SLC35G1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTGATTGAC
SLC35G1 Expression
About this image


SLC35G1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
         sigmoid colon mucosa   
 
 Gut Tube (Gastrointestinal Tract)
         Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
 
 Adipose (Muscoskeletal System)
         Mesenchymal Stem Cells Subcutaneous White Adipose
 
 Bone (Muscoskeletal System)
         Zeugopod Growth Plate
 
 Blood (Hematopoietic System)
         platelets   

See SLC35G1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC35G1

SOURCE GeneReport for Unigene clusters: Hs.632085 Hs.744369
    SABiosciences Custom PCR Arrays for SLC35G1
Primer
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35G1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35G1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35G1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC35G1 gene from 6/14 species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc35g15
Tmem201
transmembrane protein 201, 5 83(n)1
81.02(a)1
  19 (33.03 cM)5
2406601  NM_175507.31  NP_780716.11 
 383959805 
chicken
(Gallus gallus)
Aves SLC35G16
Uncharacterized protein
61(a)
1 ↔ 1
6(19821569-19832272)
lizard
(Anolis carolinensis)
Reptilia SLC35G16
Uncharacterized protein
55(a)
1 ↔ 1
GL343219.1(1637441-1661860)
zebrafish
(Danio rerio)
Actinopterygii LOC1000019201 transmembrane protein 20-like 62.85(n)
61.44(a)
  100001920  XM_001341786.1  XP_001341822.1 
fruit fly
(Drosophila melanogaster)
Insecta CG52811 CG5281 49.58(n)
40.45(a)
  41375  NM_141819.2  NP_650076.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes (YPL264C)4
YPL264C1
Putative membrane protein of unknown function; physically more4
hypothetical protein1
45.12(n)1
30.13(a)1
  16(44344-43283)4
8558641, 4  NP_015059.11, 4 


ENSEMBL Gene Tree for SLC35G1 (if available)
TreeFam Gene Tree for SLC35G1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SLC35G1 gene
1 SIMAP similar gene for SLC35G1 using alignment to 1 protein entry:     S35G1_HUMAN:
TMEM20

SLC35G1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/228 SNPs in SLC35G1 are shown (see all 228)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1440437871,2
C,Funtested195660576(+) CTACCG/ACCATG 4 /T /A mis11Minor allele frequency- A:0.00NA 4550
rs1851103711,2
--95652069(+) ATATCA/GAAATC 2 -- us2k10--------
rs79120801,2
C,F,H--95652095(+) GAAACT/CGCACT 2 -- us2k110Minor allele frequency- C:0.14NS EA NA CSA WA 759
rs65839201,2
C,F,A,H--95652107(+) GACTTT/CCCAGA 2 -- us2k121Minor allele frequency- C:0.10NS EA NA WA CSA 933
rs1901108291,2
--95652119(+) ATTTGA/GGGAAG 2 -- us2k10--------
rs70882361,2
C,F,A,H--95652130(+) CTTCCA/TGGTTC 2 -- us2k1 tfbs325Minor allele frequency- N:0.00NS EA NA WA 1786
rs596929761,2
C,F--95652201(+) ACAACG/AACAAC 2 -- us2k14Minor allele frequency- A:0.12WA CSA NA 242
rs1818132111,2
--95652256(+) AAAAGC/TATTAT 2 -- us2k10--------
rs1847392811,2
--95652264(+) TATTAA/TTTTTT 2 -- us2k10--------
rs1405361441,2
--95652283(+) ACAAGA/GTCTAT 2 -- us2k10--------

HapMap Linkage Disequilibrium report for SLC35G1 (95653730 - 95715819 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SLC35G1: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing SLC35G1
DNA2.0 Custom Variant and Variant Library Synthesis for SLC35G1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SLC35G1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC35G1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Functional specialization in nucleotide sugar transpo rters occurred through differentiation of the gene cluster EamA (DUF6) before t he radiation of Viridiplantae. (PubMed id 21569384)1, 3 VAostermark A.8....SchiAPth H.B. (2011)
  2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 159371 HGNC: 26607 AceView: TMEM20 Ensembl:ENSG00000176273 euGenes: HUgn159371
ECgene: SLC35G1 H-InvDB: SLC35G1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SLC35G1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SLC35G1 gene:
Search GeneIP for patents involving SLC35G1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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