SLC35F5 Gene
protein-coding GIFtS: 45
GCID: GC02M114462
|
|
solute carrier family 35, member F5
| |
Aliases
for SLC35F5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 35, Member F51 2 | | Hepatitis C Virus NS5A-Transactivated Protein 32 3 | | HCV NS5A-Transactivated Protein 32 3 | | FLJ220041 | | Solute Carrier Family 35 Member F52 | | NS5ATP33 |
Export aliases for SLC35F5 gene to outside databasesPrevious GC identifers: GC02M114567 GC02M114188 GC02M106790 |
Summaries
for SLC35F5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: S35F5_HUMAN, Q8WV83Function: Putative solute transporter (Potential)
|
Genomic Views
for SLC35F5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC35F5 gene promoter:
STAT1 FOXD3 STAT1beta STAT1alpha CREB POU2F1 Ik-2 FOXJ2 (long isoform) POU2F1a FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC35F5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35F5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q14.1 Ensembl cytogenetic band: 2q14.1 HGNC cytogenetic band: 2q14.1SLC35F5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M114462: view genomic region
(about GC identifiers)
Start:
|
114,462,588 bp from pter |
End:
|
114,514,400 bp from pter |
Size:
|
51,813 bases |
Orientation:
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minus strand |
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Proteins
for SLC35F5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S35F5_HUMAN, Q8WV83 (See
protein sequence)Recommended Name: Solute carrier family 35 member F5 Size: 523 amino acids; 58887 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAB14954.1; Type=Erroneous initiation;
Secondary accessions: Q9H6P8 Q9H7D8Alternative splicing: 2 isoforms: Q8WV83-1 Q8WV83-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC35F5: NX_Q8WV83
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WV83
SLC35F5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079457.2
ENSEMBL proteins: ENSP00000245680 ENSP00000386754 ENSP00000406253 ENSP00000396456 ENSP00000386991
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SLC35F5 for ontologies About GeneDecksing
SLC35F5 Antibody Products:
Assay Products for SLC35F5: |
Protein
Domains /
Families
for SLC35F5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC35F5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WV83ProtoNet protein and cluster: Q8WV83 1 Blocks protein family: IPB000620 Protein of unknown function DUF6
UniProtKB/Swiss-Prot: S35F5_HUMAN, Q8WV83Similarity: Belongs to the SLC35F solute transporter familySimilarity: Contains 1 EamA domain |
Function
for SLC35F5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S35F5_HUMAN, Q8WV83Function: Putative solute transporter (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35F5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35F5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC35F5 (NM_025181) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC35F5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35F5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35F5 |
Animal Models:
Mouse knock-out Slc35f5tm1Lex for SLC35F5
1 MGI phenotypic allele  for Slc35f5 (no phenotypes)
SLC35F5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SLC35F5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35F5
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/19 Interacting proteins for SLC35F5 (Q8WV833 ENSP000002456804) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- |
SLC35F5 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC35F5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC35F5
Search CenterWatch for drugs/clinical trials and news about SLC35F5 / S35F5
|
Transcripts
for SLC35F5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC35F5 gene: NM_025181.2 Unigene Cluster for SLC35F5: Solute carrier family 35, member F5 Hs.632527 [show with all ESTs]Unigene Representative Sequence: BC05009612 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000469702 ENST00000245680(uc002tku.1) ENST00000409106(uc002tkt.3)
ENST00000420066 ENST00000459683 ENST00000470204 ENST00000469314 ENST00000447673
ENST00000485214 ENST00000409342(uc002tkv.3) ENST00000498768 ENST00000460863
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35F5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35F5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC35F5 (NM_025181) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC35F5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35F5 |
Additional cDNA sequence: AF529364.1 AK025657.1 AK315719.1 AY358620.1 BC018537.1 BC050096.1 14 DOTS entries: DT.115648 DT.109902 DT.100795164 DT.100795156 DT.100795161 DT.100795157 DT.308384 DT.100658012 DT.97784072 DT.100795159 DT.120997123 DT.120997174 DT.91749406 DT.95342957 24/160 AceView cDNA sequences (see all 160): AI911442 BQ004632 AF529364 AL711193 CR615423 AA385337 BX363850 BG261384 AA810277 BQ014794 CA489269 AW514850 BX457556 AU279944 AA465455 AA298173 CB162573 CA943104 BM470126 BG623237 AY358620 BE963052 AA913052 AI038495
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SLC35F5 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for SLC35F5
|
Expression
for SLC35F5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC35F5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAAATTTTT
About this image
See SLC35F5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC35F5
SOURCE GeneReport for Unigene cluster: Hs.632527
UniProtKB/Swiss-Prot: S35F5_HUMAN, Q8WV83Tissue specificity: Expressed in colorectal cancer cells
SABiosciences Custom PCR Arrays for SLC35F5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC35F5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC35F5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35F5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35F5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35F5 |
Orthologs
for SLC35F5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC35F5 gene from 10/28 species (see all 28) About this table
ENSEMBL Gene Tree for SLC35F5 (if available)
TreeFam Gene Tree for SLC35F5 (if available) |
Paralogs
for SLC35F5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SLC35F5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC35F5 (114462588 - 114514400 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLC35F5
1 CNV: 35709
1 Indel: 58908 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC35F5 |
|
Disorders
/ Diseases
for SLC35F5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC35F5 for disorders About GeneDecksing
1  disease for SLC35F5: About MalaCardscolorectal cancer
Export disorders for SLC35F5 gene to outside databases
|
Publications
for SLC35F5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC35F5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC35F5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response. (PubMed id 16477629)2 Matsuyama R....Shimada H. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for SLC35F5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC35F5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC35F5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC35F5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC35F5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC35F5 gene:
Search GeneIP for patents involving SLC35F5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC35F5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC35F5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC35F5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC35F5 | | | OriGene Protein Over-expression Lysate for SLC35F5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC35F5 | | OriGene 3'-UTR Clone for SLC35F5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35F5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35F5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC35F5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC35F5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35F5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC35F5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35F5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35F5 |
| |
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| |  |  |  |  | | | | |
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 | | | SLC35F5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35F5 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35F5 |
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