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SLC35G1 Gene

protein-coding   GIFtS: 38
GCID: GC10P095653

Solute Carrier Family 35, Member G1

(Previous name: transmembrane protein 20)
(Previous symbol: TMEM20)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 35, Member G11 2
Transmembrane Protein 201 2 3
TMEM201 2 3
C10orf602 3
Solute Carrier Family 35 Member G12

External Ids:    HGNC: 266071   Entrez Gene: 1593712   Ensembl: ENSG000001762737   UniProtKB: Q2M3R53   

Export aliases for SLC35G1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC35G1 Gene:
SLC35G1 (solute carrier family 35, member G1) is a protein-coding gene. Diseases associated with SLC35G1 include malaria.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SLC35G1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC35G1 promoter sequence
   Search Chromatin IP Primers for SLC35G1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC35G1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.33   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q23.33

SLC35G1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35G1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P095653:  view genomic region     (about GC identifiers)

Start:
95,653,730 bp from pter      End:
95,715,819 bp from pter
Size:
62,090 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: S35G1_HUMAN, Q2M3R5 (See protein sequence)
Recommended Name: Solute carrier family 35 member G1  
Size: 365 amino acids; 39836 Da
Secondary accessions: Q86YG5 Q8NBA5
Alternative splicing: 2 isoforms:  Q2M3R5-1   Q2M3R5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC35G1: NX_Q2M3R5

Explore proteomics data for SLC35G1 at MOPED


See SLC35G1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001128130.1  NP_694958.1  

ENSEMBL proteins: 
 ENSP00000360462   ENSP00000473766   ENSP00000474890   ENSP00000474294   ENSP00000473862  
 ENSP00000400932  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SLC: Solute carriers

1 InterPro protein domain:
 IPR000620 DMT

Graphical View of Domain Structure for InterPro Entry Q2M3R5

ProtoNet protein and cluster: Q2M3R5

1 Blocks protein domain: IPB000620 Protein of unknown function DUF6

UniProtKB/Swiss-Prot: S35G1_HUMAN, Q2M3R5
Similarity: Belongs to the TMEM20 family
Similarity: Contains 2 EamA domains


SLC35G1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC35G1
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35G1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
S35G1_HUMAN, Q2M3R5: Membrane; Multi-pass membrane protein (Potential)

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016020membrane ----
GO:0016021integral component of membrane IEA--

SLC35G1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC35G1
Interactions:

    Search GeneGlobe Interaction Network for SLC35G1

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SLC35G1 (ENSP000004009324) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ELAVL1ENSP000003852694STRING: ENSP00000385269
SLC35B4ENSP000003677704STRING: ENSP00000367770
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SLC35G1 (S35G1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SLC35G1 gene (2 alternative transcripts): 
NM_001134658.1  NM_153226.2  

Unigene Cluster for SLC35G1:

Solute carrier family 35, member G1
Hs.632085  [show with all ESTs]
Unigene Representative Sequence: BC036382
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000371408(uc001kjf.2) ENST00000483386(uc001kjj.3) ENST00000605679
ENST00000494992(uc001kji.3) ENST00000603665 ENST00000427197(uc001kjg.2 uc010qnw.2)

miRNA
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Primer
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OriGene qPCR primer pairs and template standards for SLC35G1
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  QuantiFast Probe-based Assays in human, mouse, rat SLC35G1

Additional mRNA sequence: 

AK123062.1 AK123734.1 BC036382.1 

2 DOTS entries:

DT.101981299  DT.80102087 

Selected AceView cDNA sequences (see all 62):

BF436731 BE222897 BM722667 AW197339 AI272306 AW072925 BC058549 AI913269 
AI381815 AI079932 BQ949564 AI266203 BC041432 AA514200 AI806366 AA970469 
AI334154 AI123333 AX746907 AK123062 AI435509 AI264307 BX115776 AI298006 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC35G1    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:                        
SP2:                        


ECgene alternative splicing isoforms for SLC35G1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLC35G1 expression in normal human tissues (normalized intensities)      SLC35G1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTGATTGAC
SLC35G1 Expression
About this image


SLC35G1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Adipose (Muscoskeletal System)
         Mesenchymal Stem Cells Subcutaneous White Adipose
 
