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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC35F6 Gene

protein-coding   GIFtS: 41
GCID: GC02P026989

Solute Carrier Family 35, Member F6

(Previous name: chromosome 2 open reading frame 18)
(Previous symbol: C2orf18)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 35, Member F61 2     Chromosome 2 Open Reading Frame 181
C2orf181 2 3     Transport And Golgi Organization 9 Homolog (Drosophila)1
ANT2-Binding Protein1 2 3     TANGO92
Transport And Golgi Organization 9 Homolog2 3     Solute Carrier Family 35 Member F62
ANT2BP2 3     Transmembrane Protein C2orf182

External Ids:    HGNC: 260551   Entrez Gene: 549782   Ensembl: ENSG000002136997   UniProtKB: Q8N3573   

Export aliases for SLC35F6 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC35F6 Gene: 
SLC35F6 (solute carrier family 35, member F6) is a protein-coding gene. Diseases associated with SLC35F6 include pancreatic ductal adenocarcinoma, and thyroiditis. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: S35F6_HUMAN, Q8N357
Function: Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma
(PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar
transporter

Gene Wiki entry for SLC35F6 (C2orf18) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SLC35F6
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC35F6 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC35F6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35F6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p24.1

SLC35F6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35F6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P026989:  view genomic region     (about GC identifiers)

Start:
26,987,142 bp from pter      End:
27,004,099 bp from pter
Size:
16,958 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S35F6_HUMAN, Q8N357 (See protein sequence)
Recommended Name: Solute carrier family 35 member F6 precursor  
Size: 371 amino acids; 40214 Da
Subunit: Interacts with SLC25A5
Subcellular location: Mitochondrion. Lysosome membrane; Multi-pass membrane protein
Secondary accessions: D6W543 Q53GK2 Q8NBX6 Q9NWX0

Explore the universe of human proteins at neXtProt for SLC35F6: NX_Q8N357

Explore proteomics data for SLC35F6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N357

  • SLC35F6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC35F6 Protein Expression
    REFSEQ proteins: NP_060347.2  
    ENSEMBL proteins: 
     ENSP00000397623   ENSP00000345528   ENSP00000396256   ENSP00000413413  

    Human Recombinant Protein Products for SLC35F6: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA19154410

    SLC35F6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR012404 UCP036436
     IPR009262 DUF914_euk

    Graphical View of Domain Structure for InterPro Entry Q8N357

    ProtoNet protein and cluster: Q8N357

    1 Blocks protein domain: IPB000620 Protein of unknown function DUF6

    UniProtKB/Swiss-Prot: S35F6_HUMAN, Q8N357
    Similarity: Belongs to the SLC35F solute transporter family
    Similarity: Contains 1 EamA domain


    SLC35F6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S35F6_HUMAN, Q8N357
    Function: Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma
    (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar
    transporter

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005351sugar:hydrogen symporter activity ----
    GO:0005515protein binding IPI19154410
         
    SLC35F6 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc35f6):
     pigmentation  vision/eye 

    SLC35F6 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35F6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/35 Interacting proteins for SLC35F6 (Q8N3571, 2, 3 ENSP000003455284) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MS4A7Q9GZW82, 3, ENSP000003001844MINT-65434 I2D: score=5 STRING: ENSP00000300184
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202195 I2D: score=1 STRING: ENSP00000250416
    ACP5P136862, 3MINT-63469 I2D: score=5 
    ALDH2P050912, 3MINT-63388 I2D: score=5 
    NDUFA4L2Q9NRX32, 3MINT-65624 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0008284positive regulation of cell proliferation IMP19154410
    GO:0008643carbohydrate transport ----
    GO:0055085transmembrane transport ----
    GO:1901029negative regulation of mitochondrial outer membrane permeabilization IMP19154410

    SLC35F6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC35F6 (S35F6)

    Search CenterWatch for drugs/clinical trials and news about SLC35F6 / S35F6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC35F6 gene: 
    NM_017877.3  

    Unigene Cluster for SLC35F6:

    Solute carrier family 35, member F6
    Hs.516034  [show with all ESTs]
    Unigene Representative Sequence: NM_017877
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429494 ENST00000344420(uc002rhp.1 uc002rhq.1 uc010eyo.1 uc010ylc.1)
    ENST00000482746 ENST00000414029 ENST00000416475
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35F6

    Additional mRNA sequence: 

    AK000562.1 AK025889.1 AK075164.1 AK222929.1 AK296996.1 AK299598.1 AY358820.1 BC005887.2 
    BC016389.1 BC028081.1 BC035519.1 BX647807.1 BX648017.1 CR457243.1 

