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Aliases for SLC35F4 Gene

Aliases for SLC35F4 Gene

  • Solute Carrier Family 35 Member F4 2 3 5
  • Solute Carrier Family 35, Member F4 2 3
  • C14orf36 3 4
  • Chromosome 14 Open Reading Frame 36 2
  • C14_5373 3

External Ids for SLC35F4 Gene

Previous HGNC Symbols for SLC35F4 Gene

  • C14orf36

Previous GeneCards Identifiers for SLC35F4 Gene

  • GC14M056021
  • GC14M056022
  • GC14M057100
  • GC14M058030
  • GC14M038196

Summaries for SLC35F4 Gene

GeneCards Summary for SLC35F4 Gene

SLC35F4 (Solute Carrier Family 35 Member F4) is a Protein Coding gene. An important paralog of this gene is SLC35F3.

UniProtKB/Swiss-Prot for SLC35F4 Gene

  • Putative solute transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35F4 Gene

Genomics for SLC35F4 Gene

Regulatory Elements for SLC35F4 Gene

Enhancers for SLC35F4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC35F4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35F4 Gene

Chromosome:
14
Start:
57,563,922 bp from pter
End:
57,982,274 bp from pter
Size:
418,353 bases
Orientation:
Minus strand

Genomic View for SLC35F4 Gene

Genes around SLC35F4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35F4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35F4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35F4 Gene

Proteins for SLC35F4 Gene

  • Protein details for SLC35F4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4IF30-S35F4_HUMAN
    Recommended name:
    Solute carrier family 35 member F4
    Protein Accession:
    A4IF30
    Secondary Accessions:
    • A6NDQ3

    Protein attributes for SLC35F4 Gene

    Size:
    521 amino acids
    Molecular mass:
    57809 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35F4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35F4 Gene

Proteomics data for SLC35F4 Gene at MOPED

Post-translational modifications for SLC35F4 Gene

No Post-translational modifications

Other Protein References for SLC35F4 Gene

No data available for DME Specific Peptides for SLC35F4 Gene

Domains & Families for SLC35F4 Gene

Gene Families for SLC35F4 Gene

Protein Domains for SLC35F4 Gene

Suggested Antigen Peptide Sequences for SLC35F4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4IF30

UniProtKB/Swiss-Prot:

S35F4_HUMAN :
  • Contains 1 EamA domain.
  • Belongs to the SLC35F solute transporter family.
Domain:
  • Contains 1 EamA domain.
Family:
  • Belongs to the SLC35F solute transporter family.
genes like me logo Genes that share domains with SLC35F4: view

Function for SLC35F4 Gene

Molecular function for SLC35F4 Gene

UniProtKB/Swiss-Prot Function:
Putative solute transporter.

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35F4

miRNA for SLC35F4 Gene

miRTarBase miRNAs that target SLC35F4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35F4 Gene

Localization for SLC35F4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35F4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35F4 Gene COMPARTMENTS Subcellular localization image for SLC35F4 gene
Compartment Confidence
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC35F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35F4: view

Pathways & Interactions for SLC35F4 Gene

SuperPathways for SLC35F4 Gene

No Data Available

Interacting Proteins for SLC35F4 Gene

Gene Ontology (GO) - Biological Process for SLC35F4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC35F4 Gene

Drugs & Compounds for SLC35F4 Gene

No Compound Related Data Available

Transcripts for SLC35F4 Gene

mRNA/cDNA for SLC35F4 Gene

Unigene Clusters for SLC35F4 Gene

Solute carrier family 35, member F4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35F4 Gene

No ASD Table

Relevant External Links for SLC35F4 Gene

GeneLoc Exon Structure for
SLC35F4
ECgene alternative splicing isoforms for
SLC35F4

Expression for SLC35F4 Gene

mRNA expression in normal human tissues for SLC35F4 Gene

mRNA differential expression in normal tissues according to GTEx for SLC35F4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x14.5) and Brain - Cerebellum (x14.3).

SOURCE GeneReport for Unigene cluster for SLC35F4 Gene Hs.28280

genes like me logo Genes that share expression patterns with SLC35F4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC35F4 Gene

Orthologs for SLC35F4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35F4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC35F4 35
  • 93.25 (n)
  • 96.69 (a)
SLC35F4 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC35F4 35
  • 93.66 (n)
  • 97.11 (a)
SLC35F4 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35f4 35
  • 89.88 (n)
  • 95.45 (a)
Slc35f4 16
Slc35f4 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC35F4 35
  • 99.66 (n)
  • 99.79 (a)
SLC35F4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35f4 35
  • 88.98 (n)
  • 95.25 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC35F4 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35F4 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35F4 35
  • 81.34 (n)
  • 86.36 (a)
SLC35F4 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35F4 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35f4 35
  • 75.83 (n)
  • 85.31 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100535737 35
  • 69.97 (n)
  • 77 (a)
SLC35F4 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42322 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y73B6BL.31 36
  • 28 (a)
OneToMany
Species with no ortholog for SLC35F4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35F4 Gene

ENSEMBL:
Gene Tree for SLC35F4 (if available)
TreeFam:
Gene Tree for SLC35F4 (if available)

Paralogs for SLC35F4 Gene

Paralogs for SLC35F4 Gene

(1) SIMAP similar genes for SLC35F4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC35F4: view

Variants for SLC35F4 Gene

Sequence variations from dbSNP and Humsavar for SLC35F4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs115229 -- 57,876,202(+) GCAGT(A/T)AGTTT intron-variant
rs171139 -- 57,615,000(+) TTCTC(A/C)TCCAT intron-variant
rs173215 -- 57,584,213(+) TTCTC(C/T)TGTAG intron-variant
rs180872 -- 57,593,868(+) TGTGA(C/T)AATGG intron-variant
rs180873 -- 57,585,061(-) ACTGG(A/T)TTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35F4 Gene

Variant ID Type Subtype PubMed ID
nsv1289 CNV Loss 18451855
nsv515859 CNV Loss 19592680
nsv526016 CNV Loss 19592680
nsv528158 CNV Loss 19592680
nsv436182 CNV Deletion 17901297
esv25360 CNV Loss 19812545
esv2656934 CNV Deletion 23128226
nsv517592 CNV Loss 19592680
esv24720 CNV Gain 19812545
esv2662506 CNV Deletion 23128226
esv2748728 CNV Deletion 23290073
esv2748729 CNV Deletion 23290073
esv2669570 CNV Deletion 23128226

Variation tolerance for SLC35F4 Gene

Gene Damage Index Score: 1.47; 28.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC35F4 Gene

Disorders for SLC35F4 Gene

Relevant External Links for SLC35F4

Genetic Association Database (GAD)
SLC35F4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35F4

No disorders were found for SLC35F4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35F4 Gene

Publications for SLC35F4 Gene

  1. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PMID: 21254220) Jiang Y. … Zhang H. (Genet. Epidemiol. 2011) 3 48 67
  2. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 3
  3. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PMID: 17554300) (Nature 2007) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC35F4 Gene

Sources for SLC35F4 Gene

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