 Bone (Muscoskeletal System)
         Zeugopod Growth Plate
 
 Mesenchymal Stem Cells
         Mesenchymal Stem Cells Subcutaneous White Adipose
SLC35G1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLC35G1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.632085
    Custom PCR Arrays for SLC35G1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35G1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC35G1 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc35g11 , 5 transmembrane protein 205
solute carrier family 35, member G11
81.96(n)1
79.89(a)1
  19 (33.03 cM)5
2406601  NM_175507.31  NP_780716.11 
 383959805 
chicken
(Gallus gallus)
Aves SLC35G11 solute carrier family 35, member G1 73.99(n)
74.61(a)
  423800  XM_004942154.1  XP_004942211.1 
lizard
(Anolis carolinensis)
Reptilia SLC35G16
solute carrier family 35, member G1
58(a)
1 ↔ 1
GL343219.1(1637441-1661860)
tropical clawed frog
(Xenopus tropicalis)
Amphibia slc35g11 solute carrier family 35, member G1 66.25(n)
66.98(a)
  100487258  XM_002937193.2  XP_002937239.2 
zebrafish
(Danio rerio)
Actinopterygii LOC1000019201 solute carrier family 35 member G1-like 61.85(n)
59.38(a)
  100001920  XM_001341786.2  XP_001341822.1 
fruit fly
(Drosophila melanogaster)
Insecta CG52811 CG5281 49.66(n)
40.6(a)
  41375  NM_141819.2  NP_650076.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes (YPL264C)4
YPL264C1
Putative membrane protein of unknown function; physically more4
YPL264C1
45.37(n)1
30.84(a)1
  16(44344-43283)4
8558641, 4  NP_015059.11, 4 


ENSEMBL Gene Tree for SLC35G1 (if available)
TreeFam Gene Tree for SLC35G1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SLC35G1 gene
1 SIMAP similar gene for SLC35G1 using alignment to 2 protein entries:     S35G1_HUMAN (see all proteins):
TMEM20

SLC35G1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SLC35G1 (see all 228)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1440437871,2
C,Funtested195660576(+) CTACCG/ACCATG 4 /T /A mis11Minor allele frequency- A:0.00NA 4550
rs1851103711,2
--95652069(+) ATATCA/GAAATC 2 -- us2k10--------
rs79120801,2
C,F,H--95652095(+) GAAACT/CGCACT 2 -- us2k110Minor allele frequency- C:0.14NS EA NA CSA WA 759
rs65839201,2
C,F,A,H--95652107(+) GACTTT/CCCAGA 2 -- us2k121Minor allele frequency- C:0.10NS EA NA WA CSA 933
rs1901108291,2
--95652119(+) ATTTGA/GGGAAG 2 -- us2k10--------
rs70882361,2
C,F,A,H--95652130(+) CTTCCA/TGGTTC 2 -- us2k1 tfbs325Minor allele frequency- N:0.00NS EA NA WA 1786
rs596929761,2
C,F--95652201(+) ACAACG/AACAAC 2 -- us2k14Minor allele frequency- A:0.12WA CSA NA 242
rs1818132111,2
--95652256(+) AAAAGC/TATTAT 2 -- us2k10--------
rs1847392811,2
--95652264(+) TATTAA/TTTTTT 2 -- us2k10--------
rs1405361441,2
--95652283(+) ACAAGA/GTCTAT 2 -- us2k10--------

HapMap Linkage Disequilibrium report for SLC35G1 (95653730 - 95715819 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SLC35G1: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SLC35G1
DNA2.0 Custom Variant and Variant Library Synthesis for SLC35G1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for SLC35G1:    About MalaCards
malaria


SLC35G1 for disorders           About GeneDecksing


Export disorders for SLC35G1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SLC35G1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SLC35G1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae. (PubMed id 21569384)1, 3 VAostermark A.8....SchiAPth H.B. (BMC Evol. Biol. 2011)
  2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 159371 HGNC: 26607 AceView: TMEM20 Ensembl:ENSG00000176273 euGenes: HUgn159371
ECgene: SLC35G1 H-InvDB: SLC35G1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SLC35G1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SLC35G1 gene:
Search GeneIP for patents involving SLC35G1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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