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Aliases for SLC35F4 Gene

Aliases for SLC35F4 Gene

  • Solute Carrier Family 35 Member F4 2 3 5
  • C14orf36 3 4
  • Chromosome 14 Open Reading Frame 36 2
  • Solute Carrier Family 35, Member F4 2
  • C14_5373 3

External Ids for SLC35F4 Gene

Previous HGNC Symbols for SLC35F4 Gene

  • C14orf36

Previous GeneCards Identifiers for SLC35F4 Gene

  • GC14M056021
  • GC14M056022
  • GC14M057100
  • GC14M058030
  • GC14M038196

Summaries for SLC35F4 Gene

GeneCards Summary for SLC35F4 Gene

SLC35F4 (Solute Carrier Family 35 Member F4) is a Protein Coding gene. An important paralog of this gene is SLC35F3.

UniProtKB/Swiss-Prot for SLC35F4 Gene

  • Putative solute transporter.

Additional gene information for SLC35F4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35F4 Gene

Genomics for SLC35F4 Gene

Regulatory Elements for SLC35F4 Gene

Enhancers for SLC35F4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H057833 1.1 ENCODE dbSUPER 28.9 +148.7 148689 1.2 ZBTB21 JUN INSM2 HIC1 GLIS2 ZBTB48 ZNF366 POLR2A FOS ZBTB20 SLC35F4 RN7SKP99 GC14M057656
GH14H058426 1.4 ENCODE dbSUPER 11.3 -445.7 -445671 3.6 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000259969 TIMM9 KIAA0586 PSMA3-AS1 ENSG00000258682 SLC35F4 HMGB1P14 RPL31P4 RPL9P5 GC14P058442
GH14H057822 0.4 dbSUPER 36.9 +158.8 158761 2.3 GFI1B SLC35F4 RN7SKP99 GC14M057656
GH14H058104 0.8 ENCODE 11.4 -122.7 -122684 0.2 FOXA2 NFIB ZBTB21 JUN FEZF1 SALL2 CTBP1 GATA3 ZNF366 ATF7 TOMM20L ENSG00000259969 DACT1 ENSG00000258682 SLC35F4 ARID4A KIAA0586 RPL31P4 PSMA3-AS1 LOC440181
GH14H057845 0.6 ENCODE dbSUPER 14.3 +135.3 135343 3.6 ATF2 SLC35F4 RN7SKP99 GC14M057931
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35F4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC35F4 Gene

Genomic Locations for SLC35F4 Gene
chr14:57,563,922-57,982,274
(GRCh38/hg38)
Size:
418,353 bases
Orientation:
Minus strand
chr14:58,030,640-58,448,912
(GRCh37/hg19)

Genomic View for SLC35F4 Gene

Genes around SLC35F4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35F4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35F4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35F4 Gene

Proteins for SLC35F4 Gene

  • Protein details for SLC35F4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4IF30-S35F4_HUMAN
    Recommended name:
    Solute carrier family 35 member F4
    Protein Accession:
    A4IF30
    Secondary Accessions:
    • A6NDQ3

    Protein attributes for SLC35F4 Gene

    Size:
    521 amino acids
    Molecular mass:
    57809 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35F4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35F4 Gene

Post-translational modifications for SLC35F4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC35F4 Gene

Domains & Families for SLC35F4 Gene

Gene Families for SLC35F4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35F4 Gene

Suggested Antigen Peptide Sequences for SLC35F4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4IF30

UniProtKB/Swiss-Prot:

S35F4_HUMAN :
  • Belongs to the SLC35F solute transporter family.
Family:
  • Belongs to the SLC35F solute transporter family.
genes like me logo Genes that share domains with SLC35F4: view

Function for SLC35F4 Gene

Molecular function for SLC35F4 Gene

UniProtKB/Swiss-Prot Function:
Putative solute transporter.

Phenotypes From GWAS Catalog for SLC35F4 Gene

Phenotypes for SLC35F4 Gene

GenomeRNAi human phenotypes for SLC35F4:
genes like me logo Genes that share phenotypes with SLC35F4: view

miRNA for SLC35F4 Gene

miRTarBase miRNAs that target SLC35F4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35F4 Gene

Localization for SLC35F4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35F4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35F4 gene
Compartment Confidence
plasma membrane 3
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC35F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35F4: view

Pathways & Interactions for SLC35F4 Gene

SuperPathways for SLC35F4 Gene

No Data Available

Interacting Proteins for SLC35F4 Gene

Selected Interacting proteins: A4IF30-S35F4_HUMAN for SLC35F4 Gene via IID

Symbol External ID(s) Details
SLC35D2

Gene Ontology (GO) - Biological Process for SLC35F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SLC35F4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35F4 Gene

