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Aliases for SLC35F6 Gene

Aliases for SLC35F6 Gene

  • Solute Carrier Family 35 Member F6 2 3 5
  • ANT2-Binding Protein 2 3 4
  • Transport And Golgi Organization 9 Homolog 3 4
  • Solute Carrier Family 35, Member F6 2 3
  • C2orf18 3 4
  • ANT2BP 3 4
  • Transport And Golgi Organization 9 Homolog (Drosophila) 2
  • Chromosome 2 Open Reading Frame 18 2
  • Transmembrane Protein C2orf18 3
  • TANGO9 3

External Ids for SLC35F6 Gene

Previous HGNC Symbols for SLC35F6 Gene

  • C2orf18

Previous GeneCards Identifiers for SLC35F6 Gene

  • GC02P026989

Summaries for SLC35F6 Gene

GeneCards Summary for SLC35F6 Gene

SLC35F6 (Solute Carrier Family 35 Member F6) is a Protein Coding gene. Diseases associated with SLC35F6 include pancreatic ductal adenocarcinoma. GO annotations related to this gene include sugar:proton symporter activity.

UniProtKB/Swiss-Prot for SLC35F6 Gene

  • Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.

Gene Wiki entry for SLC35F6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35F6 Gene

Genomics for SLC35F6 Gene

Regulatory Elements for SLC35F6 Gene

Promoters for SLC35F6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC35F6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35F6 Gene

Chromosome:
2
Start:
26,764,274 bp from pter
End:
26,781,231 bp from pter
Size:
16,958 bases
Orientation:
Plus strand

Genomic View for SLC35F6 Gene

Genes around SLC35F6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35F6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35F6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35F6 Gene

Proteins for SLC35F6 Gene

  • Protein details for SLC35F6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N357-S35F6_HUMAN
    Recommended name:
    Solute carrier family 35 member F6
    Protein Accession:
    Q8N357
    Secondary Accessions:
    • D6W543
    • Q53GK2
    • Q8NBX6
    • Q9NWX0

    Protein attributes for SLC35F6 Gene

    Size:
    371 amino acids
    Molecular mass:
    40214 Da
    Quaternary structure:
    • Interacts with SLC25A5.

neXtProt entry for SLC35F6 Gene

Proteomics data for SLC35F6 Gene at MOPED

Post-translational modifications for SLC35F6 Gene

Other Protein References for SLC35F6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35F6 Gene

Domains & Families for SLC35F6 Gene

Protein Domains for SLC35F6 Gene

Suggested Antigen Peptide Sequences for SLC35F6 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N357

UniProtKB/Swiss-Prot:

S35F6_HUMAN :
  • Contains 1 EamA domain.
  • Belongs to the SLC35F solute transporter family.
Domain:
  • Contains 1 EamA domain.
Family:
  • Belongs to the SLC35F solute transporter family.
genes like me logo Genes that share domains with SLC35F6: view

No data available for Gene Families for SLC35F6 Gene

Function for SLC35F6 Gene

Molecular function for SLC35F6 Gene

UniProtKB/Swiss-Prot Function:
Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.
genes like me logo Genes that share phenotypes with SLC35F6: view

Animal Models for SLC35F6 Gene

MGI Knock Outs for SLC35F6:

Animal Model Products

CRISPR Products

miRNA for SLC35F6 Gene

miRTarBase miRNAs that target SLC35F6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC35F6 Gene

Localization for SLC35F6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35F6 Gene

Mitochondrion. Lysosome membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SLC35F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC35F6: view

No data available for Subcellular locations from COMPARTMENTS for SLC35F6 Gene

Pathways & Interactions for SLC35F6 Gene

SuperPathways for SLC35F6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SLC35F6: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35F6 Gene

Drugs & Compounds for SLC35F6 Gene

No Compound Related Data Available

Transcripts for SLC35F6 Gene

Unigene Clusters for SLC35F6 Gene

Solute carrier family 35, member F6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35F6 Gene

