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Aliases for SLC35F5 Gene

Aliases for SLC35F5 Gene

  • Solute Carrier Family 35 Member F5 2 3 5
  • Hepatitis C Virus NS5A-Transactivated Protein 3 4
  • Solute Carrier Family 35, Member F5 2
  • HCV NS5A-Transactivated Protein 3 4
  • NS5ATP3 4

External Ids for SLC35F5 Gene

Previous GeneCards Identifiers for SLC35F5 Gene

  • GC02M114567
  • GC02M114188
  • GC02M114462
  • GC02M106790

Summaries for SLC35F5 Gene

GeneCards Summary for SLC35F5 Gene

SLC35F5 (Solute Carrier Family 35 Member F5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SLC35F5 Gene

  • Putative solute transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35F5 Gene

Genomics for SLC35F5 Gene

Regulatory Elements for SLC35F5 Gene

Enhancers for SLC35F5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F113817 1.1 Ensembl ENCODE 25.5 -62.0 -61953 2.0 ELF3 SIN3A ZNF48 RAD21 RARA FOS ZNF263 NR2F2 TGIF2 KLF16 SLC35F5 ENSG00000228857 ACTR3 RPL23AP7 LOC105373570 GC02M113811
GH02F113885 1.5 FANTOM5 ENCODE 14.2 -134.0 -134016 9.8 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ACTR3 SLC35F5 ENSG00000227359 ENSG00000244063 LINC01191 RPL23AP7 DDX11L2 WASH2P CBWD2 LOC101060091
GH02F113754 1.1 ENCODE 11.1 +0.4 449 3.0 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ENSG00000227359 DDX11L2 RPL23AP7 CKAP2L SLC35F5 ENSG00000228857 MIR4782
GH02F113323 1.2 Ensembl ENCODE 9.9 +432.0 431993 2.5 PKNOX1 ZNF48 GLIS2 ZNF366 SCRT2 KLF7 ZNF263 SP3 ZEB2 ZNF264 LOC101927400 RPS20P11 PAX8 ENSG00000227359 PAX8-AS1 PSD4 RGPD8 SLC35F5 CBWD2 ACTR3
GH02F113907 0.7 Ensembl 15.5 -152.6 -152578 4.8 NR2F1 JUN THRB TBX21 ZNF316 GATA3 JUND CBX5 HMBOX1 FOS SLC35F5 ENSG00000244063 ACTR3 RPL23AP7 LINC01191 ENSG00000279957 GC02P113964
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35F5 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35F5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000597020 722 3400 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for SLC35F5 Gene

Chromosome:
2
Start:
113,705,011 bp from pter
End:
113,756,823 bp from pter
Size:
51,813 bases
Orientation:
Minus strand

Genomic View for SLC35F5 Gene

Genes around SLC35F5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35F5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35F5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35F5 Gene

Proteins for SLC35F5 Gene

  • Protein details for SLC35F5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV83-S35F5_HUMAN
    Recommended name:
    Solute carrier family 35 member F5
    Protein Accession:
    Q8WV83
    Secondary Accessions:
    • Q9H6P8
    • Q9H7D8

    Protein attributes for SLC35F5 Gene

    Size:
    523 amino acids
    Molecular mass:
    58887 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14954.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35F5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35F5 Gene

Post-translational modifications for SLC35F5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC35F5 Gene

Domains & Families for SLC35F5 Gene

Gene Families for SLC35F5 Gene

Protein Domains for SLC35F5 Gene

Suggested Antigen Peptide Sequences for SLC35F5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WV83

UniProtKB/Swiss-Prot:

S35F5_HUMAN :
  • Contains 1 EamA domain.
  • Belongs to the SLC35F solute transporter family.
Domain:
  • Contains 1 EamA domain.
Family:
  • Belongs to the SLC35F solute transporter family.
genes like me logo Genes that share domains with SLC35F5: view

Function for SLC35F5 Gene

Molecular function for SLC35F5 Gene

UniProtKB/Swiss-Prot Function:
Putative solute transporter.
genes like me logo Genes that share phenotypes with SLC35F5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35F5

miRNA for SLC35F5 Gene

miRTarBase miRNAs that target SLC35F5

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35F5 Gene

Localization for SLC35F5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35F5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35F5 gene
Compartment Confidence
plasma membrane 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC35F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35F5: view