    7 DOTS entries:

    DT.100776981  DT.100776979  DT.91688975  DT.121020530  DT.87006882  DT.95162633  DT.95365836 

    24/235 AceView cDNA sequences (see all 235):

    BM719753 BC035519 AA605065 H28043 BX648017 BX108564 AI202608 AI685226 
    AW235145 AA743685 AI394337 BE677115 AI784079 AA609044 BM834703 CR595898 
    AI263576 BQ009148 BM721691 CK300659 AI452465 BC000881 BQ945655 BF982268 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC35F6 expression in normal human tissues (normalized intensities)      SLC35F6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC35F6 Expression
    About this image


    SLC35F6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Neural Tube (Nervous System)
             Prosencephalon

    See SLC35F6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC35F6

    SOURCE GeneReport for Unigene cluster: Hs.516034

    UniProtKB/Swiss-Prot: S35F6_HUMAN, Q8N357
    Tissue specificity: Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in
    prostate and thyroid. Weakly expressed in lung, heart, liver and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC35F6 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc35f65
    4930471M23Rik1
    RIKEN cDNA 4930471M23 gene1, 5 85.62(n)1
    87.06(a)1
      5 (16.74 cM)5
    749191  NM_175675.31  NP_783606.21 
     306479335 
    chicken
    (Gallus gallus)
    Aves C3H2orf181 chromosome 3 open reading frame, human C2orf18 78.99(n)
    80.98(a)
      431081  XM_428633.3  XP_428633.2 
    lizard
    (Anolis carolinensis)
    Reptilia C2ORF186
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343919.1(87639-104508)
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb4332 sbcb433 76.57(n)   368354  BI891942.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tango96
    Transport and Golgi organization 9
    33(a)
    1 ↔ 1
    3R(7798808-7800587)
    worm
    (Caenorhabditis elegans)
    Secernentea C29H12.21 Protein C29H12.2 56.41(n)
    55.38(a)
      174022  NM_062825.3  NP_495226.1 
    K. lactis yeast
    (Kluyveromyces lactis)
    Saccharomycetes KLLA0C04433g1 hypothetical protein 44.06(n)
    34.39(a)
      2892082  XM_452395.1  XP_452395.1 


    ENSEMBL Gene Tree for SLC35F6 (if available)
    TreeFam Gene Tree for SLC35F6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC35F6 gene
    1 SIMAP similar gene for SLC35F6 using alignment to 3 protein entries:     S35F6_HUMAN (see all proteins):
    C2orf18

    SLC35F6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/375 SNPs in SLC35F6 are shown (see all 375)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916586031,2
    --26985142(+) ACTGAA/GTTTTG 1 -- us2k10--------
    rs1831703191,2
    --26985532(+) AAAATC/TTGCAT 1 -- us2k10--------
    rs1498036011,2
    --26985559(+) TTACCA/GGCCGG 1 -- us2k10--------
    rs1870940331,2
    --26985641(+) GCCTGC/GCCAAC 1 -- us2k10--------
    rs792121631,2
    C--26985861(+) TAACAC/TAGATA 1 -- us2k10--------
    rs8282541,2
    C,F,A--26985879(+) TTCCCG/CTTTCC 1 -- us2k16Minor allele frequency- C:0.38NA WA 250
    rs130181031,2
    C,F--26985903(+) cccctC/Tctccc 1 -- us2k18Minor allele frequency- T:0.24NA CSA WA EA 368
    rs2021145791,2
    C--26985911(+) CCGGC-/TTTTGA 1 -- us2k10--------
    rs1837625821,2
    --26985922(+) GTTGTC/TCTACC 1 -- us2k10--------
    rs1456966381,2
    --26986000(+) GCGCCC/TCGACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC35F6 (26987142 - 27004099 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC35F6: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC35F6
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC35F6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for SLC35F6:    About MalaCards
    pancreatic ductal adenocarcinoma    thyroiditis    adenocarcinoma    pancreatitis
    prostatitis


    SLC35F6 for disorders           About GeneDecksing


    Export disorders for SLC35F6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC35F6 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SLC35F6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis. (PubMed id 19154410)1, 2, 3 Kashiwaya K....Nakagawa H. (2009)
    2. The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP- N-acetylglucosamine. (PubMed id 15911612)1, 3 Ashikov A.... Bakker H. (2005)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54978 HGNC: 26055 AceView: CENPAandC2orf18 Ensembl:ENSG00000213699 euGenes: HUgn54978
    ECgene: SLC35F6 H-InvDB: SLC35F6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC35F6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC35F6 gene:
    Search GeneIP for patents involving SLC35F6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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