Drugs & Compounds for SLC35F4 Gene

No Compound Related Data Available

Transcripts for SLC35F4 Gene

mRNA/cDNA for SLC35F4 Gene

Unigene Clusters for SLC35F4 Gene

Solute carrier family 35, member F4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35F4 Gene

No ASD Table

Relevant External Links for SLC35F4 Gene

GeneLoc Exon Structure for
SLC35F4
ECgene alternative splicing isoforms for
SLC35F4

Expression for SLC35F4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35F4 Gene

mRNA differential expression in normal tissues according to GTEx for SLC35F4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x14.5) and Brain - Cerebellum (x14.3).

NURSA nuclear receptor signaling pathways regulating expression of SLC35F4 Gene:

SLC35F4

SOURCE GeneReport for Unigene cluster for SLC35F4 Gene:

Hs.28280
genes like me logo Genes that share expression patterns with SLC35F4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35F4 Gene

Orthologs for SLC35F4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35F4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35F4 33 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia SLC35F4 33 34
  • 93.66 (n)
cow
(Bos Taurus)
Mammalia SLC35F4 33 34
  • 93.25 (n)
mouse
(Mus musculus)
Mammalia Slc35f4 33 16 34
  • 89.88 (n)
rat
(Rattus norvegicus)
Mammalia Slc35f4 33
  • 88.98 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC35F4 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35F4 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35F4 33 34
  • 81.34 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35F4 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35f4 33
  • 75.83 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100535737 33
  • 69.97 (n)
SLC35F4 34
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42322 34
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y73B6BL.31 34
  • 28 (a)
OneToMany
Species where no ortholog for SLC35F4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35F4 Gene

ENSEMBL:
Gene Tree for SLC35F4 (if available)
TreeFam:
Gene Tree for SLC35F4 (if available)

Paralogs for SLC35F4 Gene

Paralogs for SLC35F4 Gene

(1) SIMAP similar genes for SLC35F4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC35F4: view

Variants for SLC35F4 Gene

Sequence variations from dbSNP and Humsavar for SLC35F4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000003450 -- 57,786,900(+) TGGAC(C/T)CAAAC intron-variant
rs1000009218 -- 57,672,954(+) ATTTC(A/C)CTGTG intron-variant
rs1000017643 -- 57,655,835(+) ACTCC(C/T)AATAA intron-variant
rs1000022986 -- 57,825,032(+) TGAAC(C/G)AGAAT intron-variant
rs1000029500 -- 57,633,843(+) GTTGT(G/T)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35F4 Gene

Variant ID Type Subtype PubMed ID
nsv974340 CNV duplication 23825009
nsv528158 CNV loss 19592680
nsv526016 CNV loss 19592680
nsv517592 CNV loss 19592680
nsv515859 CNV loss 19592680
nsv477199 CNV novel sequence insertion 20440878
nsv436182 CNV deletion 17901297
nsv1289 CNV deletion 18451855
nsv1138304 CNV deletion 24896259
nsv1046422 CNV gain 25217958
nsv1043109 CNV loss 25217958
nsv1040402 CNV loss 25217958
esv3634614 CNV loss 21293372
esv3634613 CNV loss 21293372
esv3634612 CNV loss 21293372
esv3634611 CNV loss 21293372
esv3551599 CNV deletion 23714750
esv2760358 CNV loss 21179565
esv2748729 CNV deletion 23290073
esv2748728 CNV deletion 23290073
esv2669570 CNV deletion 23128226
esv2662506 CNV deletion 23128226
esv2656934 CNV deletion 23128226
esv25360 CNV loss 19812545
esv24720 CNV gain 19812545

Variation tolerance for SLC35F4 Gene

Gene Damage Index Score: 1.47; 28.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35F4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35F4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35F4 Gene

Disorders for SLC35F4 Gene

Relevant External Links for SLC35F4

Genetic Association Database (GAD)
SLC35F4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35F4

No disorders were found for SLC35F4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35F4 Gene

Publications for SLC35F4 Gene

  1. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PMID: 21254220) Jiang Y … Zhang H (Genetic epidemiology 2011) 3 45 60
  2. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PMID: 17554300) Wellcome Trust Case Control Consortium (Nature 2007) 3 45 60
  3. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang KS … Aragam N (Schizophrenia research 2010) 3 60
  4. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J … NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) (PLoS genetics 2009) 45 60
  5. Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. (PMID: 18937294) Lasky-Su J … Faraone SV (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 45 60

Products for SLC35F4 Gene

Sources for SLC35F4 Gene

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