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Aliases for SLC35F6 Gene

Aliases for SLC35F6 Gene

  • Solute Carrier Family 35, Member F6 2 3
  • ANT2-Binding Protein 2 3 4
  • Transport And Golgi Organization 9 Homolog 3 4
  • C2orf18 3 4
  • ANT2BP 3 4
  • Transport And Golgi Organization 9 Homolog (Drosophila) 2
  • Chromosome 2 Open Reading Frame 18 2
  • Solute Carrier Family 35 Member F6 3
  • Transmembrane Protein C2orf18 3
  • TANGO9 3

External Ids for SLC35F6 Gene

Previous HGNC Symbols for SLC35F6 Gene

  • C2orf18

Previous GeneCards Identifiers for SLC35F6 Gene

  • GC02P026989

Summaries for SLC35F6 Gene

GeneCards Summary for SLC35F6 Gene

SLC35F6 (Solute Carrier Family 35, Member F6) is a Protein Coding gene. Diseases associated with SLC35F6 include pancreatic ductal adenocarcinoma.

UniProtKB/Swiss-Prot for SLC35F6 Gene

  • Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.

Gene Wiki entry for SLC35F6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35F6 Gene

Genomics for SLC35F6 Gene

Genomic Location for SLC35F6 Gene

Start:
26,764,274 bp from pter
End:
26,781,231 bp from pter
Size:
16,958 bases
Orientation:
Plus strand

Genomic View for SLC35F6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC35F6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35F6 Gene

No data available for Regulatory Elements for SLC35F6 Gene

Proteins for SLC35F6 Gene

  • Protein details for SLC35F6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N357-S35F6_HUMAN
    Recommended name:
    Solute carrier family 35 member F6
    Protein Accession:
    Q8N357
    Secondary Accessions:
    • D6W543
    • Q53GK2
    • Q8NBX6
    • Q9NWX0

    Protein attributes for SLC35F6 Gene

    Size:
    371 amino acids
    Molecular mass:
    40214 Da
    Quaternary structure:
    • Interacts with SLC25A5.

neXtProt entry for SLC35F6 Gene

Proteomics data for SLC35F6 Gene at MOPED

Post-translational modifications for SLC35F6 Gene

Other Protein References for SLC35F6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35F6 Gene

Domains for SLC35F6 Gene

Protein Domains for SLC35F6 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N357

UniProtKB/Swiss-Prot:

S35F6_HUMAN :
  • Q8N357
Domain:
  • Contains 1 EamA domain.
Family:
  • Belongs to the SLC35F solute transporter family.
genes like me logo Genes that share domains with SLC35F6: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SLC35F6 Gene

Function for SLC35F6 Gene

Molecular function for SLC35F6 Gene

UniProtKB/Swiss-Prot Function: Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.

Gene Ontology (GO) - Molecular Function for SLC35F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity --
GO:0005515 protein binding IPI 19154410
genes like me logo Genes that share ontologies with SLC35F6: view

Phenotypes for SLC35F6 Gene

genes like me logo Genes that share phenotypes with SLC35F6: view

miRNA for SLC35F6 Gene

miRTarBase miRNAs that target SLC35F6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC35F6 Gene

Localization for SLC35F6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35F6 Gene

Mitochondrion. Lysosome membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SLC35F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane --
GO:0005739 mitochondrion IDA 19154410
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IDA 17897319
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SLC35F6: view

No data available for Subcellular locations from COMPARTMENTS for SLC35F6 Gene

Pathways for SLC35F6 Gene

SuperPathways for SLC35F6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008284 positive regulation of cell proliferation IMP 19154410
GO:0008643 carbohydrate transport --
GO:0055085 transmembrane transport --
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IMP 19154410
genes like me logo Genes that share ontologies with SLC35F6: view

No data available for Pathways by source for SLC35F6 Gene

Transcripts for SLC35F6 Gene

Unigene Clusters for SLC35F6 Gene

Solute carrier family 35, member F6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35F6 Gene

