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Aliases for SLC35F6 Gene

Aliases for SLC35F6 Gene

  • Solute Carrier Family 35 Member F6 2 3 5
  • ANT2-Binding Protein 2 3 4
  • Transport And Golgi Organization 9 Homolog 3 4
  • C2orf18 3 4
  • ANT2BP 3 4
  • Transport And Golgi Organization 9 Homolog (Drosophila) 2
  • Solute Carrier Family 35, Member F6 2
  • Chromosome 2 Open Reading Frame 18 2
  • Transmembrane Protein C2orf18 3
  • TANGO9 3

External Ids for SLC35F6 Gene

Previous HGNC Symbols for SLC35F6 Gene

  • C2orf18

Previous GeneCards Identifiers for SLC35F6 Gene

  • GC02P026989

Summaries for SLC35F6 Gene

GeneCards Summary for SLC35F6 Gene

SLC35F6 (Solute Carrier Family 35 Member F6) is a Protein Coding gene. Diseases associated with SLC35F6 include Pancreatic Ductal Adenocarcinoma. GO annotations related to this gene include sugar:proton symporter activity.

UniProtKB/Swiss-Prot for SLC35F6 Gene

  • Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.

Gene Wiki entry for SLC35F6 Gene

Additional gene information for SLC35F6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35F6 Gene

Genomics for SLC35F6 Gene

Regulatory Elements for SLC35F6 Gene

Enhancers for SLC35F6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H026717 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 12 -42.0 -42020 10.1 HDGF FOXA2 MLX SIN3A DMAP1 YY1 ZNF766 FOS SP5 REST EIF2B4 GPN1 CAD NRBP1 GTF3C2-AS1 ASXL2 CENPA LOC105374363 KCNK3 TMEM214
GH02H026011 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10 -751.7 -751718 3 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 YY1 FOS DEK SP3 RAB10 RNU6-942P KIF3C SLC35F6 GAREM2 TRMT112P6 GC02P025994
GH02H026032 1.8 FANTOM5 ENCODE dbSUPER 10 -729.8 -729787 4.4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 RAB10 SLC35F6 GAREM2 GC02P026043
GH02H026342 1.4 ENCODE dbSUPER 10 -418.5 -418505 6.3 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CAD GTF3C2-AS1 ASXL2 ENSG00000272148 AGBL5 KIF3C GAREM2 ADGRF3 AGBL5-IT1 ENSG00000272056
GH02H027122 1 ENCODE 5.3 +359.4 359392 1.7 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 YY1 ATF7 SP3 SP5 TCF23 ATRAID SLC5A6 KHK EMILIN1 CAD CENPA SLC35F6 CGREF1 ABHD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35F6 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35F6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114324 226 1401 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF207 FOS SP3 SP5

Genomic Locations for SLC35F6 Gene

Genomic Locations for SLC35F6 Gene
chr2:26,764,274-26,781,231
(GRCh38/hg38)
Size:
16,958 bases
Orientation:
Plus strand
chr2:26,987,142-27,004,099
(GRCh37/hg19)

Genomic View for SLC35F6 Gene

Genes around SLC35F6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35F6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35F6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35F6 Gene

Proteins for SLC35F6 Gene

  • Protein details for SLC35F6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N357-S35F6_HUMAN
    Recommended name:
    Solute carrier family 35 member F6
    Protein Accession:
    Q8N357
    Secondary Accessions:
    • D6W543
    • Q53GK2
    • Q8NBX6
    • Q9NWX0

    Protein attributes for SLC35F6 Gene

    Size:
    371 amino acids
    Molecular mass:
    40214 Da
    Quaternary structure:
    • Interacts with SLC25A5.

neXtProt entry for SLC35F6 Gene

Post-translational modifications for SLC35F6 Gene

  • Ubiquitination at isoforms=203
  • Glycosylation at Asn110
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC35F6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35F6 Gene

Domains & Families for SLC35F6 Gene

Gene Families for SLC35F6 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35F6 Gene

Suggested Antigen Peptide Sequences for SLC35F6 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N357

UniProtKB/Swiss-Prot:

S35F6_HUMAN :
  • Belongs to the SLC35F solute transporter family.
Family:
  • Belongs to the SLC35F solute transporter family.
genes like me logo Genes that share domains with SLC35F6: view

Function for SLC35F6 Gene

Molecular function for SLC35F6 Gene

UniProtKB/Swiss-Prot Function:
Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.