Pathways & Interactions for SLC35F5 Gene

SuperPathways for SLC35F5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IBA --
genes like me logo Genes that share ontologies with SLC35F5: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35F5 Gene

Transcripts for SLC35F5 Gene

Unigene Clusters for SLC35F5 Gene

Solute carrier family 35, member F5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35F5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b
SP1: -
SP2: - -
SP3:
SP4:
SP5: -
SP6: -
SP7: -

Relevant External Links for SLC35F5 Gene

GeneLoc Exon Structure for
SLC35F5
ECgene alternative splicing isoforms for
SLC35F5

Expression for SLC35F5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC35F5 Gene

Protein differential expression in normal tissues from HIPED for SLC35F5 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC35F5 Gene



Protein tissue co-expression partners for SLC35F5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35F5 Gene:

SLC35F5

SOURCE GeneReport for Unigene cluster for SLC35F5 Gene:

Hs.632527

mRNA Expression by UniProt/SwissProt for SLC35F5 Gene:

Q8WV83-S35F5_HUMAN
Tissue specificity: Expressed in colorectal cancer cells.
genes like me logo Genes that share expression patterns with SLC35F5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC35F5 Gene

Orthologs for SLC35F5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35F5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35F5 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia SLC35F5 34 35
  • 94.07 (n)
cow
(Bos Taurus)
Mammalia SLC35F5 34 35
  • 93.56 (n)
mouse
(Mus musculus)
Mammalia Slc35f5 34 16 35
  • 88.66 (n)
rat
(Rattus norvegicus)
Mammalia Slc35f5 34
  • 88.59 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC35F5 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35F5 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35F5 34 35
  • 84.38 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35F5 35
  • 88 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8195 34 35
  • 51.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006969 34
  • 50 (n)
worm
(Caenorhabditis elegans)
Secernentea B0041.5 34 35
  • 45.78 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YML018C 34
  • 48.7 (n)
-- 35
  • 34 (a)
OneToMany
THI74 35 37
  • 33 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01177g 34
  • 47.81 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G32140 34
  • 46.05 (n)
rice
(Oryza sativa)
Liliopsida Os04g0645600 34
  • 47.29 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC405.03c 34
  • 50.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13326 34
Species where no ortholog for SLC35F5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC35F5 Gene

ENSEMBL:
Gene Tree for SLC35F5 (if available)
TreeFam:
Gene Tree for SLC35F5 (if available)

Paralogs for SLC35F5 Gene

No data available for Paralogs for SLC35F5 Gene

Variants for SLC35F5 Gene

Sequence variations from dbSNP and Humsavar for SLC35F5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10168234 -- 113,737,161(+) AGAAG(A/G)ACATC intron-variant
rs10172842 -- 113,735,644(+) CAGTT(A/G)TAATA intron-variant
rs10183693 -- 113,722,840(+) GAACA(A/G)AATCA intron-variant, upstream-variant-2KB
rs10197009 -- 113,715,950(+) AAAAA(A/T)Atata intron-variant
rs10199515 -- 113,735,738(+) ATACA(A/C)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35F5 Gene

Variant ID Type Subtype PubMed ID
esv3592016 CNV gain 21293372
esv3592028 CNV gain 21293372
nsv1001195 CNV gain 25217958
nsv2882 CNV insertion 18451855
nsv2883 CNV deletion 18451855
nsv819660 CNV loss 19587683

Variation tolerance for SLC35F5 Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35F5 Gene

Human Gene Mutation Database (HGMD)
SLC35F5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35F5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35F5 Gene

Disorders for SLC35F5 Gene

Relevant External Links for SLC35F5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35F5

No disorders were found for SLC35F5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35F5 Gene

Publications for SLC35F5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response. (PMID: 16477629) Matsuyama R. … Shimada H. (Int. J. Cancer 2006) 4 64

Products for SLC35F5 Gene

Sources for SLC35F5 Gene

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