No ASD Table

Relevant External Links for SLC35F6 Gene

GeneLoc Exon Structure for
SLC35F6
ECgene alternative splicing isoforms for
SLC35F6

Expression for SLC35F6 Gene

mRNA expression in normal human tissues for SLC35F6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC35F6 Gene

SOURCE GeneReport for Unigene cluster for SLC35F6 Gene Hs.516034

mRNA Expression by UniProt/SwissProt for SLC35F6 Gene

Q8N357-S35F6_HUMAN
Tissue specificity: Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in prostate and thyroid. Weakly expressed in lung, heart, liver and kidney.
genes like me logo Genes that share expressions with SLC35F6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC35F6 Gene

Orthologs for SLC35F6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC35F6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf18 35
  • 99.37 (n)
  • 99.73 (a)
SLC35F6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11H2orf18 35
  • 90.21 (n)
  • 94.07 (a)
MGC139367 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C17H2orf18 35
  • 90.03 (n)
  • 93.53 (a)
SLC35F6 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35f6 35
  • 85.8 (n)
  • 87.06 (a)
Slc35f6 16
Slc35f6 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC35F6 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35F6 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35f6 35
  • 87.15 (n)
  • 88.41 (a)
chicken
(Gallus gallus)
Aves C2ORF18 35
  • 78.86 (n)
  • 80.76 (a)
SLC35F6 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35F6 36
  • 76 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3488 35
zebrafish
(Danio rerio)
Actinopterygii sbcb433 35
slc35f6 35
  • 68.57 (n)
  • 74.46 (a)
slc35f6 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003549 35
  • 58.31 (n)
  • 55.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tango9 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C29H12.2 35
  • 56.31 (n)
  • 55.38 (a)
C29H12.2 36
  • 47 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C04433g 35
  • 44.27 (n)
  • 35.05 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00025 35
  • 53.6 (n)
  • 39.82 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC12G12.12 35
  • 43.95 (n)
  • 35.96 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4383 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11327 36
  • 57 (a)
OneToOne
Species with no ortholog for SLC35F6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC35F6 Gene

ENSEMBL:
Gene Tree for SLC35F6 (if available)
TreeFam:
Gene Tree for SLC35F6 (if available)

Paralogs for SLC35F6 Gene

Selected SIMAP similar genes for SLC35F6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC35F6: view

No data available for Paralogs for SLC35F6 Gene

Variants for SLC35F6 Gene

Sequence variations from dbSNP and Humsavar for SLC35F6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs828254 -- 26,763,011(+) TTCCC(C/G)TTTCC upstream-variant-2KB
rs828255 -- 26,763,923(+) TTAGC(C/T)GGGCG upstream-variant-2KB
rs828259 -- 26,767,639(+) TGTCT(A/G)CGTGA intron-variant
rs828260 -- 26,769,395(+) ACAGT(A/G)TCTGT intron-variant
rs828261 -- 26,769,503(+) CATGA(C/G)TGCCT intron-variant

Relevant External Links for SLC35F6 Gene

HapMap Linkage Disequilibrium report
SLC35F6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC35F6 Gene

Disorders for SLC35F6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC35F6 Gene including...

Search for SLC35F6 Gene in MalaCards »
genes like me logo Genes that share disorders with SLC35F6: view

No data available for UniProtKB/Swiss-Prot for SLC35F6 Gene

Publications for SLC35F6 Gene

  1. Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis. (PMID: 19154410) Kashiwaya K. … Nakagawa H. (Cancer Sci. 2009) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for SLC35F6 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SLC35F6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SLC35F6
    • Block miRNA regulation of SLC35F6 using miScript Target Protectors
    • antibodies-online peptides for SLC35F6
    • antibodies-online antibodies for SLC35F6
    • antibodies-online kits for SLC35F6

    Sources for SLC35F6 Gene

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