Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC35G1 Gene

Aliases for SLC35G1 Gene

  • Solute Carrier Family 35 Member G1 2 3 5
  • Transmembrane Protein 20 2 3 4
  • Partner Of STIM1 3 4
  • C10orf60 3 4
  • TMEM20 3 4
  • POST 3 4
  • Solute Carrier Family 35, Member G1 2

External Ids for SLC35G1 Gene

Previous HGNC Symbols for SLC35G1 Gene

  • TMEM20

Previous GeneCards Identifiers for SLC35G1 Gene

  • GC10P095653

Summaries for SLC35G1 Gene

Entrez Gene Summary for SLC35G1 Gene

  • This gene encodes a transmembrane protein which is a member of the drug/metabolite transporter protein superfamily. The encoded protein may play a role in the regulation of calcium levels inside the cell. [provided by RefSeq, Sep 2016]

GeneCards Summary for SLC35G1 Gene

SLC35G1 (Solute Carrier Family 35 Member G1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SLC35G1 Gene

  • May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35G1 Gene

Genomics for SLC35G1 Gene

Regulatory Elements for SLC35G1 Gene

Enhancers for SLC35G1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F093893 1.1 ENCODE 16.8 +2.6 2627 6.5 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS SLC35G1 PDE6C LGI1 PIPSL
GH10F093854 0.6 ENCODE 27.2 -38.0 -37963 2.9 SCRT1 JUND SCRT2 FOS PRDM1 ZKSCAN1 YY1 SLC35G1 RAB11AP1 LOC105378437
GH10F093841 0.6 ENCODE 25 -51.9 -51875 0.2 ZNF263 BCL11A POLR2A TEAD4 POU5F1 KDM1A ZKSCAN1 ETS1 SLC35G1 RAB11AP1 LOC105378437
GH10F093945 0.8 Ensembl ENCODE 15.5 +53.0 53017 2.8 ZNF680 CBX3 L3MBTL2 BHLHE40 ZBTB33 PRDM10 SLC35G1 PLCE1 PIPSL
GH10F093870 1 Ensembl ENCODE 11.4 -21.6 -21567 3.5 HDAC1 BACH1 ZNF316 GATA3 POLR2A SCRT2 NFE2 MAFK NFE2L2 RNF2 SLC35G1 RAB11AP1 LOC105378437
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35G1 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35G1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000117016 28 1600 HDGF PKNOX1 SIN3A ZNF48 ZNF2 GLIS2 ZNF263 REST TSHZ1 SMARCB1

Genomic Location for SLC35G1 Gene

Chromosome:
10
Start:
93,893,973 bp from pter
End:
93,956,062 bp from pter
Size:
62,090 bases
Orientation:
Plus strand

Genomic View for SLC35G1 Gene

Genes around SLC35G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35G1 Gene

Proteins for SLC35G1 Gene

  • Protein details for SLC35G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M3R5-S35G1_HUMAN
    Recommended name:
    Solute carrier family 35 member G1
    Protein Accession:
    Q2M3R5
    Secondary Accessions:
    • Q86YG5
    • Q8NBA5

    Protein attributes for SLC35G1 Gene

    Size:
    365 amino acids
    Molecular mass:
    39836 Da
    Quaternary structure:
    • Interacts with STIM1; stimulated by depletion of intracellular calcium. Interacts with ORAI1. Interacts with the plasma membrane calcium-transporting ATPases ATP2B1 and ATP2B4. Interacts with ATP1A1, ATP2A2, KPNB1 and XPO1.

    Alternative splice isoforms for SLC35G1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35G1 Gene

Post-translational modifications for SLC35G1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC35G1 Gene

Domains & Families for SLC35G1 Gene

Gene Families for SLC35G1 Gene

Protein Domains for SLC35G1 Gene

Suggested Antigen Peptide Sequences for SLC35G1 Gene

Graphical View of Domain Structure for InterPro Entry

Q2M3R5

UniProtKB/Swiss-Prot:

S35G1_HUMAN :
  • Contains 2 EamA domains.
  • Belongs to the TMEM20 family.
Domain:
  • Contains 2 EamA domains.
Family:
  • Belongs to the TMEM20 family.
genes like me logo Genes that share domains with SLC35G1: view

Function for SLC35G1 Gene

Molecular function for SLC35G1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell.