Phenotypes From GWAS Catalog for SLC35F6 Gene

Gene Ontology (GO) - Molecular Function for SLC35F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19154410
genes like me logo Genes that share ontologies with SLC35F6: view
genes like me logo Genes that share phenotypes with SLC35F6: view

Animal Models for SLC35F6 Gene

MGI Knock Outs for SLC35F6:

Animal Model Products

CRISPR Products

miRNA for SLC35F6 Gene

miRTarBase miRNAs that target SLC35F6

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC35F6 Gene

Localization for SLC35F6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35F6 Gene

Mitochondrion. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35F6 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 5
lysosome 5
plasma membrane 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC35F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA,IDA 19154410
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA,IDA 17897319
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SLC35F6: view

Pathways & Interactions for SLC35F6 Gene

SuperPathways for SLC35F6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008284 positive regulation of cell proliferation IMP 19154410
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IMP 19154410
genes like me logo Genes that share ontologies with SLC35F6: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35F6 Gene

Drugs & Compounds for SLC35F6 Gene

No Compound Related Data Available

Transcripts for SLC35F6 Gene

Unigene Clusters for SLC35F6 Gene

Solute carrier family 35, member F6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35F6 Gene

No ASD Table

Relevant External Links for SLC35F6 Gene

GeneLoc Exon Structure for
SLC35F6
ECgene alternative splicing isoforms for
SLC35F6

Expression for SLC35F6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35F6 Gene

Protein differential expression in normal tissues from HIPED for SLC35F6 Gene

This gene is overexpressed in Nasal epithelium (45.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC35F6 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC35F6 Gene:

SLC35F6

SOURCE GeneReport for Unigene cluster for SLC35F6 Gene:

Hs.516034

mRNA Expression by UniProt/SwissProt for SLC35F6 Gene:

Q8N357-S35F6_HUMAN
Tissue specificity: Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in prostate and thyroid. Weakly expressed in lung, heart, liver and kidney.

Evidence on tissue expression from TISSUES for SLC35F6 Gene

  • Kidney(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with SLC35F6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35F6 Gene

Orthologs for SLC35F6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC35F6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35F6 34
  • 100 (a)
OneToOne
C2AH2orf18 33
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia MGC139367 34
  • 94 (a)
OneToOne
C11H2orf18 33
  • 90.21 (n)
dog
(Canis familiaris)
Mammalia SLC35F6 34
  • 94 (a)
OneToOne
C17H2orf18 33
  • 90.03 (n)
rat
(Rattus norvegicus)
Mammalia Slc35f6 33
  • 87.15 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC35F6 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35F6 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35f6 33 16 34
  • 85.8 (n)
chicken
(Gallus gallus)
Aves SLC35F6 34
  • 80 (a)
OneToOne
C2ORF18 33
  • 78.86 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35F6 34
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc35f6 33 34
  • 68.57 (n)
sbcb433 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3488 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003549 33
  • 58.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tango9 34
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C29H12.2 33 34
  • 56.31 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C04433g 33
  • 44.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11327 34
  • 57 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00025 33
  • 53.6 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC12G12.12 33
  • 43.95 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4383 33
Species where no ortholog for SLC35F6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC35F6 Gene

ENSEMBL:
Gene Tree for SLC35F6 (if available)
TreeFam:
Gene Tree for SLC35F6 (if available)

Paralogs for SLC35F6 Gene

(1) SIMAP similar genes for SLC35F6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC35F6: view

No data available for Paralogs for SLC35F6 Gene

Variants for SLC35F6 Gene

Sequence variations from dbSNP and Humsavar for SLC35F6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000025449 -- 26,770,575(+) TAGCT(A/G)GGCAT intron-variant
rs1000124742 -- 26,770,306(+) GAGGC(G/T)GAGGT intron-variant
rs1000255062 -- 26,776,877(+) GGACT(A/G)GATGT intron-variant
rs1000382162 -- 26,781,323(+) AAGGG(A/G)AAGCA downstream-variant-500B
rs1000558987 -- 26,774,888(+) GCTGT(-/CTCTA)CTCTA intron-variant

Variation tolerance for SLC35F6 Gene

Residual Variation Intolerance Score: 19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35F6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35F6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC35F6 Gene

Disorders for SLC35F6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC35F6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC35F6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35F6
genes like me logo Genes that share disorders with SLC35F6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35F6 Gene

Publications for SLC35F6 Gene

  1. Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis. (PMID: 19154410) Kashiwaya K … Nakagawa H (Cancer science 2009) 2 3 4 60
  2. The proteome of lysosomes. (PMID: 20957757) Schröder BA … Saftig P (Proteomics 2010) 3 4 60
  3. The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine. (PMID: 15911612) Ashikov A … Bakker H (The Journal of biological chemistry 2005) 2 3 60
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60

Products for SLC35F6 Gene

Sources for SLC35F6 Gene

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