SLC35F6 Gene
protein-coding GIFtS: 42
GCID: GC02P026989
|
|
Solute Carrier Family 35, Member F6(Previous name: chromosome 2 open reading frame 18)
(Previous symbol: C2orf18)
| |
Aliases
for SLC35F6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| Solute Carrier Family 35, Member F61 2 | | Chromosome 2 Open Reading Frame 181 | | C2orf181 2 3 | | Transport And Golgi Organization 9 Homolog (Drosophila)1 | | ANT2-Binding Protein1 2 3 | | TANGO92 | | Transport And Golgi Organization 9 Homolog2 3 | | Solute Carrier Family 35 Member F62 | | ANT2BP2 3 | | Transmembrane Protein C2orf182 |
Export aliases for SLC35F6 gene to outside databases |
Summaries
for SLC35F6 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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GeneCards Summary for SLC35F6 Gene:
SLC35F6 (solute carrier family 35, member F6) is a protein-coding gene. Diseases associated with SLC35F6 include pancreatic ductal adenocarcinoma, and pancreatitis.
UniProtKB/Swiss-Prot: S35F6_HUMAN, Q8N357Function: Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma
(PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar
transporter
Gene Wiki entry for SLC35F6 (C2orf18) Gene
|
Genomic Views
for SLC35F6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000002.12 NC_018913.2 NT_022184.16
Regulatory elements:
 Search for regulatory transcription factor binding sites for SLC35F6
Other transcription factors
Search Chromatin IP Primers for SLC35F6
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC35F6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p24.1SLC35F6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P026989: view genomic region
(about GC identifiers)
Start:
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26,987,142 bp from pter |
End:
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27,004,099 bp from pter |
Size:
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16,958 bases |
Orientation:
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plus strand |
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Proteins
for SLC35F6 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB/Swiss-Prot: S35F6_HUMAN, Q8N357 (See
protein sequence)Recommended Name: Solute carrier family 35 member F6 precursor Size: 371 amino acids; 40214 Da
Subunit: Interacts with SLC25A5
Secondary accessions: D6W543 Q53GK2 Q8NBX6 Q9NWX0Explore the universe of human proteins at neXtProt for SLC35F6: NX_Q8N357
Explore proteomics data for SLC35F6 at MOPED
Post-translational modifications:  Ubiquitination2 at Lys203 Glycosylation2 at Asn110 Modification sites at PhosphoSitePlus
See SLC35F6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins: NP_060347.2
ENSEMBL proteins: ENSP00000397623 ENSP00000345528 ENSP00000396256 ENSP00000413413
SLC35F6 Human Recombinant
Protein Products:SLC35F6 Antibody
Products:SLC35F6 Assay Products: |
Domains /
Families
for SLC35F6 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | 2 InterPro protein domains:Graphical View of Domain Structure for InterPro Entry Q8N357 ProtoNet protein and cluster: Q8N357 1 Blocks protein domain: IPB000620 Protein of unknown function DUF6
UniProtKB/Swiss-Prot: S35F6_HUMAN, Q8N357Similarity: Belongs to the SLC35F solute transporter familySimilarity: Contains 1 EamA domain
SLC35F6 for domains About GeneDecksing
|
Function
for SLC35F6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
About This Section
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Molecular Function:
UniProtKB/Swiss-Prot Summary: S35F6_HUMAN, Q8N357Function: Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma
(PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar
transporter Gene Ontology (GO): 2 molecular function terms: About this table
SLC35F6 for ontologies About GeneDecksing
Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Slc35f6):
SLC35F6 for phenotypes About GeneDecksing
Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for SLC35F6
| | | Predesigned siRNA for gene silencing in human, mouse, rat SLC35F6 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for SLC35F6 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for SLC35F6  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35F6 |
Localization
for SLC35F6 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot S35F6_HUMAN, Q8N357: Mitochondrion. Lysosome membrane; Multi-pass membrane proteinGene Ontology (GO): Selected cellular component terms (see all 11): About this table
SLC35F6 for ontologies About GeneDecksing
|
Pathways & Interactions
for SLC35F6 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
About This Section
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC35F6
Interactions:
Search GeneGlobe Interaction Network for SLC35F6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
Selected Interacting proteins for SLC35F6 (Q8N3571, 2, 3 ENSP000003455284) via UniProtKB, MINT, STRING, and/or I2D (see all 38)About this table
Gene Ontology (GO): 5 biological process terms: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- | | GO:0008284 | positive regulation of cell proliferation |
IMP | 19154410 | | GO:0008643 | carbohydrate transport |
-- | -- | | GO:0055085 | transmembrane transport |
-- | -- | | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
IMP | 19154410 |
SLC35F6 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC35F6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for SLC35F6 (S35F6)