No ASD Table

Relevant External Links for SLC35F6 Gene

GeneLoc Exon Structure for
SLC35F6
ECgene alternative splicing isoforms for
SLC35F6

Expression for SLC35F6 Gene

mRNA expression in normal human tissues for SLC35F6 Gene

Protein differential expression in normal tissues from HIPED for SLC35F6 Gene

This gene is overexpressed in Nasal epithelium (45.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC35F6 Gene



SOURCE GeneReport for Unigene cluster for SLC35F6 Gene Hs.516034

mRNA Expression by UniProt/SwissProt for SLC35F6 Gene

Q8N357-S35F6_HUMAN
Tissue specificity: Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in prostate and thyroid. Weakly expressed in lung, heart, liver and kidney.
genes like me logo Genes that share expression patterns with SLC35F6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for SLC35F6 Gene

Orthologs for SLC35F6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC35F6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C11H2orf18 35
  • 90.21 (n)
  • 94.07 (a)
MGC139367 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C17H2orf18 35
  • 90.03 (n)
  • 93.53 (a)
SLC35F6 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35f6 35
  • 85.8 (n)
  • 87.06 (a)
Slc35f6 16
Slc35f6 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf18 35
  • 99.37 (n)
  • 99.73 (a)
SLC35F6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35f6 35
  • 87.15 (n)
  • 88.41 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC35F6 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35F6 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2ORF18 35
  • 78.86 (n)
  • 80.76 (a)
SLC35F6 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35F6 36
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sbcb433 35
slc35f6 35
  • 68.57 (n)
  • 74.46 (a)
slc35f6 36
  • 73 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3488 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003549 35
  • 58.31 (n)
  • 55.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tango9 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C29H12.2 35
  • 56.31 (n)
  • 55.38 (a)
C29H12.2 36
  • 47 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C04433g 35
  • 44.27 (n)
  • 35.05 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4383 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00025 35
  • 53.6 (n)
  • 39.82 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC12G12.12 35
  • 43.95 (n)
  • 35.96 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11327 36
  • 57 (a)
OneToOne
Species with no ortholog for SLC35F6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC35F6 Gene

ENSEMBL:
Gene Tree for SLC35F6 (if available)
TreeFam:
Gene Tree for SLC35F6 (if available)

Paralogs for SLC35F6 Gene

(1) SIMAP similar genes for SLC35F6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC35F6: view

No data available for Paralogs for SLC35F6 Gene

Variants for SLC35F6 Gene

Sequence variations from dbSNP and Humsavar for SLC35F6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs828254 -- 26,763,011(+) TTCCC(C/G)TTTCC upstream-variant-2KB
rs828255 -- 26,763,923(+) TTAGC(C/T)GGGCG upstream-variant-2KB
rs828259 -- 26,767,639(+) TGTCT(A/G)CGTGA intron-variant
rs828260 -- 26,769,395(+) ACAGT(A/G)TCTGT intron-variant
rs828261 -- 26,769,503(+) CATGA(C/G)TGCCT intron-variant

Variation tolerance for SLC35F6 Gene

Residual Variation Intolerance Score: 19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35F6 Gene

HapMap Linkage Disequilibrium report
SLC35F6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC35F6 Gene

Disorders for SLC35F6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC35F6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC35F6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35F6
genes like me logo Genes that share disorders with SLC35F6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35F6 Gene

Publications for SLC35F6 Gene

  1. Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis. (PMID: 19154410) Kashiwaya K. … Nakagawa H. (Cancer Sci. 2009) 2 3 4 67
  2. The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP- N-acetylglucosamine. (PMID: 15911612) Ashikov A. … Bakker H. (J. Biol. Chem. 2005) 2 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. ErbB2-associated changes in the lysosomal proteome. (PMID: 21674799) Nylandsted J. … JAoAottelAo M. (Proteomics 2011) 3
  5. The proteome of lysosomes. (PMID: 20957757) Schroeder B.A. … Saftig P. (Proteomics 2010) 3

Products for SLC35F6 Gene

Sources for SLC35F6 Gene

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