Gene Ontology (GO) - Molecular Function for SLC35G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22084111
genes like me logo Genes that share ontologies with SLC35G1: view

Phenotypes for SLC35G1 Gene

GenomeRNAi human phenotypes for SLC35G1:
genes like me logo Genes that share phenotypes with SLC35G1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35G1

miRNA for SLC35G1 Gene

miRTarBase miRNAs that target SLC35G1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35G1 Gene

Localization for SLC35G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35G1 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35G1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
peroxisome 2

Gene Ontology (GO) - Cellular Components for SLC35G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,IDA 22084111
GO:0005886 plasma membrane IEA,IDA 22084111
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35G1: view

Pathways & Interactions for SLC35G1 Gene

SuperPathways for SLC35G1 Gene

No Data Available

Interacting Proteins for SLC35G1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000400932%0d%0a9606.ENSP00000264705%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000304697%0d%0a9606.ENSP00000402608%0d%0a
Selected Interacting proteins: Q2M3R5-S35G1_HUMAN ENSP00000400932 for SLC35G1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SLC35G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051480 regulation of cytosolic calcium ion concentration IMP 22084111
GO:1990034 calcium ion export from cell IMP 22084111
genes like me logo Genes that share ontologies with SLC35G1: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35G1 Gene

Transcripts for SLC35G1 Gene

Unigene Clusters for SLC35G1 Gene

Solute carrier family 35, member G1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35G1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for SLC35G1 Gene

GeneLoc Exon Structure for
SLC35G1
ECgene alternative splicing isoforms for
SLC35G1

Expression for SLC35G1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC35G1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35G1 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC35G1 Gene



Protein tissue co-expression partners for SLC35G1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35G1 Gene:

SLC35G1

SOURCE GeneReport for Unigene cluster for SLC35G1 Gene:

Hs.632085

mRNA Expression by UniProt/SwissProt for SLC35G1 Gene:

Q2M3R5-S35G1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SLC35G1: view

Primer Products

No data available for mRNA differential expression in normal tissues for SLC35G1 Gene

Orthologs for SLC35G1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC35G1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM20 34 35
  • 99.73 (n)
mouse
(Mus musculus)
Mammalia Slc35g1 34 16 35
  • 81.96 (n)
dog
(Canis familiaris)
Mammalia SLC35G1 34 35
  • 80.39 (n)
rat
(Rattus norvegicus)
Mammalia Slc35g1 34
  • 79.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35G1 35
  • 74 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM20 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC35G1 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35G1 34 35
  • 73.99 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35G1 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35g1 34
  • 66.25 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100001920 34
  • 61.85 (n)
SLC35G1 35
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001214 34
  • 50.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5281 34 35
  • 49.66 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPL264C 34
  • 45.37 (n)
-- 35
  • 23 (a)
OneToMany
-- 35
  • 19 (a)
OneToMany
-- 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7107 35
  • 35 (a)
OneToMany
-- 35
  • 34 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
-- 35
  • 23 (a)
OneToMany
Species where no ortholog for SLC35G1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35G1 Gene

ENSEMBL:
Gene Tree for SLC35G1 (if available)
TreeFam:
Gene Tree for SLC35G1 (if available)

Paralogs for SLC35G1 Gene

(1) SIMAP similar genes for SLC35G1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC35G1: view

No data available for Paralogs for SLC35G1 Gene

Variants for SLC35G1 Gene

Sequence variations from dbSNP and Humsavar for SLC35G1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs144043787 Uncertain significance 93,900,819(+) CTACC(A/G)CCATG intron-variant, reference, missense
rs1046414 -- 93,909,658(-) ATTTT(A/G)TAATG intron-variant, nc-transcript-variant
rs10633818 -- 93,903,955(+) ACTGT(-/TTGT)CTGAC intron-variant, downstream-variant-500B
rs10691999 -- 93,903,952(+) TAAAC(-/TGTT)TGTCT intron-variant, downstream-variant-500B
rs10786148 -- 93,895,809(+) TCTCC(A/T)TACTT intron-variant

Variation tolerance for SLC35G1 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35G1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35G1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC35G1 Gene

Disorders for SLC35G1 Gene

Relevant External Links for SLC35G1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35G1

No disorders were found for SLC35G1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35G1 Gene

Publications for SLC35G1 Gene

  1. Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae. (PMID: 21569384) VAostermark A.8. … SchiAPth H.B. (BMC Evol. Biol. 2011) 2 3 64
  2. POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. (PMID: 22084111) Krapivinsky G. … Clapham D.E. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SLC35G1 Gene

Sources for SLC35G1 Gene

Content
Loading form....