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Aliases for SLC35F5 Gene

Aliases for SLC35F5 Gene

  • Solute Carrier Family 35 Member F5 2 3 5
  • Hepatitis C Virus NS5A-Transactivated Protein 3 4
  • Solute Carrier Family 35, Member F5 2
  • HCV NS5A-Transactivated Protein 3 4
  • NS5ATP3 4

External Ids for SLC35F5 Gene

Previous GeneCards Identifiers for SLC35F5 Gene

  • GC02M114567
  • GC02M114188
  • GC02M114462
  • GC02M106790

Summaries for SLC35F5 Gene

GeneCards Summary for SLC35F5 Gene

SLC35F5 (Solute Carrier Family 35 Member F5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SLC35F5 Gene

  • Putative solute transporter.

Additional gene information for SLC35F5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35F5 Gene

Genomics for SLC35F5 Gene

Regulatory Elements for SLC35F5 Gene

Enhancers for SLC35F5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H113817 1.1 Ensembl ENCODE 25.5 -62.0 -61953 2 ELF3 FOXA2 RAD21 RARA ZSCAN5C FOS NR2F2 TGIF2 KLF16 SMARCA4 SLC35F5 ENSG00000228857 ACTR3 RPL23AP7 LOC105373570 GC02M113811
GH02H113885 1.8 FANTOM5 ENCODE dbSUPER 14.2 -134.0 -134016 9.8 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 GLIS1 ACTR3 SLC35F5 ENSG00000227359 WASH2P ENSG00000244063 LINC01191 RPL23AP7 DDX11L2 CBWD2 LOC101060091
GH02H113876 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.6 -120.8 -120783 3.3 PKNOX1 FOXA2 ZFP64 ARID4B FEZF1 SP5 MXD4 MIER2 PPARG KAT8 ENSG00000228857 ENSG00000244063 ACTR3 SLC35F5 RPL23AP7 ENSG00000270019
GH02H113905 0.5 dbSUPER 15.5 -149.7 -149709 2.2 ZNF217 ZBTB33 THRB SPI1 RXRB ENSG00000244063 SLC35F5 RPL23AP7 LINC01191 ENSG00000279957 GC02P113964
GH02H113702 0.5 ENCODE 14.6 +53.3 53327 1.5 PRDM6 POLR2A ZBTB33 DDX11L2 SLC35F5 RNU6-744P ACTR3 ENSG00000227359
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35F5 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35F5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000122127 623 2801 HDGF FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Locations for SLC35F5 Gene

Genomic Locations for SLC35F5 Gene
chr2:113,705,011-113,756,823
(GRCh38/hg38)
Size:
51,813 bases
Orientation:
Minus strand
chr2:114,462,588-114,514,400
(GRCh37/hg19)

Genomic View for SLC35F5 Gene

Genes around SLC35F5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35F5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35F5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35F5 Gene

Proteins for SLC35F5 Gene

  • Protein details for SLC35F5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV83-S35F5_HUMAN
    Recommended name:
    Solute carrier family 35 member F5
    Protein Accession:
    Q8WV83
    Secondary Accessions:
    • Q9H6P8
    • Q9H7D8

    Protein attributes for SLC35F5 Gene

    Size:
    523 amino acids
    Molecular mass:
    58887 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14954.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35F5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35F5 Gene

Post-translational modifications for SLC35F5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC35F5 Gene

Domains & Families for SLC35F5 Gene

Gene Families for SLC35F5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35F5 Gene

Suggested Antigen Peptide Sequences for SLC35F5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WV83

UniProtKB/Swiss-Prot:

S35F5_HUMAN :
  • Belongs to the SLC35F solute transporter family.
Family:
  • Belongs to the SLC35F solute transporter family.
genes like me logo Genes that share domains with SLC35F5: view

Function for SLC35F5 Gene

Molecular function for SLC35F5 Gene

UniProtKB/Swiss-Prot Function:
Putative solute transporter.
genes like me logo Genes that share phenotypes with SLC35F5: view

miRNA for SLC35F5 Gene

miRTarBase miRNAs that target SLC35F5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35F5 Gene