|
Transcripts
for SLC35F6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for SLC35F6 gene: NM_017877.3 Unigene Cluster for SLC35F6: Solute carrier family 35, member F6 Hs.516034 [show with all ESTs]Unigene Representative Sequence: NM_0178775 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000429494 ENST00000344420(uc002rhp.1 uc002rhq.1 uc010eyo.1 uc010ylc.1)
ENST00000482746 ENST00000414029 ENST00000416475
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for SLC35F6
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat SLC35F6 |
Additional mRNA sequence: AK000562.1 AK025889.1 AK075164.1 AK222929.1 AK296996.1 AK299598.1 AY358820.1 BC005887.2 BC016389.1 BC028081.1 BC035519.1 BX647807.1 BX648017.1 CR457243.1 7 DOTS entries: DT.100776981 DT.100776979 DT.91688975 DT.121020530 DT.87006882 DT.95162633 DT.95365836 Selected AceView cDNA sequences (see all 235): BC028081 AA742587 BU501174 AI263576 BM698794 CR623149 CR626752 AI202608 AI804106 AI784079 BM990454 NM_001809 BX108564 BM721691 CR595898 BM677286 BM849011 BQ009148 BX648017 AA554281 BG058706 AW594214 AY358820 AI369629
GeneLoc Exon Structure
|
Expression
for SLC35F6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
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SLC35F6 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
About this image SLC35F6 Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
SOURCE GeneReport for Unigene cluster: Hs.516034
UniProtKB/Swiss-Prot: S35F6_HUMAN, Q8N357Tissue specificity: Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in
prostate and thyroid. Weakly expressed in lung, heart, liver and kidney
Custom PCR Arrays for SLC35F6
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for SLC35F6
| | | Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat SLC35F6 | | | QuantiTect SYBR Green Assays in human, mouse, rat SLC35F6 | | | QuantiFast Probe-based Assays in human, mouse, rat SLC35F6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35F6 |
Orthologs
for SLC35F6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals and fungi.
Orthologs for SLC35F6 gene from Selected species (see all 19) About this table
ENSEMBL Gene Tree for SLC35F6 (if available)
TreeFam Gene Tree for SLC35F6 (if available) |
Paralogs
for SLC35F6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for SLC35F6 gene
1 SIMAP similar gene for SLC35F6 using alignment to 3 protein entries: S35F6_HUMAN (see all proteins):C2orf18
SLC35F6 for paralogs About GeneDecksing
|
Genomic Variants
for SLC35F6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC35F6 (26987142 - 27004099 bp)
Structural Variations
Database of Genomic Variants (DGV) variations for SLC35F6: --
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing SLC35F6 |
|
Disorders
/ Diseases
for SLC35F6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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6  diseases for SLC35F6:
About MalaCardspancreatic ductal adenocarcinoma pancreatitis adenocarcinoma thyroiditis
malaria prostatitis
SLC35F6 for disorders About GeneDecksing
Export disorders for SLC35F6 gene to outside databases
|
Publications
for SLC35F6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for SLC35F6 gene, integrated from 10 sources (see all 22):
(articles sorted by number of sources associating them with SLC35F6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis. (PubMed id 19154410)1, 2, 3 Kashiwaya K.... Nakagawa H. (Cancer Sci. 2009)
- The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP- N-acetylglucosamine. (PubMed id 15911612)1, 3 Ashikov A.... Bakker H. (J. Biol. Chem. 2005)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
- Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
- A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
|
External Searches for SLC35F6 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing SLC35F6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing SLC35F6 gene
(According to HUGE)
About This Section
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Specialized Databases showing SLC35F6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for SLC35F6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for SLC35F6 gene:
Search GeneIP for patents involving SLC35F6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SLC35F6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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 | |
 |
| | | | |
 |
 |
|  | Block miRNA regulation of human, mouse, rat SLC35F6 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing SLC35F6 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC35F6 | | Predesigned siRNA for gene silencing in human, mouse, rat SLC35F6 | | | QuantiFast Probe-based Assays in human, mouse, rat SLC35F6 | | QuantiTect SYBR Green Assays in human, mouse, rat SLC35F6 | | | Custom PCR Arrays for SLC35F6 | | Search Chromatin IP Primers for SLC35F6 | | | Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SLC35F6 | | Search GeneGlobe Interaction Network for SLC35F6 | | | Search Regulatory tfbs for SLC35F6 |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35F6 |
| |  |  |  |  | | | ThermoFisher Antibodies for SLC35F6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35F6 |
| | | | LSBio Antibodies in human, mouse, rat for SLC35F6 |
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