Localization for SLC35F5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35F5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35F5 gene
Compartment Confidence
plasma membrane 4
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC35F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35F5: view

Pathways & Interactions for SLC35F5 Gene

SuperPathways for SLC35F5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IBA --
genes like me logo Genes that share ontologies with SLC35F5: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35F5 Gene

Drugs & Compounds for SLC35F5 Gene

No Compound Related Data Available

Transcripts for SLC35F5 Gene

Unigene Clusters for SLC35F5 Gene

Solute carrier family 35, member F5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35F5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b
SP1: -
SP2: - -
SP3:
SP4:
SP5: -
SP6: -
SP7: -

Relevant External Links for SLC35F5 Gene

GeneLoc Exon Structure for
SLC35F5
ECgene alternative splicing isoforms for
SLC35F5

Expression for SLC35F5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35F5 Gene

Protein differential expression in normal tissues from HIPED for SLC35F5 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC35F5 Gene



Protein tissue co-expression partners for SLC35F5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35F5 Gene:

SLC35F5

SOURCE GeneReport for Unigene cluster for SLC35F5 Gene:

Hs.632527

mRNA Expression by UniProt/SwissProt for SLC35F5 Gene:

Q8WV83-S35F5_HUMAN
Tissue specificity: Expressed in colorectal cancer cells.
genes like me logo Genes that share expression patterns with SLC35F5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35F5 Gene

Orthologs for SLC35F5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35F5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35F5 33 34
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia SLC35F5 33 34
  • 94.07 (n)
cow
(Bos Taurus)
Mammalia SLC35F5 33 34
  • 93.56 (n)
mouse
(Mus musculus)
Mammalia Slc35f5 33 16 34
  • 88.66 (n)
rat
(Rattus norvegicus)
Mammalia Slc35f5 33
  • 88.59 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC35F5 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35F5 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35F5 33 34
  • 84.38 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35F5 34
  • 88 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8195 33 34
  • 51.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006969 33
  • 50 (n)
worm
(Caenorhabditis elegans)
Secernentea B0041.5 33 34
  • 45.78 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YML018C 33
  • 48.7 (n)
-- 34
  • 34 (a)
OneToMany
THI74 34 36
  • 33 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01177g 33
  • 47.81 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G32140 33
  • 46.05 (n)
rice
(Oryza sativa)
Liliopsida Os04g0645600 33
  • 47.29 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC405.03c 33
  • 50.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13326 33
Species where no ortholog for SLC35F5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC35F5 Gene

ENSEMBL:
Gene Tree for SLC35F5 (if available)
TreeFam:
Gene Tree for SLC35F5 (if available)

Paralogs for SLC35F5 Gene

No data available for Paralogs for SLC35F5 Gene

Variants for SLC35F5 Gene

Sequence variations from dbSNP and Humsavar for SLC35F5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000150155 -- 113,727,166(+) CTCTC(-/TT)GCCAG intron-variant
rs1000194637 -- 113,703,321(+) ATATG(C/G)TAAAA utr-variant-3-prime
rs1000225897 -- 113,703,612(+) TCTTC(C/T)GGTTT utr-variant-3-prime
rs1000282417 -- 113,754,003(+) ACTTA(C/T)ATACT intron-variant
rs1000290699 -- 113,709,062(+) GAACA(A/C)CCTAA intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC35F5 Gene

Variant ID Type Subtype PubMed ID
nsv819660 CNV loss 19587683
nsv2883 CNV deletion 18451855
nsv2882 CNV insertion 18451855
nsv1001195 CNV gain 25217958
esv3592028 CNV gain 21293372
esv3592016 CNV gain 21293372

Variation tolerance for SLC35F5 Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35F5 Gene

Human Gene Mutation Database (HGMD)
SLC35F5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35F5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35F5 Gene

Disorders for SLC35F5 Gene

Relevant External Links for SLC35F5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35F5

No disorders were found for SLC35F5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35F5 Gene

Publications for SLC35F5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for SLC35F5 Gene

Sources for SLC35F5 Gene

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